Ryo Kominami

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. ncbi request reprint Radiation carcinogenesis in mouse thymic lymphomas
    Ryo Kominami
    Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, and Center for Transdisciplinary Research, Niigata University, 1 757 Asahimachi, Niigata 951 8122
    Cancer Sci 97:575-81. 2006
  2. pmc Role of the transcription factor Bcl11b in development and lymphomagenesis
    Ryo Kominami
    Department of Molecular Genetics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 88:72-87. 2012
  3. ncbi request reprint Haploinsufficiency of Bcl11b for suppression of lymphomagenesis and thymocyte development
    Kenya Kamimura
    Department of Molecular Genetics, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1 757, Niigata 951 8510, Japan
    Biochem Biophys Res Commun 355:538-42. 2007
  4. doi request reprint Effect of Bcl11b genotypes and gamma-radiation on the development of mouse thymic lymphomas
    Yoshihiro Yoshikai
    Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1 757, Chuo Ku, Niigata 951 8510, Japan
    Biochem Biophys Res Commun 373:282-5. 2008
  5. doi request reprint Bcl11b heterozygosity promotes clonal expansion and differentiation arrest of thymocytes in gamma-irradiated mice
    Rieka Go
    Department of Molecular Genetics, Niigata University, Niigata, Japan
    Cancer Sci 101:1347-53. 2010
  6. ncbi request reprint Predisposition to mouse thymic lymphomas in response to ionizing radiation depends on variant alleles encoding metal-responsive transcription factor-1 (Mtf-1)
    Yasushi Tamura
    Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1 757, Niigata 951 8122, Japan
    Oncogene 24:399-406. 2005
  7. ncbi request reprint Mtf-1 lymphoma-susceptibility locus affects retention of large thymocytes with high ROS levels in mice after gamma-irradiation
    Masaki Maruyama
    Department of Molecular Genetics, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1 757, Niigata 951 8510, Japan
    Biochem Biophys Res Commun 354:209-15. 2007
  8. ncbi request reprint Involvement of V(D)J recombinase in the generation of intragenic deletions in the Rit1/Bcl11b tumor suppressor gene in gamma-ray-induced thymic lymphomas and in normal thymus of the mouse
    Jun Sakata
    Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1 757, Niigata 951 8122, Japan
    Carcinogenesis 25:1069-75. 2004
  9. doi request reprint Impairment in differentiation and cell cycle of thymocytes by loss of a Bcl11b tumor suppressor allele that contributes to leukemogenesis
    Rieka Go
    Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Leuk Res 36:1035-40. 2012
  10. doi request reprint Clonally expanding thymocytes having lineage capability in gamma-ray-induced mouse atrophic thymus
    Takashi Yamamoto
    Department of Molecular Genetics, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata, Japan
    Int J Radiat Oncol Biol Phys 77:235-43. 2010

Collaborators

  • Ohtsura Niwa
  • Takashi Yamamoto
  • Jun Inoue
  • Yoichi Gondo
  • Kenji Sakimura
  • Hitoshi Ichikawa
  • Hiromichi Yonekawa
  • Shin ichi Morita
  • Yukio Mishima
  • Rieka Go
  • Yoshinori Katsuragi
  • Miki Obata
  • Yutaka Aoyagi
  • Yoshihiro Yoshikai
  • Yasumitsu Kodama
  • Yasushi Tamura
  • Ritsuo Takagi
  • Satoshi Hirose
  • Yuka Morita
  • Yuichi Wakabayashi
  • Masaki Maruyama
  • Tomoyuki Kubota
  • Hitoshi Okumura
  • Jun Sakata
  • Katsuyoshi Hatakeyama
  • Yukie Ochiai
  • Hiroki Sato
  • Sugata Takahashi
  • Tomoyuki Nomura
  • Yuki Kohara
  • Kenya Kamimura
  • Shota Narai
  • Hiroyuki Ohi
  • Yu ichi Wakabayashi
  • Paola Arlotta
  • Tadayuki Togashi
  • Hitomi Kosugi-Okano
  • Atsushi Matsuki
  • Kazunori Shiraishi
  • Tomonori Miyazawa
  • Junko Anraku
  • Hayato Ohshima
  • Atsushi Nishikawa
  • Hiroko Ida-Yonemochi
  • Mitsushiro Nakatomi
  • Yoshiyuki Sakuraba
  • Manabu Abe
  • Kazuyoshi Takizawa
  • Yuki Miyasaka
  • Toshihiro Sato
  • Kiyoshi Okazuka
  • Sachiko Hirokawa
  • Toshihiko Shiroishi
  • Yoshiaki Kikkawa
  • Minesuke Yokoyama
  • Yoshitaka Maeda
  • Hiromi Fujisawa
  • Walter Schaffner
  • Jeffrey D Macklis
  • Jinhui Chen
  • Bradley J Molyneaux
  • Shigeharu Wakana
  • Hisami Watanabe
  • Shinichi Aizawa
  • Toshimitsu Shinbo
  • Naoki Takeda
  • Yoshiaki Takahashi
  • Jiro Hitomi
  • Yuko Saito
  • Masanori Utsuyama
  • Yoshifusa Aizawa
  • Megu Ohtaki
  • Tomoyuki Kitagawa
  • Norio Uematsu
  • Masataka Taga
  • Tsutomu Shimura

Detail Information

Publications27

  1. ncbi request reprint Radiation carcinogenesis in mouse thymic lymphomas
    Ryo Kominami
    Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, and Center for Transdisciplinary Research, Niigata University, 1 757 Asahimachi, Niigata 951 8122
    Cancer Sci 97:575-81. 2006
    ..This paper reviews the indirect mechanism and genes affecting the development of thymic lymphomas that we have analyzed. One is the Bcl11b/Rit1 tumor suppressor gene and the other is Mtf-1 gene affecting tumor susceptibility...
  2. pmc Role of the transcription factor Bcl11b in development and lymphomagenesis
    Ryo Kominami
    Department of Molecular Genetics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 88:72-87. 2012
    ..This review describes phenotypes given by loss of Bcl11b and roles of Bcl11b in cell proliferation, differentiation and apoptosis, taking tissue development and lymphomagenesis into consideration...
  3. ncbi request reprint Haploinsufficiency of Bcl11b for suppression of lymphomagenesis and thymocyte development
    Kenya Kamimura
    Department of Molecular Genetics, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1 757, Niigata 951 8510, Japan
    Biochem Biophys Res Commun 355:538-42. 2007
    ..The haploinsufficiency is further supported by that Bcl11b(+/-) mouse embryos were impaired in thymocyte development and survival. These results indicate relevance of BCL11B aberration to human leukemogenesis...
  4. doi request reprint Effect of Bcl11b genotypes and gamma-radiation on the development of mouse thymic lymphomas
    Yoshihiro Yoshikai
    Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1 757, Chuo Ku, Niigata 951 8510, Japan
    Biochem Biophys Res Commun 373:282-5. 2008
    ..This suggests that the main contribution of irradiation at least in those mice is not for the tumor initiation by inducing allelic losses but probably for the promotion of thymic lymphoma development...
  5. doi request reprint Bcl11b heterozygosity promotes clonal expansion and differentiation arrest of thymocytes in gamma-irradiated mice
    Rieka Go
    Department of Molecular Genetics, Niigata University, Niigata, Japan
    Cancer Sci 101:1347-53. 2010
    ..Collectively, the Bcl11b(KO/+) genotype contributes to clonal expansion and differentiation arrest in part through an increase in the level of beta-catenin...
  6. ncbi request reprint Predisposition to mouse thymic lymphomas in response to ionizing radiation depends on variant alleles encoding metal-responsive transcription factor-1 (Mtf-1)
    Yasushi Tamura
    Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1 757, Niigata 951 8122, Japan
    Oncogene 24:399-406. 2005
    ....
  7. ncbi request reprint Mtf-1 lymphoma-susceptibility locus affects retention of large thymocytes with high ROS levels in mice after gamma-irradiation
    Masaki Maruyama
    Department of Molecular Genetics, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1 757, Niigata 951 8510, Japan
    Biochem Biophys Res Commun 354:209-15. 2007
    ....
  8. ncbi request reprint Involvement of V(D)J recombinase in the generation of intragenic deletions in the Rit1/Bcl11b tumor suppressor gene in gamma-ray-induced thymic lymphomas and in normal thymus of the mouse
    Jun Sakata
    Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1 757, Niigata 951 8122, Japan
    Carcinogenesis 25:1069-75. 2004
    ..Moreover, the recombination frequency was not affected by gamma-irradiation. These results show no effect of radiation on Rit1 mutations and suggest an indirect mechanism for its role in lymphomagenesis...
  9. doi request reprint Impairment in differentiation and cell cycle of thymocytes by loss of a Bcl11b tumor suppressor allele that contributes to leukemogenesis
    Rieka Go
    Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Leuk Res 36:1035-40. 2012
    ..Hence, those phenotypes provided by loss of a Bcl11b allele favor that Bcl11b mutation belongs to type B abnormalities...
  10. doi request reprint Clonally expanding thymocytes having lineage capability in gamma-ray-induced mouse atrophic thymus
    Takashi Yamamoto
    Department of Molecular Genetics, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata, Japan
    Int J Radiat Oncol Biol Phys 77:235-43. 2010
    ..To characterize, in the setting of gamma-ray-induced atrophic thymus, probable prelymphoma cells showing clonal growth and changes in signaling, including DNA damage checkpoint...
  11. ncbi request reprint Expression of TCR alpha beta partly rescues developmental arrest and apoptosis of alpha beta T cells in Bcl11b-/- mice
    Jun Inoue
    Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1 757, Niigata 951 8510, Japan
    J Immunol 176:5871-9. 2006
    ..These results suggest that Bcl11b deficiency affects many different signaling pathways leading to development arrests...
  12. ncbi request reprint The D5Mit7 locus on mouse chromosome 5 provides resistance to gamma-ray-induced but not N-methyl-N-nitrosourea-induced thymic lymphomas
    Yasumitsu Kodama
    Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Japan
    Carcinogenesis 25:143-8. 2004
    ....
  13. ncbi request reprint Comparison of properties of spontaneous and radiation-induced mouse thymic lymphomas: role of Trp53 and radiation
    Tomoyuki Kubota
    Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1 757, Niigata 951 8122, Japan
    Radiat Res 163:159-64. 2005
    ..Furthermore, allelic loss analysis on chromosome 19 localized a region that may harbor an unknown tumor suppressor gene. These results suggest intricate steps of lymphomagenesis influenced by the presence or absence of Trp53...
  14. ncbi request reprint The D4Mit12 locus on mouse chromosome 4 provides susceptibility to both gamma-ray-induced and N-methyl-N-nitrosourea-induced thymic lymphomas
    Hiroki Sato
    Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951 8122, Asahimachi, Japan
    Cancer Sci 94:668-71. 2003
    ..The results strongly suggest that the BALB/c allele near D4Mit12 is associated with susceptibility to lymphomas induced by two carcinogenic agents having different mechanisms of mutagenic action...
  15. ncbi request reprint Mapping of genetic modifiers of thymic lymphoma development in p53-knockout mice
    Yukie Ochiai
    Department of Gene Regulation, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi doori 1 757, Niigata 951 8122, Japan
    Oncogene 22:1098-102. 2003
    ..However, the linkage was not confirmed for Mp53D1 or Mp53D3, suggesting epistasis of genes involved in the tumorigenesis...
  16. ncbi request reprint Bcl11b is required for differentiation and survival of alphabeta T lymphocytes
    Yuichi Wakabayashi
    Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1 757, Niigata 951 8122, Japan
    Nat Immunol 4:533-9. 2003
    ..In addition, we saw profound apoptosis in the thymus of neonatal Bcl11b-/- mice. These results suggest that Bcl11b is a key regulator of both differentiation and survival during thymocyte development...
  17. doi request reprint BCL11B tumor suppressor inhibits HDM2 expression in a p53-dependent manner
    Miki Obata
    Department of Molecular Genetics, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
    Cell Signal 24:1047-52. 2012
    ..These date suggest that BCL11B affects the activity of the p53-HDM2 feedback loop in basal and irradiated conditions. This may be a mechanism underlying the leukemic transformation in T-ALL and in Bcl11b(KO/+)p53(KO/+) mouse thymocytes...
  18. ncbi request reprint Bcl11b heterozygosity leads to age-related hearing loss and degeneration of outer hair cells of the mouse cochlea
    Hitoshi Okumura
    Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, 1 757 Asahimachi, Niigata 951 8510, Japan
    Exp Anim 60:355-61. 2011
    ..These results suggest that the AHL observed in Bcl11b (+/-) mice is the result of impairment of the outer hair cells and that BCL11B activity is required for the maintenance of outer hair cells and normal hearing...
  19. ncbi request reprint Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomas
    Yuichi Wakabayashi
    Department of Gene Regulation, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1 757, Niigata 951 8122, Japan
    Biochem Biophys Res Commun 301:598-603. 2003
    ..Introduction of Rit1 into HeLa cells lacking Rit1 expression suppressed cell growth. These results indicate that loss-of-function mutations of Rit1 contribute to mouse lymphomagenesis and possibly to human cancer development...
  20. doi request reprint Cell of origin in radiation-induced premalignant thymocytes with differentiation capability in mice conditionally losing one Bcl11b allele
    Rieka Go
    Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata, Japan
    Cancer Sci 104:1009-16. 2013
    ..This suggests the existence of a subpopulation of immature cells within the premalignant cells that is capable of proliferating and continuously producing differentiated thymocytes. ..
  21. doi request reprint Bcl11b transcription factor plays a role in the maintenance of the ameloblast-progenitors in mouse adult maxillary incisors
    Yoshinori Katsuragi
    Division of Molecular Biology, Department of Molecular Genetics, Niigata University, Graduate School of Medical and Dental Sciences, Japan
    Mech Dev 130:482-92. 2013
    ..Those data suggest that the incisor maintenance by Bcl11b is not directly related to the FGF epithelial-mesenchymal signaling loop including Shh but is intrinsic to ameloblast progenitors and possibly stem cells. ..
  22. ncbi request reprint Two distinct methods analyzing chromatin structure using centrifugation and antibodies to modified histone H3: both provide similar chromatin states of the Rit1/Bcl11b gene
    Tadayuki Togashi
    Department of Molecular Genetics, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1 757, Niigata 951 8510, Japan
    Biochem Biophys Res Commun 313:489-95. 2004
    ..These results indicate that the centrifugation-based H/E assay should provide a new approach to the regulation of chromatin structure with respect to its condensation state, complementing ChIP assays...
  23. ncbi request reprint Fine mapping of Ahl3 affecting both age-related and noise-induced hearing loss
    Yuka Morita
    Department of Molecular Genetics, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi 1 757, Niigata 951 8510, Japan
    Biochem Biophys Res Commun 355:117-21. 2007
    ..These results indicate that Ahl3 exists within the 14-Mb region and affects not only AHL but also NIHL...
  24. ncbi request reprint Trp53 affects the developmental anomaly of clefts of the palate in irradiated mouse embryos but not clefts of the lip with or without the palate
    Shota Narai
    Department of Molecular Genetics, Niigata University, Asahimachi 1 757, Niigata 951 8510, Japan
    Radiat Res 166:877-82. 2006
    ..These results indicate that Trp53 function adversely affects the development of CPO when certain damaging agents such as radiation are given...
  25. ncbi request reprint Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo
    Paola Arlotta
    MGH HMS Center for Nervous System Repair, Departments of Neurosurgery and Neurology, Program in Neuroscience and Harvard Stem Cell Institute, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuron 45:207-21. 2005
    ....
  26. ncbi request reprint Allelic losses in mouse skin tumors induced by gamma-irradiation of p53 heterozygotes
    Tomonori Miyazawa
    Department of Gene Regulation, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
    Jpn J Cancer Res 93:994-9. 2002
    ..The present study is the first to report a mouse model system useful for the analysis of radiation induction of skin cancer in man...
  27. ncbi request reprint Persistent induction of somatic reversions of the pink-eyed unstable mutation in F1 mice born to fathers irradiated at the spermatozoa stage
    Kazunori Shiraishi
    Department of Late Effect Studies, Radiation Biology Center, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Radiat Res 157:661-7. 2002
    ..The present study demonstrates the presence of a long-lasting memory of DNA damage and the persistent up-regulation of recombinogenic activity in the retinal pigment epithelium of the developing fetus...