Research Topics
Species | Ken ichi WatanabeSummaryAffiliation: Niigata University of Pharmacy and Applied Life Sciences Country: Japan Publications
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Detail Information
Publications
Hypertrophic cardiomyopathy with type I CD36 deficiencyK Watanabe
Clinical Pharmacology, Niigata College of Pharmacy, Japan
Jpn Circ J 62:541-2. 1998..These results suggest that type I CD36 deficiency is closely related to hereditary HCM and lack of myocardial LCFA accumulation...- Swimming stress in DN 14-3-3 mice triggers maladaptive cardiac remodeling: role of p38 MAPKKen ichi Watanabe
Dept of Clinical Pharmacology, Niigata Univ of Pharmacy and Applied Life Sciences, Higashijima, Niigata City, Japan
Am J Physiol Heart Circ Physiol 292:H1269-77. 2007..These results indicate for the first time that 14-3-3 protein along with p38 MAPK plays a crucial role in left ventricular remodeling associated with swimming stress... - Comparative effects of quinapril with enalapril in rats with heart failureKenichi Watanabe
Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
Pharmacology 71:157-61. 2004..These results suggest that quinapril may confer greater protection than enalapril against injury from the renin-angiotensin system in heart failure... - Comparative effects of perindopril with enalapril in rats with dilated cardiomyopathyKenichi Watanabe
Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
J Cardiovasc Pharmacol 42:S105-9. 2003.... - Contribution of sympathetic nervous system activity during administration of carvedilol in rats with dilated cardiomyopathyKenichi Watanabe
Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
J Cardiovasc Pharmacol 42:S93-7. 2003..Therefore, high-dose carvedilol treatment should be used with caution to avoid worsening heart failure... - Betaxolol improves the survival rate and changes natriuretic peptide expression in rats with heart failureKenichi Watanabe
Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
J Cardiovasc Pharmacol 41:S99-103. 2003..These observations suggest that betaxolol may improve the survival rate by reducing sudden death and changing the atrial natriuretic peptide and brain natriuretic peptide mRNA expression in patients with heart failure... - Comparative effects of angiotensin II receptor blockade (candesartan) with angiotensin-converting enzyme inhibitor (quinapril) in rats with dilated cardiomyopathyKenichi Watanabe
Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
J Cardiovasc Pharmacol 41:S93-7. 2003.... - Myocardial sympathetic denervation, fatty acid metabolism, and left ventricular wall motion in vasospastic anginaKenichi Watanabe
Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Japan
J Nucl Med 43:1476-81. 2002.... 
Low dose carvedilol inhibits progression of heart failure in rats with dilated cardiomyopathyK Watanabe
Department of Clinical Pharmacology, Niigata College of Pharmacy, Kamisin ei cho, Niigata 950 2081, Japan
Br J Pharmacol 130:1489-95. 2000..05). The area of myocardial fibrosis in Group-C2 was smaller than that in Group-V (12+/-1 and 31+/-2%, P<0.01). These results indicate that a low dose of carvedilol has beneficial effects on dilated cardiomyopathy...- Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicityK Watanabe
Department of Clinical Pharmacology, Niigata College of Pharmacy, Niigata, Niigata 950 2081, Japan
J Biol Chem 275:22293-9. 2000..Furthermore, altered expression of fatty acid-metabolizing proteins seems to lead to myocardial damage and fibrosis, as inflammation and abnormal cell growth control can cause these conditions... - Abnormal fatty acid metabolism in patients with coronary vasospasmK Watanabe
Department of Clinical Pharmacology, Niigata College of Pharmacy, Japan
Ann Nucl Med 13:33-41. 1999..BMIPP scintigraphy is a highly accurate and non-invasive technique for determining the presence and location of vasospasm... - Acute effects of endothelin-1 and TAK-044 (ET(A) and ET(B) receptor antagonist) in rats with dilated cardiomyopathyK Watanabe
Department of Clinical Pharmacology, Niigata College of Pharmacy, Niigata City, Japan
J Cardiovasc Pharmacol 36:S49-54. 2000..These results indicate that the heart may be a major ET-1-producing organ, and a higher dose of ET-1 antagonist is needed to block the effect of ET-1 in rats with dilated cardiomyopathy... - Protection against autoimmune myocarditis by gene transfer of interleukin-10 by electroporationK Watanabe
Department of Clinical Pharmacology, Niigata College of Pharmacy, Japan
Circulation 104:1098-100. 2001..Interleukin (IL)-10 has a variety of immunomodulatory properties. Among the nonviral techniques for gene transfer in vivo, the direct injection of plasmid DNA into muscle is simple, inexpensive, and safe... - Bisoprolol improves survival in rats with heart failureK Watanabe
Department of Clinical Pharmacology, Niigata College of Pharmacy, Japan
J Cardiovasc Pharmacol 38:S55-8. 2001..These observations suggested that bisoprolol may improve survival independently of its effect on left ventricular function by reducing sudden death in patients with severe heart failure... - Myocardial CD36 expression and fatty acid accumulation in patients with type I and II CD36 deficiencyK Watanabe
Department of Clinical Pharmacology, Niigata College of Pharmacy, Japan
Ann Nucl Med 12:261-6. 1998..Because CD36 was not expressed in the myocardial capillary endothelial cells in patients with type I CD36 deficiency, type I CD36 deficiency is closely related to lack of myocardial LCFA accumulation and metabolism in the myocardium... - [F-18]Fluorodeoxyglucose positron emission tomography can predict pathological tumor stage and proliferative activity determined by Ki-67 in clinical stage IA lung adenocarcinomasKen-ichi Watanabe
Department of Thoracic Surgery, Saiseikai Central Hospital, Tokyo, Japan
Jpn J Clin Oncol 36:403-9. 2006..For c-stage IA lung adenocarcinomas showing CR > or = 0.55, mediastinoscopy or neoadjuvant chemotherapy is indicated... - UFD2a mediates the proteasomal turnover of p73 without promoting p73 ubiquitinationMitsuchika Hosoda
Division of Biochemistry, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuoh ku, Chiba 260 8717, Japan
Oncogene 24:7156-69. 2005.... - Functional implication of p73 protein stability in neuronal cell survival and deathToshinori Ozaki
Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan
Cancer Lett 228:29-35. 2005..In this review, we discuss about the cellular proteins implicated in the stability control of p73... - Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1Miki Nishio
Department of Pathology and Immunology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
Nat Cell Biol 9:36-44. 2007..By directing where PtdIns(3,4,5)P(3) accumulates, SHIP1 governs the formation of the leading edge and polarization required for chemotaxis... - Heart rate dynamics during and after exercise in postoperative congenital heart disease patients. Their relation to cardiac autonomic nervous activity and intrinsic sinus node dysfunctionHideo Ohuchi
Department of Pediatrics, National Cardiovascular Center, Osaka, Japan
Am Heart J 154:165-71. 2007..However, the precise mechanisms underlying the abnormal HR dynamics remain unclear... - Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 functionKen ichi Watanabe
Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba 260 8717, Japan
J Biol Chem 277:15113-23. 2002..Expression of MM1 strongly reduced the c-Myc-mediated inhibitory activity on p73 alpha. These results suggest that MM1 may act as a molecular partner for p73 to prevent the c-Myc-mediated inhibitory effect on its activity... - Germ cell-specific expression of microphthalmia-associated transcription factor mRNA in mouse testisHideo Saito
Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575
J Biochem (Tokyo) 134:143-50. 2003..Notably, Mitf mRNA is undetectable in somatic Leydig cells and peritubular cells. Therefore, multiple promoters may direct differential expression of the Mitf gene in the testis and contribute to functional diversity of Mitf isoforms... - Identification of the p33(ING1)-regulated genes that include cyclin B1 and proto-oncogene DEK by using cDNA microarray in a mouse mammary epithelial cell line NMuMGMasato Takahashi
Division of Biochemistry, Chiba Cancer Center Research Institute, Chuoh ku, Chiba 260 8717, Japan
Cancer Res 62:2203-9. 2002.... - Identification of a distal enhancer for the melanocyte-specific promoter of the MITF geneKen ichi Watanabe
Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
Pigment Cell Res 15:201-11. 2002..Thus, SOX10 regulates transcription from the M promoter in a developmental stage-specific manner... - Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signalingKen ichi Yasumoto
Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
EMBO J 21:2703-14. 2002..This study therefore suggests that the MITF/TFE3 family is a new class of nuclear modulators for LEF-1, which may ensure efficient propagation of Wnt signals in many types of cells... - p73-dependent expression of DAN during cisplatin-induced cell death and osteoblast differentiationJun Shinbo
Division of Biochemistry, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuoh ku, Chiba 260 8717, Japan
Biochem Biophys Res Commun 295:501-7. 2002..Our results suggest that there exists a functional association between DAN and p73 during osteoblast differentiation as well as cisplatin-induced cell death... - Improved synthesis of pure [18F]fluoro-compounds for PET studies from bromo-compoundsToshihiro Takahashi
Radioisotope Center, Niigata University, Asahimachi dori 1 757, Niigata 951 8510, Japan
Appl Radiat Isot 58:557-66. 2003..Direct tosylation with silver tosylate was effected in 65-85% yield for most commercial bromo-compounds, and with potassium phthalimide, the bromo-compounds in cold run were converted easily into phthalimide-compounds in 84-90% yield... - Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRBToshinori Ozaki
Division of Biochemistry, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuoh ku, Chiba 260 8717, Japan
Oncogene 22:3231-42. 2003..Taken together, our observations suggest that pRB diminishes the RACK1-mediated inhibition of p73alpha activity through the interaction with RACK1... - Negative autoregulation of p73 and p53 by DeltaNp73 in regulating differentiation and survival of human neuroblastoma cellsTakahito Nakagawa
Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan
Cancer Lett 197:105-9. 2003..Thus, our results suggest that the negative feedback regulation of TAp73 by its target DeltaNp73 is a novel autoregulatory system for modulating cell survival and death, that is also functioning in neuroblastoma cells... - A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activityKou Miyazaki
Division of Biochemistry, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuoh ku, 260 8717, Japan
Biochem Biophys Res Commun 308:106-13. 2003..Consistent with the NEDL2-mediated stabilization of p73, NEDL2 enhanced the p73-dependent transcriptional activation. Thus, our results suggest that NEDL2 activates the function of p73 by increasing its stability... - Regulation of FcgammaR-stimulated phagocytosis by the 72-kDa inositol polyphosphate 5-phosphatase: SHIP1, but not the 72-kDa 5-phosphatase, regulates complement receptor 3 mediated phagocytosis by differential recruitment of these 5-phosphatases to the phKristy A Horan
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
Blood 110:4480-91. 2007..Therefore, 72-5ptase and SHIP1 exhibit specificity in regulating FcgammaR- versus CR3-stimulated phagocytosis by controlling the amplitude and duration of PtdIns(3,4,5)P(3) at the phagocytic cup...