Tadashi Yamamoto

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. ncbi Integrated view of the human chromosome X-centric proteome project
    Tadashi Yamamoto
    Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Proteome Res 12:58-61. 2013
  2. ncbi Expression of AQP family in rat kidneys during development and maturation
    T Yamamoto
    Department of Pathology, Institute of Nephrology, Niigata University School of Medicine, Japan
    Am J Physiol 272:F198-204. 1997
  3. ncbi Molecular cloning of a new aquaporin from rat pancreas and liver
    Y Koyama
    Department of Pathology, Institute of Nephrology, Niigata University School of Medicine, 1 757 Asahimachi dori, Niigata 951, Japan
    J Biol Chem 272:30329-33. 1997
  4. ncbi Proteomics database in chronic kidney disease
    Tadashi Yamamoto
    Institute of Nephrology, Structural Pathology, Chuo Ku Niigata, Niigata, Japan
    Adv Chronic Kidney Dis 17:487-92. 2010
  5. ncbi Towards standard protocols and guidelines for urine proteomics: a report on the Human Kidney and Urine Proteome Project (HKUPP) symposium and workshop, 6 October 2007, Seoul, Korea and 1 November 2007, San Francisco, CA, USA
    Tadashi Yamamoto
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata, Japan
    Proteomics 8:2156-9. 2008
  6. ncbi Glomerular proteins related to slit diaphragm and matrix adhesion in the foot processes are highly tyrosine phosphorylated in the normal rat kidney
    Ying Zhang
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Nephrol Dial Transplant 25:1785-95. 2010
  7. ncbi Claudin-6 localized in tight junctions of rat podocytes
    Linning Zhao
    Department of Structural Pathology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, Japan
    Am J Physiol Regul Integr Comp Physiol 294:R1856-62. 2008
  8. ncbi Important role for macrophages in induction of crescentic anti-GBM glomerulonephritis in WKY rats
    Masato Isome
    Department of Structural Pathology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachi-dori-1-bancho, Niigata 951-8510, Japan
    Nephrol Dial Transplant 19:2997-3004. 2004
  9. ncbi Expression of SM22α (transgelin) in glomerular and interstitial renal injury
    Shigeru Inomata
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Nephron Exp Nephrol 117:e104-13. 2011
  10. ncbi Upregulation of nestin, vimentin, and desmin in rat podocytes in response to injury
    Jun Zou
    Department of Structural Pathology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Virchows Arch 448:485-92. 2006

Collaborators

Detail Information

Publications65

  1. ncbi Integrated view of the human chromosome X-centric proteome project
    Tadashi Yamamoto
    Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Proteome Res 12:58-61. 2013
    ....
  2. ncbi Expression of AQP family in rat kidneys during development and maturation
    T Yamamoto
    Department of Pathology, Institute of Nephrology, Niigata University School of Medicine, Japan
    Am J Physiol 272:F198-204. 1997
    ..The progressive induction of AQP2 expression in the first 4 wk after birth is presumed to contribute to the maturation of urinary concentrating capacity during the kidney development...
  3. ncbi Molecular cloning of a new aquaporin from rat pancreas and liver
    Y Koyama
    Department of Pathology, Institute of Nephrology, Niigata University School of Medicine, 1 757 Asahimachi dori, Niigata 951, Japan
    J Biol Chem 272:30329-33. 1997
    ..By in situ hybridization, AQP8 mRNA expression was assumed in hepatocytes, acinal cells of pancreas and salivary gland, and absorptive colonic epithelial cells. The physiological role(s) of AQP8 remain to be elucidated...
  4. ncbi Proteomics database in chronic kidney disease
    Tadashi Yamamoto
    Institute of Nephrology, Structural Pathology, Chuo Ku Niigata, Niigata, Japan
    Adv Chronic Kidney Dis 17:487-92. 2010
    ....
  5. ncbi Towards standard protocols and guidelines for urine proteomics: a report on the Human Kidney and Urine Proteome Project (HKUPP) symposium and workshop, 6 October 2007, Seoul, Korea and 1 November 2007, San Francisco, CA, USA
    Tadashi Yamamoto
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata, Japan
    Proteomics 8:2156-9. 2008
    ..An initial draft of standard protocols and guidelines for proteome analysis of non-proteinuric urine (urine protein excretion < or =150 mg/day) will soon be released as the first HKUPP product...
  6. ncbi Glomerular proteins related to slit diaphragm and matrix adhesion in the foot processes are highly tyrosine phosphorylated in the normal rat kidney
    Ying Zhang
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Nephrol Dial Transplant 25:1785-95. 2010
    ..To understand the involvement of tyrosine phosphorylation in kidney functions, a comprehensive proteomic study for tyrosine-phosphorylated proteins was performed in the normal rat kidney...
  7. ncbi Claudin-6 localized in tight junctions of rat podocytes
    Linning Zhao
    Department of Structural Pathology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, Japan
    Am J Physiol Regul Integr Comp Physiol 294:R1856-62. 2008
    ..These findings indicate that claudin-6 is a transmembrane protein of tight junctions in podocytes during development and under pathological conditions...
  8. ncbi Important role for macrophages in induction of crescentic anti-GBM glomerulonephritis in WKY rats
    Masato Isome
    Department of Structural Pathology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachi-dori-1-bancho, Niigata 951-8510, Japan
    Nephrol Dial Transplant 19:2997-3004. 2004
    ..CONCLUSION: These results indicate that Mo/Mphi play an important role in the induction of crescentic anti-GBM GN and glomerular injury...
  9. ncbi Expression of SM22α (transgelin) in glomerular and interstitial renal injury
    Shigeru Inomata
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Nephron Exp Nephrol 117:e104-13. 2011
    ..In this study, we investigated SM22α expression in models of glomerular and interstitial renal injury...
  10. ncbi Upregulation of nestin, vimentin, and desmin in rat podocytes in response to injury
    Jun Zou
    Department of Structural Pathology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Virchows Arch 448:485-92. 2006
    ..An upregulation of IF proteins may increase the mechanical stability of cells, thus enabling podocytes to undergo morphological changes on the tensile glomerular capillary wall...
  11. ncbi Genomic and non-genomic regulation of L-type calcium channels in rat ventricle by thyroid hormone
    Hiroshi Watanabe
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan
    Endocr Res 31:59-70. 2005
    ..These genomic and non-genomic modifications may play an important role in the association of high cardiac output with low exercise tolerance, and in the development of heart failure in hyperthyroidism...
  12. ncbi FR167653 suppresses the progression of experimental autoimmune myocarditis
    Seitaro Maruyama
    First Department of Internal Medicine, Institute of Nephrology, Niigata University School of Medicine, Niigata, Japan
    Mol Cell Biochem 246:39-44. 2003
    ..However, mRNA of TNF-alpha was not detected in any groups. Our results suggest that FR167653 suppresses the development of myocarditis by suppression of IL-1beta...
  13. ncbi Mesangial cells connected by the N-cadherin-catenin system in the rat kidney
    Masaaki Nameta
    Cooperative Laboratory of Electron Microscopy, Niigata University, Niigata, Japan
    Nephron Exp Nephrol 112:e92-8. 2009
    ..We previously reported alpha- and beta-catenins localized at the cell-cell contact sites of mesangial cells in the rat. Classical cadherin expressed by mesangial cells, however, remains to be elucidated...
  14. ncbi Identification and localization of novel genes preferentially expressed in human kidney glomerulus
    Lino Munoz Cuellar
    Department of Structural Pathology, Institute of Nephrology, Niigata University, Japan
    Nephrology (Carlton) 14:94-104. 2009
    ....
  15. ncbi Comparison of two dimensional electrophoresis mouse colon proteomes before and after knocking out Aquaporin 8
    Sameh Magdeldin
    Department of Structural Pathology Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, 1 757 Asahimachi dori, Japan
    J Proteomics 73:2031-40. 2010
    ..Our analysis revealed identification and regulation of 21 proteins, most notably, actin-related family which suggests its possible involvement in regulating AQP8 secretory vesicles migration to be integrated as a cell membrane protein...
  16. ncbi Role of Fat1 in cell-cell contact formation of podocytes in puromycin aminonucleoside nephrosis and neonatal kidney
    Eishin Yaoita
    Department of Structural Pathology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Kidney Int 68:542-51. 2005
    ..To gain insight into its role in podocytes, we expanded our study of Fat1 expression to puromycin aminonucleoside (PAN) nephrosis, the neonatal kidney, and the primary podocyte culture, where slit diaphragms are absent or disappear...
  17. ncbi Quantitative histological analysis of SM22α (transgelin) in an adriamycin-induced focal segmental glomerulosclerosis model
    Xingzhi Wang
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Nephron Exp Nephrol 120:e1-11. 2012
    ..In this study, quantitative analyses of SM22α positivity were performed to investigate the pathological significance of its expression...
  18. ncbi Thyroid hormone regulates mRNA expression and currents of ion channels in rat atrium
    Hiroshi Watanabe
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Science, 1 754 Asahimachidori, Niigata, Japan
    Biochem Biophys Res Commun 308:439-44. 2003
    ..In conclusion, T3 increased the outward currents and decreased the inward currents. The resultant changes of ionic currents shortened APD, providing a substrate for atrial fibrillation...
  19. ncbi Molecular characterization of water-selective AQP (EbAQP4) in hagfish: insight into ancestral origin of AQP4
    Goro Nishimoto
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Am J Physiol Regul Integr Comp Physiol 292:R644-51. 2007
    ..These observations suggest that EbAQP4 is an ancestral water channel of mammalian AQP4 and plays a role in basolateral water transport in the gill pavement cells...
  20. ncbi Periglomerular accumulation of dendritic cells in rat crescentic glomerulonephritis
    Hidehiko Fujinaka
    Department of Structural Pathology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata Japan
    J Nephrol 20:357-63. 2007
    ..This study aimed to demonstrate that periglomerular OX-6+ cells are dendritic cells (DCs) and to clarify their roles in the pathogenesis of this GN...
  21. ncbi Fc receptor-mediated accumulation of macrophages in crescentic glomerulonephritis induced by anti-glomerular basement membrane antibody administration in WKY rats
    Pavel Kovalenko
    Department of Structural Pathology, Institute of Nephrology, Japan
    Int Immunol 16:625-34. 2004
    ..These studies provide direct evidence for a crucial involvement of IgG Fc-FcgammaR interaction in glomerular recruitment of macrophages and following induction of anti-GBM glomerulonephritis in WKY rats...
  22. ncbi Expression of MMP-9 in mesangial cells and its changes in anti-GBM glomerulonephritis in WKY rats
    Tadahide Kuroda
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Clin Exp Nephrol 8:206-15. 2004
    ....
  23. ncbi Up-regulation of connexin43 in glomerular podocytes in response to injury
    Eishin Yaoita
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Japan
    Am J Pathol 161:1597-606. 2002
    ..Thus, it is concluded that Cx43-mediated GJIC is present between podocytes, suggesting that podocytes may respond to injury as an integrated epithelium on a glomerulus rather than individually as a separate cell...
  24. ncbi Novel expression of claudin-5 in glomerular podocytes
    Ryo Koda
    Department of Structural Pathology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Cell Tissue Res 343:637-48. 2011
    ....
  25. ncbi Expression of the cartilage derived anti-angiogenic factor chondromodulin-I decreases in the early stage of experimental osteoarthritis
    Tadashi Hayami
    Department of Orthopedic Surgery, Niigata University School of Medicine (NUSM, Niigata, Japan
    J Rheumatol 30:2207-17. 2003
    ..These findings suggest the loss of ChM-I from articular cartilage might be responsible in part for promoting blood vessel invasion into the cartilage during progression of OA...
  26. ncbi Murine colon proteome and characterization of the protein pathways
    Sameh Magdeldin
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    BioData Min 5:11. 2012
    ..abstract:..
  27. ncbi Expression of the chemokine fractalkine (FKN/CX3CL1) by podocytes in normal and proteinuric rat kidney glomerulus
    Koichi Katsuyama
    Department of Structural Pathology, Institute of Nephrology, Niigata University, Niigata, Japan
    Nephron Exp Nephrol 113:e45-56. 2009
    ..The purpose of this study is to examine the expression and localization of FKN/CX3CL1 in normal and proteinuric glomeruli...
  28. ncbi In-depth proteomic profiling of the normal human kidney glomerulus using two-dimensional protein prefractionation in combination with liquid chromatography-tandem mass spectrometry
    Masahito Miyamoto
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    J Proteome Res 6:3680-90. 2007
    ....
  29. ncbi Identification and characterization of major proteins carrying ABO blood group antigens in the human kidney
    Masayuki Tasaki
    Department of Structural Pathology, Institute of Nephrology, Niigata Graduate School of Medical and Dental Sciences, Niigata, Japan
    Transplantation 87:1125-33. 2009
    ..Although glycolipids carrying ABO antigens have been well characterized in human kidneys, glycoproteins carrying ABO antigens are largely unknown, and their molecular properties remain to be elucidated...
  30. ncbi Injured kidney cells express SM22α (transgelin): Unique features distinct from α-smooth muscle actin (αSMA)
    Yuichi Sakamaki
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Nephrology (Carlton) 16:211-8. 2011
    ..The SM22α expression in the rat anti-glomerular basement membrane (GBM) nephritis model and differences from an established phenotypic marker for the myofibroblast, α-smooth muscle actin (αSMA), were investigated...
  31. ncbi Suppression of experimental crescentic glomerulonephritis by interleukin-10 gene transfer
    Adel G A El-Shemi
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Kidney Int 65:1280-9. 2004
    ..Investigated were effects of overexpression of interleukin-10 (IL-10) on the outcome and progression of crescentic glomerulonephritis in Wistar-Kyoto (WKY) rats...
  32. ncbi Quinapril inhibits progression of heart failure and fibrosis in rats with dilated cardiomyopathy after myocarditis
    Wen Juan
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Mol Cell Biochem 251:77-82. 2003
    ..Furthermore, myocardial fibrosis was regressed and myocardial structure returned to nearly normal in animals treated with quinapril...
  33. ncbi Expression and localization of two isoforms of AQP10 in human small intestine
    Huiping Li
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Biol Cell 97:823-9. 2005
    ..In the present study, we investigated the expression and localization of these AQP10 isoforms...
  34. ncbi Usage of electrostatic eliminator reduces human keratin contamination significantly in gel-based proteomics analysis
    Bo Xu
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    J Proteomics 74:1022-9. 2011
    ..We herein proposed a series of methods for improving experimental conditions and sample treatment in order to minimize the keratin contamination in an economical and practical way...
  35. ncbi Coxsackievirus and adenovirus receptor, a tight junction membrane protein, is expressed in glomerular podocytes in the kidney
    Maki Nagai
    Department of Structural Pathology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Lab Invest 83:901-11. 2003
    ..These findings indicate that CAR is an integral membrane component of tight junction in podocytes and that CAR expression in podocytes is regulated at the transcriptional level and in the redistribution of protein...
  36. ncbi Overview of kidney and urine proteome databases
    Yutaka Yoshida
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Contrib Nephrol 160:186-97. 2008
    ..We then update the current status of available protein databases of kidney and urine proteomes...
  37. ncbi Two-dimensional electrophoretic profiling of normal human kidney glomerulus proteome and construction of an extensible markup language (XML)-based database
    Yutaka Yoshida
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Proteomics 5:1083-96. 2005
    ..The database is deposited on a web site (http://www.sw.nec.co.jp/bio/rd/hgldb/index.html) in a form accessible to researchers to contribute to proteomic studies of human glomerulus in health and disease...
  38. ncbi Differential proteomic shotgun analysis elucidates involvement of water channel aquaporin 8 in presence of α-amylase in the colon
    Sameh Magdeldin
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Japan
    J Proteome Res 9:6635-46. 2010
    ..Here, we also proved the capability of our coupled approaches for selecting the most reliable and significant candidates, an applicable process for initial screening of biological biomarkers in complex specimens and tissue extracts...
  39. ncbi Profiling and annotation of human kidney glomerulus proteome
    Zenyui Cui
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Proteome Sci 11:13. 2013
    ....
  40. ncbi Proteomic approach to human kidney glomerulus prepared by laser microdissection from frozen biopsy specimens: exploration of proteome after removal of blood-derived proteins
    Yutaka Yoshida
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Japan
    Proteomics Clin Appl 6:412-7. 2012
    ..We attempted to establish experimental platform for in-depth proteomic analysis of glomeruli by removal of blood-derived proteins from frozen biopsy samples...
  41. ncbi Extensive proteomic profiling of the secretome of European community acquired methicillin resistant Staphylococcus aureus clone
    Shymaa Enany
    Department of Structural Pathology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Peptides 37:128-37. 2012
    ..Among them, 52% proteins were predicted to be secreted through signal peptide-independent pathways. Most notably, the expression of some proteins such as enterotoxins U and B were identified for the first time in this clone...
  42. ncbi Comparison of human glomerulus proteomic profiles obtained from low quantities of samples by different mass spectrometry with the comprehensive database
    Ying Zhang
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Proteome Sci 9:47. 2011
    ..abstract:..
  43. ncbi Human kidney glomerulus proteome and biomarker discovery of kidney diseases
    Yutaka Yoshida
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Proteomics Clin Appl 2:420-7. 2008
    ..In this review, we attempt to outline the current status of clinical proteomics of the glomerulus and provide a perspective of protein biomarker discovery of glomerular diseases...
  44. ncbi Localization and expression of chondromodulin-I in the rat cornea
    Atsushi Fukushima
    Department of Structural Pathology, Institute of Nephrology, and Division of Ophthalmology and Visual Sciences, Course for Biological Functions and Medical Control, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Arch Histol Cytol 66:445-52. 2003
    ..ChM-I in the corneal epithelial layer may prevent neovascularization and maintain avascularity in the cornea...
  45. ncbi Novel expression of sodium/myo-inositol co-transporter in podocytes in puromycin aminonucleoside nephrosis
    Yusuke Watanabe
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Niigata, 951-8510, Japan
    Nephrol Dial Transplant 19:817-22. 2004
    ..CONCLUSIONS: These findings suggest that SMIT expression in podocytes is not provoked by an effect of massive proteinuria but by extensive cellular injury...
  46. ncbi Chondromodulin-I expression in rat articular cartilage
    Hiroshi Kitahara
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Arch Histol Cytol 66:221-8. 2003
    ..The avascular condition may be preserved by angiogenic inhibitors or mechanisms other than ChM-I in the mature articular cartilage...
  47. ncbi Cadherin and catenin staining in podocytes in development and puromycin aminonucleoside nephrosis
    Eishin Yaoita
    Department of Structural Pathology, Institute of Nephrology, Faculty of Medicine, Niigata University, Niigata, Japan
    Nephrol Dial Transplant 17:16-9. 2002
    ..These results indicate that the composition of intercellular junction molecules of podocytes in the adult is different from that of immature podocytes even under the pathological condition...
  48. ncbi Involvement of endothelial cell adhesion molecules in the development of anti-Thy-1 nephritis
    Masato Isome
    Department of Structural Pathology, Institute of Nephrology, Faculty of Medicine, Niigata University, Niigata, Japan
    Exp Nephrol 10:338-47. 2002
    ....
  49. ncbi Time course of gene expression in rat experimental autoimmune myocarditis
    Haruo Hanawa
    First Department of Internal Medicine, Niigata University School of Medicine, Asahimachi 1 754, Niigata, 951 8510, Japan
    Clin Sci (Lond) 103:623-32. 2002
    ..RAA system and ET expressions are changed differently during the EAM time course. Cytokine, chemokine and extracellular matrix greatly increase and, in particular, large numbers of osteopontin mRNA are expressed in early EAM...
  50. ncbi Dietary supplementation with arachidonic acid but not eicosapentaenoic or docosahexaenoic acids alter lipids metabolism in C57BL/6J mice
    Sameh Magdeldin
    Department of Physiology, Faculty of Veterinary Medicine, Suez Canal University, Egypt
    Gen Physiol Biophys 28:266-75. 2009
    ..Moreover, the coincidently structural changes observed in liver of this group direct us to call for further studies to investigate the anti-obesity effect and safety of these PUFA under high supplementation condition...
  51. ncbi Toward deciphering proteomes of formalin-fixed paraffin-embedded (FFPE) tissues
    Sameh Magdeldin
    Department of Structural Pathology Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Japan
    Proteomics 12:1045-58. 2012
    ..Unlocking the proteomic profile of clinicopathological FFPE tissues is a critically essential step for annotating clinical findings and predicting biomarkers for ultimate disease prognosis and therapeutic follow-up...
  52. ncbi Osteopontin expression in acute renal allograft rejection
    Bassam Alchi
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Kidney Int 67:886-96. 2005
    ..Osteopontin (OPN) is a potent chemoattractant for mononuclear cells that is up-regulated in various inflammatory states of the kidney. The role of OPN and its expression in human renal allograft rejection are unknown...
  53. ncbi Suppression of myocardial inflammation using suramin, a growth factor blocker
    Takaaki Shiono
    First Department of Internal Medicine, Institute of Nephrology, Niigata University School of Medicine, Japan
    Circ J 66:385-9. 2002
    ..Suramin suppressed myocardial inflammation in EAM and was associated with modulation of the Th1/Th2 cytokine milieu and reduced TGF-beta1 expression in the heart...
  54. ncbi The promotional effect of IL-22 on mineralization activity of periodontal ligament cells
    Nahoko Kato-Kogoe
    Department of Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    Cytokine 59:41-8. 2012
    ..This study investigated the biological effects of IL-22 on periodontal ligament (PDL) cells as part of studies to assess the involvement of IL-22 in periodontal disease...
  55. ncbi Gene expression profiling of advanced-stage serous ovarian cancers distinguishes novel subclasses and implicates ZEB2 in tumor progression and prognosis
    Kosuke Yoshihara
    Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Cancer Sci 100:1421-8. 2009
    ..These findings suggest that the expression of epithelial-mesenchymal transition-related genes such as ZEB2 and CDH1 may play important roles in the invasion process of advanced stage serous ovarian cancer...
  56. ncbi The 4th Human Kidney and Urine Proteome Project (HKUPP) workshop. 26 September 2009, Toronto, Canada
    Tadashi Yamamoto
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Proteomics 10:2069-70. 2010
    ..The 4th workshop held in September 2009 discussed problems of proteomics analysis for kidney tissues and urine samples and a standard protocol for collection, storage and protein concentration of urine samples was decided upon...
  57. ncbi Different gene expression of potassium channels by thyroid hormone and an antithyroid drug between the atrium and ventricle of rats
    Mei Lei Ma
    Department of Clinical Pharmacology, Niigata College of Pharmacology, Niigata University, Asahimachi, Niigata, Japan
    Jpn Heart J 44:101-10. 2003
    ....
  58. ncbi [Structure and function of mesangium]
    Tadashi Yamamoto
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University
    Nippon Rinsho 64:65-9. 2006
  59. ncbi Extracellular heat shock protein A9 is a novel interaction partner of podoplanin in oral squamous cell carcinoma cells
    Masayuki Tsuneki
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Biochem Biophys Res Commun 434:124-30. 2013
    ..In conclusion, the results indicate that HSPA9 secreted by oral SCC cells interacts with PDPN on their cell surface in an autocrine manner and regulates their growth and invasiveness...
  60. ncbi Evidence for megalin-mediated proximal tubular uptake of L-FABP, a carrier of potentially nephrotoxic molecules
    Yuko Oyama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Lab Invest 85:522-31. 2005
    ..These results suggest a novel renal uptake pathway for L-FABP, a carrier of hydrophobic molecules, some of which may exert nephrotoxic effects...
  61. ncbi [Structure and function of collecting duct]
    Eishin Yaoita
    Department of Structural Pathology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences
    Nippon Rinsho 64:98-102. 2006
  62. ncbi Fenofibrate, a peroxisome proliferator-activated receptor alpha activator, suppresses experimental autoimmune myocarditis by stimulating the interleukin-10 pathway in rats
    Seitaro Maruyama
    First Department of Internal Medicine, Niigata University School of Medicine, Japan
    J Atheroscler Thromb 9:87-92. 2002
    ..620). We suggest that PPARalpha activators may prevent the progression of myocarditis through increased expression of the gene encoding the anti-inflammatory cytokine IL-10, although the mechanisms involved remain to be determined...
  63. ncbi Localization and expression of the aquaporin-1 water channel in mesangial cells in the human glomerulus
    Junichi Kamiie
    Department of Structural Pathology, Institute of Nephrology, Faculty of Medicine, Niigata University, Japan
    Arch Histol Cytol 65:83-90. 2002
    ..No immunoreactivity for AQP1 was demonstrated in rat glomeruli. This study showed the distinct localization of AQP1 in the mesangial cells of human glomeruli, suggesting its role in water movement through these cells...
  64. ncbi Mild heat shock induces autophagic growth arrest, but not apoptosis in U251-MG and U87-MG human malignant glioma cells
    Tadashi Komata
    Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan
    J Neurooncol 68:101-11. 2004
    ..Inhibition of autophagy with bafilomycin A1 may increase the anti-tumor efficacy of mild heat shock against some malignant glioma cells...
  65. ncbi Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease
    Kenju Hara
    Niigata University, Niigata, Japan
    N Engl J Med 360:1729-39. 2009
    ....