Takashi Saku

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. doi request reprint Keratin 10-positive orthokeratotic dysplasia: a new leucoplakia-type precancerous entity of the oral mucosa
    Takanori Kobayashi
    Oral Pathology Section, Department of Surgical Pathology, Niigata University Hospital, Niigata, Japan
    Histopathology 61:910-20. 2012
  2. pmc Establishment and characterization of pleomorphic adenoma cell systems: an in-vitro demonstration of carcinomas arising secondarily from adenomas in the salivary gland
    Satoshi Maruyama
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University, Graduate School of Medical and Dental Sciences, 2 5274 Gakkoucho dori, Chuo Ku, Niigata 951 8514, Japan
    BMC Cancer 9:247. 2009
  3. doi request reprint Differential expression of perlecan receptors, α-dystroglycan and integrin β1, before and after invasion of oral squamous cell carcinoma
    Md Shahidul Ahsan
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Oral Pathol Med 40:552-9. 2011
  4. doi request reprint Podoplanin-mediated cell adhesion through extracellular matrix in oral squamous cell carcinoma
    Masayuki Tsuneki
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Lab Invest 93:921-32. 2013
  5. doi request reprint Intramuscular keratocyst as a soft tissue counterpart of keratocystic odontogenic tumor: differential diagnosis by immunohistochemistry
    Tatsuya Abe
    Oral Pathology Section, Department of Surgical Pathology, Niigata University Hospital, Niigata 951 8520, Japan Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8514, Japan
    Hum Pathol 45:110-8. 2014
  6. doi request reprint Diagnostic value of integrin alpha3, beta4, and beta5 gene expression levels for the clinical outcome of tongue squamous cell carcinoma
    Akira Kurokawa
    Division of Oral and Maxillofacial Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Cancer 112:1272-81. 2008
  7. doi request reprint Histopathological varieties of oral carcinoma in situ: Diagnosis aided by immunohistochemistry dealing with the second basal cell layer as the proliferating center of oral mucosal epithelia
    Takanori Kobayashi
    Surgical Pathology Section, Niigata University Hospital, Divisions of Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, 2 5274 Gakkocho dori, Chuo Ku, Niigata 851 8514, Japan
    Pathol Int 60:156-66. 2010
  8. ncbi request reprint Two-phase appearance of oral epithelial dysplasia resulting from focal proliferation of parabasal cells and apoptosis of prickle cells
    Mei Syafriadi
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Oral Pathol Med 34:140-9. 2005
  9. doi request reprint Differential expression profiles between α-dystroglycan and integrin β1 in ameloblastoma: two possible perlecan signalling pathways for cellular growth and differentiation
    Hiroko Ida-Yonemochi
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Histopathology 58:234-45. 2011
  10. doi request reprint Emergence of keratin 17 vs. loss of keratin 13: their reciprocal immunohistochemical profiles in oral carcinoma in situ
    Toshihiko Mikami
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Oral Oncol 47:497-503. 2011

Collaborators

Detail Information

Publications31

  1. doi request reprint Keratin 10-positive orthokeratotic dysplasia: a new leucoplakia-type precancerous entity of the oral mucosa
    Takanori Kobayashi
    Oral Pathology Section, Department of Surgical Pathology, Niigata University Hospital, Niigata, Japan
    Histopathology 61:910-20. 2012
    ..We investigated a group of oral mucosal lesions with characteristic hyperorthokeratotic foci, which we termed orthokeratotic dysplasia (OKD), to determine if it could be identified as a distinct histopathological entity...
  2. pmc Establishment and characterization of pleomorphic adenoma cell systems: an in-vitro demonstration of carcinomas arising secondarily from adenomas in the salivary gland
    Satoshi Maruyama
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University, Graduate School of Medical and Dental Sciences, 2 5274 Gakkoucho dori, Chuo Ku, Niigata 951 8514, Japan
    BMC Cancer 9:247. 2009
    ..It is still poorly understood how and which benign pleomorphic adenoma cells transform into its malignant form, carcinoma ex pleomorphic adenoma...
  3. doi request reprint Differential expression of perlecan receptors, α-dystroglycan and integrin β1, before and after invasion of oral squamous cell carcinoma
    Md Shahidul Ahsan
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Oral Pathol Med 40:552-9. 2011
    ..Because α-dystroglycan and integrin β1 have been identified as two of the perlecan receptors, we wanted to determine their differential distributions before and after invasion of oral SCC...
  4. doi request reprint Podoplanin-mediated cell adhesion through extracellular matrix in oral squamous cell carcinoma
    Masayuki Tsuneki
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Lab Invest 93:921-32. 2013
    ..There was no siRNA effect in migration. We have demonstrated the primary function of PDPN in cell adhesion to ECM, which is to secondarily promote oral SCC cell proliferation. ..
  5. doi request reprint Intramuscular keratocyst as a soft tissue counterpart of keratocystic odontogenic tumor: differential diagnosis by immunohistochemistry
    Tatsuya Abe
    Oral Pathology Section, Department of Surgical Pathology, Niigata University Hospital, Niigata 951 8520, Japan Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8514, Japan
    Hum Pathol 45:110-8. 2014
    ..The results indicate that KCOT-like lesions can arise within soft tissues, although use of the term odontogenic might seem inappropriate in those cases. ..
  6. doi request reprint Diagnostic value of integrin alpha3, beta4, and beta5 gene expression levels for the clinical outcome of tongue squamous cell carcinoma
    Akira Kurokawa
    Division of Oral and Maxillofacial Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Cancer 112:1272-81. 2008
    ..The objective of the current study was to identify biomarkers that reflect the clinical course of squamous cell carcinoma of the tongue (TSCC)...
  7. doi request reprint Histopathological varieties of oral carcinoma in situ: Diagnosis aided by immunohistochemistry dealing with the second basal cell layer as the proliferating center of oral mucosal epithelia
    Takanori Kobayashi
    Surgical Pathology Section, Niigata University Hospital, Divisions of Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, 2 5274 Gakkocho dori, Chuo Ku, Niigata 851 8514, Japan
    Pathol Int 60:156-66. 2010
    ..The results indicate that oral CIS contain more histological variations, especially those with definite keratinization, than what had been previously defined...
  8. ncbi request reprint Two-phase appearance of oral epithelial dysplasia resulting from focal proliferation of parabasal cells and apoptosis of prickle cells
    Mei Syafriadi
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Oral Pathol Med 34:140-9. 2005
    ..These basaloid cells are suddenly changed into an overlay of parakeratotic cells. However, it is unknown how this characteristic two-phase appearance is generated...
  9. doi request reprint Differential expression profiles between α-dystroglycan and integrin β1 in ameloblastoma: two possible perlecan signalling pathways for cellular growth and differentiation
    Hiroko Ida-Yonemochi
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Histopathology 58:234-45. 2011
    ..The aims of this study were to elucidate which types of perlecan receptors function within any particular type of tissue architecture of ameloblastoma...
  10. doi request reprint Emergence of keratin 17 vs. loss of keratin 13: their reciprocal immunohistochemical profiles in oral carcinoma in situ
    Toshihiko Mikami
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Oral Oncol 47:497-503. 2011
    ..The results indicate that expressions of K17 and K13 are reciprocal in oral epithelial lesions and that the K17 emergence is related to malignancies...
  11. doi request reprint Loss of keratin 13 in oral carcinoma in situ: a comparative study of protein and gene expression levels using paraffin sections
    Hiroko Ida-Yonemochi
    Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Mod Pathol 25:784-94. 2012
    ..The results suggest that the loss of K13 is partly due to its gene repression, but may also be due to some unknown post-translational events...
  12. doi request reprint Hemophagocytosis-mediated keratinization in oral carcinoma in situ and squamous cell carcinoma: a possible histopathogenesis of keratin pearls
    Kamal Al-Eryani
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata, Japan
    J Cell Physiol 228:1977-88. 2013
    ..Thus, hemorrhage from the rupture of blood vessels can be one of the triggers for keratin pearl formation in oral CIS and SCC...
  13. doi request reprint Extracellular heat shock protein A9 is a novel interaction partner of podoplanin in oral squamous cell carcinoma cells
    Masayuki Tsuneki
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Biochem Biophys Res Commun 434:124-30. 2013
    ..In conclusion, the results indicate that HSPA9 secreted by oral SCC cells interacts with PDPN on their cell surface in an autocrine manner and regulates their growth and invasiveness...
  14. doi request reprint Perlecan-rich epithelial linings as a background of proliferative potentials of keratocystic odontogenic tumor
    Masayuki Tsuneki
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Oral Pathol Med 37:287-93. 2008
    ....
  15. ncbi request reprint Hybrid ameloblastoma and adenomatoid odontogenic tumor: report of a case and review of hybrid variations in the literature
    Manabu Yamazaki
    Assistant Professor, Division of Oral Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol 118:e12-8. 2014
    ..This, however, is the first report of a hybrid tumor containing an authentic solid-type ameloblastoma compartment and an AOT compartment in a patient with a background of familial adenomatous polyposis. ..
  16. doi request reprint Ghost cell odontogenic carcinoma arising in the background of a benign calcifying cystic odontogenic tumor of the mandible
    Takaroni Arashiyama
    Division of Oral and Maxillofacial Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol 114:e35-40. 2012
    ..3 years, 22 (73%) involved the maxilla. Twelve (40%) were secondary malignant manifestations of benign CCOTs or dentinogenic ghost cell tumors. Five patients died of recurrence or distant metastasis...
  17. doi request reprint Keratinocyte growth factor colocalized with perlecan at the site of capsular invasion and vascular involvement in salivary pleomorphic adenomas
    Satoshi Maruyama
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Oral Pathol Med 38:377-85. 2009
    ..In this study, our aim was to elucidate the mode and the frequency of capsular invasion in this tumor and to characterize the tumor cell arrangement at the site of capsular invasion...
  18. doi request reprint Combined immunohistochemistry for the differential diagnosis of cystic jaw lesions: its practical use in surgical pathology
    Masayuki Tsuneki
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Histopathology 57:806-13. 2010
    ..The aim of this study was to seek practical measures to differentiate such lesions...
  19. ncbi request reprint Angiolipoma of the buccal mucosa: a possible role of mast cell-derived VEGF in its enhanced vascularity
    Hiroko Ida-Yonemochi
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Oral Pathol Med 34:59-61. 2005
    ....
  20. doi request reprint Podoplanin expression profiles characteristic of odontogenic tumor-specific tissue architectures
    Masayuki Tsuneki
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Pathol Res Pract 208:140-6. 2012
    ..In conclusion, podoplanin+ cells and areas in odontogenic tumors are in close associations with extracellular matrix signalings as well as cell proliferation...
  21. ncbi request reprint Reciprocal expressions between α-dystroglycan and integrin β1, perlecan receptors, in the murine enamel organ development
    Hiroko Ida-Yonemochi
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan Division of Anatomy and Cell Biology of the Hard Tissue, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Gene Expr Patterns 13:293-302. 2013
    ....
  22. ncbi request reprint Establishment and characterization of new cell lines derived from melanotic neuroectodermal tumor of infancy arising in the mandible
    Hamdy Metwaly
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Pathol Int 55:331-42. 2005
    ..The established cell systems will be useful for further investigation on the molecular and genetic basis of MNTI to understand its pathogenesis, which is largely unknown...
  23. ncbi request reprint Intraepithelial expression of perlecan, a basement membrane-type heparan sulfate proteoglycan reflects dysplastic changes of the oral mucosal epithelium
    Terué Ikarashi
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Oral Pathol Med 33:87-95. 2004
    ..Although enlargement of the intercellular space is one of the histological characteristics of epithelial dysplasia of oral mucosa, the mode of expression of perlecan is poorly understood in these epithelial lesions...
  24. ncbi request reprint Angiogenesis in mucous retention cyst: a human in vivo-like model of endothelial cell differentiation in mucous substrate
    Wael Swelam
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Oral Pathol Med 34:30-8. 2005
    ..Mucous retention cysts contain a mucous pool in the lumina, in which pure angiogenic processes are occasionally observed. By using this unique human material, our aim was to understand the in vivo angiogenic process...
  25. ncbi request reprint Nucleotide sequences and functions of the Epstein-Barr virus latent membrane protein 1 genes isolated from salivary gland lymphoepithelial carcinomas
    Kai Yu Jen
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, 951 8510, Japan
    Virus Genes 30:223-35. 2005
    ....
  26. ncbi request reprint Recruitment of osteoclasts in the mandible of osteopetrotic (op/op) mice
    Hiroko Ida-Yonemochi
    Department of Oral Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Eur J Oral Sci 112:148-55. 2004
    ..These findings suggest that osteoclasts are recruited in an M-CSF-independent manner in op/op mandibles, especially in areas around tooth germs...
  27. ncbi request reprint Epstein-Barr virus infected lymphoepithelial carcinomas of the salivary gland in the Russia-Asia area: a clinicopathologic study of 160 cases
    Takashi Saku
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Arkh Patol 65:35-9. 2003
    ..The results indicated that EBV infection and certain geographic factors play important roles in the pathogenesis of the salivary LEC...
  28. ncbi request reprint Identification of potential biomarkers of lymph node metastasis in oral squamous cell carcinoma by cDNA microarray analysis
    Masaki Nagata
    Division of Oral and Maxillofacial Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Int J Cancer 106:683-9. 2003
    ....
  29. ncbi request reprint Maxillary odontogenic keratocyst with respiratory epithelium: a case report
    Manabu Yamazaki
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Oral Pathol Med 32:496-8. 2003
    ..The impacted tooth was malformed lacking a root portion. We discuss the frequency of respiratory epithelium in odontogenic keratocysts...
  30. ncbi request reprint Sebaceous lymphadenoma of the lip: report of a case of minor salivary gland origin
    Satoshi Maruyama
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Oral Pathol Med 31:242-3. 2002
    ..This is the first case report of sebaceous lymphadenoma of minor salivary gland origin...
  31. ncbi request reprint Jaw bone remodeling at the invasion front of gingival squamous cell carcinomas
    Masahiro Ito
    Division of Reconstructive Surgery for Oral and Maxillofacial Region, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Oral Pathol Med 32:10-7. 2003
    ..It is still unknown how jaw bone remodeling occurs at actual invasion sites of oral squamous cell carcinomas. Since there is no other human carcinomas which make a direct invasion of the bone, gingival carcinomas are valuable examples...