H Kawachi

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. ncbi Curcumin ameliorates macrophage infiltration by inhibiting NF-κB activation and proinflammatory cytokines in streptozotocin induced-diabetic nephropathy
    Vivian Soetikno
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    Nutr Metab (Lond) 8:35. 2011
  2. ncbi Therapeutic targets in the podocyte: findings in anti-slit diaphragm antibody-induced nephropathy
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Nephrol 22:450-6. 2009
  3. ncbi Slit diaphragm dysfunction in proteinuric states: identification of novel therapeutic targets for nephrotic syndrome
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Clin Exp Nephrol 13:275-80. 2009
  4. ncbi mAb 5-1-6 nephropathy and nephrin
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Faculty of Medicine, Niigata University, Niigata 951 8510 Japan
    Microsc Res Tech 57:236-40. 2002
  5. ncbi Cloning of rat homologue of podocin: expression in proteinuric states and in developing glomeruli
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Am Soc Nephrol 14:46-56. 2003
  6. ncbi Role of podocyte slit diaphragm as a filtration barrier
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Nephrology (Carlton) 11:274-81. 2006
  7. ncbi Cloning of rat nephrin: expression in developing glomeruli and in proteinuric states
    H Kawachi
    Department of Cell Biology and Department of Pathology, Institute of Nephrology, Niigata University School of Medicine, Japan
    Kidney Int 57:1949-61. 2000
  8. ncbi Crescent-forming mechanism in an irreversible Thy-1 model in rats
    A Oyanagi
    Department of Cell Biology, Institute of Nephrology, Niigata University School of Medicine, Niigata, Japan
    Nephron 89:439-47. 2001
  9. ncbi FAT is a component of glomerular slit diaphragms
    T Inoue
    Department of Renal Pathology, Institute of Nephrology, Faculty of Medicine, Niigata University, Niigata, Japan
    Kidney Int 59:1003-12. 2001
  10. ncbi Synaptic vesicle protein 2B is expressed in podocyte, and its expression is altered in proteinuric glomeruli
    Naoko Miyauchi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata 951-8510, Japan
    J Am Soc Nephrol 17:2748-59. 2006

Collaborators

Detail Information

Publications87

  1. ncbi Curcumin ameliorates macrophage infiltration by inhibiting NF-κB activation and proinflammatory cytokines in streptozotocin induced-diabetic nephropathy
    Vivian Soetikno
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    Nutr Metab (Lond) 8:35. 2011
    ..We hypothesized that the plant polyphenolic compound curcumin, which is known to exert potent anti-inflammatory effect, would ameliorate macrophage infiltration in streptozotocin (STZ)-induced diabetic rats...
  2. ncbi Therapeutic targets in the podocyte: findings in anti-slit diaphragm antibody-induced nephropathy
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Nephrol 22:450-6. 2009
    ..In vivo and in vitro studies demonstrated that angiotensin II type 2 receptor-mediated action enhanced the expression of nephrin. We propose that these molecules could be novel therapeutic targets for proteinuria...
  3. ncbi Slit diaphragm dysfunction in proteinuric states: identification of novel therapeutic targets for nephrotic syndrome
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Clin Exp Nephrol 13:275-80. 2009
    ..By the subtraction hybridization techniques using glomerular cDNA of normal and proteinuric rats, we detected that synaptic vesicle protein 2B and ephrin B1 are involved in the maintenance of the barrier function of the slit diaphragm...
  4. ncbi mAb 5-1-6 nephropathy and nephrin
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Faculty of Medicine, Niigata University, Niigata 951 8510 Japan
    Microsc Res Tech 57:236-40. 2002
    ..To better understand the structure of the slit diaphragm, it is particularly important to identify other components that build up the structure of the slit diaphragm together with nephrin...
  5. ncbi Cloning of rat homologue of podocin: expression in proteinuric states and in developing glomeruli
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Am Soc Nephrol 14:46-56. 2003
    ..It is postulated that podocin is one of the critical components of a slit diaphragm for maintaining the barrier function of the glomerular capillary wall...
  6. ncbi Role of podocyte slit diaphragm as a filtration barrier
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Nephrology (Carlton) 11:274-81. 2006
    ..These observations suggested that alteration of the molecular arrangement in the slit diaphragm is involved in the development of proteinuria in several kinds of glomerular diseases...
  7. ncbi Cloning of rat nephrin: expression in developing glomeruli and in proteinuric states
    H Kawachi
    Department of Cell Biology and Department of Pathology, Institute of Nephrology, Niigata University School of Medicine, Japan
    Kidney Int 57:1949-61. 2000
    ..Nephrin is identified as a product of the gene mutated in a patient with congenital nephrotic syndrome of the Finnish type. However, its precise localization and function are not yet fully clarified...
  8. ncbi Crescent-forming mechanism in an irreversible Thy-1 model in rats
    A Oyanagi
    Department of Cell Biology, Institute of Nephrology, Niigata University School of Medicine, Niigata, Japan
    Nephron 89:439-47. 2001
    ....
  9. ncbi FAT is a component of glomerular slit diaphragms
    T Inoue
    Department of Renal Pathology, Institute of Nephrology, Faculty of Medicine, Niigata University, Niigata, Japan
    Kidney Int 59:1003-12. 2001
    ..CONCLUSION: The molecular structure of FAT and its colocalization with 5-1-6 antigen and ZO-1 indicate that FAT is a component of slit diaphragms...
  10. ncbi Synaptic vesicle protein 2B is expressed in podocyte, and its expression is altered in proteinuric glomeruli
    Naoko Miyauchi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata 951-8510, Japan
    J Am Soc Nephrol 17:2748-59. 2006
    ..These results suggest that SV2B is a functional molecule of podocyte, and SV2B may play a role in the expression and proper localization of CD2AP...
  11. ncbi Dissociation of NEPH1 from nephrin is involved in development of a rat model of focal segmental glomerulosclerosis
    Yasuhiro Otaki
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, 951 8510, Japan
    Am J Physiol Renal Physiol 295:F1376-87. 2008
    ..It is postulated that the dissociation of NEPH1 from nephrin initiates proteinuria and that the SD alteration restricted in these molecules plays a critical role in the development of sclerotic changes in FSGS...
  12. ncbi Ephrin-B1 localizes at the slit diaphragm of the glomerular podocyte
    T Hashimoto
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Kidney Int 72:954-64. 2007
    ..We suggest that ephrin-B1 has a role in maintaining barrier function at the slit diaphragm...
  13. ncbi Role of mesangial cell damage in progressive renal disease
    F Shimizu
    Department of Cell Biology, Institute of Nephrology, Niigata University School of Medicine, Asahimachi Dori, Niigata, Japan
    Kidney Blood Press Res 22:5-12. 1999
    ..1 molecule, are expected to provide new insights into mechanisms of irreversible renal injury initiated by mesangial cell damage and also to develop novel and rational therapeutic approaches to progressive, primarily mesangial diseases...
  14. ncbi Blocking angiotensin II ameliorates proteinuria and glomerular lesions in progressive mesangioproliferative glomerulonephritis
    T Nakamura
    Division of Blood Transfusion, Department of Internal Medicine, Niigata University School of Medicine, Niigata, Japan
    Kidney Int 55:877-89. 1999
    ....
  15. ncbi Nephrin and podocin dissociate at the onset of proteinuria in experimental membranous nephropathy
    Takeshi Nakatsue
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Kidney Int 67:2239-53. 2005
    ..The pathogenic mechanism of proteinuria in membranous nephropathy remains uncertain. This study was undertaken to analyze the pathogenic role of slit diaphragm in proteinuria in experimental membranous nephropathy...
  16. ncbi Podocyte injuries exacerbate mesangial proliferative glomerulonephritis
    Y Morioka
    Department of Cell Biology, Institute of Nephrology, Faculty of Medicine, Niigata University, Japan
    Kidney Int 60:2192-204. 2001
    ..The irreversible mesangial alterations caused by consecutive injections of PAN and mAb 1-22-3 may be a novel model that could be used to analyze the mechanism of progressive mesangial alteration...
  17. ncbi Expression of allograft inflammatory factor-1 in kidneys: A novel molecular component of podocyte
    Y Tsubata
    Department of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Kidney Int 70:1948-54. 2006
    ....
  18. ncbi An anti-CD5 monoclonal antibody ameliorates proteinuria and glomerular lesions in rat mesangioproliferative glomerulonephritis
    Y Ikezumi
    Department of Cell Biology, Institute of Nephrology, Niigata University School of Medicine, Japan
    Kidney Int 58:100-14. 2000
    ..In this study, we elucidated the role of lymphocytes in the development of mesangial proliferative GN...
  19. ncbi Glomerular CD8+ cells predict progression of childhood IgA nephropathy
    T Watanabe
    Department of Cell Biology, Institute of Nephrology, Faculty of Medicine, Niigata University, Japan
    Pediatr Nephrol 16:561-7. 2001
    ..In conclusion, these results indicate that the number of glomerular CD8+ cells is the most sensitive predictor of disease progression in childhood IgAN...
  20. ncbi Angiotensin II type 1 and type 2 receptors play opposite roles in regulating the barrier function of kidney glomerular capillary wall
    Koichi Suzuki
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, 951 8510, Japan
    Am J Pathol 170:1841-53. 2007
    ....
  21. ncbi FK506 ameliorates proteinuria and glomerular lesions induced by anti-Thy 1.1 monoclonal antibody 1-22-3
    Yohei Ikezumi
    Department of Cell Biology, Institute of Nephrology, and Department of Pediatrics, Faculty of Medicine, Niigata University, Niigata, Japan
    Kidney Int 61:1339-50. 2002
    ..1.96 +/- 0.29, P < 0.01] on day 14. CONCLUSION: Th1 cytokines may play an important role in the development of mesangial proliferative glomerulonephritis, and could be targets for therapy. FK506 might be available for clinical use...
  22. ncbi [Novel functional molecules of slit membrane]
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences
    Nippon Rinsho 62:1823-8. 2004
    ..These studies indicated that the precise arrangement and the interaction of these molecules are essential for maintaining the barrier function of slit membrane...
  23. ncbi Decreased collagen-degrading activity could be a marker of prolonged mesangial matrix expansion
    Masayuki Tomita
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, 951-8510, Niigata, Japan
    Clin Exp Nephrol 8:17-26. 2004
    ..We aimed to elucidate the relative role of the matrix metalloproteinase (MMP)/tissue inhibitors of metalloproteinases (TIMPs) system in the development of prolonged mesangial matrix expansion...
  24. ncbi Monoclonal antibody against rat podocyte-derived macrophagic cells reacts with crescent-forming cells in an experimental model
    Michiaki Orikasa
    Department of Biomedical Technology, School of Health Science, Faculty of Medicine, Niigata University, Niigata, Japan
    Nephrology (Carlton) 8:217-23. 2003
    ..We propose a novel concept of crescent formation, suggesting that crescents may be partly composed of phenotypically changed cells, which could not be detected by typical markers for glomerular epithelial cells or monocytes/macrophages...
  25. ncbi Fractalkine expression and the recruitment of CX3CR1+ cells in the prolonged mesangial proliferative glomerulonephritis
    Yumi Ito
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Kidney Int 61:2044-57. 2002
    ..These expressions could be predictors of the prolonged disease of the mesangial proliferative glomerulonephritis...
  26. ncbi [Structure and function of podocyte]
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences
    Nippon Rinsho 64:70-3. 2006
  27. ncbi IFN-inducible protein-10 plays a pivotal role in maintaining slit-diaphragm function by regulating podocyte cell-cycle balance
    Gi Dong Han
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    J Am Soc Nephrol 17:442-53. 2006
    ..These results raise the possibility that IP-10 could become a novel therapeutic target in nephrotic syndrome and several diseases with altered cell-cycle balance...
  28. ncbi Multi-glycoside of Tripterygium wilfordii Hook f. ameliorates proteinuria and acute mesangial injury induced by anti-Thy1.1 monoclonal antibody
    Yigang Wan
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Nephron Exp Nephrol 99:e121-9. 2005
    ..1 GN most likely by reducing expression of injurious cytokines, indicating that GTW has suppressive effects on acute inflammatory changes in glomeruli...
  29. ncbi SM22alpha: the novel phenotype marker of injured glomerular epithelial cells in anti-glomerular basement membrane nephritis
    Asa Ogawa
    Division of Clinical Nephrology and Rheumatology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Nephron Exp Nephrol 106:e77-87. 2007
    ..SM22alpha is a 22-kDa cytoskeletal protein that is exclusively expressed in smooth muscle cells. We investigated the localization of SM22alpha at mRNA and protein levels, and its pathological significance in anti-GBM nephritis kidneys...
  30. ncbi Activated macrophages down-regulate podocyte nephrin and podocin expression via stress-activated protein kinases
    Yohei Ikezumi
    Department of Pediatrics, Niigata University Medical and Dental Hospital, 1 757 Asahimachi dori, Chuo Ku, Asahimachi Dori, Niigata 951 8510, Japan
    Biochem Biophys Res Commun 376:706-11. 2008
    ..This study demonstrates that activated macrophages can induce podocyte injury via a TNFalpha-JNK/p38-dependent mechanism. This may explain, in part, the protective effects of JNK and p38 blockade in experimental kidney disease...
  31. ncbi Attenuation of mouse acute colitis by naked hepatocyte growth factor gene transfer into the liver
    Takayasu Hanawa
    Department of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata City, Niigata 951-8510, Japan
    J Gene Med 8:623-35. 2006
    ..CONCLUSIONS: HGF gene transfer attenuated acute colitis by facilitating intestinal wound repair as well as inhibiting inflammation, suggesting a new strategy for treatment of IBD...
  32. ncbi Use of mizoribine as a rescue drug for steroid-resistant pediatric IgA nephropathy
    Yohei Ikezumi
    Department of Pediatrics, Niigata University Medical and Dental Hospital, Asahimachi Dori, Niigata, Japan
    Pediatr Nephrol 23:645-50. 2008
    ..The ability of Miz to reduce the number of activated macrophages may be an important mechanism by which this drug ameliorated renal disease in these patients...
  33. ncbi Altered expression of junctional adhesion molecule 4 in injured podocytes
    Yutaka Harita
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Am J Physiol Renal Physiol 290:F335-44. 2006
    ..JAM4 may have a different role at the apical membrane besides the role as a junctional molecule and is likely associated with the unique structure of this epithelium...
  34. ncbi The sialoadhesin (CD169) expressing a macrophage subset in human proliferative glomerulonephritis
    Yohei Ikezumi
    Division of Pediatrics, Niigata University Medical and Dental Hospital, Asahimachi Dori, Niigata 951 8510, Japan
    Nephrol Dial Transplant 20:2704-13. 2005
    ..The current study examined the significance of Sn+ macrophages in human proliferative glomerulonephritis...
  35. ncbi Kidney-targeted naked DNA transfer by retrograde renal vein injection in rats
    Hiroki Maruyama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8120, Japan
    Hum Gene Ther 13:455-68. 2002
    ..This novel technique is simple and safe, allowing high-level and long-term stable gene expression specific to the fibroblasts near the PTC, and should have therapeutic value for future applications in humans...
  36. ncbi Contrasting effects of steroids and mizoribine on macrophage activation and glomerular lesions in rat thy-1 mesangial proliferative glomerulonephritis
    Yohei Ikezumi
    Department of Pediatrics, Niigata University Medical and Dental Hospital, Japan
    Am J Nephrol 31:273-82. 2010
    ..In addition, clinical studies have suggested that the ability of mizoribine (MZR) to suppress steroid-resistant proliferative glomerulonephritis may operate via inhibiting pro-inflammatory macrophage activation...
  37. ncbi Histological differences in new-onset IgA nephropathy between children and adults
    Yohei Ikezumi
    Department of Pediatrics, Niigata University Medical and Dental Hospital, Asahimachi Dori, Niigata 951 8510, Japan
    Nephrol Dial Transplant 21:3466-74. 2006
    ..We addressed this question by comparing both histology and leucocyte accumulation in biopsies of recently diagnosed childhood and adult IgAN...
  38. ncbi Kinetic analysis of the development of pancreatic lesions in mice infected with a murine retrovirus
    Shiro Watanabe
    Department of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Clin Immunol 109:212-23. 2003
    ..Thus, MAIDS mice could be valuable for analyzing the pathogenesis of autoimmune-related pancreatitis associated with SjS...
  39. ncbi Genetic polymorphism of NPHS1 modifies the clinical manifestations of Ig A nephropathy
    Ichiei Narita
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi Dori, Niigata, Japan
    Lab Invest 83:1193-200. 2003
    ..This study suggests that the NPHS1 G349A polymorphism may be associated with heavy proteinuria and a decline in renal function in patients with IgAN...
  40. ncbi Effects of mineralocorticoid and angiotensin II receptor blockers on proteinuria and glomerular podocyte protein expression in a model of minimal change nephrotic syndrome
    Akihiro Fukuda
    Division of Circulatory and Body Fluid Regulation, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki, 889 1692, Japan
    Nephrology (Carlton) 15:321-6. 2010
    ..However, the effects of AR and/or MR blockers in a model of acute nephrotic syndrome remain unknown. The effects of AR and MR blockers were examined in puromycin aminonucleoside (PAN)-treated rats...
  41. ncbi Analysis of intestinal fibrosis in chronic colitis in mice induced by dextran sulfate sodium
    Kenji Suzuki
    Department of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata City, Niigata, Japan
    Pathol Int 61:228-38. 2011
    ..In conclusion, profibrogenic mesenchymal cells play an important role in the development of intestinal fibrosis in this chronic DSS-induced colitis model...
  42. ncbi IFN-inducible protein-10 has a differential role in podocyte during Thy 1.1 glomerulonephritis
    Gi Dong Han
    Department of Cell Biology, Institute of Nephrology, Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Am Soc Nephrol 14:3111-26. 2003
    ..Also, the findings suggested that anti-IP-10 treatment exacerbated the glomerular alterations in Thy1.1 GN by disturbing the podocyte function...
  43. ncbi Identification of alternatively activated macrophages in new-onset paediatric and adult immunoglobulin A nephropathy: potential role in mesangial matrix expansion
    Yohei Ikezumi
    Department of Pediatrics, Niigata University Medical and Dental Hospital, Niigata 951 8510 Japan
    Histopathology 58:198-210. 2011
    ..Therefore, the aim of this study was to investigate whether M2 macrophages are present in new-onset IgAN and if they are related to pathological differences between paediatric and adult disease...
  44. ncbi Blockade of interferon-gamma-inducible protein-10 attenuates chronic experimental colitis by blocking cellular trafficking and protecting intestinal epithelial cells
    Kenji Suzuki
    Department of Gastroenterology, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Pathol Int 57:413-20. 2007
    ....
  45. ncbi Rectal administration of tranilast ameliorated acute colitis in mice through increased expression of heme oxygenase-1
    Xiaomei Sun
    Department of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Pathol Int 60:93-101. 2010
    ..Tranilast might exert these effects partly through enhanced HO-1 expression in the colon, suggesting a potential adjunctive therapy for IBD...
  46. ncbi Molecular structure and function of the slit diaphragm: expression of nephrin in proteinuric states and in developing glomeruli
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Nephrol Dial Transplant 17:20-2. 2002
    ..With the interdigitation of foot processes, nephrin becomes concentrated in the slit pore, and finally restricted in the site of the slit diaphragm bridging two adjacent foot processes...
  47. ncbi Role of IP-10/CXCL10 in the progression of pancreatitis-like injury in mice after murine retroviral infection
    Yusuke Kawauchi
    Department of Gastroenterology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
    Am J Physiol Gastrointest Liver Physiol 291:G345-54. 2006
    ....
  48. ncbi Novel expression of sodium/myo-inositol co-transporter in podocytes in puromycin aminonucleoside nephrosis
    Yusuke Watanabe
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Niigata, 951-8510, Japan
    Nephrol Dial Transplant 19:817-22. 2004
    ..CONCLUSIONS: These findings suggest that SMIT expression in podocytes is not provoked by an effect of massive proteinuria but by extensive cellular injury...
  49. ncbi Blockade of CXCL10 protects mice from acute colitis and enhances crypt cell survival
    Shunya Sasaki
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Eur J Immunol 32:3197-205. 2002
    ..Thus, CXCL10 can be a new therapeutic target for inflammatory bowel disease by controlling the dynamics of epithelial homeostasis...
  50. ncbi The role of lymphocytes in the experimental progressive glomerulonephritis
    Yohei Ikezumi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Kidney Int 66:1036-48. 2004
    ..CONCLUSION: CD4+ T cells played a central role in the development of progressive glomerulonephritis, controlling recruitment and activation of CD8+ cytotoxic cells and/or macrophages...
  51. ncbi A notable case report of May-Hegglin anomaly with immune complex-related nephropathy: a genetic and histological analysis
    Y Ohtsuka
    Department of Pediatrics, Faculty of Medicine, Saga University, Saga City, Japan
    Clin Nephrol 75:255-62. 2011
    ..Moreover, the expression of nephrin and podocin, slit diagram protein, was normal. An inflammatory mechanism may occur separately from MYH9-related disease. This report presents a case of MHA with immune complex-related nephropathy...
  52. ncbi Hydrodynamics-based delivery of the viral interleukin-10 gene suppresses experimental crescentic glomerulonephritis in Wistar-Kyoto rats
    N Higuchi
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Gene Ther 10:1297-310. 2003
    ..These results demonstrate that pCAGGS-vIL-10 gene transfer by hydrodynamics-based transfection suppresses crescentic glomerulonephritis...
  53. ncbi Urinary sediment podocalyxin in children with glomerular diseases
    Katsue Kanno
    Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan
    Nephron Clin Pract 95:c91-9. 2003
    ..CONCLUSION: Quantification of urinary sediment podocalyxin by ELISA is a reliable and useful laboratory marker for the estimation of the severity of active glomerular injury and a urinary index of acute extracapillary changes...
  54. ncbi Neurexin-1, a presynaptic adhesion molecule, localizes at the slit diaphragm of the glomerular podocytes in kidneys
    Akira Saito
    Dept of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata, 951 8510, Japan
    Am J Physiol Regul Integr Comp Physiol 300:R340-8. 2011
    ..These observations suggest that neurexin is involved in the formation of the slit diaphragm and the maintenance of its function...
  55. ncbi Tumor suppressor carcinoembryonic antigen-related cell adhesion molecule 1 potentates the anchorage-independent growth of human hepatoma HepG2 cells
    Mariko Hokari
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi dori 1 757, Niigata 951 8510, Japan
    Life Sci 81:336-45. 2007
    ....
  56. ncbi Selective loss of podoplanin protein expression accompanies proteinuria and precedes alterations in podocyte morphology in a spontaneous proteinuric rat model
    Klaas Koop
    Department of Pathology, Leiden University Medical Center, Building 1, L1 Q, PO Box 9600, 2300 RC Leiden, The Netherlands
    Am J Pathol 173:315-26. 2008
    ..Our study suggests that decreased expression of podoplanin plays a role in the decrease of glomerular permselectivity...
  57. ncbi Suppressive activity of pemirolast potassium, an antiallergic drug, on glomerulonephritis. Studies in glomerulonephritis model rats and in patients with chronic glomerulonephritis concurrently affected by allergic rhinitis
    Tomohito Gohda
    Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Arzneimittelforschung 58:18-23. 2008
    ..Therefore, an alternative approach is greatly required. Pemirolast potassium (CAS 100299-08-9) is an antiallergic drug with high safety...
  58. ncbi Rosuvastatin is additive to high-dose candesartan in slowing progression of experimental mesangioproliferative glomerulosclerosis
    Stephanie Kramer
    Dept of Nephrology, Charite Universitatsmedizin Berlin, Campus Mitte, Humboldt Univ, Chariteplatz 1, D 10098 Berlin, Germany
    Am J Physiol Renal Physiol 294:F801-11. 2008
    ..The results suggest that rosuvastatin and an AT(1) blocker independently interfere with separate key pathways involved in the progression of chronic mesangioproliferative GS...
  59. ncbi Low-dose mTOR inhibition by rapamycin attenuates progression in anti-thy1-induced chronic glomerulosclerosis of the rat
    Stephanie Kramer
    Department of Nephrology and Center for Cardiovascular Research, Charite Universitatsmedizin Berlin, Charite Campus Mitte, Humboldt University, Berlin, Germany
    Am J Physiol Renal Physiol 294:F440-9. 2008
    ..e., proteinuria, extracellular matrix accumulation, renal cell proliferation, and inflammatory cell infiltration...
  60. ncbi [Function of the podocyte slit diaphragm]
    Hiroshi Kawachi
    Nippon Jinzo Gakkai Shi 49:77-81. 2007
  61. ncbi Blockade of IP-10/CXCR3 promotes progressive renal fibrosis
    Izaya Nakaya
    Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Nephron Exp Nephrol 107:e12-21. 2007
    ..However, the involvement of IP-10 in the pathogenesis of renal diseases via its receptor, CXCR3, remains unclear. To contribute to the clarification of this issue was the aim of this study...
  62. ncbi Modulation of nephrin in the diabetic kidney: association with systemic hypertension and increasing albuminuria
    Josephine M Forbes
    Department of Medicine and Endocrinology, University of Melbourne, Austin, Australia
    J Hypertens 20:985-92. 2002
    ..This study examines the possible relationship between nephrin expression and albuminuria in normotensive and hypertensive diabetic rats...
  63. ncbi Rat nephrin modulates cell morphology via the adaptor protein Nck
    Hongping Li
    Department of Medicine, McGill University, Montreal, Que, Canada
    Biochem Biophys Res Commun 349:310-6. 2006
    ..Taken together, we propose that Nck couples nephrin to the actin cytoskeleton in glomerular podocytes and contributes to the maintenance of normal morphology and function of podocytes...
  64. ncbi Mycophenolate mofetil slows progression in anti-thy1-induced chronic renal fibrosis but is not additive to a high dose of enalapril
    Stephanie Kramer
    Department of Nephrology, Charite University Medicine Berlin, Germany
    Am J Physiol Renal Physiol 289:F359-68. 2005
    ..The dual anti-inflammatory/anti-fibrotic intervention does not yield additive renoprotective effects, indicating that MMF and enalapril interfere with similar or very closely related pathways involved in progression of renal disease...
  65. ncbi SRC-family kinase Fyn phosphorylates the cytoplasmic domain of nephrin and modulates its interaction with podocin
    Hongping Li
    McGill University Health Centre, 3775 University Street, Room 236, Montreal, Quebec, Canada H3A 2B4
    J Am Soc Nephrol 15:3006-15. 2004
    ..In summary, Fyn phosphorylates the cytoplasmic domain of nephrin on tyrosine, leading to enhanced association with podocin and downstream signaling of nephrin...
  66. ncbi Prevention and reversal of renal injury by leptin in a new mouse model of diabetic nephropathy
    Takayoshi Suganami
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    FASEB J 19:127-9. 2005
    ..The model presented here will serve as a novel tool to analyze the molecular mechanism underlying not only the progression but also the regression of diabetic nephropathy...
  67. ncbi [Current topics. 1. Molecular mechanism involved in proteinuria]
    Hiroshi Kawachi
    Nippon Naika Gakkai Zasshi 93:954-9. 2004
  68. ncbi Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat
    Matthias Schaier
    Department of Nephrology, University Hospital, University of Heidelberg, Bergheimer Strasse 56a, 69115, Heidelberg, Germany
    J Mol Med (Berl) 82:116-25. 2004
    ..Receptor-specific retinoids may provide a novel therapeutic approach for the treatment of chronic glomerulonephritis...
  69. ncbi [Molecular mechanism responsible for the development of proteinuria: clinical significance of nephrin nephrotic syndrome]
    Fujio Shimizu
    Nippon Naika Gakkai Zasshi 92:1337-43. 2003
  70. ncbi Expression of podocyte-associated molecules in acquired human kidney diseases
    Klaas Koop
    Departments of Pathology and Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Soc Nephrol 14:2063-71. 2003
    ..This suggests that the alterations in the expression of podocyte-associated molecules represent a compensatory reaction of the podocyte that results from damage associated with proteinuria...
  71. ncbi Moderate alcohol intake has no impact on acute and chronic progressive anti-thy1 glomerulonephritis
    Harm Peters
    Division of Nephrology, Charite, Campus Mitte, Humboldt University, D 10098 Berlin, Germany
    Am J Physiol Renal Physiol 284:F1105-14. 2003
    ..The study suggests that, in contrast to cardiovascular disorders, moderate alcohol consumption might not provide specific protection in renal fibrotic disease...
  72. ncbi Disparate effects of angiotensin II antagonists and calcium channel blockers on albuminuria in experimental diabetes and hypertension: potential role of nephrin
    Belinda J Davis
    Department of Medicine, University of Melbourne, Repatriation Campus, Heidelberg West, Victoria 3081, Australia
    J Hypertens 21:209-16. 2003
    ....
  73. ncbi Therapeutic effect of sulphated hyaluronic acid, a potential selectin-blocking agent, on experimental progressive mesangial proliferative glomerulonephritis
    Mitsuhiro Matsuda
    Department of Medicine III, Okayama University Medical School, Japan
    J Pathol 198:407-14. 2002
    ..Sulphated oligosaccharides may be beneficial for the therapy of mesangial proliferative glomerulonephritis...
  74. ncbi Expression and regulation of adrenomedullin in renal glomerular podocytes
    Masayo Hino
    Department of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 330:178-85. 2005
    ..These results indicated that AM expression in the podocytes was upregulated by stimuli or condition relevant to podocyte injury, suggesting its potential role in podocyte pathophysiology...
  75. ncbi Spironolactone in combination with cilazapril ameliorates proteinuria and renal interstitial fibrosis in rats with anti-Thy-1 irreversible nephritis
    Masaki Asai
    Department of Internal Medicine, Keio University School of Medicine, Shinanomachi, Tokyo, Japan
    Hypertens Res 27:971-8. 2004
    ..These data suggest that concomitant treatment with spironolactone and an ACE inhibitor has beneficial effects on immune-initiated progressive kidney disease...
  76. ncbi Stimulation of soluble guanylate cyclase slows progression in anti-thy1-induced chronic glomerulosclerosis
    Yingrui Wang
    Department of Nephrology and Center of Cardiovascular Research, , , Humboldt University, Berlin, Germany
    Kidney Int 68:47-61. 2005
    ..The results suggest that soluble guanylate cyclase activation counteracts fibrosis and progression in chronic renal disease...
  77. ncbi Antagonism of PDGF-D by human antibody CR002 prevents renal scarring in experimental glomerulonephritis
    Tammo Ostendorf
    Division of Nephrology, University Hospital Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    J Am Soc Nephrol 17:1054-62. 2006
    ..In conclusion, these data provide evidence for a causal role of PDGF-D in the pathogenesis of renal scarring and point to a new therapeutic approach to progressive mesangioproliferative renal disease...
  78. ncbi Addition of the antioxidant probucol to angiotensin II type I receptor antagonist arrests progressive mesangioproliferative glomerulonephritis in the rat
    Shuji Kondo
    Department of Pediatrics, The Institute of Health Bioscience, The University of Tokushima Graduate School, Kuramoto-cho-3-chome, Tokushima 770-8503, Japan
    J Am Soc Nephrol 17:783-94. 2006
    ..The combination of probucol and candesartan may represent a novel route of therapy for patients with progressive GN...
  79. ncbi Pathophysiologic implications of reduced podocyte number in a rat model of progressive glomerular injury
    Daniela Macconi
    Mario Negri Institute for Pharmacological Research, Via Gavazzeni 11, 24125 Bergamo, Italy
    Am J Pathol 168:42-54. 2006
    ....
  80. ncbi Exogenous 5'-nucleotidase improves glomerular autoregulation in Thy-1 nephritic rats
    Tsuneo Takenaka
    Department of Nephrology, Saitama Medical College, Iruma Saitama 350-0495, Japan
    Am J Physiol Renal Physiol 290:F844-53. 2006
    ..Finally, our findings suggest that mesangial cells and/or 5'-nucleotidase plays an important role in mediating renal autoregulation...
  81. ncbi MAGI-1 is a component of the glomerular slit diaphragm that is tightly associated with nephrin
    Susumu Hirabayashi
    Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Lab Invest 85:1528-43. 2005
    ..MAGI-1 may play a role in determining the boundary between the apical and the bosolateral domain at the level of slit diaphragm...
  82. ncbi Continuous, noninvasive monitoring of local microscopic inflammation using a genetically engineered cell-based biosensor
    Yiman Meng
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan and Organ Transplantation Unit, 1st Affiliated Hospital, China Medical University, Shenyang, China
    Lab Invest 85:1429-39. 2005
    ..These results suggested that, without invasive procedures like tissue biopsies, continuous monitoring of microscopic inflammation is feasible in vivo via locally created, cell-based biosensors...
  83. ncbi Monoclonal antibody 1-22-3-induced glomerulonephritis in uninephrectomized rats as a model of progressive renal failure
    Masayuki Tomita
    Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co, Ltd, Osaka, Japan
    Nephrol Dial Transplant 20:2358-67. 2005
    ..In the current study, we examined the usefulness of anti-Thy-1 monoclonal antibody (mAb) 1-22-3-induced GN in uninephrectomized rats as a model of progressive renal failure by analysing the similarities to human disease...
  84. ncbi Enhancing cGMP in experimental progressive renal fibrosis: soluble guanylate cyclase stimulation vs. phosphodiesterase inhibition
    Yingrui Wang
    Dept. of Nephrology, Charit, Campus Mitte, Humboldt Univ, Schumannstrasse 20/21, D-10098 Berlin, Germany
    Am J Physiol Renal Physiol 290:F167-76. 2006
    ..The findings indicate that pharmacological enhancement of renal cGMP levels by sGC stimulation represents a novel and effective antifibrotic approach in progressive kidney disorders...
  85. ncbi Infusion of angiotensin II reduces loss of glomerular capillary area in the early phase of anti-Thy-1.1 nephritis possibly via regulating angiogenesis-associated factors
    Yuki Takazawa
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Kidney Int 68:704-22. 2005
    ....
  86. ncbi Role of p38 mitogen-activated protein kinase activation in podocyte injury and proteinuria in experimental nephrotic syndrome
    Masao Koshikawa
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan
    J Am Soc Nephrol 16:2690-701. 2005
    ..These findings indicate that the activation of MAPK is necessary for podocyte injury, suggesting that p38 MAPK and, possibly, ERK should become a potential target for therapeutic intervention in proteinuric glomerulopathies...
  87. ncbi Nephrin expression in the post-natal developing kidney in normotensive and hypertensive rats
    Fabrice Bonnet
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg West, Victoria, Australia
    Clin Exp Hypertens 24:371-81. 2002
    ....