Koh Nakata

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. ncbi request reprint Why does the autoantibody against granulocyte-macrophage colony-stimulating factor cause lesions only in the lung?
    Koh Nakata
    Bioscience and Medical Research Center, Niigata University Medical and Dental Hospital, Asahimachi Dohri, Niigata, Japan
    Respirology 11:S65-9. 2006
  2. ncbi request reprint [Molecular pathogenesis in tuberculosis complicated with AIDS]
    Koh Nakata
    Bioscience Medical Research Center, Niigata Medical Dental Hospital, Niigata, Japan
    Kekkaku 79:659-67. 2004
  3. doi request reprint Light chain (κ/λ) ratio of GM-CSF autoantibodies is associated with disease severity in autoimmune pulmonary alveolar proteinosis
    Takahito Nei
    Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, Niigata, Japan Department of Respiratory Medicine, Nippon Medical School, Tokyo, Japan Electronic address
    Clin Immunol 149:357-64. 2013
  4. doi request reprint IgM-type GM-CSF autoantibody is etiologically a bystander but associated with IgG-type autoantibody production in autoimmune pulmonary alveolar proteinosis
    Takahito Nei
    Bioscience Medical Research Center, Niigata Univ Medical and Dental Hospital, Asahimachi Dori, Niigata, Japan
    Am J Physiol Lung Cell Mol Physiol 302:L959-64. 2012
  5. doi request reprint Direct evidence that GM-CSF inhalation improves lung clearance in pulmonary alveolar proteinosis
    Kazumasa Ohashi
    Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, 1 754 Asahimachi dori, Niigata 951 8520, Japan
    Respir Med 106:284-93. 2012
  6. pmc Inhaled granulocyte/macrophage-colony stimulating factor as therapy for pulmonary alveolar proteinosis
    Ryushi Tazawa
    Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, 1 754 Asahimachi dori, Niigata, Japan
    Am J Respir Crit Care Med 181:1345-54. 2010
  7. ncbi request reprint Low concentrations of recombinant granulocyte macrophage-colony stimulating factor derived from Chinese hamster ovary cells augments long-term bioactivity with delayed clearance in vitro
    Atsushi Hashimoto
    Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, 1 754, Asahimachi Dori, Chuo Ku, Niigata 951 8510, Japan Electronic address
    Cytokine 68:118-26. 2014
  8. doi request reprint A cell-free assay to estimate the neutralizing capacity of granulocyte-macrophage colony-stimulating factor autoantibodies
    Shinya Urano
    Niigata University Medical and Dental Hospital, Niigata, Japan
    J Immunol Methods 360:141-8. 2010
  9. pmc Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan
    Yoshikazu Inoue
    Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, 754 Ichibannchoh, Asahimachi Tohri, Niigata 951 8520, Japan
    Am J Respir Crit Care Med 177:752-62. 2008
  10. doi request reprint Characterization of human cultured periosteal sheets expressing bone-forming potential: in vitro and in vivo animal studies
    Tomoyuki Kawase
    Division of Oral Bioengineering, Department of Tissue Regeneration and Reconstitution, Institute of Medicine and Dentistry, Niigata University, Niigata, Japan
    J Tissue Eng Regen Med 3:218-29. 2009

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Why does the autoantibody against granulocyte-macrophage colony-stimulating factor cause lesions only in the lung?
    Koh Nakata
    Bioscience and Medical Research Center, Niigata University Medical and Dental Hospital, Asahimachi Dohri, Niigata, Japan
    Respirology 11:S65-9. 2006
    ..However, this finding posed the question as to why the autoantibody against GM-CSF caused lesions only in the lung...
  2. ncbi request reprint [Molecular pathogenesis in tuberculosis complicated with AIDS]
    Koh Nakata
    Bioscience Medical Research Center, Niigata Medical Dental Hospital, Niigata, Japan
    Kekkaku 79:659-67. 2004
    ..Contact between activated lymphocytes and macrophages is necessary to downregulate inhibitory C/EBP beta, thereby derepressing the HIV-1 LTR. Lymphocyte derived soluble factor(s) activate NF-kappaB, further enhancing the HIV-1 LTR...
  3. doi request reprint Light chain (κ/λ) ratio of GM-CSF autoantibodies is associated with disease severity in autoimmune pulmonary alveolar proteinosis
    Takahito Nei
    Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, Niigata, Japan Department of Respiratory Medicine, Nippon Medical School, Tokyo, Japan Electronic address
    Clin Immunol 149:357-64. 2013
    ..Thus, the light chain isotype usage of GMAb may not only be associated with the severity of aPAP, but may also represent a useful disease severity marker. ..
  4. doi request reprint IgM-type GM-CSF autoantibody is etiologically a bystander but associated with IgG-type autoantibody production in autoimmune pulmonary alveolar proteinosis
    Takahito Nei
    Bioscience Medical Research Center, Niigata Univ Medical and Dental Hospital, Asahimachi Dori, Niigata, Japan
    Am J Physiol Lung Cell Mol Physiol 302:L959-64. 2012
    ..It rather may be involved in the mechanism for development of IgG-GMAb in vivo...
  5. doi request reprint Direct evidence that GM-CSF inhalation improves lung clearance in pulmonary alveolar proteinosis
    Kazumasa Ohashi
    Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, 1 754 Asahimachi dori, Niigata 951 8520, Japan
    Respir Med 106:284-93. 2012
    ..It is plausible that inhaled GM-CSF improves the dysfunction of alveolar macrophages and promotes the clearance of the surfactant. However, effect of the therapy on components in bronchoalveolar lavage fluid (BALF) remains unclear...
  6. pmc Inhaled granulocyte/macrophage-colony stimulating factor as therapy for pulmonary alveolar proteinosis
    Ryushi Tazawa
    Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, 1 754 Asahimachi dori, Niigata, Japan
    Am J Respir Crit Care Med 181:1345-54. 2010
    ..Inhaled granulocyte/macrophage-colony stimulating factor (GM-CSF) is a promising therapy for pulmonary alveolar proteinosis (PAP) but has not been adequately studied...
  7. ncbi request reprint Low concentrations of recombinant granulocyte macrophage-colony stimulating factor derived from Chinese hamster ovary cells augments long-term bioactivity with delayed clearance in vitro
    Atsushi Hashimoto
    Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, 1 754, Asahimachi Dori, Chuo Ku, Niigata 951 8510, Japan Electronic address
    Cytokine 68:118-26. 2014
    ..These results suggest that sialylation of oligosaccharide moieties delayed the clearance of GM-CSF, thus eliciting increased long-term bioactivity in vitro. ..
  8. doi request reprint A cell-free assay to estimate the neutralizing capacity of granulocyte-macrophage colony-stimulating factor autoantibodies
    Shinya Urano
    Niigata University Medical and Dental Hospital, Niigata, Japan
    J Immunol Methods 360:141-8. 2010
    ..Binding inhibition was correlated with growth inhibition of TF-1 cells, a GM-CSF dependent cell line. These results suggest that our cell-free system can be applied to estimate the neutralizing capacity of GM-CSF autoantibodies ex vivo...
  9. pmc Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan
    Yoshikazu Inoue
    Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, 754 Ichibannchoh, Asahimachi Tohri, Niigata 951 8520, Japan
    Am J Respir Crit Care Med 177:752-62. 2008
    ..Because PAP is rare, prior reports were based on limited patient numbers or a synthesis of historical data...
  10. doi request reprint Characterization of human cultured periosteal sheets expressing bone-forming potential: in vitro and in vivo animal studies
    Tomoyuki Kawase
    Division of Oral Bioengineering, Department of Tissue Regeneration and Reconstitution, Institute of Medicine and Dentistry, Niigata University, Niigata, Japan
    J Tissue Eng Regen Med 3:218-29. 2009
    ..These two major characteristics indicate that a mature hCP sheet is a promising osteoinductive biomaterial, even without conventional scaffolds for periodontal regenerative therapy...
  11. doi request reprint Adult-onset hereditary pulmonary alveolar proteinosis caused by a single-base deletion in CSF2RB
    Takeshi Tanaka
    Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
    J Med Genet 48:205-9. 2011
    ..Rarely, genetic defects in neonatal or infant-onset PAP have been identified in CSF2RA. However, no report has clearly identified any function-associated genetic defect in CSF2RB...
  12. pmc Secondary pulmonary alveolar proteinosis complicating myelodysplastic syndrome results in worsening of prognosis: a retrospective cohort study in Japan
    Haruyuki Ishii
    Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, 1 754 Asahimachi dori, Chuo Ku, Niigata 9518520, Japan
    BMC Pulm Med 14:37. 2014
    ..However, the impact of sPAP on the prognosis of underlying MDS remains unknown. The purpose of this study was to evaluate whether development of sPAP worsens the prognosis of MDS...
  13. ncbi request reprint Anti-cytokine autoantibodies are ubiquitous in healthy individuals
    Masato Watanabe
    Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, Niigata 951 8520, Japan
    FEBS Lett 581:2017-21. 2007
    ..Autoantibodies against IL-4, IL-6, IL-10, and interferon-gamma were variously detected. Thus, we discovered that anti-cytokine autoantibodies to multiple cytokines are ubiquitous in healthy individuals...
  14. doi request reprint Reciprocal CD4+ T-cell balance of effector CD62Llow CD4+ and CD62LhighCD25+ CD4+ regulatory T cells in small cell lung cancer reflects disease stage
    Kenichi Koyama
    Division of Respiratory Medicine, Department of Homeostatic Regulation and Development, Course for Biological Functions and Medical Control, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Clin Cancer Res 14:6770-9. 2008
    ..The purpose of this study was to elucidate the immunologic balance induced in SCLC patients...
  15. ncbi request reprint Expression of PU.1 and terminal differentiation of alveolar macrophages in newborn rats
    Haruko Iwabuchi
    Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1 757, Niigata 951 8510, Japan
    Cell Tissue Res 329:71-9. 2007
    ..These results suggest that AMs are initially immature, and that their terminal differentiation starts after birth concomitantly with an increased expression of PU.1...
  16. ncbi request reprint Mechanisms of polymorphonuclear neutrophil-mediated induction of HIV-1 replication in macrophages during pulmonary tuberculosis
    Yoshihiko Hoshino
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Infect Dis 195:1303-10. 2007
    ....
  17. ncbi request reprint Serum antibody against granulocyte/macrophage colony-stimulating factor and KL-6 in idiopathic pulmonary alveolar proteinosis
    Masayuki Nara
    Department of Infectious and Respiratory Diseases, Tohoku University School of Medicine, Sendai, Japan
    Tohoku J Exp Med 208:349-54. 2006
    ..On the contrary, KL-6 is an excellent marker for the assessment of the clinical course of I-PAP...
  18. pmc Maximal HIV-1 replication in alveolar macrophages during tuberculosis requires both lymphocyte contact and cytokines
    Yoshihiko Hoshino
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Exp Med 195:495-505. 2002
    ..Contact between activated lymphocytes and macrophages is necessary to down-regulate inhibitory C/EBPbeta, thereby derepressing the HIV-1 LTR. Lymphocyte-derived cytokines activate NF-kappaB, further enhancing the HIV-1 LTR...
  19. ncbi request reprint High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis
    Kanji Uchida
    Department of Respiratory Diseases, Research Institute, International Medical Center of Japan, 1 21 1 Toyama, Shinjuku City, Tokyo 162 8655, Japan
    Blood 103:1089-98. 2004
    ..Our data strengthen the evidence associating anti-GM-CSF autoantibodies with the pathogenesis of this disease...
  20. ncbi request reprint Pulmonary alveolar proteinosis
    Bruce C Trapnell
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    N Engl J Med 349:2527-39. 2003
  21. ncbi request reprint Pulmonary alveolar proteinosis
    Jeffrey J Presneill
    Intensive Care Unit, Royal Melbourne Hospital, Grattan Street, Parkville 3050, Victoria, Australia
    Clin Chest Med 25:593-613, viii. 2004
    ..The last decade has brought new advances in laboratory and clinical research that are lifting a veil not only on PAP but also on general aspects of pulmonary surfactant biology and innate immune defense...
  22. ncbi request reprint Serum neutralizing capacity of GM-CSF reflects disease severity in a patient with pulmonary alveolar proteinosis successfully treated with inhaled GM-CSF
    Toru Arai
    Department of Medicine, National Hospital Organization Kinki chuo Chest Medical Center, Sakai, Osaka 591 8555, Japan
    Respir Med 98:1227-30. 2004
    ....
  23. ncbi request reprint Granulocyte-macrophage colony-stimulating factor and lung immunity in pulmonary alveolar proteinosis
    Ryushi Tazawa
    Institute of Development, Aging, and Cancer, Tohoku University Department of Hematology and Immunology, Tohoku University Hospital, Japan
    Am J Respir Crit Care Med 171:1142-9. 2005
    ..Our study shows that GM-CSF administration engenders a decrease in the neutralizing capacity against the protein in the lungs. Thereby, it facilitates restoration of the normal function of alveolar macrophages...
  24. ncbi request reprint Epidemiological and clinical features of idiopathic pulmonary alveolar proteinosis in Japan
    Yoshikazu Inoue
    Department of Diffuse Lung Diseases and Respiratory Failure, Clinical Research Center, National Hospital Organization NHO Kinki Chuo Chest Medical Center, Sakai, Osaka, Japan
    Respirology 11:S55-60. 2006
    ..The combined measurements of the serum markers may well prove very useful for both the diagnosis and the management of IPAP patients...
  25. ncbi request reprint Granulocyte-macrophage colony-stimulating factor inhalation therapy for patients with idiopathic pulmonary alveolar proteinosis: a pilot study; and long-term treatment with aerosolized granulocyte-macrophage colony-stimulating factor: a case report
    Ryushi Tazawa
    Respiratory Medicine and Translational Research Clinic, Tohoku University Hospital, Seiryomachi, Sendai, Japan
    Respirology 11:S61-4. 2006
    ..The results suggest that the efficacy of GM-CSF inhalation therapy might be related to the drug preparation mode, choice of nebulizer, and duration of treatment...
  26. doi request reprint A combination therapy of whole lung lavage and GM-CSF inhalation in pulmonary alveolar proteinosis
    Hajime Yamamoto
    Department of Pediatrics, Aichi Medical University School of Medicine, Aichi, Japan
    Pediatr Pulmonol 43:828-30. 2008
    ..Unilateral WLL was performed three times and subsequent GM-CSF inhalation therapy yielded marked physiological and radiological improvement and was continued for 1 year...
  27. ncbi request reprint Propionibacterium acnes is the most common bacterium commensal in peripheral lung tissue and mediastinal lymph nodes from subjects without sarcoidosis
    Ikuo Ishige
    Department of Human Pathology, Tokyo Medical and Dental University, Tokyo, Japan
    Sarcoidosis Vasc Diffuse Lung Dis 22:33-42. 2005
    ..P. acnes might be commensal not only to the skin, conjunctivae, and intestine, but also to the lungs and lymph nodes of individuals without sarcoidosis...
  28. ncbi request reprint A case of idiopathic pulmonary alveolar proteinosis accompanied by T-cell receptor gene rearrangement in bronchoalveolar lavage fluid cells
    Takeshi Hosokawa
    First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Hokkaido, Japan
    Respirology 9:286-8. 2004
    ..We speculate that monoclonal expansion of a T-cell population may play a role in the production of anti-GM-CSF antibody and the development of PAP...
  29. ncbi request reprint BCL-6 mutations in pulmonary lymphoproliferative disorders: demonstration of an aberrant immunological reaction in HIV-related lymphoid interstitial pneumonia
    Katsushi Kurosu
    Department of Respirology B2, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Immunol 172:7116-22. 2004
    ....
  30. ncbi request reprint Secondary pulmonary alveolar proteinosis associated with myelodysplastic syndrome
    Tetsuro Ohnishi
    Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo
    Intern Med 42:187-90. 2003
    ..Autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF) in sera were below sensitivity, while the GM-CSF level was elevated in bronchoalveolar lavage fluid. He was diagnosed as secondary PAP associated with MDS...
  31. ncbi request reprint [The mechanism of HIV replication at the site of inflammation coinfected with HIV and M. tuberculosis]
    Koh Nakata
    Department of Respiratory Diseases, Research Institute, International Medical Center of Japan, 1 21 1, Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    Kekkaku 77:687-92. 2002
    ..Contact between activated lymphocytes and macrophages is necessary to down-regulate inhibitory C/EBP beta, thereby derepressing the HIV-1 LTR. Lymphocyte derived soluble factor(s) activate NF-kappa B, further enhancing the HIV-LTR...
  32. ncbi request reprint Successful treatment of congenital pulmonary alveolar proteinosis with intravenous immunoglobulin G administration
    Kazutoshi Cho
    Maternity and Perinatal Care Center, Hokkaido University Hospital, Hokkaido, Sapporo, Japan
    Respirology 11:S74-7. 2006
    ..In a flow cytometric study, IgM was expressed on the cell surface. In conclusion, an abnormality in a single gene may have decreased secretion of immunoglobulin from the B cells and the AM phagocytotic activity in the patient...