Research Topics
| S KitagawaSummaryAffiliation: Niigata University of Pharmacy and Applied Life Sciences Country: Japan Publications
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Detail Information
Publications
Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cellsShuji Kitagawa
Niigata University of Pharmacy and Applied Life Sciences, Japan
Biol Pharm Bull 28:2274-8. 2005..These results suggested that hydrophobicity as well as planar structure is important for the inhibitory effects of flavonoids on P-gp-mediated transport...- Inhibitory effects of polyphenols on p-glycoprotein-mediated transportShuji Kitagawa
Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
Biol Pharm Bull 29:1-6. 2006..This is a review of our recent investigations using multidrug-resistant P-gp overexpressing KB-C2 cells... - Inhibitory effects of flavonoids on free radical-induced hemolysis and their oxidative effects on hemoglobinShuji Kitagawa
Niigata University of Pharmacy and Applied Life Sciences, Faculty of Pharmaceutical Sciences, Niigata, Japan
Chem Pharm Bull (Tokyo) 52:999-1001. 2004..However, this oxidation did not induce hemolysis. These findings indicate that relatively hydrophobic flavonoids penetrate the cytoplasm of erythrocytes, interact with hemoglobin, and oxidize the heme iron... - Inhibition of P-glycoprotein function by tea catechins in KB-C2 cellsShuji Kitagawa
Niigata University of Pharmacy and Applied Life Sciences, Kamishin ei cho 5 13 2, 950 2081, Japan
J Pharm Pharmacol 56:1001-5. 2004.... - Cationic vesicles consisting of 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) and phosphatidylcholines and their interaction with erythrocyte membraneShuji Kitagawa
Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan
Chem Pharm Bull (Tokyo) 52:451-3. 2004.... - Enhanced delivery of retinoic acid to skin by cationic liposomesShuji Kitagawa
Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan
Chem Pharm Bull (Tokyo) 54:242-4. 2006..These results suggest the potential of the use of the cationic liposomes for the intradermal delivery of lipophilic drugs like retinoic acid... - Enhanced skin permeation of cationic drug ketotifen through excised guinea pig dorsal skin by surfactants with different electric chargesShuji Kitagawa
Niigata University of Pharmacy and Applied Life Sciences, Faculty of Pharmaceutical Sciences, Japan
Chem Pharm Bull (Tokyo) 51:1183-5. 2003..Analysis of the retention of ketotifen in the skin suggested that SDS-induced increase in the transfer of hydrophilic ketotifen to the skin is the main reason for the marked increase in skin permeation... - Transbilayer transport of a propyltrimethylammonium derivative of diphenylhexatriene (TMAP-DPH) in bovine blood platelets and adrenal chromaffin cellsShuji Kitagawa
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Kamishin ei cho 5 13 2, Niigata 950 2081, Japan
J Pharm Pharmacol 54:1631-6. 2002..The saturation phenomenon suggested the presence of the regulatory process in the transbilayer transport of TMAP-DPH... - Inhibitory effects of ginsenosides and their hydrolyzed metabolites on daunorubicin transport in KB-C2 cellsShuji Kitagawa
Kobe Pharmaceutical University, Kobe, Japan
Biol Pharm Bull 30:1979-81. 2007..Analysis of verapamil-stimulated ATPase activity in membrane vesicles expressing human P-gp suggested that the increased daunorubicin accumulation by M4 was at least partly due to ATPase inhibition of P-gp... - Effects of alkyl gallates on P-glycoprotein functionShuji Kitagawa
Laboratory of Pharmaceutics, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan
Biochem Pharmacol 70:1262-6. 2005..The cytotoxicity of daunorubicin was recovered in the presence of alkyl gallates possibly due to their inhibition of P-gp function... - Asymmetrical membrane fluidity of bovine adrenal chromaffin cells and granules and effect of trichosporin-B-VIaS Kitagawa
Niigata College of Pharmacy, Kamishin ei cho 5 13 2, Niigata 950 2081, Japan
Biochim Biophys Acta 1375:93-100. 1998.... - Effects of n-alkyltrimethylammonium on skin permeation of benzoic acid through excised guinea pig dorsal skinS Kitagawa
Niigata College of Pharmacy, Japan
Chem Pharm Bull (Tokyo) 48:1698-701. 2000.... - Analysis of electron spin resonance spectra of alkyl spin labels in excised guinea pig dorsal skin, its stratum corneum, delipidized skin and stratum corneum model lipid liposomesS Kitagawa
Niigata College of Pharmacy, Japan
Chem Pharm Bull (Tokyo) 49:165-8. 2001..These findings indicated that the different interaction and different localization of the alkyl spin labels depended on their electronic charge as well as their alkyl chain lengths... - Effects of double-chained cationic surfactants n-dimethyldialkylammoniums on skin permeation of benzoic acid through excised guinea pig dorsal skin: comparison of their enhancement effects with hemolytic effects on erythrocytesS Kitagawa
Niigata College of Pharmacy, Japan
Chem Pharm Bull (Tokyo) 49:1155-8. 2001..Their enhancement mechanism is possibly similar to that of single-chained cationic surfactants... - Interaction of double-chained cationic surfactants, dimethyldialkylammoniums, with erythrocyte membranes: stabilization of the cationic vesicles by phosphatidylcholines with unsaturated fatty acyl chainsShuji Kitagawa
Nigata University of Pharmacy and Applied Life Sciences, Faculty of Pharmaceutical Sciences, Japan
J Pharm Pharmacol 54:773-80. 2002.... 
Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicalsTomohiro Nabekura
Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Higashi jima, Akiha ku, Niigata 956 8603, Japan
Cancer Chemother Pharmacol 62:867-73. 2008....- Inhibition of anticancer drug efflux transporter P-glycoprotein by rosemary phytochemicalsTomohiro Nabekura
Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Higashi jima, Akiha ku, Niigata 956 8603, Japan
Pharmacol Res 61:259-63. 2010..These results suggest that rosemary phytochemicals, such as carnosic acid, have inhibitory effects on anticancer drug efflux transporter P-glycoprotein and may become useful to enhance the efficacy of cancer chemotherapy... - Effect of triterpenoids isolated from the floral spikes of Betula platyphylla var. japonica on P-glycoprotein functionMichiko Sekiya
Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
Planta Med 73:1558-62. 2007..In addition, compounds 13 and 20 showed a weak inhibitory activity of P-gp ATPase. These results suggested that MDR reversing effects of compounds 13 and 20 are partly involved in inhibition of P-gp ATPase... - Assessment of tear concentrations on therapeutic drug monitoring. II. Pharmacokinetic analysis of valproic acid in guinea pig serum, cerebrospinal fluid, and tearsS Sato
Department of Pharmaceutics, Niigata College of Pharmacy, Japan
Pharm Res 18:500-9. 2001.... - Effects of dietary chemopreventive phytochemicals on P-glycoprotein functionTomohiro Nabekura
Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
Biochem Biophys Res Commun 327:866-70. 2005..These results suggest that dietary phytochemicals, such as capsaicin, curcumin, [6]-gingerol, and resveratrol, have inhibitory effects on P-glycoprotein and potencies to cause drug-food interactions... - Changes in plasma membrane Ca2+ -ATPase expression and ATP content in lenses of hereditary cataract UPL ratsTomohiro Nabekura
Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Kamishin ei cho, Niigata 950 2081, Japan
Toxicology 197:177-83. 2004..Disulfiram and aminoguanidine attenuate the decrease in ATP, resulting in a delay in cataract development... - Transport of trace elements in lenses of normal and hereditary cataract UPL ratsTomohiro Nabekura
Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Kamishin ei cho, Niigata, 950 2081, Japan
Toxicology 191:227-32. 2003..The different transport characteristics of trace elements in the lenses of normal and UPL cataract rats, especially the higher accumulation of Se in UPL rat lenses, may be implicated in cataract development... - Enhanced skin delivery of quercetin by microemulsionShuji Kitagawa
Kobe Pharmaceutical University, Kobe, Japan
J Pharm Pharmacol 61:855-60. 2009..The aim of this study was to determine the usefulness of a microemulsion for that purpose... - Inhibition of P-glycoprotein function by tannic acid and pentagalloylglucoseShuji Kitagawa
Kobe Pharmaceutical University, Motoyamakita machi 4 19 1, Kobe 658 8558, Japan
J Pharm Pharmacol 59:965-9. 2007..The findings also suggested that the presence of a large number of galloyl groups in polyphenols strengthens the interaction with regulatory regions in P-gp... - Effects of chemopreventive citrus phytochemicals on human P-glycoprotein and multidrug resistance protein 1Tomohiro Nabekura
Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
Eur J Pharmacol 600:45-9. 2008..These results suggest that chemopreventive citrus phytochemicals, such as nobiletin found in oranges, have inhibitory effects on P-glycoprotein and/or MRP1, and may cause food-drug interactions... - Permeability of ionized salicylate derivatives through guinea pig dorsal skinMohammad Abu Hena Mostofa Kamal
Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
Chem Pharm Bull (Tokyo) 53:441-3. 2005..These findings suggested that the ionic permeation pathway of salicylate derivatives is controlled by hydrophobic as well as hydrophilic properties... - Enhanced skin delivery of genistein and other two isoflavones by microemulsion and prevention against UV irradiation-induced erythema formationShuji Kitagawa
Kobe Pharmaceutical University, Kobe 658 8558, Japan
Chem Pharm Bull (Tokyo) 58:398-401. 2010..These findings indicate the potential use of w/o-type microemulsion for the delivery of genistein to protect skin against UV-induced oxidative damage... - Effects of plant sterols on human multidrug transporters ABCB1 and ABCC1Tomohiro Nabekura
Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Higashi jima, Akiha ku, Niigata 956 8603, Japan
Biochem Biophys Res Commun 369:363-8. 2008..These results suggest that guggulsterone, a natural dietary hypolipidemic agent have dual inhibitory effects on P-gp and MRP1 and the potencies to cause food-drug interactions... - Enhanced skin permeation of diclofenac by ion-pair formation and further enhancement by microemulsionMohammad Abu Hena Mostofa Kamal
Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
Chem Pharm Bull (Tokyo) 55:368-71. 2007..The present findings suggest the usefulness of combined use of ion-pairs with microemulsions for enhancement of skin permeation of ionic drugs... - Enhanced skin permeation of salicylate by ion-pair formation in non-aqueous vehicle and further enhancement by ethanol and l-mentholMohammad Abu Hena Mostofa Kamal
Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan
Chem Pharm Bull (Tokyo) 54:481-4. 2006.... - pH-dependent inhibitory effects of angiotensin-converting enzyme inhibitors on cefroxadine uptake by rabbit small intestinal brush-border membrane vesicles and their relationship with hydrophobicity and the ratio of zwitterionic speciesS Kitagawa
Niigata College of Pharmacy, Japan
Biol Pharm Bull 22:721-4. 1999..0. Regression analysis of the inhibitory effects suggested that the affinity of these ACE inhibitors for the transporter was regulated by the hydrophobicity of these ACE inhibitors and the ratio of the zwitterionic species of the drugs... - Method for optical resolution of racemic homochlorcyclizine and comparison of optical isomers in antihistamine activity and pharmacokineticsM Nishikata
Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
Chem Pharm Bull (Tokyo) 40:1341-2. 1992..The pharmacokinetics of d- and l-HCZ after oral administration to rats also differed. The successful resolution of racemic HCZ permits comparison of the pharmacokinetics and antihistamine activity of the enantiomers... - Physicochemical properties of tamoxifen hemicitrate sesquihydrateTakashi Kojima
Department of Pharmaceutical Technology, Kobe Pharmaceutical University, Higashinada, Kobe 658 8558, Japan
Int J Pharm 352:146-51. 2008.... 
Enzymatic measurement of phosphatidic acid in cultured cellsShin ya Morita
Laboratory of Pharmaceutical Technology, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
J Lipid Res 50:1945-52. 2009..This novel method for PA quantification is simple, rapid, specific, sensitive, and high-throughput and will help to study the biological functions of PA and its related enzymes...- Effect of spectroscopic properties on photostability of tamoxifen citrate polymorphsTakashi Kojima
Department of Pharmaceutical Technology, Kobe Pharmaceutical University, Higashi Nada, Kobe 658 8558, Japan
Int J Pharm 336:346-51. 2007..The results obtained suggested that the photodegradation followed by surface color change of form A crystal was caused by the selective absorption of photoenergy of UVA light irradiated by a xenon lamp... - Effect of pharmaceutical excipients on the stability of trichlormethiazide tablets under humid conditionsReiko Teraoka
Department of Pharmaceutical Technology, Kobe Pharmaceutical University, Motoyama Kitamachi, Higashi Nada, Japan
Chem Pharm Bull (Tokyo) 57:1343-7. 2009..It was found that the TCM content decreased significantly in a binary mixture of TCM/HPC 1 : 1... - Enhancement effects of double-chained cationic surfactants of n-dimethyldialkylammoniums on permeability of salicylate through guinea pig dorsal skinShuji Kitagawa
Niigata University of Pharmacy and Applied Life Sciences, Faculty of Pharmaceutical Sciences Japan
Chem Pharm Bull (Tokyo) 50:1370-2. 2002.... - Triterpenoids from the floral spikes of Betula platyphylla var. japonica and their reversing activity against multidrug-resistant cancer cellsYoshiki Kashiwada
Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1 78, Tokushima 770 8505, Japan
J Nat Prod 70:623-7. 2007..Compound 10 reversed the cytotoxicity of colchicine against KB-C2 cells at 8.1 microM and showed comparable potency to 5 microM verapamil...