I Narita

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. ncbi request reprint Uremic pruritus in chronic hemodialysis patients
    Ichiei Narita
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Nephrol 21:161-5. 2008
  2. pmc Distribution of amyloid deposits in the kidneys of a patient with reactive amyloidosis associated with rheumatoid arthritis
    Takeshi Kuroda
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City 951 8510, Japan
    BMC Res Notes 6:231. 2013
  3. pmc Significant association between renal function and amyloid-positive area in renal biopsy specimens in AL amyloidosis
    Takeshi Kuroda
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata City, 951 8510, Japan
    BMC Nephrol 13:118. 2012
  4. pmc Henoch Schönlein purpura associated with pulmonary adenocarcinoma
    Daiki Mifune
    Department of Medicine II, Niigata University Medical and Dental Hospital, 951 8520 Niigata, Japan
    J Med Case Reports 5:226. 2011
  5. pmc Clinical responses to EGFR-tyrosine kinase inhibitor retreatment in non-small cell lung cancer patients who benefited from prior effective gefitinib therapy: a retrospective analysis
    Satoshi Watanabe
    Department of Medicine, Niigata University Medical and Dental Hospital, Niigata City, Japan
    BMC Cancer 11:1. 2011
  6. ncbi request reprint Interaction between ACE and ADD1 gene polymorphisms in the progression of IgA nephropathy in Japanese patients
    Ichiei Narita
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 757, Asahimachi Dori, Niigata, 951 8510, Japan
    Hypertension 42:304-9. 2003
  7. ncbi request reprint The genetic susceptibility to IgA nephropathy: a novel functional candidate gene for incomplete O-glycosylation of IgA1
    I Narita
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Kidney Int 71:379-81. 2007
  8. ncbi request reprint Role of genetic polymorphism in the SA gene on the blood pressure and prognosis of renal function in patients with immunoglobulin A nephropathy
    Ichiei Narita
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hypertens Res 25:831-6. 2002
  9. ncbi request reprint Etiology and prognostic significance of severe uremic pruritus in chronic hemodialysis patients
    I Narita
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Kidney Int 69:1626-32. 2006
  10. ncbi request reprint Genetic polymorphism of NPHS1 modifies the clinical manifestations of Ig A nephropathy
    Ichiei Narita
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi Dori, Niigata, Japan
    Lab Invest 83:1193-200. 2003

Collaborators

Detail Information

Publications93

  1. ncbi request reprint Uremic pruritus in chronic hemodialysis patients
    Ichiei Narita
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Nephrol 21:161-5. 2008
    ..Early diagnosis and treatment of uremic pruritus focusing on general strategies that include the optimization of dialysis dose, erythropoiesis-stimulating agents, and management of secondary hyperparathyroidism is recommended...
  2. pmc Distribution of amyloid deposits in the kidneys of a patient with reactive amyloidosis associated with rheumatoid arthritis
    Takeshi Kuroda
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City 951 8510, Japan
    BMC Res Notes 6:231. 2013
    ..Therefore, we describe the features of reactive amyloidosis associated with rheumatoid arthritis (RA) in an autopsied patient...
  3. pmc Significant association between renal function and amyloid-positive area in renal biopsy specimens in AL amyloidosis
    Takeshi Kuroda
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata City, 951 8510, Japan
    BMC Nephrol 13:118. 2012
    ..The correlation between amount of amyloid deposits and clinical parameters is not known. The aim of this study was to clarify correlation the amyloid area in all renal biopsy specimen and clinical parameters...
  4. pmc Henoch Schönlein purpura associated with pulmonary adenocarcinoma
    Daiki Mifune
    Department of Medicine II, Niigata University Medical and Dental Hospital, 951 8520 Niigata, Japan
    J Med Case Reports 5:226. 2011
    ..abstract:..
  5. pmc Clinical responses to EGFR-tyrosine kinase inhibitor retreatment in non-small cell lung cancer patients who benefited from prior effective gefitinib therapy: a retrospective analysis
    Satoshi Watanabe
    Department of Medicine, Niigata University Medical and Dental Hospital, Niigata City, Japan
    BMC Cancer 11:1. 2011
    ..The present study was conducted to evaluate the efficacy and toxicity of the 2(nd) EGFR-TKI administration...
  6. ncbi request reprint Interaction between ACE and ADD1 gene polymorphisms in the progression of IgA nephropathy in Japanese patients
    Ichiei Narita
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 757, Asahimachi Dori, Niigata, 951 8510, Japan
    Hypertension 42:304-9. 2003
    ..65, P=0.2902). These findings suggest an interaction between ACE and ADD1 polymorphisms not only on blood pressure regulation but also on the progression of renal dysfunction in patients with IgAN...
  7. ncbi request reprint The genetic susceptibility to IgA nephropathy: a novel functional candidate gene for incomplete O-glycosylation of IgA1
    I Narita
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Kidney Int 71:379-81. 2007
    ..Although underglycosylation was reported to be an acquired abnormality, genes for enzymes of O-glycosylation, such as C1GALT1, may be responsible for susceptibility to IgA nephropathy...
  8. ncbi request reprint Role of genetic polymorphism in the SA gene on the blood pressure and prognosis of renal function in patients with immunoglobulin A nephropathy
    Ichiei Narita
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hypertens Res 25:831-6. 2002
    ..Further, they suggest that the sensitivity to this gene polymorphism increases in patients with renal injury...
  9. ncbi request reprint Etiology and prognostic significance of severe uremic pruritus in chronic hemodialysis patients
    I Narita
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Kidney Int 69:1626-32. 2006
    ..Severe uremic pruritus caused by multiple factors, not only affects the quality of life but may also be associated with poor outcome in chronic hemodialysis patients...
  10. ncbi request reprint Genetic polymorphism of NPHS1 modifies the clinical manifestations of Ig A nephropathy
    Ichiei Narita
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi Dori, Niigata, Japan
    Lab Invest 83:1193-200. 2003
    ..This study suggests that the NPHS1 G349A polymorphism may be associated with heavy proteinuria and a decline in renal function in patients with IgAN...
  11. ncbi request reprint Identification of genes specifically expressed in chronic and progressive glomerulosclerosis
    I Narita
    Department of Medicine II, Niigata University Medical School, Japan
    Kidney Int Suppl 63:S215-7. 1997
    ..These genes may play important roles in the process which promotes acute glomerular damage advance to chronic and progressive glomerulosclerosis...
  12. ncbi request reprint Angiotensinogen gene variation and renoprotective efficacy of renin-angiotensin system blockade in IgA nephropathy
    Ichiei Narita
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Kidney Int 64:1050-8. 2003
    ..The interindividual variation in response to the RAS blockade may be in part genetically determined, whereas the results have been controversial...
  13. doi request reprint Pathogenetic significance of aberrant glycosylation of IgA1 in IgA nephropathy
    Ichiei Narita
    Department of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757, Asahimachi Dori, Niigata, 951 8510, Japan
    Clin Exp Nephrol 12:332-8. 2008
    ..This review will focus on and discuss the role of incompleteness of IgA1 O-galactosylation in the pathogenesis of IgAN and propose a possible mechanism in which abnormal IgA1 occurs in IgAN...
  14. ncbi request reprint Role of uteroglobin G38A polymorphism in the progression of IgA nephropathy in Japanese patients
    Ichiei Narita
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences 1 757, Asahimachi Dori, Niigata, 951 8510, Japan
    Kidney Int 61:1853-8. 2002
    ..A genetic polymorphism in uteroglobin has been reported to be associated with progression of IgA nephropathy in a Caucasian population, but the findings remain controversial...
  15. ncbi request reprint Genetic polymorphisms in the promoter and 5' UTR region of the Fc alpha receptor (CD89) are not associated with a risk of IgA nephropathy
    I Narita
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Japan
    J Hum Genet 46:694-8. 2001
    ..The present study indicates that the analyzed polymorphisms of the FcalphaR gene do not appear to be primarily involved in the susceptibility to IgAN...
  16. ncbi request reprint Transforming growth factor-beta1 gene polymorphism modifies the histological and clinical manifestations in Japanese patients with IgA nephropathy
    F Sato
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Tissue Antigens 64:35-42. 2004
    ..These results suggest that TGF-beta1 gene polymorphisms are specifically associated with heavy proteinuria and mesangial cell proliferation in Japanese patients with IgAN, although they do not confer susceptibility to this disease...
  17. ncbi request reprint Association of gene polymorphism of polymeric immunoglobulin receptor and IgA nephropathy
    I Narita
    Department of Medicine II, Niigata University Medical School
    Intern Med 40:867-72. 2001
    ....
  18. ncbi request reprint Peroxisome proliferator-activated receptor gamma C161T polymorphisms and survival of Japanese patients with immunoglobulin A nephropathy
    J Song
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi Dori, Niigata, Japan
    Clin Genet 64:398-403. 2003
    ..We report that the PPARG C161T polymorphism is associated with the survival of IgAN patients without hypertension. The T allele of the polymorphism might have a protective effect on the progression of IgAN...
  19. ncbi request reprint The combined genotypes of stimulatory and inhibitory Fc gamma receptors associated with systemic lupus erythematosus and periodontitis in Japanese adults
    Tetsuo Kobayashi
    Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Periodontol 78:467-74. 2007
    ..Therefore, we evaluated whether the combination of FcgammaR or IL-1 polymorphic genes represents a common risk factor for SLE and periodontitis...
  20. ncbi request reprint Maxacalcitol therapy decreases circulating osteoprotegerin levels in dialysis patients with secondary hyperparathyroidism
    J J Kazama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Clin Nephrol 64:64-8. 2005
    ..Little is known about the effects of vitamin D therapy on the circulating osteoprotegerin levels in dialysis patients...
  21. ncbi request reprint Expression of allograft inflammatory factor-1 in kidneys: A novel molecular component of podocyte
    Y Tsubata
    Department of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Kidney Int 70:1948-54. 2006
    ....
  22. ncbi request reprint Down-regulation of interferon-gamma signaling by gene transfer of Stat1 mutant in mesangial cells
    M Sakatsume
    Department of Medicine II and Research Laboratory for Molecular Genetics, Niigata University School of Medicine, Niigata, Japan
    Kidney Int 57:455-63. 2000
    ..We investigated Stat1alpha activation by IFN-gamma in mesangial cells and attempted to regulate the signal transduction by gene transfer...
  23. ncbi request reprint Risk of periodontitis in systemic lupus erythematosus is associated with Fcgamma receptor polymorphisms
    Tetsuo Kobayashi
    Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Periodontol 74:378-84. 2003
    ..The aim of this study was therefore to evaluate whether FcgammaR gene polymorphisms are associated with periodontitis risk in SLE patients...
  24. ncbi request reprint The circadian blood pressure rhythm in non-diabetic hemodialysis patients
    I Narita
    Department of Medicine II, Niigata University School of Medicine, Japan
    Hypertens Res 24:111-7. 2001
    ..The increased dRen observed only in ID patients may reflect occult cardiovascular damage or functional disturbances in aortic and carotid baroreflexes caused by arterial structural changes...
  25. ncbi request reprint Human glomerulonephritis accompanied by active cellular infiltrates shows effector T cells in urine
    M Sakatsume
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Am Soc Nephrol 12:2636-44. 2001
    ..These findings suggest that the appearance of effector T cells in urine may reflect the cellular immune reaction that occurs in the kidneys of patients with GN accompanied by active cell infiltration...
  26. ncbi request reprint Pretreatment plasma intact parathyroid hormone and serum calcium levels, but not serum phosphate levels, predict the response to maxacalcitol therapy in dialysis patients with secondary hyperparathyroidism
    Yuko Oyama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 751 Asahimachi dori, Niigata 951 8510, Japan
    Clin Exp Nephrol 9:142-7. 2005
    ..More evidence is needed to avoid the aimless continuation of active vitamin D therapy...
  27. ncbi request reprint SAA1 gene polymorphisms and the risk of AA amyloidosis in Japanese patients with rheumatoid arthritis
    Junya Ajiro
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, 951 8510, Japan
    Mod Rheumatol 16:294-9. 2006
    ..Both C-13T and C2995T were associated with the development of amyloidosis. Examining both polymorphisms may be more useful than examining only one of them for estimating the risk of the development of amyloidosis...
  28. ncbi request reprint Patients undergoing dialysis therapy for 30 years or more survive with serious osteoarticular disorders
    S Yamamoto
    Division of Clinical Nephrology and Rheumatology, Niigata University Medical and Dental Hospital, Niigata, Japan
    Clin Nephrol 70:496-502. 2008
    ..The aim of the study was to investigate the characteristics, such as dialysis-related complications, in chronic kidney disease (CKD) Stage 5D patients undergoing dialysis therapy for more than 30 years or more...
  29. ncbi request reprint [Gene polymorphisms of renin-angiotensin system in patients with kidney diseases]
    Ichiei Narita
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences
    Nihon Rinsho 62:1811-5. 2004
    ....
  30. ncbi request reprint Development of hungry bone syndrome after rapid lowering of PTH with intravenous maxacalcitol therapy in a patient with non-uremic secondary hyperparathyroidism
    J J Kazama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata University Medical Hospital, Niigata, Japan
    Clin Nephrol 60:369-71. 2003
    ..In conclusion, maxacalcitol therapy satisfactorily suppressed parathyroid function in a patient with secondary hyperparathyroidism without uremia. Appropriate Ca supplementation was required to perform it safely...
  31. doi request reprint Recent progress in understanding dialysis-related amyloidosis
    Suguru Yamamoto
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Science, Niigata, 951 8510, Japan
    Bone 45:S39-42. 2009
    ..DRA is one of the most harmful osteoarticular complications with regard to the maintenance of daily activities and quality of life in patients undergoing long-term dialysis therapy, in addition to the classical complications of CKD-MBD...
  32. ncbi request reprint Monocyte chemoattractant protein-1 A-2518G gene polymorphism and renal survival of Japanese patients with immunoglobulin A nephropathy
    Honami Mori
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Clin Exp Nephrol 9:297-303. 2005
    ..However, the correlation of MCP-1 gene polymorphism with the long-term prognosis of Japanese patients with IgAN has not been clearly determined yet...
  33. doi request reprint Effective anti-TNF-alpha therapy can induce rapid resolution and sustained decrease of gastroduodenal mucosal amyloid deposits in reactive amyloidosis associated with rheumatoid arthritis
    Takeshi Kuroda
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Cyuo ku, Niigata, Japan
    J Rheumatol 36:2409-15. 2009
    ..To examine the effect of anti-tumor necrosis factor-alpha (anti-TNF) therapy in patients with reactive AA amyloidosis associated with rheumatoid arthritis (RA)...
  34. doi request reprint Alterations in serum phosphate levels predict the long-term response to intravenous calcitriol therapy in dialysis patients with secondary hyperparathyroidism
    Kiyoko Hosaka
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 751 Asahimachi dori, Niigata, Niigata 951 8510, Japan
    J Bone Miner Metab 26:185-90. 2008
    ..Changes in treatment are recommended if patients show unsatisfactory parathyroid suppression with a hyperphosphatemic tendency...
  35. ncbi request reprint SM22alpha: the novel phenotype marker of injured glomerular epithelial cells in anti-glomerular basement membrane nephritis
    Asa Ogawa
    Division of Clinical Nephrology and Rheumatology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Nephron Exp Nephrol 106:e77-87. 2007
    ..SM22alpha is a 22-kDa cytoskeletal protein that is exclusively expressed in smooth muscle cells. We investigated the localization of SM22alpha at mRNA and protein levels, and its pathological significance in anti-GBM nephritis kidneys...
  36. ncbi request reprint Circulating osteoprotegerin affects bone metabolism in dialysis patients with mild secondary hyperparathyroidism
    Junichiro James Kazama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Ther Apher Dial 10:262-6. 2006
    ..Circulating OPG might have a suppressive effect on osteoclastic bone resorption in dialysis patients...
  37. ncbi request reprint Macrophage metalloelastase as a major factor for glomerular injury in anti-glomerular basement membrane nephritis
    Yoshikatsu Kaneko
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences and Kidney Center, Shinraku en Hospital, Niigata, Japan
    J Immunol 170:3377-85. 2003
    ..These results disclosed that MMP-12 played an important role in glomerular injury in a crescentic glomerulonephritis model, and inhibition of MMP-12 may lead to a new therapeutic strategy for this disease...
  38. ncbi request reprint Rapid and sensitive electrophoresis of urinary protein clearly reveals the pathophysiological feature of renal diseases
    Minoru Sakatsume
    Division of Clinical Nephrology and Rheumatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Nephrology (Carlton) 12:191-6. 2007
    ..However, this method has not been used routinely because of its difficulty in obtaining a clear image. This study was performed in order to re-evaluate this method with an improved system...
  39. ncbi request reprint Maxacalcitol is a possible less phosphatemic vitamin D analog
    Junichiro J Kazama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Ther Apher Dial 9:352-4. 2005
    ..05). Thus, maxacalcitol is a possible less phosphatemic active vitamin D agent, if not non-phosphatemic agent, which might reduce the risk of extraskeletal calcification...
  40. ncbi request reprint Histological differences in new-onset IgA nephropathy between children and adults
    Yohei Ikezumi
    Department of Pediatrics, Niigata University Medical and Dental Hospital, Asahimachi Dori, Niigata 951 8510, Japan
    Nephrol Dial Transplant 21:3466-74. 2006
    ..We addressed this question by comparing both histology and leucocyte accumulation in biopsies of recently diagnosed childhood and adult IgAN...
  41. ncbi request reprint A(-20)C polymorphism of the angiotensinogen gene and progression of IgA nephropathy
    Shin Goto
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1 757, Niigata 951 8510, Japan
    Kidney Int 62:980-5. 2002
    ..Recent studies showed that nucleotide substitution in the 5' upstream core promoter region of AGT affects the basal transcription rate of the gene...
  42. ncbi request reprint The interleukin-1 and Fcgamma receptor gene polymorphisms in Japanese patients with rheumatoid arthritis and periodontitis
    Tetsuo Kobayashi
    Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Periodontol 78:2311-8. 2007
    ..Therefore, we evaluated whether the IL-1 and FcgammaR gene polymorphisms represent a common risk factor for RA and periodontitis...
  43. ncbi request reprint LCAT-dependent conversion of prebeta1-HDL into alpha-migrating HDL is severely delayed in hemodialysis patients
    Takashi Miida
    Division of Clinical Preventive Medicine, Department of Community Preventive Medicine, Niigata University, Graduate School of Medical and Dental Sciences, Japan
    J Am Soc Nephrol 14:732-8. 2003
    ..001). In conclusion, the LCAT-dependent conversion of prebeta1-HDL to alpha-migrating HDL is severely delayed in hemodialysis patients. The impaired catabolism of prebeta1-HDL may accelerate atherosclerosis in hemodialysis patients...
  44. doi request reprint Comparison of quantitative cancellous bone connectivity analyses at two- and three-dimensional levels in dialysis patients
    Junichiro James Kazama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 754 Asahimachi dori, Chuo Ku, Niigata, Niigata 951 8510, Japan
    Calcif Tissue Int 84:38-44. 2009
    ..Further studies will thus be needed to establish appropriate methods for assessing cancellous bone connectivity in clinical practice...
  45. ncbi request reprint A novel type of encephalopathy associated with mushroom Sugihiratake ingestion in patients with chronic kidney diseases
    Fumitake Gejyo
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Kidney Int 68:188-92. 2005
    ..While the exact etiology of this encephalopathy remained mysterious, we aimed to describe its clinical features...
  46. doi request reprint The risk of gallbladder stone formation is increased in patients with predialysis chronic kidney disease but not those undergoing chronic hemodialysis therapy
    Junichiro James Kazama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Nephron Clin Pract 111:c167-72. 2009
    ..It is unclear whether the prevalence of gallbladder stones (GBS) is higher in patients with chronic kidney disease (CKD)...
  47. ncbi request reprint Patient with diffuse mesangial and endocapillary proliferative glomerulonephritis with hypocomplementemia and elevated anti-streptolysin O treated with prednisolone, angiotensin-converting enzyme inhibitor, and angiotensin II receptor antagonist
    Satoshi Ito
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Clin Exp Nephrol 7:290-5. 2003
    ..It is possible that this use of an angiotensin converting-enzyme inhibitor and an angiotensin II receptor antagonist was effective in reducing the proteinuria in this patient...
  48. ncbi request reprint Current clinical and pathogenetic understanding of beta2-m amyloidosis in long-term haemodialysis patients
    Fumitake Gejyo
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi Dori, Japan
    Nephrology (Carlton) 8:S45-9. 2003
    ..However, proof is lacking that amyloid deposits are decreased by long-term use of dialysis techniques to eliminate beta2-m. More effective treatment procedures are needed...
  49. doi request reprint Effect of ciclesonide on bronchial asthma in athletes
    Toshiyuki Koya
    Division of Respiratory Medicine, Department of Homeostatic Regulation and Development, Course in Biological Functions and Medical Control, Niigata University, Graduate School of Medical and Dental Sciences, Niigata City, Niigata, Japan
    J Asthma 46:1032-6. 2009
    ....
  50. ncbi request reprint Intact PTH assay overestimates true 1-84 PTH levels after maxacalcitol therapy in dialysis patients with secondary hyperparathyroidism
    Junichiro J Kazama
    FJSIM, Division of Intensive Care Medicine, Niigata University Medical Hospital, 1 754 Asahimachi dori, Niigata, Niigata 951 8510, Japan
    Nephrol Dial Transplant 19:892-7. 2004
    ..Previous studies have shown that the results of these two PTH assays in dialysis patients are closely correlated...
  51. doi request reprint Identification of alternatively activated macrophages in new-onset paediatric and adult immunoglobulin A nephropathy: potential role in mesangial matrix expansion
    Yohei Ikezumi
    Department of Pediatrics, Niigata University Medical and Dental Hospital, Niigata 951 8510 Japan
    Histopathology 58:198-210. 2011
    ..Therefore, the aim of this study was to investigate whether M2 macrophages are present in new-onset IgAN and if they are related to pathological differences between paediatric and adult disease...
  52. ncbi request reprint A patient with severe hypercalcemia in multiple organ dysfunction syndrome: role of elevated circulating 1alpha,25(OH)2 vitamin D levels
    Junichiro James Kazama
    Division of Critical and Intensive Care Medicine, Niigata University Medical and Dental Hospital, Niigata, Japan
    J Bone Miner Res 25:1455-9. 2010
    ..Extrarenal activation of CYP27B1 seems to play a role in the development of hypercalcemia in this disease condition. Clinicians need to be aware that severe hypercalcemia may occur in MODS patients...
  53. ncbi request reprint The efficacy of tonsillectomy on long-term renal survival in patients with IgA nephropathy
    Yuansheng Xie
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Kidney Int 63:1861-7. 2003
    ..Little information has been available until now about the clinical efficacy of tonsillectomy on long-term renal survival of patients with idiopathic immunoglobulin A nephropathy (IgAN)...
  54. pmc Cancellous bone volume is an indicator for trabecular bone connectivity in dialysis patients
    Junichiro James Kazama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata, Japan
    Clin J Am Soc Nephrol 5:292-8. 2010
    ..The system measures cancellous bone volume (BV/TV) as a third major evaluation axis; however, the physiologic significance of BV/TV remains unclear...
  55. ncbi request reprint Mizoribine therapy in a patient with lupus nephritis: the association between mizoribine concentration and peritoneal dialysis
    Takeshi Kuroda
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Cyuuou ku, Niigata 951 8510, Japan
    Mod Rheumatol 20:296-300. 2010
    ..Treatment with MZR was safe and useful even while undergoing CAPD. Achieving optimal MZR blood concentration was important for treatment of SLE, even though the patient was in end-stage renal failure...
  56. ncbi request reprint Pretreatment serum FGF-23 levels predict the efficacy of calcitriol therapy in dialysis patients
    Junichiro J Kazama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Kidney Int 67:1120-5. 2005
    ..Fibroblast growth factor-23 (FGF-23) is a newly found circulating phosphaturic factor. Its circulating level is elevated in uremia...
  57. ncbi request reprint Direct comparison between two 1-84PTH assays in dialysis patients
    Junichiro J Kazama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Nephron Clin Pract 99:c8-12. 2005
    ..Today, two kinds of 1-84PTH assays are available in clinical practice. Few studies have directly compared the results of these assays in the same plasma...
  58. ncbi request reprint Circulating 1-84 PTH and large C-terminal PTH fragment levels in uremia
    Junichiro James Kazama
    Division of Clinical Nephrology and Intensive Care Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Clin Exp Nephrol 7:144-9. 2003
    ..The so-called "intact parathyroid hormone (iPTH)" assay detects large C-terminal PTH fragments that are lacking several N-terminal amino acid residues in addition to 1-84 PTH molecules...
  59. ncbi request reprint Abeta-2M-amyloidosis and related bone diseases
    Junichiro James Kazama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 754 Asahimachi dori, Niigata, 951 8510, Japan
    J Bone Miner Metab 24:182-4. 2006
    ..The precise cell biological mechanism of this inflammatory change is unknown. Further studies are needed to establish specific treatments against this as yet unsolved problem with long-term dialysis therapy...
  60. doi request reprint A case report of severe visceral beta2-microglobulin-derived amyloidosis without obvious joint symptoms or radiological findings in a chronic hemodialyzed patient with systemic lupus erythematosus
    Ryo Koda
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Nagaoka Red Cross Hospital, 1 757 Asahimachi dori, Chuo Ku, Niigata, Japan
    Ther Apher Dial 13:232-7. 2009
    ..It should be noted that prominent visceral Abeta2M amyloidosis can develop without any osteoarticular symptoms or radiological abnormalities in dialyzed patients undergoing prolonged glucocorticoid therapy...
  61. ncbi request reprint Association of the MCP-1 gene polymorphism A-2518G with carpal-tunnel syndrome in hemodialysis patients
    Kentaro Omori
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Japan
    Amyloid 9:175-82. 2002
    ..In conclusion, homozygosity for G at -2518 in the MCP-1 gene might be a candidate for the genetic marker of CTS development in Japanese hemodialysis patients...
  62. ncbi request reprint [IgA nephropathy--pathogenesis, pathophysiology, and therapy]
    Ichiei Narita
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences
    Nihon Rinsho 64:397-402. 2006
  63. ncbi request reprint Para-capillary electron-dense deposits reduce glomerular filtration in patients with primary glomerular diseases
    Sachiko Fukase
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 754 Asahimachi dori, Niigata 951 8510, Japan
    Clin Exp Nephrol 10:33-9. 2006
    ..Electron-dense deposits are often found around glomerular capillary lumens in patients with glomerulonephritis, forming a portion of the blood-urine barrier (BUB)...
  64. ncbi request reprint Collagenofibrotic glomerulopathy: clinicopathologic overview of a rare glomerular disease
    Bassam Alchi
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Am J Kidney Dis 49:499-506. 2007
    ..A definite diagnosis can be established when typical histological findings are supported by immunohistochemistry for specific collagen types and electron microscopy with special staining methods. No specific treatment is available...
  65. doi request reprint Serum cystatin C measured by a sol particle homogeneous immunoassay can accurately detect early impairment of renal function
    Hiroe Sato
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Clin Exp Nephrol 12:270-6. 2008
    ..A sol particle homogeneous immunoassay (SPIA) is a method to measure the serum cystatin C (cysC) level as a marker of the glomerular filtration rate (GFR). Recently, formulas to convert measured cysC to GFR have been developed...
  66. doi request reprint Two distinct FSGS lesions caused by distinct etiology confirmed in a single patient in pre- and post-transplantation
    Yumi Ito
    Divisions of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Clin Transplant 24:54-9. 2010
    ..8 g/d within two wk. We considered that the present case showed two distinct types of FSGS lesions--one because of VUR and the other because of cyclosporine arteriolopathy--in each native kidney and transplanted kidney...
  67. ncbi request reprint Mortality predictors after 10 years of dialysis: a prospective study of Japanese hemodialysis patients
    Junya Ajiro
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi Dori, Niigata, Japan
    Clin J Am Soc Nephrol 2:653-60. 2007
    ..This work aimed to examine the predictive value for death of various clinical variables after long-term hemodialysis (HD)...
  68. ncbi request reprint Combined radioguided parathyroidectomy and intravenous vitamin D therapy for the treatment of uraemic hyperparathyroidism
    Yuko Oyama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata University Medical Hospital, Japan
    Nephrol Dial Transplant 18:iii76-8. 2003
    ..Further study needs to elucidate whether this treatment strategy can improve the long-term prognosis of patients with secondary hyperparathyroidism..
  69. ncbi request reprint Short-term use of continuous positive airway pressure ameliorates glomerular hyperfiltration in patients with obstructive sleep apnoea syndrome
    Shin ichi Kinebuchi
    Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, 951 8510, Japan
    Clin Sci (Lond) 107:317-22. 2004
    ..001). OSAS patients were generally in a glomerular-hyperfiltrating condition that appeared to cause the renal findings associated with OSAS. CPAP might prevent nephropathy by ameliorating the glomerular hyperfiltration in OSAS patients...
  70. ncbi request reprint Bezafibrate suppresses rat antiglomerular basement membrane crescentic glomerulonephritis
    Daisuke Saga
    Division of Clinical Nephrology and Rheumatology, Department of Laboratory Medicine Niigata University Graduate School of Medical and Dental Sciences, Asahimachi Dori, Niigata, Japan
    Kidney Int 67:1821-9. 2005
    ..The regulatory effect of bezafibrate (BZF), a ligand for PPARalpha on glomerulonephritis was investigated using a rat anti-glomerular basement membrane (GBM) glomerulonephritis model...
  71. ncbi request reprint [Psoriasis]
    Ichiei Narita
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences
    Nihon Rinsho 62:617-9. 2004
  72. ncbi request reprint Successful perioperative blood purification therapy in patients with maintenance hemodialysis therapy who underwent living donor liver transplantation
    J J Kazama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Clin Nephrol 59:229-33. 2003
    ..The application of careful and aggressive blood purification therapy during the perioperative period is a key to successful LDLT in dialysis patients...
  73. ncbi request reprint Atherosclerosis is accelerated in patients with long-term well-controlled systemic lupus erythematosus (SLE)
    Hiroe Sato
    Niigata University Graduate School of Medical and Dental Sciences, Division of Nephrology and Rheumatology, 1 754 Asahimachi dori, Chuo Ku Niigata, Niigata 951 8510, Japan
    Clin Chim Acta 385:35-42. 2007
    ..It is uncertain whether atherosclerosis is accelerated in premenopausal and postmenopausal patients with long-term well-controlled systemic lupus erythematosus (SLE)...
  74. ncbi request reprint Osteopontin expression in acute renal allograft rejection
    Bassam Alchi
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Kidney Int 67:886-96. 2005
    ..Osteopontin (OPN) is a potent chemoattractant for mononuclear cells that is up-regulated in various inflammatory states of the kidney. The role of OPN and its expression in human renal allograft rejection are unknown...
  75. ncbi request reprint Renovascular hypertension: a unique cause of unilateral focal segmental glomerulosclerosis
    Bassam Alchi
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Japan
    Hypertens Res 29:203-7. 2006
    ..This case illustrates the heterogeneous effect of the renin-angiotensin system on either kidney in patients with renovascular hypertension due to unilateral renal artery stenosis...
  76. ncbi request reprint Adult onset anaphylactoid purpura with severe gastrointestinal involvement
    Kazumi Oshima
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata
    Intern Med 42:436-42. 2003
    ..Prophylactic use of fluconazole failed to prevent contraction of invasive mycosis. Finally, he suddenly suffered from diffuse cerebral hemorrhage. Postmortem examination revealed systemic invasive aspergillosis as the cause of death...
  77. ncbi request reprint Hypersensitivity to paraoxybenzoic Acid esters (parabens) in a dialysis patient
    Kiyoko Sato
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Nephron 92:728-9. 2002
    ..We concluded that the allergen in this patient was not heparin but parabens. Hypereosinophilia of unknown origin often occurs in dialysis patients. Such patients may be hypersensitive to parabens...
  78. ncbi request reprint Decreased levels of circulating alpha2-Heremans-Schmid glycoprotein/Fetuin-A (AHSG) in patients with rheumatoid arthritis
    Hiroe Sato
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences
    Intern Med 46:1685-91. 2007
    ..It is often considered as a potential mediator between chronic inflammation and cardiovascular diseases. The metabolism of AHSG in patients with rheumatoid arthritis (RA) is unknown...
  79. ncbi request reprint Natural saline-flush is sufficient to maintain patency of immobilized-urokinase double-lumen catheter used to provide temporary blood access for hemodialysis
    Yoshikatsu Kaneko
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Blood Purif 22:473-9. 2004
    ..Heparin-lock is conventionally used to maintain patency of the catheter, but the necessity of heparin-lock has not been determined yet...
  80. doi request reprint Acute renal failure as a complication of acquired hemophilia due to autoantibody to factor VIII
    Yasuhiro Otaki
    Division of Clinical Nephrology and Rheumatology, Division of Cell Biology, Niigata University Graduate School of Medical and Dental Sciences, 1 757Asahimachi dori, Niigata, 951 8510, Japan
    Clin Exp Nephrol 14:85-9. 2010
    ..The levels of aPTT and concentrations of factor VIII and factor VIII inhibitor were monitored during the subsequent follow-ups...
  81. doi request reprint Effects of IS-741, a synthetic anti-inflammatory agent, on bleomycin-induced lung injury in mice
    Yuichi Shimaoka
    Division of Respiratory Medicine, Graduate School of Medical and Dental Sciences, Niigata University, 1 757 Asahimachi dori, Chuo Ku, Niigata, 951 8510, Japan
    Lung 187:331-9. 2009
    ..Treatment with IS-741 had an inhibitory effect on BLM-induced lung injury and fibrosis via the repression of MCP-1 or cysLTs in this murine experimental model...
  82. ncbi request reprint Association of a single-nucleotide polymorphism in the immunoglobulin mu-binding protein 2 gene with immunoglobulin A nephropathy
    Shigeru Ohtsubo
    Human Genome Center, The Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
    J Hum Genet 50:30-5. 2005
    ..048), the amino acid change might influence a class switch to increase serum IgA levels, resulting in a higher risk of IgA nephropathy...
  83. ncbi request reprint Single-nucleotide polymorphisms in the class II region of the major histocompatibility complex in Japanese patients with immunoglobulin A nephropathy
    Fumihiro Akiyama
    Human Genome Center, The Institute of Medical Science, University of Tokyo, Japan
    J Hum Genet 47:532-8. 2002
    ..000001, odds ratio = 1.91 [95% confidence interval 1.46-2.49]); SNPs in other LD blocks were not. Our data imply that some haplotype of the HLA- DRA locus has an important role in the development of IgAN in Japanese patients...
  84. ncbi request reprint Prevalence of chronic kidney disease (CKD) in the Japanese general population predicted by the MDRD equation modified by a Japanese coefficient
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Clin Exp Nephrol 11:156-63. 2007
    ..However, to date, a nationwide epidemiological study has not been conducted yet to survey the CKD population...
  85. ncbi request reprint Association of single-nucleotide polymorphisms in the polymeric immunoglobulin receptor gene with immunoglobulin A nephropathy (IgAN) in Japanese patients
    Wataru Obara
    Human Genome Center, The Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Hum Genet 48:293-9. 2003
    ..Our results suggest that a gene associated with susceptibility to IgAN lies within or close to the PIGR gene locus on chromosome 1q in the Japanese population...
  86. pmc Association between single-nucleotide polymorphisms in selectin genes and immunoglobulin A nephropathy
    Takashi Takei
    Human Genome Center, The Institute of Medical Science, University of Tokyo, Tokyo Women s Medical University, Tokyo, Japan
    Am J Hum Genet 70:781-6. 2002
    ..67, P=.000016, odds ratio = 1.88 [95% CI 1.41--2.51]). Our results suggest that these eight SNPs in selectin genes may be useful for screening populations susceptible to the IgAN phenotype that involves interstitial infiltration...
  87. ncbi request reprint Estimation of glomerular filtration rate by the MDRD study equation modified for Japanese patients with chronic kidney disease
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Clin Exp Nephrol 11:41-50. 2007
    ..In the present study, the equations originally developed for a Caucasian population were tested in Japanese CKD patients, and modified with the Japanese coefficient determined by the data...
  88. ncbi request reprint Renal function at the time of renal biopsy as a predictor of prognosis in patients with primary AL-type amyloidosis
    Yutaka Osawa
    Shinrakuen Hospital, 1 27 Nishi Ariake, Niigata 950 2087, Japan
    Clin Exp Nephrol 8:127-33. 2004
    ....
  89. ncbi request reprint [Clinical nephrology]
    Yoshikatsu Kaneko
    Nihon Jinzo Gakkai Shi 49:19-24. 2007
  90. ncbi request reprint [Encephalopathy of unknown etiology with suspected involvement of Pleurocybella porrigens (Pers.:Fr.) Sing. 2. Pleurocybella porrigens-encephalopathy clustering among patients with kidney failure]
    Fumitake Gejo
    Nihon Naika Gakkai Zasshi 95:1310-5. 2006
  91. ncbi request reprint Identification of genes regulating colorectal carcinogenesis by using the algorithm for diagnosing malignant state method
    Yasushi Ichikawa
    Second Department of Surgery, School of Medicine, Yokohama City University, Yokohama, Japan
    Biochem Biophys Res Commun 296:497-506. 2002
    ..Included in the 135 genes were tumor suppressor and growth factor-related genes and were consistent with the literature. ADMS is a reliable means for identifying genes useful for the diagnosis of cancer...
  92. ncbi request reprint Relationship between tonsils and IgA nephropathy as well as indications of tonsillectomy
    Yuansheng Xie
    Kidney Center of PLA, Department of Nephrology, Chinese General Hospital of PLA, Beijing, China
    Kidney Int 65:1135-44. 2004
    ..However, tonsillectomy may not be enough and may not change the prognosis in IgAN patients with marked renal damage...
  93. ncbi request reprint [Medical networking to prevent kidney failure and life-time education: discussion]
    Kenjiro Kimura
    Nihon Naika Gakkai Zasshi 93:965-88. 2004