Hiroyuki Kawashima

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. ncbi request reprint Successful surgical treatment of angiosarcoma of the spine: a case report
    Hiroyuki Kawashima
    Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, Japan
    Spine (Phila Pa 1976) 29:E280-3. 2004
  2. ncbi request reprint Ossifying fibromyxoid tumor of soft parts with clonal chromosomal aberrations
    Hiroyuki Kawashima
    Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510 Japan
    Cancer Genet Cytogenet 176:156-60. 2007
  3. ncbi request reprint Expression of the coxsackievirus and adenovirus receptor in musculoskeletal tumors and mesenchymal tissues: efficacy of adenoviral gene therapy for osteosarcoma
    Hiroyuki Kawashima
    Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 Asahimachi dori, Niigata 951 8510
    Cancer Sci 94:70-5. 2003
  4. ncbi request reprint Establishment of novel human dedifferentiated chondrosarcoma cell line with osteoblastic differentiation
    Naoko Kudo
    Division of Orthopaedic Surgery, Department of Regenerative Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, 757 1 Asahimachi dori Ichiban cho, Niigata City, Niigata, 951 8510, Japan
    Virchows Arch 451:691-9. 2007
  5. ncbi request reprint PIASxbeta is a key regulator of osterix transcriptional activity and matrix mineralization in osteoblasts
    Md Moksed Ali
    Division of Cell Biology and Molecular Pharmacology, Niigata University Graduate School of Medical and Dental Sciences, 2 5274 Gakkocho dori, Niigata City, Niigata 951 8514, Japan
    J Cell Sci 120:2565-73. 2007
  6. pmc Chondromodulin-1 directly suppresses growth of human cancer cells
    Hisashi Mera
    Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    BMC Cancer 9:166. 2009
  7. doi request reprint Serum CA 125 expression as a tumor marker for diagnosis and monitoring the clinical course of epithelioid sarcoma
    Makiko Hoshino
    Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 Asahimachi dori, Chuo Ku, Niigata, 951 8510, Japan
    J Cancer Res Clin Oncol 136:457-64. 2010
  8. pmc Homeobox protein MSX2 acts as a molecular defense mechanism for preventing ossification in ligament fibroblasts
    Tatsuya Yoshizawa
    Divisions of Cell Biology and Molecular Pharmacology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Mol Cell Biol 24:3460-72. 2004
  9. ncbi request reprint Activating Gs a mutation rarely occurs in musculoskeletal tumors other than fibrous dysplasia
    Wenguang Gu
    Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, 951 8510, Japan
    Anticancer Res 26:1611-4. 2006
  10. ncbi request reprint Frequent absence of tumor suppressor FUS1 protein expression in human bone and soft tissue sarcomas
    Guidong Li
    Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Niigata, Japan
    Anticancer Res 31:11-21. 2011

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Successful surgical treatment of angiosarcoma of the spine: a case report
    Hiroyuki Kawashima
    Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, Japan
    Spine (Phila Pa 1976) 29:E280-3. 2004
    ..Case report...
  2. ncbi request reprint Ossifying fibromyxoid tumor of soft parts with clonal chromosomal aberrations
    Hiroyuki Kawashima
    Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510 Japan
    Cancer Genet Cytogenet 176:156-60. 2007
    ..Combined with several previously reported studies, these aberrations could not identify a common cytogenetic abnormality in OFMT...
  3. ncbi request reprint Expression of the coxsackievirus and adenovirus receptor in musculoskeletal tumors and mesenchymal tissues: efficacy of adenoviral gene therapy for osteosarcoma
    Hiroyuki Kawashima
    Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 Asahimachi dori, Niigata 951 8510
    Cancer Sci 94:70-5. 2003
    ..Most osteosarcomas appeared to express high levels of CAR, and thus adenovirus-mediated p53 gene therapy is likely to be suitable for the treatment of such tumors...
  4. ncbi request reprint Establishment of novel human dedifferentiated chondrosarcoma cell line with osteoblastic differentiation
    Naoko Kudo
    Division of Orthopaedic Surgery, Department of Regenerative Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, 757 1 Asahimachi dori Ichiban cho, Niigata City, Niigata, 951 8510, Japan
    Virchows Arch 451:691-9. 2007
    ..To our knowledge, this is the first report of the establishment of a human dedifferentiated chondrosarcoma...
  5. ncbi request reprint PIASxbeta is a key regulator of osterix transcriptional activity and matrix mineralization in osteoblasts
    Md Moksed Ali
    Division of Cell Biology and Molecular Pharmacology, Niigata University Graduate School of Medical and Dental Sciences, 2 5274 Gakkocho dori, Niigata City, Niigata 951 8514, Japan
    J Cell Sci 120:2565-73. 2007
    ..This study provides the first line of evidence that PIASxbeta is indispensable for osteoblast differentiation and matrix mineralization, and that this signaling molecule is located between Runx2 and osterix...
  6. pmc Chondromodulin-1 directly suppresses growth of human cancer cells
    Hisashi Mera
    Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    BMC Cancer 9:166. 2009
    ..In the present study, we sought to determine whether ChM1 has a direct action on tumor cells...
  7. doi request reprint Serum CA 125 expression as a tumor marker for diagnosis and monitoring the clinical course of epithelioid sarcoma
    Makiko Hoshino
    Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 Asahimachi dori, Chuo Ku, Niigata, 951 8510, Japan
    J Cancer Res Clin Oncol 136:457-64. 2010
    ....
  8. pmc Homeobox protein MSX2 acts as a molecular defense mechanism for preventing ossification in ligament fibroblasts
    Tatsuya Yoshizawa
    Divisions of Cell Biology and Molecular Pharmacology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Mol Cell Biol 24:3460-72. 2004
    ..Our findings indicate that Msx2 plays a central role in preventing ligaments and tendons from mineralizing...
  9. ncbi request reprint Activating Gs a mutation rarely occurs in musculoskeletal tumors other than fibrous dysplasia
    Wenguang Gu
    Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, 951 8510, Japan
    Anticancer Res 26:1611-4. 2006
    ..The development of secondary sarcoma in FD is a rare but well-established phenomenon. This finding raised the possibility that a common gene mutation exists in these tumors...
  10. ncbi request reprint Frequent absence of tumor suppressor FUS1 protein expression in human bone and soft tissue sarcomas
    Guidong Li
    Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Niigata, Japan
    Anticancer Res 31:11-21. 2011
    ..3. Frequent loss of FUS1 protein expression is associated with lung cancer development. This study examined FUS1 expression and its possible tumor-suppressive role in bone and soft tissue sarcomas...
  11. doi request reprint Expression of podoplanin in human bone and bone tumors: New marker of osteogenic and chondrogenic bone tumors
    Takashi Ariizumi
    Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, 757 1, Asahimachi Dori, Niigata City, Niigata 951 8510, Japan
    Pathol Int 60:193-202. 2010
    ..Therefore, podoplanin may be a sensitive immunohistochemical marker of osteogenic and chondrogenic bone tumors...
  12. doi request reprint High-level expression of podoplanin in benign and malignant soft tissue tumors: immunohistochemical and quantitative real-time RT-PCR analysis
    Yongjun Xu
    Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata University Medical and Dental Hospital, 757 1, Asahimachi Dori, Niigata City, Niigata Prefecture 951 8510, Japan
    Oncol Rep 25:599-607. 2011
    ....
  13. ncbi request reprint Histological assessment in grafts of highly purified beta-tricalcium phosphate (OSferion) in human bones
    Akira Ogose
    Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1 751, Niigata 951 8510, Japan
    Biomaterials 27:1542-9. 2006
    ..Silver impregnation revealed the presence of collagen fibrils within probable micropores of OSferion...
  14. ncbi request reprint Establishment and characterization of a novel myxofibrosarcoma cell line
    Hiroyuki Kawashima
    Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 Asahimachi dori, Niigata 951 8510, Japan
    Cancer Genet Cytogenet 161:28-35. 2005
    ..In this system, the human-specific Alu sequence and the mouse L1 sequence were used as specific cell markers of identity. In situ hybridization revealed neoplastic proliferation of the multinucleated giant cells of human origin...
  15. ncbi request reprint Sclerosing epithelioid fibrosarcoma with der(10)t(10;17)(p11;q11)
    Akira Ogose
    Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1 751, Niigata 951 8510, Japan
    Cancer Genet Cytogenet 152:136-40. 2004
    ..The karyotype of the tumor exhibited der(1)t(1;10)(p31;p11), der(10)t(10;17)(p11;q11), and der(17) t(11;17)(?;q11). Rearrangement of 10p11 was also found in one previous reported case of this uncommon tumor...
  16. ncbi request reprint Expression of bone morphogenetic proteins in giant cell tumor of bone
    Naoko Kudo
    Division of Orthopedic Surgery, Department of Regenerative Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Niigata 951 8510, Japan
    Anticancer Res 29:2219-25. 2009
    ..Although the bone formation in GCT in supposedly due to bone morphogenetic proteins (BMPs), the expression pattern of BMPs in GCT has not been well investigated...
  17. doi request reprint Establishment and characterization of a novel dedifferentiated liposarcoma cell line, NDDLS-1
    Takashi Ariizumi
    Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Niigata, Japan
    Pathol Int 61:461-8. 2011
    ..The NDDLS-1 cell line is consistent with the parental dedifferentiated liposarcoma, and it should therefore be useful for further investigations of human dedifferentiated liposarcomas...
  18. pmc Multinucleation followed by an acytokinetic cell division in myxofibrosarcoma with giant cell proliferation
    Takashi Ariizumi
    Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Exp Clin Cancer Res 28:44. 2009
    ..Myxofibrosarcoma consists of spindled and pleomorphic tumor cells and bizarre multinucleated giant cells. Some of these multinucleated cells are considered to be neoplastic...
  19. ncbi request reprint Diagnosis of peripheral nerve sheath tumors around the pelvis
    Akira Ogose
    Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951 8510, Japan
    Jpn J Clin Oncol 34:405-13. 2004
    ..To distinguish between benign and malignant peripheral nerve sheath tumors around the pelvis...
  20. doi request reprint Efficient virotherapy for osteosarcoma by telomerase-specific oncolytic adenovirus
    Guidong Li
    Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
    J Cancer Res Clin Oncol 137:1037-51. 2011
    ..A telomerase-specific oncolytic adenovirus, Telomelysin, can selectively kill cancer cells, and be attenuated in normal cells. We herein describe the oncolytic effect of Telomelysin on human osteosarcoma both in vitro and in vivo...
  21. ncbi request reprint High-level expression of the coxsackievirus and adenovirus receptor messenger RNA in osteosarcoma, Ewing's sarcoma, and benign neurogenic tumors among musculoskeletal tumors
    Wenguang Gu
    Divisions of Orthopedic Surgery and Cell Biology and Molecular Pharmacology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Clin Cancer Res 10:3831-8. 2004
    ..CAR has been shown to function as the primary receptor for adenoviruses and to play a critical role in adenovirus entry into host cells. It is important for clinical gene therapy to determine the expression level of CAR in tumor tissues...
  22. doi request reprint Cytogenetic and real-time quantitative reverse-transcriptase polymerase chain reaction analyses in pleomorphic rhabdomyosarcoma
    Guidong Li
    Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University Hospital, Niigata, Japan
    Cancer Genet Cytogenet 192:1-9. 2009
    ..Our findings suggest that the detections of MyoD1 and myogenin transcripts using real-time quantitative RT-PCR, combined with immunohistochemical stains, are extremely sensitive and useful for the diagnosis of PRMS...
  23. ncbi request reprint Malignant solitary fibrous tumor of the soft tissue: a cytogenetic study
    Makiko Hoshino
    Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University Hospital, Asahimachi 1 751, Niigata 951 8510, Japan
    Cancer Genet Cytogenet 177:55-8. 2007
    ..Its karyotype was: 70,XXX,+X[4],+1[2],add(1)(p36)[4],add(1)[2],+2[4],-3[4],+6[4],add(6)(p11)x2[4],+7[4],+9[3],-11[4],-12[4],-13[4],add(13)(p11)x2[4],-14[4],+15[4],-16[3],-17[4],-19[4],+20,[4],+21[4],+22[2],+mar1x2[4][cp4]...
  24. doi request reprint Molecular analyses of cell origin and detection of circulating tumor cells in the peripheral blood in alveolar soft part sarcoma
    Makiko Hoshino
    Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1 751, Niigata 951 8510, Japan
    Cancer Genet Cytogenet 190:75-80. 2009
    ..The findings suggest that ASPS is not of skeletal muscle origin. ASPS tumor cells in the peripheral blood could be monitored by RT-PCR...
  25. ncbi request reprint Activating Gs alpha mutation at the Arg201 codon in liposclerosing myxofibrous tumor
    Atsushi Matsuba
    Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Japan
    Hum Pathol 34:1204-9. 2003
    ..This result strongly suggests that a subset of LSMFT is a variant form of FD...
  26. ncbi request reprint Cystic teratoma of the diaphragm which mimicked soft tissue lipoma
    Takashi Ariizumi
    Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Niigata, 951 8510, Japan
    Skeletal Radiol 36:991-4. 2007
    ..We performed marginal excision. The tumor contained a large number of hairs and oily liquid; and it was connected to the diaphragm...
  27. ncbi request reprint Alveolar soft part sarcoma in Japan: multi-institutional study of 57 patients from the Japanese Musculoskeletal Oncology Group
    Akira Ogose
    Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Oncology 65:7-13. 2003
    ..The efficacy of chemotherapy for soft tissue sarcoma, including high-dose ifosfamide and cisplatin, has not been established yet. Some reports suggest ASPS may occur primarily in bone...
  28. ncbi request reprint Effect of dexamethasone on growth inhibition and chondrogenic maturation of human chondrosarcoma
    Hiroyuki Kawashima
    Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 Asahimachi dori, Niigata 951 8510, Japan
    J Orthop Sci 8:341-5. 2003
    ..These results suggest that dexamethasone caused growth inhibition and induced chondrogenic maturation of human chondrosarcoma cells...
  29. doi request reprint Telomelysin shows potent antitumor activity through apoptotic and non-apoptotic cell death in soft tissue sarcoma cells
    Gui Dong Li
    Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan Department of Orthopedic Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
    Cancer Sci 104:1178-88. 2013
    ....
  30. ncbi request reprint Histological examination of beta-tricalcium phosphate graft in human femur
    Akira Ogose
    Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Course for Biological Functions and Medical Control, Graduate School of Medical and Dental Science, Niigata University, Niigata, Japan
    J Biomed Mater Res 63:601-4. 2002
    ..There was a considerable number of osteoclast-like giant cells surrounding the beta-TCP. This case illustrated that highly purified beta-TCP had prominent osteoconductive activity and biodegradable nature in human bone...
  31. ncbi request reprint Plexiform schwannoma of the forearm
    Keiichi Katsumi
    Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1 751, 951 8510 Niigata, Japan
    Skeletal Radiol 32:719-23. 2003
    ..Pre-operative diagnosis of the rare plexiform schwannoma may be possible with careful imaging examination for the target sign...
  32. ncbi request reprint Comparison of hydroxyapatite and beta tricalcium phosphate as bone substitutes after excision of bone tumors
    Akira Ogose
    Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951 8510, Japan
    J Biomed Mater Res B Appl Biomater 72:94-101. 2005
    ..7 weeks in beta-TCP. Highly purified beta-TCP appears to be advantageous relative to HA for surgical intervention in bone tumors consequent to the nature of remodeling and superior osteoconductivity...
  33. ncbi request reprint Conditions suggesting lymphoma: case 3. Primary synovial lymphoma with osteoclast-like giant cells presenting as a tenosynovial giant-cell tumor
    Akira Ogose
    Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    J Clin Oncol 23:3847-8. 2005
  34. ncbi request reprint Presacral multiple cellular schwannomas
    Akira Ogose
    Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Course for Biological Functions and Medical Control, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Spine (Phila Pa 1976) 28:E426-9. 2003
    ..Case report. The authors documented a patient presenting with multiple cellular schwannomas along the sciatic nerve. The patient had no stigmas of neurofibromatosis. Thirteen tumors were resected via both anterior and posterior approaches...
  35. ncbi request reprint Tensile stress induces alpha-adaptin C production in mouse calvariae in an organ culture: possible involvement of endocytosis in mechanical stress-stimulated osteoblast differentiation
    Junko Shimomura
    Division of Cell Biology and Molecular Pharmacology, Niigata University Graduate School of Medical and Dental Sciences, Gakkocho dori, Japan
    J Cell Physiol 195:488-96. 2003
    ..These results, taken together, suggest that TS accelerates osteoblast differentiation and osteogenesis, possibly through the induction of the alpha-adaptin C expression and consequent activation of receptor-mediated endocytosis...
  36. ncbi request reprint Ischial weight-bearing brace after the infection of megaprosthesis a salvage method for resection arthroplasty
    Akira Ogose
    Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Japan
    J Arthroplasty 20:954-6. 2005
    ..The patient can walk alone with an ischial weight-bearing brace. Removal of the endoprosthesis and application of ischial weight-bearing brace may be a possible option for the treatment of infected megaprosthesis...
  37. ncbi request reprint Expression of osteopontin in cisplatin-induced tubular injury
    Seitaro Iguchi
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Nephron Exp Nephrol 97:e96-105. 2004
    ....
  38. ncbi request reprint A cell line with characteristics of the periodontal ligament fibroblasts is negatively regulated for mineralization and Runx2/Cbfa1/Osf2 activity, part of which can be overcome by bone morphogenetic protein-2
    Yoshinori Saito
    Divisions of Cell Biology and Molecular Pharmacology, Niigata University Graduate School of Medical and Dental Sciences, 5274 2 Bancho, Gakkocho dori, Niigata City, Niigata 951 8514, Japan
    J Cell Sci 115:4191-200. 2002
    ..Furthermore, PDL-L2 cells appeared to have a regulatory mechanism by which the function of Runx2 is normally suppressed...
  39. ncbi request reprint A painful large ganglion cyst of the ankle treated by the injection of OK-432
    Akira Ogose
    Division of Orthopedic Surgery, Graduate School of Medical and Dental Science, Niigata University, 1 751 Asahimachi, Niigata, 951 8510, Japan
    Mod Rheumatol 17:341-3. 2007
    ..OK-432 injection seems to be a safe, convenient, and effective alternative to surgical treatment for either symptomatic or recurrent ganglia...