Toru Kobayashi

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. Kobayashi T, Washiyama K, Ikeda K. Inhibition of G protein-activated inwardly rectifying K+ channels by fluoxetine (Prozac). Br J Pharmacol. 2003;138:1119-28 pubmed
    ..The present results suggest that inhibition of GIRK channels by fluoxetine may contribute to some of its therapeutic effects and adverse side effects, particularly seizures in overdose, observed in clinical practice. ..
  2. request reprint
    Kobayashi T, Washiyama K, Ikeda K. Inhibition of G protein-activated inwardly rectifying K+ channels by the antidepressant paroxetine. J Pharmacol Sci. 2006;102:278-87 pubmed
    ..Our results suggest that inhibition of GIRK channels by paroxetine may contribute partly to some of its therapeutic effects and adverse side effects. ..
  3. Kobayashi T, Washiyama K, Ikeda K. Pregnenolone sulfate potentiates the inwardly rectifying K channel Kir2.3. PLoS ONE. 2009;4:e6311 pubmed publisher
    ..3-containing Kir2 heteromeric channels. The present results suggest that PREGS acts as a positive modulator of Kir2.3 channels. Kir2.3 channel potentiation may provide novel insights into the various effects of PREGS. ..
  4. Kobayashi T, Washiyama K, Ikeda K. Inhibition of G protein-activated inwardly rectifying K+ channels by different classes of antidepressants. PLoS ONE. 2011;6:e28208 pubmed publisher
    ..The present results suggest that GIRK channel inhibition may reveal a novel characteristic of the commonly used antidepressants, particularly sertraline, and contributes to some of the therapeutic effects and adverse effects. ..
  5. Kobayashi T, Hirai H, Iino M, Fuse I, Mitsumura K, Washiyama K, et al. Inhibitory effects of the antiepileptic drug ethosuximide on G protein-activated inwardly rectifying K+ channels. Neuropharmacology. 2009;56:499-506 pubmed publisher
    ..These results suggest that the inhibitory effects of ethosuximide on GIRK channels may affect some of brain, heart and platelet functions. ..
  6. Kobayashi T, Washiyama K, Ikeda K. Inhibition of G-protein-activated inwardly rectifying K+ channels by the selective norepinephrine reuptake inhibitors atomoxetine and reboxetine. Neuropsychopharmacology. 2010;35:1560-9 pubmed publisher
    ..GIRK channel inhibition may contribute to some of the therapeutic effects of NRIs and adverse side effects related to nervous system and heart function. ..