K Okuizumi

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. ncbi request reprint Apolipoprotein E epsilon4 allele and progression of cortical Lewy body pathology in Parkinson's disease
    K Wakabayashi
    Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
    Acta Neuropathol 95:450-4. 1998
  2. ncbi request reprint Accumulation of alpha-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy
    K Wakabayashi
    Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
    Acta Neuropathol 96:445-52. 1998
  3. ncbi request reprint Autosomal dominant diffuse Lewy body disease
    K Wakabayashi
    Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
    Acta Neuropathol 96:207-10. 1998
  4. ncbi request reprint Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy
    K Wakabayashi
    Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
    Neurosci Lett 249:180-2. 1998
  5. ncbi request reprint NACP/alpha-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson's disease brains
    K Wakabayashi
    Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
    Acta Neuropathol 99:14-20. 2000
  6. ncbi request reprint Sporadic motor neuron disease with severe sensory neuronopathy
    K Wakabayashi
    Brain Disease Research Center, Brain Research Institute, Niigata University, Asahimachi, Japan
    Acta Neuropathol 95:426-30. 1998
  7. ncbi request reprint Multiple system atrophy with severe involvement of the motor cortical areas and cerebral white matter
    K Wakabayashi
    Brain Disease Research Centre, Brain Research Institute, Niigata University, Japan
    J Neurol Sci 156:114-7. 1998
  8. ncbi request reprint NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease
    K Wakabayashi
    Brain Disease Research Center, Niigata University, Japan
    Neurosci Lett 239:45-8. 1997
  9. ncbi request reprint Juvenile-onset generalized neuroaxonal dystrophy (Hallervorden-Spatz disease) with diffuse neurofibrillary and lewy body pathology
    K Wakabayashi
    Brain Disease Research Center, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951 8585, Japan
    Acta Neuropathol 99:331-6. 2000
  10. ncbi request reprint Neuropathology of autonomic nervous system in Parkinson's disease
    K Wakabayashi
    Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
    Eur Neurol 38:2-7. 1997

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Apolipoprotein E epsilon4 allele and progression of cortical Lewy body pathology in Parkinson's disease
    K Wakabayashi
    Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
    Acta Neuropathol 95:450-4. 1998
    ..It is possible that when PD occurs in individuals with APOE4, concomitantly evolving cortical LB pathology in a proportion of cases results in limbic (transitional) or neocortical-type LB disease...
  2. ncbi request reprint Accumulation of alpha-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy
    K Wakabayashi
    Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
    Acta Neuropathol 96:445-52. 1998
    ..These findings strongly suggest that the accumulation of NACP is a cytopathological feature common to LB disease and MSA...
  3. ncbi request reprint Autosomal dominant diffuse Lewy body disease
    K Wakabayashi
    Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
    Acta Neuropathol 96:207-10. 1998
    ..The apolipoprotein E genotype of the proband, her uncle and one of their sons was epsilon3/4 and that of the other son was epsilon4/4. These findings strongly suggest that this family has autosomal dominant diffuse LB disease...
  4. ncbi request reprint Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy
    K Wakabayashi
    Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
    Neurosci Lett 249:180-2. 1998
    ..These findings indicate that alpha-synuclein is also a major component of GCIs and NCIs in MSA and strongly suggest that alpha-synuclein aggregation is a common process in certain neurodegenerative diseases, including PD and MSA...
  5. ncbi request reprint NACP/alpha-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson's disease brains
    K Wakabayashi
    Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
    Acta Neuropathol 99:14-20. 2000
    ..The number of inclusions was correlated with the severity of nigral neuronal loss. These findings indicate that abnormal accumulation of NACP/alpha-synuclein in glial cells is a pathological feature of PD related to its progression...
  6. ncbi request reprint Sporadic motor neuron disease with severe sensory neuronopathy
    K Wakabayashi
    Brain Disease Research Center, Brain Research Institute, Niigata University, Asahimachi, Japan
    Acta Neuropathol 95:426-30. 1998
    ..These findings suggest that this case may be an unusual variant of sporadic MND with severe somatic sensory system involvement...
  7. ncbi request reprint Multiple system atrophy with severe involvement of the motor cortical areas and cerebral white matter
    K Wakabayashi
    Brain Disease Research Centre, Brain Research Institute, Niigata University, Japan
    J Neurol Sci 156:114-7. 1998
    ....
  8. ncbi request reprint NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease
    K Wakabayashi
    Brain Disease Research Center, Niigata University, Japan
    Neurosci Lett 239:45-8. 1997
    ..These findings suggest that alteration of NACP metabolism is involved in the pathogenesis of PD, particularly in Lewy body formation, leading to neurodegeneration...
  9. ncbi request reprint Juvenile-onset generalized neuroaxonal dystrophy (Hallervorden-Spatz disease) with diffuse neurofibrillary and lewy body pathology
    K Wakabayashi
    Brain Disease Research Center, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951 8585, Japan
    Acta Neuropathol 99:331-6. 2000
    ..The present case, together with a few similar cases reported previously, may represent a particular subset of neuroaxonal dystrophy, i.e., HSD associated with extensive accumulation of both tau and alpha-synuclein...
  10. ncbi request reprint Neuropathology of autonomic nervous system in Parkinson's disease
    K Wakabayashi
    Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
    Eur Neurol 38:2-7. 1997
    ..These findings indicate that both central and peripheral autonomic nervous systems are involved in the disease process in PD...
  11. ncbi request reprint The intermediolateral nucleus and Clarke's column in Parkinson's disease
    K Wakabayashi
    Brain Disease Research Center, Niigata University, Japan
    Acta Neuropathol 94:287-9. 1997
    ..Considering that autonomic symptoms are one of the cardinal clinical features in PD, the present finding of IML neuron loss with formation of Lewy bodies appears to be of great importance...
  12. ncbi request reprint Restricted occurrence of Lewy bodies in the dorsal vagal nucleus in a patient with late-onset parkinsonism
    K Wakabayashi
    Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
    J Neurol Sci 165:188-91. 1999
    ..Despite the use of ubiquitin and alpha-synuclein immunohistochemistry, no further LBs were identified in other brain regions. These findings suggest that this case was an unusual, anatomically restricted manifestation of LB disease...
  13. ncbi request reprint Analysis of the expression level of alpha-synuclein mRNA using postmortem brain samples from pathologically confirmed cases of multiple system atrophy
    T Ozawa
    Department of Neurology, Brain Research Institute, Niigata University, Japan
    Acta Neuropathol 102:188-90. 2001
    ..These results suggest that the transcriptional regulation of the alpha-synuclein gene is unlikely to be affected in MSA brains...
  14. ncbi request reprint Pick's disease: selective occurrence of apolipoprotein E-immunoreactive Pick bodies in the limbic system
    S Hayashi
    Department of Pathology, Niigata University, Japan
    Acta Neuropathol 95:1-4. 1998
    ....
  15. ncbi request reprint Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease
    K Okuizumi
    Department of Neurology, Niigata University, Japan
    Nat Genet 11:207-9. 1995
    ..7 (95% CI = [2.9-25.8]). Our results suggest that the VLDL-R gene is a susceptibility gene for AD...