Kazuhisa Yamazaki

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. pmc Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile
    Tomoki Maekawa
    Center for Transdisciplinary Research, Niigata University, Niigata, Japan
    PLoS ONE 6:e20240. 2011
  2. pmc Selective expansion of T cells in gingival lesions of patients with chronic inflammatory periodontal disease
    K Yamazaki
    Department of Periodontology, Faculty of Dentistry, Niigata University, Niigata, Japan
    Clin Exp Immunol 120:154-61. 2000
  3. ncbi request reprint Effect of periodontal treatment on the C-reactive protein and proinflammatory cytokine levels in Japanese periodontitis patients
    Kazuhisa Yamazaki
    Periodontology and Immunology, Department of Oral Health and Welfare, Niigata University Faculty of Dentistry, Niigata, Japan
    J Periodontal Res 40:53-8. 2005
  4. pmc Effect of periodontal treatment on the serum antibody levels to heat shock proteins
    K Yamazaki
    Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Clin Exp Immunol 135:478-82. 2004
  5. ncbi request reprint Single-nucleotide polymorphism in the CD14 promoter and periodontal disease expression in a Japanese population
    K Yamazaki
    Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, 5274, Gakkocho Dori 2 ban cho, Niigata 951 8514, Japan
    J Dent Res 82:612-6. 2003
  6. ncbi request reprint T cell regulation of the immune response to infection in periodontal diseases
    K Yamazaki
    Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Histol Histopathol 18:889-96. 2003
  7. ncbi request reprint [Periodontitis and tissue regeneration]
    Kazuhisa Yamazaki
    Periodontology and Oral Immunology, Department of Oral Health and Welfare, Faculty of Dentistry, Niigata University
    Nihon Hotetsu Shika Gakkai Zasshi 49:587-92. 2005
  8. pmc Relationship of periodontal infection to serum antibody levels to periodontopathic bacteria and inflammatory markers in periodontitis patients with coronary heart disease
    K Yamazaki
    Laboratory of Periodontology and Immunology, Department of Oral Health and Welfare, Niigata University Faculty of Dentistry, Niigata, Japan
    Clin Exp Immunol 149:445-52. 2007
  9. pmc Accumulation of human heat shock protein 60-reactive T cells in the gingival tissues of periodontitis patients
    Kazuhisa Yamazaki
    Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Infect Immun 70:2492-501. 2002
  10. ncbi request reprint Interleukin-10 gene promoter polymorphism in Japanese patients with adult and early-onset periodontitis
    K Yamazaki
    Department of Periodontology, Faculty of Dentistry, Niigata University, Niigata, Japan
    J Clin Periodontol 28:828-32. 2001

Collaborators

Detail Information

Publications40

  1. pmc Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile
    Tomoki Maekawa
    Center for Transdisciplinary Research, Niigata University, Niigata, Japan
    PLoS ONE 6:e20240. 2011
    ....
  2. pmc Selective expansion of T cells in gingival lesions of patients with chronic inflammatory periodontal disease
    K Yamazaki
    Department of Periodontology, Faculty of Dentistry, Niigata University, Niigata, Japan
    Clin Exp Immunol 120:154-61. 2000
    ..The results indicate that gingival tissue-infiltrating T cells recognizing a limited number of antigens or epitopes are involved in the disease process...
  3. ncbi request reprint Effect of periodontal treatment on the C-reactive protein and proinflammatory cytokine levels in Japanese periodontitis patients
    Kazuhisa Yamazaki
    Periodontology and Immunology, Department of Oral Health and Welfare, Niigata University Faculty of Dentistry, Niigata, Japan
    J Periodontal Res 40:53-8. 2005
    ..In addition to conventional risk factors, chronic infection and subsequent production of systemic inflammatory markers may be associated with this increased risk...
  4. pmc Effect of periodontal treatment on the serum antibody levels to heat shock proteins
    K Yamazaki
    Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Clin Exp Immunol 135:478-82. 2004
    ....
  5. ncbi request reprint Single-nucleotide polymorphism in the CD14 promoter and periodontal disease expression in a Japanese population
    K Yamazaki
    Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, 5274, Gakkocho Dori 2 ban cho, Niigata 951 8514, Japan
    J Dent Res 82:612-6. 2003
    ....
  6. ncbi request reprint T cell regulation of the immune response to infection in periodontal diseases
    K Yamazaki
    Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Histol Histopathol 18:889-96. 2003
    ..This should not only provide an insight into the relationship between the immune response to periodontopathic bacteria and disease but should also highlight areas of development for potentially new therapeutic modalities...
  7. ncbi request reprint [Periodontitis and tissue regeneration]
    Kazuhisa Yamazaki
    Periodontology and Oral Immunology, Department of Oral Health and Welfare, Faculty of Dentistry, Niigata University
    Nihon Hotetsu Shika Gakkai Zasshi 49:587-92. 2005
    ..In addition, as tissue regenerative potential is negatively regulated by aging, the effects of aging have to be clarified to gain complete regeneration...
  8. pmc Relationship of periodontal infection to serum antibody levels to periodontopathic bacteria and inflammatory markers in periodontitis patients with coronary heart disease
    K Yamazaki
    Laboratory of Periodontology and Immunology, Department of Oral Health and Welfare, Niigata University Faculty of Dentistry, Niigata, Japan
    Clin Exp Immunol 149:445-52. 2007
    ..Identifying the virulence factors of P. gingivalis Su63 may gain insight into the new therapeutic modality for infection-induced deterioration of atherosclerosis...
  9. pmc Accumulation of human heat shock protein 60-reactive T cells in the gingival tissues of periodontitis patients
    Kazuhisa Yamazaki
    Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Infect Immun 70:2492-501. 2002
    ..These results suggest that periodontitis patients have human hsp60-reactive T cells with a type 1 cytokine profile in their peripheral blood T-cell pools...
  10. ncbi request reprint Interleukin-10 gene promoter polymorphism in Japanese patients with adult and early-onset periodontitis
    K Yamazaki
    Department of Periodontology, Faculty of Dentistry, Niigata University, Niigata, Japan
    J Clin Periodontol 28:828-32. 2001
    ..3 dimorphic polymorphisms within the IL-10 gene promoter have recently been identified and appear to influence regulation of its expression...
  11. pmc Elevated proportion of natural killer T cells in periodontitis lesions: a common feature of chronic inflammatory diseases
    K Yamazaki
    Department of Periodontology, Faculty of Dentistry, Niigata University, 5274, Gakkocho Dori 2 ban cho, Niigata 951 8514, Japan
    Am J Pathol 158:1391-8. 2001
    ....
  12. ncbi request reprint T-cell clonality to Porphyromonas gingivalis and human heat shock protein 60s in patients with atherosclerosis and periodontitis
    K Yamazaki
    Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Oral Microbiol Immunol 19:160-7. 2004
    ..Furthermore, these HSP60-reactive T cells seemed to be present in atherosclerotic lesions in some patients. These results suggest that T-cell clones with the same specificity may be involved in the pathogenesis of the different diseases...
  13. ncbi request reprint Association of tumor necrosis factor receptor type 2 +587 gene polymorphism with severe chronic periodontitis
    Yasuko Shimada
    Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Clin Periodontol 31:463-9. 2004
    ..Tumor necrosis factor receptor 2 (TNFR2) is one of the cell surface receptors for TNF-alpha. Recent studies have suggested that TNFR2 gene polymorphism is involved in autoimmune and other diseases...
  14. doi request reprint Effects of systemic sitafloxacin on periodontal infection control in elderly patients
    Takako Nakajima
    Center for Transdisciplinary Research, Niigata University, Niigata, Japan
    Gerodontology 29:e1024-32. 2012
    ..To evaluate the microbiological and clinical effects of the systemic administration of sitafloxacin (STFX) on periodontal pockets in elderly patients receiving supportive periodontal therapy (SPT)...
  15. pmc Effect of Porphyromonas gingivalis infection on post-transcriptional regulation of the low-density lipoprotein receptor in mice
    Haruna Miyazawa
    Center for Transdisciplinary Research, Niigata University, 5274 Gakkocho 2 ban cho, Niigata, 951 8514, Japan
    Lipids Health Dis 11:121. 2012
    ..Here, we explored whether Porphyromonas gingivalis, a representative periodontopathic bacterium, -induced inflammatory response regulates serum PCSK9 and cholesterol levels using animal models...
  16. doi request reprint Relationship between serum antibody titres to Porphyromonas gingivalis and hs-CRP levels as inflammatory markers of periodontitis
    Hirotaka Miyashita
    Center for Transdisciplinary Research, Niigata University, Niigata 9518514, Japan
    Arch Oral Biol 57:820-9. 2012
    ....
  17. ncbi request reprint Matrix metalloproteinase-1 and -3 gene promoter polymorphisms in Japanese patients with periodontitis
    Manami Itagaki
    Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Clin Periodontol 31:764-9. 2004
    ..The aim of this study was to investigate whether these gene promoter polymorphisms were associated with the susceptibility to periodontitis...
  18. doi request reprint Elevated expression of IL-17 and IL-12 genes in chronic inflammatory periodontal disease
    Tomoyuki Honda
    Center for Transdisciplinary Research, Niigata University, Niigata, Japan
    Clin Chim Acta 395:137-41. 2008
    ..We compared the gene expression profile of Th17-related molecules in gingivitis and periodontitis lesions showing distinct clinical entities...
  19. doi request reprint Porphyromonas gingivalis antigens and interleukin-6 stimulate the production of monocyte chemoattractant protein-1 via the upregulation of early growth response-1 transcription in human coronary artery endothelial cells
    Tomoki Maekawa
    Center for Transdisciplinary Research, Niigata University, Niigata 951 8514, Japan
    J Vasc Res 47:346-54. 2010
    ..However, it is not known whether periodontal infection affects the expression of Egr-1 and subsequent endothelial cells expression of monocyte chemoattractant protein (MCP)-1, a key molecule of leukocyte chemoattraction into vessels...
  20. doi request reprint Increased expression of C-reactive protein gene in inflamed gingival tissues could be derived from endothelial cells stimulated with interleukin-6
    Tomoki Maekawa
    Center for Transdisciplinary Research, Niigata University, 2 5274 Gakko cho, Chuo Ku, Niigata 951 8514, Japan
    Arch Oral Biol 56:1312-8. 2011
    ..However, the underlying mechanism of CRP production in the periodontal tissues has not been fully elucidated. Therefore, the aim of the present study was to clarify the mechanism of CRP production in periodontal tissues...
  21. doi request reprint Up-regulation of the endoplasmic reticulum stress-response in periodontal disease
    Hisanori Domon
    Department of Oral Health and Welfare, Laboratory of Periodontology and Immunology, Niigata University Faculty of Dentistry, Japan
    Clin Chim Acta 401:134-40. 2009
    ..However, the relationship between ER stress and periodontal disease is yet to be determined...
  22. doi request reprint Increased serum PCSK9 concentrations are associated with periodontal infection but do not correlate with LDL cholesterol concentration
    Haruna Miyazawa
    Center for Transdisciplinary Research, Niigata University, Chu o ku, Niigata, Japan
    Clin Chim Acta 413:154-9. 2012
    ..The aim of the present study is to analyze serum PCSK9 concentrations and their relation to lipoprotein concentrations in periodontitis patients...
  23. ncbi request reprint Effects of Nd:YAG and CO2 laser treatment and ultrasonic scaling on periodontal pockets of chronic periodontitis patients
    Akira Miyazaki
    Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Periodontol 74:175-80. 2003
    ....
  24. doi request reprint Porphyromonas gingivalis lipopolysaccharide induces miR-146a without altering the production of inflammatory cytokines
    Tomoyuki Honda
    Center for Transdisciplinary Research, Niigata University, Niigata, Japan
    Biochem Biophys Res Commun 420:918-25. 2012
    ..gingivalis LPS. Because TLR signaling induces various negative regulators, these results call into question the role of miR-146a in cells stimulated with TLR ligands...
  25. ncbi request reprint Elevated antibody titers to Porphyromonas gingivalis as a possible predictor of ischemic vascular disease - results from the Tokamachi-Nakasato cohort study
    Koichi Tabeta
    Center for Transdisciplinary Research, Niigata University, Niigata, Japan
    J Atheroscler Thromb 18:808-17. 2011
    ..We investigated this relationship in a Japanese cohort by measuring serum titers of antibodies to periodontopathic bacteria...
  26. ncbi request reprint Early and preferential induction of IL-1 receptor-associated kinase-M in THP-1 cells by LPS derived from Porphyromonas gingivalis
    Hisanori Domon
    Laboratory of Periodontology and Immunology, Department of Oral Health and Welfare, Faculty of Dentistry, Niigata University, 5274 Gakkocho 2 ban cho, Chu o ku, Niigata, Japan
    J Leukoc Biol 83:672-9. 2008
    ..This activity may be involved in the chronic infection of this bacterium in periodontal tissue by serving as an escape mechanism from immune surveillance...
  27. ncbi request reprint Association of interleukin-1 receptor antagonist gene polymorphisms with early onset periodontitis in Japanese
    Hideaki Tai
    Department of Periodontology, Faculty of Dentistry, Niigata University, Niigata, Japan
    J Clin Periodontol 29:882-8. 2002
    ....
  28. doi request reprint Effect of interleukin-17 on the expression of chemokines in gingival epithelial cells
    Naoki Takahashi
    Center for Transdisciplinary Research, Niigata University, Japan
    Eur J Oral Sci 119:339-44. 2011
    ..In conclusion, IL-17 is involved in the regulation of the innate immune response in HGECs by inducing CXCL8 production...
  29. doi request reprint Assessment of chromosome 19 for genetic association in severe chronic periodontitis
    Koichi Tabeta
    Center for Transdisciplinary Research, Niigata University, Niigata, Japan
    J Periodontol 80:663-71. 2009
    ..We designed a study using the DNA pooling method, which could be a breakthrough in lowering such costs. This study was conducted to assess the genetic association in severe CP in a Japanese population...
  30. ncbi request reprint Antigen specificity and T-cell clonality in periodontal disease
    Kazuhisa Yamazaki
    Department of Oral Biological Science, Graduate School of Medical and Dental Sciences, Niigata University, Japan
    Periodontol 2000 35:75-100. 2004
  31. doi request reprint Periodontal disease and risk of atherosclerotic coronary heart disease
    Takako Nakajima
    Center for Transdisciplinary Research, Niigata University, Niigata 951 8514, Japan
    Odontology 97:84-91. 2009
    ..Here we review whether periodontitis represents a risk factor for CHD or atherosclerosis, particularly in a Japanese population...
  32. doi request reprint Analysis of immune responses to purified recombinant antigens of periodontal pathogens
    Koichi Tabeta
    Center for Transdisciplinary Research, Niigata University, Niigata, Japan
    Methods Mol Biol 666:345-57. 2010
    ..The recombinant proteins allowed us to evaluate the immune response to these antigens in periodontitis patients...
  33. doi request reprint Analysis of immunostimulatory activity of Porphyromonas gingivalis fimbriae conferred by Toll-like receptor 2
    Yukari Aoki
    Center for Transdisciplinary Research, Niigata University, Niigata, Japan
    Biochem Biophys Res Commun 398:86-91. 2010
    ..These results suggest that lipoproteins or lipopeptides associated with FimA fimbriae could at least in part account for signaling via TLR2 and subsequent TNF-alpha production in macrophages...
  34. doi request reprint Single-strand conformation polymorphism analysis for the diagnosis of T-cell clonality in periodontal disease
    Kazuhisa Yamazaki
    Center for Transdisciplinary Research, Niigata University, Niigata, Japan
    Methods Mol Biol 666:359-72. 2010
    ..SSCP is a powerful tool for analyzing specific T-cell responses both in vitro and in vivo...
  35. ncbi request reprint The effects of Porphyromonas gingivalis LPS and Actinobacillus actinomycetemcomitans LPS on human dendritic cells in vitro, and in a mouse model in vivo
    Rangsini Mahanonda
    Department of Periodontology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand
    Asian Pac J Allergy Immunol 24:223-8. 2006
    ..In conclusion, stimulation by P. gingivalis LPS and A. actinomycetemcomitans LPS appears to bias Mo-DCs towards Th2 production...
  36. ncbi request reprint Vascular endothelial growth factor and transforming growth factor-alpha and -beta1 are released from human cultured gingival epithelial sheets
    Manabu Momose
    Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Japan
    J Periodontol 73:748-53. 2002
    ..The purpose of this study was to measure the levels of growth factors released from HCGES into culture medium...
  37. doi request reprint Th2 cytokines efficiently stimulate periostin production in gingival fibroblasts but periostin does not induce an inflammatory response in gingival epithelial cells
    Mayuka Nakajima
    Laboratory of Periodontology and Immunology, Division of Oral Science for Health Promotion, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Arch Oral Biol 59:93-101. 2014
    ..This study aims to clarify whether gingival fibroblasts produce periostin in response to Th2 cytokines which are elevated in periodontitis lesion and, if so, whether periostin affects the inflammatory response and matrix-protein metabolism...
  38. ncbi request reprint Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota
    Kei Arimatsu
    1 Laboratory of Periodontology and Immunology, Division of Oral Science for Health Promotion, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan 2 Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Sci Rep 4:4828. 2014
    ..These results provide a new paradigm for the interrelationship between periodontitis and systemic diseases. ..
  39. ncbi request reprint Cardiovascular and oral disease interactions: what is the evidence?
    Pauline J Ford
    Oral Biology and Pathology, School of Dentistry, University of Queensland, Brisbane, Australia
    Prim Dent Care 14:59-66. 2007
    ..This may be of significant benefit to cardiovascular health and enables members of the oral health team to contribute to their patients' general health...
  40. ncbi request reprint The role of T cells in periodontal disease: homeostasis and autoimmunity
    Erica Gemmell
    Oral Biology and Pathology, School of Dentistry, University of Queensland, Brisbane, Australia
    Periodontol 2000 43:14-40. 2007