Yasunobu Matsuda

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. pmc p27 Is a critical prognostic biomarker in non-alcoholic steatohepatitis-related hepatocellular carcinoma
    Yasunobu Matsuda
    Department of Medical Technology, Niigata University Graduate School of Health Sciences, 2 746 Asahimachi dori, Chuo Ku, Niigata 951 8518, Japan
    Int J Mol Sci 14:23499-515. 2013
  2. pmc Mycotoxins are conventional and novel risk biomarkers for hepatocellular carcinoma
    Yasunobu Matsuda
    Department of Medical Technology, Niigata University Graduate School of Health Sciences, Niigata 951 8518, Japan
    World J Gastroenterol 19:2587-90. 2013
  3. ncbi request reprint Clinical significance of cell cycle inhibitors in hepatocellular carcinoma
    Yasunobu Matsuda
    Department of Medical Technology, Niigata University Graduate School of Health Sciences, 2 746 Asahimachi dori, Niigata, 951 8518, Japan
    Med Mol Morphol 46:185-92. 2013
  4. pmc DNA damage sensor γ -H2AX is increased in preneoplastic lesions of hepatocellular carcinoma
    Yasunobu Matsuda
    Department of Medical Technology, Niigata University Graduate School of Health Sciences, 2 746 Asahimachi dori, Niigata 951 8518, Japan
    ScientificWorldJournal 2013:597095. 2013
  5. ncbi request reprint Overexpressed Id-1 is associated with a high risk of hepatocellular carcinoma development in patients with cirrhosis without transcriptional repression of p16
    Yasunobu Matsuda
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Cancer 104:1037-44. 2005
  6. pmc Molecular mechanism underlying the functional loss of cyclindependent kinase inhibitors p16 and p27 in hepatocellular carcinoma
    Yasunobu Matsuda
    Department of Medical Technology, Niigata University Graduate School of Health Sciences, Asahimachi dori 2 746, Niigata 9518518, Japan
    World J Gastroenterol 14:1734-40. 2008
  7. ncbi request reprint p16 and p27 are functionally correlated during the progress of hepatocarcinogenesis
    Yasunobu Matsuda
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi dori 1 757, Niigata, 951 8510, Japan
    Med Mol Morphol 39:169-75. 2006
  8. doi request reprint Impact of hepatitis B virus X protein on the DNA damage response during hepatocarcinogenesis
    Yasunobu Matsuda
    Department of Medical Technology, Niigata University Graduate School of Health Sciences, Niigata, 951 8518, Japan
    Med Mol Morphol 42:138-42. 2009
  9. doi request reprint Hepatocellular carcinoma and liver transplantation: clinical perspective on molecular targeted strategies
    Yasunobu Matsuda
    Department of Medical Technology, Niigata University Graduate School of Health Sciences, 2 746 Asahimachi dori, Niigata 951 8518, Japan
    Med Mol Morphol 44:117-24. 2011
  10. doi request reprint Sorafenib: complexities of Raf-dependent and Raf-independent signaling are now unveiled
    Yasunobu Matsuda
    Department of Medical Technology, Niigata University Graduate School of Health Sciences, Asahimachi Dori, Niigata, Japan
    Med Mol Morphol 44:183-9. 2011

Collaborators

Detail Information

Publications50

  1. pmc p27 Is a critical prognostic biomarker in non-alcoholic steatohepatitis-related hepatocellular carcinoma
    Yasunobu Matsuda
    Department of Medical Technology, Niigata University Graduate School of Health Sciences, 2 746 Asahimachi dori, Chuo Ku, Niigata 951 8518, Japan
    Int J Mol Sci 14:23499-515. 2013
    ..623, p = 0.016) by univariate analysis. Further studies with more patients are required to verify the usefulness of p27 as a biomarker for predicting tumor recurrence in NASH patients. ..
  2. pmc Mycotoxins are conventional and novel risk biomarkers for hepatocellular carcinoma
    Yasunobu Matsuda
    Department of Medical Technology, Niigata University Graduate School of Health Sciences, Niigata 951 8518, Japan
    World J Gastroenterol 19:2587-90. 2013
    ..The results suggested that serum OTA levels might be a good biomarker for HCC. In this article, we review recent studies of OTA, and discuss its possible significance as a biomarker of HCC...
  3. ncbi request reprint Clinical significance of cell cycle inhibitors in hepatocellular carcinoma
    Yasunobu Matsuda
    Department of Medical Technology, Niigata University Graduate School of Health Sciences, 2 746 Asahimachi dori, Niigata, 951 8518, Japan
    Med Mol Morphol 46:185-92. 2013
    ..Taking into consideration the complex interaction between p16 and p27, a comprehensive analysis including p16 and p27 would be useful for predicting the prognosis of HCC patients. ..
  4. pmc DNA damage sensor γ -H2AX is increased in preneoplastic lesions of hepatocellular carcinoma
    Yasunobu Matsuda
    Department of Medical Technology, Niigata University Graduate School of Health Sciences, 2 746 Asahimachi dori, Niigata 951 8518, Japan
    ScientificWorldJournal 2013:597095. 2013
    ..To evaluate the clinical usefulness of γ -H2AX in hepatocellular carcinoma (HCC), we measured the level of γ -H2AX in HCC, dysplastic nodule, and nontumorous liver diseases...
  5. ncbi request reprint Overexpressed Id-1 is associated with a high risk of hepatocellular carcinoma development in patients with cirrhosis without transcriptional repression of p16
    Yasunobu Matsuda
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Cancer 104:1037-44. 2005
    ..Recently, Id-1 was found to repress p16 in tumorous tissue specimens including hepatocellular carcinoma (HCC), but its relevance in precancerous liver tissues is unknown...
  6. pmc Molecular mechanism underlying the functional loss of cyclindependent kinase inhibitors p16 and p27 in hepatocellular carcinoma
    Yasunobu Matsuda
    Department of Medical Technology, Niigata University Graduate School of Health Sciences, Asahimachi dori 2 746, Niigata 9518518, Japan
    World J Gastroenterol 14:1734-40. 2008
    ..Since loss of p16 is closely related to functional inactivation of p27 in HCC, investigating both p16 and p27 may be useful for precise prognostic predictions in individuals with HCC...
  7. ncbi request reprint p16 and p27 are functionally correlated during the progress of hepatocarcinogenesis
    Yasunobu Matsuda
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi dori 1 757, Niigata, 951 8510, Japan
    Med Mol Morphol 39:169-75. 2006
    ..We suggest that assessment of the p16 status may be useful for a precise prognostic prediction for individuals with HCCs expressing high levels of p27...
  8. doi request reprint Impact of hepatitis B virus X protein on the DNA damage response during hepatocarcinogenesis
    Yasunobu Matsuda
    Department of Medical Technology, Niigata University Graduate School of Health Sciences, Niigata, 951 8518, Japan
    Med Mol Morphol 42:138-42. 2009
    ..In this review, we focus on the roles of HBX in DNA damage repair during HCC development, with a view to achieving a better understanding of the significance of HBX in the early steps of hepatocarcinogenesis...
  9. doi request reprint Hepatocellular carcinoma and liver transplantation: clinical perspective on molecular targeted strategies
    Yasunobu Matsuda
    Department of Medical Technology, Niigata University Graduate School of Health Sciences, 2 746 Asahimachi dori, Niigata 951 8518, Japan
    Med Mol Morphol 44:117-24. 2011
    ..For specifying cases with more effective and less harmful modalities, further investigation in clinical and basic research to identify unexpected effects are needed...
  10. doi request reprint Sorafenib: complexities of Raf-dependent and Raf-independent signaling are now unveiled
    Yasunobu Matsuda
    Department of Medical Technology, Niigata University Graduate School of Health Sciences, Asahimachi Dori, Niigata, Japan
    Med Mol Morphol 44:183-9. 2011
    ..To aid future work on sorafenib, we here review the current literature pertaining to sorafenib signaling and its clinical efficacy in both monotherapy and combination therapy...
  11. doi request reprint Blockade of ataxia telangiectasia mutated sensitizes hepatoma cell lines to sorafenib by interfering with Akt signaling
    Shun Fujimaki
    Department of Medical Technology, Niigata University Graduate School of Health Sciences, Niigata, Japan
    Cancer Lett 319:98-108. 2012
    ..Moreover, ATM inhibition effectively suppressed the sorafenib-induced cell migration. Taken together, manipulation of ATM activity might be a useful strategy for improving sorafenib treatment of HCC...
  12. doi request reprint Progression of hypermethylation of the p16(INK4A) gene from normal liver to nontumorous liver and hepatocellular carcinoma: an evaluation using quantitative PCR analysis
    So Kurita
    Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences of Niigata University, 1 754, Asahimachi Dori, Niigata City, 951 8122, Japan
    Dig Dis Sci 54:80-8. 2009
    ..There may be a greater proportion of cells which contain methylated p16 in nontumorous than in normal liver. However, the difference was so small that the functional relevance to hepatocarcinogenesis remains elusive...
  13. ncbi request reprint Multidrug resistance-associated protein 2 determines the efficacy of cisplatin in patients with hepatocellular carcinoma
    Pavel V Korita
    Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
    Oncol Rep 23:965-72. 2010
    ..Expression of MRP2 determines the efficacy of cisplatin-based chemotherapy in patients with HCC...
  14. ncbi request reprint Tumor suppressor carcinoembryonic antigen-related cell adhesion molecule 1 potentates the anchorage-independent growth of human hepatoma HepG2 cells
    Mariko Hokari
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi dori 1 757, Niigata 951 8510, Japan
    Life Sci 81:336-45. 2007
    ....
  15. doi request reprint Overexpression of osteopontin independently correlates with vascular invasion and poor prognosis in patients with hepatocellular carcinoma
    Pavel V Korita
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951 8510, Japan
    Hum Pathol 39:1777-83. 2008
    ..These results suggest that overexpression of osteopontin independently correlates with vascular invasion and thus predicts poor survival for patients with HCC, whereas aberrant expression of E-cadherin or beta-catenin does not...
  16. ncbi request reprint Reduced NKG2D ligand expression in hepatocellular carcinoma correlates with early recurrence
    Hiroteru Kamimura
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Hepatol 56:381-8. 2012
    ....
  17. ncbi request reprint Loss of liver-intestine cadherin in human intrahepatic cholangiocarcinoma promotes angiogenesis by up-regulating metal-responsive transcription factor-1 and placental growth factor
    Masaaki Takamura
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachi dori 1, Chuo Ku, Niigata 951 8510, Japan
    Int J Oncol 36:245-54. 2010
    ..Loss of LI-cadherin results in up-regulation of MTF-1 and PlGF, thereby regulating angiogenesis in ICC...
  18. doi request reprint Hepatitis B virus X induces cell proliferation in the hepatocarcinogenesis via up-regulation of cytoplasmic p21 expression
    Masahiko Yano
    Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences Niigata University, Niigata, Japan
    Liver Int 33:1218-29. 2013
    ..The effects of HBx on the expression and function of p21 also remain controversial...
  19. doi request reprint Ribonucleotide reductase M1 expression in intrahepatic cholangiocarcinoma
    Toshifumi Wakai
    Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hepatogastroenterology 58:1659-63. 2011
    ....
  20. doi request reprint P21-activated kinase-2 is a critical mediator of transforming growth factor-β-induced hepatoma cell migration
    Munehiro Sato
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Japan
    J Gastroenterol Hepatol 28:1047-55. 2013
    ..With the aim of investigating the diagnostic and treatment modalities for patients with hepatocellular carcinoma (HCC), the signaling pathway that may contribute to TGF-β-mediated cell invasion in hepatoma cells was evaluated...
  21. ncbi request reprint Loss of carcinoembryonic antigen-related cell adhesion molecule 1 expression predicts metachronous pulmonary metastasis and poor survival in patients with hepatoblastoma
    Mami Tsukada
    Division of Pediatric Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951 8510, Japan
    J Pediatr Surg 44:1522-8. 2009
    ..The aim of this study was to test the hypothesis that loss of CEACAM1 expression in hepatoblastoma cells may promote hematogeneous metastasis and function as an adverse prognostic factor...
  22. doi request reprint Alteration of p53-binding protein 1 expression as a risk factor for local recurrence in patients undergoing resection for extrahepatic cholangiocarcinoma
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
    Int J Oncol 38:1227-36. 2011
    ..0% at 5 years; P=0.020). In conclusion, after resection for extrahepatic cholangiocarcinoma, clinically evident local recurrence at ductal stumps is closely associated with 53BP1 inactivation and decreased apoptosis...
  23. ncbi request reprint MEK/ERK signaling is a critical mediator for integrin-induced cell scattering in highly metastatic hepatocellular carcinoma cells
    Nobuyuki Honma
    Division of Gastroenterology and Hepatology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Science, Niigata City, Japan
    Lab Invest 86:687-96. 2006
    ..In conclusion, cell scattering of the highly metastatic cell line KYN-2 is regulated through the integrin-MEK-ERK signaling cascade, suggesting that this molecular pathway may be critical in intrahepatic metastasis of human HCC...
  24. pmc Hepatitis B virus X stimulates redox signaling through activation of ataxia telangiectasia mutated kinase
    Yasunobu Matsuda
    Department of Medical Technology, Niigata University Graduate School of Health Sciences 2 746 Asahimachi dori, Chuo Ku, Niigata 951 8518, Japan
    Int J Clin Exp Pathol 7:2032-43. 2014
    ..Collectively, HBX stimulates the ATM-mediated PKC-δ/Nrf2 pathway, and maintains the enhanced activity of the redox system. Therefore, manipulating ATM kinase activity might be a useful strategy for treating HBX-induced carcinogenesis...
  25. ncbi request reprint Sustained response to interferon-alpha plus ribavirin therapy for chronic hepatitis C is closely associated with increased dynamism of intrahepatic natural killer and natural killer T cells
    Satoshi Yamagiwa
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hepatol Res 38:664-72. 2008
    ..041). Conclusion: These findings demonstrate that sustained response to IFN/RBV treatment for patients with CHC is closely associated with increased dynamism of NK and NKT cells in the liver...
  26. ncbi request reprint Overexpression of extracellular signal-regulated protein kinase and its correlation with proliferation in human hepatocellular carcinoma
    Yasunori Tsuboi
    Divison of Gastroenterology and Hepatology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
    Liver Int 24:432-6. 2004
    ....
  27. pmc Valproic acid overcomes transforming growth factor-β-mediated sorafenib resistance in hepatocellular carcinoma
    Yasunobu Matsuda
    Department of Medical Technology, Niigata University Graduate School of Health Sciences 2 746 Asahimachi dori, Chuo Ku, Niigata 951 8518, Japan
    Int J Clin Exp Pathol 7:1299-313. 2014
    ..Collectively, TGF-β/ERK/AKT signaling might play a critical role in sorafenib resistance in hepatoma cells, and combination treatment with VPA may be effective against this drug resistance. ..
  28. ncbi request reprint Loss of p16 contributes to p27 sequestration by cyclin D(1)-cyclin-dependent kinase 4 complexes and poor prognosis in hepatocellular carcinoma
    Yasunobu Matsuda
    Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medicine and Dental Science, Asahimachi dori 1 757, Niigata City 951 8510, Japan
    Clin Cancer Res 9:3389-96. 2003
    ..p27(Kip1) (p27) might act as an adverse prognostic marker for various types of cancers. However, its clinical usefulness remains uncertain, because it is sometimes overexpressed in aggressive types...
  29. ncbi request reprint Increase of CD4+ CD25+ regulatory T-cells in the liver of patients with hepatocellular carcinoma
    Xiu Hua Yang
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Hepatol 45:254-62. 2006
    ..Accumulating evidence indicates that the suppressive effects of CD4+ CD25+ regulatory T-cells are at least partially responsible for the failure of immune-mediated elimination of tumor cells...
  30. ncbi request reprint Clinicopathological analysis of CD133 and NCAM human hepatic stem/progenitor cells in damaged livers and hepatocellular carcinomas
    Atsunori Tsuchiya
    Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, Chuo Ku, Japan
    Hepatol Res 39:1080-90. 2009
    ..NCAM(+) HCC were detected, but their function remains unresolved. Expression of CD133, a potent stem cell marker, may be extremely rare in the common human HCC examined...
  31. ncbi request reprint Imbalance between CD56+bright and CD56+dim natural killer cell subsets in the liver of patients with recurrent hepatitis C after liver transplantation
    Satoshi Yamagiwa
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachidori, Chuo Ku, Niigata 951 8510, Japan
    Biomed Res 35:177-84. 2014
    ..Our results suggest that a significant imbalance between CD56+bright and CD56+dim NK cell subsets in the liver may contribute to the progression of recurrent CHC after LT...
  32. ncbi request reprint An inhibitor of c-Jun NH2-terminal kinase, SP600125, protects mice from D-galactosamine/lipopolysaccharide-induced hepatic failure by modulating BH3-only proteins
    Masaaki Takamura
    Department of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Life Sci 80:1335-44. 2007
    ..These results confirm the role of JNK as a critical apoptotic mediator in GalN/LPS-induced FHF. SP600125 has the potential to protect FHF by downregulating Bad and inhibiting Bid cleavage...
  33. ncbi request reprint Recurrence of hepatocellular carcinoma 102 months after successful eradication and removal of membranous obstruction of the inferior vena cava
    Masaaki Takamura
    Division of Gastroenterology and Hepatology, Department of Cellular Function, Course for Molecular and Cellular Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    J Gastroenterol 39:681-4. 2004
    ..This is the first reported case of HCC recurrence after successful treatment of MOVC...
  34. ncbi request reprint Early upsurge in anti-HBs titer possibly caused by the immunomodulative, not by the mutagenetic effect of interferon and ribavirin
    Kazuhide Yamazaki
    Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences of Niigata University, Niigata City, Japan
    Hepatol Res 37:477-81. 2007
    ..The immunomodulatory effect of ribavirin might have caused this unexpected early immune response to HBsAg that preceded seroconversion to anti-HBe...
  35. ncbi request reprint Altered expression of TLR homolog RP105 on monocytes hypersensitive to LPS in patients with primary biliary cirrhosis
    Yutaka Honda
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, 757, Asahimachi Dori 1, Niigata 951 8510, Japan
    J Hepatol 47:404-11. 2007
    ..Altered monocyte responses to ligands for TLRs have been reported in patients with primary biliary cirrhosis (PBC), yet the precise mechanism remains unknown...
  36. pmc Long-term outcomes of hepatectomy vs percutaneous ablation for treatment of hepatocellular carcinoma < or =4 cm
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    World J Gastroenterol 12:546-52. 2006
    ..To determine which treatment modality--hepatectomy or percutaneous ablation--is more beneficial for patients with small hepatocellular carcinoma (HCC) (< or =4 cm) in terms of long-term outcomes...
  37. doi request reprint Involvement of liver-intestine cadherin in cancer progression
    Masaaki Takamura
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata, Japan
    Med Mol Morphol 46:1-7. 2013
    ..Here, we review recent information about LI-cadherin and its implications for cancer progression...
  38. pmc Risk of subsequent biliary malignancy in patients undergoing cyst excision for congenital choledochal cysts
    Taku Ohashi
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Gastroenterol Hepatol 28:243-7. 2013
    ..The aim of this study was to elucidate the risk of subsequent biliary malignancy in patients undergoing cyst excision for congenital choledochal cysts...
  39. ncbi request reprint Complete disappearance of pulmonary metastases in a case of hepatocellular carcinoma treated with docetaxel-based systemic chemotherapy
    Toru Ishikawa
    Department of Internal Medicine III, Niigata University School of Medicine, Niigata, Japan
    J Gastroenterol Hepatol 19:1423-6. 2004
    ..No recurrence of pulmonary metastasis was seen for 10 months. This combination therapy was well-tolerated for lung cancer and could represent an effective treatment for pulmonary metastases from HCC...
  40. ncbi request reprint Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma
    Masaaki Takamura
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Japan
    Cancer Lett 212:253-9. 2004
    ..033), lymph node metastasis (P = 0.015), and an advanced pTNM stage (P = 0.033). These results suggest that analysis of LI-cadherin expression may help to indicate the biological aggressiveness of this malignancy...
  41. doi request reprint Effects of rapamycin on granulation formation in response to centrally doubled coiled stents as a tracheal substitute
    Masayuki Kubota
    Department of Pediatric Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan Electronic address
    J Pediatr Surg 48:2416-24. 2013
    ..We examined the involvement of the mammalian target of rapamycin (mTOR) signaling pathway in granulation formation and examined the effects of rapamycin...
  42. doi request reprint Rectal administration of tranilast ameliorated acute colitis in mice through increased expression of heme oxygenase-1
    Xiaomei Sun
    Department of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Pathol Int 60:93-101. 2010
    ..Tranilast might exert these effects partly through enhanced HO-1 expression in the colon, suggesting a potential adjunctive therapy for IBD...
  43. pmc Successful treatment with lamivudine may correlate with reduction of serum ferritin levels in the patients with chronic hepatitis and liver cirrhosis type B
    Shogo Ohkoshi
    Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences of Niigata University, 1 754, Asahimachi Dori, Niigata City, 951 8122, Japan
    Hepatol Int 2:382-7. 2008
    ..To study the changes in serum ferritin levels in lamivudine (LAM)-treated patients with chronic hepatitis and liver cirrhosis type B and determine whether successful treatment with LAM results in a reduction of serum ferritin levels...
  44. ncbi request reprint Temporal treatment with interferon-beta prevents hepatocellular carcinoma in hepatitis B virus X gene transgenic mice
    Kazuhide Yamazaki
    Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences of Niigata University, 1 754, Asahimachi Dori, Niigata city 951 8122, Japan
    J Hepatol 48:255-65. 2008
    ..We sought to determine whether the temporal administration of IFN-beta prevents hepatocarcinogenesis in a mouse model where HCC develops without necroinflammation...
  45. doi request reprint Characterization of elevated alanine aminotransferase levels during pegylated-interferon α-2b plus ribavirin treatment for chronic hepatitis C
    Yo Hei Aoki
    Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences Niigata University Niigata Municipal Hospital Tachikawa General Hospital Nagaoka Red Cross Hospital Sai sei kai Second Hospital Takeda General Hospital Watanabe Clinic, Niigata, Japan
    Hepatol Res 41:118-25. 2011
    ..Conclusion:  Abnormal ALT values during peg-IFN plus ribavirin treatment are observed relatively frequently, even in patients without detectable HCV RNA. Direct or indirect involvement of drugs is considered as one possible cause...
  46. ncbi request reprint [A case with chronic hepatitis C who developed liver cirrhosis due to liver dysfunction caused by pegylated interferon plus ribavirin treatment despite negativity of serum HCV RNA, during therapy]
    Shogo Ohkoshi
    Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Japan
    Nihon Shokakibyo Gakkai Zasshi 108:267-74. 2011
    ..Post-treatment liver biopsy showed liver cirrhosis, probably due to the interferon treatment itself. This unusual therapeutic outcome should be considered if the levels of hepatic dysfunction during interferon treatment are severe...
  47. pmc Prognostic significance of NQO1 expression in intrahepatic cholangiocarcinoma
    Toshifumi Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences Niigata, Japan
    Int J Clin Exp Pathol 4:363-70. 2011
    ..001) and loss of NQO1 expression (p<0.001) had an independent adverse effect on survival. Loss of NQO1 expression reflects dedifferentiation and thus indicates a poor prognosis for patients undergoing resection for ICC...
  48. ncbi request reprint Failure to achieve 2-log10 viral decrease in first four weeks of peg-IFNalpha-2b plus ribavirin therapy for chronic hepatitis C with genotype 1b and high viral titer is useful in predicting non-response: evaluation of response-guided therapy
    Shogo Ohkoshi
    Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Japan
    Hepatogastroenterology 58:965-70. 2011
    ..To clarify clinical parameters predicting sustained viral response (SVR) during 48 weeks pegylated-interferon (peg-IFN)alpha-2b plus ribavirin therapy for Japanese patients with chronic hepatitis C [CH(C)] genotype 1b and high viral titers...
  49. pmc Plasma cells and the chronic nonsuppurative destructive cholangitis of primary biliary cirrhosis
    Toru Takahashi
    Division of Gastroenterology and Hepatology, Nagaoka Red Cross Hospital, Nagaoka, Niigata, Japan
    Hepatology 55:846-55. 2012
    ..Patients with PBC who manifest this unique coronal arrangement were those with significantly higher titers of anti-mitochondrial antibodies...
  50. ncbi request reprint Long-term extensive expansion of mouse hepatic stem/progenitor cells in a novel serum-free culture system
    Atsunori Tsuchiya
    Department of Pediatrics, Graduate School of Medicine, Kyoto University, Japan
    Gastroenterology 128:2089-104. 2005
    ..The liver has high regenerative potential. We attempted to establish a novel culture system for extensive expansion of fetal mouse hepatic stem/progenitor cells and to characterize cultured cells...