S Kitagawa

Summary

Affiliation: Niigata University of Pharmacy and Applied Life Sciences
Country: Japan

Publications

  1. ncbi request reprint Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells
    Shuji Kitagawa
    Niigata University of Pharmacy and Applied Life Sciences, Japan
    Biol Pharm Bull 28:2274-8. 2005
  2. ncbi request reprint Inhibitory effects of polyphenols on p-glycoprotein-mediated transport
    Shuji Kitagawa
    Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Biol Pharm Bull 29:1-6. 2006
  3. ncbi request reprint Inhibitory effects of flavonoids on free radical-induced hemolysis and their oxidative effects on hemoglobin
    Shuji Kitagawa
    Niigata University of Pharmacy and Applied Life Sciences, Faculty of Pharmaceutical Sciences, Niigata, Japan
    Chem Pharm Bull (Tokyo) 52:999-1001. 2004
  4. ncbi request reprint Inhibition of P-glycoprotein function by tea catechins in KB-C2 cells
    Shuji Kitagawa
    Niigata University of Pharmacy and Applied Life Sciences, Kamishin ei cho 5 13 2, 950 2081, Japan
    J Pharm Pharmacol 56:1001-5. 2004
  5. ncbi request reprint Cationic vesicles consisting of 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) and phosphatidylcholines and their interaction with erythrocyte membrane
    Shuji Kitagawa
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan
    Chem Pharm Bull (Tokyo) 52:451-3. 2004
  6. ncbi request reprint Enhanced delivery of retinoic acid to skin by cationic liposomes
    Shuji Kitagawa
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan
    Chem Pharm Bull (Tokyo) 54:242-4. 2006
  7. ncbi request reprint Enhanced skin permeation of cationic drug ketotifen through excised guinea pig dorsal skin by surfactants with different electric charges
    Shuji Kitagawa
    Niigata University of Pharmacy and Applied Life Sciences, Faculty of Pharmaceutical Sciences, Japan
    Chem Pharm Bull (Tokyo) 51:1183-5. 2003
  8. ncbi request reprint Transbilayer transport of a propyltrimethylammonium derivative of diphenylhexatriene (TMAP-DPH) in bovine blood platelets and adrenal chromaffin cells
    Shuji Kitagawa
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Kamishin ei cho 5 13 2, Niigata 950 2081, Japan
    J Pharm Pharmacol 54:1631-6. 2002
  9. ncbi request reprint Inhibitory effects of ginsenosides and their hydrolyzed metabolites on daunorubicin transport in KB-C2 cells
    Shuji Kitagawa
    Kobe Pharmaceutical University, Kobe, Japan
    Biol Pharm Bull 30:1979-81. 2007
  10. ncbi request reprint Effects of alkyl gallates on P-glycoprotein function
    Shuji Kitagawa
    Laboratory of Pharmaceutics, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan
    Biochem Pharmacol 70:1262-6. 2005

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells
    Shuji Kitagawa
    Niigata University of Pharmacy and Applied Life Sciences, Japan
    Biol Pharm Bull 28:2274-8. 2005
    ..These results suggested that hydrophobicity as well as planar structure is important for the inhibitory effects of flavonoids on P-gp-mediated transport...
  2. ncbi request reprint Inhibitory effects of polyphenols on p-glycoprotein-mediated transport
    Shuji Kitagawa
    Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Biol Pharm Bull 29:1-6. 2006
    ..This is a review of our recent investigations using multidrug-resistant P-gp overexpressing KB-C2 cells...
  3. ncbi request reprint Inhibitory effects of flavonoids on free radical-induced hemolysis and their oxidative effects on hemoglobin
    Shuji Kitagawa
    Niigata University of Pharmacy and Applied Life Sciences, Faculty of Pharmaceutical Sciences, Niigata, Japan
    Chem Pharm Bull (Tokyo) 52:999-1001. 2004
    ..However, this oxidation did not induce hemolysis. These findings indicate that relatively hydrophobic flavonoids penetrate the cytoplasm of erythrocytes, interact with hemoglobin, and oxidize the heme iron...
  4. ncbi request reprint Inhibition of P-glycoprotein function by tea catechins in KB-C2 cells
    Shuji Kitagawa
    Niigata University of Pharmacy and Applied Life Sciences, Kamishin ei cho 5 13 2, 950 2081, Japan
    J Pharm Pharmacol 56:1001-5. 2004
    ....
  5. ncbi request reprint Cationic vesicles consisting of 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) and phosphatidylcholines and their interaction with erythrocyte membrane
    Shuji Kitagawa
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan
    Chem Pharm Bull (Tokyo) 52:451-3. 2004
    ....
  6. ncbi request reprint Enhanced delivery of retinoic acid to skin by cationic liposomes
    Shuji Kitagawa
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan
    Chem Pharm Bull (Tokyo) 54:242-4. 2006
    ..These results suggest the potential of the use of the cationic liposomes for the intradermal delivery of lipophilic drugs like retinoic acid...
  7. ncbi request reprint Enhanced skin permeation of cationic drug ketotifen through excised guinea pig dorsal skin by surfactants with different electric charges
    Shuji Kitagawa
    Niigata University of Pharmacy and Applied Life Sciences, Faculty of Pharmaceutical Sciences, Japan
    Chem Pharm Bull (Tokyo) 51:1183-5. 2003
    ..Analysis of the retention of ketotifen in the skin suggested that SDS-induced increase in the transfer of hydrophilic ketotifen to the skin is the main reason for the marked increase in skin permeation...
  8. ncbi request reprint Transbilayer transport of a propyltrimethylammonium derivative of diphenylhexatriene (TMAP-DPH) in bovine blood platelets and adrenal chromaffin cells
    Shuji Kitagawa
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Kamishin ei cho 5 13 2, Niigata 950 2081, Japan
    J Pharm Pharmacol 54:1631-6. 2002
    ..The saturation phenomenon suggested the presence of the regulatory process in the transbilayer transport of TMAP-DPH...
  9. ncbi request reprint Inhibitory effects of ginsenosides and their hydrolyzed metabolites on daunorubicin transport in KB-C2 cells
    Shuji Kitagawa
    Kobe Pharmaceutical University, Kobe, Japan
    Biol Pharm Bull 30:1979-81. 2007
    ..Analysis of verapamil-stimulated ATPase activity in membrane vesicles expressing human P-gp suggested that the increased daunorubicin accumulation by M4 was at least partly due to ATPase inhibition of P-gp...
  10. ncbi request reprint Effects of alkyl gallates on P-glycoprotein function
    Shuji Kitagawa
    Laboratory of Pharmaceutics, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan
    Biochem Pharmacol 70:1262-6. 2005
    ..The cytotoxicity of daunorubicin was recovered in the presence of alkyl gallates possibly due to their inhibition of P-gp function...
  11. ncbi request reprint Asymmetrical membrane fluidity of bovine adrenal chromaffin cells and granules and effect of trichosporin-B-VIa
    S Kitagawa
    Niigata College of Pharmacy, Kamishin ei cho 5 13 2, Niigata 950 2081, Japan
    Biochim Biophys Acta 1375:93-100. 1998
    ....
  12. ncbi request reprint Effects of n-alkyltrimethylammonium on skin permeation of benzoic acid through excised guinea pig dorsal skin
    S Kitagawa
    Niigata College of Pharmacy, Japan
    Chem Pharm Bull (Tokyo) 48:1698-701. 2000
    ....
  13. ncbi request reprint Analysis of electron spin resonance spectra of alkyl spin labels in excised guinea pig dorsal skin, its stratum corneum, delipidized skin and stratum corneum model lipid liposomes
    S Kitagawa
    Niigata College of Pharmacy, Japan
    Chem Pharm Bull (Tokyo) 49:165-8. 2001
    ..These findings indicated that the different interaction and different localization of the alkyl spin labels depended on their electronic charge as well as their alkyl chain lengths...
  14. ncbi request reprint Effects of double-chained cationic surfactants n-dimethyldialkylammoniums on skin permeation of benzoic acid through excised guinea pig dorsal skin: comparison of their enhancement effects with hemolytic effects on erythrocytes
    S Kitagawa
    Niigata College of Pharmacy, Japan
    Chem Pharm Bull (Tokyo) 49:1155-8. 2001
    ..Their enhancement mechanism is possibly similar to that of single-chained cationic surfactants...
  15. ncbi request reprint Interaction of double-chained cationic surfactants, dimethyldialkylammoniums, with erythrocyte membranes: stabilization of the cationic vesicles by phosphatidylcholines with unsaturated fatty acyl chains
    Shuji Kitagawa
    Nigata University of Pharmacy and Applied Life Sciences, Faculty of Pharmaceutical Sciences, Japan
    J Pharm Pharmacol 54:773-80. 2002
    ....
  16. doi request reprint Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicals
    Tomohiro Nabekura
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Higashi jima, Akiha ku, Niigata 956 8603, Japan
    Cancer Chemother Pharmacol 62:867-73. 2008
    ....
  17. doi request reprint Inhibition of anticancer drug efflux transporter P-glycoprotein by rosemary phytochemicals
    Tomohiro Nabekura
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Higashi jima, Akiha ku, Niigata 956 8603, Japan
    Pharmacol Res 61:259-63. 2010
    ..These results suggest that rosemary phytochemicals, such as carnosic acid, have inhibitory effects on anticancer drug efflux transporter P-glycoprotein and may become useful to enhance the efficacy of cancer chemotherapy...
  18. ncbi request reprint Effect of triterpenoids isolated from the floral spikes of Betula platyphylla var. japonica on P-glycoprotein function
    Michiko Sekiya
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Planta Med 73:1558-62. 2007
    ..In addition, compounds 13 and 20 showed a weak inhibitory activity of P-gp ATPase. These results suggested that MDR reversing effects of compounds 13 and 20 are partly involved in inhibition of P-gp ATPase...
  19. ncbi request reprint Assessment of tear concentrations on therapeutic drug monitoring. II. Pharmacokinetic analysis of valproic acid in guinea pig serum, cerebrospinal fluid, and tears
    S Sato
    Department of Pharmaceutics, Niigata College of Pharmacy, Japan
    Pharm Res 18:500-9. 2001
    ....
  20. ncbi request reprint Effects of dietary chemopreventive phytochemicals on P-glycoprotein function
    Tomohiro Nabekura
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Biochem Biophys Res Commun 327:866-70. 2005
    ..These results suggest that dietary phytochemicals, such as capsaicin, curcumin, [6]-gingerol, and resveratrol, have inhibitory effects on P-glycoprotein and potencies to cause drug-food interactions...
  21. ncbi request reprint Changes in plasma membrane Ca2+ -ATPase expression and ATP content in lenses of hereditary cataract UPL rats
    Tomohiro Nabekura
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Kamishin ei cho, Niigata 950 2081, Japan
    Toxicology 197:177-83. 2004
    ..Disulfiram and aminoguanidine attenuate the decrease in ATP, resulting in a delay in cataract development...
  22. ncbi request reprint Transport of trace elements in lenses of normal and hereditary cataract UPL rats
    Tomohiro Nabekura
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Kamishin ei cho, Niigata, 950 2081, Japan
    Toxicology 191:227-32. 2003
    ..The different transport characteristics of trace elements in the lenses of normal and UPL cataract rats, especially the higher accumulation of Se in UPL rat lenses, may be implicated in cataract development...
  23. doi request reprint Enhanced skin delivery of quercetin by microemulsion
    Shuji Kitagawa
    Kobe Pharmaceutical University, Kobe, Japan
    J Pharm Pharmacol 61:855-60. 2009
    ..The aim of this study was to determine the usefulness of a microemulsion for that purpose...
  24. ncbi request reprint Inhibition of P-glycoprotein function by tannic acid and pentagalloylglucose
    Shuji Kitagawa
    Kobe Pharmaceutical University, Motoyamakita machi 4 19 1, Kobe 658 8558, Japan
    J Pharm Pharmacol 59:965-9. 2007
    ..The findings also suggested that the presence of a large number of galloyl groups in polyphenols strengthens the interaction with regulatory regions in P-gp...
  25. doi request reprint Effects of chemopreventive citrus phytochemicals on human P-glycoprotein and multidrug resistance protein 1
    Tomohiro Nabekura
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Eur J Pharmacol 600:45-9. 2008
    ..These results suggest that chemopreventive citrus phytochemicals, such as nobiletin found in oranges, have inhibitory effects on P-glycoprotein and/or MRP1, and may cause food-drug interactions...
  26. ncbi request reprint Permeability of ionized salicylate derivatives through guinea pig dorsal skin
    Mohammad Abu Hena Mostofa Kamal
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Chem Pharm Bull (Tokyo) 53:441-3. 2005
    ..These findings suggested that the ionic permeation pathway of salicylate derivatives is controlled by hydrophobic as well as hydrophilic properties...
  27. ncbi request reprint Enhanced skin delivery of genistein and other two isoflavones by microemulsion and prevention against UV irradiation-induced erythema formation
    Shuji Kitagawa
    Kobe Pharmaceutical University, Kobe 658 8558, Japan
    Chem Pharm Bull (Tokyo) 58:398-401. 2010
    ..These findings indicate the potential use of w/o-type microemulsion for the delivery of genistein to protect skin against UV-induced oxidative damage...
  28. doi request reprint Effects of plant sterols on human multidrug transporters ABCB1 and ABCC1
    Tomohiro Nabekura
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Higashi jima, Akiha ku, Niigata 956 8603, Japan
    Biochem Biophys Res Commun 369:363-8. 2008
    ..These results suggest that guggulsterone, a natural dietary hypolipidemic agent have dual inhibitory effects on P-gp and MRP1 and the potencies to cause food-drug interactions...
  29. ncbi request reprint Enhanced skin permeation of diclofenac by ion-pair formation and further enhancement by microemulsion
    Mohammad Abu Hena Mostofa Kamal
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Chem Pharm Bull (Tokyo) 55:368-71. 2007
    ..The present findings suggest the usefulness of combined use of ion-pairs with microemulsions for enhancement of skin permeation of ionic drugs...
  30. ncbi request reprint Enhanced skin permeation of salicylate by ion-pair formation in non-aqueous vehicle and further enhancement by ethanol and l-menthol
    Mohammad Abu Hena Mostofa Kamal
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan
    Chem Pharm Bull (Tokyo) 54:481-4. 2006
    ....
  31. ncbi request reprint pH-dependent inhibitory effects of angiotensin-converting enzyme inhibitors on cefroxadine uptake by rabbit small intestinal brush-border membrane vesicles and their relationship with hydrophobicity and the ratio of zwitterionic species
    S Kitagawa
    Niigata College of Pharmacy, Japan
    Biol Pharm Bull 22:721-4. 1999
    ..0. Regression analysis of the inhibitory effects suggested that the affinity of these ACE inhibitors for the transporter was regulated by the hydrophobicity of these ACE inhibitors and the ratio of the zwitterionic species of the drugs...
  32. ncbi request reprint Method for optical resolution of racemic homochlorcyclizine and comparison of optical isomers in antihistamine activity and pharmacokinetics
    M Nishikata
    Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Chem Pharm Bull (Tokyo) 40:1341-2. 1992
    ..The pharmacokinetics of d- and l-HCZ after oral administration to rats also differed. The successful resolution of racemic HCZ permits comparison of the pharmacokinetics and antihistamine activity of the enantiomers...
  33. ncbi request reprint Physicochemical properties of tamoxifen hemicitrate sesquihydrate
    Takashi Kojima
    Department of Pharmaceutical Technology, Kobe Pharmaceutical University, Higashinada, Kobe 658 8558, Japan
    Int J Pharm 352:146-51. 2008
    ....
  34. pmc Enzymatic measurement of phosphatidic acid in cultured cells
    Shin ya Morita
    Laboratory of Pharmaceutical Technology, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
    J Lipid Res 50:1945-52. 2009
    ..This novel method for PA quantification is simple, rapid, specific, sensitive, and high-throughput and will help to study the biological functions of PA and its related enzymes...
  35. ncbi request reprint Effect of spectroscopic properties on photostability of tamoxifen citrate polymorphs
    Takashi Kojima
    Department of Pharmaceutical Technology, Kobe Pharmaceutical University, Higashi Nada, Kobe 658 8558, Japan
    Int J Pharm 336:346-51. 2007
    ..The results obtained suggested that the photodegradation followed by surface color change of form A crystal was caused by the selective absorption of photoenergy of UVA light irradiated by a xenon lamp...
  36. ncbi request reprint Effect of pharmaceutical excipients on the stability of trichlormethiazide tablets under humid conditions
    Reiko Teraoka
    Department of Pharmaceutical Technology, Kobe Pharmaceutical University, Motoyama Kitamachi, Higashi Nada, Japan
    Chem Pharm Bull (Tokyo) 57:1343-7. 2009
    ..It was found that the TCM content decreased significantly in a binary mixture of TCM/HPC 1 : 1...
  37. ncbi request reprint Enhancement effects of double-chained cationic surfactants of n-dimethyldialkylammoniums on permeability of salicylate through guinea pig dorsal skin
    Shuji Kitagawa
    Niigata University of Pharmacy and Applied Life Sciences, Faculty of Pharmaceutical Sciences Japan
    Chem Pharm Bull (Tokyo) 50:1370-2. 2002
    ....
  38. ncbi request reprint Triterpenoids from the floral spikes of Betula platyphylla var. japonica and their reversing activity against multidrug-resistant cancer cells
    Yoshiki Kashiwada
    Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1 78, Tokushima 770 8505, Japan
    J Nat Prod 70:623-7. 2007
    ..Compound 10 reversed the cytotoxicity of colchicine against KB-C2 cells at 8.1 microM and showed comparable potency to 5 microM verapamil...