Affiliation: Niigata University
Hoshi O, Sugizaki A, Cho Y, Takei N. BDNF Reduces eEF2 Phosphorylation and Enhances Novel Protein Synthesis in the Growth Cones of Dorsal Root Ganglia Neurons. Neurochem Res. 2018;43:1242-1249 pubmed publisher
..These results indicated that BDNF rapidly activates translation and enhances novel protein synthesis in growth cones of DRG though the mTOR signaling. ..
Furukawa K, Fuse I, Iwakura Y, Sotoyama H, Hanyu O, Nawa H, et al
. Advanced glycation end products induce brain-derived neurotrophic factor release from human platelets through the Src-family kinase activation. Cardiovasc Diabetol. 2017;16:20 pubmed publisher
..Chronic elevation of AGEs may induce depletion or downregulation of BDNF in platelets during the progression of DM. ..
Takei N, Inamura N, Kawamura M, Namba H, Hara K, Yonezawa K, et al
. Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites. J Neurosci. 2004;24:9760-9 pubmed
..Taken together, these data indicate that mTOR-dependent translation activation is essential for the upregulation of local protein synthesis in neuronal dendrites. ..
Takei N, Kawamura M, Ishizuka Y, Kakiya N, Inamura N, Namba H, et al
. Brain-derived neurotrophic factor enhances the basal rate of protein synthesis by increasing active eukaryotic elongation factor 2 levels and promoting translation elongation in cortical neurons. J Biol Chem. 2009;284:26340-8 pubmed publisher
..Taken together, our results demonstrate that the increased level of active eEF2 induced by chronic BDNF stimulation enhances translational elongation processes and increases the total rate of protein synthesis in neurons...