Nishizawa R, Nagata M, Noman A, Kitamura N, Fujita H, Hoshina H, et al. The 2G allele of promoter region of matrix metalloproteinase-1 as an essential pre-condition for the early onset of oral squamous cell carcinoma. BMC Cancer. 2007;7:187 pubmed
..However this report suggests a crucial impact of the MMP-1 2G allele in the early onset OSCC. ..
Nezu A, Kubota T, Maruyama S, Nagata M, Nohno K, Morozumi T, et al. Expression of neprilysin in periodontitis-affected gingival tissues. Arch Oral Biol. 2017;79:35-41 pubmed publisher
..However, NEP has several effects including degradation of vasoactive substances; therefore, further sresearch is needed. ..