Ken ichi Watanabe

Summary

Affiliation: Niigata University of Pharmacy and Applied Life Sciences
Country: Japan

Publications

  1. ncbi request reprint Hypertrophic cardiomyopathy with type I CD36 deficiency
    K Watanabe
    Clinical Pharmacology, Niigata College of Pharmacy, Japan
    Jpn Circ J 62:541-2. 1998
  2. ncbi request reprint Swimming stress in DN 14-3-3 mice triggers maladaptive cardiac remodeling: role of p38 MAPK
    Ken ichi Watanabe
    Dept of Clinical Pharmacology, Niigata Univ of Pharmacy and Applied Life Sciences, Higashijima, Niigata City, Japan
    Am J Physiol Heart Circ Physiol 292:H1269-77. 2007
  3. ncbi request reprint Comparative effects of quinapril with enalapril in rats with heart failure
    Kenichi Watanabe
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    Pharmacology 71:157-61. 2004
  4. ncbi request reprint Comparative effects of perindopril with enalapril in rats with dilated cardiomyopathy
    Kenichi Watanabe
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    J Cardiovasc Pharmacol 42:S105-9. 2003
  5. ncbi request reprint Contribution of sympathetic nervous system activity during administration of carvedilol in rats with dilated cardiomyopathy
    Kenichi Watanabe
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    J Cardiovasc Pharmacol 42:S93-7. 2003
  6. ncbi request reprint Betaxolol improves the survival rate and changes natriuretic peptide expression in rats with heart failure
    Kenichi Watanabe
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    J Cardiovasc Pharmacol 41:S99-103. 2003
  7. ncbi request reprint Comparative effects of angiotensin II receptor blockade (candesartan) with angiotensin-converting enzyme inhibitor (quinapril) in rats with dilated cardiomyopathy
    Kenichi Watanabe
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    J Cardiovasc Pharmacol 41:S93-7. 2003
  8. ncbi request reprint Myocardial sympathetic denervation, fatty acid metabolism, and left ventricular wall motion in vasospastic angina
    Kenichi Watanabe
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Japan
    J Nucl Med 43:1476-81. 2002
  9. pmc Low dose carvedilol inhibits progression of heart failure in rats with dilated cardiomyopathy
    K Watanabe
    Department of Clinical Pharmacology, Niigata College of Pharmacy, Kamisin ei cho, Niigata 950 2081, Japan
    Br J Pharmacol 130:1489-95. 2000
  10. ncbi request reprint Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity
    K Watanabe
    Department of Clinical Pharmacology, Niigata College of Pharmacy, Niigata, Niigata 950 2081, Japan
    J Biol Chem 275:22293-9. 2000

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Hypertrophic cardiomyopathy with type I CD36 deficiency
    K Watanabe
    Clinical Pharmacology, Niigata College of Pharmacy, Japan
    Jpn Circ J 62:541-2. 1998
    ..These results suggest that type I CD36 deficiency is closely related to hereditary HCM and lack of myocardial LCFA accumulation...
  2. ncbi request reprint Swimming stress in DN 14-3-3 mice triggers maladaptive cardiac remodeling: role of p38 MAPK
    Ken ichi Watanabe
    Dept of Clinical Pharmacology, Niigata Univ of Pharmacy and Applied Life Sciences, Higashijima, Niigata City, Japan
    Am J Physiol Heart Circ Physiol 292:H1269-77. 2007
    ..These results indicate for the first time that 14-3-3 protein along with p38 MAPK plays a crucial role in left ventricular remodeling associated with swimming stress...
  3. ncbi request reprint Comparative effects of quinapril with enalapril in rats with heart failure
    Kenichi Watanabe
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    Pharmacology 71:157-61. 2004
    ..These results suggest that quinapril may confer greater protection than enalapril against injury from the renin-angiotensin system in heart failure...
  4. ncbi request reprint Comparative effects of perindopril with enalapril in rats with dilated cardiomyopathy
    Kenichi Watanabe
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    J Cardiovasc Pharmacol 42:S105-9. 2003
    ....
  5. ncbi request reprint Contribution of sympathetic nervous system activity during administration of carvedilol in rats with dilated cardiomyopathy
    Kenichi Watanabe
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    J Cardiovasc Pharmacol 42:S93-7. 2003
    ..Therefore, high-dose carvedilol treatment should be used with caution to avoid worsening heart failure...
  6. ncbi request reprint Betaxolol improves the survival rate and changes natriuretic peptide expression in rats with heart failure
    Kenichi Watanabe
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    J Cardiovasc Pharmacol 41:S99-103. 2003
    ..These observations suggest that betaxolol may improve the survival rate by reducing sudden death and changing the atrial natriuretic peptide and brain natriuretic peptide mRNA expression in patients with heart failure...
  7. ncbi request reprint Comparative effects of angiotensin II receptor blockade (candesartan) with angiotensin-converting enzyme inhibitor (quinapril) in rats with dilated cardiomyopathy
    Kenichi Watanabe
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    J Cardiovasc Pharmacol 41:S93-7. 2003
    ....
  8. ncbi request reprint Myocardial sympathetic denervation, fatty acid metabolism, and left ventricular wall motion in vasospastic angina
    Kenichi Watanabe
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Japan
    J Nucl Med 43:1476-81. 2002
    ....
  9. pmc Low dose carvedilol inhibits progression of heart failure in rats with dilated cardiomyopathy
    K Watanabe
    Department of Clinical Pharmacology, Niigata College of Pharmacy, Kamisin ei cho, Niigata 950 2081, Japan
    Br J Pharmacol 130:1489-95. 2000
    ..05). The area of myocardial fibrosis in Group-C2 was smaller than that in Group-V (12+/-1 and 31+/-2%, P<0.01). These results indicate that a low dose of carvedilol has beneficial effects on dilated cardiomyopathy...
  10. ncbi request reprint Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity
    K Watanabe
    Department of Clinical Pharmacology, Niigata College of Pharmacy, Niigata, Niigata 950 2081, Japan
    J Biol Chem 275:22293-9. 2000
    ..Furthermore, altered expression of fatty acid-metabolizing proteins seems to lead to myocardial damage and fibrosis, as inflammation and abnormal cell growth control can cause these conditions...
  11. ncbi request reprint Abnormal fatty acid metabolism in patients with coronary vasospasm
    K Watanabe
    Department of Clinical Pharmacology, Niigata College of Pharmacy, Japan
    Ann Nucl Med 13:33-41. 1999
    ..BMIPP scintigraphy is a highly accurate and non-invasive technique for determining the presence and location of vasospasm...
  12. ncbi request reprint Acute effects of endothelin-1 and TAK-044 (ET(A) and ET(B) receptor antagonist) in rats with dilated cardiomyopathy
    K Watanabe
    Department of Clinical Pharmacology, Niigata College of Pharmacy, Niigata City, Japan
    J Cardiovasc Pharmacol 36:S49-54. 2000
    ..These results indicate that the heart may be a major ET-1-producing organ, and a higher dose of ET-1 antagonist is needed to block the effect of ET-1 in rats with dilated cardiomyopathy...
  13. ncbi request reprint Protection against autoimmune myocarditis by gene transfer of interleukin-10 by electroporation
    K Watanabe
    Department of Clinical Pharmacology, Niigata College of Pharmacy, Japan
    Circulation 104:1098-100. 2001
    ..Interleukin (IL)-10 has a variety of immunomodulatory properties. Among the nonviral techniques for gene transfer in vivo, the direct injection of plasmid DNA into muscle is simple, inexpensive, and safe...
  14. ncbi request reprint Bisoprolol improves survival in rats with heart failure
    K Watanabe
    Department of Clinical Pharmacology, Niigata College of Pharmacy, Japan
    J Cardiovasc Pharmacol 38:S55-8. 2001
    ..These observations suggested that bisoprolol may improve survival independently of its effect on left ventricular function by reducing sudden death in patients with severe heart failure...
  15. ncbi request reprint Myocardial CD36 expression and fatty acid accumulation in patients with type I and II CD36 deficiency
    K Watanabe
    Department of Clinical Pharmacology, Niigata College of Pharmacy, Japan
    Ann Nucl Med 12:261-6. 1998
    ..Because CD36 was not expressed in the myocardial capillary endothelial cells in patients with type I CD36 deficiency, type I CD36 deficiency is closely related to lack of myocardial LCFA accumulation and metabolism in the myocardium...
  16. ncbi request reprint [F-18]Fluorodeoxyglucose positron emission tomography can predict pathological tumor stage and proliferative activity determined by Ki-67 in clinical stage IA lung adenocarcinomas
    Ken ichi Watanabe
    Department of Thoracic Surgery, Saiseikai Central Hospital, Tokyo, Japan
    Jpn J Clin Oncol 36:403-9. 2006
    ....
  17. ncbi request reprint UFD2a mediates the proteasomal turnover of p73 without promoting p73 ubiquitination
    Mitsuchika Hosoda
    Division of Biochemistry, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuoh ku, Chiba 260 8717, Japan
    Oncogene 24:7156-69. 2005
    ....
  18. ncbi request reprint Functional implication of p73 protein stability in neuronal cell survival and death
    Toshinori Ozaki
    Division of Biochemistry, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuoh ku, Chiba 260 8717, Japan
    Cancer Lett 228:29-35. 2005
    ..In this review, we discuss about the cellular proteins implicated in the stability control of p73...
  19. ncbi request reprint Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1
    Miki Nishio
    Department of Pathology and Immunology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Nat Cell Biol 9:36-44. 2007
    ..By directing where PtdIns(3,4,5)P(3) accumulates, SHIP1 governs the formation of the leading edge and polarization required for chemotaxis...
  20. ncbi request reprint Heart rate dynamics during and after exercise in postoperative congenital heart disease patients. Their relation to cardiac autonomic nervous activity and intrinsic sinus node dysfunction
    Hideo Ohuchi
    Department of Pediatrics, National Cardiovascular Center, Osaka, Japan
    Am Heart J 154:165-71. 2007
    ..However, the precise mechanisms underlying the abnormal HR dynamics remain unclear...
  21. ncbi request reprint Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function
    Ken ichi Watanabe
    Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba 260 8717, Japan
    J Biol Chem 277:15113-23. 2002
    ..Expression of MM1 strongly reduced the c-Myc-mediated inhibitory activity on p73 alpha. These results suggest that MM1 may act as a molecular partner for p73 to prevent the c-Myc-mediated inhibitory effect on its activity...
  22. ncbi request reprint Germ cell-specific expression of microphthalmia-associated transcription factor mRNA in mouse testis
    Hideo Saito
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575
    J Biochem 134:143-50. 2003
    ..Notably, Mitf mRNA is undetectable in somatic Leydig cells and peritubular cells. Therefore, multiple promoters may direct differential expression of the Mitf gene in the testis and contribute to functional diversity of Mitf isoforms...
  23. ncbi request reprint Identification of the p33(ING1)-regulated genes that include cyclin B1 and proto-oncogene DEK by using cDNA microarray in a mouse mammary epithelial cell line NMuMG
    Masato Takahashi
    Division of Biochemistry, Chiba Cancer Center Research Institute, Chuoh ku, Chiba 260 8717, Japan
    Cancer Res 62:2203-9. 2002
    ....
  24. ncbi request reprint Identification of a distal enhancer for the melanocyte-specific promoter of the MITF gene
    Ken ichi Watanabe
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Pigment Cell Res 15:201-11. 2002
    ..Thus, SOX10 regulates transcription from the M promoter in a developmental stage-specific manner...
  25. pmc Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling
    Ken ichi Yasumoto
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi 980 8575, Japan
    EMBO J 21:2703-14. 2002
    ..This study therefore suggests that the MITF/TFE3 family is a new class of nuclear modulators for LEF-1, which may ensure efficient propagation of Wnt signals in many types of cells...
  26. ncbi request reprint p73-dependent expression of DAN during cisplatin-induced cell death and osteoblast differentiation
    Jun Shinbo
    Division of Biochemistry, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuoh ku, Chiba 260 8717, Japan
    Biochem Biophys Res Commun 295:501-7. 2002
    ..Our results suggest that there exists a functional association between DAN and p73 during osteoblast differentiation as well as cisplatin-induced cell death...
  27. ncbi request reprint Improved synthesis of pure [18F]fluoro-compounds for PET studies from bromo-compounds
    Toshihiro Takahashi
    Radioisotope Center, Niigata University, Asahimachi dori 1 757, Niigata 951 8510, Japan
    Appl Radiat Isot 58:557-66. 2003
    ..Direct tosylation with silver tosylate was effected in 65-85% yield for most commercial bromo-compounds, and with potassium phthalimide, the bromo-compounds in cold run were converted easily into phthalimide-compounds in 84-90% yield...
  28. ncbi request reprint Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB
    Toshinori Ozaki
    Division of Biochemistry, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuoh ku, Chiba 260 8717, Japan
    Oncogene 22:3231-42. 2003
    ..Taken together, our observations suggest that pRB diminishes the RACK1-mediated inhibition of p73alpha activity through the interaction with RACK1...
  29. ncbi request reprint Negative autoregulation of p73 and p53 by DeltaNp73 in regulating differentiation and survival of human neuroblastoma cells
    Takahito Nakagawa
    Division of Biochemistry, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuoh ku, Chiba 260 8717, Japan
    Cancer Lett 197:105-9. 2003
    ..Thus, our results suggest that the negative feedback regulation of TAp73 by its target DeltaNp73 is a novel autoregulatory system for modulating cell survival and death, that is also functioning in neuroblastoma cells...
  30. ncbi request reprint A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity
    Kou Miyazaki
    Division of Biochemistry, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuoh ku, 260 8717, Japan
    Biochem Biophys Res Commun 308:106-13. 2003
    ..Consistent with the NEDL2-mediated stabilization of p73, NEDL2 enhanced the p73-dependent transcriptional activation. Thus, our results suggest that NEDL2 activates the function of p73 by increasing its stability...
  31. ncbi request reprint Regulation of FcgammaR-stimulated phagocytosis by the 72-kDa inositol polyphosphate 5-phosphatase: SHIP1, but not the 72-kDa 5-phosphatase, regulates complement receptor 3 mediated phagocytosis by differential recruitment of these 5-phosphatases to the ph
    Kristy A Horan
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
    Blood 110:4480-91. 2007
    ..Therefore, 72-5ptase and SHIP1 exhibit specificity in regulating FcgammaR- versus CR3-stimulated phagocytosis by controlling the amplitude and duration of PtdIns(3,4,5)P(3) at the phagocytic cup...