Affiliation: Niigata University
- Why does the autoantibody against granulocyte-macrophage colony-stimulating factor cause lesions only in the lung?Koh Nakata
Bioscience and Medical Research Center, Niigata University Medical and Dental Hospital, Asahimachi Dohri, Niigata, Japan
Respirology 11:S65-9. 2006..However, this finding posed the question as to why the autoantibody against GM-CSF caused lesions only in the lung...
- [Molecular pathogenesis in tuberculosis complicated with AIDS]Koh Nakata
Bioscience Medical Research Center, Niigata Medical Dental Hospital, Niigata, Japan
Kekkaku 79:659-67. 2004..Contact between activated lymphocytes and macrophages is necessary to downregulate inhibitory C/EBP beta, thereby derepressing the HIV-1 LTR. Lymphocyte derived soluble factor(s) activate NF-kappaB, further enhancing the HIV-1 LTR...
- Light chain (κ/λ) ratio of GM-CSF autoantibodies is associated with disease severity in autoimmune pulmonary alveolar proteinosisTakahito Nei
Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, Niigata, Japan Department of Respiratory Medicine, Nippon Medical School, Tokyo, Japan Electronic address
Clin Immunol 149:357-64. 2013..Thus, the light chain isotype usage of GMAb may not only be associated with the severity of aPAP, but may also represent a useful disease severity marker. ..
- IgM-type GM-CSF autoantibody is etiologically a bystander but associated with IgG-type autoantibody production in autoimmune pulmonary alveolar proteinosisTakahito Nei
Bioscience Medical Research Center, Niigata Univ Medical and Dental Hospital, Asahimachi Dori, Niigata, Japan
Am J Physiol Lung Cell Mol Physiol 302:L959-64. 2012..It rather may be involved in the mechanism for development of IgG-GMAb in vivo...
- Direct evidence that GM-CSF inhalation improves lung clearance in pulmonary alveolar proteinosisKazumasa Ohashi
Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, 1 754 Asahimachi dori, Niigata 951 8520, Japan
Respir Med 106:284-93. 2012..It is plausible that inhaled GM-CSF improves the dysfunction of alveolar macrophages and promotes the clearance of the surfactant. However, effect of the therapy on components in bronchoalveolar lavage fluid (BALF) remains unclear...
- Inhaled granulocyte/macrophage-colony stimulating factor as therapy for pulmonary alveolar proteinosisRyushi Tazawa
Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, 1 754 Asahimachi dori, Niigata, Japan
Am J Respir Crit Care Med 181:1345-54. 2010..Inhaled granulocyte/macrophage-colony stimulating factor (GM-CSF) is a promising therapy for pulmonary alveolar proteinosis (PAP) but has not been adequately studied...
- A cell-free assay to estimate the neutralizing capacity of granulocyte-macrophage colony-stimulating factor autoantibodiesShinya Urano
Niigata University Medical and Dental Hospital, Niigata, Japan
J Immunol Methods 360:141-8. 2010..Binding inhibition was correlated with growth inhibition of TF-1 cells, a GM-CSF dependent cell line. These results suggest that our cell-free system can be applied to estimate the neutralizing capacity of GM-CSF autoantibodies ex vivo...
- Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in JapanYoshikazu Inoue
Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, 754 Ichibannchoh, Asahimachi Tohri, Niigata 951 8520, Japan
Am J Respir Crit Care Med 177:752-62. 2008..Because PAP is rare, prior reports were based on limited patient numbers or a synthesis of historical data...
- Adult-onset hereditary pulmonary alveolar proteinosis caused by a single-base deletion in CSF2RBTakeshi Tanaka
Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
J Med Genet 48:205-9. 2011..Rarely, genetic defects in neonatal or infant-onset PAP have been identified in CSF2RA. However, no report has clearly identified any function-associated genetic defect in CSF2RB...
- Characterization of human cultured periosteal sheets expressing bone-forming potential: in vitro and in vivo animal studiesTomoyuki Kawase
Division of Oral Bioengineering, Department of Tissue Regeneration and Reconstitution, Institute of Medicine and Dentistry, Niigata University, Niigata, Japan
J Tissue Eng Regen Med 3:218-29. 2009..These two major characteristics indicate that a mature hCP sheet is a promising osteoinductive biomaterial, even without conventional scaffolds for periodontal regenerative therapy...
- Anti-cytokine autoantibodies are ubiquitous in healthy individualsMasato Watanabe
Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, Niigata 951 8520, Japan
FEBS Lett 581:2017-21. 2007..Autoantibodies against IL-4, IL-6, IL-10, and interferon-gamma were variously detected. Thus, we discovered that anti-cytokine autoantibodies to multiple cytokines are ubiquitous in healthy individuals...
- Reciprocal CD4+ T-cell balance of effector CD62Llow CD4+ and CD62LhighCD25+ CD4+ regulatory T cells in small cell lung cancer reflects disease stageKenichi Koyama
Division of Respiratory Medicine, Department of Homeostatic Regulation and Development, Course for Biological Functions and Medical Control, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
Clin Cancer Res 14:6770-9. 2008..The purpose of this study was to elucidate the immunologic balance induced in SCLC patients...
- Expression of PU.1 and terminal differentiation of alveolar macrophages in newborn ratsHaruko Iwabuchi
Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1 757, Niigata 951 8510, Japan
Cell Tissue Res 329:71-9. 2007..These results suggest that AMs are initially immature, and that their terminal differentiation starts after birth concomitantly with an increased expression of PU.1...
- Mechanisms of polymorphonuclear neutrophil-mediated induction of HIV-1 replication in macrophages during pulmonary tuberculosisYoshihiko Hoshino
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
J Infect Dis 195:1303-10. 2007....
- Serum antibody against granulocyte/macrophage colony-stimulating factor and KL-6 in idiopathic pulmonary alveolar proteinosisMasayuki Nara
Department of Infectious and Respiratory Diseases, Tohoku University School of Medicine, Sendai, Japan
Tohoku J Exp Med 208:349-54. 2006..On the contrary, KL-6 is an excellent marker for the assessment of the clinical course of I-PAP...
- Maximal HIV-1 replication in alveolar macrophages during tuberculosis requires both lymphocyte contact and cytokinesYoshihiko Hoshino
Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
J Exp Med 195:495-505. 2002..Contact between activated lymphocytes and macrophages is necessary to down-regulate inhibitory C/EBPbeta, thereby derepressing the HIV-1 LTR. Lymphocyte-derived cytokines activate NF-kappaB, further enhancing the HIV-1 LTR...
- Granulocyte-macrophage colony-stimulating factor inhalation therapy for patients with idiopathic pulmonary alveolar proteinosis: a pilot study; and long-term treatment with aerosolized granulocyte-macrophage colony-stimulating factor: a case reportRyushi Tazawa
Respiratory Medicine and Translational Research Clinic, Tohoku University Hospital, Seiryomachi, Sendai, Japan
Respirology 11:S61-4. 2006..The results suggest that the efficacy of GM-CSF inhalation therapy might be related to the drug preparation mode, choice of nebulizer, and duration of treatment...
- Epidemiological and clinical features of idiopathic pulmonary alveolar proteinosis in JapanYoshikazu Inoue
Department of Diffuse Lung Diseases and Respiratory Failure, Clinical Research Center, National Hospital Organization NHO Kinki Chuo Chest Medical Center, Sakai, Osaka, Japan
Respirology 11:S55-60. 2006..The combined measurements of the serum markers may well prove very useful for both the diagnosis and the management of IPAP patients...
- Granulocyte-macrophage colony-stimulating factor and lung immunity in pulmonary alveolar proteinosisRyushi Tazawa
Institute of Development, Aging, and Cancer, Tohoku University Department of Hematology and Immunology, Tohoku University Hospital, Japan
Am J Respir Crit Care Med 171:1142-9. 2005..Our study shows that GM-CSF administration engenders a decrease in the neutralizing capacity against the protein in the lungs. Thereby, it facilitates restoration of the normal function of alveolar macrophages...
- Serum neutralizing capacity of GM-CSF reflects disease severity in a patient with pulmonary alveolar proteinosis successfully treated with inhaled GM-CSFToru Arai
Department of Medicine, National Hospital Organization Kinki chuo Chest Medical Center, Sakai, Osaka 591 8555, Japan
Respir Med 98:1227-30. 2004....
- Pulmonary alveolar proteinosisJeffrey J Presneill
Intensive Care Unit, Royal Melbourne Hospital, Grattan Street, Parkville 3050, Victoria, Australia
Clin Chest Med 25:593-613, viii. 2004..The last decade has brought new advances in laboratory and clinical research that are lifting a veil not only on PAP but also on general aspects of pulmonary surfactant biology and innate immune defense...
- High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosisKanji Uchida
Department of Respiratory Diseases, Research Institute, International Medical Center of Japan, 1 21 1 Toyama, Shinjuku City, Tokyo 162 8655, Japan
Blood 103:1089-98. 2004..Our data strengthen the evidence associating anti-GM-CSF autoantibodies with the pathogenesis of this disease...
- Pulmonary alveolar proteinosisBruce C Trapnell
Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
N Engl J Med 349:2527-39. 2003
- [The mechanism of HIV replication at the site of inflammation coinfected with HIV and M. tuberculosis]Koh Nakata
Department of Respiratory Diseases, Research Institute, International Medical Center of Japan, 1 21 1, Toyama, Shinjuku ku, Tokyo 162 8655, Japan
Kekkaku 77:687-92. 2002..Contact between activated lymphocytes and macrophages is necessary to down-regulate inhibitory C/EBP beta, thereby derepressing the HIV-1 LTR. Lymphocyte derived soluble factor(s) activate NF-kappa B, further enhancing the HIV-LTR...
- Secondary pulmonary alveolar proteinosis associated with myelodysplastic syndromeTetsuro Ohnishi
Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo
Intern Med 42:187-90. 2003..Autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF) in sera were below sensitivity, while the GM-CSF level was elevated in bronchoalveolar lavage fluid. He was diagnosed as secondary PAP associated with MDS...
- BCL-6 mutations in pulmonary lymphoproliferative disorders: demonstration of an aberrant immunological reaction in HIV-related lymphoid interstitial pneumoniaKatsushi Kurosu
Department of Respirology B2, Graduate School of Medicine, Chiba University, Chiba, Japan
J Immunol 172:7116-22. 2004....
- A case of idiopathic pulmonary alveolar proteinosis accompanied by T-cell receptor gene rearrangement in bronchoalveolar lavage fluid cellsTakeshi Hosokawa
First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Hokkaido, Japan
Respirology 9:286-8. 2004..We speculate that monoclonal expansion of a T-cell population may play a role in the production of anti-GM-CSF antibody and the development of PAP...
- A combination therapy of whole lung lavage and GM-CSF inhalation in pulmonary alveolar proteinosisHajime Yamamoto
Department of Pediatrics, Aichi Medical University School of Medicine, Aichi, Japan
Pediatr Pulmonol 43:828-30. 2008..Unilateral WLL was performed three times and subsequent GM-CSF inhalation therapy yielded marked physiological and radiological improvement and was continued for 1 year...
- Propionibacterium acnes is the most common bacterium commensal in peripheral lung tissue and mediastinal lymph nodes from subjects without sarcoidosisIkuo Ishige
Department of Human Pathology, Tokyo Medical and Dental University, Tokyo, Japan
Sarcoidosis Vasc Diffuse Lung Dis 22:33-42. 2005..P. acnes might be commensal not only to the skin, conjunctivae, and intestine, but also to the lungs and lymph nodes of individuals without sarcoidosis...
- Successful treatment of congenital pulmonary alveolar proteinosis with intravenous immunoglobulin G administrationKazutoshi Cho
Maternity and Perinatal Care Center, Hokkaido University Hospital, Hokkaido, Sapporo, Japan
Respirology 11:S74-7. 2006..In a flow cytometric study, IgM was expressed on the cell surface. In conclusion, an abnormality in a single gene may have decreased secretion of immunoglobulin from the B cells and the AM phagocytotic activity in the patient...