Research Topics
| N OtsukaSummaryAffiliation: Niigata University Country: Japan Publications
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Detail Information
Publications
CAG repeat disorder models and human neuropathology: similarities and differencesMitsunori Yamada
Department of Pathology, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata, 951 8585, Japan
Acta Neuropathol 115:71-86. 2008....
Ultrastructural localization of CD38 immunoreactivity in rat brainM Yamada
Department of Pathology, Brain Research Institute, Niigata University, Asahimachi 1, Japan
Brain Res 756:52-60. 1997..Oligodendrocytes and microglia were immunonegative for CD38. The pattern of distribution of CD38 in the CNS is suggestive of multiple roles for this molecule at various functional sites in both neurons and astrocytes...
Polyglutamine disease: recent advances in the neuropathology of dentatorubral-pallidoluysian atrophyMitsunori Yamada
Department of Pathology, Brain Research Institute, Niigata University, Japan
Neuropathology 26:346-51. 2006..Polyglutamine diseases have a similarity with neuronal storage disease, and this pathological process might become a target for the establishment of an effective therapy for these diseases...
Sharing of polyglutamine localization by the neuronal nucleus and cytoplasm in CAG-repeat diseasesM Yamada
Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan
Neuropathol Appl Neurobiol 30:665-75. 2004....
Genotype-phenotype correlation in CAG-repeat diseasesMitsunori Yamada
Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan
Neuropathology 22:317-22. 2002..This novel pathology may become a clue for elucidating molecular mechanisms of neuronal dysfunction and establishing clinicopathological correlations in CAG-repeat diseases...
Oligodendrocytic polyglutamine pathology in dentatorubral-pallidoluysian atrophyMitsunori Yamada
Department of Pathology, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951 8585, Japan
Ann Neurol 52:670-4. 2002..These findings suggest that glial cells in dentatorubral-pallidoluysian atrophy also are involved in the polyglutamine pathogenesis...
Involvement of lysosomes in the pathogenesis of CAG repeat diseasesMitsunori Yamada
Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan
Ann Neurol 52:498-503. 2002....
Interaction between neuronal intranuclear inclusions and promyelocytic leukemia protein nuclear and coiled bodies in CAG repeat diseasesM Yamada
Departments of Pathology, Brain Research Institute, Niigata University, Niigata, Japan
Am J Pathol 159:1785-95. 2001..The results suggest that the interaction between NIIs and nuclear bodies may play a role in the pathogenesis of CAG repeat diseases...
Involvement of the cerebral cortex and autonomic ganglia in Machado-Joseph diseaseM Yamada
Department of Pathology, Brain Research Institute, Niigata University, Japan
Acta Neuropathol 101:140-4. 2001..These lesions, newly recognized by polyglutamine immunohistochemistry, may be responsible for the cerebral cortical dysfunctions or autonomic abnormalities pointed out in MJD patients by the recent clinical and neuroradiological studies...
Pathology of CAG repeat diseasesM Yamada
Department of Pathology, Brain Research Institute, Niigata University, Japan
Neuropathology 20:319-25. 2000....
Widespread occurrence of intranuclear atrophin-1 accumulation in the central nervous system neurons of patients with dentatorubral-pallidoluysian atrophyM Yamada
Department of Pathology, Brain Research Institute, Niigata University, Japan
Ann Neurol 49:14-23. 2001....
Ubiquitinated filamentous inclusions in cerebellar dentate nucleus neurons in dentatorubral-pallidoluysian atrophy contain expanded polyglutamine stretchesM Yamada
Department of Pathology, Niigata University, Japan
Acta Neuropathol 99:615-8. 2000....
Localization of Bcl-xbeta in the developing and adult rat central nervous systemM Yamada
Department of Pathology, Brain Research Institute, Niigata University, Asahimachi 1, Niigata, Japan
J Neurosci Res 60:468-77. 2000..These results suggest that Bcl-xbeta plays an important role throughout the CNS in developing stage and may regulate the apoptosis of postnatal CNS neurons...
Separate CNS lesions involving the brainstem and spinal cord in a 47-year-old manMitsunori Yamada
Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan
Neuropathology 28:341-4. 2008
