Hiroki Maruyama

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. pmc Screening of male dialysis patients for fabry disease by plasma globotriaosylsphingosine
    Hiroki Maruyama
    Department of Clinical Nephroscience, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Clin J Am Soc Nephrol 8:629-36. 2013
  2. pmc Simultaneous gene transfer of bone morphogenetic protein (BMP) -2 and BMP-7 by in vivo electroporation induces rapid bone formation and BMP-4 expression
    Mariko Kawai
    Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700 8525, Japan
    BMC Musculoskelet Disord 7:62. 2006
  3. ncbi request reprint Rat kidney-targeted naked plasmid DNA transfer by retrograde injection into the renal vein
    Hiroki Maruyama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 754 Asahimachi dori, Niigata 951 8120, Japan
    Mol Biotechnol 27:23-31. 2004
  4. ncbi request reprint Post-secretion neutralization of transgene-derived effect: soluble erythropoietin receptor/IgG1Fc expressed in liver neutralizes erythropoietin produced in muscle
    H Maruyama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachidori, Niigata 951 8120, Japan
    J Gene Med 6:228-37. 2004
  5. ncbi request reprint Rat liver-targeted naked plasmid DNA transfer by tail vein injection
    Hiroki Maruyama
    Hiroki Maruyama, MD, Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 754 Asahimachi dori, Niigata 951 8120, Japan
    Mol Biotechnol 26:165-72. 2004
  6. ncbi request reprint Requiring higher doses of erythropoietin suggests pregnancy in hemodialysis patients
    H Maruyama
    Department of Medicine II, Niigata University School of Medicine, Niigata, Japan
    Nephron 79:413-9. 1998
  7. ncbi request reprint High-level expression of naked DNA delivered to rat liver via tail vein injection
    H Maruyama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8120, Japan
    J Gene Med 4:333-41. 2002
  8. ncbi request reprint Sustained transgene expression in rat kidney with naked plasmid DNA and PCR-amplified DNA fragments
    Hiroki Maruyama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8120
    J Biochem 137:373-80. 2005
  9. ncbi request reprint Magnetic resonance imaging of pseudotumors of the craniovertebral junction in long-term hemodialysis patients
    H Maruyama
    Department of Medicine II, Niigata University School of Medicine, Niigata, Japan
    Am J Nephrol 19:541-5. 1999
  10. ncbi request reprint Kidney-targeted naked DNA transfer by retrograde renal vein injection in rats
    Hiroki Maruyama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8120, Japan
    Hum Gene Ther 13:455-68. 2002

Collaborators

Detail Information

Publications43

  1. pmc Screening of male dialysis patients for fabry disease by plasma globotriaosylsphingosine
    Hiroki Maruyama
    Department of Clinical Nephroscience, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Clin J Am Soc Nephrol 8:629-36. 2013
    ..Elevated plasma globotriaosylsphingosine is reported to be a hallmark of classic Fabry disease. The purpose of this study was to examine the usefulness of globotriaosylsphingosine as a secondary screening target for Fabry disease...
  2. pmc Simultaneous gene transfer of bone morphogenetic protein (BMP) -2 and BMP-7 by in vivo electroporation induces rapid bone formation and BMP-4 expression
    Mariko Kawai
    Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700 8525, Japan
    BMC Musculoskelet Disord 7:62. 2006
    ..To promote enhanced osteoinduction using this method, we simultaneously transferred cDNAs for BMP-2 and BMP-7, as inserts in the non-viral vector pCAGGS...
  3. ncbi request reprint Rat kidney-targeted naked plasmid DNA transfer by retrograde injection into the renal vein
    Hiroki Maruyama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 754 Asahimachi dori, Niigata 951 8120, Japan
    Mol Biotechnol 27:23-31. 2004
    ..In this article, protocols for naked plasmid DNA transfer into rat kidney using this hydrodynamics-based transfection method and the immunoelectron microscopic technique to determine the lacZ gene transfer site are described in detail...
  4. ncbi request reprint Post-secretion neutralization of transgene-derived effect: soluble erythropoietin receptor/IgG1Fc expressed in liver neutralizes erythropoietin produced in muscle
    H Maruyama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachidori, Niigata 951 8120, Japan
    J Gene Med 6:228-37. 2004
    ..Neutralization following secretion is another important backup system to prevent super-therapeutic levels of a protein from being expressed by gene transfer...
  5. ncbi request reprint Rat liver-targeted naked plasmid DNA transfer by tail vein injection
    Hiroki Maruyama
    Hiroki Maruyama, MD, Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 754 Asahimachi dori, Niigata 951 8120, Japan
    Mol Biotechnol 26:165-72. 2004
    ..We also injected a rat erythropoietin (Epo) expression plasmid, pCAGGS-Epo (800 microg). Maximal Epo gene expression was achieved when a 25-mL injection volume (approx 100 mL/kg body wt) was transferred within 15 s...
  6. ncbi request reprint Requiring higher doses of erythropoietin suggests pregnancy in hemodialysis patients
    H Maruyama
    Department of Medicine II, Niigata University School of Medicine, Niigata, Japan
    Nephron 79:413-9. 1998
    ..The outcome is influenced by pregnancy-related anemia. We investigated the characteristics of pregnancy-related anemia and whether it is a useful diagnostic clue to pregnancy in HD patients...
  7. ncbi request reprint High-level expression of naked DNA delivered to rat liver via tail vein injection
    H Maruyama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8120, Japan
    J Gene Med 4:333-41. 2002
    ..Rats are more tolerant of the frequent phlebotomies required for monitoring blood parameters than mice, and thus are better for some biomedical research...
  8. ncbi request reprint Sustained transgene expression in rat kidney with naked plasmid DNA and PCR-amplified DNA fragments
    Hiroki Maruyama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8120
    J Biochem 137:373-80. 2005
    ....
  9. ncbi request reprint Magnetic resonance imaging of pseudotumors of the craniovertebral junction in long-term hemodialysis patients
    H Maruyama
    Department of Medicine II, Niigata University School of Medicine, Niigata, Japan
    Am J Nephrol 19:541-5. 1999
    ....
  10. ncbi request reprint Kidney-targeted naked DNA transfer by retrograde renal vein injection in rats
    Hiroki Maruyama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8120, Japan
    Hum Gene Ther 13:455-68. 2002
    ..This novel technique is simple and safe, allowing high-level and long-term stable gene expression specific to the fibroblasts near the PTC, and should have therapeutic value for future applications in humans...
  11. ncbi request reprint Continuous erythropoietin delivery by muscle-targeted gene transfer using in vivo electroporation
    H Maruyama
    Department of Medicine II, Niigata University School of Medicine, Japan
    Hum Gene Ther 11:429-37. 2000
    ..These results demonstrate that muscle-targeted pCAGGS-Epo transfer by in vivo electroporation is a useful procedure for the continuous delivery of Epo...
  12. ncbi request reprint Hydrodynamic-based delivery of an interleukin-22-Ig fusion gene ameliorates experimental autoimmune myocarditis in rats
    He Chang
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Immunol 177:3635-43. 2006
    ....
  13. ncbi request reprint Pretreatment plasma intact parathyroid hormone and serum calcium levels, but not serum phosphate levels, predict the response to maxacalcitol therapy in dialysis patients with secondary hyperparathyroidism
    Yuko Oyama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 751 Asahimachi dori, Niigata 951 8510, Japan
    Clin Exp Nephrol 9:142-7. 2005
    ..More evidence is needed to avoid the aimless continuation of active vitamin D therapy...
  14. ncbi request reprint Effects of erythropoietin-gene electrotransfer in rats with adenine-induced renal failure
    Ken Ataka
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Am J Nephrol 23:315-23. 2003
    ..Here, we apply this method to a rat model with severe anemia associated with chronic renal failure; these rats have hematocrit levels in the 30-35% range, similar to those in humans with end-stage renal disease...
  15. ncbi request reprint Alteration of IL-17 related protein expressions in experimental autoimmune myocarditis and inhibition of IL-17 by IL-10-Ig fusion gene transfer
    He Chang
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Circ J 72:813-9. 2008
    ..Experimental autoimmune myocarditis (EAM) is a T cell-mediated autoimmune disease; however, the pathogenic role of IL-17 in the development of rat EAM remains largely unknown...
  16. ncbi request reprint The effect of hydrodynamics-based delivery of an IL-13-Ig fusion gene for experimental autoimmune myocarditis in rats and its possible mechanism
    Raafat Elnaggar
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Eur J Immunol 35:1995-2005. 2005
    ..We conclude that IL-13-Ig ameliorates EAM and suppose that its effectiveness may be due to the influence on these immunologic molecules in CD11b(+) and NCNI cells...
  17. doi request reprint Naked plasmid DNA-based alpha-galactosidase A gene transfer partially reduces systemic accumulation of globotriaosylceramide in Fabry mice
    Gen Nakamura
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, 951 8510, Japan
    Mol Biotechnol 38:109-19. 2008
    ..Our results demonstrated that, although further studies are needed to improve the outcome, this method has promise as a potential treatment option for Fabry disease...
  18. doi request reprint Electroporation-mediated transfer of plasmid DNA encoding IL-10 attenuates orthotopic tracheal allograft stenosis in rats
    Masanori Tsuchida
    Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medicine and Dental Science, Niigata, Japan
    Transpl Immunol 19:173-7. 2008
    ..Using this technique, we examined the effect of viral IL-10 gene transfer on the prevention of tracheal allograft stenosis in an animal model...
  19. doi request reprint Alterations in serum phosphate levels predict the long-term response to intravenous calcitriol therapy in dialysis patients with secondary hyperparathyroidism
    Kiyoko Hosaka
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 751 Asahimachi dori, Niigata, Niigata 951 8510, Japan
    J Bone Miner Metab 26:185-90. 2008
    ..Changes in treatment are recommended if patients show unsatisfactory parathyroid suppression with a hyperphosphatemic tendency...
  20. ncbi request reprint Effects of viral interleukin 10 introduced by in vivo electroporation on arthrogen-induced arthritis in mice
    Takeshi Kuroda
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi Dori, Niigata City, Japan
    J Rheumatol 33:455-62. 2006
    ..We examined the applicability of vIL-10 gene transfer to the treatment of mice with arthrogen-collagen-induced arthritis (CIA), which is induced by anti-type II collagen antibodies...
  21. ncbi request reprint Circulating osteoprotegerin affects bone metabolism in dialysis patients with mild secondary hyperparathyroidism
    Junichiro James Kazama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Ther Apher Dial 10:262-6. 2006
    ..Circulating OPG might have a suppressive effect on osteoclastic bone resorption in dialysis patients...
  22. ncbi request reprint Attenuation of mouse acute colitis by naked hepatocyte growth factor gene transfer into the liver
    Takayasu Hanawa
    Department of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City, Niigata 951 8510, Japan
    J Gene Med 8:623-35. 2006
    ..Hepatocyte growth factor (HGF) has multiple biological effects on a wide variety of cells. It modulates intestinal epithelial proliferation and migration, and critically regulates intestinal wound healing...
  23. ncbi request reprint Maxacalcitol is a possible less phosphatemic vitamin D analog
    Junichiro J Kazama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Ther Apher Dial 9:352-4. 2005
    ..05). Thus, maxacalcitol is a possible less phosphatemic active vitamin D agent, if not non-phosphatemic agent, which might reduce the risk of extraskeletal calcification...
  24. ncbi request reprint Abeta-2M-amyloidosis and related bone diseases
    Junichiro James Kazama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 754 Asahimachi dori, Niigata, 951 8510, Japan
    J Bone Miner Metab 24:182-4. 2006
    ..The precise cell biological mechanism of this inflammatory change is unknown. Further studies are needed to establish specific treatments against this as yet unsolved problem with long-term dialysis therapy...
  25. ncbi request reprint Pretreatment serum FGF-23 levels predict the efficacy of calcitriol therapy in dialysis patients
    Junichiro J Kazama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Kidney Int 67:1120-5. 2005
    ..Fibroblast growth factor-23 (FGF-23) is a newly found circulating phosphaturic factor. Its circulating level is elevated in uremia...
  26. ncbi request reprint Direct comparison between two 1-84PTH assays in dialysis patients
    Junichiro J Kazama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Nephron Clin Pract 99:c8-12. 2005
    ..Today, two kinds of 1-84PTH assays are available in clinical practice. Few studies have directly compared the results of these assays in the same plasma...
  27. ncbi request reprint Circulating 1-84 PTH and large C-terminal PTH fragment levels in uremia
    Junichiro James Kazama
    Division of Clinical Nephrology and Intensive Care Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Clin Exp Nephrol 7:144-9. 2003
    ..The so-called "intact parathyroid hormone (iPTH)" assay detects large C-terminal PTH fragments that are lacking several N-terminal amino acid residues in addition to 1-84 PTH molecules...
  28. ncbi request reprint Intact PTH assay overestimates true 1-84 PTH levels after maxacalcitol therapy in dialysis patients with secondary hyperparathyroidism
    Junichiro J Kazama
    FJSIM, Division of Intensive Care Medicine, Niigata University Medical Hospital, 1 754 Asahimachi dori, Niigata, Niigata 951 8510, Japan
    Nephrol Dial Transplant 19:892-7. 2004
    ..Previous studies have shown that the results of these two PTH assays in dialysis patients are closely correlated...
  29. ncbi request reprint Hydrodynamics-based delivery of plasmid DNA encoding CTLA4-Ig prolonged cardiac allograft survival in rats
    Masaru Takekubo
    Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Gene Med 10:290-7. 2008
    ..Using this technique, we examined the effect of rat CTLA4-Ig gene transfer on prevention of cardiac allograft rejection in this animal model...
  30. ncbi request reprint [Diagnosis and therapy for beta2-microglobulin amyloidosis in the K/DOQI guideline]
    Noboru Higuchi
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences
    Clin Calcium 14:744-9. 2004
    ..Screening for beta2-microglobulin amyloidosis, including measurement of serum levels of beta2-microglobulin, is not recommended (OPINION)...
  31. ncbi request reprint Longitudinal change in renal function in patients with idiopathic dilated cardiomyopathy without renal insufficiency at initial diagnosis
    Komei Tanaka
    Division of Cardiology, Department of Clinical Nephroscience, Niigata University Graduate School of Medical and Dental Sciences, Japan
    Circ J 71:1927-31. 2007
    ..Impaired renal function is associated with poor outcomes among patients with chronic heart failure (CHF). However, the long-term changes in renal function in CHF patients without renal insufficiency at initial diagnosis remain unclear...
  32. ncbi request reprint Hypersensitivity to paraoxybenzoic Acid esters (parabens) in a dialysis patient
    Kiyoko Sato
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Nephron 92:728-9. 2002
    ..We concluded that the allergen in this patient was not heparin but parabens. Hypereosinophilia of unknown origin often occurs in dialysis patients. Such patients may be hypersensitive to parabens...
  33. ncbi request reprint Rapid detection of causative pathogen of peritonitis using in-situ hybridization in a patient with continuous ambulatory peritoneal dialysis
    Kyuma Ota
    Division of Clinical Nephrology, Respiratory Medicine and Infection Control and Prevention, Niigata University Graduate School of Medical and Dental Sciences, Niigata University Medical School, Niigata 951 8510, Japan
    J Infect Chemother 13:273-5. 2007
    ..The Hybrizep method (which is available on the Japanese National Health system only for the diagnosis of septicemia) was a useful diagnostic approach for a patient on peritoneal dialysis who had peritonitis...
  34. ncbi request reprint Epidermis-targeted gene transfer using in vivo electroporation
    Hiroki Maruyama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Methods Mol Biol 289:431-6. 2005
    ..These results demonstrate that plasmid deoxyribonucleic acid transfer by in vivo electro poration at low voltage is a useful procedure for short-term skin-targeted gene transfer...
  35. ncbi request reprint A novel method to assay proteins in blood plasma after intravenous injection of plasmid DNA
    Haruo Hanawa
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Science, Niigata 951 8510, Japan
    Tohoku J Exp Med 202:155-61. 2004
    ..These results demonstrate a useful and convenient method to assay gene therapy products circulating in blood using a glucagon 19-29 tagging vector...
  36. doi request reprint Novel mutations of the GLA gene in Japanese patients with Fabry disease and their functional characterization by active site specific chaperone
    Masaaki Shimotori
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hum Mutat 29:331. 2008
    ..Although ASSC therapy is useful only for misfolding mutants and therefore not applicable to all cases, it may be useful for treating many Japanese patients with Fabry disease...
  37. ncbi request reprint Combined radioguided parathyroidectomy and intravenous vitamin D therapy for the treatment of uraemic hyperparathyroidism
    Yuko Oyama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata University Medical Hospital, Japan
    Nephrol Dial Transplant 18:iii76-8. 2003
    ..Further study needs to elucidate whether this treatment strategy can improve the long-term prognosis of patients with secondary hyperparathyroidism..
  38. ncbi request reprint Serum cystatin C reliably detects renal dysfunction in patients with various renal diseases
    Junichiro James Kazama
    Department of Medicine II, Niigata University Medical School, Niigata, Japan
    Nephron 91:13-20. 2002
    ..In conclusion, serum cystatin C measurement is an excellent diagnostic test for detecting patients with subclinical renal dysfunction...
  39. ncbi request reprint Arresting dialysis-related amyloidosis: a prospective multicenter controlled trial of direct hemoperfusion with a beta2-microglobulin adsorption column
    Fumitake Gejyo
    Division of Clinical Nephrology and Rheumatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Artif Organs 28:371-80. 2004
    ..Thus, the Lixelle column is useful in preventing the progression of dialysis-related amyloidosis and in ameliorating or arresting the progression of the symptoms of this disorder...
  40. ncbi request reprint [Acquired coagulation abnormality due to factor V inhibitor]
    Noriaki Iino
    Division of Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata
    Nihon Naika Gakkai Zasshi 91:3295-7. 2002
  41. ncbi request reprint Long-term production of erythropoietin after electroporation-mediated transfer of plasmid DNA into the muscles of normal and uremic rats
    H Maruyama
    Department of Medicine (II, Niigata University School of Medicine, Niigata, Japan
    Gene Ther 8:461-8. 2001
    ..These results demonstrate that muscle-targeted pCAGGS-Epo transfer by in vivo electroporation is a useful procedure for the long-term continuous delivery of Epo in both normal and uremic rats...
  42. ncbi request reprint Effect of hydrodynamics-based gene delivery of plasmid DNA encoding interleukin-1 receptor antagonist-Ig for treatment of rat autoimmune myocarditis: possible mechanism for lymphocytes and noncardiac cells
    Hui Liu
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Japan
    Circulation 111:1593-600. 2005
    ..The purpose of this study was to evaluate the effect and possible mechanism of hydrodynamics-based delivery of the IL-1 receptor antagonist (IL-1RA)-immunoglobulin (Ig) gene for treatment of rat experimental autoimmune myocarditis (EAM)...
  43. ncbi request reprint The sequential organ failure assessment score as a useful predictor for estimating the prognosis of systemic inflammatory response syndrome patients being treated with extracorporeal blood purification
    Hiroshi Kikuchi
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Ther Apher Dial 7:456-60. 2003
    ..The changes in the SOFA score correlated well with the outcomes of the SIRS patients. The maximum SOFA score and the DeltaSOFA score are therefore likely to be useful prognostic markers...