T Arai

Summary

Affiliation: Nippon Veterinary and Animal Science University
Country: Japan

Publications

  1. ncbi request reprint Increased serum and urinary neopterin in nephrotic syndrome indicate cell-mediated immune dysfunction
    K Oda
    Department of Internal Medicine, Teikyo University School of Medicine, 11 1, Kaga, 2 chome, Itabashi ku, Tokyo, 173 8605, Japan
    Am J Kidney Dis 34:611-7. 1999
  2. ncbi request reprint Decrease in malate dehydrogenase activities in peripheral leucocytes of type 1 diabetic dogs
    T Arai
    Department of Veterinary Science, Nippon Veterinary and Animal Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 74:183-5. 2003
  3. ncbi request reprint Activities of enzymes in the malate-aspartate shuttle and the isoenzyme pattern of lactate dehydrogenase in plasma and peripheral leukocytes of lactating Holstein cows and riding horses
    T Arai
    Divisions of Veterinary Biochemistry, Department of Veterinary Science, Nippon Veterinary and Animal Science University, Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 75:15-9. 2003
  4. ncbi request reprint Malate dehydrogenase activities are lower in some types of peripheral leucocytes of dogs and cats with type 1 diabetes mellitus
    E Magori
    Division of Veterinary Biochemistry, Department of Veterinary Science, Nippon Veterinary and Animal Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 78:39-44. 2005
  5. doi request reprint Time-action profiles of insulin detemir in normal and diabetic dogs
    T Sako
    Department of Veterinary Nursing and Technology, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 90:396-403. 2011
  6. ncbi request reprint Changes in activities of enzymes related to energy metabolism in peripheral leukocytes of diabetic dogs with glycemic control by intensive insulin treatment
    T Arai
    Division of Veterinary Biochemistry, Department of Veterinary Science, Nippon Veterinary and Animal Science University, Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 73:183-6. 2002
  7. ncbi request reprint Changes in peripheral leukocytes enzymes activity and plasma metabolite concentrations in growing Holstein calves
    T Arai
    Department of Veterinary Science, Nippon Veterinary and Animal Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 81:19-23. 2006
  8. ncbi request reprint Changes in activities of enzymes related to energy metabolism in testicular tissues of dogs with seminoma
    T Arai
    Department of Veterinary Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo, Japan
    Vet Res Commun 26:347-52. 2002
  9. ncbi request reprint Activities of enzymes in the malate-aspartate shuttle in the peripheral leukocytes of dogs and cats
    T Washizu
    Department of Veterinary Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo, Japan
    Vet Res Commun 25:623-9. 2001
  10. doi request reprint Hypertriglyceridemia with increased plasma insulin concentrations in cats
    Y Hatano
    School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 88:458-60. 2010

Collaborators

Detail Information

Publications67

  1. ncbi request reprint Increased serum and urinary neopterin in nephrotic syndrome indicate cell-mediated immune dysfunction
    K Oda
    Department of Internal Medicine, Teikyo University School of Medicine, 11 1, Kaga, 2 chome, Itabashi ku, Tokyo, 173 8605, Japan
    Am J Kidney Dis 34:611-7. 1999
    ..Increased serum NP concentrations and urinary NP/Cr ratios may reflect disordered cell-mediated immunity in the nephrotic syndrome, irrespective of glomerular histology or interstitial cell infiltration...
  2. ncbi request reprint Decrease in malate dehydrogenase activities in peripheral leucocytes of type 1 diabetic dogs
    T Arai
    Department of Veterinary Science, Nippon Veterinary and Animal Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 74:183-5. 2003
    ..The decrease of the M/L ratio appeared to reflect depression of energy metabolism in leucocytes of the diabetic dogs. The M/L ratio may be a useful parameter to evaluate metabolic conditions in diabetic dogs...
  3. ncbi request reprint Activities of enzymes in the malate-aspartate shuttle and the isoenzyme pattern of lactate dehydrogenase in plasma and peripheral leukocytes of lactating Holstein cows and riding horses
    T Arai
    Divisions of Veterinary Biochemistry, Department of Veterinary Science, Nippon Veterinary and Animal Science University, Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 75:15-9. 2003
    ..There were significant differences in activities of malate-aspartate shuttle enzymes, ML ratio and LDH isoenzyme patterns in the cytosolic fractions of leukocytes between the lactating cows and the riding horses...
  4. ncbi request reprint Malate dehydrogenase activities are lower in some types of peripheral leucocytes of dogs and cats with type 1 diabetes mellitus
    E Magori
    Division of Veterinary Biochemistry, Department of Veterinary Science, Nippon Veterinary and Animal Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 78:39-44. 2005
    ..The smaller M / L ratio appeared to reflect depression of energy metabolism in the diabetic animals. Intrinsically lower and further decreased MDH activities may be factors that induce insulin resistance observed in diabetic cats...
  5. doi request reprint Time-action profiles of insulin detemir in normal and diabetic dogs
    T Sako
    Department of Veterinary Nursing and Technology, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 90:396-403. 2011
    ..However, using insulin detemir also carries a higher risk of inducing hypoglycemia as compared to either NPH insulin or insulin glargine...
  6. ncbi request reprint Changes in activities of enzymes related to energy metabolism in peripheral leukocytes of diabetic dogs with glycemic control by intensive insulin treatment
    T Arai
    Division of Veterinary Biochemistry, Department of Veterinary Science, Nippon Veterinary and Animal Science University, Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 73:183-6. 2002
    ....
  7. ncbi request reprint Changes in peripheral leukocytes enzymes activity and plasma metabolite concentrations in growing Holstein calves
    T Arai
    Department of Veterinary Science, Nippon Veterinary and Animal Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 81:19-23. 2006
    ..Some peripheral leukocyte enzymes such as LDH and HK may be good indicators to evaluate changes in energy metabolism of growing calves...
  8. ncbi request reprint Changes in activities of enzymes related to energy metabolism in testicular tissues of dogs with seminoma
    T Arai
    Department of Veterinary Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo, Japan
    Vet Res Commun 26:347-52. 2002
    ..These enzymatic activities may be useful indicators with which to evaluate changes in the metabolic conditions in testicular tissues of dogs with seminoma...
  9. ncbi request reprint Activities of enzymes in the malate-aspartate shuttle in the peripheral leukocytes of dogs and cats
    T Washizu
    Department of Veterinary Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo, Japan
    Vet Res Commun 25:623-9. 2001
    ..High activities of MDH in canine leukocytes were confirmed by RT-PCR analysis on the total RNA extracted from leukocytes. It was concluded that there were significant differences between dogs and cats in the NADH shuttle system...
  10. doi request reprint Hypertriglyceridemia with increased plasma insulin concentrations in cats
    Y Hatano
    School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 88:458-60. 2010
    ..Increased TG, insulin, LDH and ALT and decreased adiponectin values in plasma seemed to be key factors for diagnosis of lipid metabolism abnormality at early stage in cats...
  11. ncbi request reprint Comparison of plasma metabolite concentrations and lactate dehydrogenase activity in dogs, cats, horses, cattle and sheep
    T Sako
    Department of Veterinary Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Vet Res Commun 31:413-7. 2007
  12. ncbi request reprint Comparison of plasma metabolite concentrations and peripheral leukocyte enzyme activities in sheep fed on different diets in New Zealand and Japan
    T Arai
    Department of Veterinary Science, Nippon Veterinary and Life Science University, Musashino, Tokyo
    Vet Res Commun 31:681-4. 2007
  13. ncbi request reprint Comparison of activities of enzymes related to energy metabolism in peripheral leukocytes and livers between Holstein dairy cows and ICR mice
    A Tanaka
    Department of Veterinary Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180 8602, Japan
    Vet Res Commun 30:29-38. 2006
    ..The LDH isoenzyme patterns were very similar between leukocytes and liver in each animal species. Some enzymes in leukocytes may reflect those enzymes activities in liver and be a useful indicator for energy metabolism in animals...
  14. ncbi request reprint Changes in activities of enzymes related to malate-aspartate shuttle in leukocytes from dogs given a herb supplement
    T Arai
    Division of Veterinary Biochemistry, Nippon Veterinary and Animal Science University, Tokyo, Japan
    J Vet Med Sci 63:695-7. 2001
    ..It is suggested that Echevaria glauca herb supplementation might activate NADH shuttle systems and mitochondrial energy metabolism in dogs...
  15. ncbi request reprint Enzyme activities in some types of peripheral leukocytes of thoroughbred race horses before and after the races
    M Hosoya
    Division of Veterinary Biochemistry, Department of Veterinary Science, Nippon Veterinary and Animal Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 77:101-4. 2004
    ..The cytosolic ratio of MDH/LDH activity (ML ratio) in leukocytes decreased significantly after racing, and the ratio may be a useful indicator to evaluate energy metabolism in race horses...
  16. doi request reprint Comparison of three commercially available prescription diet regimens on short-term post-prandial serum glucose and insulin concentrations in healthy cats
    A Mori
    Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1 7 1 Kyonancho, Musashino, Tokyo, 180 8602, Japan
    Vet Res Commun 33:669-80. 2009
    ..As such, having a better understanding for each dietary component, may lead us to better understand how we can synergize certain dietary components to aid in DM management...
  17. doi request reprint Comparison of insulin signaling gene expression in insulin sensitive tissues between cats and dogs
    A Mori
    Department of Veterinary Science, Nippon Veterinary and Life Science University, 1 7 1 Kyonancho, Musashino, Tokyo, 180 8602, Japan
    Vet Res Commun 33:211-26. 2009
    ..Therefore, a combination of genetic and environmental factors appears to make felines more prone to suffer from insulin resistance and type 2 DM than canines...
  18. doi request reprint Hepatic artery reconstruction prevents ischemic graft injury, inhibits graft rejection, and mediates long-term graft acceptance in rat liver transplantation
    E Ishii
    Department of Analytic Human Pathology, Nippon Medical School, Tokyo, Japan
    Transplant Proc 45:1748-53. 2013
    ..Hepatic artery (HA) reconstruction is performed in the clinical liver transplantation...
  19. doi request reprint Predisposition for primary hyperlipidemia in Miniature Schnauzers and Shetland sheepdogs as compared to other canine breeds
    N Mori
    Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 88:394-9. 2010
    ..Gender differences were also observed with regards to severity. In fact, a higher severity was prevalent with female Miniature Schnauzers than their male counterparts whereas it was more balanced between genders for Shetland sheepdogs...
  20. ncbi request reprint Activities of enzymes related to the malate-aspartate shuttle in the blood cells of thoroughbred horses undergoing training exercise
    T Arai
    Division of Veterinary Biochemistry, Nippon Veterinary and Animal Science University, Musashino, Tokyo, Japan
    Vet Res Commun 25:577-83. 2001
    ..This increase in the MDH activity in their WBC is considered to reflect the increased metabolic activity in the race horses resulting from the training...
  21. ncbi request reprint Plasma metabolite concentrations and hepatic enzyme activities in pregnant Romney ewes with restricted feeding
    Y Tanaka
    Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 85:17-21. 2008
    ..Restricted feeding could maintain pregnancy and some plasma metabolites and peripheral leukocyte enzymes may be useful indicators for evaluating metabolic changes in ewes...
  22. doi request reprint Clinical significance of plasma mannose concentrations in healthy and diabetic dogs
    A Mori
    Department of Veterinary Science, Nippon Veterinary and Life Science University, Musashino, Tokyo, 180 8602, Japan
    Vet Res Commun 33:439-51. 2009
    ..Therefore, plasma mannose levels obtained via glucose tolerance testing may be used as a new diagnostic method for evaluating insulin resistance or deficiency in diabetic dogs...
  23. ncbi request reprint Comparison of plasma metabolite concentrations and enzyme activities in beef cattle raised by different feeding systems in Korea, Japan and New Zealand
    A Mori
    Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashiro, Tokyo 180 8602, Japan
    J Vet Med A Physiol Pathol Clin Med 54:342-5. 2007
    ..Plasma metabolite concentrations and energy metabolism-related enzyme activities may be good indicators for evaluating metabolic conditions of beef cattle raised by different feeding systems...
  24. doi request reprint Characterization of the use of liraglutide for glycemic control in healthy and Type 1 diabetes mellitus suffering dogs
    H Oda
    Department of Veterinary Nursing and Technology, School of Veterinary Science Nippon Veterinary and Life Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 95:381-8. 2013
    ..Therefore, liraglutide's prandial glucagon suppressive ability appears to play a key role in its glucose-lowering capability, and offers great potential for use with dogs suffering from T1DM...
  25. doi request reprint Non-targeted analyses of animal plasma: betaine and choline represent the nutritional and metabolic status
    K Katayama
    School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo, Japan
    J Anim Physiol Anim Nutr (Berl) 97:119-25. 2013
    ..The metabolite was identified as betaine by LC-MS/MS. This result indicates that betaine and its metabolic precursor, choline, may be useful biomarkers to evaluate the nutritional and metabolic status of animals...
  26. doi request reprint Obesity induced changes to plasma adiponectin concentration and cholesterol lipoprotein composition profile in cats
    S Muranaka
    School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 91:358-61. 2011
    ..05) in LDL-cholesterol % as compared to age matched healthy control animals. This would indicate that changes in plasma adiponectin concentration and cholesterol lipoprotein composition may be good early indicators of obesity in cats...
  27. ncbi request reprint Changes in activities of enzymes related to energy metabolism in peripheral leukocytes of fattening steers
    N Kimura
    Division of Animal Nutrition, Department of Animal Science, Nippon Veterinary and Animal Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Vet Res Commun 29:19-26. 2005
    ..The cytosolic ratio of MDH/lactate dehydrogenase (LDH) activity in leukocytes increased significantly in the fattening process and was considered to be a useful indicator for evaluating changes in energy metabolism in steers...
  28. ncbi request reprint Changes in metabolite, energy metabolism related enzyme activities and peripheral blood mononuclear cell (PBMC) populations in beef heifers with two differing liveweight change profiles in New Zealand
    A Mori
    Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Vet Res Commun 32:159-66. 2008
    ..Plasma IRI and FFA concentrations, leukocyte cytosolic and mitochondrial MDH activities and CD3 positive and NK cell populations may be useful markers to evaluate metabolic conditions and immunity in the restricted feeding beef heifers...
  29. ncbi request reprint Activities of enzymes in some types of peripheral leucocytes may reflect the differences in nutrient metabolism between dogs and cats
    A Takeguchi
    Department of Veterinary Science, Nippon Veterinary and Animal Science University, Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 78:21-4. 2005
    ..Higher activities of FK, PK and G6PD, which regulate the rate of biosynthesis of fatty acids, may reflect the different characteristics in nutrient metabolism in feline tissues from canine tissues...
  30. ncbi request reprint Cytosolic ratio of malate dehyrogenase/lactate dehydrogenase activity in peripheral leukocytes of race horses with training
    T Arai
    Department of Veterinary Science, Nippon Veterinary and Animal Science University, Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 72:241-4. 2002
    ..Increase in the M/L ratio was considered to reflect elevation of energy metabolism in animal tissues. The M/L ratio may be a useful parameter to evaluate the difference in metabolic states between race horses and riding horses...
  31. doi request reprint Comparison of time-action profiles of insulin glargine and NPH insulin in normal and diabetic dogs
    A Mori
    Department of Veterinary Science, Nippon Veterinary and Life Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Vet Res Commun 32:563-73. 2008
    ..However, co-administration result in hypoglycemia at the dosages tested...
  32. ncbi request reprint Plasma glucose, mannose, and non-esterified fatty acid concentrations in layer-type chickens
    T Sato
    Faculty of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino, Tokyo, Japan
    Br Poult Sci 49:731-5. 2008
    ..3. At the age of 18 and 150 d, plasma glucose concentrations were elevated and plasma mannose and NEFA concentrations were decreased after regular feeding, compared to fasting levels...
  33. doi request reprint Assessing the immune state of dogs suffering from pituitary gland dependent hyperadrenocorticism by determining changes in peripheral lymphocyte subsets
    A Mori
    Department of Veterinary Science, Nippon Veterinary and Life Science University, 1 7 1 Kyonancho, Musashino, Tokyo, 180 8602, Japan
    Vet Res Commun 33:757-69. 2009
    ..PDH dogs may be suffering from an immuno-depressed state as evidenced by significant differences in lymphocyte subset populations. Furthermore, treatment of both PDH and concurrent disease might improve lymphocyte subset distribution...
  34. doi request reprint Effect of glimepiride and nateglinide on serum insulin and glucose concentration in healthy cats
    A Mori
    School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Vet Res Commun 33:957-70. 2009
    ..These findings may provide useful information when choosing a hypoglycemic drug suited for the treatment of diabetic cats depending on the degree of diabetes mellitus the cat is suffering from...
  35. ncbi request reprint The activity ratio of the cytosolic MDH/LDH and the isoenzyme pattern of LDH in the peripheral leukocytes of dogs, cats and rabbits
    T Washizu
    Department of Veterinary Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo, Japan
    Vet Res Commun 26:341-6. 2002
    ..LDH-1 and LDH-2 were dominant in rabbit leukocytes, whereas LDH-5 was dominant in feline leukocytes. It was evident that there were significant differences in energy metabolism between the leukocytes of dogs, rabbits and cats...
  36. doi request reprint The pathological characteristics of acute antibody-mediated rejection in DA-to-Lewis rat orthotopic liver transplantation
    S Kunugi
    Department of Analytic Human Pathology, Nippon Medical School, Tokyo, Japan
    Transplant Proc 43:2737-40. 2011
    ....
  37. doi request reprint Chronic antibody-mediated responses may mediate chronic rejection in rat orthotopic liver transplantation
    A Shimizu
    Department of Pathology, Nippon Medical School, Tokyo, Japan
    Transplant Proc 45:1743-7. 2013
    ..In conclusion, chronic AMR may be involved in chronic rejection of liver transplantations. When chronic AMR was involved in chronic liver graft rejection, typical late morphological changes emerged within a short period...
  38. doi request reprint Effects of metformin on plasma concentrations of glucose and mannose, G6Pase and PEPCK activity, and mRNA expression in the liver and kidney of chickens
    T Sato
    School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Br Poult Sci 52:273-7. 2011
    ..In contrast, no suppression of enzyme activity or mRNA expression was observed in chicken liver. Therefore, the mode of action of metformin, via AMPK activation, may be different in the chicken liver...
  39. doi request reprint Serum glycated albumin: Potential use as an index of glycemic control in diabetic dogs
    T Sako
    Department of Veterinary Nursing, Nippon Veterinary and Life Science University, Musashino, Tokyo, 180 8602, Japan
    Vet Res Commun 33:473-9. 2009
    ..Furthermore, serum GA% can reflect long-term changes (almost 1-3 weeks) in blood glucose concentration and the effect of injected insulin in diabetic dogs...
  40. doi request reprint Decreased gene expression of insulin signaling genes in insulin sensitive tissues of obese cats
    A Mori
    Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1, 7, 1 Kyonancho, Musashino, Tokyo, Japan
    Vet Res Commun 33:315-29. 2009
    ..As such, the monitoring of key insulin signaling genes may have some important diagnostic value to determine the risk level and degree of obesity induced insulin resistance...
  41. ncbi request reprint Effect of supplementation of Agaricus mushroom meal extracts on enzyme activities in peripheral leukocytes of calves
    N Kimura
    Division of Animal Nutrition, Department of Animal Science, Nippon Veterinary and Animals Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 82:7-10. 2007
    ..blazei. It was concluded that supplementation of Agaricus mushroom meal extract was effective in activation of enzymes related to energy metabolism in peripheral leukocytes of calves...
  42. ncbi request reprint Comparison of expression of glucokinase gene and activities of enzymes related to glucose metabolism in livers between dog and cat
    A Tanaka
    Department of Veterinary Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo 180 8602, Japan
    Vet Res Commun 29:477-85. 2005
    ..Expression of GK gene was observed in canine liver and pancreas and feline pancreas with RT-PCR using species specific primers based on the cDNA sequences...
  43. doi request reprint [Lymph node metastasis in superficial squamous carcinoma of the esophagus]
    K Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, and Department of Pathology, Tokyo Metropolitan Geriatric Medical Center, Tokyo, Japan
    Pathologe 34:148-54. 2013
    ....
  44. ncbi request reprint Simultaneous determination of serum mannose and glucose concentrations in dog serum using high performance liquid chromatography
    T Sato
    Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1 7 1 Kyonancho, Musashino, Tokyo 180 8602, Japan
    Res Vet Sci 84:26-9. 2008
    ..This HPLC method may be useful for determination of monosaccharides in animal blood...
  45. doi request reprint Fulminant type 1 diabetes mellitus observed in insulin receptor substrate 2 deficient mice
    T Arai
    Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino, Tokyo, 180 8602, Japan
    Clin Exp Med 8:93-9. 2008
    ..IRS2-deficient mice may be a useful animal model for studying the degradation mechanism of pancreatic beta cells in the process of development of fulminant type 1 DM...
  46. ncbi request reprint Aldehyde dehydrogenase activity in cancer stem cells from canine mammary carcinoma cell lines
    M Michishita
    Department of Veterinary Pathology, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino, Tokyo 180 8602, Japan
    Vet J 193:508-13. 2012
    ..ALDH(high)-derived tumours contained both ALDH(+) and ALDH(-) cells, indicating that these cells had cancer stem cell-like properties...
  47. ncbi request reprint Three-dimensional organization of the hepatic microvasculature in hereditary hemorrhagic telangiectasia
    M Sawabe
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Arch Pathol Lab Med 125:1219-23. 2001
    ..The 3-dimensional reconstruction study of hepatic microvasculature was successful in identifying the pathological changes responsible for the intrahepatic shunts in HHT...
  48. ncbi request reprint Japanese encephalitis - serial CT findings and neuropathology in an autopsy case
    Z Kobayashi
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Clin Neuropathol 28:422-9. 2009
    ..We discussed for the first time the correlation of CT and neuropathological findings in a patient with Japanese encephalitis...
  49. ncbi request reprint Effect of herb supplement on hepatic enzyme activities in ddY mice
    T Arai
    Department of Veterinary Science, Nippon Veterinary and Animal Science University, Musashino, Tokyo, Japan
    Lab Anim 35:288-91. 2001
    ..It was found that dietary herb supplement caused an acceleration of hepatic function, judged by increased activities of glycolytic enzyme and GSHpx in ddY mice...
  50. ncbi request reprint Correlation of telomere lengths in normal and cancers tissue in the large bowel
    K Nakamura
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, 32 5, Sakaecho Itabashi ku, 173 0015, Tokyo, Japan
    Cancer Lett 158:179-84. 2000
    ..Straight, essentially parallel, lines were obtained for the two cases, normal tissue values being about 2 kilobase pairs (kbp) higher, with a significant correlation between data at the individual patient level...
  51. doi request reprint Lymphangiogenesis associated with acute cellular rejection in rat liver transplantation
    E Ishii
    Department of Analytic Human Pathlogy, Nippon Medical School, Tokyo, Japan
    Transplant Proc 42:4282-5. 2010
    ..It may be involved in the resolution of ACR and reduction of inflammation. In severe ACR and AMR, lymphatic vessels were destroyed, which may be involved in persistent severe inflammation...
  52. ncbi request reprint Early squamous cell carcinoma of the oesophagus: the Japanese viewpoint
    K Takubo
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Histopathology 51:733-42. 2007
    ..As a result of advances in the development of endoscopes, pathologists are now expected to diagnose very minute lesions, < 1 mm in size, in the oesophagus...
  53. ncbi request reprint Biological characteristics and chemosensitivity profile of four human anaplastic thyroid carcinoma cell lines
    M Sekiguchi
    EIectro Chemical and Cancer Institute, Chofu, Tokyo, Japan
    Biomed Pharmacother 55:466-74. 2001
    ..This finding indicates that the multidrug resistance of these lines is mediated by a P-glycoprotein-unrelated mechanism. The RT-PCR also presented FAS mRNA in all the lines, and IL-6 and IL-8 mRNAs in some of the lines...
  54. ncbi request reprint The muscles of mastication in the caspian seal (Phoca caspica)
    H Endo
    Department of Zoology, National Science Museum, Tokyo, Japan
    Anat Histol Embryol 31:262-5. 2002
    ....
  55. ncbi request reprint Age-related hypermethylation of the hMLH1 promoter in gastric cancers
    T Nakajima
    Department of Molecular Oncology, Tokyo Medical and Dental University, Tokyo, Japan
    Int J Cancer 94:208-11. 2001
    ..The frequency of hMLH1 methylation significantly increased with age. These results suggest that hMLH1 methylation plays an important role in gastric carcinogenesis in old people...
  56. ncbi request reprint Argyrophilic glial inclusions in the midbrain of patients with Parkinson's disease and diffuse Lewy body disease are immunopositive for NACP/alpha-synuclein
    T Arai
    Department of Neuropathology, Institute of Psychiatry, Tokyo, Japan
    Neurosci Lett 259:83-6. 1999
    ....
  57. ncbi request reprint Expression of a neutrophil chemotactic protein LECT2 in human hepatocytes revealed by immunochemical studies using polyclonal and monoclonal antibodies to a recombinant LECT2
    S Yamagoe
    Department of Bioactive Molecules, National Institute of Infectious Diseases, Tokyo, Japan
    Biochem Biophys Res Commun 237:116-20. 1997
    ..These results indicated that the novel protein was expressed in hepatocytes and suggested an important role of LECT2 in the cells in addition to the activation of neutrophils...
  58. ncbi request reprint Induction of drug metabolism-related enzymes by methylcholanthrene and phenobarbital in transgenic mice carrying human prototype c-Ha-ras gene and their wild type littermates
    Y Ohnishi
    Central Institute for Experimental Animals, 1430 Nogawa, Miyamae ku, Kawasaki shi 216 0001, Japan
    Exp Anim 50:33-9. 2001
    ..These results suggest that the human c-Ha-ras transgene may not affect drug metabolism-related enzymes, and the facilitated carcinogenic response in the Tg-rasH2 mouse is not due to these enzymatic disorders...
  59. ncbi request reprint Implantation of primary cultured adipocytes that secrete insulin modifies blood glucose levels in diabetic mice
    M Ito
    Department of Genome Research and Clinical Application, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba 260 8670, Japan
    Diabetologia 48:1614-20. 2005
    ..The aim of this study was to investigate a procedure for supplementation using genetically engineered, primary-cultured adipocytes in diabetic mice...
  60. ncbi request reprint Increased LDL cholesterol and atherosclerosis in LDL receptor-deficient mice with attenuated expression of scavenger receptor B1
    D Huszar
    Millennium Pharmaceuticals, Inc, Cambridge, MA 02139, USA
    Arterioscler Thromb Vasc Biol 20:1068-73. 2000
    ..These findings suggest that upregulation of the receptor could have therapeutic potential for the treatment of atherosclerosis...
  61. ncbi request reprint The cloning and nucleotide sequence of human ST2L cDNA
    H Li
    Department of Biochemistry, Jichi Medical School, Tochigi, Japan
    Genomics 67:284-90. 2000
    ..We also established stable transfectants of a human glioblastoma cell line, T98G, that express human ST2L constitutively, and we confirmed cell-surface expression of human ST2L protein on the transfectants...
  62. ncbi request reprint The 17-kDa sheath protein in enamel proteins induces cementum regeneration in experimental cavities created in a buccal dehiscence model of dogs
    M Kanazashi
    Department of Periodontics and Endodontics, School of Dental Medicine, Tsurumi University, Yokohama, Japan
    J Periodontal Res 41:193-9. 2006
    ..The purpose of this in vivo study was to identify the cementum regeneration-promoting factor in enamel proteins that is clinically used for periodontal regeneration to induce cementum-promotive and osteopromotive activities...
  63. ncbi request reprint Purification of a new extracellular 90-kDa serine proteinase with isoelectric point of 3.9 from Bacillus subtilis (natto) and elucidation of its distinct mode of action
    T Kato
    Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, Sendai, Japan
    Biosci Biotechnol Biochem 56:1166-8. 1992
    ..The activity was inhibited by phenylmethylsulfonyl fluoride (PMSF) and chymostatin, while the activity was not inhibited by proteinaceous Streptomyces subtilisin inhibitor (SSI) or alpha 2-macroglubulin...
  64. ncbi request reprint Characterization of a novel gene, sperm-tail-associated protein (Stap), in mouse post-meiotic testicular germ cells
    J Ohuchi
    Laboratory of Experimental Animal Science, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Mol Reprod Dev 59:350-8. 2001
    ..We are proposing the name, sperm-tail-associated protein (Stap), for the gene encoding F77 cDNA. Mol. Reprod. Dev. 59: 350-358, 2001...
  65. ncbi request reprint Enhanced expression of rat obese (ob) gene in adipose tissues of ventromedial hypothalamus (VMH)-lesioned rats
    T Funahashi
    Second Department of Internal Medicine, Osaka University, Medical School, Japan
    Biochem Biophys Res Commun 211:469-75. 1995
    ..These data suggest that ob gene might be up-regulated with fat accumulation even in non-genetically obese animals...
  66. ncbi request reprint Roles of the transmembrane domain and the cytoplasmic domain of Fc epsilon RI alpha in immunoglobulin E-mediated up-regulation of surface Fc epsilon RI expression
    Y Okayama
    Research Unit for Allergy Transcriptome, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Yokohama, Japan
    Clin Exp Allergy 37:451-8. 2007
    ..IgE up-regulates Fc epsilon RI alpha expression, but IgG1 does not up-regulate Fc gamma RI alpha expression. The transmembrane domain (TM) of Fc gamma RI alpha determines the stability of cell surface expression of this receptor...
  67. ncbi request reprint The effects of a high-carbohydrate diet on the stress-strain behavior of the periodontal ligament of the distal root of the mandibular first molar in hamsters
    Y Yamazaki
    Department of Periodontics and Endodontics, School of Dental Medicine, Tsurumi University, Yokohama, Japan
    J Periodontal Res 36:301-8. 2001
    ....