Research Topics
| K OkuizumiSummaryAffiliation: Niigata University Country: Japan Publications
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Detail Information
Publications
Apolipoprotein E epsilon4 allele and progression of cortical Lewy body pathology in Parkinson's diseaseK Wakabayashi
Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
Acta Neuropathol 95:450-4. 1998..It is possible that when PD occurs in individuals with APOE4, concomitantly evolving cortical LB pathology in a proportion of cases results in limbic (transitional) or neocortical-type LB disease...- Accumulation of alpha-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophyK Wakabayashi
Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
Acta Neuropathol 96:445-52. 1998..These findings strongly suggest that the accumulation of NACP is a cytopathological feature common to LB disease and MSA... - Autosomal dominant diffuse Lewy body diseaseK Wakabayashi
Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
Acta Neuropathol 96:207-10. 1998..The apolipoprotein E genotype of the proband, her uncle and one of their sons was epsilon3/4 and that of the other son was epsilon4/4. These findings strongly suggest that this family has autosomal dominant diffuse LB disease... - Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophyK Wakabayashi
Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
Neurosci Lett 249:180-2. 1998..These findings indicate that alpha-synuclein is also a major component of GCIs and NCIs in MSA and strongly suggest that alpha-synuclein aggregation is a common process in certain neurodegenerative diseases, including PD and MSA... - NACP/alpha-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson's disease brainsK Wakabayashi
Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
Acta Neuropathol 99:14-20. 2000..The number of inclusions was correlated with the severity of nigral neuronal loss. These findings indicate that abnormal accumulation of NACP/alpha-synuclein in glial cells is a pathological feature of PD related to its progression... - Sporadic motor neuron disease with severe sensory neuronopathyK Wakabayashi
Brain Disease Research Center, Brain Research Institute, Niigata University, Asahimachi, Japan
Acta Neuropathol 95:426-30. 1998..These findings suggest that this case may be an unusual variant of sporadic MND with severe somatic sensory system involvement... - Multiple system atrophy with severe involvement of the motor cortical areas and cerebral white matterK Wakabayashi
Brain Disease Research Centre, Brain Research Institute, Niigata University, Japan
J Neurol Sci 156:114-7. 1998.... - NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's diseaseK Wakabayashi
Brain Disease Research Center, Niigata University, Japan
Neurosci Lett 239:45-8. 1997..These findings suggest that alteration of NACP metabolism is involved in the pathogenesis of PD, particularly in Lewy body formation, leading to neurodegeneration... - Juvenile-onset generalized neuroaxonal dystrophy (Hallervorden-Spatz disease) with diffuse neurofibrillary and lewy body pathologyK Wakabayashi
Brain Disease Research Center, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951 8585, Japan
Acta Neuropathol 99:331-6. 2000..The present case, together with a few similar cases reported previously, may represent a particular subset of neuroaxonal dystrophy, i.e., HSD associated with extensive accumulation of both tau and alpha-synuclein... - Neuropathology of autonomic nervous system in Parkinson's diseaseK Wakabayashi
Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
Eur Neurol 38:2-7. 1997..These findings indicate that both central and peripheral autonomic nervous systems are involved in the disease process in PD... - The intermediolateral nucleus and Clarke's column in Parkinson's diseaseK Wakabayashi
Brain Disease Research Center, Niigata University, Japan
Acta Neuropathol 94:287-9. 1997..Considering that autonomic symptoms are one of the cardinal clinical features in PD, the present finding of IML neuron loss with formation of Lewy bodies appears to be of great importance... - Restricted occurrence of Lewy bodies in the dorsal vagal nucleus in a patient with late-onset parkinsonismK Wakabayashi
Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
J Neurol Sci 165:188-91. 1999..Despite the use of ubiquitin and alpha-synuclein immunohistochemistry, no further LBs were identified in other brain regions. These findings suggest that this case was an unusual, anatomically restricted manifestation of LB disease... - Analysis of the expression level of alpha-synuclein mRNA using postmortem brain samples from pathologically confirmed cases of multiple system atrophyT Ozawa
Department of Neurology, Brain Research Institute, Niigata University, Japan
Acta Neuropathol 102:188-90. 2001..These results suggest that the transcriptional regulation of the alpha-synuclein gene is unlikely to be affected in MSA brains... - Pick's disease: selective occurrence of apolipoprotein E-immunoreactive Pick bodies in the limbic systemS Hayashi
Department of Pathology, Niigata University, Japan
Acta Neuropathol 95:1-4. 1998.... - Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's diseaseK Okuizumi
Department of Neurology, Niigata University, Japan
Nat Genet 11:207-9. 1995..7 (95% CI = [2.9-25.8]). Our results suggest that the VLDL-R gene is a susceptibility gene for AD...