Research Topics
Genomes and Genes | Hiroyuki KawashimaSummaryAffiliation: Niigata University Country: Japan Publications
| Collaborators
|
Detail Information
Publications
Successful surgical treatment of angiosarcoma of the spine: a case reportHiroyuki Kawashima
Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, Japan
Spine (Phila Pa 1976) 29:E280-3. 2004..Case report...- Expression of the coxsackievirus and adenovirus receptor in musculoskeletal tumors and mesenchymal tissues: efficacy of adenoviral gene therapy for osteosarcomaHiroyuki Kawashima
Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 Asahimachi dori, Niigata 951 8510
Cancer Sci 94:70-5. 2003..Most osteosarcomas appeared to express high levels of CAR, and thus adenovirus-mediated p53 gene therapy is likely to be suitable for the treatment of such tumors... - Ossifying fibromyxoid tumor of soft parts with clonal chromosomal aberrationsHiroyuki Kawashima
Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510 Japan
Cancer Genet Cytogenet 176:156-60. 2007..Combined with several previously reported studies, these aberrations could not identify a common cytogenetic abnormality in OFMT... - Establishment of novel human dedifferentiated chondrosarcoma cell line with osteoblastic differentiationNaoko Kudo
Division of Orthopaedic Surgery, Department of Regenerative Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, 757 1 Asahimachi dori Ichiban cho, Niigata City, Niigata, 951 8510, Japan
Virchows Arch 451:691-9. 2007..To our knowledge, this is the first report of the establishment of a human dedifferentiated chondrosarcoma... - PIASxbeta is a key regulator of osterix transcriptional activity and matrix mineralization in osteoblastsMd Moksed Ali
Division of Cell Biology and Molecular Pharmacology, Niigata University Graduate School of Medical and Dental Sciences, 2 5274 Gakkocho dori, Niigata City, Niigata 951 8514, Japan
J Cell Sci 120:2565-73. 2007..This study provides the first line of evidence that PIASxbeta is indispensable for osteoblast differentiation and matrix mineralization, and that this signaling molecule is located between Runx2 and osterix... 
Chondromodulin-1 directly suppresses growth of human cancer cellsHisashi Mera
Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
BMC Cancer 9:166. 2009..In the present study, we sought to determine whether ChM1 has a direct action on tumor cells...
Serum CA 125 expression as a tumor marker for diagnosis and monitoring the clinical course of epithelioid sarcomaMakiko Hoshino
Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 Asahimachi dori, Chuo Ku, Niigata, 951 8510, Japan
J Cancer Res Clin Oncol 136:457-64. 2010....- Homeobox protein MSX2 acts as a molecular defense mechanism for preventing ossification in ligament fibroblastsTatsuya Yoshizawa
Divisions of Cell Biology and Molecular Pharmacology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Mol Cell Biol 24:3460-72. 2004..Our findings indicate that Msx2 plays a central role in preventing ligaments and tendons from mineralizing... - Expression of podoplanin in human bone and bone tumors: New marker of osteogenic and chondrogenic bone tumorsTakashi Ariizumi
Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, 757 1, Asahimachi Dori, Niigata City, Niigata 951 8510, Japan
Pathol Int 60:193-202. 2010..Therefore, podoplanin may be a sensitive immunohistochemical marker of osteogenic and chondrogenic bone tumors... - Frequent absence of tumor suppressor FUS1 protein expression in human bone and soft tissue sarcomasGuidong Li
Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Niigata, Japan
Anticancer Res 31:11-21. 2011..3. Frequent loss of FUS1 protein expression is associated with lung cancer development. This study examined FUS1 expression and its possible tumor-suppressive role in bone and soft tissue sarcomas... - Activating Gs a mutation rarely occurs in musculoskeletal tumors other than fibrous dysplasiaWenguang Gu
Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, 951-8510, Japan
Anticancer Res 26:1611-4. 2006..CONCLUSION: Activating Gs a mutation rarely occurs in musculoskeletal tumors other than FD. The occurrence of most sarcomas displays no correlation with Gs a mutations... - High-level expression of podoplanin in benign and malignant soft tissue tumors: immunohistochemical and quantitative real-time RT-PCR analysisYongjun Xu
Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata University Medical and Dental Hospital, 757 1, Asahimachi Dori, Niigata City, Niigata Prefecture 951 8510, Japan
Oncol Rep 25:599-607. 2011.... - Histological assessment in grafts of highly purified beta-tricalcium phosphate (OSferion) in human bonesAkira Ogose
Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1 751, Niigata 951 8510, Japan
Biomaterials 27:1542-9. 2006..Silver impregnation revealed the presence of collagen fibrils within probable micropores of OSferion... - Expression of bone morphogenetic proteins in giant cell tumor of boneNaoko Kudo
Division of Orthopedic Surgery, Department of Regenerative Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Niigata 951 8510, Japan
Anticancer Res 29:2219-25. 2009..Although the bone formation in GCT in supposedly due to bone morphogenetic proteins (BMPs), the expression pattern of BMPs in GCT has not been well investigated... - Sclerosing epithelioid fibrosarcoma with der(10)t(10;17)(p11;q11)Akira Ogose
Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1 751, Niigata 951 8510, Japan
Cancer Genet Cytogenet 152:136-40. 2004..The karyotype of the tumor exhibited der(1)t(1;10)(p31;p11), der(10)t(10;17)(p11;q11), and der(17) t(11;17)(?;q11). Rearrangement of 10p11 was also found in one previous reported case of this uncommon tumor... - Establishment and characterization of a novel myxofibrosarcoma cell lineHiroyuki Kawashima
Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 Asahimachi dori, Niigata 951 8510, Japan
Cancer Genet Cytogenet 161:28-35. 2005..In this system, the human-specific Alu sequence and the mouse L1 sequence were used as specific cell markers of identity. In situ hybridization revealed neoplastic proliferation of the multinucleated giant cells of human origin... - Establishment and characterization of a novel dedifferentiated liposarcoma cell line, NDDLS-1Takashi Ariizumi
Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Niigata, Japan
Pathol Int 61:461-8. 2011..The NDDLS-1 cell line is consistent with the parental dedifferentiated liposarcoma, and it should therefore be useful for further investigations of human dedifferentiated liposarcomas... - Multinucleation followed by an acytokinetic cell division in myxofibrosarcoma with giant cell proliferationTakashi Ariizumi
Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
J Exp Clin Cancer Res 28:44. 2009..Myxofibrosarcoma consists of spindled and pleomorphic tumor cells and bizarre multinucleated giant cells. Some of these multinucleated cells are considered to be neoplastic... - Diagnosis of peripheral nerve sheath tumors around the pelvisAkira Ogose
Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951 8510, Japan
Jpn J Clin Oncol 34:405-13. 2004..To distinguish between benign and malignant peripheral nerve sheath tumors around the pelvis... - Efficient virotherapy for osteosarcoma by telomerase-specific oncolytic adenovirusGuidong Li
Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, 1 757 Asahimachi dori, Chuo Ku, Niigata 951 8510, Japan
J Cancer Res Clin Oncol 137:1037-51. 2011..A telomerase-specific oncolytic adenovirus, Telomelysin, can selectively kill cancer cells, and be attenuated in normal cells. We herein describe the oncolytic effect of Telomelysin on human osteosarcoma both in vitro and in vivo... - High-level expression of the coxsackievirus and adenovirus receptor messenger RNA in osteosarcoma, Ewing's sarcoma, and benign neurogenic tumors among musculoskeletal tumorsWenguang Gu
Divisions of Orthopedic Surgery and Cell Biology and Molecular Pharmacology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Clin Cancer Res 10:3831-8. 2004..CAR has been shown to function as the primary receptor for adenoviruses and to play a critical role in adenovirus entry into host cells. It is important for clinical gene therapy to determine the expression level of CAR in tumor tissues... - Cytogenetic and real-time quantitative reverse-transcriptase polymerase chain reaction analyses in pleomorphic rhabdomyosarcomaGuidong Li
Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University Hospital, Niigata, Japan
Cancer Genet Cytogenet 192:1-9. 2009..Our findings suggest that the detections of MyoD1 and myogenin transcripts using real-time quantitative RT-PCR, combined with immunohistochemical stains, are extremely sensitive and useful for the diagnosis of PRMS... - Activating Gs alpha mutation at the Arg201 codon in liposclerosing myxofibrous tumorAtsushi Matsuba
Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Japan
Hum Pathol 34:1204-9. 2003..This result strongly suggests that a subset of LSMFT is a variant form of FD... - Malignant solitary fibrous tumor of the soft tissue: a cytogenetic studyMakiko Hoshino
Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University Hospital, Asahimachi 1 751, Niigata 951 8510, Japan
Cancer Genet Cytogenet 177:55-8. 2007..Its karyotype was: 70,XXX,+X[4],+1[2],add(1)(p36)[4],add(1)[2],+2[4],-3[4],+6[4],add(6)(p11)x2[4],+7[4],+9[3],-11[4],-12[4],-13[4],add(13)(p11)x2[4],-14[4],+15[4],-16[3],-17[4],-19[4],+20,[4],+21[4],+22[2],+mar1x2[4][cp4]... - Molecular analyses of cell origin and detection of circulating tumor cells in the peripheral blood in alveolar soft part sarcomaMakiko Hoshino
Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1 751, Niigata 951 8510, Japan
Cancer Genet Cytogenet 190:75-80. 2009..The findings suggest that ASPS is not of skeletal muscle origin. ASPS tumor cells in the peripheral blood could be monitored by RT-PCR... - Cystic teratoma of the diaphragm which mimicked soft tissue lipomaTakashi Ariizumi
Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Niigata, 951 8510, Japan
Skeletal Radiol 36:991-4. 2007..We performed marginal excision. The tumor contained a large number of hairs and oily liquid; and it was connected to the diaphragm... - Alveolar soft part sarcoma in Japan: multi-institutional study of 57 patients from the Japanese Musculoskeletal Oncology GroupAkira Ogose
Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
Oncology 65:7-13. 2003..The efficacy of chemotherapy for soft tissue sarcoma, including high-dose ifosfamide and cisplatin, has not been established yet. Some reports suggest ASPS may occur primarily in bone... - Effect of dexamethasone on growth inhibition and chondrogenic maturation of human chondrosarcomaHiroyuki Kawashima
Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 Asahimachi-dori, Niigata 951-8510, Japan
J Orthop Sci 8:341-5. 2003..These results suggest that dexamethasone caused growth inhibition and induced chondrogenic maturation of human chondrosarcoma cells... - Histological examination of beta-tricalcium phosphate graft in human femurAkira Ogose
Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Course for Biological Functions and Medical Control, Graduate School of Medical and Dental Science, Niigata University, Niigata, Japan
J Biomed Mater Res 63:601-4. 2002..There was a considerable number of osteoclast-like giant cells surrounding the beta-TCP. This case illustrated that highly purified beta-TCP had prominent osteoconductive activity and biodegradable nature in human bone... - Plexiform schwannoma of the forearmKeiichi Katsumi
Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1-751, 951-8510 Niigata, Japan
Skeletal Radiol 32:719-23. 2003..Pre-operative diagnosis of the rare plexiform schwannoma may be possible with careful imaging examination for the target sign... - Comparison of hydroxyapatite and beta tricalcium phosphate as bone substitutes after excision of bone tumorsAkira Ogose
Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951 8510, Japan
J Biomed Mater Res B Appl Biomater 72:94-101. 2005..7 weeks in beta-TCP. Highly purified beta-TCP appears to be advantageous relative to HA for surgical intervention in bone tumors consequent to the nature of remodeling and superior osteoconductivity... - Conditions suggesting lymphoma: case 3. Primary synovial lymphoma with osteoclast-like giant cells presenting as a tenosynovial giant-cell tumorAkira Ogose
Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
J Clin Oncol 23:3847-8. 2005 - Presacral multiple cellular schwannomasAkira Ogose
Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Course for Biological Functions and Medical Control, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
Spine (Phila Pa 1976) 28:E426-9. 2003..Case report. The authors documented a patient presenting with multiple cellular schwannomas along the sciatic nerve. The patient had no stigmas of neurofibromatosis. Thirteen tumors were resected via both anterior and posterior approaches... - Tensile stress induces alpha-adaptin C production in mouse calvariae in an organ culture: possible involvement of endocytosis in mechanical stress-stimulated osteoblast differentiationJunko Shimomura
Division of Cell Biology and Molecular Pharmacology, Niigata University Graduate School of Medical and Dental Sciences, Gakkocho dori, Japan
J Cell Physiol 195:488-96. 2003..These results, taken together, suggest that TS accelerates osteoblast differentiation and osteogenesis, possibly through the induction of the alpha-adaptin C expression and consequent activation of receptor-mediated endocytosis... - Ischial weight-bearing brace after the infection of megaprosthesis a salvage method for resection arthroplastyAkira Ogose
Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Japan
J Arthroplasty 20:954-6. 2005..The patient can walk alone with an ischial weight-bearing brace. Removal of the endoprosthesis and application of ischial weight-bearing brace may be a possible option for the treatment of infected megaprosthesis... - Expression of osteopontin in cisplatin-induced tubular injurySeitaro Iguchi
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Nephron Exp Nephrol 97:e96-105. 2004.... - A cell line with characteristics of the periodontal ligament fibroblasts is negatively regulated for mineralization and Runx2/Cbfa1/Osf2 activity, part of which can be overcome by bone morphogenetic protein-2Yoshinori Saito
Divisions of Cell Biology and Molecular Pharmacology, Niigata University Graduate School of Medical and Dental Sciences, 5274 2-Bancho, Gakkocho-dori, Niigata-city, Niigata 951-8514, Japan
J Cell Sci 115:4191-200. 2002..Furthermore, PDL-L2 cells appeared to have a regulatory mechanism by which the function of Runx2 is normally suppressed... - A painful large ganglion cyst of the ankle treated by the injection of OK-432Akira Ogose
Division of Orthopedic Surgery, Graduate School of Medical and Dental Science, Niigata University, 1 751 Asahimachi, Niigata, 951 8510, Japan
Mod Rheumatol 17:341-3. 2007..OK-432 injection seems to be a safe, convenient, and effective alternative to surgical treatment for either symptomatic or recurrent ganglia...