T Yamakura

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. ncbi request reprint Anesthetics and ion channels: molecular models and sites of action
    T Yamakura
    Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, Texas 78712, USA
    Annu Rev Pharmacol Toxicol 41:23-51. 2001
  2. ncbi request reprint Sensitivity of the N-methyl-D-aspartate receptor channel to butyrophenones is dependent on the epsilon2 subunit
    T Yamakura
    Department of Anesthesiology, Niigata University School of Medicine, Asahimachi, Japan
    Neuropharmacology 37:709-17. 1998
  3. ncbi request reprint The NR3B subunit does not alter the anesthetic sensitivities of recombinant N-methyl-D-aspartate receptors
    Tomohiro Yamakura
    Division of Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
    Anesth Analg 100:1687-92. 2005
  4. ncbi request reprint Direct inhibition of the N-methyl-D-aspartate receptor channel by high concentrations of opioids
    T Yamakura
    Department of Anesthesiology, Niigata University School of Medicine, Japan
    Anesthesiology 91:1053-63. 1999
  5. ncbi request reprint N-methyl-D-aspartate receptor channel block by meperidine is dependent on extracellular pH
    T Yamakura
    Department of Anesthesiology, Niigata University School of Medicine Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    Anesth Analg 90:928-32. 2000
  6. ncbi request reprint The stereoselective effects of ketamine isomers on heteromeric N-methyl-D-aspartate receptor channels
    T Yamakura
    Department of Anesthesiology, Niigata University School of Medicine, Japan
    Anesth Analg 91:225-9. 2000
  7. ncbi request reprint Thiopental inhibits increases in [Ca2+]i induced by membrane depolarization, NMDA receptor activation, and ischemia in rat hippocampal and cortical slices
    R Z Zhan
    Department of Anesthesiology, Niigata University School of Medicine, Japan
    Anesthesiology 89:456-66. 1998
  8. ncbi request reprint Differential effects of general anesthetics on G protein-coupled inwardly rectifying and other potassium channels
    T Yamakura
    Institute for Cellular and Molecular Biology, University of Texas, Austin 78712-1095, USA
    Anesthesiology 95:144-53. 2001
  9. ncbi request reprint Different sensitivities of NMDA receptor channel subtypes to non-competitive antagonists
    T Yamakura
    Department of Neuropharmacology, Niigata University, Japan
    Neuroreport 4:687-90. 1993
  10. ncbi request reprint Differential inhibitory effects of thiopental, thiamylal and phenobarbital on both voltage-gated calcium channels and NMDA receptors in rat hippocampal slices
    R Z Zhan
    Department of Anaesthesiology, Niigata University School of Medicine, Japan
    Br J Anaesth 81:932-9. 1998

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Anesthetics and ion channels: molecular models and sites of action
    T Yamakura
    Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, Texas 78712, USA
    Annu Rev Pharmacol Toxicol 41:23-51. 2001
    ..In this review, we summarize from a molecular perspective recent advances in our understanding of mechanisms of action of general anesthetics on ligand-gated ion channels...
  2. ncbi request reprint Sensitivity of the N-methyl-D-aspartate receptor channel to butyrophenones is dependent on the epsilon2 subunit
    T Yamakura
    Department of Anesthesiology, Niigata University School of Medicine, Asahimachi, Japan
    Neuropharmacology 37:709-17. 1998
    ..These results, together with previous findings, suggest that the haloperidol block sites of the NMDA receptor channel partially overlap the Mg2+ block sites...
  3. ncbi request reprint The NR3B subunit does not alter the anesthetic sensitivities of recombinant N-methyl-D-aspartate receptors
    Tomohiro Yamakura
    Division of Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
    Anesth Analg 100:1687-92. 2005
    ..Thus, the amino acid residues at the N and N + 1 sites in NR3 subunits are unlikely to be involved in the formation of channel blocking sites in NR1/NR2/NR3 channels...
  4. ncbi request reprint Direct inhibition of the N-methyl-D-aspartate receptor channel by high concentrations of opioids
    T Yamakura
    Department of Anesthesiology, Niigata University School of Medicine, Japan
    Anesthesiology 91:1053-63. 1999
    ..Electrophysiologic and receptor binding studies showed that some opioids have noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist properties...
  5. ncbi request reprint N-methyl-D-aspartate receptor channel block by meperidine is dependent on extracellular pH
    T Yamakura
    Department of Anesthesiology, Niigata University School of Medicine Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    Anesth Analg 90:928-32. 2000
    ..Any antinociceptive and neuroprotective benefit from the N-methyl-D-aspartate-receptor antagonist property of meperidine may be pH dependent...
  6. ncbi request reprint The stereoselective effects of ketamine isomers on heteromeric N-methyl-D-aspartate receptor channels
    T Yamakura
    Department of Anesthesiology, Niigata University School of Medicine, Japan
    Anesth Analg 91:225-9. 2000
    ..9-2.0 microM for epsilon1/zeta1 and epsilon4/zeta1 channels. Thus, the potency ratio of S(+)- and R(-)-ketamine for heteromeric channels was only slightly different among the epsilon/zeta channels...
  7. ncbi request reprint Thiopental inhibits increases in [Ca2+]i induced by membrane depolarization, NMDA receptor activation, and ischemia in rat hippocampal and cortical slices
    R Z Zhan
    Department of Anesthesiology, Niigata University School of Medicine, Japan
    Anesthesiology 89:456-66. 1998
    ..This study examined the effects of thiopental on intracellular calcium ([Ca2+]i) changes induced by membrane depolarization, N-methyl-D-aspartate (NMDA) receptor activation, and ischemia...
  8. ncbi request reprint Differential effects of general anesthetics on G protein-coupled inwardly rectifying and other potassium channels
    T Yamakura
    Institute for Cellular and Molecular Biology, University of Texas, Austin 78712-1095, USA
    Anesthesiology 95:144-53. 2001
    ..This action may be related to some side effects of these agents...
  9. ncbi request reprint Different sensitivities of NMDA receptor channel subtypes to non-competitive antagonists
    T Yamakura
    Department of Neuropharmacology, Niigata University, Japan
    Neuroreport 4:687-90. 1993
    ..These results, together with previous findings, suggest that these non-competitive antagonists as well as (+)MK-801 and Mg2+ act on a common site...
  10. ncbi request reprint Differential inhibitory effects of thiopental, thiamylal and phenobarbital on both voltage-gated calcium channels and NMDA receptors in rat hippocampal slices
    R Z Zhan
    Department of Anaesthesiology, Niigata University School of Medicine, Japan
    Br J Anaesth 81:932-9. 1998
    ..Differential inhibition of both VGCC and NMDA receptors may determine the pharmacological properties of barbiturates and their ability to protect neurones against ischaemia...
  11. ncbi request reprint The effectiveness of preemptive analgesia varies according to the type of surgery: a randomized, double-blind study
    S Aida
    Department of Anesthesiology, Niigata University School of Medicine, Japan
    Anesth Analg 89:711-6. 1999
    ..The rapid retreat of the pain after hemiorrhaphy suggests that central sensitization remits soon after minor surgery, but that in appendicitis, it may be protracted by additional noxious stimuli, such as infection...
  12. ncbi request reprint The Lurcher mutation reveals Ca(2+) permeability and PKC modification of the GluRdelta channels
    K Ikeno
    Department of Cellular Neurobiology, Brain Research Institute, Niigata University, 1-Asahimachi-dori, Niigata 951-8585, Japan
    Neurosci Res 41:193-200. 2001
    ..It indicates the possibility that phosphorylation by PKC activation may inhibit channel with wild-type GluRdelta1 subunit...
  13. ncbi request reprint Sublethal cerebral ischemia inhibits caspase-3 activation induced by subsequent prolonged ischemia in the C57Black/Crj6 strain mouse
    S Qi
    Department of Anesthesiology, Niigata University Graduate School of Medicine, 1 757 Asahimachi, Niigata 951 8510, Japan
    Neurosci Lett 315:133-6. 2001
    ..The present results suggest that the neuroprotection achieved by ischemic preconditioning is related to an attenuation of caspase-3 activation...
  14. ncbi request reprint The role of N-methyl-D-aspartate (NMDA) receptors in pain: a review
    Andrei B Petrenko
    Department of Anesthesiology, Niigata University School of Medicine, Asahimachi 1 757, Niigata 951 8510, Japan
    Anesth Analg 97:1108-16. 2003
    ..Among NMDA receptor subtypes, the NR2B subunit-containing receptors appear particularly important for nociception, thus leading to the possibility that NR2B-selective antagonists may be useful in the treatment of chronic pain...
  15. ncbi request reprint Effects of ketamine on acute somatic nociception in wild-type and N-methyl-D-aspartate (NMDA) receptor epsilon1 subunit knockout mice
    Andrey B Petrenko
    Division of Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1 757, Niigata 951 8510, Japan
    Neuropharmacology 50:741-7. 2006
    ..The results for the mutant mice suggest that the epsilon1 subunit of the NMDA receptor does not mediate the analgesic effects of ketamine in tonic pain...
  16. ncbi request reprint Effect of agmatine on heteromeric N-methyl-D-aspartate receptor channels
    Ahmed R Askalany
    Division of Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
    Neurosci Res 52:387-92. 2005
    ..Thus, regarding the effects on the NMDA receptor channels, agmatine is not like other endogenous polyamines rather it acts as a channel blocker...
  17. ncbi request reprint Reduced sensitivity to ketamine and pentobarbital in mice lacking the N-methyl-D-aspartate receptor GluRepsilon1 subunit
    Andrey B Petrenko
    Department of Anesthesiology, Niigata University School of Medicine, Japan
    Anesth Analg 99:1136-40, table of contents. 2004
    ....
  18. doi request reprint Reduced immobilizing properties of isoflurane and nitrous oxide in mutant mice lacking the N-methyl-D-aspartate receptor GluR(epsilon)1 subunit are caused by the secondary effects of gene knockout
    Andrey B Petrenko
    Division of Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi, Niigata 951 8510, Japan
    Anesth Analg 110:461-5. 2010
    ....
  19. ncbi request reprint The placement of the epidural catheter at the predicted site by electrical stimulation test
    K Hayatsu
    Department of Anesthesiology, School of Medicine, Niigata University, Niigata, Japan
    Anesth Analg 93:1035-9. 2001
    ..We concluded that the electrical stimulation test is effective for verifying the proper placement of the catheter electrode tip...
  20. ncbi request reprint Diagnosis of spinal disease with ultrafine flexible fiberscopes in patients with chronic pain
    Toshiyuki Tobita
    Department of Anesthesiology, Niigata University Graduate School of Medicine, Asahi machi, Niigata 951 8510, Japan
    Spine (Phila Pa 1976) 28:2006-12. 2003
    ..Spinal epidural and subarachnoid spaces were observed with the newly developed fine flexible fiberscopes in 55 patients with chronic pain...
  21. ncbi request reprint Nitrous oxide inhibits glutamatergic transmission in spinal dorsal horn neurons
    Stefan K Georgiev
    Division of Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi, Niigata 951 8510, Japan
    Pain 134:24-31. 2008
    ..Our findings raise the possibility that the antinociceptive effect of N2O may be directly mediated at the level of the spinal cord...
  22. ncbi request reprint Actions of midazolam on excitatory transmission in dorsal horn neurons of adult rat spinal cord
    Tatsuro Kohno
    Division of Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi, Niigata 951 8510, Japan
    Anesthesiology 104:338-43. 2006
    ..Although intrathecal administration of midazolam, a water-soluble imidazobenzodiazepine derivative, has been found to produce analgesia, how it exerts this effect at the neuronal level in the spinal cord is not fully understood...
  23. ncbi request reprint The effects of anesthetics and ethanol on alpha2 adrenoceptor subtypes expressed with G protein-coupled inwardly rectifying potassium channels in Xenopus oocytes
    Koji Hara
    Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicine, 1 1, Iseigaoka, Yahatanishiku, Kitakyushu, 807 8555, Japan
    Anesth Analg 101:1381-8. 2005
    ..Although none of the drugs examined had any effect on the alpha2-ARs, the physiological actions of the alpha2-ARs mediated by the GIRK1/GIRK2 channels may be affected by ethanol and halothane...
  24. ncbi request reprint Propofol enhances GABA(A) receptor-mediated presynaptic inhibition in human spinal cord
    Miyako Shimizu
    Department of Anesthesiology, Niigata University School of Medicine 1 757, Asahi machi, Niigata 951 8510, Japan
    Neuroreport 13:357-60. 2002
    ..v.) significantly augmented the P2 component of seg SCEPs evoked by ulner nerve stimulation. We conclude that propofol enhances GABAA receptor-mediated presynaptic inhibition at primary afferent terminals in human spinal cord...
  25. ncbi request reprint Unaltered pain-related behavior in mice lacking NMDA receptor GluRepsilon 1 subunit
    Andrei B Petrenko
    Department of Cellular Neurobiology, Brain Research Institute, Niigata University, 1 Asahimachi dori, Japan
    Neurosci Res 46:199-204. 2003
    ..Although the contribution of other nociceptive pathways cannot be ruled out, we speculate that the preserved function of GluRepsilon 2-containing NMDARs could explain unaltered nociceptive behavior in mutant mice...
  26. ncbi request reprint The effects of isoflurane on conditioned inhibition by dorsal column stimulation
    Toshiyuki Tobita
    Division of Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Anesth Analg 97:436-41, table of contents. 2003
    ..Further, the results indicate that conditioned inhibition by DC stimulation of PAD receives a facilitatory influence from the supraspinal structures, whereas that of the synchronized activity of the dorsal horn neurons does not...
  27. ncbi request reprint [Elucidation of anesthetic and analgesic effects of ketamine using NMDA receptor epsilon 1 subunit-deficient mice]
    Tomohiro Yamakura
    Masui 55:S141-4. 2006
  28. ncbi request reprint Volatile anesthetic antagonism by long-chain free fatty acids
    Tomohiro Yamakura
    J Anesth 18:71-2. 2004