Hitoshi Takahashi

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. pmc Corticosteroid therapy in a patient with cerebral amyloid angiopathy-related inflammation
    Akio Kimura
    Department of Neurology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, 501 1194, Japan
    J Neuroinflammation 10:39. 2013
  2. ncbi request reprint Autosomal dominant cerebellar ataxia (SCA6): clinical, genetic and neuropathological study in a family
    H Takahashi
    Department of Pathology, Brain Research Institute, Niigata University, Asahimachi, Japan
    Acta Neuropathol 95:333-7. 1998
  3. ncbi request reprint Lipidized (foamy) tumor cells in a spinal cord ependymoma with collagenous metaplasia
    H Takahashi
    Department of Pathology, Brain Research Institute, Niigata University, Asahimachi, Japan
    Acta Neuropathol 95:421-5. 1998
  4. ncbi request reprint The cellular pathology of Parkinson's disease
    H Takahashi
    Department of Pathology, Brain Research Institute, Niigata University, Japan
    Neuropathology 21:315-22. 2001
  5. ncbi request reprint Controversy: is Parkinson's disease a single disease entity? Yes
    H Takahashi
    Department of Pathology, Brain Research Institute, University of Niigata, Japan
    Parkinsonism Relat Disord 11:S31-7. 2005
  6. ncbi request reprint A 76-year-old woman presenting with adult-onset, slowly progressive cerebellar symptoms
    Hitoshi Takahashi
    Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan
    Neuropathology 22:360-1. 2002
  7. ncbi request reprint Neuronal nuclear alterations in dentatorubral-pallidoluysian atrophy: ultrastructural and morphometric studies of the cerebellar granule cells
    H Takahashi
    Department of Pathology, Brain Research Institute, Niigata University, 1 757 Asahimachi, 951 8585, Niigata, Japan
    Brain Res 919:12-9. 2001
  8. doi request reprint Results of treatment of 112 cases of primary CNS lymphoma
    Ryuya Yamanaka
    Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan
    Jpn J Clin Oncol 38:373-80. 2008
  9. doi request reprint Sporadic amyotrophic lateral sclerosis of long duration is associated with relatively mild TDP-43 pathology
    Yasushi Nishihira
    Department of Pathology, Brain Research Institute, University of Niigata, 1 757 Asahimachi, Chuo Ku, Niigata, 951 8585, Japan
    Acta Neuropathol 117:45-53. 2009
  10. doi request reprint Involvement of Onuf's nucleus in Machado-Joseph disease: a morphometric and immunohistochemical study
    Hiroshi Shimizu
    Department of Pathology, Brain Research Institute, University of Niigata, Chuo Ku, Niigata 951 8585, Japan
    Acta Neuropathol 120:439-48. 2010

Collaborators

Detail Information

Publications125 found, 100 shown here

  1. pmc Corticosteroid therapy in a patient with cerebral amyloid angiopathy-related inflammation
    Akio Kimura
    Department of Neurology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, 501 1194, Japan
    J Neuroinflammation 10:39. 2013
    ..In summary, CAA-ri encephalopathy is a relapsing or progressive disorder and may be treatable by adequate immunosuppressive therapy. The anti-Aβ 42 antibody in CSF is a useful biological marker for therapeutic monitoring of CAA-ri...
  2. ncbi request reprint Autosomal dominant cerebellar ataxia (SCA6): clinical, genetic and neuropathological study in a family
    H Takahashi
    Department of Pathology, Brain Research Institute, Niigata University, Asahimachi, Japan
    Acta Neuropathol 95:333-7. 1998
    ..We conclude that the pathological phenotype of this newly classified autosomal dominant cerebellar ataxia, SCA6, is cerebello-olivary atrophy, or more strictly cerebellar cortical atrophy...
  3. ncbi request reprint Lipidized (foamy) tumor cells in a spinal cord ependymoma with collagenous metaplasia
    H Takahashi
    Department of Pathology, Brain Research Institute, Niigata University, Asahimachi, Japan
    Acta Neuropathol 95:421-5. 1998
    ..Cilia were very rare. We considered the present case to be an unusual, lipidized variant of ependymoma. The collagen nodules appeared to be produced by the tumor cells themselves...
  4. ncbi request reprint The cellular pathology of Parkinson's disease
    H Takahashi
    Department of Pathology, Brain Research Institute, Niigata University, Japan
    Neuropathology 21:315-22. 2001
    ..The role of both alpha-synuclein and synphilin-1 in normal conditions has yet to be clarified...
  5. ncbi request reprint Controversy: is Parkinson's disease a single disease entity? Yes
    H Takahashi
    Department of Pathology, Brain Research Institute, University of Niigata, Japan
    Parkinsonism Relat Disord 11:S31-7. 2005
    ..Extensive pathological findings support the idea that PD is a single disease entity and that there are no cases of PD in which neurodegeneration occurs only in the substantia nigra and in which there are no LBs...
  6. ncbi request reprint A 76-year-old woman presenting with adult-onset, slowly progressive cerebellar symptoms
    Hitoshi Takahashi
    Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan
    Neuropathology 22:360-1. 2002
  7. ncbi request reprint Neuronal nuclear alterations in dentatorubral-pallidoluysian atrophy: ultrastructural and morphometric studies of the cerebellar granule cells
    H Takahashi
    Department of Pathology, Brain Research Institute, Niigata University, 1 757 Asahimachi, 951 8585, Niigata, Japan
    Brain Res 919:12-9. 2001
    ....
  8. doi request reprint Results of treatment of 112 cases of primary CNS lymphoma
    Ryuya Yamanaka
    Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan
    Jpn J Clin Oncol 38:373-80. 2008
    ..Due to the lack of well-conducted randomized trials, the optimal treatment remains controversial. Available retrospective studies are difficult to discuss, however, some common themes can be found...
  9. doi request reprint Sporadic amyotrophic lateral sclerosis of long duration is associated with relatively mild TDP-43 pathology
    Yasushi Nishihira
    Department of Pathology, Brain Research Institute, University of Niigata, 1 757 Asahimachi, Chuo Ku, Niigata, 951 8585, Japan
    Acta Neuropathol 117:45-53. 2009
    ..It is now apparent that SALS of long duration is actually part of a TDP-43 proteinopathy spectrum...
  10. doi request reprint Involvement of Onuf's nucleus in Machado-Joseph disease: a morphometric and immunohistochemical study
    Hiroshi Shimizu
    Department of Pathology, Brain Research Institute, University of Niigata, Chuo Ku, Niigata 951 8585, Japan
    Acta Neuropathol 120:439-48. 2010
    ..In conclusion, the present findings strongly suggest that neuronal loss in ON, the degree of which is highly influenced by the extent of expansion of CAG repeats, is a consistent feature in MJD...
  11. ncbi request reprint Corticobasal degeneration with focal, massive tau accumulation in the subcortical white matter astrocytes
    Kenji Sakai
    Department of Pathology, Brain Research Institute, University of Niigata, 1 757 Asahimachi, Niigata 951 8585, Japan
    Acta Neuropathol 112:341-8. 2006
    ..Finally, in both cases, the pathological diagnosis of CBD was considered to be appropriate. However, the tau pathology affecting the subcortical white matter astrocytes was very unusual for the disease...
  12. doi request reprint Selective occurrence of TDP-43-immunoreactive inclusions in the lower motor neurons in Machado-Joseph disease
    Chun Feng Tan
    Department of Pathology, Brain Research Institute, University of Niigata, 1 757 Asahimachi, Niigata, Japan
    Acta Neuropathol 118:553-60. 2009
    ..However, the immunohistochemical findings strongly suggested that in MJD, in addition to the polyglutamine-dependent disease process, TDP-43-related pathogenesis is associated with degeneration and death of the lower motor neurons...
  13. doi request reprint Sporadic amyotrophic lateral sclerosis: two pathological patterns shown by analysis of distribution of TDP-43-immunoreactive neuronal and glial cytoplasmic inclusions
    Yasushi Nishihira
    Department of Pathology, Brain Research Institute, University of Niigata, 1 757 Asahimachi, Chuo Ku, Niigata, 951 8585, Japan
    Acta Neuropathol 116:169-82. 2008
    ....
  14. doi request reprint Increased expression and activation of cytosolic phospholipase A2 in the spinal cord of patients with sporadic amyotrophic lateral sclerosis
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku 162 8666, Tokyo, Japan
    Acta Neuropathol 119:345-54. 2010
    ....
  15. ncbi request reprint Sporadic four-repeat tauopathy with frontotemporal lobar degeneration, Parkinsonism, and motor neuron disease: a distinct clinicopathological and biochemical disease entity
    Yong juan Fu
    Department of Pathology, Brain Research Institute, University of Niigata, Chuo Ku, Japan
    Acta Neuropathol 120:21-32. 2010
    ..Based on these clinicopathological, biochemical, and genetic findings, we consider that the present three patients form a distinct 4R tauopathy associated with sporadic FTLD...
  16. ncbi request reprint Genetic association of CTNNA3 with late-onset Alzheimer's disease in females
    Akinori Miyashita
    Center for Bioresources, Brain Research Institute, Niigata University, Niigata, Japan
    Hum Mol Genet 16:2854-69. 2007
    ..Furthermore, we found that this SNP exhibited no interaction with the APOE-epsilon4 allele. Our data suggest that CTNNA3 may affect LOAD through a female-specific mechanism independent of the APOE-epsilon4 allele...
  17. doi request reprint SORL1 is genetically associated with neuropathologically characterized late-onset Alzheimer's disease
    Yanan Wen
    Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan
    J Alzheimers Dis 35:387-94. 2013
    ..Case-control haplotype analysis demonstrated that some haplotypes are associated with LOAD in both LD regions. Our replication study strongly supports the preceding evidence that SORL1 is likely one of the genes associated with LOAD...
  18. doi request reprint Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia
    Takeshi Ikeuchi
    Department of Molecular Neuroscience, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951 8585, Japan
    Arch Neurol 65:514-9. 2008
    ..Multiplication of the alpha-synuclein gene (SNCA) (OMIM 163890) has been identified as a causative mutation in hereditary Parkinson disease or dementia with Lewy bodies...
  19. doi request reprint Creutzfeldt-Jakob disease with an M232R substitution: report of a patient showing slowly progressive disease with abundant plaque-like PrP deposits in the cerebellum
    Hiroshi Shimizu
    Department of Pathology, Brain Research Institute, Niigata University, Asahimachi, Chuo Ku, Niigata, Japan
    Neuropathology 29:735-43. 2009
    ....
  20. doi request reprint Japanese amyotrophic lateral sclerosis patients with GGGGCC hexanucleotide repeat expansion in C9ORF72
    Takuya Konno
    Department of Molecular Neuroscience, Brain Research Institute, Niigata University, 1 757 Asahimachi dori, Chuo Ku, Niigata City, Niigata 951 8585, Japan
    J Neurol Neurosurg Psychiatry 84:398-401. 2013
    ..The diseases resulting from this expansion are referred to as 'c9FTD/ALS'. It has been suggested that c9FTD/ALS arose from a single founder. However, the existence of c9FTD/ALS in non-white populations has not been evaluated...
  21. ncbi request reprint Frontotemporal dementia with co-occurrence of astrocytic plaques and tufted astrocytes, and severe degeneration of the cerebral white matter: a variant of corticobasal degeneration?
    Chun Feng Tan
    Department of Pathology, Brain Research Institute, University of Niigata, 1 757 Asahimachi, 951 8585, Niigata, Japan
    Acta Neuropathol 109:329-38. 2005
    ..In conclusion, the possibility that these two cases represent a new neuropathological phenotype of non-familial FTD rather than simply a variant of CBD cannot be completely excluded...
  22. ncbi request reprint TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation
    Chun Feng Tan
    Department of Pathology, Brain Research Institute, University of Niigata, 1 757 Asahimachi, Niigata 951 8585, Japan
    Acta Neuropathol 113:535-42. 2007
    ..These findings indicate that the histological and molecular pathology of SALS can occur as a phenotype of FALS without SOD1 mutation...
  23. ncbi request reprint Disruption of postnatal progenitor migration and consequent abnormal pattern of glial distribution in the cerebrum following administration of methylmercury
    Akiyoshi Kakita
    Department of Pathological Neuroscience, Resource Branch for Brain Disease Research CBBR, Brain Research Institute, Niigata University, Asahimachi, Niigata, Japan
    J Neuropathol Exp Neurol 62:835-47. 2003
    ..Thus, exposure to MeHg in the gliogenic period induced irregular distribution of glia as a consequence of abnormal migration of the postnatal progenitors...
  24. ncbi request reprint Cerebellar involvement in progressive supranuclear palsy: A clinicopathological study
    Masato Kanazawa
    Department of Neurology, Brain Research Institute, Niigata University, Japan
    Mov Disord 24:1312-8. 2009
    ..This study confirms the wide spectrum of clinicopathological manifestations associated with PSP regardless of different ethnic origin, and demonstrates that PSP patients manifest cerebellar ataxia...
  25. ncbi request reprint Apolipoprotein E epsilon4 allele and progression of cortical Lewy body pathology in Parkinson's disease
    K Wakabayashi
    Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
    Acta Neuropathol 95:450-4. 1998
    ..It is possible that when PD occurs in individuals with APOE4, concomitantly evolving cortical LB pathology in a proportion of cases results in limbic (transitional) or neocortical-type LB disease...
  26. ncbi request reprint An autopsy case of autosomal-recessive juvenile parkinsonism with a homozygous exon 4 deletion in the parkin gene
    S Hayashi
    Department of Pathology, Brain Research Institute, Niigata University, Japan
    Mov Disord 15:884-8. 2000
    ..Gene analysis revealed that this autopsied patient and his siblings had the parkin gene mutation (homozygous exon 4 deletion) that is responsible for the disease...
  27. ncbi request reprint Pathological involvement of the motor neuron system and hippocampal formation in motor neuron disease-inclusion dementia
    Yasuko Toyoshima
    Department of Pathology, Brain Research Institute, Niigata University, 1 757 Asahimachi, 951 8585 Niigata, Japan
    Acta Neuropathol 106:50-6. 2003
    ..These findings further strengthen the idea that, pathologically, motor neuron disease-inclusion dementia is a rare phenotype of amyotrophic lateral sclerosis...
  28. ncbi request reprint Familial amyotrophic lateral sclerosis: a SOD1-unrelated Japanese family of bulbar type with Bunina bodies and ubiquitin-positive skein-like inclusions in lower motor neurons
    Asako Tagawa
    Department of Neurology, Shonai Hospital, 4 20 Izumimachi, Tsuruoka, and Department of Pathology, Brain Research Institute, University of Niigata, Japan
    Acta Neuropathol 113:205-11. 2007
    ..Identification of the gene responsible for the disease is desirable in order to shed further light on the molecular pathology of not only familial, but also sporadic, ALS...
  29. doi request reprint TDP-43 mutation in familial amyotrophic lateral sclerosis
    Akio Yokoseki
    Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan
    Ann Neurol 63:538-42. 2008
    ..Our findings provide a new insight into the molecular pathogenesis of ALS...
  30. ncbi request reprint [Clinical and pathological spectrum of TDP-43 associated ALS]
    Osamu Onodera
    Department of Molecular Neuroscience, Center for Bioresource based Researches, Brain Research Institute, Niigata University
    Rinsho Shinkeigaku 50:940-2. 2010
    ..Thus, other factors may contribute to the TDP-43 pathology in these diseases. Further analysis is required to elucidate the molecular mechanism of ALS-10 and TDP-43 proteinopathy...
  31. doi request reprint Sporadic amyotrophic lateral sclerosis: Widespread multisystem degeneration with TDP-43 pathology in a patient after long-term survival on a respirator
    Yasushi Nishihira
    Department of Pathology, Brain Research Institute, University of Niigata, Niigata, Japan
    Neuropathology 29:689-96. 2009
    ..These findings further strengthen the idea that TDP-43 abnormality is closely associated with the pathogenesis of SALS...
  32. doi request reprint Persistent cleavage and nuclear translocation of apoptosis-inducing factor in motor neurons in the spinal cord of sporadic amyotrophic lateral sclerosis patients
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Acta Neuropathol 118:755-62. 2009
    ..Our results provide evidence for persistent cleavage and nuclear translocation of AIF in ALS spinal cord, suggesting implications for the AIF-mediated motor neuron death in this disease...
  33. ncbi request reprint Polyglutamine disease: recent advances in the neuropathology of dentatorubral-pallidoluysian atrophy
    Mitsunori Yamada
    Department of Pathology, Brain Research Institute, Niigata University, Japan
    Neuropathology 26:346-51. 2006
    ..Polyglutamine diseases have a similarity with neuronal storage disease, and this pathological process might become a target for the establishment of an effective therapy for these diseases...
  34. doi request reprint Alzheimer's disease: report of two autopsy cases with a clinical diagnosis of corticobasal degeneration
    Kenichi Okazaki
    Department of Pathology, Brain Research Institute, University of Niigata, Niigata, Japan
    Neuropathology 30:140-8. 2010
    ....
  35. ncbi request reprint Multiplex families with multiple system atrophy
    Kenju Hara
    Departments of Neurology, Center for Bioresource based Researches, Brain Research Institute, Niigata University, Niigata, Japan
    Arch Neurol 64:545-51. 2007
    ..Multiple system atrophy (MSA) has been considered a sporadic disease, without patterns of inheritance...
  36. doi request reprint Biochemical and histopathological alterations in TAR DNA-binding protein-43 after acute ischemic stroke in rats
    Masato Kanazawa
    Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan
    J Neurochem 116:957-65. 2011
    ....
  37. ncbi request reprint Depletion of medullary serotonergic neurons in patients with multiple system atrophy who succumbed to sudden death
    Mari Tada
    Department of Pathology, Brain Research Institute, University of Niigata, Niigata, Japan
    Brain 132:1810-9. 2009
    ....
  38. ncbi request reprint Co-localization of alpha-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration
    Y S Piao
    Department of Pathology, Brain Research Institute, Niigata University, 1-757 Asahimachi, Niigata 951-8585, Japan
    Acta Neuropathol 101:285-93. 2001
    ..We consider that the limbic system can be a major site of neurodegeneration in MSA of long duration. The mechanisms of such abnormal tau accumulation in the NCIs and GCIs are unknown...
  39. doi request reprint Hypertrophic pachymeningitis: significance of myeloperoxidase anti-neutrophil cytoplasmic antibody
    Akiko Yokoseki
    1 Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan
    Brain 137:520-36. 2014
    ....
  40. doi request reprint Sporadic ALS with compound heterozygous mutations in the SQSTM1 gene
    Hiroshi Shimizu
    Department of Pathology, Brain Research Institute, University of Niigata, 1 757 Asahimachi, Chuo Ku, Niigata, 951 8585, Japan
    Acta Neuropathol 126:453-9. 2013
    ..Another feature of interest was concomitant Lewy body pathology. The occurrence of distinct p62 pathology in the LMNs in this patient indicates the pathogenic role of SQSTM1 mutations in the development of a subset of ALS. ..
  41. doi request reprint Suppressed expression of autophagosomal protein LC3 in cortical tubers of tuberous sclerosis complex
    Hiroaki Miyahara
    Department of Pathology, Brain Research Institute, University of Niigata, Niigata, Japan
    Brain Pathol 23:254-62. 2013
    ..Thus, autophagy is suppressed in tubers presumably through the mTOR pathway, and possibly a pathological autophagy reaction occurs in the dysmorphic neurons and balloon cells...
  42. ncbi request reprint A case of congenital supratentorial tumor: atypical teratoid/rhabdoid tumor or primitive neuroectodermal tumor?
    Yasushi Nishihira
    Department of Pathology, Brain Research Institute, University of Niigata, Niigata, Japan
    Neuropathology 27:551-5. 2007
    ..Finally, a diagnosis of PNET, with a rhabdoid phenotype and expression of neuronal and glial markers, was made. In the present case, application of INI1 immunostaining was very helpful for distinguishing PNET from AT/RT...
  43. ncbi request reprint Cerebral lipoma and the underlying cortex of the temporal lobe: pathological features associated with the malformation
    Akiyoshi Kakita
    Department of Pathological Neuroscience, Resource Branch for Brain Disease Research CBBR, Brain Research Institute, University of Niigata, 1 Asahimachi, 951 8585, Niigata, Japan
    Acta Neuropathol 109:339-45. 2005
    ..These findings suggest that focal disturbances in cerebral cortical development occur in association with the development of lipomas...
  44. ncbi request reprint Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease
    Hiroyuki Kaneko
    Department of Molecular Neuroscience, Center for Bioresources, Niigata University, Niigata 951 8585, Japan
    J Neurosci 27:13092-7. 2007
    ....
  45. ncbi request reprint SCA17 homozygote showing Huntington's disease-like phenotype
    Yasuko Toyoshima
    Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan
    Ann Neurol 55:281-6. 2004
    ..Neuronal loss was relatively restricted and most prominent in the Purkinje cell layer and striatum; however, intranuclear neuronal polyglutamine accumulation was widespread, with a high frequency in the cerebral cortex and striatum...
  46. pmc Alteration of POLDIP3 splicing associated with loss of function of TDP-43 in tissues affected with ALS
    Atsushi Shiga
    Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan
    PLoS ONE 7:e43120. 2012
    ..Our results suggest a loss of TDP-43 function in tissues affected with ALS, supporting the hypothesis that a loss of function of TDP-43 underlies the pathogenesis of ALS...
  47. doi request reprint A fatal neuromuscular disease in an adult patient after poliomyelitis in early childhood: consideration of the pathology of post-polio syndrome
    Takayuki Kosaka
    Department of Pathology, Brain Research Institute, University of Niigata Department of Neurology, Nishi Niigata Chuo National Hospital, Niigata, Japan
    Neuropathology 33:93-101. 2013
    ..Was it possible to have diagnosed this patient as having ALS? We consider that the features in this case may have represented the pathology of long-standing and/or fatal PPS itself, and not ALS...
  48. doi request reprint Multiple cerebral infarcts with a few vasculitic lesions in the chronic stage of cerebral amyloid angiopathy-related inflammation
    Kenji Sakai
    Department of Pathology, Brain Research Institute, University of Niigata, Niigata, Japan
    Neuropathology 32:551-6. 2012
    ..In conclusion, we consider that, although the association of PR3-ANCA with the pathogenesis of Aβ-associated vasculitis remained unclear, the present case represents a rare example of CAA-related inflammation at the chronic stage...
  49. doi request reprint Spatiotemporal dynamics of epileptiform propagations: imaging of human brain slices
    Hiroki Kitaura
    Department of Pathology, Brain Research Institute, University of Niigata, Chuo Ku, Niigata, Japan
    Neuroimage 58:50-9. 2011
    ..These findings indicate that synchronized activities of the early phase may play a key role in spreading abnormal discharges in human cortical epilepsies...
  50. doi request reprint Hypertrophy of hippocampal end folium neurons in patients with mesial temporal lobe epilepsy
    Masae Ryufuku
    Department of Pathology, University of Niigata, Japan
    Neuropathology 31:476-85. 2011
    ..Neuronal hypertrophy is evident in patients with epilepsy, and appears to advance gradually as the hippocampal sclerosis becomes more severe. This alteration may be a consequence of cellular stress incurred by neurons...
  51. doi request reprint Increased levels of soluble LR11 in cerebrospinal fluid of patients with Alzheimer disease
    Takeshi Ikeuchi
    Department of Molecular Neuroscience, Brain Research Institute, Niigata University, Niigata, Japan
    Dement Geriatr Cogn Disord 30:28-32. 2010
    ..We have recently established a novel sandwich ELISA, which enabled the sensitive quantification of a soluble LR11 (sLR11). By this ELISA, we attempted to determine the difference in the levels of CSF sLR11 in AD patients...
  52. pmc Severe neurological phenotypes of Q129 DRPLA transgenic mice serendipitously created by en masse expansion of CAG repeats in Q76 DRPLA mice
    Toshiya Sato
    Department of Comparative and Experimental Medicine, Brain Research Institute, Niigata University, Niigata, Japan
    Hum Mol Genet 18:723-36. 2009
    ..Thus, our Q129 mice should be highly valuable for investigating the mechanisms of disease pathogenesis and therapeutic interventions...
  53. ncbi request reprint Primary lateral sclerosis: a rare upper-motor-predominant form of amyotrophic lateral sclerosis often accompanied by frontotemporal lobar degeneration with ubiquitinated neuronal inclusions? Report of an autopsy case and a review of the literature
    Chun Feng Tan
    Department of Pathology, Brain Research Institute, Niigata University, 1 757 Asahimachi, 951 8585, Niigata, Japan
    Acta Neuropathol 105:615-20. 2003
    ....
  54. doi request reprint Activation of signal transducer and activator of transcription-3 in the spinal cord of sporadic amyotrophic lateral sclerosis patients
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Neurodegener Dis 6:118-26. 2009
    ..It is known that signal transducer and activator of transcription-3 (STAT3) is a proinflammatory transcription factor. However, it remains to be determined whether STAT3 is involved in ALS...
  55. ncbi request reprint Sporadic four-repeat tauopathy with frontotemporal degeneration, parkinsonism and motor neuron disease
    Yue Shan Piao
    Department of Pathology, Brain Research Institute, University of Niigata, 1 757 Asahimachi, 951 8585, Niigata, Japan
    Acta Neuropathol 110:600-9. 2005
    ..These findings indicate that a sporadic 4R tauopathy can cause frontotemporal degeneration, parkinsonism, and motor neuron disease. The present case could represent a new clinicopathological phenotype of non-familial tauopathy...
  56. doi request reprint Identification and validation of a gene expression signature that predicts outcome in malignant glioma patients
    Atsushi Kawaguchi
    Department of Neurosurgery, Niigata University, Kyoto, Japan
    Int J Oncol 40:721-30. 2012
    ....
  57. doi request reprint Primary lateral sclerosis: upper-motor-predominant amyotrophic lateral sclerosis with frontotemporal lobar degeneration--immunohistochemical and biochemical analyses of TDP-43
    Takayuki Kosaka
    Department of Pathology, Brain Research Institute, University of Niigata Department of Neurology, Nishi Niigata Chuo National Hospital, Niigata, Japan
    Neuropathology 32:373-84. 2012
    ..In conclusion, we consider that although PLS may be a clinically significant disease entity, at autopsy, the majority of such clinical cases would present as upper-motor-predominant amyotrophic lateral sclerosis with FTLD-TDP...
  58. doi request reprint Periventricular nodular heterotopia functionally couples with the overlying hippocampus
    Hiroki Kitaura
    Department of Pathology, Brain Research Institute, University of Niigata, Niigata, Japan
    Epilepsia 53:e127-31. 2012
    ..The coupling response evoked by stimulation of the subiculum and developing within the heterotopic nodule was enhanced by application of bicuculline. Therefore, activities of the hippocampus and the nodule are closely correlated...
  59. doi request reprint Expression of ErbB4 in substantia nigra dopamine neurons of monkeys and humans
    Yingjun Zheng
    Department of Molecular Neurobiology, Brain Research Institute, University of Niigata, Niigata 951 8585, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:701-6. 2009
    ..These observations suggest that ErbB4 is expressed in the dopaminergic neurons of primate substantia nigra and ErbB4 abnormality might contribute to the dopaminergic pathology associated with schizophrenia or other brain diseases...
  60. doi request reprint Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese
    Norihiro Takei
    Department of Molecular Genetics, Bioresource Science Branch, Center for Bioresources, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    Genomics 93:441-8. 2009
    ..Strong LD between these SNPs was observed (mean |D'|=0.914). These data suggest that the three genes other than APOE, i.e. PVRL2, TOMM40 and APOC1, could also yield a predisposition to LOAD...
  61. doi request reprint Induction of autophagy in temozolomide treated malignant gliomas
    Manabu Natsumeda
    Departments of Neurosurgery Pathology, Brain Research Institute, Niigata University, Niigata, Japan
    Neuropathology 31:486-93. 2011
    ..The present study proved that autophagy monitoring by immunohistochemical staining of surgical specimens was feasible. These results suggest that autophagy is induced by TMZ...
  62. ncbi request reprint Neuropathology with clinical correlations of sporadic amyotrophic lateral sclerosis: 102 autopsy cases examined between 1962 and 2000
    Yue Shan Piao
    Department of Pathology, Brain Research Institute, Niigata University, Japan
    Brain Pathol 13:10-22. 2003
    ..The present findings may be helpful for designing further studies on the mechanisms underlying the development of ALS...
  63. doi request reprint Epidermoid cyst involving the medial temporal lobe: surgical pathologic features of the epileptogenic lesion
    Tetsuya Hiraishi
    Department of Neurosurgery, Brain Research Institute, University of Niigata, Niigata, Japan
    Neuropathology 32:196-201. 2012
    ..This case appears to provide information that is useful for surgical planning in patients with mTLE and epidermoid cysts involving the medial temporal lobe...
  64. ncbi request reprint Accumulation of alpha-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy
    K Wakabayashi
    Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
    Acta Neuropathol 96:445-52. 1998
    ..These findings strongly suggest that the accumulation of NACP is a cytopathological feature common to LB disease and MSA...
  65. ncbi request reprint Autosomal dominant diffuse Lewy body disease
    K Wakabayashi
    Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
    Acta Neuropathol 96:207-10. 1998
    ..The apolipoprotein E genotype of the proband, her uncle and one of their sons was epsilon3/4 and that of the other son was epsilon4/4. These findings strongly suggest that this family has autosomal dominant diffuse LB disease...
  66. ncbi request reprint Pick's disease: selective occurrence of apolipoprotein E-immunoreactive Pick bodies in the limbic system
    S Hayashi
    Department of Pathology, Niigata University, Japan
    Acta Neuropathol 95:1-4. 1998
    ....
  67. doi request reprint Significance of horizontal propagation of synchronized activities in human epileptic neocortex investigated by optical imaging and immunohistological study
    Tetsuya Hiraishi
    Department of Neurosurgery, Brain Research Institute, University of Niigata, Niigata, Japan
    Epilepsy Res 104:59-67. 2013
    ..Further investigations may elucidate the mechanism of hyper-excitability and hyper-synchronization in epileptic cortical tissue itself...
  68. ncbi request reprint [FTLD/ALS as TDP-43 proteinopathies]
    Tomohiko Ishihara
    Department of Neurology, Brain Research Institute, Niigata University
    Rinsho Shinkeigaku 50:1022-4. 2010
    ..Additionally, causative genes of familial FTLD/MND have not been mapped to TDP-43. These results suggest that FTLD/MND is a disease distinct from FTLD and ALS...
  69. doi request reprint Venous congestive myelopathy: three autopsy cases showing a variety of clinicopathologic features
    Koushun Matsuo
    Department of Pathology, Brain Research Institute, University of Niigata, Niigata, Japan
    Neuropathology 28:303-8. 2008
    ..When encountering patients with progressive myelopathy, VCM, although recognized as rare, should be considered as an important differential diagnosis...
  70. doi request reprint Anaplastic astrocytoma with angiocentric ependymal differentiation
    Hiroaki Miyahara
    Department of Pathology, Center for Bioresources, Brain Research Institute, University of Niigata, Chuo Ku, Niigata, Japan
    Neuropathology 31:292-8. 2011
    ..At present, the latter appears to be the more appropriate interpretation...
  71. ncbi request reprint Protein-bound crotonaldehyde accumulates in the spinal cord of superoxide dismutase-1 mutation-associated familial amyotrophic lateral sclerosis and its transgenic mouse model
    Noriyuki Shibata
    Department of Pathology, Neurological Institute, Tokyo Women s Medical University, Tokyo, Japan
    Neuropathology 27:49-61. 2007
    ....
  72. ncbi request reprint Early development of autonomic dysfunction may predict poor prognosis in patients with multiple system atrophy
    Mari Tada
    Department of Neurology, Resource Branch for Brain Disease Research, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata 951 8122, Japan
    Arch Neurol 64:256-60. 2007
    ..Multiple system atrophy (MSA) is diverse in clinical phenotype, disease progression, and prognosis. Sudden death is a leading cause of death in patients with MSA...
  73. doi request reprint Progressive multifocal leukoencephalopathy showing extensive spinal cord involvement in a patient with lymphocytopenia
    Shigeki Takeda
    Department of Pathology, Niigata Neurosurgical Hospital, Nishi ku, Niigata, Japan
    Neuropathology 29:485-93. 2009
    ....
  74. doi request reprint Marinesco-Sjögren syndrome with atrophy of the brain stem tegmentum and dysplastic cytoarchitecture in the cerebral cortex
    Kenji Sakai
    Department of Pathology, Brain Research Institute, University of Niigata, Niigata, Japan
    Neuropathology 28:541-6. 2008
    ..However, we detected no mutations in the available genes. This case appears to represent an unusual example of MSS manifesting widespread developmental anomaly and neuronal degeneration in the CNS...
  75. ncbi request reprint Cerebellar cortical tau pathology in progressive supranuclear palsy and corticobasal degeneration
    Yue Shan Piao
    Department of Pathology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata 951 8585, Japan
    Acta Neuropathol 103:469-74. 2002
    ..In conclusion, we have demonstrated a novel tau pathology that affects Purkinje cells and Bergmann's glia in patients with PSP and CBD, indicating that the cerebellar cortex can be involved in the disease processes in PSP and CBD...
  76. ncbi request reprint Prefrontal abnormality of schizophrenia revealed by DNA microarray: impact on glial and neurotrophic gene expression
    Tetsuji Sugai
    Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    Ann N Y Acad Sci 1025:84-91. 2004
    ..The present profiling study suggests a potential biological link between abnormal neurotrophic signals and impaired glial functions in schizophrenic pathology...
  77. ncbi request reprint Is motor neuron disease-inclusion dementia a forme fruste of amyotrophic lateral sclerosis with dementia? An autopsy case further supporting the disease concept
    Yasuko Toyoshima
    Department of Pathology, Brain Research Institute, University of Niigata, Hospital, Niigata, Japan
    Neuropathology 25:214-9. 2005
    ..In other words, if patients with MND-ID live long enough, they may develop ALS...
  78. pmc Interaction between neuronal intranuclear inclusions and promyelocytic leukemia protein nuclear and coiled bodies in CAG repeat diseases
    M Yamada
    Departments of Pathology, Brain Research Institute, Niigata University, Niigata, Japan
    Am J Pathol 159:1785-95. 2001
    ..The results suggest that the interaction between NIIs and nuclear bodies may play a role in the pathogenesis of CAG repeat diseases...
  79. ncbi request reprint Ubiquitinated neuronal inclusions in the neostriatum in patients with amyotrophic lateral sclerosis with and without dementia--a study of 60 patients 31 to 87 years of age
    K Wakabayashi
    Brain Disease Research Center, Niigata University, Japan
    Clin Neuropathol 20:47-52. 2001
    ..Recently, similar inclusions were reported to occur in the neostriatum in a case of ALS-D. We, therefore, immunohistochemically examined the neostriatum from 60 patients with ALS and 60 control subjects...
  80. ncbi request reprint Involvement of the cerebral cortex and autonomic ganglia in Machado-Joseph disease
    M Yamada
    Department of Pathology, Brain Research Institute, Niigata University, Japan
    Acta Neuropathol 101:140-4. 2001
    ..These lesions, newly recognized by polyglutamine immunohistochemistry, may be responsible for the cerebral cortical dysfunctions or autonomic abnormalities pointed out in MJD patients by the recent clinical and neuroradiological studies...
  81. ncbi request reprint Widespread occurrence of intranuclear atrophin-1 accumulation in the central nervous system neurons of patients with dentatorubral-pallidoluysian atrophy
    M Yamada
    Department of Pathology, Brain Research Institute, Niigata University, Japan
    Ann Neurol 49:14-23. 2001
    ....
  82. ncbi request reprint NACP/alpha-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson's disease brains
    K Wakabayashi
    Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
    Acta Neuropathol 99:14-20. 2000
    ..The number of inclusions was correlated with the severity of nigral neuronal loss. These findings indicate that abnormal accumulation of NACP/alpha-synuclein in glial cells is a pathological feature of PD related to its progression...
  83. ncbi request reprint Patients with temporal lobe epilepsy show an increase in brain-derived neurotrophic factor protein and its correlation with neuropeptide Y
    M Takahashi
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    Brain Res 818:579-82. 1999
    ..Thus, these results indicate the activity-dependent expression of BDNF in human subjects and its potential contribution to the pathophysiology of human epilepsy via neuropeptide Y...
  84. ncbi request reprint Novel mutations, pseudo-dominant inheritance, and possible familial affects in patients with autosomal recessive juvenile parkinsonism
    M Maruyama
    Department of Neurology, Brain Research Institute, Niigata University, Japan
    Ann Neurol 48:245-50. 2000
    ..In 1 family, in which an autosomal dominant mode of inheritance was suspected, multiple mutant alleles were identified. Although a wide range of ages at onset was observed, there was no correlation between age at onset and genotype...
  85. ncbi request reprint Ganglioglioma with a tanycytic ependymoma as the glial component
    S Hayashi
    Department of Pathology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata 951 8585, Japan
    Acta Neuropathol 99:310-6. 2000
    ..The occurrence of NFTs, which has been reported in several cases of GG, was an additional, unusual feature...
  86. ncbi request reprint Immunocytochemical detection of superoxide dismutases (SODs) in the periodontal Ruffini endings of the rat incisor
    H Yamamoto
    Division of Oral and Maxillofacial Anatomy, Department of Oral Biological Science, Graduate School of Medical and Dental Sciences, Niigata University, 2 5274 Gakkocho dori, Niigata 951 8514, Japan
    Brain Res 905:232-5. 2001
    ..It is likely that Mn-SOD in the axon terminals of mechanoreceptors exerts protective action against nerve injury and neuronal death under severe conditions, serving to scavenge free radicals from the axon terminals...
  87. ncbi request reprint The development of terminal Schwann cells associated with periodontal Ruffini endings in the rat incisor ligament
    S Hayashi
    Department of Oral Anatomy, Faculty of Dentistry, Niigata University, Niigata, Japan
    Brain Res 858:167-71. 2000
    ..This suggests that the terminal Schwann cell is important in the development and maturation of the periodontal Ruffini endings...
  88. pmc Bcl-2 expression and frequency of apoptosis correlate with morphogenesis of colorectal neoplasia
    Y Suzuki
    Third Department of Internal Medicine, Niigata University School of Medicine, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    J Clin Pathol 55:212-6. 2002
    ..To investigate whether the expression of apoptosis and cell proliferation related proteins is related to the macroscopic form of colorectal neoplasia...
  89. ncbi request reprint Immunocytochemical detection of S-100beta in the periodontal Ruffini endings in the rat incisor
    K Nakakura-Ohshima
    Department of Pedodontics, Niigata University School of Dentistry, Japan
    Neurosci Lett 258:163-6. 1998
    ..The present findings indicated the existence of S-100beta, not S-100alpha, in axon terminals of the periodontal mechanoreceptive endings which were identified as type II Ruffini endings...
  90. ncbi request reprint Bilateral maxillary fused primary incisors accompanied by succedaneous supernumerary teeth: report of a case
    M Tomizawa
    Division of Paediatric Dentistry, Niigata University Graduate School of Medical and Dental Sciences, 2 5274 Gakkocho dori, Niigata 951 8514, Japan
    Int J Paediatr Dent 12:223-7. 2002
    ..After 6 months observation, surgical exposure of the two crowns of the permanent maxillary central incisors was performed. The teeth began to erupt and have since been kept under observation...
  91. pmc TT virus infection is widespread in the general populations from different geographic regions
    K Abe
    Department of Pathology, National Institute of Infectious Diseases, Japan
    J Clin Microbiol 37:2703-5. 1999
    ..This suggests that TTV may be a common DNA virus with no clear disease association in humans. TTV genotyping by phylogenetic analysis was also performed...
  92. pmc Rapid and specific genotyping system for hepatitis B virus corresponding to six major genotypes by PCR using type-specific primers
    H Naito
    Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
    J Clin Microbiol 39:362-4. 2001
    ..This assay system is considered to be a useful tool for the molecular diagnosis of HBV infection and for large-scale surveys...
  93. ncbi request reprint Aprosencephaly: histopathological features of the rudimentary forebrain and retina
    A Kakita
    Department of Pathology, Brain Research Institute, Niigata University, Japan
    Acta Neuropathol 102:110-6. 2001
    ..This case seems to represent a primary malformation, and the features imply that the failure occurs after neurulation and before the prosencephalic medium began its growth...
  94. ncbi request reprint Flt3/Flk-2 and c-Kit are not essential for the proliferation of B lymphoid progenitor cells in the bone marrow of the adult mouse
    M Ogawa
    Department of Molecular Genetics, Faculty of Medicine, Kyoto University, Japan
    Exp Hematol 26:478-88. 1998
    ....
  95. ncbi request reprint Reduced HIC-1 gene expression in non-small cell lung cancer and its clinical significance
    M Hayashi
    Laboratory of Cancer Diagnosis and Therapy, Saitama Cancer Center Research Institute, Saitama, Japan
    Anticancer Res 21:535-40. 2001
    ..034), an association also observed in cases restricted to stage I (P = 0.047). CONCLUSIONS: The results suggest that low HIC-1 expression is involved in malignant progression of non-small cell lung cancer...
  96. ncbi request reprint Role of APAF-1, E-cadherin and peritumoral lymphocytic infiltration in tumour budding in colorectal cancer
    I Zlobec
    Department of Pathology, McGill University, Montreal, Canada
    J Pathol 212:260-8. 2007
    ..Loss of E-cadherin and APAF-1 within the main body of CRCs are independent predictors of tumour budding. The prognostic benefit of lymphocytic infiltration may be explained by the immune destruction of budding cells...
  97. ncbi request reprint Structure, expression and chromosomal localization of the gene encoding human 2',3'-cyclic-nucleotide 3'-phosphodiesterase
    K Monoh
    Brain Research Institute, Niigata University, Japan
    Gene 129:297-301. 1993
    ..Spot blot hybridization of flow-sorted human chromosomes with the 3'-noncoding region of the human CNP cDNA showed the localization of CNP to chromosome 17...
  98. pmc Biogenesis of membrane lipoproteins in Escherichia coli
    H C Wu
    Biophys J 37:307-15. 1982
    ..This speculation is confirmed by our demonstration that Bacillus licheniformis penicillinase synthesized in E. coli as well as in B. licheniformis is a lipoprotein containing glyceride-cysteine at its NH2-terminus...
  99. ncbi request reprint Kinase-independent activity of Cdc2/cyclin A prevents the S phase in the Drosophila cell cycle
    S Hayashi
    National Institute of Genetics and The Graduate School for Advanced Studies, 1111 Yata, Mishima, Shizuoka ken 411 8540, Japan
    Genes Cells 4:111-22. 1999
    ..Whether this is the sole mechanism of S phase inhibition by Cdc2 in higher metazoans is not known because the pleiotropic functions of this essential cell cycle regulator make genetic analysis difficult...
  100. ncbi request reprint Fractalkine in the peritoneal fluid of women with endometriosis
    K Shimoya
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita City, Osaka 565 0871, Japan
    Int J Gynaecol Obstet 91:36-41. 2005
    ..The objective of this study was to evaluate the presence of fractalkine in the ascites and the association between fractalkine levels in the ascites and endometriosis...
  101. pmc A simple and reproducible scoring system for EGFR in colorectal cancer: application to prognosis and prediction of response to preoperative brachytherapy
    I Zlobec
    Department of Pathology, McGill University, Montreal, Quebec, Canada
    Br J Cancer 96:793-800. 2007
    ..001). Epidermal growth factor receptor is a predictive marker of response to preoperative radiotherapy and an independent adverse prognostic factor CRC...