Affiliation: Niigata University
Yukawa T, Iwakura Y, Takei N, Saito M, Watanabe Y, Toyooka K, et al
. Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia. Psychiatry Res. 2018;270:940-946 pubmed publisher
..These results suggest that the level alteration of the chondroitin 4-sulfate moiety might contribute to the perineuronal net abnormality found in patients with schizophrenia. ..
Nawa H, Yamada K. Experimental schizophrenia models in rodents established with inflammatory agents and cytokines. Methods Mol Biol. 2012;829:445-51 pubmed publisher
..In this chapter, we introduce the details of the procedure and discuss the potential application of these animal models to drug development for schizophrenia. ..
Kato T, Abe Y, Hirokawa S, Iwakura Y, Mizuno M, Namba H, et al
. Neurobehavioral Differences Between Mice Receiving Distinct Neuregulin Variants as Neonates; Impact on Sensitivity to MK-801. Curr Mol Med. 2015;15:222-36 pubmed
..Collectively, our findings suggest that aberrant peripheral NRG1 signals during neurodevelopment alter later behavioral traits and auditory functions in the NRG1 subtype-dependent manner. ..
Nagano T, Mizuno M, Morita K, Nawa H. Pathological Implications of Oxidative Stress in Patients and Animal Models with Schizophrenia: The Role of Epidermal Growth Factor Receptor Signaling. Curr Top Behav Neurosci. 2016;29:429-446 pubmed publisher
Sotoyama H, Iwakura Y, Oda K, Sasaoka T, Takei N, Kakita A, et al
. Striatal hypodopamine phenotypes found in transgenic mice that overexpress glial cell line-derived neurotrophic factor. Neurosci Lett. 2017;654:99-106 pubmed publisher
..These results suggest that chronic overexpression of GDNF in brain astrocytes exerts an opposing influence on nigrostriatal dopamine metabolism and neurotransmission. ..