Yoshio Shirai

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. ncbi Intraoperative assessment of the resectability of hilar cholangiocarcinoma
    Yoshio Shirai
    Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Hepatogastroenterology 59:2436-8. 2012
  2. pmc "Extended" radical cholecystectomy for gallbladder cancer: long-term outcomes, indications and limitations
    Yoshio Shirai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951 8510, Japan
    World J Gastroenterol 18:4736-43. 2012
  3. pmc Assessment of lymph node status in gallbladder cancer: location, number, or ratio of positive nodes
    Yoshio Shirai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City 951 8510, Japan
    World J Surg Oncol 10:87. 2012
  4. doi Full-thickness cholecystectomy with limited lymphadenectomy for gallbladder cancer
    Yoshio Shirai
    Niigata University, Niigata City, Japan
    Hepatogastroenterology 59:1338-40. 2012
  5. pmc Regional lymphadenectomy for gallbladder cancer: rational extent, technical details, and patient outcomes
    Yoshio Shirai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951 8510, Japan
    World J Gastroenterol 18:2775-83. 2012
  6. ncbi Radical lymph node dissection for gallbladder cancer: indications and limitations
    Yoshio Shirai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City, 951 8510 Japan
    Surg Oncol Clin N Am 16:221-32. 2007
  7. ncbi Clinical significance of lymph node micrometastasis in ampullary carcinoma
    Eiko Sakata
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City 951 8510, Japan
    World J Surg 30:985-91. 2006
  8. doi Assessment of the nodal status in ampullary carcinoma: the number of positive lymph nodes versus the lymph node ratio
    Jun Sakata
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata City, 951 8510, Japan
    World J Surg 35:2118-24. 2011
  9. doi Fucosylated fraction of alpha-fetoprotein as a predictor of prognosis in patients with hepatocellular carcinoma after curative treatment
    Yasushi Tamura
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata, Japan
    Dig Dis Sci 55:2095-101. 2010
  10. doi Overexpression of osteopontin independently correlates with vascular invasion and poor prognosis in patients with hepatocellular carcinoma
    Pavel V Korita
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951 8510, Japan
    Hum Pathol 39:1777-83. 2008

Collaborators

Detail Information

Publications80

  1. ncbi Intraoperative assessment of the resectability of hilar cholangiocarcinoma
    Yoshio Shirai
    Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Hepatogastroenterology 59:2436-8. 2012
    ..In conclusion, this simple technique, isolation of the right hepatic artery behind Calot's triangle before start-ing resection, should be applied to all hilar malignancies when a left-sided hepatectomy is planned...
  2. pmc "Extended" radical cholecystectomy for gallbladder cancer: long-term outcomes, indications and limitations
    Yoshio Shirai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951 8510, Japan
    World J Gastroenterol 18:4736-43. 2012
    ..To delineate indications and limitations for "extended" radical cholecystectomy for gallbladder cancer: a procedure which was instituted in our department in 1982...
  3. pmc Assessment of lymph node status in gallbladder cancer: location, number, or ratio of positive nodes
    Yoshio Shirai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City 951 8510, Japan
    World J Surg Oncol 10:87. 2012
    ..The aim of this study was to compare the anatomical location of positive nodes, number of positive nodes, and lymph node ratio (LNR) as prognostic predictors in gallbladder cancer...
  4. doi Full-thickness cholecystectomy with limited lymphadenectomy for gallbladder cancer
    Yoshio Shirai
    Niigata University, Niigata City, Japan
    Hepatogastroenterology 59:1338-40. 2012
    ..This less invasive procedure can be applied to patients with advanced age and/or comorbid disease(s), provided that the tumor is apparently confined to the gallbladder wall and has no gross evidence of distant metastases/nodal disease...
  5. pmc Regional lymphadenectomy for gallbladder cancer: rational extent, technical details, and patient outcomes
    Yoshio Shirai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951 8510, Japan
    World J Gastroenterol 18:2775-83. 2012
    ..To define the rational extent of regional lymphadenectomy for gallbladder cancer and to clarify its effect on long-term survival...
  6. ncbi Radical lymph node dissection for gallbladder cancer: indications and limitations
    Yoshio Shirai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City, 951 8510 Japan
    Surg Oncol Clin N Am 16:221-32. 2007
    ..Extended resection with extensive lymphadenectomy should be limited to expert surgeons because it may cause serious morbidity and mortality...
  7. ncbi Clinical significance of lymph node micrometastasis in ampullary carcinoma
    Eiko Sakata
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City 951 8510, Japan
    World J Surg 30:985-91. 2006
    ..This study aimed to clarify the clinical significance of lymph node micrometastasis in ampullary carcinoma...
  8. doi Assessment of the nodal status in ampullary carcinoma: the number of positive lymph nodes versus the lymph node ratio
    Jun Sakata
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata City, 951 8510, Japan
    World J Surg 35:2118-24. 2011
    ..This study was intended to compare the prognostic power of the number of positive lymph nodes with that of the lymph node ratio in patients with ampullary carcinoma...
  9. doi Fucosylated fraction of alpha-fetoprotein as a predictor of prognosis in patients with hepatocellular carcinoma after curative treatment
    Yasushi Tamura
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata, Japan
    Dig Dis Sci 55:2095-101. 2010
    ..The aim of this study was to evaluate the clinical usefulness of measuring the Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3) for prognostic predictor in patients with hepatocellular carcinoma (HCC)...
  10. doi Overexpression of osteopontin independently correlates with vascular invasion and poor prognosis in patients with hepatocellular carcinoma
    Pavel V Korita
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951 8510, Japan
    Hum Pathol 39:1777-83. 2008
    ..These results suggest that overexpression of osteopontin independently correlates with vascular invasion and thus predicts poor survival for patients with HCC, whereas aberrant expression of E-cadherin or beta-catenin does not...
  11. doi Appraisal of 1 cm hepatectomy margins for intrahepatic micrometastases in patients with colorectal carcinoma liver metastasis
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata City, 951 8510, Japan
    Ann Surg Oncol 15:2472-81. 2008
    ..This study sought to clarify the distribution of intrahepatic micrometastases and elucidate an adequate hepatectomy margin for colorectal carcinoma liver metastases...
  12. pmc Prognostic significance of NQO1 expression in intrahepatic cholangiocarcinoma
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences Niigata, Japan
    Int J Clin Exp Pathol 4:363-70. 2011
    ..001) and loss of NQO1 expression (p<0.001) had an independent adverse effect on survival. Loss of NQO1 expression reflects dedifferentiation and thus indicates a poor prognosis for patients undergoing resection for ICC...
  13. doi Risk of subsequent biliary malignancy in patients undergoing cyst excision for congenital choledochal cysts
    Taku Ohashi
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Gastroenterol Hepatol 28:243-7. 2013
    ..The aim of this study was to elucidate the risk of subsequent biliary malignancy in patients undergoing cyst excision for congenital choledochal cysts...
  14. ncbi Major hepatic resection reduces the probability of intrahepatic recurrences following resection of colorectal carcinoma liver metastases
    Shigenori Nagakura
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City, 951 8510 Japan
    Hepatogastroenterology 50:779-83. 2003
    ..The use of major versus limited hepatic resection for colorectal carcinoma liver metastases remains controversial. We evaluated the role of major hepatic resection in managing patients with colorectal carcinoma liver metastases...
  15. doi Loss of carcinoembryonic antigen-related cell adhesion molecule 1 expression predicts metachronous pulmonary metastasis and poor survival in patients with hepatoblastoma
    Mami Tsukada
    Division of Pediatric Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951 8510, Japan
    J Pediatr Surg 44:1522-8. 2009
    ..The aim of this study was to test the hypothesis that loss of CEACAM1 expression in hepatoblastoma cells may promote hematogeneous metastasis and function as an adverse prognostic factor...
  16. ncbi Intrahepatic lymphatic invasion independently predicts poor survival and recurrences after hepatectomy in patients with colorectal carcinoma liver metastases
    Pavel V Korita
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata City, 951 8510, Japan
    Ann Surg Oncol 14:3472-80. 2007
    ..We hypothesized that intrahepatic lymphatic invasion reflects the nodal status of colorectal carcinoma liver metastases and may function as an adverse prognostic factor...
  17. ncbi Catheter tract implantation metastases associated with percutaneous biliary drainage for extrahepatic cholangiocarcinoma
    Jun Sakata
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City 951 8510, Japan
    World J Gastroenterol 11:7024-7. 2005
    ....
  18. doi Reduced NKG2D ligand expression in hepatocellular carcinoma correlates with early recurrence
    Hiroteru Kamimura
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Hepatol 56:381-8. 2012
    ....
  19. doi Ribonucleotide reductase M1 expression in intrahepatic cholangiocarcinoma
    Toshifumi Wakai
    Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hepatogastroenterology 58:1659-63. 2011
    ....
  20. ncbi Clinical significance of intracapsular and extratumoral venous invasion in hepatocellular carcinoma
    Masanori Ohashi
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata City 951 8510, Japan
    Hepatogastroenterology 57:611-5. 2010
    ..The current study sought to clarify whether intracapsular venous invasion and extratumoral venous invasion confer different prognostic significance in patients undergoing hepatectomy for hepatocellular carcinoma...
  21. ncbi Loss of liver-intestine cadherin in human intrahepatic cholangiocarcinoma promotes angiogenesis by up-regulating metal-responsive transcription factor-1 and placental growth factor
    Masaaki Takamura
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachi dori 1, Chuo Ku, Niigata 951 8510, Japan
    Int J Oncol 36:245-54. 2010
    ..Loss of LI-cadherin results in up-regulation of MTF-1 and PlGF, thereby regulating angiogenesis in ICC...
  22. doi Preoperative cholangitis independently increases in-hospital mortality after combined major hepatic and bile duct resection for hilar cholangiocarcinoma
    Jun Sakata
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata, Japan
    Langenbecks Arch Surg 394:1065-72. 2009
    ..This study evaluated the impact of ductal bile bacteria (bactibilia or cholangitis) on the development of surgical site infection (SSI) or in-hospital mortality after resection for hilar cholangiocarcinoma...
  23. ncbi Surgical outcomes of minor hepatectomy for locally advanced gallbladder carcinoma
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hepatogastroenterology 59:2083-8. 2012
    ..This study aimed to evaluate whether wedge resection or S4bS5 resection was the more beneficial hepatectomy procedure for patients with locally advanced gallbladder carcinoma...
  24. ncbi Depth of subserosal invasion predicts long-term survival after resection in patients with T2 gallbladder carcinoma
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Ann Surg Oncol 10:447-54. 2003
    ..This study aimed to identify a subgroup of patients with inapparent T2 gallbladder carcinoma who may be best suited for radical second resection...
  25. ncbi Low preoperative platelet counts predict a high mortality after partial hepatectomy in patients with hepatocellular carcinoma
    Kazuhiro Kaneko
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Japan
    World J Gastroenterol 11:5888-92. 2005
    ....
  26. ncbi Hepatic lymph node dissection provides a survival benefit for patients with nodal disease of colorectal carcinoma liver metastases
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata City 951 8510, Japan
    Hepatogastroenterology 56:186-90. 2009
    ..This retrospective study aimed to define the role of hepatic lymph node dissection in the surgical management of patients with resectable colorectal carcinoma liver metastases...
  27. doi Depth of invasion determines the postresectional prognosis for patients with T1 extrahepatic cholangiocarcinoma
    Masayuki Nagahashi
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951 8510, Japan
    Cancer 116:400-5. 2010
    ....
  28. doi Histological evaluation of intracapsular venous invasion for discrimination between portal and hepatic venous invasion in hepatocellular carcinoma
    Masanori Ohashi
    Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Gastroenterol Hepatol 25:143-9. 2010
    ..Histological criteria for intracapsular venous invasion (IVI) that would allow its discrimination between portal and hepatic venous invasion in hepatocellular carcinoma (HCC) have not been established...
  29. ncbi Multidrug resistance-associated protein 2 determines the efficacy of cisplatin in patients with hepatocellular carcinoma
    Pavel V Korita
    Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
    Oncol Rep 23:965-72. 2010
    ..Expression of MRP2 determines the efficacy of cisplatin-based chemotherapy in patients with HCC...
  30. ncbi Impact of ductal resection margin status on long-term survival in patients undergoing resection for extrahepatic cholangiocarcinoma
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Cancer 103:1210-6. 2005
    ....
  31. ncbi Clinicopathological features of benign biliary strictures masquerading as biliary malignancy
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Am Surg 78:1388-91. 2012
    ..Although benign biliary strictures are rare, differentiating benign strictures from malignancy remains problematic. Thus, the treatment approach for biliary strictures should remain surgical resection for presumed biliary malignancy...
  32. pmc Histologic evaluation of intrahepatic micrometastases in patients treated with or without neoadjuvant chemotherapy for colorectal carcinoma liver metastasis
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Int J Clin Exp Pathol 5:308-14. 2012
    ..313 and p=0.526, respectively). In conclusion, NAC reduces the incidence of intrahepatic micrometastases in patients with CRLM, but NAC has no significant effect on their distribution when intrahepatic micrometastases are present...
  33. doi Liver-intestine cadherin in intraepithelial neoplasia of intrahepatic cholangiocarcinoma
    Makoto Inoue
    Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hepatogastroenterology 58:2045-51. 2011
    ..The aim of this study was to identify factors associated with LI-cadherin expression in biliary intraepithelial lesions of intrahepatic cholangiocarcinoma (ICC)...
  34. ncbi Anatomic resection independently improves long-term survival in patients with T1-T2 hepatocellular carcinoma
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City 951 8510, Japan
    Ann Surg Oncol 14:1356-65. 2007
    ..This study aimed to evaluate the effect of anatomic resection on long-term outcomes in patients with pathologic T1-T2 (pT1-T2) hepatocellular carcinoma...
  35. ncbi Jaundice at presentation heralds advanced disease and poor prognosis in patients with ampullary carcinoma
    Naoyuki Yokoyama
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi dori 1 757, Niigata, 951 8510, Japan
    World J Surg 29:519-23. 2005
    ..0014). In conclusion, jaundice at presentation predicts advanced-stage ampullary carcinoma and a poor prognosis. Pancreatic invasion and superior mesenteric nodal involvement were not observed in nonjaundiced patients...
  36. doi Mode of hepatic spread from gallbladder carcinoma: an immunohistochemical analysis of 42 hepatectomized specimens
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Am J Surg Pathol 34:65-74. 2010
    ..The mode of hepatic spread independently predicts long-term survival after resection for patients with gallbladder carcinoma. Hepatic metastatic nodules indicate a dismal outcome after resection...
  37. doi Alteration of p53-binding protein 1 expression as a risk factor for local recurrence in patients undergoing resection for extrahepatic cholangiocarcinoma
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
    Int J Oncol 38:1227-36. 2011
    ..0% at 5 years; P=0.020). In conclusion, after resection for extrahepatic cholangiocarcinoma, clinically evident local recurrence at ductal stumps is closely associated with 53BP1 inactivation and decreased apoptosis...
  38. ncbi Intraepithelial ductal spread in colorectal carcinoma liver metastasis
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata, Japan
    Hepatogastroenterology 58:583-8. 2011
    ..This study aimed to evaluate the usefulness of immunohistochemical combinations for discrimination between intraepithelial ductal spread of colorectal carcinoma liver metastasis (CRLM) and that of intrahepatic cholangiocarcinoma (ICC)...
  39. ncbi FK506 may reduce early liver injury following living related liver transplantation
    Takashi Kato
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Science Niigata, Japan
    Hepatogastroenterology 53:580-3. 2006
    ....
  40. ncbi Adenosquamous carcinoma of the gallbladder warrants resection only if curative resection is feasible
    Yasuhiro Oohashi
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Cancer 94:3000-5. 2002
    ..The objective of this study was to clarify the effectiveness of resection for patients with adenosquamous/squamous cell carcinoma of the gallbladder...
  41. ncbi Aberrant expression of vimentin correlates with dedifferentiation and poor prognosis in patients with intrahepatic cholangiocarcinoma
    Pavel V Korita
    Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
    Anticancer Res 30:2279-85. 2010
    ..This study aimed to elucidate the prognostic value of vimentin expression in patients with intrahepatic cholangiocarcinoma (ICC)...
  42. doi Number of positive lymph nodes independently determines the prognosis after resection in patients with gallbladder carcinoma
    Jun Sakata
    Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Ann Surg Oncol 17:1831-40. 2010
    ..This study was designed to compare the prognostic power of the location of positive lymph nodes with that of the number of positive lymph nodes in gallbladder carcinoma...
  43. ncbi Perimuscular connective tissue contains more and larger lymphatic vessels than the shallower layers in human gallbladders
    Masayuki Nagahashi
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City, Japan
    World J Gastroenterol 13:4480-3. 2007
    ..To clarify whether perimuscular connective tissue contains more lymphatic vessels than the shallower layers in human gallbladders...
  44. ncbi Long-term outcomes of hepatectomy vs percutaneous ablation for treatment of hepatocellular carcinoma < or =4 cm
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    World J Gastroenterol 12:546-52. 2006
    ..To determine which treatment modality--hepatectomy or percutaneous ablation--is more beneficial for patients with small hepatocellular carcinoma (HCC) (< or =4 cm) in terms of long-term outcomes...
  45. doi Combined major hepatectomy and pancreaticoduodenectomy for locally advanced biliary carcinoma: long-term results
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
    World J Surg 32:1067-74. 2008
    ..This study aimed to define the role of combined major hepatectomy and pancreaticoduodenectomy in the surgical management of biliary carcinoma and to identify potential candidates for this aggressive procedure...
  46. ncbi Narrow portion of the terminal choledochus is a cause of upstream biliary dilatation in patients with anomalous union of the pancreatic and biliary ducts
    Tatsuya Nomura
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 Asahimachi dori, Niigata, 951 8510, Japan
    World J Gastroenterol 11:6503-7. 2005
    ..To clarify the pathogenesis of biliary dilatation associated with anomalous union of the pancreatic and biliary ducts (AUPBD)...
  47. doi Morphological features of early gallbladder carcinoma
    Toshifumi Wakai
    Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hepatogastroenterology 59:1013-7. 2012
    ..This study aimed to clarify the morphological features of early gallbladder carcinoma including tumors invading the lamina propria (pT1a) or muscular layer (pT1b)...
  48. ncbi Radical second resection provides survival benefit for patients with T2 gallbladder carcinoma first discovered after laparoscopic cholecystectomy
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City, 951 8510, Japan
    World J Surg 26:867-71. 2002
    ..Radical second resection may be beneficial for patients with pT2 gallbladder carcinoma first discovered after laparoscopic cholecystectomy...
  49. doi Progression of hypermethylation of the p16(INK4A) gene from normal liver to nontumorous liver and hepatocellular carcinoma: an evaluation using quantitative PCR analysis
    So Kurita
    Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences of Niigata University, 1 754, Asahimachi Dori, Niigata City, 951 8122, Japan
    Dig Dis Sci 54:80-8. 2009
    ..There may be a greater proportion of cells which contain methylated p16 in nontumorous than in normal liver. However, the difference was so small that the functional relevance to hepatocarcinogenesis remains elusive...
  50. ncbi Humoral hypercalcemia complicating adenocarcinoma of the sigmoid colon: report of a case
    Jun Sakata
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Surg Today 35:692-5. 2005
    ....
  51. doi Surgical outcomes for hepatocellular carcinoma in nonalcoholic fatty liver disease
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, 951 8510, Japan
    J Gastrointest Surg 15:1450-8. 2011
    ..The present study investigated outcomes following surgical resection of hepatocellular carcinoma (HCC) in nonalcoholic fatty liver disease (NAFLD)...
  52. ncbi Tumor suppressor carcinoembryonic antigen-related cell adhesion molecule 1 potentates the anchorage-independent growth of human hepatoma HepG2 cells
    Mariko Hokari
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi dori 1 757, Niigata 951 8510, Japan
    Life Sci 81:336-45. 2007
    ....
  53. ncbi An 11-year survivor who underwent ten sequential resections of colonic adenocarcinoma metastases
    Shigenori Nagakura
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City, 951 8510 Japan
    Hepatogastroenterology 50:1032-3. 2003
    ..Surgeons should pursue resection for colorectal carcinoma metastases, regardless of frequent operations and sites involved, as reliable medical treatment remains unestablished...
  54. doi Early DNA damage response in residual carcinoma in situ at ductal stumps and local recurrence in patients undergoing resection for extrahepatic cholangiocarcinoma
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata, 951 8510, Japan
    J Hepatobiliary Pancreat Sci 20:362-9. 2013
    ....
  55. ncbi Aberrant expression of pRb and p16(INK4), alone or in combination, indicates poor outcome after resection in patients with colorectal carcinoma
    Xing Cui
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Hum Pathol 35:1189-95. 2004
    ..994, P <0.0001, respectively). Most CRCs demonstrate aberrant expression of pRb and/or p16 at resectable stages. Aberrant expression of pRb and p16, alone and in combination, heralds poor prognosis in patients with CRC...
  56. ncbi Increased risk of cholelithiasis after esophagectomy
    Kazuhiko Tsunoda
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, 951 8510, Niigata, Japan
    J Hepatobiliary Pancreat Surg 11:319-23. 2004
    ..This study was intended to test this hypothesis and to elucidate factors influencing the incidence of cholelithiasis after esophagectomy...
  57. ncbi Long-term survival after resection of colonic adenocarcinoma with synchronous metastases to the liver, adrenal gland, and aortic-caval lymph nodes: report of a case
    Shigenori Nagakura
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Dis Colon Rectum 45:1679-80. 2002
  58. pmc Genetic changes of p53, K-ras, and microsatellite instability in gallbladder carcinoma in high-incidence areas of Japan and Hungary
    Masayuki Nagahashi
    Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
    World J Gastroenterol 14:70-5. 2008
    ..To disclose geographic differences in genetic changes involved in gallbladder carcinogenesis between two distinct high-incidence areas of Japan and Hungary...
  59. ncbi Loss of carcinoembryonic antigen-related cell adhesion molecule 1 expression is an adverse prognostic factor in hepatocellular carcinoma
    Pauldion V Cruz
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Cancer 104:354-60. 2005
    ..The authors hypothesized that loss of CEACAM1 expression in hepatocellular carcinoma (HCC) cells may function as an adverse prognostic factor...
  60. ncbi Gallbladder carcinoma presenting as exfoliative dermatitis (erythroderma)
    Hitoshi Kameyama
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Int J Gastrointest Cancer 35:153-5. 2005
    ..The experience of the current patient suggests that erythroderma secondary to GI malignancy may resolve spontaneously after curative resection of the tumor...
  61. ncbi Peroral cholangioscopy for non-invasive papillary cholangiocarcinoma with extensive superficial ductal spread
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, Niigata 951 8510, Japan
    World J Gastroenterol 11:6554-6. 2005
    ....
  62. ncbi Dynamic computed tomography findings of malignant intraductal papillary mucinous tumor compared with invasive ductal adenocarcinoma
    Toshiro Ozaki
    Department of Radiation Oncology, Niigata Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Radiat Med 25:446-52. 2007
    ..We evaluated the effectiveness of dynamic computed tomography (CT) imaging in differentiating malignant intraductal papillary mucinous tumor (IPMT) with a large mural nodule from invasive ductal adenocarcinoma (IDAC)...
  63. ncbi Treatment of a case with right-sided diaphragmatic hernia associated with an abnormal vessel communication between a herniated liver and the right lung
    Shinji Tanaka
    Department of Pediatric Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
    J Pediatr Surg 41:e25-8. 2006
    ..When performing surgery on a right-sided diaphragmatic hernia, the potential presence of such a vessel anomaly should be carefully taken into consideration...
  64. ncbi Segmental adenomyomatosis of the gallbladder predisposes to cholecystolithiasis
    Atsushi Nishimura
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, 951 8510, Niigata, Japan
    J Hepatobiliary Pancreat Surg 11:342-7. 2004
    ..The aim of the present study was to clarify the association between adenomyomatosis of the gallbladder and cholecystolithiasis...
  65. ncbi Hemangiopericytoma arising in the greater omentum: report of a case
    Kazuhiro Kaneko
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Surg Today 33:722-4. 2003
    ..A review of the reported cases suggests that surgical resection provides the only chance of cure and that a high mitotic index (>4/10 high-power fields) and a tumor size of > or =20 cm predict an unfavorable prognosis after resection...
  66. pmc Synchronous development of HCC and CCC in the same subsegment of the liver in a patient with type C liver cirrhosis
    Takuya Watanabe
    Takuya Watanabe, Haruka Hirono, Katsuhiko Hasegawa, Kenji Soga, Koichi Shibasaki, Department of Internal Medicine and Gastroenterology, Medical Hospital, The Nippon Dental University School of Life Dentistry at Niigata, 1 8, Hamauracho, Chuo Ku, Niigata 951 8580, Japan
    World J Hepatol 1:103-9. 2009
    ..We also add a literature review for all the reported cases published in Japan and around the world, and summarize the features of double cancer exhibiting both HCC and CCC...
  67. ncbi Postoperative management for donor safety in living related donor liver transplantation
    Yoshinobu Sato
    First Department of Surgery, School of Medicine, Niigata University, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Hepatogastroenterology 50:196-200. 2003
    ..In this study, we investigated the utility of prostaglandin E1, methylprednisolone and C-tube in the postoperative management for donor operation based on our understanding of the mechanisms of liver injury after massive hepatectomy...
  68. ncbi Prevalence of cholesterol gallstones positively correlates with per capita daily calorie intake
    Kazuhiko Tsunoda
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Hepatogastroenterology 51:1271-4. 2004
    ..This trend is possibly due to the westernization of dietary habits. This study was undertaken to delineate the changing trends in gallstone composition in Japan since the 1920s and to assess dietary influences on gallstone composition...
  69. ncbi Immunohistochemically detected hepatic micrometastases predict a high risk of intrahepatic recurrence after resection of colorectal carcinoma liver metastases
    Naoyuki Yokoyama
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Cancer 94:1642-7. 2002
    ..The objectives of the current study were to assess the feasibility of the immunohistochemical detection of hepatic micrometastases from colorectal carcinoma and to determine their clinical significance...
  70. ncbi [Pharmacokinetic modulating chemotherapy highly effective for colorectal carcinoma metastases to multiple organs]
    Katsuki Muneoka
    Dept of Surgery, Niitsu Medical Center Hospital, Niigata University Graduate School of Medical and Dental Sciences
    Gan To Kagaku Ryoho 32:799-802. 2005
    ..The therapeutic efficacy of PMC and the sensitivity of metastatic lesions to 5-FU were evaluated in advanced colorectal cancer patients...
  71. ncbi Multiple repeat resections of intra- and extrahepatic recurrences in patients undergoing initial hepatectomy for colorectal carcinoma metastases
    Shigenori Nagakura
    Department of Surgery, Niigata University School of Medicine, 1 757 Asahimachi dori, Niigata City 951 8510, Japan
    World J Surg 26:141-7. 2002
    ..Repeat resection should be considered for any resectable recurrences after hepatectomy...
  72. ncbi [Second-line chemotherapy with pharmacokinetic modulating chemotherapy for unresectable colorectal carcinoma recurrences resistant to 5-FU-based chemotherapy]
    Katsuki Muneoka
    Dept of Surgery, Niitsu Medical Center Hospital
    Gan To Kagaku Ryoho 33:779-82. 2006
    ..The aim of this study was to evaluate the efficacy of PMC as a second-line chemotherapy for postresectional recurrences of colorectal carcinoma...
  73. ncbi [Pharmacokinetic modulating chemotherapy for rectal carcinoma metastases to the liver and lung--a case report]
    Katsuki Muneoka
    Dept of Surgery, Niitsu Medical Center Hospital
    Gan To Kagaku Ryoho 32:231-3. 2005
    ..The high serum 5-FU concentrations at night suggest the chronomodulating nature of PMC and are effective for metastatic colorectal carcinoma...
  74. ncbi Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cells
    Xing Cui
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305 8506, Japan
    Hum Pathol 37:298-311. 2006
    ..In conclusion, a low concentration of As2O3 induces CpG island demethylation of tumor suppressor genes by inhibition of DNMT and reactivates the partially/fully silenced genes in liver cancer cells...
  75. ncbi [Irinotecan plus gemcitabine(IRINOGEM)in the treatment of biliary malignancies]
    Katsuki Muneoka
    Depts of Surgery, Niitsu Medical Center Hospital
    Gan To Kagaku Ryoho 35:61-4. 2008
    ..The present study was conducted to evaluate the effects of irinotecan plus gemcitabine(IRINOGEM)on biliary malignancies...
  76. ncbi 5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine
    Katsuki Muneoka
    Department of Surgery, Niitsu Medical Center Hospital, Niigata, Japan
    Int J Clin Oncol 10:441-3. 2005
    ..The experience of this case, together with a review of the literature, suggests that FBAL is related to 5-FU-induced cardiotoxicity. S-1 may be administered safely to patients with 5-FU-induced cardiotoxicity...
  77. ncbi Chronic oral exposure to inorganic arsenate interferes with methylation status of p16INK4a and RASSF1A and induces lung cancer in A/J mice
    Xing Cui
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305 8506, Japan
    Toxicol Sci 91:372-81. 2006
    ..In conclusion, iAs(V) exposure increased lung tumor incidence and multiplicity in A/J mice. Epigenetic changes of tumor suppressor genes such as p16INK4a and RASSF1A are involved in the iAs(V)-induced lung carcinogenesis...
  78. ncbi [Surgical therapy for colorectal neoplasms--surgical removal of hepatic metastases and rectal neoplasms]
    Tsuneo Iiai
    Nihon Naika Gakkai Zasshi 96:277-82. 2007
  79. ncbi Two-step hepatectomy using right portal vein ligation for multiple bilobar hepatocellular carcinomas arising in injured liver
    Toshifumi Wakai
    Surgery 137:124. 2005
  80. ncbi Liver regeneration enhanced by orally administered ursodesoxycholic acid is mediated by immunosuppression in partially hepatectomized rats
    Lili Liu
    The First Department of Surgery, Niigata University School of Medicine, Japan
    Am J Chin Med 30:119-26. 2002
    ..It was also noted that UDCA did not affect serum parameters indicating liver and kidney function. These findings suggest that liver regeneration can be modified by orally administered UDCA through a change in immunoactivity...