Toshifumi Wakai

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. ncbi request reprint Surgical outcomes of minor hepatectomy for locally advanced gallbladder carcinoma
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hepatogastroenterology 59:2083-8. 2012
  2. doi request reprint Early DNA damage response in residual carcinoma in situ at ductal stumps and local recurrence in patients undergoing resection for extrahepatic cholangiocarcinoma
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata, 951 8510, Japan
    J Hepatobiliary Pancreat Sci 20:362-9. 2013
  3. ncbi request reprint Clinicopathological features of benign biliary strictures masquerading as biliary malignancy
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Am Surg 78:1388-91. 2012
  4. pmc Histologic evaluation of intrahepatic micrometastases in patients treated with or without neoadjuvant chemotherapy for colorectal carcinoma liver metastasis
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Int J Clin Exp Pathol 5:308-14. 2012
  5. doi request reprint Ribonucleotide reductase M1 expression in intrahepatic cholangiocarcinoma
    Toshifumi Wakai
    Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hepatogastroenterology 58:1659-63. 2011
  6. pmc Prognostic significance of NQO1 expression in intrahepatic cholangiocarcinoma
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences Niigata, Japan
    Int J Clin Exp Pathol 4:363-70. 2011
  7. doi request reprint Appraisal of 1 cm hepatectomy margins for intrahepatic micrometastases in patients with colorectal carcinoma liver metastasis
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata City, 951 8510, Japan
    Ann Surg Oncol 15:2472-81. 2008
  8. doi request reprint Surgical outcomes for hepatocellular carcinoma in nonalcoholic fatty liver disease
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, 951 8510, Japan
    J Gastrointest Surg 15:1450-8. 2011
  9. ncbi request reprint Hepatic lymph node dissection provides a survival benefit for patients with nodal disease of colorectal carcinoma liver metastases
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata City 951 8510, Japan
    Hepatogastroenterology 56:186-90. 2009
  10. doi request reprint Alteration of p53-binding protein 1 expression as a risk factor for local recurrence in patients undergoing resection for extrahepatic cholangiocarcinoma
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
    Int J Oncol 38:1227-36. 2011

Collaborators

Detail Information

Publications71

  1. ncbi request reprint Surgical outcomes of minor hepatectomy for locally advanced gallbladder carcinoma
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hepatogastroenterology 59:2083-8. 2012
    ..This study aimed to evaluate whether wedge resection or S4bS5 resection was the more beneficial hepatectomy procedure for patients with locally advanced gallbladder carcinoma...
  2. doi request reprint Early DNA damage response in residual carcinoma in situ at ductal stumps and local recurrence in patients undergoing resection for extrahepatic cholangiocarcinoma
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata, 951 8510, Japan
    J Hepatobiliary Pancreat Sci 20:362-9. 2013
    ....
  3. ncbi request reprint Clinicopathological features of benign biliary strictures masquerading as biliary malignancy
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Am Surg 78:1388-91. 2012
    ..Although benign biliary strictures are rare, differentiating benign strictures from malignancy remains problematic. Thus, the treatment approach for biliary strictures should remain surgical resection for presumed biliary malignancy...
  4. pmc Histologic evaluation of intrahepatic micrometastases in patients treated with or without neoadjuvant chemotherapy for colorectal carcinoma liver metastasis
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Int J Clin Exp Pathol 5:308-14. 2012
    ..313 and p=0.526, respectively). In conclusion, NAC reduces the incidence of intrahepatic micrometastases in patients with CRLM, but NAC has no significant effect on their distribution when intrahepatic micrometastases are present...
  5. doi request reprint Ribonucleotide reductase M1 expression in intrahepatic cholangiocarcinoma
    Toshifumi Wakai
    Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hepatogastroenterology 58:1659-63. 2011
    ....
  6. pmc Prognostic significance of NQO1 expression in intrahepatic cholangiocarcinoma
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences Niigata, Japan
    Int J Clin Exp Pathol 4:363-70. 2011
    ..001) and loss of NQO1 expression (p<0.001) had an independent adverse effect on survival. Loss of NQO1 expression reflects dedifferentiation and thus indicates a poor prognosis for patients undergoing resection for ICC...
  7. doi request reprint Appraisal of 1 cm hepatectomy margins for intrahepatic micrometastases in patients with colorectal carcinoma liver metastasis
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata City, 951 8510, Japan
    Ann Surg Oncol 15:2472-81. 2008
    ..This study sought to clarify the distribution of intrahepatic micrometastases and elucidate an adequate hepatectomy margin for colorectal carcinoma liver metastases...
  8. doi request reprint Surgical outcomes for hepatocellular carcinoma in nonalcoholic fatty liver disease
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, 951 8510, Japan
    J Gastrointest Surg 15:1450-8. 2011
    ..The present study investigated outcomes following surgical resection of hepatocellular carcinoma (HCC) in nonalcoholic fatty liver disease (NAFLD)...
  9. ncbi request reprint Hepatic lymph node dissection provides a survival benefit for patients with nodal disease of colorectal carcinoma liver metastases
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata City 951 8510, Japan
    Hepatogastroenterology 56:186-90. 2009
    ..This retrospective study aimed to define the role of hepatic lymph node dissection in the surgical management of patients with resectable colorectal carcinoma liver metastases...
  10. doi request reprint Alteration of p53-binding protein 1 expression as a risk factor for local recurrence in patients undergoing resection for extrahepatic cholangiocarcinoma
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
    Int J Oncol 38:1227-36. 2011
    ..0% at 5 years; P=0.020). In conclusion, after resection for extrahepatic cholangiocarcinoma, clinically evident local recurrence at ductal stumps is closely associated with 53BP1 inactivation and decreased apoptosis...
  11. doi request reprint Mode of hepatic spread from gallbladder carcinoma: an immunohistochemical analysis of 42 hepatectomized specimens
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Am J Surg Pathol 34:65-74. 2010
    ..The mode of hepatic spread independently predicts long-term survival after resection for patients with gallbladder carcinoma. Hepatic metastatic nodules indicate a dismal outcome after resection...
  12. doi request reprint Assessment of the nodal status in ampullary carcinoma: the number of positive lymph nodes versus the lymph node ratio
    Jun Sakata
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata City, 951 8510, Japan
    World J Surg 35:2118-24. 2011
    ..This study was intended to compare the prognostic power of the number of positive lymph nodes with that of the lymph node ratio in patients with ampullary carcinoma...
  13. doi request reprint Fucosylated fraction of alpha-fetoprotein as a predictor of prognosis in patients with hepatocellular carcinoma after curative treatment
    Yasushi Tamura
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata, Japan
    Dig Dis Sci 55:2095-101. 2010
    ..The aim of this study was to evaluate the clinical usefulness of measuring the Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3) for prognostic predictor in patients with hepatocellular carcinoma (HCC)...
  14. pmc Assessment of lymph node status in gallbladder cancer: location, number, or ratio of positive nodes
    Yoshio Shirai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City 951 8510, Japan
    World J Surg Oncol 10:87. 2012
    ..The aim of this study was to compare the anatomical location of positive nodes, number of positive nodes, and lymph node ratio (LNR) as prognostic predictors in gallbladder cancer...
  15. pmc Risk of subsequent biliary malignancy in patients undergoing cyst excision for congenital choledochal cysts
    Taku Ohashi
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Gastroenterol Hepatol 28:243-7. 2013
    ..The aim of this study was to elucidate the risk of subsequent biliary malignancy in patients undergoing cyst excision for congenital choledochal cysts...
  16. doi request reprint Overexpression of osteopontin independently correlates with vascular invasion and poor prognosis in patients with hepatocellular carcinoma
    Pavel V Korita
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951 8510, Japan
    Hum Pathol 39:1777-83. 2008
    ..These results suggest that overexpression of osteopontin independently correlates with vascular invasion and thus predicts poor survival for patients with HCC, whereas aberrant expression of E-cadherin or beta-catenin does not...
  17. ncbi request reprint Intrahepatic lymphatic invasion independently predicts poor survival and recurrences after hepatectomy in patients with colorectal carcinoma liver metastases
    Pavel V Korita
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata City, 951 8510, Japan
    Ann Surg Oncol 14:3472-80. 2007
    ..We hypothesized that intrahepatic lymphatic invasion reflects the nodal status of colorectal carcinoma liver metastases and may function as an adverse prognostic factor...
  18. ncbi request reprint Clinical significance of lymph node micrometastasis in ampullary carcinoma
    Eiko Sakata
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City 951 8510, Japan
    World J Surg 30:985-91. 2006
    ..This study aimed to clarify the clinical significance of lymph node micrometastasis in ampullary carcinoma...
  19. doi request reprint Reduced NKG2D ligand expression in hepatocellular carcinoma correlates with early recurrence
    Hiroteru Kamimura
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Hepatol 56:381-8. 2012
    ....
  20. doi request reprint Loss of carcinoembryonic antigen-related cell adhesion molecule 1 expression predicts metachronous pulmonary metastasis and poor survival in patients with hepatoblastoma
    Mami Tsukada
    Division of Pediatric Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951 8510, Japan
    J Pediatr Surg 44:1522-8. 2009
    ..The aim of this study was to test the hypothesis that loss of CEACAM1 expression in hepatoblastoma cells may promote hematogeneous metastasis and function as an adverse prognostic factor...
  21. ncbi request reprint Loss of liver-intestine cadherin in human intrahepatic cholangiocarcinoma promotes angiogenesis by up-regulating metal-responsive transcription factor-1 and placental growth factor
    Masaaki Takamura
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachi dori 1, Chuo Ku, Niigata 951 8510, Japan
    Int J Oncol 36:245-54. 2010
    ..Loss of LI-cadherin results in up-regulation of MTF-1 and PlGF, thereby regulating angiogenesis in ICC...
  22. ncbi request reprint Clinical significance of intracapsular and extratumoral venous invasion in hepatocellular carcinoma
    Masanori Ohashi
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata City 951 8510, Japan
    Hepatogastroenterology 57:611-5. 2010
    ..The current study sought to clarify whether intracapsular venous invasion and extratumoral venous invasion confer different prognostic significance in patients undergoing hepatectomy for hepatocellular carcinoma...
  23. ncbi request reprint Multidrug resistance-associated protein 2 determines the efficacy of cisplatin in patients with hepatocellular carcinoma
    Pavel V Korita
    Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
    Oncol Rep 23:965-72. 2010
    ..Expression of MRP2 determines the efficacy of cisplatin-based chemotherapy in patients with HCC...
  24. doi request reprint Preoperative cholangitis independently increases in-hospital mortality after combined major hepatic and bile duct resection for hilar cholangiocarcinoma
    Jun Sakata
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata, Japan
    Langenbecks Arch Surg 394:1065-72. 2009
    ..This study evaluated the impact of ductal bile bacteria (bactibilia or cholangitis) on the development of surgical site infection (SSI) or in-hospital mortality after resection for hilar cholangiocarcinoma...
  25. doi request reprint Blockade of ataxia telangiectasia mutated sensitizes hepatoma cell lines to sorafenib by interfering with Akt signaling
    Shun Fujimaki
    Department of Medical Technology, Niigata University Graduate School of Health Sciences, Niigata, Japan
    Cancer Lett 319:98-108. 2012
    ..Moreover, ATM inhibition effectively suppressed the sorafenib-induced cell migration. Taken together, manipulation of ATM activity might be a useful strategy for improving sorafenib treatment of HCC...
  26. doi request reprint Liver-intestine cadherin in intraepithelial neoplasia of intrahepatic cholangiocarcinoma
    Makoto Inoue
    Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hepatogastroenterology 58:2045-51. 2011
    ..The aim of this study was to identify factors associated with LI-cadherin expression in biliary intraepithelial lesions of intrahepatic cholangiocarcinoma (ICC)...
  27. doi request reprint Depth of invasion determines the postresectional prognosis for patients with T1 extrahepatic cholangiocarcinoma
    Masayuki Nagahashi
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951 8510, Japan
    Cancer 116:400-5. 2010
    ....
  28. ncbi request reprint Anatomic resection independently improves long-term survival in patients with T1-T2 hepatocellular carcinoma
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City 951 8510, Japan
    Ann Surg Oncol 14:1356-65. 2007
    ..This study aimed to evaluate the effect of anatomic resection on long-term outcomes in patients with pathologic T1-T2 (pT1-T2) hepatocellular carcinoma...
  29. ncbi request reprint Catheter tract implantation metastases associated with percutaneous biliary drainage for extrahepatic cholangiocarcinoma
    Jun Sakata
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City 951 8510, Japan
    World J Gastroenterol 11:7024-7. 2005
    ....
  30. ncbi request reprint Major hepatic resection reduces the probability of intrahepatic recurrences following resection of colorectal carcinoma liver metastases
    Shigenori Nagakura
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City, 951 8510 Japan
    Hepatogastroenterology 50:779-83. 2003
    ..The use of major versus limited hepatic resection for colorectal carcinoma liver metastases remains controversial. We evaluated the role of major hepatic resection in managing patients with colorectal carcinoma liver metastases...
  31. ncbi request reprint Depth of subserosal invasion predicts long-term survival after resection in patients with T2 gallbladder carcinoma
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Ann Surg Oncol 10:447-54. 2003
    ..This study aimed to identify a subgroup of patients with inapparent T2 gallbladder carcinoma who may be best suited for radical second resection...
  32. ncbi request reprint Impact of ductal resection margin status on long-term survival in patients undergoing resection for extrahepatic cholangiocarcinoma
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Cancer 103:1210-6. 2005
    ....
  33. ncbi request reprint Perimuscular connective tissue contains more and larger lymphatic vessels than the shallower layers in human gallbladders
    Masayuki Nagahashi
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City, Japan
    World J Gastroenterol 13:4480-3. 2007
    ..To clarify whether perimuscular connective tissue contains more lymphatic vessels than the shallower layers in human gallbladders...
  34. doi request reprint Histological evaluation of intracapsular venous invasion for discrimination between portal and hepatic venous invasion in hepatocellular carcinoma
    Masanori Ohashi
    Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Gastroenterol Hepatol 25:143-9. 2010
    ..Histological criteria for intracapsular venous invasion (IVI) that would allow its discrimination between portal and hepatic venous invasion in hepatocellular carcinoma (HCC) have not been established...
  35. ncbi request reprint Long-term outcomes of hepatectomy vs percutaneous ablation for treatment of hepatocellular carcinoma < or =4 cm
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    World J Gastroenterol 12:546-52. 2006
    ..To determine which treatment modality--hepatectomy or percutaneous ablation--is more beneficial for patients with small hepatocellular carcinoma (HCC) (< or =4 cm) in terms of long-term outcomes...
  36. doi request reprint P21-activated kinase-2 is a critical mediator of transforming growth factor-β-induced hepatoma cell migration
    Munehiro Sato
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Japan
    J Gastroenterol Hepatol 28:1047-55. 2013
    ..With the aim of investigating the diagnostic and treatment modalities for patients with hepatocellular carcinoma (HCC), the signaling pathway that may contribute to TGF-β-mediated cell invasion in hepatoma cells was evaluated...
  37. doi request reprint Combined major hepatectomy and pancreaticoduodenectomy for locally advanced biliary carcinoma: long-term results
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
    World J Surg 32:1067-74. 2008
    ..This study aimed to define the role of combined major hepatectomy and pancreaticoduodenectomy in the surgical management of biliary carcinoma and to identify potential candidates for this aggressive procedure...
  38. ncbi request reprint Intraepithelial ductal spread in colorectal carcinoma liver metastasis
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata, Japan
    Hepatogastroenterology 58:583-8. 2011
    ..This study aimed to evaluate the usefulness of immunohistochemical combinations for discrimination between intraepithelial ductal spread of colorectal carcinoma liver metastasis (CRLM) and that of intrahepatic cholangiocarcinoma (ICC)...
  39. pmc Regional lymphadenectomy for gallbladder cancer: rational extent, technical details, and patient outcomes
    Yoshio Shirai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951 8510, Japan
    World J Gastroenterol 18:2775-83. 2012
    ..To define the rational extent of regional lymphadenectomy for gallbladder cancer and to clarify its effect on long-term survival...
  40. doi request reprint Interstitial pneumonia arising in a patient treated with oxaliplatin, 5-fluorouracil, and, leucovorin (FOLFOX)
    Katsuki Muneoka
    Department of Surgery, Niitsu Medical Center Hospital, Niigata, Japan
    Int J Clin Oncol 14:457-9. 2009
    ..Once interstitial pneumonia has occurred, cessation of the regimen is mandatory, and high-dose corticosteroid treatment is commonly given to rescue patients from this potentially lethal complication...
  41. ncbi request reprint Aberrant expression of vimentin correlates with dedifferentiation and poor prognosis in patients with intrahepatic cholangiocarcinoma
    Pavel V Korita
    Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
    Anticancer Res 30:2279-85. 2010
    ..This study aimed to elucidate the prognostic value of vimentin expression in patients with intrahepatic cholangiocarcinoma (ICC)...
  42. ncbi request reprint Low preoperative platelet counts predict a high mortality after partial hepatectomy in patients with hepatocellular carcinoma
    Kazuhiro Kaneko
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Japan
    World J Gastroenterol 11:5888-92. 2005
    ....
  43. ncbi request reprint Clinical and diagnostic significance of preoperative computed tomography findings of ascites in patients with advanced gastric cancer
    Kazuhito Yajima
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Japan
    Am J Surg 192:185-90. 2006
    ..The relationship between ascites, as detected by preoperative computed tomography (CT), and peritoneal metastasis of gastric cancer requires clarification because of its likely significance for clinical outcome...
  44. doi request reprint Number of positive lymph nodes independently determines the prognosis after resection in patients with gallbladder carcinoma
    Jun Sakata
    Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Ann Surg Oncol 17:1831-40. 2010
    ..This study was designed to compare the prognostic power of the location of positive lymph nodes with that of the number of positive lymph nodes in gallbladder carcinoma...
  45. doi request reprint Clinical significance of cell cycle inhibitors in hepatocellular carcinoma
    Yasunobu Matsuda
    Department of Medical Technology, Niigata University Graduate School of Health Sciences, 2 746 Asahimachi dori, Niigata, 951 8518, Japan
    Med Mol Morphol 46:185-92. 2013
    ..Taking into consideration the complex interaction between p16 and p27, a comprehensive analysis including p16 and p27 would be useful for predicting the prognosis of HCC patients. ..
  46. ncbi request reprint Intraoperative assessment of the resectability of hilar cholangiocarcinoma
    Yoshio Shirai
    Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Hepatogastroenterology 59:2436-8. 2012
    ..In conclusion, this simple technique, isolation of the right hepatic artery behind Calot's triangle before starting resection, should be applied to all hilar malignancies when a left-sided hepatectomy is planned...
  47. ncbi request reprint Jaundice at presentation heralds advanced disease and poor prognosis in patients with ampullary carcinoma
    Naoyuki Yokoyama
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi dori 1 757, Niigata, 951 8510, Japan
    World J Surg 29:519-23. 2005
    ..0014). In conclusion, jaundice at presentation predicts advanced-stage ampullary carcinoma and a poor prognosis. Pancreatic invasion and superior mesenteric nodal involvement were not observed in nonjaundiced patients...
  48. ncbi request reprint Adenosquamous carcinoma of the gallbladder warrants resection only if curative resection is feasible
    Yasuhiro Oohashi
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Cancer 94:3000-5. 2002
    ..The objective of this study was to clarify the effectiveness of resection for patients with adenosquamous/squamous cell carcinoma of the gallbladder...
  49. ncbi request reprint Tumor suppressor carcinoembryonic antigen-related cell adhesion molecule 1 potentates the anchorage-independent growth of human hepatoma HepG2 cells
    Mariko Hokari
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi dori 1 757, Niigata 951 8510, Japan
    Life Sci 81:336-45. 2007
    ....
  50. doi request reprint Hepatitis B virus X induces cell proliferation in the hepatocarcinogenesis via up-regulation of cytoplasmic p21 expression
    Masahiko Yano
    Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences Niigata University, Niigata, Japan
    Liver Int 33:1218-29. 2013
    ..The effects of HBx on the expression and function of p21 also remain controversial...
  51. doi request reprint Alteration of the DNA damage response in colorectal tumor progression
    Hiroaki Takabayashi
    Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
    Hum Pathol 44:1038-46. 2013
    ....
  52. doi request reprint Progression of hypermethylation of the p16(INK4A) gene from normal liver to nontumorous liver and hepatocellular carcinoma: an evaluation using quantitative PCR analysis
    So Kurita
    Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences of Niigata University, 1 754, Asahimachi Dori, Niigata City, 951 8122, Japan
    Dig Dis Sci 54:80-8. 2009
    ..There may be a greater proportion of cells which contain methylated p16 in nontumorous than in normal liver. However, the difference was so small that the functional relevance to hepatocarcinogenesis remains elusive...
  53. pmc "Extended" radical cholecystectomy for gallbladder cancer: long-term outcomes, indications and limitations
    Yoshio Shirai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951 8510, Japan
    World J Gastroenterol 18:4736-43. 2012
    ..To delineate indications and limitations for "extended" radical cholecystectomy for gallbladder cancer: a procedure which was instituted in our department in 1982...
  54. ncbi request reprint An 11-year survivor who underwent ten sequential resections of colonic adenocarcinoma metastases
    Shigenori Nagakura
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City, 951 8510 Japan
    Hepatogastroenterology 50:1032-3. 2003
    ..Surgeons should pursue resection for colorectal carcinoma metastases, regardless of frequent operations and sites involved, as reliable medical treatment remains unestablished...
  55. doi request reprint Full-thickness cholecystectomy with limited lymphadenectomy for gallbladder cancer
    Yoshio Shirai
    Niigata University, Niigata City, Japan
    Hepatogastroenterology 59:1338-40. 2012
    ..This less invasive procedure can be applied to patients with advanced age and/or comorbid disease(s), provided that the tumor is apparently confined to the gallbladder wall and has no gross evidence of distant metastases/nodal disease...
  56. doi request reprint Morphological features of early gallbladder carcinoma
    Toshifumi Wakai
    Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hepatogastroenterology 59:1013-7. 2012
    ..This study aimed to clarify the morphological features of early gallbladder carcinoma including tumors invading the lamina propria (pT1a) or muscular layer (pT1b)...
  57. ncbi request reprint Radical lymph node dissection for gallbladder cancer: indications and limitations
    Yoshio Shirai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City, 951 8510 Japan
    Surg Oncol Clin N Am 16:221-32. 2007
    ..Extended resection with extensive lymphadenectomy should be limited to expert surgeons because it may cause serious morbidity and mortality...
  58. pmc Multicentric occurrence of hepatocellular carcinoma with nonalcoholic steatohepatitis
    Hirokazu Kawai
    Hirokazu Kawai, Department of Clinical Laboratory, Niigata University Medical and Dental Hospital, Niigata 951 8510, Japan
    World J Hepatol 3:15-23. 2011
    ..To reveal the manner of hepatocellular carcinoma (HCC) development in patients with nonalcoholic steatohepatitis (NASH) focusing on multicentric occurrence (MO) of HCC...
  59. ncbi request reprint Squamous cell carcinoma-antigen messenger RNA level in peripheral blood predicts recurrence after resection in patients with esophageal squamous cell carcinoma
    Hideyuki Honma
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Japan
    Surgery 139:678-85. 2006
    ....
  60. ncbi request reprint Humoral hypercalcemia complicating adenocarcinoma of the sigmoid colon: report of a case
    Jun Sakata
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Surg Today 35:692-5. 2005
    ....
  61. ncbi request reprint 5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine
    Katsuki Muneoka
    Department of Surgery, Niitsu Medical Center Hospital, Niigata, Japan
    Int J Clin Oncol 10:441-3. 2005
    ..The experience of this case, together with a review of the literature, suggests that FBAL is related to 5-FU-induced cardiotoxicity. S-1 may be administered safely to patients with 5-FU-induced cardiotoxicity...
  62. ncbi request reprint Aberrant expression of pRb and p16(INK4), alone or in combination, indicates poor outcome after resection in patients with colorectal carcinoma
    Xing Cui
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Hum Pathol 35:1189-95. 2004
    ..994, P <0.0001, respectively). Most CRCs demonstrate aberrant expression of pRb and/or p16 at resectable stages. Aberrant expression of pRb and p16, alone and in combination, heralds poor prognosis in patients with CRC...
  63. ncbi request reprint Loss of carcinoembryonic antigen-related cell adhesion molecule 1 expression is an adverse prognostic factor in hepatocellular carcinoma
    Pauldion V Cruz
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Cancer 104:354-60. 2005
    ..The authors hypothesized that loss of CEACAM1 expression in hepatocellular carcinoma (HCC) cells may function as an adverse prognostic factor...
  64. ncbi request reprint Narrow portion of the terminal choledochus is a cause of upstream biliary dilatation in patients with anomalous union of the pancreatic and biliary ducts
    Tatsuya Nomura
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 Asahimachi dori, Niigata, 951 8510, Japan
    World J Gastroenterol 11:6503-7. 2005
    ..To clarify the pathogenesis of biliary dilatation associated with anomalous union of the pancreatic and biliary ducts (AUPBD)...
  65. ncbi request reprint Radical second resection provides survival benefit for patients with T2 gallbladder carcinoma first discovered after laparoscopic cholecystectomy
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City, 951 8510, Japan
    World J Surg 26:867-71. 2002
    ..Radical second resection may be beneficial for patients with pT2 gallbladder carcinoma first discovered after laparoscopic cholecystectomy...
  66. pmc Genetic changes of p53, K-ras, and microsatellite instability in gallbladder carcinoma in high-incidence areas of Japan and Hungary
    Masayuki Nagahashi
    Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
    World J Gastroenterol 14:70-5. 2008
    ..To disclose geographic differences in genetic changes involved in gallbladder carcinogenesis between two distinct high-incidence areas of Japan and Hungary...
  67. ncbi request reprint Increased risk of cholelithiasis after esophagectomy
    Kazuhiko Tsunoda
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, 951 8510, Niigata, Japan
    J Hepatobiliary Pancreat Surg 11:319-23. 2004
    ..This study was intended to test this hypothesis and to elucidate factors influencing the incidence of cholelithiasis after esophagectomy...
  68. ncbi request reprint Hemangiopericytoma arising in the greater omentum: report of a case
    Kazuhiro Kaneko
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Surg Today 33:722-4. 2003
    ..A review of the reported cases suggests that surgical resection provides the only chance of cure and that a high mitotic index (>4/10 high-power fields) and a tumor size of > or =20 cm predict an unfavorable prognosis after resection...
  69. ncbi request reprint Peroral cholangioscopy for non-invasive papillary cholangiocarcinoma with extensive superficial ductal spread
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, Niigata 951 8510, Japan
    World J Gastroenterol 11:6554-6. 2005
    ....
  70. ncbi request reprint Possible role of human cytomegalovirus in pouchitis after proctocolectomy with ileal pouch-anal anastomosis in patients with ulcerative colitis
    Damian Casadesus
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City 951 8510, Japan
    World J Gastroenterol 13:1085-9. 2007
    ..To detect the presence of human cytomegalovirus (HCMV) proteins and genes on the ileal pouch of patients with ulcerative colitis who have undergone proctocolectomy with ileal pouch-anal anastomosis (IPAA)...
  71. ncbi request reprint Alcohol consumption as a risk factor for esophageal adenocarcinoma in North China
    Jun Chen
    Division of Information Science and Biostatistics, Niigata University Graduate School of Medical and Dental Sciences, Niigara, Japan
    Tohoku J Exp Med 224:21-7. 2011
    ..In conclusion, heavy alcohol consumption increases the risk for esophageal adenocarcinoma independent of the duration of such consumption...