Tsutomu Nishiyama

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. doi request reprint Serum testosterone levels after medical or surgical androgen deprivation: a comprehensive review of the literature
    Tsutomu Nishiyama
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan Electronic address
    Urol Oncol 32:38.e17-28. 2014
  2. pmc Prediction of pathological and oncological outcomes based on extended prostate biopsy results in patients with prostate cancer receiving radical prostatectomy: a single institution study
    Fumio Ishizaki
    Department of Urology, Joetsu 942 8502, Japan
    Diagn Pathol 7:68. 2012
  3. doi request reprint Androgen deprivation therapy in combination with radiotherapy for high-risk clinically localized prostate cancer
    Tsutomu Nishiyama
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1 757, Niigata 951 8510, Japan
    J Steroid Biochem Mol Biol 129:179-90. 2012
  4. ncbi request reprint Stepping-stones to the further advancement of androgen-deprivation therapy for prostate cancer
    Tsutomu Nishiyama
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1 757, Niigata 95 1 8510, Japan
    Expert Rev Anticancer Ther 6:259-68. 2006
  5. doi request reprint Intra-prostatic androgen levels during various androgen-blockade regimens
    Tsutomu Nishiyama
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Best Pract Res Clin Endocrinol Metab 22:229-41. 2008
  6. ncbi request reprint The change in the dihydrotestosterone level in the prostate before and after androgen deprivation therapy in connection with prostate cancer aggressiveness using the Gleason score
    Tsutomu Nishiyama
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Urol 178:1282-8; discussion 1288-9. 2007
  7. ncbi request reprint Influence of hot flashes on quality of life in patients with prostate cancer treated with androgen deprivation therapy
    Tsutomu Nishiyama
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1 757, Niigata 951 8510, Japan
    Int J Urol 11:735-41. 2004
  8. ncbi request reprint Association between the dihydrotestosterone level in the prostate and prostate cancer aggressiveness using the Gleason score
    Tsutomu Nishiyama
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Urol 176:1387-91. 2006
  9. ncbi request reprint The influence of androgen deprivation therapy on metabolism in patients with prostate cancer
    Tsutomu Nishiyama
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1 757, Niigata 951 8510, Japan
    J Clin Endocrinol Metab 90:657-60. 2005
  10. doi request reprint Insulin-like growth factor-1 is associated with regulation of the luteinizing hormone production in men receiving androgen deprivation therapy with gonadotropin-releasing hormone analogues for localized prostate cancer
    Noboru Hara
    Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Urol Oncol 30:596-601. 2012

Collaborators

Detail Information

Publications47

  1. doi request reprint Serum testosterone levels after medical or surgical androgen deprivation: a comprehensive review of the literature
    Tsutomu Nishiyama
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan Electronic address
    Urol Oncol 32:38.e17-28. 2014
    ..The author proposes methods to better lower serum testosterone levels during ADT...
  2. pmc Prediction of pathological and oncological outcomes based on extended prostate biopsy results in patients with prostate cancer receiving radical prostatectomy: a single institution study
    Fumio Ishizaki
    Department of Urology, Joetsu 942 8502, Japan
    Diagn Pathol 7:68. 2012
    ....
  3. doi request reprint Androgen deprivation therapy in combination with radiotherapy for high-risk clinically localized prostate cancer
    Tsutomu Nishiyama
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1 757, Niigata 951 8510, Japan
    J Steroid Biochem Mol Biol 129:179-90. 2012
    ..The use of ADT with higher doses of RT or newer RT modalities has to be properly assessed...
  4. ncbi request reprint Stepping-stones to the further advancement of androgen-deprivation therapy for prostate cancer
    Tsutomu Nishiyama
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1 757, Niigata 95 1 8510, Japan
    Expert Rev Anticancer Ther 6:259-68. 2006
    ..It is necessary to consider the androgen environment and the status of the androgen receptor in the prostate in order to improve the clinical efficacy of androgen-deprivation therapy and the quality of life of patients...
  5. doi request reprint Intra-prostatic androgen levels during various androgen-blockade regimens
    Tsutomu Nishiyama
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Best Pract Res Clin Endocrinol Metab 22:229-41. 2008
    ..This may affect the therapeutic effect of ADT. We therefore discuss the subject of prostatic androgen levels during various androgen-blockade regimens, and we describe the prospects for the future of ADT...
  6. ncbi request reprint The change in the dihydrotestosterone level in the prostate before and after androgen deprivation therapy in connection with prostate cancer aggressiveness using the Gleason score
    Tsutomu Nishiyama
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Urol 178:1282-8; discussion 1288-9. 2007
    ..We investigated the change in dihydrotestosterone in the prostate during androgen deprivation therapy in connection with prostate cancer aggressiveness using the Gleason score...
  7. ncbi request reprint Influence of hot flashes on quality of life in patients with prostate cancer treated with androgen deprivation therapy
    Tsutomu Nishiyama
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1 757, Niigata 951 8510, Japan
    Int J Urol 11:735-41. 2004
    ..We surveyed patients with prostate cancer treated with androgen deprivation therapy to examine the influence of hot flashes on quality of life (QOL)...
  8. ncbi request reprint Association between the dihydrotestosterone level in the prostate and prostate cancer aggressiveness using the Gleason score
    Tsutomu Nishiyama
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Urol 176:1387-91. 2006
    ..We analyzed dihydrotestosterone levels in the prostate and Gleason score in patients diagnosed with clinically localized prostate cancer...
  9. ncbi request reprint The influence of androgen deprivation therapy on metabolism in patients with prostate cancer
    Tsutomu Nishiyama
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1 757, Niigata 951 8510, Japan
    J Clin Endocrinol Metab 90:657-60. 2005
    ..We should be aware of the far-reaching consequences of ADT and incorporate strategies for preventing and managing adverse effects into routine practice...
  10. doi request reprint Insulin-like growth factor-1 is associated with regulation of the luteinizing hormone production in men receiving androgen deprivation therapy with gonadotropin-releasing hormone analogues for localized prostate cancer
    Noboru Hara
    Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Urol Oncol 30:596-601. 2012
    ..Despite the presence of IGF-1 receptors in the gonadotroph, associations between the GH/IGF-1 and pituitary-gonadal axes, e.g., whether IGF-1 elicits the LH secretion, remain unclear...
  11. doi request reprint Trilostane, an inhibitor of 3β-hydroxysteroid dehydrogenase, has an agonistic activity on androgen receptor in human prostate cancer cells
    Itsuhiro Takizawa
    Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1, Niigata 951 8510, Japan
    Cancer Lett 297:226-30. 2010
    ..Both cells pretreated with trilostane showed a dose-dependent decrease in PSA production with bicalutamide (P<0.001). Trilostane should be used with particular concern when treating prostate cancer...
  12. doi request reprint External validation of the UCSF-CAPRA (University of California, San Francisco, Cancer of the Prostate Risk Assessment) in Japanese patients receiving radical prostatectomy
    Fumio Ishizaki
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1, Chuo Ku, Niigata 951 8510, Japan
    Jpn J Clin Oncol 41:1259-64. 2011
    ..The aim of this study was to validate the UCSF-CAPRA score for Japanese prostate cancer patients receiving radical prostatectomy using the contemporary Gleason grading...
  13. doi request reprint Decline of the red blood cell count in patients receiving androgen deprivation therapy for localized prostate cancer: impact of ADT on insulin-like growth factor-1 and erythropoiesis
    Noboru Hara
    Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, and Department of Urology, Niigata Cancer Center Hospital, Niigata, Japan
    Urology 75:1441-5. 2010
    ....
  14. doi request reprint Deficiency in androgens and upregulation of insulin-like growth factor-1 are involved in high bone turnover in men receiving androgen deprivation therapy for prostate cancer
    Fumio Ishizaki
    Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Japan
    Growth Horm IGF Res 22:122-8. 2012
    ....
  15. doi request reprint Decrease in lean body mass in men with prostate cancer receiving androgen deprivation therapy: mechanism and biomarkers
    Noboru Hara
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Urology 81:376-80. 2013
    ..To elucidate the mechanism of the androgen deprivation therapy (ADT)-related decrease in lean body mass (LBM)...
  16. doi request reprint Adrenocorticotropic hormone is involved in regulation of androgen synthesis in men receiving androgen deprivation therapy for localized prostate cancer
    Itsuhiro Takizawa
    Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    J Urol 184:1971-6. 2010
    ..We elucidated the regulatory mechanism of adrenal androgen synthesis and examined the influence of pituitary-adrenal axis activity on prostate specific antigen during androgen deprivation therapy...
  17. doi request reprint Serum prostate-specific antigen levels reflect the androgen milieu in patients with localized prostate cancer receiving androgen deprivation therapy: Tumor malignant potential and androgen milieu
    Itsuhiro Takizawa
    Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Prostate 70:1395-401. 2010
    ....
  18. pmc Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer
    Fumio Ishizaki
    Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Sci Rep 3:1528. 2013
    ..These results suggested that 3α/β-diol also represent potential precursors of DHT, and the back conversion of DHT from androgen derivatives can be a promising target for combination hormone therapy...
  19. doi request reprint Bone metabolic disorder in patients with prostate cancer receiving androgen deprivation therapy (ADT): impact of ADT on the growth hormone/insulin-like growth factor-1/parathyroid hormone axis
    Etsuko Isahaya
    Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Prostate 70:155-61. 2010
    ..The growth hormone (GH)/insulin-like growth factor-1 (IGF-1)/parathyroid hormone (PTH) axis plays a critical role in bone synthesis, but its activity during ADT is also unknown...
  20. doi request reprint Altered association of interleukin-6 with sex steroids in lipid metabolism disorder in men with prostate cancer receiving androgen deprivation therapy
    Shuichi Komatsu
    Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Prostate 72:1207-13. 2012
    ..This study was performed to elucidate the mechanism of lipid metabolism disorder during androgen deprivation therapy (ADT) in terms of the association of interleukin-6 with sex steroids...
  21. ncbi request reprint Influence of androgen deprivation therapy on volume of anatomic zones of prostate in patients with prostate cancer using magnetic resonance imaging
    Tsutomu Nishiyama
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Urology 63:917-21. 2004
    ..To clarify the influence of androgen deprivation therapy (ADT) on the volume of the anatomic zones of the prostate and the tissue component of the transition zone...
  22. doi request reprint Kinetics of serum total and free prostate-specific antigen (PSA) after extended multisite prostate biopsy: Comparison among biopsy, transurethral resection of the prostate (TURP), and biopsy plus TURP
    Noboru Hara
    Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Urol Oncol 28:355-9. 2010
    ..The aim of this study was to examine the kinetics of hematogenous leakage of PSA molecules by comparing the postintervention PSA manner among extended biopsies, transurethral resection of the prostate (TURP) and biopsy plus TURP...
  23. pmc Retroperitoneoscopic donor nephrectomy with a gel-sealed hand-assist access device
    Kei Arai
    Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1, Niigata, 951 8510, Japan
    BMC Urol 13:7. 2013
    ....
  24. doi request reprint Successful treatment of nonocclusive mesenteric ischemia that developed during the peritransplant period following ABO-incompatible kidney transplantation
    Masayuki Tasaki
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata 951 8510, Japan
    Clin Exp Nephrol 14:199-202. 2010
    ..However, patients with end-stage renal disease are at the highest risk for this lethal condition, and physicians and urologists should correctly recognize its diagnostics and therapeutics...
  25. doi request reprint Renal cell carcinomas arising from the allograft and bilateral native kidneys
    Tomohiro Nobushita
    Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Int J Urol 15:175-7. 2008
    ..She was free of disease 18 months postoperatively. This is the first report on RCC arising both in the allograft and bilateral native kidneys...
  26. ncbi request reprint High incidence of GalNAc disialosyl lactotetraosylceramide in metastatic renal cell carcinoma
    Ryo Maruyama
    Division of Molecular Oncology, Department of Signal Transduction Research, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951 8510, Japan
    Anticancer Res 27:4345-50. 2007
    ..Here we extended the research using a larger cohort of patients with a longer follow-up period, and reevaluate their relationship to malignant potential, metastasis and prognosis in patients with RCC...
  27. ncbi request reprint The influence of androgen deprivation therapy on dihydrotestosterone levels in the prostatic tissue of patients with prostate cancer
    Tsutomu Nishiyama
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan nisiyamamed niigata u ac jp
    Clin Cancer Res 10:7121-6. 2004
    ..We analyzed dihydrotestosterone levels in prostatic tissue before and after androgen deprivation therapy...
  28. pmc Dihydrotestosterone synthesis pathways from inactive androgen 5α-androstane-3β,17β-diol in prostate cancer cells: Inhibition of intratumoural 3β-hydroxysteroid dehydrogenase activities by abiraterone
    Takashi Ando
    Niigata University Graduate School of Medical and Dental Sciences, Department of Regenerative and Transplant Medicine, Niigata, 951 8510, Japan
    Sci Rep 6:32198. 2016
    ..Additionally, the inhibition of intratumoural 3β-HSD activity could be a new approach to castration-resistant prostate cancer treatment. ..
  29. doi request reprint Kattan postoperative nomogram for renal cell carcinoma: predictive accuracy in a Japanese population
    Kazuya Suzuki
    Division of Urology, Department of Regenerative and Transplant Medicine, Course of Biological Function and Medicine Control, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan
    Int J Urol 18:194-9. 2011
    ..The aim of the current study was to establish the predictive accuracy of the Kattan postoperative nomogram for non-metastatic renal cell carcinoma (RCC) in a Japanese population...
  30. pmc Oncological results, functional outcomes and health-related quality-of-life in men who received a radical prostatectomy or external beam radiation therapy for localized prostate cancer: a study on long-term patient outcome with risk stratification
    Itsuhiro Takizawa
    Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951 8510, Japan
    Asian J Androl 11:283-90. 2009
    ..In conclusion, low- to intermediate-risk patients treated with an RP may report relatively decreased urinary function during long-term follow-up. The patient's HRQOL after treatment did not depend on biochemical recurrence...
  31. pmc Corepressive function of nuclear receptor coactivator 2 in androgen receptor of prostate cancer cells treated with antiandrogen
    Keisuke Takeda
    Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    BMC Cancer 16:332. 2016
    ....
  32. ncbi request reprint Efficacy of extracorporeal shockwave lithotripsy with patients rotated supine or rotated prone for treating ureteral stones: a case-control study
    Noboru Hara
    Department of Urology, Labor Welfare Niigata Rousai Hospital, Joetsu, and Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Japan
    J Endourol 20:170-4. 2006
    ..To improve the therapeutic efficacy of extracorporeal shockwave lithotripsy (SWL) for ureteral stones by attempting semilateral/rotated approaches. There has been no study that shows the advantage of rotated positions...
  33. doi request reprint Parathyroid hormone-related peptide-producing non-familial pheochromocytoma in a child
    Keisuke Takeda
    Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Int J Urol 17:673-6. 2010
    ..There has been no described pediatric patient with PTHrP-producing pheochromocytoma. We showed evidence that the present tumor is a complex neoplasm involving various neuroendocrine activities with the dual-lineage differentiation...
  34. ncbi request reprint Evaluation of magnetic resonance imaging-based prostate-specific antigen density of the prostate in the diagnosis of prostate cancer
    Tatsuhiko Hoshii
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Int J Urol 14:305-10. 2007
    ....
  35. pmc Management for patients with de novo or recurrent tumors in the residual kidney after surgery for nonfamilial bilateral renal cell carcinoma
    Noboru Hara
    Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951 8510, Japan
    Adv Urol . 2009
    ..Ablative techniques can potentially strike a balance between oncological and nephrological outcomes in patients with sporadic multiple RCC, successful management of which was difficult previously...
  36. doi request reprint Laparoscopic adrenalectomy for pheochromocytoma: evaluation of experience and strategy at a single institute
    Takashi Kasahara
    Niigata University Graduate School of Medical and Dental Sciences, Department of Urology, Niigata, Japan
    BJU Int 103:218-22. 2009
    ..We reviewed our experience, focusing on surgical outcomes compared with our historical open adrenalectomy (OA) and modifications in surgical procedures...
  37. ncbi request reprint Transforming growth factor-beta1 regulates cell growth and causes downregulation of SMemb/non-muscle myosin heavy chain B mRNA in human prostate stromal cells
    Kenji Obara
    Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Scand J Urol Nephrol 39:366-71. 2005
    ..The expression of the SM2 isoform of smooth muscle myosin heavy chain (SMMHC) mRNA was also examined...
  38. ncbi request reprint Pinpoint targeted immunosuppression: anti-CD20/MMF desensitization with anti-CD25 in successful ABO-incompatible kidney transplantation without splenectomy
    Kazuhide Saito
    Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Xenotransplantation 13:111-7. 2006
    ..However, we have lost some grafts due to antibody-mediated rejection (AMR) accompanying explosive elevation of anti-A/B antibody (Ab) titer even though the patients had a low pre-operative Ab titer...
  39. ncbi request reprint Primitive neuroectodermal tumor of the adrenal gland
    Shuichi Komatsu
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Int J Urol 13:606-7. 2006
    ..Although primitive neuroectodermal tumor is a highly malignant neoplasm, there is no evidence of local recurrence and distant metastasis 16 months after surgery...
  40. ncbi request reprint Influence of the great earthquake in the Chuetsu district on patients managing urination with clean intermittent self-urethral catheterization
    Tatsuhiko Hoshii
    Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Int J Urol 14:875-8. 2007
    ..During disasters, it is important that we secure CIC patients a living space, where they can perform CIC, with sufficient drinking water...
  41. doi request reprint Perioperative antibiotics in radical cystectomy with ileal conduit urinary diversion: efficacy and risk of antimicrobial prophylaxis on the operation day alone
    Noboru Hara
    Department of Urology, Niigata Cancer Center Hospital, Graduate School of Medical and Dental Science, Niigata University, Niigata, Japan
    Int J Urol 15:511-5. 2008
    ..To determine the optimum schedule for perioperative antimicrobial prophylaxis (AMP) for bladder cancer patients submitted to radical cystectomy with ileal conduit urinary diversion...
  42. pmc Testicular Seminoma With Pseudocyst and Coagulation Necrosis Like Burned-out Tumor: A Case Report
    Tatsuhiko Hoshii
    Department of Urology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Niigata, Japan
    Urol Case Rep 7:7-9. 2016
    ..We present a case of the testicular seminoma with pseudocyst and coagulation necrosis like burned-out tumor without metastasis. ..
  43. ncbi request reprint Angiomyxoid tumor with an intermediate feature between cellular angiofibroma and angiomyofibroblastoma in the male inguinal region
    Noboru Hara
    Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi, Niigata, Japan
    Int J Urol 12:768-72. 2005
    ....
  44. ncbi request reprint Androgen metabolic pathway involved in current and emerging treatment for men with castration resistant prostate cancer: intraprostatic androgens as therapeutic targets and endocrinological biomarkers
    Noboru Hara
    Asahimachi 1, Niigata 951 8510, Japan
    Curr Drug Targets 15:1215-24. 2014
    ..We critically reviewed androgen metabolism and its significance in prostate cancer biology and treatment to promote their better understanding and management of men with prostate cancer. ..
  45. ncbi request reprint Neoadjuvant chemotherapy with sequential methotrexate and 5-fluorouracil scheduling, epirubicin and cisplatin for locally advanced bladder cancer
    Tsutomu Nishiyama
    Department of Urology, Niigata University School of Medicine, Niigata, Japan
    Oncology 63:1-5. 2002
    ..In several clinical series, sequentially delivered methotrexate and 5-fluorouracil followed by leucovorin rescue in expectation of a biochemical modulation has a higher response rate...
  46. ncbi request reprint Renography as a measure of renal and neobladder function in patients with ileal bladder substitution
    Tsutomu Nishiyama
    Department of Urology, Koseiren Nagaoka Chuo General Hospital, Niigata, Japan
    Urol Int 68:168-71. 2002
    ..Using renography, we evaluated the function of both the kidneys and neobladder of 20 patients who underwent ileal bladder substitution...
  47. ncbi request reprint [Intermittent oral hormonal chemotherapy using estramustine phosphate and etoposide for the treatment of hormone-refractory prostate cancer]
    Motohiko Kimura
    Department of Urology, Niigata Kobari Hospital
    Hinyokika Kiyo 49:709-14. 2003
    ..Because of its rare and mild adverse effects, this intermittent administration of oral estramustine and oral etoposide may be a useful and secure regimen for hormone refractory prostate cancer...