T Nakada

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. ncbi request reprint Brain developmental abnormalities in Prader-Willi syndrome detected by diffusion tensor imaging
    Kenichi Yamada
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Asahimachi 1 757, Niigata, 951 8585, Japan
    Pediatrics 118:e442-8. 2006
  2. doi request reprint Expansion of corticomedullary junction high-susceptibility region (CMJ-HSR) with aging: a clue in the pathogenesis of Alzheimer's disease?
    Tsutomu Nakada
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan
    J Neuroimaging 22:379-83. 2012
  3. pmc Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema
    Hironaka Igarashi
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Chuoh ku, Niigata, 951 8585, Japan
    Neurol Sci 32:113-6. 2011
  4. ncbi request reprint Clinical application of high and ultra high-field MRI
    Tsutomu Nakada
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Niigata 951 8585, Japan
    Brain Dev 29:325-35. 2007
  5. ncbi request reprint Three-dimensional anisotropy contrast periodically rotated overlapping parallel lines with enhanced reconstruction (3DAC PROPELLER) on a 3.0T system: a new modality for routine clinical neuroimaging
    Tsutomu Nakada
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Niigata 951 8585, Japan
    J Neuroimaging 16:206-11. 2006
  6. ncbi request reprint The passage to human MR microscopy: a progress report from Niigata on April 2005
    Tsutomu Nakada
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Asahimachi, Niigata 951 8585, Japan
    Magn Reson Med Sci 4:83-7. 2005
  7. ncbi request reprint Free convection schema defines the shape of the human brain: brain and self-organization
    Tsutomu Nakada
    Department of Integrated Neuroscience, Brain Research Institute, University of Niigata, 1 Asahimachi, Niigata, Japan
    Med Hypotheses 60:159-64. 2003
  8. ncbi request reprint Brain chip: a hypothesis
    Tsutomu Nakada
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Japan
    Magn Reson Med Sci 3:51-63. 2004
  9. ncbi request reprint Clinical experience on 3.0 T systems in Niigata, 1996 to 2002
    Tsutomu Nakada
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Niigata 951 8585, Japan
    Invest Radiol 38:377-84. 2003
  10. ncbi request reprint High-field, T2 reversed MRI of the hippocampus in transient global amnesia
    Tsutomu Nakada
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Niigata 951, Japan
    Neurology 64:1170-4. 2005

Collaborators

Detail Information

Publications75

  1. ncbi request reprint Brain developmental abnormalities in Prader-Willi syndrome detected by diffusion tensor imaging
    Kenichi Yamada
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Asahimachi 1 757, Niigata, 951 8585, Japan
    Pediatrics 118:e442-8. 2006
    ..The purpose of this work was to detect brain developmental abnormalities in Prader-Willi syndrome by using diffusion tensor imaging based on a high-field MRI system...
  2. doi request reprint Expansion of corticomedullary junction high-susceptibility region (CMJ-HSR) with aging: a clue in the pathogenesis of Alzheimer's disease?
    Tsutomu Nakada
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan
    J Neuroimaging 22:379-83. 2012
    ..0T system demonstrated the corticomedullary junction (CMJ) to be a high-susceptibility region (HSR) in young normal subjects, suggesting that functional alteration of cortical microcirculation could be assessed with this imaging method...
  3. pmc Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema
    Hironaka Igarashi
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Chuoh ku, Niigata, 951 8585, Japan
    Neurol Sci 32:113-6. 2011
    ..0 ± 7.6% in the treated group, compared to 30.0 ± 9.1% in the control group (p < 0.05). The study indicated the potential pharmacological use of AQP4 inhibition in reducing brain edema associated with focal ischemia...
  4. ncbi request reprint Clinical application of high and ultra high-field MRI
    Tsutomu Nakada
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Niigata 951 8585, Japan
    Brain Dev 29:325-35. 2007
    ..Magnetic resonance spectroscopy (MRS) and its pictorial display (spectroscopic imaging) is now finding more and more clinical applications across the age spectrum of patients...
  5. ncbi request reprint Three-dimensional anisotropy contrast periodically rotated overlapping parallel lines with enhanced reconstruction (3DAC PROPELLER) on a 3.0T system: a new modality for routine clinical neuroimaging
    Tsutomu Nakada
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Niigata 951 8585, Japan
    J Neuroimaging 16:206-11. 2006
    ....
  6. ncbi request reprint The passage to human MR microscopy: a progress report from Niigata on April 2005
    Tsutomu Nakada
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Asahimachi, Niigata 951 8585, Japan
    Magn Reson Med Sci 4:83-7. 2005
  7. ncbi request reprint Free convection schema defines the shape of the human brain: brain and self-organization
    Tsutomu Nakada
    Department of Integrated Neuroscience, Brain Research Institute, University of Niigata, 1 Asahimachi, Niigata, Japan
    Med Hypotheses 60:159-64. 2003
    ....
  8. ncbi request reprint Brain chip: a hypothesis
    Tsutomu Nakada
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Japan
    Magn Reson Med Sci 3:51-63. 2004
    ..The concept in this article has been translated into English by the author himself in response to an overwhelming number of requests from colleagues outside Japan...
  9. ncbi request reprint Clinical experience on 3.0 T systems in Niigata, 1996 to 2002
    Tsutomu Nakada
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Niigata 951 8585, Japan
    Invest Radiol 38:377-84. 2003
    ..High-field MRI is promising as an all-in-one system for both structural and functional assessments. This review summarizes the exciting features of clinical imaging based on our cumulative 6-year experience on various 3.0 T systems...
  10. ncbi request reprint High-field, T2 reversed MRI of the hippocampus in transient global amnesia
    Tsutomu Nakada
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Niigata 951, Japan
    Neurology 64:1170-4. 2005
    ..To investigate the fine structural integrity of the hippocampus in patients with transient global amnesia (TGA) using high-resolution T2 reversed (T2R) MRI...
  11. ncbi request reprint Coerced training of the nondominant hand resulting in cortical reorganization: a high-field functional magnetic resonance imaging study
    Tsutomu Nakada
    Center for Integrated Human Brain Science and Department of Neurosurgery, Brain Research Institute, University of Niigata, Japan
    J Neurosurg 101:310-3. 2004
    ..The authors investigated brain strategies associated with hand use in an attempt to clarify genetic and nongenetic factors influencing handedness by using high-field functional magnetic resonance imaging...
  12. ncbi request reprint Myths and truths in functional MRI: a basic guide for practitioners
    Tsutomu Nakada
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Niigata 951 8585, Japan
    Magn Reson Med Sci 1:89-107. 2002
    ..This article provides a distillation of the essential knowledge necessary for the non-MR physicist fMRI investigator...
  13. doi request reprint High-resolution imaging with high and ultra high-field magnetic resonance imaging systems
    Tsutomu Nakada
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Asahimachi, Niigata, Japan
    Neuroreport 19:7-13. 2008
    ..In MRI, the natural physico-chemical MR contrast properties of tissues can be taken advantage of to achieve this goal, thereby obviating the need for administering contrast material to individuals...
  14. ncbi request reprint Brain strategies for reading in the second language are determined by the first language
    T Nakada
    Department of Integrated Neuroscience Brain Research Institute, University of Niigata, 951 8585, Niigata, Japan
    Neurosci Res 40:351-8. 2001
    ....
  15. pmc Neuroscience of water molecules: a salute to professor Linus Carl Pauling
    Tsutomu Nakada
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Niigata, 951 8585, Japan
    Cytotechnology 59:145-52. 2009
    ....
  16. doi request reprint In vivo visualization of senile-plaque-like pathology in Alzheimer's disease patients by MR microscopy on a 7T system
    Tsutomu Nakada
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan
    J Neuroimaging 18:125-9. 2008
    ..Such an application provides not only the most accurate diagnostic tool for clinicians but also a solid basis for scientists for developing effective treatment and preventive strategies for AD...
  17. ncbi request reprint Human brain imaging in the upright position
    T Nakada
    Department of Integrated Neuroscience, Brain Research Institute, University of Niigata, Japan
    Neurology 57:1720-2. 2001
    ..Their vertical system was practical for routine clinical usage and might provide information regarding gravitational effects on regional perfusion and other aspects of brain physiology...
  18. ncbi request reprint Planum temporale: where spoken and written language meet
    T Nakada
    Department of Integrated Neuroscience, Brain Research Institute, University of Niigata, Japan
    Eur Neurol 46:121-5. 2001
    ..The destruction of this area can result in comprehension deficits in both spoken and written language, i.e. a classical case of Wernicke's aphasia...
  19. ncbi request reprint Clinical application of three-dimensional anisotropy contrast magnetic resonance axonography. Technical note
    T Nakada
    Department of Integrated Neuroscience, Brain Research Institute, University of Niigata, Asahimachi, Japan
    J Neurosurg 90:791-5. 1999
    ..As an imaging method uniquely capable of providing information regarding axonal connectivity, 3DAC MR axonography appears to have promising potential for routine clinical application...
  20. ncbi request reprint Independent component-cross correlation-sequential epoch (ICS) analysis of high field fMRI time series: direct visualization of dual representation of the primary motor cortex in human
    T Nakada
    Department of Integrated Neuroscience, Brain Research Institute, University of Niigata, Japan
    Neurosci Res 37:237-44. 2000
    ..ICS analysis appears to be a highly reliable and versatile technique for fMRI time series analysis...
  21. ncbi request reprint High-field (3.0 T) functional MRI sequential epoch analysis: an example for motion control analysis
    T Nakada
    Department of Integrated Neuroscience, Brain Research Institute, University of Niigata, Ashimachi, Japan
    Neurosci Res 32:355-62. 1998
    ....
  22. ncbi request reprint High-field magnetic resonance imaging in patients with moyamoya disease
    A Harada
    Department of Integrated Neuroscience, Brain Research Institute, University of Niigata, Japan
    J Neurosurg 94:233-7. 2001
    ..High-field T2-reversed MR imaging is useful in estimating cerebral circulation in patients with moyamoya disease...
  23. ncbi request reprint Asymmetry of parietal lobe activation during piano performance: a high field functional magnetic resonance imaging study
    K Itoh
    Department of Integrated Neuroscience, Brain Research Institute, University of Niigata, 1 Asahimachi, 951-8585, Niigata, Japan
    Neurosci Lett 309:41-4. 2001
    ..Furthermore, PPC activation exhibited significant asymmetry, with left hemisphere dominance. The results indicate that the left parietal lobe plays a significant role in the cortical processes of piano performance...
  24. doi request reprint Evaluation of post-procedure changes in aneurysmal lumen following detachable coil-placement using multi-planar reconstruction of high-field (3.0T) magnetic resonance angiography
    Y Yoneoka
    Department of Neurosurgery, Brain Research Institute, University of Niigata, Niigata, Japan
    Acta Neurochir (Wien) 150:351-8; discussion 358. 2008
    ..Development of higher magnetic field systems is steadily widening clinical usage of magnetic resonance imaging (MRI) primarily due to its significantly higher signal to noise ratio...
  25. ncbi request reprint Fast and precise independent component analysis for high field fMRI time series tailored using prior information on spatiotemporal structure
    Kiyotaka Suzuki
    Department of Integrated Neuroscience, Brain Research Institute, University of Niigata, Niigata, Japan
    Hum Brain Mapp 15:54-66. 2002
    ..A simple skewness-weighted contrast function was verified to extract sufficiently precise activation maps from the fMRI time series acquired using a 3.0 Tesla MRI system...
  26. ncbi request reprint Evaluation of efficacy of an automated single-voxel proton MRS algorithm on a 3T system
    Masaki Ohkubo
    Department of Radiological Technology, School of Health Sciences, Faculty of Medicine, University of Niigata, 2 746 Asahimachi dohri, Niigata shi, Niigata 951 8518, Japan
    Magn Reson Med Sci 1:121-4. 2002
    ..To evaluate the efficacy of a fully automatic, single-voxel, proton MR spectroscopy algorithm on a 3.0T MR system...
  27. ncbi request reprint Neural substrates for visual pattern recognition learning in Igo
    Kosuke Itoh
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 757 Asahimachi dori, Niigata, 951 8585, Japan
    Brain Res 1227:162-73. 2008
    ..These connections would provide the medium by which the fronto-parietal system modulates visual cortical activity to attain behaviorally relevant perceptions...
  28. ncbi request reprint Electrophysiological correlates of grapheme-phoneme conversion
    Koongliang Huang
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 757 Asahimachi dori, Niigata 951 8585, Japan
    Neurosci Lett 366:254-8. 2004
    ..Elicitation of SN2 in the vowel-matching task suggested that the vowel-matching task requires a wider range of neural activities exceeding the established conventional area of language processing...
  29. ncbi request reprint Diagnostic neuroimaging by magnetic resonance imaging: update
    Yukihiko Fujii
    Department of Neurosurgery, Brain Research Institute, University of Niigata, 757 Asahimachi dori 1, Niigata, Japan
    Neurol Med Chir (Tokyo) 50:833-8. 2010
    ....
  30. ncbi request reprint EZ-tracing: a new ready-to-use algorithm for magnetic resonance tractography
    Kenshi Terajima
    Department of Integrated Neuroscience, Brain Research Institute, University of Niigata, 1 Asahimachi, 951 8585, Niigata, Japan
    J Neurosci Methods 116:147-55. 2002
    ..The program is available in public at coe@bri.niigata-u.ac.jp...
  31. ncbi request reprint Identification of arylsulfonamides as Aquaporin 4 inhibitors
    Vincent J Huber
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 757 Asahi machi dori, Niigata 951 8585, Japan
    Bioorg Med Chem Lett 17:1270-3. 2007
    ..AZA was found to have an IC50 against AQP4 of 0.9 microM. Phloretin was inactive under the same conditions...
  32. doi request reprint Tract-by-tract morphometric and diffusivity analyses in vivo of spinocerebellar degeneration
    Kenshi Terajima
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan
    J Neuroimaging 19:220-6. 2009
    ..The purpose of this study was to confirm whether this technique can characterize the degenerative processes in the brainstem of patients with spinocerebellar degeneration (SCD)...
  33. ncbi request reprint Ear advantage and consonance of dichotic pitch intervals in absolute-pitch possessors
    Kosuke Itoh
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Japan
    Brain Cogn 53:464-71. 2003
    ..As the tones were dichotically presented, the results indicated that the central auditory system could distinguish between consonant and dissonant intervals without initial processing of pitch-pitch relations in the cochlea...
  34. ncbi request reprint Absolute eigenvalue diffusion tensor analysis for human brain maturation
    Yuji Suzuki
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata 951 8585, Japan
    NMR Biomed 16:257-60. 2003
    ....
  35. ncbi request reprint Serial assessments of delayed encephalopathy after carbon monoxide poisoning using magnetic resonance spectroscopy and diffusion tensor imaging on 3.0T system
    Kenshi Terajima
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan
    Eur Neurol 59:55-61. 2008
    ..The combination of (1)H-MRS and DTI on a 3.0T system is useful for monitoring the changes in brain damage and the clinical symptoms of patients with delayed encephalopathy after CO poisoning...
  36. ncbi request reprint Cell-oriented analysis in vivo using diffusion tensor imaging for normal-appearing brain tissue in multiple sclerosis
    Kenshi Terajima
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan
    Neuroimage 37:1278-85. 2007
    ..This cell-oriented analysis of NABT injury using DTI confirmed in vivo the histological observation that the juxtacortical region is the most vulnerable site in MS...
  37. doi request reprint Central auditory processing of noncontextual consonance in music: an evoked potential study
    Kosuke Itoh
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Asahimachi 1 757, Niigata 951 8585, Japan
    J Acoust Soc Am 128:3781-7. 2010
    ....
  38. ncbi request reprint Pre-operative histopathological evaluation of meningiomas by 3 0T T2R MRI
    Y Yoneoka
    Department of Neurosurgery, Brain Research Institute, University of Niigata, Niigata, Japan
    Acta Neurochir (Wien) 144:953-7; discussion 957. 2002
    ..To assess the potential of T2 reversed (T2R) magnetic resonance imaging (MRI) for the pre-operative histopathological assessment of meningiomas...
  39. ncbi request reprint Central tinnitus: a case report
    Y Yoneoka
    Department of Integrated Neuroscience, Brain Research Institute, University of Niigata, 1 Asahimachi, Niigata 951-8585, Japan
    Ear Nose Throat J 80:864-6. 2001
    ..This case provides substantial support for the concept that central tinnitus might indeed represent a pathologic activation of neural networks of nonspecific auditory perception...
  40. ncbi request reprint Feasibility study of single region lambda chart analysis for pyramidal tract physiology
    Yuji Suzuki
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Niigata 951 8585, Japan
    J Neurol 250:1185-9. 2003
    ..These findings are highly consistent with known pathophysiological indices and indicate the feasibility of the clinical utility of LCA for assessing pyramidal tract physiology...
  41. ncbi request reprint Diffusion tensor analysis in chronic schizophrenia. A preliminary study on a high-field (3.0T) system
    Hideaki Kitamura
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Niigata 951 8585, Japan
    Eur Arch Psychiatry Clin Neurosci 255:313-8. 2005
    ..LCA revealed that the decline in FA was due to a disproportionate increase in small eigenvalue components, and not due to a decline in principal eigenvalue components...
  42. ncbi request reprint Diffusion tensor analysis of peritumoral edema using lambda chart analysis indicative of the heterogeneity of the microstructure within edema
    Ken Ichi Morita
    Center for Integrated Human Brain Science, Department of Neurosurgery, Brain Research Institute, University of Niigata, Japan
    J Neurosurg 102:336-41. 2005
    ....
  43. ncbi request reprint Parietal white matter abnormalities in obsessive-compulsive disorder: a magnetic resonance spectroscopy study at 3-Tesla
    H Kitamura
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Acta Psychiatr Scand 114:101-8. 2006
    ..The white matter was also investigated because of recent research which suggests the altered connectivity of axons...
  44. ncbi request reprint Natural preference in luminosity for frame composition
    Naoharu Kobayashi
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Japan
    Neuroreport 18:1137-40. 2007
    ..The result provides clear-cut evidence that there is indeed a natural preference for a leftward bias in luminosity for frame composition...
  45. ncbi request reprint Increase in glutamate as a sensitive indicator of extracellular matrix integrity in peritumoral edema: a 3.0-tesla proton magnetic resonance spectroscopy study
    Teruo Kimura
    Center for Integrated Human Brain Science, Brain Research Institute, School of Health Sciences, Faculty of Medicine, University of Niigata, Japan
    J Neurosurg 106:609-13. 2007
    ..They tested this hypothesis using proton magnetic resonance (MR) spectroscopy on a 3.0-tesla system that is capable of quantifying Glu without need of editing...
  46. ncbi request reprint Cortical reorganization in patients with subcortical hemiparesis: neural mechanisms of functional recovery and prognostic implication
    Yukihiko Fujii
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Japan
    J Neurosurg 98:64-73. 2003
    ....
  47. ncbi request reprint Electrophysiological correlates of absolute pitch and relative pitch
    Kosuke Itoh
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Asahimachi Dori, Niigata, Japan
    Cereb Cortex 15:760-9. 2005
    ....
  48. ncbi request reprint Isotropic component trace analysis
    Hitoshi Matsuzawa
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Asahimachi, Niigata, Japan
    J Neuroimaging 15:233-9. 2005
    ..A ready-to-use program, EZ-LCA, for this powerful method is provided (available at http://coe.bri.niigata-u.ac.jp)...
  49. doi request reprint Preoperative depiction of cavernous sinus invasion by pituitary macroadenoma using three-dimensional anisotropy contrast periodically rotated overlapping parallel lines with enhanced reconstruction imaging on a 3-tesla system
    Yuichiro Yoneoka
    Department of Neurosurgery, Graduate School of Medical and Dental Sciences, University of Niigata, Japan
    J Neurosurg 108:37-41. 2008
    ....
  50. ncbi request reprint MT+/V5 activation without conscious motion perception: a high-field fMRI study
    Kosuke Itoh
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Asahimachi Dori, Niigata 951 8585, Japan
    Magn Reson Med Sci 4:69-74. 2005
    ....
  51. ncbi request reprint [MR analysis of brain function]
    T Nakada
    Department of Integrated Neuroscience Brain Research Institute, University of Niigata
    No To Hattatsu 31:212-6. 1999
    ..Because of its inherently non-invasive nature, MR technologies are especially important for the field of pediatric neurology and developmental neuroscience...
  52. ncbi request reprint Adult-onset leukoencephalopathy with vanishing white matter with a missense mutation in EIF2B5
    H Ohtake
    Department of Neurology, Brain Research Institute, Faculty of Medicine, Niigata University, Japan
    Neurology 62:1601-3. 2004
    ..MRI revealed diffuse white matter hyperintensity on T2-weighted images accompanied by hypointense areas on fluid-attenuated inversion recovery images. A homozygous missense mutation was identified in EIF2B5...
  53. ncbi request reprint The primary motor area for voluntary diaphragmatic motion identified by high field fMRI
    Takahiro Nakayama
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 757 Asahimachi, Niigata 951 8585, Japan
    J Neurol 251:730-5. 2004
    ..The results were highly consistent with the previously reported cortical area for the diaphragm determined by transcranial electrical/magnetic stimulation...
  54. ncbi request reprint Gender difference in passive listening to stories: high-field fMRI study using multiple subject analysis based on individual activation maps
    Koongliang Huang
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Niigata 951 8585, Japan
    Magn Reson Med Sci 1:165-8. 2002
  55. ncbi request reprint [Diffusion tensor analysis: principles and applications]
    Tsutomu Nakada
    Department of Integrated Neuroscience, Brain Research Institute, University of Niigata
    No To Shinkei 54:290-7. 2002
    ..Considering the array of possibilities, from neuronal tract tracing to neuronal density imaging, DTA is rapidly becoming an indispensable tool not only in neuroscience but also in clinical investigations of the brain...
  56. ncbi request reprint [High field MRI for diagnosis of brain tumors]
    Tsutomu Nakada
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata
    Nihon Rinsho 63:216-21. 2005
  57. doi request reprint Inhibition of aquaporin 4 by antiepileptic drugs
    Vincent J Huber
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Niigata 951 8585, Japan
    Bioorg Med Chem 17:418-24. 2009
    ..Seven of the assayed compounds were found to inhibit AQP4 function, while three did not. A linear correlation was indicated between the in silico docking energies and the in vitro AQP4 inhibitory activity at 20 microM...
  58. doi request reprint Activity-dependent glial swelling is impaired in aquaporin-4 knockout mice
    Hiroki Kitaura
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Japan Department of Neurophysiology, Brain Research Institute, University of Niigata, Japan
    Neurosci Res 64:208-12. 2009
    ..We conclude that AQP4 likely plays a significant role in neural activity-dependent glial swelling...
  59. doi request reprint Identification of aquaporin 4 inhibitors using in vitro and in silico methods
    Vincent J Huber
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Chuo Ku, 1 Asahi Machi Dori, Niigata 951 8585, Japan
    Bioorg Med Chem 17:411-7. 2009
    ..The AQP4 inhibitory IC(50) values of three compounds, 2-(nicotinamido)-1,3,4-thiadiazole, sumatriptan and rizatriptan, were subsequently found to be 3, 11, and 2 microM, respectively...
  60. ncbi request reprint [Functional MRI]
    Tsutomu Nakada
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 757 Asahimachi dori, Niigata 951 8585, Japan
    No To Shinkei 54:874-82. 2002
  61. ncbi request reprint Human primary motor cortex shows hemispheric specialization for speech
    Makoto Terumitsu
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan
    Neuroreport 17:1091-5. 2006
    ..The study demonstrated direct evidence that human primary motor cortex possesses clear-cut hemispheric specialization similar to that observed for the higher order cortices...
  62. ncbi request reprint Assessment of axonal degeneration along the human visual pathway using diffusion trace analysis
    Satoshi Ueki
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan
    Am J Ophthalmol 142:591-6. 2006
    ..The effectiveness of diffusion trace value analysis for non-invasive assessment of retinal ganglion cell (RGC) axonal degeneration at multiple anatomic levels along the human visual pathway under clinical setting was evaluated...
  63. ncbi request reprint Criteria for normalcy of cavities observed within the adult hippocampus: high-resolution magnetic resonance imaging study on a 3.0-T system
    Yuichiro Yoneoka
    Department of Integrated Neuroscience, Brain Research Institute, University of Niigata, 1 Asahimachi, Niigata 951 8585, Japan
    J Neuroimaging 12:231-5. 2002
    ..This study assessed the detailed characteristics of hippocampal cavities in normal subjects using a new high-resolution MRI technique in an attempt to define objective criteria of normalcy...
  64. ncbi request reprint Cortical processing of musical consonance: an evoked potential study
    Kosuke Itoh
    Center for Integrated Human Brain Research, Brain Research Institute, University of Niigata, Japan
    Neuroreport 14:2303-6. 2003
    ..The results indicate that neural processing of consonance depend not only on peripheral mechanisms in the inner ear but also on higher associative processing of pitch relationships in the cerebral cortex...
  65. ncbi request reprint All-phase MR angiography using independent component analysis of dynamic contrast enhanced MRI time series: phi-MRA
    Kiyotaka Suzuki
    Center for Integrated Brain Science, Brain Research Institute, University of Niigata, Japan
    Magn Reson Med Sci 2:23-7. 2003
    ..Accordingly, we applied ICA to dynamic MRI time series. The technique was found to be powerful, allowing for hitherto unobtainable assessment of regional cerebral hemodynamics in vivo...
  66. ncbi request reprint Effect of mild hypothermia on energy state recovery following transient forebrain ischemia in the gerbil
    Teruo Kimura
    Department of Neurosurgery, Ashikawa Medical College, Ashikawa, Japan
    Exp Brain Res 145:83-90. 2002
    ..7% and 5.2% in the NT group. The results of this experiment indicate that the protective effect of mild hypothermia is due to the high recovery rate of ATP and PCr and the prevention of a secondary decline in high phosphate energy...
  67. ncbi request reprint Evaluation of the response of metastatic brain tumors to stereotactic radiosurgery by proton magnetic resonance spectroscopy, 201TlCl single-photon emission computerized tomography, and gadolinium-enhanced magnetic resonance imaging
    Teruo Kimura
    Department of Neurosurgery and Radiology, Central Laboratory for Research and Education, Asahikawa Medical College, Asahikawa, Japan
    J Neurosurg 100:835-41. 2004
    ....
  68. ncbi request reprint [Forefront of neuro-imaging]
    Tsutomu Nakada
    Nihon Naika Gakkai Zasshi 94:1172-82. 2005
  69. ncbi request reprint Dorsolateral prefrontal lobe activation declines significantly with age--functional NIRS study
    Ingrid L Kwee
    Department of Neurology, University of California, Davis, VANCHCS, 150 Muir Road, Martinez, CA 94553, USA
    J Neurol 250:525-9. 2003
    ..The study indicates that blood flow response associated with DLPF activation declines as a function of age in cognitively normal individuals and that fNIRS can be used as a convenient, portable tool for assessing such activation...
  70. doi request reprint Identification of intestinal bicarbonate transporters involved in formation of carbonate precipitates to stimulate water absorption in marine teleost fish
    Yukihiro Kurita
    Department of Biological Sciences, Tokyo Institute of Technology, 4259 B 19 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
    Am J Physiol Regul Integr Comp Physiol 294:R1402-12. 2008
    ..We therefore propose a mechanism for HCO3(-) transport across the intestinal epithelial cells of marine fish that includes basolateral HCO3(-) uptake (NBCe1) and apical HCO3(-) secretion (Slc26a6A and Slc26a6B)...
  71. ncbi request reprint [Brain science of water molecules]
    Tsutomu Nakada
    Nihon Ronen Igakkai Zasshi 43:554-9. 2006
  72. ncbi request reprint Effect of orally administered Hochu-ekki-to, a Japanese herbal medicine, on contact hypersensitivity caused by repeated application of antigen
    Tsutomu Nakada
    Oriental Medicine Research Center of the Kitasato Institute, Tokyo, Japan
    Int Immunopharmacol 2:901-11. 2002
    ..These results suggest that oral administration of HET suppresses chronic contact hypersensitivity, and it can be assumed that the suppression of serum Ig E and Ig G1 and IL-4 in inflamed ear...
  73. ncbi request reprint Ammonia secretion from fish gill depends on a set of Rh glycoproteins
    Tsutomu Nakada
    Department of Biological Sciences, Tokyo Institute of Technology, Yokohama 226 8501, Japan
    FASEB J 21:1067-74. 2007
    ..These results suggest that pufferfish Rh glycoproteins are involved in ammonia excretion from the gill. These findings challenge the classic view that ammonia excretion in the fish gill occurs by passive diffusion...
  74. ncbi request reprint Localization of ammonia transporter Rhcg1 in mitochondrion-rich cells of yolk sac, gill, and kidney of zebrafish and its ionic strength-dependent expression
    Tsutomu Nakada
    Dept of Biological Sciences, Tokyo Institute of Technology, 4259 B19 Nagatsuta cho, Midori ku, Yokohama shi, Kanagawa Ken, 226 8501 Japan
    Am J Physiol Regul Integr Comp Physiol 293:R1743-53. 2007
    ..Remarkably, expression of Rhcg1 mRNA at the larval stage was changed by environmental ionic strength. These results suggest that roles of zebrafish Rhcg1 are not solely ammonia secretion to eliminate nitrogen from the gill...