Research Topics
Genomes and GenesSpecies | Yoshio ShiraiSummaryAffiliation: Niigata University Country: Japan Publications
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Publications
Intraoperative assessment of the resectability of hilar cholangiocarcinomaYoshio Shirai
Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
Hepatogastroenterology 59:2436-8. 2012..In conclusion, this simple technique, isolation of the right hepatic artery behind Calot's triangle before start-ing resection, should be applied to all hilar malignancies when a left-sided hepatectomy is planned...
"Extended" radical cholecystectomy for gallbladder cancer: long-term outcomes, indications and limitationsYoshio Shirai
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951 8510, Japan
World J Gastroenterol 18:4736-43. 2012..To delineate indications and limitations for "extended" radical cholecystectomy for gallbladder cancer: a procedure which was instituted in our department in 1982...- Assessment of lymph node status in gallbladder cancer: location, number, or ratio of positive nodesYoshio Shirai
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City 951 8510, Japan
World J Surg Oncol 10:87. 2012..The aim of this study was to compare the anatomical location of positive nodes, number of positive nodes, and lymph node ratio (LNR) as prognostic predictors in gallbladder cancer... 
Full-thickness cholecystectomy with limited lymphadenectomy for gallbladder cancerYoshio Shirai
Niigata University, Niigata City, Japan
Hepatogastroenterology 59:1338-40. 2012..This less invasive procedure can be applied to patients with advanced age and/or comorbid disease(s), provided that the tumor is apparently confined to the gallbladder wall and has no gross evidence of distant metastases/nodal disease...- Regional lymphadenectomy for gallbladder cancer: rational extent, technical details, and patient outcomesYoshio Shirai
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951 8510, Japan
World J Gastroenterol 18:2775-83. 2012..To define the rational extent of regional lymphadenectomy for gallbladder cancer and to clarify its effect on long-term survival... - Radical lymph node dissection for gallbladder cancer: indications and limitationsYoshio Shirai
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City, 951 8510 Japan
Surg Oncol Clin N Am 16:221-32. 2007..Extended resection with extensive lymphadenectomy should be limited to expert surgeons because it may cause serious morbidity and mortality... - Clinical significance of lymph node micrometastasis in ampullary carcinomaEiko Sakata
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City 951 8510, Japan
World J Surg 30:985-91. 2006..This study aimed to clarify the clinical significance of lymph node micrometastasis in ampullary carcinoma... - Assessment of the nodal status in ampullary carcinoma: the number of positive lymph nodes versus the lymph node ratioJun Sakata
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata City, 951 8510, Japan
World J Surg 35:2118-24. 2011..This study was intended to compare the prognostic power of the number of positive lymph nodes with that of the lymph node ratio in patients with ampullary carcinoma... - Fucosylated fraction of alpha-fetoprotein as a predictor of prognosis in patients with hepatocellular carcinoma after curative treatmentYasushi Tamura
Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata, Japan
Dig Dis Sci 55:2095-101. 2010..The aim of this study was to evaluate the clinical usefulness of measuring the Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3) for prognostic predictor in patients with hepatocellular carcinoma (HCC)... - Overexpression of osteopontin independently correlates with vascular invasion and poor prognosis in patients with hepatocellular carcinomaPavel V Korita
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951 8510, Japan
Hum Pathol 39:1777-83. 2008..These results suggest that overexpression of osteopontin independently correlates with vascular invasion and thus predicts poor survival for patients with HCC, whereas aberrant expression of E-cadherin or beta-catenin does not... - Prognostic significance of NQO1 expression in intrahepatic cholangiocarcinomaToshifumi Wakai
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences Niigata, Japan
Int J Clin Exp Pathol 4:363-70. 2011..001) and loss of NQO1 expression (p<0.001) had an independent adverse effect on survival. Loss of NQO1 expression reflects dedifferentiation and thus indicates a poor prognosis for patients undergoing resection for ICC... - Appraisal of 1 cm hepatectomy margins for intrahepatic micrometastases in patients with colorectal carcinoma liver metastasisToshifumi Wakai
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata City, 951 8510, Japan
Ann Surg Oncol 15:2472-81. 2008..This study sought to clarify the distribution of intrahepatic micrometastases and elucidate an adequate hepatectomy margin for colorectal carcinoma liver metastases... - Major hepatic resection reduces the probability of intrahepatic recurrences following resection of colorectal carcinoma liver metastasesShigenori Nagakura
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata City, 951-8510 Japan
Hepatogastroenterology 50:779-83. 2003..CONCLUSIONS: Major hepatic resection is more effective in reducing the risk of intrahepatic recurrences than limited hepatic resection in patients with resectable colorectal carcinoma liver metastases... - Intrahepatic lymphatic invasion independently predicts poor survival and recurrences after hepatectomy in patients with colorectal carcinoma liver metastasesPavel V Korita
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata City, 951 8510, Japan
Ann Surg Oncol 14:3472-80. 2007..We hypothesized that intrahepatic lymphatic invasion reflects the nodal status of colorectal carcinoma liver metastases and may function as an adverse prognostic factor... - Loss of carcinoembryonic antigen-related cell adhesion molecule 1 expression predicts metachronous pulmonary metastasis and poor survival in patients with hepatoblastomaMami Tsukada
Division of Pediatric Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951 8510, Japan
J Pediatr Surg 44:1522-8. 2009..The aim of this study was to test the hypothesis that loss of CEACAM1 expression in hepatoblastoma cells may promote hematogeneous metastasis and function as an adverse prognostic factor... - Catheter tract implantation metastases associated with percutaneous biliary drainage for extrahepatic cholangiocarcinomaJun Sakata
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata City 951-8510, Japan
World J Gastroenterol 11:7024-7. 2005..Although the prognosis for patients with this complication is generally poor, the excision of the catheter tract may enable survival in selected patients with isolated metastases along the catheter tract... - Reduced NKG2D ligand expression in hepatocellular carcinoma correlates with early recurrenceHiroteru Kamimura
Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
J Hepatol 56:381-8. 2012.... - Ribonucleotide reductase M1 expression in intrahepatic cholangiocarcinomaToshifumi Wakai
Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Hepatogastroenterology 58:1659-63. 2011.... - Loss of liver-intestine cadherin in human intrahepatic cholangiocarcinoma promotes angiogenesis by up-regulating metal-responsive transcription factor-1 and placental growth factorMasaaki Takamura
Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachi dori 1, Chuo Ku, Niigata 951 8510, Japan
Int J Oncol 36:245-54. 2010..Loss of LI-cadherin results in up-regulation of MTF-1 and PlGF, thereby regulating angiogenesis in ICC... - Preoperative cholangitis independently increases in-hospital mortality after combined major hepatic and bile duct resection for hilar cholangiocarcinomaJun Sakata
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata, Japan
Langenbecks Arch Surg 394:1065-72. 2009..This study evaluated the impact of ductal bile bacteria (bactibilia or cholangitis) on the development of surgical site infection (SSI) or in-hospital mortality after resection for hilar cholangiocarcinoma... - Clinical significance of intracapsular and extratumoral venous invasion in hepatocellular carcinomaMasanori Ohashi
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata City 951 8510, Japan
Hepatogastroenterology 57:611-5. 2010..The current study sought to clarify whether intracapsular venous invasion and extratumoral venous invasion confer different prognostic significance in patients undergoing hepatectomy for hepatocellular carcinoma... - Low preoperative platelet counts predict a high mortality after partial hepatectomy in patients with hepatocellular carcinomaKazuhiro Kaneko
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Japan
World J Gastroenterol 11:5888-92. 2005..The preoperative platelet count independently affects morbidity and mortality after hepatectomy, suggesting that a combination of K(ICG) and platelet count would further reduce postoperative mortality... - Depth of invasion determines the postresectional prognosis for patients with T1 extrahepatic cholangiocarcinomaMasayuki Nagahashi
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951 8510, Japan
Cancer 116:400-5. 2010.... - Histological evaluation of intracapsular venous invasion for discrimination between portal and hepatic venous invasion in hepatocellular carcinomaMasanori Ohashi
Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
J Gastroenterol Hepatol 25:143-9. 2010..Histological criteria for intracapsular venous invasion (IVI) that would allow its discrimination between portal and hepatic venous invasion in hepatocellular carcinoma (HCC) have not been established... - Multidrug resistance-associated protein 2 determines the efficacy of cisplatin in patients with hepatocellular carcinomaPavel V Korita
Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
Oncol Rep 23:965-72. 2010..Expression of MRP2 determines the efficacy of cisplatin-based chemotherapy in patients with HCC... - Hepatic lymph node dissection provides a survival benefit for patients with nodal disease of colorectal carcinoma liver metastasesToshifumi Wakai
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata City 951 8510, Japan
Hepatogastroenterology 56:186-90. 2009..This retrospective study aimed to define the role of hepatic lymph node dissection in the surgical management of patients with resectable colorectal carcinoma liver metastases... - Clinicopathological features of benign biliary strictures masquerading as biliary malignancyToshifumi Wakai
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Am Surg 78:1388-91. 2012..Although benign biliary strictures are rare, differentiating benign strictures from malignancy remains problematic. Thus, the treatment approach for biliary strictures should remain surgical resection for presumed biliary malignancy... - Depth of subserosal invasion predicts long-term survival after resection in patients with T2 gallbladder carcinomaToshifumi Wakai
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Ann Surg Oncol 10:447-54. 2003..Among patients with inapparent pT2 tumors, those with subserosal invasion >2 mm are good candidates for radical second resection... - Histologic evaluation of intrahepatic micrometastases in patients treated with or without neoadjuvant chemotherapy for colorectal carcinoma liver metastasisToshifumi Wakai
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Int J Clin Exp Pathol 5:308-14. 2012..313 and p=0.526, respectively). In conclusion, NAC reduces the incidence of intrahepatic micrometastases in patients with CRLM, but NAC has no significant effect on their distribution when intrahepatic micrometastases are present... - Liver-intestine cadherin in intraepithelial neoplasia of intrahepatic cholangiocarcinomaMakoto Inoue
Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Hepatogastroenterology 58:2045-51. 2011..The aim of this study was to identify factors associated with LI-cadherin expression in biliary intraepithelial lesions of intrahepatic cholangiocarcinoma (ICC)... - Mode of hepatic spread from gallbladder carcinoma: an immunohistochemical analysis of 42 hepatectomized specimensToshifumi Wakai
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Am J Surg Pathol 34:65-74. 2010..The mode of hepatic spread independently predicts long-term survival after resection for patients with gallbladder carcinoma. Hepatic metastatic nodules indicate a dismal outcome after resection... - Jaundice at presentation heralds advanced disease and poor prognosis in patients with ampullary carcinomaNaoyuki Yokoyama
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori 1-757, Niigata, 951-8510, Japan
World J Surg 29:519-23. 2005..0014). In conclusion, jaundice at presentation predicts advanced-stage ampullary carcinoma and a poor prognosis. Pancreatic invasion and superior mesenteric nodal involvement were not observed in nonjaundiced patients... - Alteration of p53-binding protein 1 expression as a risk factor for local recurrence in patients undergoing resection for extrahepatic cholangiocarcinomaToshifumi Wakai
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
Int J Oncol 38:1227-36. 2011..0% at 5 years; P=0.020). In conclusion, after resection for extrahepatic cholangiocarcinoma, clinically evident local recurrence at ductal stumps is closely associated with 53BP1 inactivation and decreased apoptosis... - Anatomic resection independently improves long-term survival in patients with T1-T2 hepatocellular carcinomaToshifumi Wakai
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City 951 8510, Japan
Ann Surg Oncol 14:1356-65. 2007..This study aimed to evaluate the effect of anatomic resection on long-term outcomes in patients with pathologic T1-T2 (pT1-T2) hepatocellular carcinoma... - Impact of ductal resection margin status on long-term survival in patients undergoing resection for extrahepatic cholangiocarcinomaToshifumi Wakai
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Cancer 103:1210-6. 2005..CONCLUSIONS: After surgical resection for extrahepatic cholangiocarcinoma, invasive carcinoma at ductal resection margins appears to have a strong adverse effect on patient survival, whereas residual carcinoma in situ does not... - Intraepithelial ductal spread in colorectal carcinoma liver metastasisToshifumi Wakai
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata, Japan
Hepatogastroenterology 58:583-8. 2011..This study aimed to evaluate the usefulness of immunohistochemical combinations for discrimination between intraepithelial ductal spread of colorectal carcinoma liver metastasis (CRLM) and that of intrahepatic cholangiocarcinoma (ICC)... - FK506 may reduce early liver injury following living related liver transplantationTakashi Kato
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Science Niigata, Japan
Hepatogastroenterology 53:580-3. 2006..These findings might suggest that cell-mediated immunity weigh heavier than the operation time of ischemia-reperfusion injury as a cause of liver injury after partial hepatectomy... - Long-term outcomes of hepatectomy vs percutaneous ablation for treatment of hepatocellular carcinoma < or =4 cmToshifumi Wakai
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata 951-8510, Japan
World J Gastroenterol 12:546-52. 2006..Of the patients with HCC < or =4 cm, those with tumors >2 cm are good candidates for hepatectomy, provided that the hepatic functional reserve of the patient permits resection... - Number of positive lymph nodes independently determines the prognosis after resection in patients with gallbladder carcinomaJun Sakata
Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
Ann Surg Oncol 17:1831-40. 2010..This study was designed to compare the prognostic power of the location of positive lymph nodes with that of the number of positive lymph nodes in gallbladder carcinoma... - Aberrant expression of vimentin correlates with dedifferentiation and poor prognosis in patients with intrahepatic cholangiocarcinomaPavel V Korita
Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
Anticancer Res 30:2279-85. 2010..This study aimed to elucidate the prognostic value of vimentin expression in patients with intrahepatic cholangiocarcinoma (ICC)... - Adenosquamous carcinoma of the gallbladder warrants resection only if curative resection is feasibleYasuhiro Oohashi
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
Cancer 94:3000-5. 2002..Residual tumor status (P = 0.026) was the only significant independent prognostic factor. CONCLUSIONS: Adenosquamous/squamous cell carcinoma of the gallbladder warrants resection only if potentially curative (R0) resection is feasible... - Perimuscular connective tissue contains more and larger lymphatic vessels than the shallower layers in human gallbladdersMasayuki Nagahashi
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City, Japan
World J Gastroenterol 13:4480-3. 2007..To clarify whether perimuscular connective tissue contains more lymphatic vessels than the shallower layers in human gallbladders... - Combined major hepatectomy and pancreaticoduodenectomy for locally advanced biliary carcinoma: long-term resultsToshifumi Wakai
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
World J Surg 32:1067-74. 2008..This study aimed to define the role of combined major hepatectomy and pancreaticoduodenectomy in the surgical management of biliary carcinoma and to identify potential candidates for this aggressive procedure... - Narrow portion of the terminal choledochus is a cause of upstream biliary dilatation in patients with anomalous union of the pancreatic and biliary ductsTatsuya Nomura
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 Asahimachi-dori, Niigata, 951-8510, Japan
World J Gastroenterol 11:6503-7. 2005..CONCLUSION: The narrow portion of the terminal choledochus, a pathognomonic radiologic feature of AUPBD, may be a cause of biliary dilatation in patients with AUPBD... - Morphological features of early gallbladder carcinomaToshifumi Wakai
Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Hepatogastroenterology 59:1013-7. 2012..This study aimed to clarify the morphological features of early gallbladder carcinoma including tumors invading the lamina propria (pT1a) or muscular layer (pT1b)... - Surgical outcomes for hepatocellular carcinoma in nonalcoholic fatty liver diseaseToshifumi Wakai
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, 951 8510, Japan
J Gastrointest Surg 15:1450-8. 2011..The present study investigated outcomes following surgical resection of hepatocellular carcinoma (HCC) in nonalcoholic fatty liver disease (NAFLD)... - An 11-year survivor who underwent ten sequential resections of colonic adenocarcinoma metastasesShigenori Nagakura
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata City, 951-8510 Japan
Hepatogastroenterology 50:1032-3. 2003..Surgeons should pursue resection for colorectal carcinoma metastases, regardless of frequent operations and sites involved, as reliable medical treatment remains unestablished... - Progression of hypermethylation of the p16(INK4A) gene from normal liver to nontumorous liver and hepatocellular carcinoma: an evaluation using quantitative PCR analysisSo Kurita
Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences of Niigata University, 1 754, Asahimachi Dori, Niigata City, 951 8122, Japan
Dig Dis Sci 54:80-8. 2009..There may be a greater proportion of cells which contain methylated p16 in nontumorous than in normal liver. However, the difference was so small that the functional relevance to hepatocarcinogenesis remains elusive... - Tumor suppressor carcinoembryonic antigen-related cell adhesion molecule 1 potentates the anchorage-independent growth of human hepatoma HepG2 cellsMariko Hokari
Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi dori 1 757, Niigata 951 8510, Japan
Life Sci 81:336-45. 2007.... - Humoral hypercalcemia complicating adenocarcinoma of the sigmoid colon: report of a caseJun Sakata
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata 951-8510, Japan
Surg Today 35:692-5. 2005.... - Radical second resection provides survival benefit for patients with T2 gallbladder carcinoma first discovered after laparoscopic cholecystectomyToshifumi Wakai
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata City, 951-8510, Japan
World J Surg 26:867-71. 2002..Radical second resection may be beneficial for patients with pT2 gallbladder carcinoma first discovered after laparoscopic cholecystectomy... - Risk of subsequent biliary malignancy in patients undergoing cyst excision for congenital choledochal cystsTaku Ohashi
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
J Gastroenterol Hepatol 28:243-7. 2013..The aim of this study was to elucidate the risk of subsequent biliary malignancy in patients undergoing cyst excision for congenital choledochal cysts... - Aberrant expression of pRb and p16(INK4), alone or in combination, indicates poor outcome after resection in patients with colorectal carcinomaXing Cui
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
Hum Pathol 35:1189-95. 2004..994, P <0.0001, respectively). Most CRCs demonstrate aberrant expression of pRb and/or p16 at resectable stages. Aberrant expression of pRb and p16, alone and in combination, heralds poor prognosis in patients with CRC... - Surgical outcomes of minor hepatectomy for locally advanced gallbladder carcinomaToshifumi Wakai
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Hepatogastroenterology 59:2083-8. 2012..This study aimed to evaluate whether wedge resection or S4bS5 resection was the more beneficial hepatectomy procedure for patients with locally advanced gallbladder carcinoma... - Early DNA damage response in residual carcinoma in situ at ductal stumps and local recurrence in patients undergoing resection for extrahepatic cholangiocarcinomaToshifumi Wakai
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata, 951 8510, Japan
J Hepatobiliary Pancreat Sci 20:362-9. 2013.... - Loss of carcinoembryonic antigen-related cell adhesion molecule 1 expression is an adverse prognostic factor in hepatocellular carcinomaPauldion V Cruz
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Cancer 104:354-60. 2005..The authors hypothesized that loss of CEACAM1 expression in hepatocellular carcinoma (HCC) cells may function as an adverse prognostic factor... - Genetic changes of p53, K-ras, and microsatellite instability in gallbladder carcinoma in high-incidence areas of Japan and HungaryMasayuki Nagahashi
Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
World J Gastroenterol 14:70-5. 2008..To disclose geographic differences in genetic changes involved in gallbladder carcinogenesis between two distinct high-incidence areas of Japan and Hungary... - Increased risk of cholelithiasis after esophagectomyKazuhiko Tsunoda
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, 951-8510, Niigata, Japan
J Hepatobiliary Pancreat Surg 11:319-23. 2004..012, Fisher's exact test). CONCLUSIONS: Esophagectomy yields an increased risk of the development of cholelithiasis. Truncal vagotomy and postsurgical malnutrition may contribute to this increased gallstone formation after esophagectomy... - Long-term survival after resection of colonic adenocarcinoma with synchronous metastases to the liver, adrenal gland, and aortic-caval lymph nodes: report of a caseShigenori Nagakura
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
Dis Colon Rectum 45:1679-80. 2002 - Peroral cholangioscopy for non-invasive papillary cholangiocarcinoma with extensive superficial ductal spreadToshifumi Wakai
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata, Niigata 951-8510, Japan
World J Gastroenterol 11:6554-6. 2005.... - Gallbladder carcinoma presenting as exfoliative dermatitis (erythroderma)Hitoshi Kameyama
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Int J Gastrointest Cancer 35:153-5. 2005..The experience of the current patient suggests that erythroderma secondary to GI malignancy may resolve spontaneously after curative resection of the tumor... - Dynamic computed tomography findings of malignant intraductal papillary mucinous tumor compared with invasive ductal adenocarcinomaToshiro Ozaki
Department of Radiation Oncology, Niigata Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
Radiat Med 25:446-52. 2007..We evaluated the effectiveness of dynamic computed tomography (CT) imaging in differentiating malignant intraductal papillary mucinous tumor (IPMT) with a large mural nodule from invasive ductal adenocarcinoma (IDAC)... - Treatment of a case with right-sided diaphragmatic hernia associated with an abnormal vessel communication between a herniated liver and the right lungShinji Tanaka
Department of Pediatric Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan
J Pediatr Surg 41:e25-8. 2006..When performing surgery on a right-sided diaphragmatic hernia, the potential presence of such a vessel anomaly should be carefully taken into consideration... - Hemangiopericytoma arising in the greater omentum: report of a caseKazuhiro Kaneko
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata 951-8510, Japan
Surg Today 33:722-4. 2003..A review of the reported cases suggests that surgical resection provides the only chance of cure and that a high mitotic index (>4/10 high-power fields) and a tumor size of > or =20 cm predict an unfavorable prognosis after resection... - Segmental adenomyomatosis of the gallbladder predisposes to cholecystolithiasisAtsushi Nishimura
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, 951-8510, Niigata, Japan
J Hepatobiliary Pancreat Surg 11:342-7. 2004..Fundal or diffuse adenomyomatosis appears to be unrelated to cholecystolithiasis... - Synchronous development of HCC and CCC in the same subsegment of the liver in a patient with type C liver cirrhosisTakuya Watanabe
Takuya Watanabe, Haruka Hirono, Katsuhiko Hasegawa, Kenji Soga, Koichi Shibasaki, Department of Internal Medicine and Gastroenterology, Medical Hospital, The Nippon Dental University School of Life Dentistry at Niigata, 1 8, Hamauracho, Chuo Ku, Niigata 951 8580, Japan
World J Hepatol 1:103-9. 2009..We also add a literature review for all the reported cases published in Japan and around the world, and summarize the features of double cancer exhibiting both HCC and CCC... - Postoperative management for donor safety in living related donor liver transplantationYoshinobu Sato
First Department of Surgery, School of Medicine, Niigata University, 1-757 Asahimachi-dori, Niigata 951-8510, Japan
Hepatogastroenterology 50:196-200. 2003.... - Prevalence of cholesterol gallstones positively correlates with per capita daily calorie intakeKazuhiko Tsunoda
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
Hepatogastroenterology 51:1271-4. 2004..Per capita daily total calorie intake appears to be the predominant dietary factor affecting cholesterol gallstone prevalence... - Immunohistochemically detected hepatic micrometastases predict a high risk of intrahepatic recurrence after resection of colorectal carcinoma liver metastasesNaoyuki Yokoyama
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
Cancer 94:1642-7. 2002..Hepatic micrometastasis indicates widespread hepatic involvement and thus predicts an increased risk of intrahepatic recurrence after hepatic resection and a poorer patient prognosis... - [Second-line chemotherapy with pharmacokinetic modulating chemotherapy for unresectable colorectal carcinoma recurrences resistant to 5-FU-based chemotherapy]Katsuki Muneoka
Dept. of Surgery, Niitsu Medical Center Hospital
Gan To Kagaku Ryoho 33:779-82. 2006..PMC with a dose increase of 5-FU is recommended as a promising second-line regimen for unresectable colorectal carcinoma resistant to 5-FU... - Multiple repeat resections of intra- and extrahepatic recurrences in patients undergoing initial hepatectomy for colorectal carcinoma metastasesShigenori Nagakura
Department of Surgery, Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata City 951-8510, Japan
World J Surg 26:141-7. 2002..Repeat resection should be considered for any resectable recurrences after hepatectomy... - [Pharmacokinetic modulating chemotherapy highly effective for colorectal carcinoma metastases to multiple organs]Katsuki Muneoka
Dept. of Surgery, Niitsu Medical Center Hospital, Niigata University Graduate School of Medical and Dental Sciences
Gan To Kagaku Ryoho 32:799-802. 2005..Pulmonary metastases are more resistant to 5-FU than hepatic metastases, as they require a higher 5-FU AUC to respond... - [Pharmacokinetic modulating chemotherapy for rectal carcinoma metastases to the liver and lung--a case report]Katsuki Muneoka
Dept of Surgery, Niitsu Medical Center Hospital
Gan To Kagaku Ryoho 32:231-3. 2005..The high serum 5-FU concentrations at night suggest the chronomodulating nature of PMC and are effective for metastatic colorectal carcinoma... - Chronic oral exposure to inorganic arsenate interferes with methylation status of p16INK4a and RASSF1A and induces lung cancer in A/J miceXing Cui
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305 8506, Japan
Toxicol Sci 91:372-81. 2006..In conclusion, iAs(V) exposure increased lung tumor incidence and multiplicity in A/J mice. Epigenetic changes of tumor suppressor genes such as p16INK4a and RASSF1A are involved in the iAs(V)-induced lung carcinogenesis... - Two-step hepatectomy using right portal vein ligation for multiple bilobar hepatocellular carcinomas arising in injured liverToshifumi Wakai
Surgery 137:124. 2005 - Liver regeneration enhanced by orally administered ursodesoxycholic acid is mediated by immunosuppression in partially hepatectomized ratsLili Liu
The First Department of Surgery, Niigata University School of Medicine, Japan
Am J Chin Med 30:119-26. 2002..It was also noted that UDCA did not affect serum parameters indicating liver and kidney function. These findings suggest that liver regeneration can be modified by orally administered UDCA through a change in immunoactivity... - Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cellsXing Cui
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305 8506, Japan
Hum Pathol 37:298-311. 2006..In conclusion, a low concentration of As2O3 induces CpG island demethylation of tumor suppressor genes by inhibition of DNMT and reactivates the partially/fully silenced genes in liver cancer cells... - [Irinotecan plus gemcitabine(IRINOGEM)in the treatment of biliary malignancies]Katsuki Muneoka
Depts of Surgery, Niitsu Medical Center Hospital
Gan To Kagaku Ryoho 35:61-4. 2008..The present study was conducted to evaluate the effects of irinotecan plus gemcitabine(IRINOGEM)on biliary malignancies... - 5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanineKatsuki Muneoka
Department of Surgery, Niitsu Medical Center Hospital, Niigata, Japan
Int J Clin Oncol 10:441-3. 2005..The experience of this case, together with a review of the literature, suggests that FBAL is related to 5-FU-induced cardiotoxicity. S-1 may be administered safely to patients with 5-FU-induced cardiotoxicity... - [Surgical therapy for colorectal neoplasms--surgical removal of hepatic metastases and rectal neoplasms]Tsuneo Iiai
Nippon Naika Gakkai Zasshi 96:277-82. 2007