Research Topics

Genomes and Genes


Shuji Terai


Affiliation: Niigata University
Country: Japan


  1. Kawata Y, Tsuchiya A, Seino S, Watanabe Y, Kojima Y, Ikarashi S, et al. Early injection of human adipose tissue-derived mesenchymal stem cell after inflammation ameliorates dextran sulfate sodium-induced colitis in mice through the induction of M2 macrophages and regulatory T cells. Cell Tissue Res. 2019;: pubmed publisher
    ..Timing of injection is critical for the effective therapeutic effects of hAdMSCs. Furthermore, part of the associated mechanism includes T cell activation and expansion and altered macrophage polarization. ..
  2. Kamimura K, Yokoo T, Terai S. Gene Therapy for Pancreatic Diseases: Current Status. Int J Mol Sci. 2018;19: pubmed publisher
    ..We aim to identify new areas for improvement of the current methodologies and new strategies that will lead to safe and effective gene therapeutic approaches in pancreatic diseases. ..
  3. Kamimura H, Setsu T, Kimura N, Yokoo T, Sakamaki A, Kamimura K, et al. Renal Impairment in Chronic Hepatitis B: A Review. Diseases. 2018;6: pubmed publisher
    ..Hence, we should take into account the stage of impaired renal function in patients with cirrhosis. The aims of this article are to review the epidemiology, clinical presentation, treatment, and prevention of HBV-associated nephropathy. ..
  4. Kamimura K, Yokoo T, Abe H, Kobayashi Y, Ogawa K, Shinagawa Y, et al. Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions. Pharmaceutics. 2015;7:213-23 pubmed publisher
    ..This review summarizes the current status and recent progress in the development of hydrodynamics-based gene delivery and discusses the future directions for its clinical application. ..
  5. Yokoo T, Kanefuji T, Suda T, Kamimura K, Liu D, Terai S. Site-Specific Impact of a Regional Hydrodynamic Injection: Computed Tomography Study during Hydrodynamic Injection Targeting the Swine Liver. Pharmaceutics. 2015;7:334-43 pubmed publisher
    ..A further investigation that simultaneously evaluates gene delivery efficiency and hemodynamics using CT is needed to establish feasible parameters for a regional HGD in large animals. ..
  6. Terai S, Tsuchiya A. Status of and candidates for cell therapy in liver cirrhosis: overcoming the "point of no return" in advanced liver cirrhosis. J Gastroenterol. 2017;52:129-140 pubmed publisher
    ..In this review, we summarize the status and future prospects of cell therapy for liver cirrhosis. ..
  7. Shinagawa Kobayashi Y, Kamimura K, Goto R, Ogawa K, Inoue R, Yokoo T, et al. Effect of histidine on sorafenib-induced vascular damage: Analysis using novel medaka fish model. Biochem Biophys Res Commun. 2018;496:556-561 pubmed publisher
    ..And our results suggest that SFN causes vascular damage by narrowing peripheral vessel diameter, and that histidine effectively counteracts these changes to maintain blood flow. ..
  8. Fujisawa K, Terai S, Takami T, Yamamoto N, Yamasaki T, Matsumoto T, et al. Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4. J Exp Clin Cancer Res. 2016;35:48 pubmed publisher
    ..These findings provide a new potential target for efficient anticancer therapies by controlling AK4 expression. ..
  9. Kamimura K, Suda T, Yokoo T, Kamimura H, Kanefuji T, Tsuchiya A, et al. Transhepatic arterial infusion chemotherapy using a combination of miriplatin and CDDP powder versus miriplatin alone in the treatment of hepatocellular carcinoma: a randomized controlled trial. BMC Cancer. 2017;17:322 pubmed publisher
    ..This study was registered on 1 January 2012 with the University Hospital Medical Information Network Clinical Trials Registry ( , UMIN000004691). ..