Nobuyuki Takei

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. ncbi request reprint BDNF and NT-3 but not CNTF counteract the Ca2+ ionophore-induced apoptosis of cultured cortical neurons: involvement of dual pathways
    N Takei
    Department of Applied Biology, Kyoto Institute of Technology, Sakyo, Japan
    Neuropharmacology 38:283-8. 1999
  2. pmc Brain-derived neurotrophic factor enhances the basal rate of protein synthesis by increasing active eukaryotic elongation factor 2 levels and promoting translation elongation in cortical neurons
    Nobuyuki Takei
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    J Biol Chem 284:26340-8. 2009
  3. ncbi request reprint Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites
    Nobuyuki Takei
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    J Neurosci 24:9760-9. 2004
  4. ncbi request reprint [Critical roles of translational control on higher brain function]
    Nobuyuki Takei
    Tanpakushitsu Kakusan Koso 51:2617-23. 2006
  5. ncbi request reprint Brain-derived neurotrophic factor enhances neuronal translation by activating multiple initiation processes: comparison with the effects of insulin
    N Takei
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi 1, Niigata 951 8585, Japan
    J Biol Chem 276:42818-25. 2001
  6. doi request reprint Dopamine-dependent ectodomain shedding and release of epidermal growth factor in developing striatum: target-derived neurotrophic signaling (Part 2)
    Yuriko Iwakura
    Molecular Neurobiology, Brain Research Institute, Niigata University, Japan
    J Neurochem 118:57-68. 2011
  7. ncbi request reprint Enhancement of translation elongation in neurons by brain-derived neurotrophic factor: implications for mammalian target of rapamycin signaling
    Naoko Inamura
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    J Neurochem 95:1438-45. 2005
  8. pmc Transforming growth factor alpha attenuates the functional expression of AMPA receptors in cortical GABAergic neurons
    Hisaaki Namba
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata 951 8585, Japan
    Mol Cell Neurosci 31:628-41. 2006
  9. ncbi request reprint In vivo administration of epidermal growth factor and its homologue attenuates developmental maturation of functional excitatory synapses in cortical GABAergic neurons
    Tadasato Nagano
    Molecular Neurobiology, Brain Research Institute, Niigata University, 951 8585 Japan
    Eur J Neurosci 25:380-90. 2007
  10. ncbi request reprint Quantitative analyses of mRNA and protein levels of neurotrophin-3 in the rat retina during postnatal development and aging
    Masaaki Seki
    Division of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951 8585, Japan
    Jpn J Ophthalmol 48:460-4. 2004

Collaborators

Detail Information

Publications37

  1. ncbi request reprint BDNF and NT-3 but not CNTF counteract the Ca2+ ionophore-induced apoptosis of cultured cortical neurons: involvement of dual pathways
    N Takei
    Department of Applied Biology, Kyoto Institute of Technology, Sakyo, Japan
    Neuropharmacology 38:283-8. 1999
    ..These results suggest that the neuroprotective effect of BDNF requires activation of both phosphatidylinositol-3 kinase and the Ras/MAP kinase cascade and that CNTF signaling through other pathways is without an effect in this system...
  2. pmc Brain-derived neurotrophic factor enhances the basal rate of protein synthesis by increasing active eukaryotic elongation factor 2 levels and promoting translation elongation in cortical neurons
    Nobuyuki Takei
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    J Biol Chem 284:26340-8. 2009
    ..Taken together, our results demonstrate that the increased level of active eEF2 induced by chronic BDNF stimulation enhances translational elongation processes and increases the total rate of protein synthesis in neurons...
  3. ncbi request reprint Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites
    Nobuyuki Takei
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    J Neurosci 24:9760-9. 2004
    ..Taken together, these data indicate that mTOR-dependent translation activation is essential for the upregulation of local protein synthesis in neuronal dendrites...
  4. ncbi request reprint [Critical roles of translational control on higher brain function]
    Nobuyuki Takei
    Tanpakushitsu Kakusan Koso 51:2617-23. 2006
  5. ncbi request reprint Brain-derived neurotrophic factor enhances neuronal translation by activating multiple initiation processes: comparison with the effects of insulin
    N Takei
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi 1, Niigata 951 8585, Japan
    J Biol Chem 276:42818-25. 2001
    ..These results suggest strongly that BDNF simultaneously activates multiple signaling cascades consisting of phosphatidylinositol 3-kinase, mammalian TOR, and MAPK to enhance translation initiation in neurons...
  6. doi request reprint Dopamine-dependent ectodomain shedding and release of epidermal growth factor in developing striatum: target-derived neurotrophic signaling (Part 2)
    Yuriko Iwakura
    Molecular Neurobiology, Brain Research Institute, Niigata University, Japan
    J Neurochem 118:57-68. 2011
    ..Therefore, the activation of striatal dopamine receptors induces shedding and release of EGF to provide a retrograde neurotrophic signal to midbrain dopaminergic neurons...
  7. ncbi request reprint Enhancement of translation elongation in neurons by brain-derived neurotrophic factor: implications for mammalian target of rapamycin signaling
    Naoko Inamura
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    J Neurochem 95:1438-45. 2005
    ..These results strongly suggest that BDNF enhances translation elongation through the activation of the mTOR-eEF2 pathway...
  8. pmc Transforming growth factor alpha attenuates the functional expression of AMPA receptors in cortical GABAergic neurons
    Hisaaki Namba
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata 951 8585, Japan
    Mol Cell Neurosci 31:628-41. 2006
    ..These observations reveal a negative regulatory activity of the ErbB1 ligand, TGFalpha, which reduces the input sensitivity of cortical GABAergic neurons to attenuate their inhibitory function...
  9. ncbi request reprint In vivo administration of epidermal growth factor and its homologue attenuates developmental maturation of functional excitatory synapses in cortical GABAergic neurons
    Tadasato Nagano
    Molecular Neurobiology, Brain Research Institute, Niigata University, 951 8585 Japan
    Eur J Neurosci 25:380-90. 2007
    ..We conclude that EGF or other ErbB1 ligand(s) attenuates a developmental increase in AMPA receptor expression and function in cortical GABAergic neurons...
  10. ncbi request reprint Quantitative analyses of mRNA and protein levels of neurotrophin-3 in the rat retina during postnatal development and aging
    Masaaki Seki
    Division of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951 8585, Japan
    Jpn J Ophthalmol 48:460-4. 2004
    ..In this study, we sought to elucidate changes in the levels of neurotrophin-3 (NT-3) in the rat retina throughout postnatal development and aging...
  11. doi request reprint Activation of mammalian target of rapamycin signaling in spatial learning
    Sihua Qi
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1, Asahimachi, Niigata 951 8585, Japan
    Neurosci Res 68:88-93. 2010
    ..Thus, mTOR signaling is activated during learning, enhances translation, and plays a crucial role in the spatial learning...
  12. pmc Brain-derived neurotrophic factor signal enhances and maintains the expression of AMPA receptor-associated PDZ proteins in developing cortical neurons
    Hussam Jourdi
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, 951 8585, Japan
    Dev Biol 263:216-30. 2003
    ..This work reveals a novel function of BDNF in postsynaptic development by regulating the PDZ protein expression...
  13. ncbi request reprint BDNF is upregulated by postnatal development and visual experience: quantitative and immunohistochemical analyses of BDNF in the rat retina
    Masaaki Seki
    Department of Molecular Neurobiology, Brain Research Institute, and Division of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Invest Ophthalmol Vis Sci 44:3211-8. 2003
    ..This study sought to elucidate changes in the levels and distribution of brain-derived neurotrophic factor (BDNF) in the retina throughout aging and depending on visual experience...
  14. doi request reprint Qualitative and quantitative re-evaluation of epidermal growth factor-ErbB1 action on developing midbrain dopaminergic neurons in vivo and in vitro: target-derived neurotrophic signaling (Part 1)
    Yuriko Iwakura
    Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    J Neurochem 118:45-56. 2011
    ..Although neurotrophic supports to dopaminergic neurons are redundant, these results confirm that ErbB1 ligands contribute to the phenotypic and functional development of nigral dopaminergic neurons...
  15. ncbi request reprint Differential distributions of peptides in the epidermal growth factor family and phosphorylation of ErbB 1 receptor in adult rat brain
    Ying shan Piao
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi dori 1 757, Niigata 951 8585, Japan
    Neurosci Lett 390:21-4. 2005
    ..These observations suggest that the activation of brain ErbB 1 involves post-translational regulation of multiple EGF family members in a region-specific manner...
  16. ncbi request reprint Müller Cells as a source of brain-derived neurotrophic factor in the retina: noradrenaline upregulates brain-derived neurotrophic factor levels in cultured rat Müller cells
    Masaaki Seki
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi, 951 8585, Nigata, Nigata, Japan
    Neurochem Res 30:1163-70. 2005
    ..These results suggest that Müller cells may act as an endogenous source of BDNF in the retina. Furthermore, induction of BDNF expression by adrenergic agonists may provide a therapeutic approach to retinal neurodegenerative disorders...
  17. ncbi request reprint Activity-dependent shedding of heparin-binding EGF-like growth factor in brain neurons
    Yuji Shishido
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    Biochem Biophys Res Commun 348:963-70. 2006
    ..Therefore, we propose that glutamatergic neurotransmission in the central nervous system plays a crucial role in regulating ectodomain shedding of pro-HB-EGF...
  18. ncbi request reprint Influences of dopaminergic lesion on epidermal growth factor-ErbB signals in Parkinson's disease and its model: neurotrophic implication in nigrostriatal neurons
    Yuriko Iwakura
    Molecular Neurobiology, Brain Research Institute, Niigata University, Japan
    J Neurochem 93:974-83. 2005
    ..These findings suggest that the neurotrophic activity of EGF is maintained by afferent signals of midbrain dopaminergic neurons and is impaired in patients with Parkinson's disease...
  19. ncbi request reprint Involvement of brain-derived neurotrophic factor in early retinal neuropathy of streptozotocin-induced diabetes in rats: therapeutic potential of brain-derived neurotrophic factor for dopaminergic amacrine cells
    Masaaki Seki
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata, Niigata 951 8585, Japan
    Diabetes 53:2412-9. 2004
    ..These findings suggest that the early retinal neuropathy of diabetes involves the reduced expression of BDNF and can be ameliorated by an exogenous supply of this neurotrophin...
  20. doi request reprint Leucine induces phosphorylation and activation of p70S6K in cortical neurons via the system L amino acid transporter
    Yuta Ishizuka
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    J Neurochem 106:934-42. 2008
    ..We propose that leucine plays important roles in regulating signaling by p70S6 kinase by acting as an intercellular communicator in the CNS...
  21. doi request reprint Cyclooxygenase-2 plays a critical role in retinal ganglion cell death after transient ischemia: real-time monitoring of RGC survival using Thy-1-EGFP transgenic mice
    Yasuhiro Sakai
    Division of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, 1, Asahimachi, Niigata 951 8585, Japan
    Neurosci Res 65:319-25. 2009
    ..Our data show that COX-2 plays a crucial role in ischemia-reperfusion injury-induced RGC death. Inhibition of COX-2 activity may therefore be an effective therapy for neurodegenerative diseases of the retina and optic nerve...
  22. ncbi request reprint [Modulation of brain function by neurotrophins]
    Nobuyuki Takei
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951 8585, Japan
    Seikagaku 76:111-23. 2004
  23. doi request reprint In vitro production of an active neurotrophic factor, neuregulin-1: qualitative comparison of different cell-free translation systems
    Ran Wang
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi dori, Niigata 951 8585, Japan
    Neurosci Lett 497:90-3. 2011
    ..These results demonstrate that the reticulocyte lysate translation system produces active neurotrophic factors in vitro and is useful for radiolabeling or preliminary assessment of novel neurotrophic factors and their variants...
  24. ncbi request reprint Neonatal exposure to epidermal growth factor induces dopamine D2-like receptor supersensitivity in adult sensorimotor gating
    Hidekazu Sotoyama
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi dori 1 757, Niigata, 951 8585, Japan
    Psychopharmacology (Berl) 191:783-92. 2007
    ..Thus, rats treated with EGF as neonates are used as a putative animal model for schizophrenia showing impaired prepulse inhibition (PPI) and other cognitive deficits in the adult stage...
  25. doi request reprint AMP-activated protein kinase counteracts brain-derived neurotrophic factor-induced mammalian target of rapamycin complex 1 signaling in neurons
    Yuta Ishizuka
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan Department of Neurobiology and Behavior, Gunma University Graduate School of Medicine, Gunma, Japan
    J Neurochem 127:66-77. 2013
    ..These results indicate that AMPK inhibits the effects of BDNF on mTORC1-mediated translation in neurons...
  26. ncbi request reprint [Local translational control at synapse]
    Nobuyuki Takei
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1, Asahimachi, Niigata 951 8585, Japan
    Seikagaku 78:939-48. 2006
  27. pmc ErbB2 dephosphorylation and anti-proliferative effects of neuregulin-1 in ErbB2-overexpressing cells; re-evaluation of their low-affinity interaction
    Ran Wang
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, 951 8585, Japan
    Sci Rep 3:1402. 2013
    ..These results suggest that the higher concentrations of neuregulin-1 exert an anti-oncogenic activity to attenuate ErbB2 auto-phosphorylation potentially through its low-affinity interaction with ErbB2...
  28. ncbi request reprint Distinct influences of neonatal epidermal growth factor challenge on adult neurobehavioral traits in four mouse strains
    Manavu Tohmi
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi dori 1 757, Niigata, 951 8585, Japan
    Behav Genet 35:615-29. 2005
    ..Genetic components regulating brain ErbB1 signaling strongly influence the direction and strength of behavioral responses stemming from the neonatal neurotrophic perturbation...
  29. ncbi request reprint Cellular and subcellular distributions of translation initiation, elongation and release factors in rat hippocampus
    Naoko Inamura
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi 1, Niigata 951 8585, Japan
    Brain Res Mol Brain Res 111:165-74. 2003
    ..These results suggest that regulated protein synthesis occurs in the hippocampus, with differences existing between different subregions such as CA1, CA3 and dentate gyrus...
  30. ncbi request reprint Developmental changes of eukaryotic initiation factor 2B subunits in rat hippocampus
    Naoko Inamura
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi 1, Niigata Niigata 951 8585, Japan
    Neurosci Lett 346:117-9. 2003
    ..Aged hippocampus contained only trace amounts of these subunits. The finding that eIF2B subunit levels are high in developing hippocampus suggests that regulated protein synthesis is active in young, highly plastic brain...
  31. ncbi request reprint A novel rat orthologue and homologue for the Drosophila crooked neck gene in neural stem cells and their immediate descendants
    Naoki Amada
    Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi dori 1 757, Niigata 951 8585, Japan
    J Biochem 133:615-23. 2003
    ..These findings suggest that both TPR-motif-containing proteins are involved in RNA processing of mammalian neural stem cells and their immediate descendants...
  32. doi request reprint Periventricular nodular heterotopia functionally couples with the overlying hippocampus
    Hiroki Kitaura
    Department of Pathology, Brain Research Institute, University of Niigata, Niigata, Japan
    Epilepsia 53:e127-31. 2012
    ..The coupling response evoked by stimulation of the subiculum and developing within the heterotopic nodule was enhanced by application of bicuculline. Therefore, activities of the hippocampus and the nodule are closely correlated...
  33. ncbi request reprint Establishment of a novel enzyme-linked immunosorbent assay for Thy-1; quantitative assessment of neuronal degeneration
    Masaaki Seki
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi 1, 951 8585 Niigata, Japan
    Neurosci Lett 329:185-8. 2002
    ..We found that injection of a neurotoxin, N-methyl-D-aspartate, into the vitreous cavity reduced the Thy-1 level in the retina. Thy-1 ELISA will be useful for quantitative assessment of neurodegeneration in the CNS...
  34. ncbi request reprint Brain-derived neurotrophic factor regulates surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptors by enhancing the N-ethylmaleimide-sensitive factor/GluR2 interaction in developing neocortical neurons
    Mako Narisawa-Saito
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    J Biol Chem 277:40901-10. 2002
    ..These results reveal a novel role of BDNF in regulating the surface expression of AMPA receptors through a GluR2-NSF interaction...
  35. ncbi request reprint Possible involvement of BDNF release in long-lasting synapse formation induced by repetitive PKA activation
    Naoko Taniguchi
    Department of Neuroscience, Osaka University Graduate School of Frontier Biosciences, Machikaneyama cho 1 1, Toyonaka, Osaka 560 0043, Japan
    Neurosci Lett 406:38-42. 2006
    ..The release of BDNF upon PKA activation was confirmed by phosphorylation of TrkB. These results indicate that the release of BDNF is involved in the putative signaling cascade connecting PKA activation and synapse formation...
  36. ncbi request reprint PACAP and NGF cooperatively enhance choline acetyltransferase activity in postnatal basal forebrain neurons by complementary induction of its different mRNA species
    Aki Yuhara
    Institute for Protein Research, Osaka University, 3 2 Yamadaoka, Suita, 565 0871, Osaka, Japan
    Biochem Biophys Res Commun 301:344-9. 2003
    ..These results explain the cooperative neurotrophic action of NGF and PACAP on postnatal cholinergic neurons...
  37. ncbi request reprint Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity
    Ryota Hashimoto
    Molecular Neurobiology Section, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1363, USA
    Neuropharmacology 43:1173-9. 2002
    ..Taken together, these data suggest that the BDNF/TrkB pathway plays an essential role in mediating the neuroprotective effect of lithium...