H Nawa

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. pmc ErbB inhibitors ameliorate behavioral impairments of an animal model for schizophrenia: implication of their dopamine-modulatory actions
    M Mizuno
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    Transl Psychiatry 3:e252. 2013
  2. pmc ErbB2 dephosphorylation and anti-proliferative effects of neuregulin-1 in ErbB2-overexpressing cells; re-evaluation of their low-affinity interaction
    Ran Wang
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, 951 8585, Japan
    Sci Rep 3:1402. 2013
  3. pmc Phenotypic characterization of transgenic mice overexpressing neuregulin-1
    Taisuke Kato
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    PLoS ONE 5:e14185. 2010
  4. pmc Pallidal hyperdopaminergic innervation underlying D2 receptor-dependent behavioral deficits in the schizophrenia animal model established by EGF
    Hidekazu Sotoyama
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    PLoS ONE 6:e25831. 2011
  5. ncbi request reprint BDNF as an anterophin; a novel neurotrophic relationship between brain neurons
    H Nawa
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, 951 8585 Japan
    Trends Neurosci 24:683-4; discussion 684-5. 2001
  6. doi request reprint Experimental schizophrenia models in rodents established with inflammatory agents and cytokines
    Hiroyuki Nawa
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    Methods Mol Biol 829:445-51. 2012
  7. ncbi request reprint Recent progress in animal modeling of immune inflammatory processes in schizophrenia: implication of specific cytokines
    Hiroyuki Nawa
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata, Japan
    Neurosci Res 56:2-13. 2006
  8. ncbi request reprint Epidermal growth factor administered in the periphery influences excitatory synaptic inputs onto midbrain dopaminergic neurons in postnatal mice
    H Namba
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Chuo Ku, Niigata 951 8585, Japan
    Neuroscience 158:1731-41. 2009
  9. ncbi request reprint The cellular and behavioral consequences of interleukin-1 alpha penetration through the blood-brain barrier of neonatal rats: a critical period for efficacy
    M Tohmi
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    Neuroscience 150:234-50. 2007
  10. doi request reprint Transient exposure of neonatal mice to neuregulin-1 results in hyperdopaminergic states in adulthood: implication in neurodevelopmental hypothesis for schizophrenia
    T Kato
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    Mol Psychiatry 16:307-20. 2011

Collaborators

Detail Information

Publications76

  1. pmc ErbB inhibitors ameliorate behavioral impairments of an animal model for schizophrenia: implication of their dopamine-modulatory actions
    M Mizuno
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    Transl Psychiatry 3:e252. 2013
    ..ErbB inhibitors appear to have anti-dopaminergic actions to alleviate some of the behavioral deficits common to animal models for schizophrenia...
  2. pmc ErbB2 dephosphorylation and anti-proliferative effects of neuregulin-1 in ErbB2-overexpressing cells; re-evaluation of their low-affinity interaction
    Ran Wang
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, 951 8585, Japan
    Sci Rep 3:1402. 2013
    ..These results suggest that the higher concentrations of neuregulin-1 exert an anti-oncogenic activity to attenuate ErbB2 auto-phosphorylation potentially through its low-affinity interaction with ErbB2...
  3. pmc Phenotypic characterization of transgenic mice overexpressing neuregulin-1
    Taisuke Kato
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    PLoS ONE 5:e14185. 2010
    ..However, the psychobehavioral implication of NRG1 signaling has mainly been investigated using hypomorphic mutant mice for individual NRG1 splice variants...
  4. pmc Pallidal hyperdopaminergic innervation underlying D2 receptor-dependent behavioral deficits in the schizophrenia animal model established by EGF
    Hidekazu Sotoyama
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    PLoS ONE 6:e25831. 2011
    ..These findings suggest that the pallidal dopaminergic innervation is vulnerable to circulating EGF at perinatal and/or neonatal stages and has strong impact on the D2-like receptor-dependent behavioral deficits relevant to schizophrenia...
  5. ncbi request reprint BDNF as an anterophin; a novel neurotrophic relationship between brain neurons
    H Nawa
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, 951 8585 Japan
    Trends Neurosci 24:683-4; discussion 684-5. 2001
    ..Accordingly, BDNF serves as an anterophin to regulate postsynaptic development and plasticity in the central nervous system...
  6. doi request reprint Experimental schizophrenia models in rodents established with inflammatory agents and cytokines
    Hiroyuki Nawa
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    Methods Mol Biol 829:445-51. 2012
    ..In this chapter, we introduce the details of the procedure and discuss the potential application of these animal models to drug development for schizophrenia...
  7. ncbi request reprint Recent progress in animal modeling of immune inflammatory processes in schizophrenia: implication of specific cytokines
    Hiroyuki Nawa
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata, Japan
    Neurosci Res 56:2-13. 2006
    ..The neurodevelopmental and behavioral consequences of prenatal/perinatal cytokine activity are compared with those of other schizophrenia models and cytokine interactions with genes are also discussed in this review...
  8. ncbi request reprint Epidermal growth factor administered in the periphery influences excitatory synaptic inputs onto midbrain dopaminergic neurons in postnatal mice
    H Namba
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Chuo Ku, Niigata 951 8585, Japan
    Neuroscience 158:1731-41. 2009
    ..Thus, these results suggest that circulating EGF substantially influences the physiological properties of developing midbrain dopaminergic neurons in perinatal and postnatal mice...
  9. ncbi request reprint The cellular and behavioral consequences of interleukin-1 alpha penetration through the blood-brain barrier of neonatal rats: a critical period for efficacy
    M Tohmi
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    Neuroscience 150:234-50. 2007
    ..During early development, therefore, circulating IL-1 alpha efficiently crosses the blood-brain barrier to induce inflammatory reactions in the brain and influences later behavioral traits...
  10. doi request reprint Transient exposure of neonatal mice to neuregulin-1 results in hyperdopaminergic states in adulthood: implication in neurodevelopmental hypothesis for schizophrenia
    T Kato
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    Mol Psychiatry 16:307-20. 2011
    ..Collectively, our findings provide novel insights into neurotrophic contribution of NRG1 to dopaminergic maldevelopment and schizophrenia pathogenesis...
  11. ncbi request reprint Neonatal perturbation of neurotrophic signaling results in abnormal sensorimotor gating and social interaction in adults: implication for epidermal growth factor in cognitive development
    T Futamura
    Molecular Neurobiology, Brain Research Institute, Niigata University, Japan
    Mol Psychiatry 8:19-29. 2003
    ....
  12. pmc ErbB1 receptor ligands attenuate the expression of synaptic scaffolding proteins, GRIP1 and SAP97, in developing neocortex
    D Yokomaku
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi dori 1 757, Niigata 951 8585, Japan
    Neuroscience 136:1037-47. 2005
    ..These findings revealed a novel negative activity of ErbB1 receptor ligands that attenuates the expression of the PDZ proteins and inhibits postsynaptic maturation in developing neocortex...
  13. doi request reprint The anthraquinone derivative Emodin ameliorates neurobehavioral deficits of a rodent model for schizophrenia
    M Mizuno
    Center for Transdisciplinary Research, Niigata University, Niigata, Japan
    J Neural Transm 115:521-30. 2008
    ..We conclude that emodin can both attenuate EGF receptor signaling and ameliorate behavioral deficits. Therefore, emodin might be a novel class of a pro-drug for anti-psychotic medication...
  14. doi request reprint In situ hybridization reveals developmental regulation of ErbB1-4 mRNA expression in mouse midbrain: implication of ErbB receptors for dopaminergic neurons
    Y Abe
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Chuo Ku, Niigata 951 8585, Japan
    Neuroscience 161:95-110. 2009
    ..The robust and restricted expression of ErbB4 mRNA in the midbrain dopaminergic neurons suggests that ErbB4 ligands, neuregulin-1 and other EGF-related molecules, contribute to development or maintenance of this neuronal population...
  15. ncbi request reprint Enhancement of translation elongation in neurons by brain-derived neurotrophic factor: implications for mammalian target of rapamycin signaling
    Naoko Inamura
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    J Neurochem 95:1438-45. 2005
    ..These results strongly suggest that BDNF enhances translation elongation through the activation of the mTOR-eEF2 pathway...
  16. ncbi request reprint Brain-derived neurotrophic factor enhances neuronal translation by activating multiple initiation processes: comparison with the effects of insulin
    N Takei
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi 1, Niigata 951 8585, Japan
    J Biol Chem 276:42818-25. 2001
    ..These results suggest strongly that BDNF simultaneously activates multiple signaling cascades consisting of phosphatidylinositol 3-kinase, mammalian TOR, and MAPK to enhance translation initiation in neurons...
  17. ncbi request reprint N-methyl-D-aspartate-induced alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptor down-regulation involves interaction of the carboxyl terminus of GluR2/3 with Pick1. Ligand-binding studies using Sindbis vectors carrying AMPA receptor
    Y Iwakura
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi-dori 1-757, Niigata 951-8585, Japan
    J Biol Chem 276:40025-32. 2001
    ..Therefore, these observations suggest that the NMDA-induced down-regulation of the functional AMPA receptors involves the interaction between GluR2/3 subunits and Pick1...
  18. ncbi request reprint Transforming growth factor-alpha changes firing properties of developing neocortical GABAergic neurons by down-regulation of voltage-gated potassium currents
    H Namba
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata 951 8585, Japan
    Neuroscience 122:637-46. 2003
    ..Thus, chronic treatment with TGFalpha down-regulated slow delayed rectifier and transient voltage-gated potassium currents, and in parallel, suppressed repetitive generation of action potentials in the cortical GABAergic neurons...
  19. ncbi request reprint [Contribution of neurotrophic factors and cytokines to schizophrenia]
    Hiroyuki Nawa
    Brain Research Institute, Niigata University
    Nihon Rinsho 61:521-8. 2003
    ..Based on this result, a novel animal model for schizophrenia has been established by perturbing the neurotrophic signaling during development. This review summarizes the latest progress of these studies...
  20. pmc Regulation of nerve growth factor release by nitric oxide through cyclic GMP pathway in cortical glial cells
    H Xiong
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    Mol Pharmacol 56:339-47. 1999
    ..Taken together, we conclude NO derived mainly from microglia down-regulates NGF release from astroglia at the transcriptional level by stimulating cyclic GMP pathway...
  21. ncbi request reprint In vivo administration of epidermal growth factor and its homologue attenuates developmental maturation of functional excitatory synapses in cortical GABAergic neurons
    Tadasato Nagano
    Molecular Neurobiology, Brain Research Institute, Niigata University, 951 8585 Japan
    Eur J Neurosci 25:380-90. 2007
    ..We conclude that EGF or other ErbB1 ligand(s) attenuates a developmental increase in AMPA receptor expression and function in cortical GABAergic neurons...
  22. ncbi request reprint Sustained brain-derived neurotrophic factor up-regulation and sensorimotor gating abnormality induced by postnatal exposure to phencyclidine: comparison with adult treatment
    Makoto Takahashi
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Neurochem 99:770-80. 2006
    ..This study suggests that phencyclidine exposure during brain development induces sustained BDNF up-regulation in the limbic system with a biological link to sensorimotor gating deficits...
  23. ncbi request reprint Strain-dependent behavioral alterations induced by peripheral interleukin-1 challenge in neonatal mice
    Noriko Tsuda
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    Behav Brain Res 166:19-31. 2006
    ..The present animal study suggests that, in early postnatal development, circulating IL-1alpha trigger brain cytokine signaling and produce distinct influences on later neurobehavioral traits, both depending on genetic background...
  24. ncbi request reprint Influences of dopaminergic lesion on epidermal growth factor-ErbB signals in Parkinson's disease and its model: neurotrophic implication in nigrostriatal neurons
    Yuriko Iwakura
    Molecular Neurobiology, Brain Research Institute, Niigata University, Japan
    J Neurochem 93:974-83. 2005
    ..These findings suggest that the neurotrophic activity of EGF is maintained by afferent signals of midbrain dopaminergic neurons and is impaired in patients with Parkinson's disease...
  25. doi request reprint Activation of epidermal growth factor receptor ErbB1 attenuates inhibitory synaptic development in mouse dentate gyrus
    Yuichi Abe
    Department of Mol Neurobiol, Brain Res Inst, Niigata Univ, Niigata, Japan
    Neurosci Res 63:138-48. 2009
    ..In parallel, EGF down-regulated the protein level of vesicular GABA transporter. Thus, ErbB1 ligands influence GABAergic inhibitory synaptic transmission in the developing dentate gyrus...
  26. ncbi request reprint BDNF is upregulated by postnatal development and visual experience: quantitative and immunohistochemical analyses of BDNF in the rat retina
    Masaaki Seki
    Department of Molecular Neurobiology, Brain Research Institute, and Division of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Invest Ophthalmol Vis Sci 44:3211-8. 2003
    ..This study sought to elucidate changes in the levels and distribution of brain-derived neurotrophic factor (BDNF) in the retina throughout aging and depending on visual experience...
  27. ncbi request reprint Cellular and subcellular distributions of translation initiation, elongation and release factors in rat hippocampus
    Naoko Inamura
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi 1, Niigata 951 8585, Japan
    Brain Res Mol Brain Res 111:165-74. 2003
    ..These results suggest that regulated protein synthesis occurs in the hippocampus, with differences existing between different subregions such as CA1, CA3 and dentate gyrus...
  28. doi request reprint Measurement and comparison of serum neuregulin 1 immunoreactivity in control subjects and patients with schizophrenia: an influence of its genetic polymorphism
    M Shibuya
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757, Asahimachi Dori, Niigata, 951 8585, Japan
    J Neural Transm 117:887-95. 2010
    ..These findings suggest that serum NRG1 levels are decreased in patients with chronic schizophrenia and influenced by their SNP8NRG243177 alleles...
  29. ncbi request reprint Perinatal inflammatory cytokine challenge results in distinct neurobehavioral alterations in rats: implication in psychiatric disorders of developmental origin
    Manavu Tohmi
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi dori 1 757, Niigata 951 8585, Japan
    Neurosci Res 50:67-75. 2004
    ....
  30. pmc Brain-derived neurotrophic factor signal enhances and maintains the expression of AMPA receptor-associated PDZ proteins in developing cortical neurons
    Hussam Jourdi
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, 951 8585, Japan
    Dev Biol 263:216-30. 2003
    ..This work reveals a novel function of BDNF in postsynaptic development by regulating the PDZ protein expression...
  31. ncbi request reprint Brain-derived neurotrophic factor upregulates and maintains AMPA receptor currents in neocortical GABAergic neurons
    T Nagano
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 951 8585 Nigata, Japan
    Mol Cell Neurosci 24:340-56. 2003
    ..These findings indicate that the neurotrophin enhances the input sensitivity of GABAergic neurons to facilitate their inhibitory function in the neocortex...
  32. ncbi request reprint Patients with temporal lobe epilepsy show an increase in brain-derived neurotrophic factor protein and its correlation with neuropeptide Y
    M Takahashi
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    Brain Res 818:579-82. 1999
    ..Thus, these results indicate the activity-dependent expression of BDNF in human subjects and its potential contribution to the pathophysiology of human epilepsy via neuropeptide Y...
  33. ncbi request reprint Brain-derived neurotrophic factor modulates glucagon secretion from pancreatic alpha cells: its contribution to glucose metabolism
    O Hanyu
    Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Diabetes Obes Metab 5:27-37. 2003
    ..The potential effect of BDNF directly on peripheral endocrine organs, however, remains to be clarified. Here we report the effects of BDNF on hormonal secretion from pancreatic islets of Langerhans using their isolated culture...
  34. doi request reprint The anthraquinone derivative emodin attenuates methamphetamine-induced hyperlocomotion and startle response in rats
    Makoto Mizuno
    Center for Transdisciplinary Research, Niigata University, Niigata, Japan
    Pharmacol Biochem Behav 97:392-8. 2010
    ..These findings suggest that emodin has unique pharmacological activity, which interferes with acute methamphetamine signaling and behavior...
  35. pmc Transforming growth factor alpha attenuates the functional expression of AMPA receptors in cortical GABAergic neurons
    Hisaaki Namba
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata 951 8585, Japan
    Mol Cell Neurosci 31:628-41. 2006
    ..These observations reveal a negative regulatory activity of the ErbB1 ligand, TGFalpha, which reduces the input sensitivity of cortical GABAergic neurons to attenuate their inhibitory function...
  36. doi request reprint Cytokine hypothesis of schizophrenia pathogenesis: evidence from human studies and animal models
    Yuichiro Watanabe
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Psychiatry Clin Neurosci 64:217-30. 2010
    ..In this review, we discuss the neurobiological mechanisms underlying schizophrenia and novel antipsychotic candidates based on the cytokine hypothesis...
  37. doi request reprint Leucine induces phosphorylation and activation of p70S6K in cortical neurons via the system L amino acid transporter
    Yuta Ishizuka
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    J Neurochem 106:934-42. 2008
    ..We propose that leucine plays important roles in regulating signaling by p70S6 kinase by acting as an intercellular communicator in the CNS...
  38. doi request reprint Common behavioral influences of the ErbB1 ligands transforming growth factor alpha and epiregulin administered to mouse neonates
    Noriko Tsuda
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    Brain Dev 30:533-43. 2008
    ..Abnormal ErbB1 ligand production at neonatal and potentially prenatal stages might therefore associate with neurodevelopmental disorders such as schizophrenia...
  39. ncbi request reprint Selective reduction of a PDZ protein, SAP-97, in the prefrontal cortex of patients with chronic schizophrenia
    Kazuhiko Toyooka
    Molecular Neurobiology, Brain Research Institute, Niigata University, Japan
    J Neurochem 83:797-806. 2002
    ..In addition, neuroleptic treatment failed to mimic the SAP97 change. These findings suggest that a phenotypic loss of SAP97 is associated with the postsynaptic impairment in prefrontal excitatory circuits of schizophrenic patients...
  40. pmc Brain-derived neurotrophic factor enhances the basal rate of protein synthesis by increasing active eukaryotic elongation factor 2 levels and promoting translation elongation in cortical neurons
    Nobuyuki Takei
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    J Biol Chem 284:26340-8. 2009
    ..Taken together, our results demonstrate that the increased level of active eEF2 induced by chronic BDNF stimulation enhances translational elongation processes and increases the total rate of protein synthesis in neurons...
  41. doi request reprint Association study of interleukin 2 (IL2) and IL4 with schizophrenia in a Japanese population
    Yuichiro Watanabe
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachidori ichibancho, Chuo Ku, Niigata 951 8510, Japan
    Eur Arch Psychiatry Clin Neurosci 258:422-7. 2008
    ..The present study suggests that IL2 and IL4 do not contribute to vulnerability to schizophrenia in the Japanese population...
  42. ncbi request reprint Conditioned place preference and locomotor sensitization after repeated administration of cocaine or methamphetamine in rats treated with epidermal growth factor during the neonatal period
    Makoto Mizuno
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    Ann N Y Acad Sci 1025:612-8. 2004
    ..Our findings indicate a potential link between EGF-receptor activation and drug addiction...
  43. ncbi request reprint Distinct influences of neonatal epidermal growth factor challenge on adult neurobehavioral traits in four mouse strains
    Manavu Tohmi
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi dori 1 757, Niigata, 951 8585, Japan
    Behav Genet 35:615-29. 2005
    ..Genetic components regulating brain ErbB1 signaling strongly influence the direction and strength of behavioral responses stemming from the neonatal neurotrophic perturbation...
  44. ncbi request reprint Neonatal impact of leukemia inhibitory factor on neurobehavioral development in rats
    Yuichiro Watanabe
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi dori 1 757, Niigata 951 8585, Japan
    Neurosci Res 48:345-53. 2004
    ..These results indicate that LIF induction in the periphery of the infant has a significant, but discrete impact on neurobehavioral development...
  45. ncbi request reprint Differential distributions of peptides in the epidermal growth factor family and phosphorylation of ErbB 1 receptor in adult rat brain
    Ying shan Piao
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi dori 1 757, Niigata 951 8585, Japan
    Neurosci Lett 390:21-4. 2005
    ..These observations suggest that the activation of brain ErbB 1 involves post-translational regulation of multiple EGF family members in a region-specific manner...
  46. ncbi request reprint Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites
    Nobuyuki Takei
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    J Neurosci 24:9760-9. 2004
    ..Taken together, these data indicate that mTOR-dependent translation activation is essential for the upregulation of local protein synthesis in neuronal dendrites...
  47. ncbi request reprint Quantitative analyses of mRNA and protein levels of neurotrophin-3 in the rat retina during postnatal development and aging
    Masaaki Seki
    Division of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951 8585, Japan
    Jpn J Ophthalmol 48:460-4. 2004
    ..In this study, we sought to elucidate changes in the levels of neurotrophin-3 (NT-3) in the rat retina throughout postnatal development and aging...
  48. ncbi request reprint Involvement of brain-derived neurotrophic factor in early retinal neuropathy of streptozotocin-induced diabetes in rats: therapeutic potential of brain-derived neurotrophic factor for dopaminergic amacrine cells
    Masaaki Seki
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata, Niigata 951 8585, Japan
    Diabetes 53:2412-9. 2004
    ..These findings suggest that the early retinal neuropathy of diabetes involves the reduced expression of BDNF and can be ameliorated by an exogenous supply of this neurotrophin...
  49. ncbi request reprint Neonatal exposure to epidermal growth factor induces dopamine D2-like receptor supersensitivity in adult sensorimotor gating
    Hidekazu Sotoyama
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi dori 1 757, Niigata, 951 8585, Japan
    Psychopharmacology (Berl) 191:783-92. 2007
    ..Thus, rats treated with EGF as neonates are used as a putative animal model for schizophrenia showing impaired prepulse inhibition (PPI) and other cognitive deficits in the adult stage...
  50. ncbi request reprint Müller Cells as a source of brain-derived neurotrophic factor in the retina: noradrenaline upregulates brain-derived neurotrophic factor levels in cultured rat Müller cells
    Masaaki Seki
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi, 951 8585, Nigata, Nigata, Japan
    Neurochem Res 30:1163-70. 2005
    ..These results suggest that Müller cells may act as an endogenous source of BDNF in the retina. Furthermore, induction of BDNF expression by adrenergic agonists may provide a therapeutic approach to retinal neurodegenerative disorders...
  51. ncbi request reprint Activity-dependent shedding of heparin-binding EGF-like growth factor in brain neurons
    Yuji Shishido
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    Biochem Biophys Res Commun 348:963-70. 2006
    ..Therefore, we propose that glutamatergic neurotransmission in the central nervous system plays a crucial role in regulating ectodomain shedding of pro-HB-EGF...
  52. ncbi request reprint Abnormal expression of epidermal growth factor and its receptor in the forebrain and serum of schizophrenic patients
    T Futamura
    Molecular Neurobiology, Brain Research Institute, Niigata University, Japan
    Mol Psychiatry 7:673-82. 2002
    ....
  53. doi request reprint Molecular characterization and gene disruption of a novel zinc-finger protein, HIT-4, expressed in rodent brain
    Yasutaka Tanabe
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    J Neurochem 112:1035-44. 2010
    ..These results reveal novel biological and pathological roles of HIT-4 in brain development and/or maintenance...
  54. doi request reprint Activation of mammalian target of rapamycin signaling in spatial learning
    Sihua Qi
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1, Asahimachi, Niigata 951 8585, Japan
    Neurosci Res 68:88-93. 2010
    ..Thus, mTOR signaling is activated during learning, enhances translation, and plays a crucial role in the spatial learning...
  55. ncbi request reprint Decreased levels of brain-derived neurotrophic factor in serum of chronic schizophrenic patients
    Kazuhiko Toyooka
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University Asahimachi dori 1 757, Niigata 951 8585, Japan
    Psychiatry Res 110:249-57. 2002
    ..The BDNF reduction in serum but not in whole blood suggests a potential deficit in neurotrophic factor release in patients with schizophrenia...
  56. ncbi request reprint [Modulation of brain function by neurotrophins]
    Nobuyuki Takei
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951 8585, Japan
    Seikagaku 76:111-23. 2004
  57. ncbi request reprint Developmental changes of eukaryotic initiation factor 2B subunits in rat hippocampus
    Naoko Inamura
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi 1, Niigata Niigata 951 8585, Japan
    Neurosci Lett 346:117-9. 2003
    ..Aged hippocampus contained only trace amounts of these subunits. The finding that eIF2B subunit levels are high in developing hippocampus suggests that regulated protein synthesis is active in young, highly plastic brain...
  58. ncbi request reprint Field potential recording in the ventral tegmental area: pharmacological and toxicological evaluations of postsynaptic dopaminergic neuron activity
    Yingjun Zheng
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata 951 8585, Japan
    Neurosci Res 55:426-33. 2006
    ..This result suggests that at least 50% of the observed transsynaptic component reflected the postsynaptic responses of the dopaminergic neurons...
  59. ncbi request reprint A decrease in interleukin-1 receptor antagonist expression in the prefrontal cortex of schizophrenic patients
    Kazuhiko Toyooka
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi dori 1 757, 951 8585, Niigata, Japan
    Neurosci Res 46:299-307. 2003
    ..IL-1RA reduction might reflect an immunopathologic trait of the prefrontal region in schizophrenic patients...
  60. doi request reprint Cyclooxygenase-2 plays a critical role in retinal ganglion cell death after transient ischemia: real-time monitoring of RGC survival using Thy-1-EGFP transgenic mice
    Yasuhiro Sakai
    Division of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, 1, Asahimachi, Niigata 951 8585, Japan
    Neurosci Res 65:319-25. 2009
    ..Our data show that COX-2 plays a crucial role in ischemia-reperfusion injury-induced RGC death. Inhibition of COX-2 activity may therefore be an effective therapy for neurodegenerative diseases of the retina and optic nerve...
  61. ncbi request reprint A novel rat orthologue and homologue for the Drosophila crooked neck gene in neural stem cells and their immediate descendants
    Naoki Amada
    Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi dori 1 757, Niigata 951 8585, Japan
    J Biochem 133:615-23. 2003
    ..These findings suggest that both TPR-motif-containing proteins are involved in RNA processing of mammalian neural stem cells and their immediate descendants...
  62. doi request reprint Expression of ErbB4 in substantia nigra dopamine neurons of monkeys and humans
    Yingjun Zheng
    Department of Molecular Neurobiology, Brain Research Institute, University of Niigata, Niigata 951 8585, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:701-6. 2009
    ..These observations suggest that ErbB4 is expressed in the dopaminergic neurons of primate substantia nigra and ErbB4 abnormality might contribute to the dopaminergic pathology associated with schizophrenia or other brain diseases...
  63. ncbi request reprint Establishment of a novel enzyme-linked immunosorbent assay for Thy-1; quantitative assessment of neuronal degeneration
    Masaaki Seki
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi 1, 951 8585 Niigata, Japan
    Neurosci Lett 329:185-8. 2002
    ..We found that injection of a neurotoxin, N-methyl-D-aspartate, into the vitreous cavity reduced the Thy-1 level in the retina. Thy-1 ELISA will be useful for quantitative assessment of neurodegeneration in the CNS...
  64. ncbi request reprint A cyclooxygenase-2 inhibitor ameliorates behavioral impairments induced by striatal administration of epidermal growth factor
    Makoto Mizuno
    Center for Transdisciplinary Research, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    J Neurosci 27:10116-27. 2007
    ..We conclude that this EGF-triggered neuroinflammatory process is mediated in part by Cox-2 activity and perturbs dopamine metabolism to generate neurobehavioral abnormalities...
  65. ncbi request reprint Brain-derived neurotrophic factor regulates surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptors by enhancing the N-ethylmaleimide-sensitive factor/GluR2 interaction in developing neocortical neurons
    Mako Narisawa-Saito
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    J Biol Chem 277:40901-10. 2002
    ..These results reveal a novel role of BDNF in regulating the surface expression of AMPA receptors through a GluR2-NSF interaction...
  66. ncbi request reprint Prefrontal abnormality of schizophrenia revealed by DNA microarray: impact on glial and neurotrophic gene expression
    Tetsuji Sugai
    Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    Ann N Y Acad Sci 1025:84-91. 2004
    ..The present profiling study suggests a potential biological link between abnormal neurotrophic signals and impaired glial functions in schizophrenic pathology...
  67. ncbi request reprint A palmitoylated RING finger ubiquitin ligase and its homologue in the brain membranes
    Kazuaki Araki
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    J Neurochem 86:749-62. 2003
    ..In agreement, Sakura associating with the membrane was specifically palmitoylated. Although the molecular targets of their Ub ligation remain to be identified, these findings imply a novel function of the palmitoylated E3 Ub ligase(s)...
  68. ncbi request reprint Over-expression of Kv1.5 in rat cardiomyocytes extremely shortens the duration of the action potential and causes rapid excitation
    Yasutaka Tanabe
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan
    Biochem Biophys Res Commun 345:1116-21. 2006
    ..Genetically abnormal action potential duration (APD) can be a cause of arrhythmias that include long and short QT interval syndrome...
  69. ncbi request reprint Possible involvement of BDNF release in long-lasting synapse formation induced by repetitive PKA activation
    Naoko Taniguchi
    Department of Neuroscience, Osaka University Graduate School of Frontier Biosciences, Machikaneyama cho 1 1, Toyonaka, Osaka 560 0043, Japan
    Neurosci Lett 406:38-42. 2006
    ..The release of BDNF upon PKA activation was confirmed by phosphorylation of TrkB. These results indicate that the release of BDNF is involved in the putative signaling cascade connecting PKA activation and synapse formation...
  70. ncbi request reprint Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects
    Tommi Saarelainen
    Department of Neurobiology, A I Virtanen Institute, University of Kuopio, 70211 Kuopio, Finland
    J Neurosci 23:349-57. 2003
    ..Neurotrophin signaling increased by antidepressants may induce formation and stabilization of synaptic connectivity, which gradually leads to the clinical antidepressive effects and mood recovery...
  71. ncbi request reprint PACAP and NGF cooperatively enhance choline acetyltransferase activity in postnatal basal forebrain neurons by complementary induction of its different mRNA species
    Aki Yuhara
    Institute for Protein Research, Osaka University, 3 2 Yamadaoka, Suita, 565 0871, Osaka, Japan
    Biochem Biophys Res Commun 301:344-9. 2003
    ..These results explain the cooperative neurotrophic action of NGF and PACAP on postnatal cholinergic neurons...
  72. ncbi request reprint Action-potential-independent GABAergic tone mediated by nicotinic stimulation of immature striatal miniature synaptic transmission
    Zhi Liu
    Kinsmen Laboratory and Brain Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurophysiol 98:581-93. 2007
    ..Current-clamp recordings confirmed a direct depolarizing action of nicotine that could dampen eIPSC activity leading to a switch to striatal inhibitory synaptic transmission mediated by tonic mIPSCs...
  73. ncbi request reprint Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors
    Toshiyuki Araki
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Biol Chem 278:41677-84. 2003
    ....
  74. ncbi request reprint Shp-2 positively regulates brain-derived neurotrophic factor-promoted survival of cultured ventral mesencephalic dopaminergic neurons through a brain immunoglobulin-like molecule with tyrosine-based activation motifs/Shp substrate-1
    Satomi Takai
    Division of Protein Biosynthesis, Institute for Protein Research, Osaka University, Suita, Japan
    J Neurochem 82:353-64. 2002
    ..Dephosphorylation of BIT/SHPS-1 by Shp-2 may participate in BDNF-stimulated survival signaling...
  75. ncbi request reprint Immunohistochemical study of brain-derived neurotrophic factor and its receptor, TrkB, in the hippocampal formation of schizophrenic brains
    Shuji Iritani
    Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, 2 1 1 Kamikitazawa, Setagaya, Tokyo 156 0057, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 27:801-7. 2003
    ....
  76. pmc Dopamine D1 receptor-induced signaling through TrkB receptors in striatal neurons
    Yuriko Iwakura
    Molecular Neurobiology Program, Kimmel Center at Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 283:15799-806. 2008
    ..These results indicate that stimulation of dopamine D1 receptors can be coupled to the neurotrophin receptor signaling to mediate the effects of dopamine upon striatal neurons...