H Kawachi

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. pmc Curcumin ameliorates macrophage infiltration by inhibiting NF-κB activation and proinflammatory cytokines in streptozotocin induced-diabetic nephropathy
    Vivian Soetikno
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    Nutr Metab (Lond) 8:35. 2011
  2. ncbi request reprint Therapeutic targets in the podocyte: findings in anti-slit diaphragm antibody-induced nephropathy
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Nephrol 22:450-6. 2009
  3. doi request reprint Slit diaphragm dysfunction in proteinuric states: identification of novel therapeutic targets for nephrotic syndrome
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Clin Exp Nephrol 13:275-80. 2009
  4. ncbi request reprint mAb 5-1-6 nephropathy and nephrin
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Faculty of Medicine, Niigata University, Niigata 951 8510 Japan
    Microsc Res Tech 57:236-40. 2002
  5. ncbi request reprint Cloning of rat homologue of podocin: expression in proteinuric states and in developing glomeruli
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Am Soc Nephrol 14:46-56. 2003
  6. ncbi request reprint Role of podocyte slit diaphragm as a filtration barrier
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Nephrology (Carlton) 11:274-81. 2006
  7. ncbi request reprint Cloning of rat nephrin: expression in developing glomeruli and in proteinuric states
    H Kawachi
    Department of Cell Biology and Department of Pathology, Institute of Nephrology, Niigata University School of Medicine, Japan
    Kidney Int 57:1949-61. 2000
  8. ncbi request reprint Crescent-forming mechanism in an irreversible Thy-1 model in rats
    A Oyanagi
    Department of Cell Biology, Institute of Nephrology, Niigata University School of Medicine, Niigata, Japan
    Nephron 89:439-47. 2001
  9. ncbi request reprint FAT is a component of glomerular slit diaphragms
    T Inoue
    Department of Renal Pathology, Institute of Nephrology, Faculty of Medicine, Niigata University, Niigata, Japan
    Kidney Int 59:1003-12. 2001
  10. ncbi request reprint Synaptic vesicle protein 2B is expressed in podocyte, and its expression is altered in proteinuric glomeruli
    Naoko Miyauchi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    J Am Soc Nephrol 17:2748-59. 2006

Collaborators

Detail Information

Publications87

  1. pmc Curcumin ameliorates macrophage infiltration by inhibiting NF-κB activation and proinflammatory cytokines in streptozotocin induced-diabetic nephropathy
    Vivian Soetikno
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    Nutr Metab (Lond) 8:35. 2011
    ..We hypothesized that the plant polyphenolic compound curcumin, which is known to exert potent anti-inflammatory effect, would ameliorate macrophage infiltration in streptozotocin (STZ)-induced diabetic rats...
  2. ncbi request reprint Therapeutic targets in the podocyte: findings in anti-slit diaphragm antibody-induced nephropathy
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Nephrol 22:450-6. 2009
    ..In vivo and in vitro studies demonstrated that angiotensin II type 2 receptor-mediated action enhanced the expression of nephrin. We propose that these molecules could be novel therapeutic targets for proteinuria...
  3. doi request reprint Slit diaphragm dysfunction in proteinuric states: identification of novel therapeutic targets for nephrotic syndrome
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Clin Exp Nephrol 13:275-80. 2009
    ..By the subtraction hybridization techniques using glomerular cDNA of normal and proteinuric rats, we detected that synaptic vesicle protein 2B and ephrin B1 are involved in the maintenance of the barrier function of the slit diaphragm...
  4. ncbi request reprint mAb 5-1-6 nephropathy and nephrin
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Faculty of Medicine, Niigata University, Niigata 951 8510 Japan
    Microsc Res Tech 57:236-40. 2002
    ..To better understand the structure of the slit diaphragm, it is particularly important to identify other components that build up the structure of the slit diaphragm together with nephrin...
  5. ncbi request reprint Cloning of rat homologue of podocin: expression in proteinuric states and in developing glomeruli
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Am Soc Nephrol 14:46-56. 2003
    ..It is postulated that podocin is one of the critical components of a slit diaphragm for maintaining the barrier function of the glomerular capillary wall...
  6. ncbi request reprint Role of podocyte slit diaphragm as a filtration barrier
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Nephrology (Carlton) 11:274-81. 2006
    ..These observations suggested that alteration of the molecular arrangement in the slit diaphragm is involved in the development of proteinuria in several kinds of glomerular diseases...
  7. ncbi request reprint Cloning of rat nephrin: expression in developing glomeruli and in proteinuric states
    H Kawachi
    Department of Cell Biology and Department of Pathology, Institute of Nephrology, Niigata University School of Medicine, Japan
    Kidney Int 57:1949-61. 2000
    ..Nephrin is identified as a product of the gene mutated in a patient with congenital nephrotic syndrome of the Finnish type. However, its precise localization and function are not yet fully clarified...
  8. ncbi request reprint Crescent-forming mechanism in an irreversible Thy-1 model in rats
    A Oyanagi
    Department of Cell Biology, Institute of Nephrology, Niigata University School of Medicine, Niigata, Japan
    Nephron 89:439-47. 2001
    ....
  9. ncbi request reprint FAT is a component of glomerular slit diaphragms
    T Inoue
    Department of Renal Pathology, Institute of Nephrology, Faculty of Medicine, Niigata University, Niigata, Japan
    Kidney Int 59:1003-12. 2001
    ..CONCLUSION: The molecular structure of FAT and its colocalization with 5-1-6 antigen and ZO-1 indicate that FAT is a component of slit diaphragms...
  10. ncbi request reprint Synaptic vesicle protein 2B is expressed in podocyte, and its expression is altered in proteinuric glomeruli
    Naoko Miyauchi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    J Am Soc Nephrol 17:2748-59. 2006
    ..These results suggest that SV2B is a functional molecule of podocyte, and SV2B may play a role in the expression and proper localization of CD2AP...
  11. doi request reprint Dissociation of NEPH1 from nephrin is involved in development of a rat model of focal segmental glomerulosclerosis
    Yasuhiro Otaki
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, 951 8510, Japan
    Am J Physiol Renal Physiol 295:F1376-87. 2008
    ..It is postulated that the dissociation of NEPH1 from nephrin initiates proteinuria and that the SD alteration restricted in these molecules plays a critical role in the development of sclerotic changes in FSGS...
  12. ncbi request reprint Ephrin-B1 localizes at the slit diaphragm of the glomerular podocyte
    T Hashimoto
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Kidney Int 72:954-64. 2007
    ..We suggest that ephrin-B1 has a role in maintaining barrier function at the slit diaphragm...
  13. ncbi request reprint Role of mesangial cell damage in progressive renal disease
    F Shimizu
    Department of Cell Biology, Institute of Nephrology, Niigata University School of Medicine, Asahimachi Dori, Niigata, Japan
    Kidney Blood Press Res 22:5-12. 1999
    ..1 molecule, are expected to provide new insights into mechanisms of irreversible renal injury initiated by mesangial cell damage and also to develop novel and rational therapeutic approaches to progressive, primarily mesangial diseases...
  14. ncbi request reprint Blocking angiotensin II ameliorates proteinuria and glomerular lesions in progressive mesangioproliferative glomerulonephritis
    T Nakamura
    Division of Blood Transfusion, Department of Internal Medicine, Niigata University School of Medicine, Niigata, Japan
    Kidney Int 55:877-89. 1999
    ....
  15. ncbi request reprint Nephrin and podocin dissociate at the onset of proteinuria in experimental membranous nephropathy
    Takeshi Nakatsue
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Kidney Int 67:2239-53. 2005
    ..The pathogenic mechanism of proteinuria in membranous nephropathy remains uncertain. This study was undertaken to analyze the pathogenic role of slit diaphragm in proteinuria in experimental membranous nephropathy...
  16. ncbi request reprint Podocyte injuries exacerbate mesangial proliferative glomerulonephritis
    Y Morioka
    Department of Cell Biology, Institute of Nephrology, Faculty of Medicine, Niigata University, Japan
    Kidney Int 60:2192-204. 2001
    ..The irreversible mesangial alterations caused by consecutive injections of PAN and mAb 1-22-3 may be a novel model that could be used to analyze the mechanism of progressive mesangial alteration...
  17. ncbi request reprint Expression of allograft inflammatory factor-1 in kidneys: A novel molecular component of podocyte
    Y Tsubata
    Department of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Kidney Int 70:1948-54. 2006
    ....
  18. ncbi request reprint An anti-CD5 monoclonal antibody ameliorates proteinuria and glomerular lesions in rat mesangioproliferative glomerulonephritis
    Y Ikezumi
    Department of Cell Biology, Institute of Nephrology, Niigata University School of Medicine, Japan
    Kidney Int 58:100-14. 2000
    ..In this study, we elucidated the role of lymphocytes in the development of mesangial proliferative GN...
  19. ncbi request reprint Glomerular CD8+ cells predict progression of childhood IgA nephropathy
    T Watanabe
    Department of Cell Biology, Institute of Nephrology, Faculty of Medicine, Niigata University, Japan
    Pediatr Nephrol 16:561-7. 2001
    ..In conclusion, these results indicate that the number of glomerular CD8+ cells is the most sensitive predictor of disease progression in childhood IgAN...
  20. pmc Angiotensin II type 1 and type 2 receptors play opposite roles in regulating the barrier function of kidney glomerular capillary wall
    Koichi Suzuki
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, 951 8510, Japan
    Am J Pathol 170:1841-53. 2007
    ....
  21. ncbi request reprint FK506 ameliorates proteinuria and glomerular lesions induced by anti-Thy 1.1 monoclonal antibody 1-22-3
    Yohei Ikezumi
    Department of Cell Biology, Institute of Nephrology, and Department of Pediatrics, Faculty of Medicine, Niigata University, Niigata, Japan
    Kidney Int 61:1339-50. 2002
    ..The aims of this study were to elucidate the role of Th1 cytokines on mesangial alteration and to examine whether FK506 is available for therapy of mesangial proliferative GN...
  22. ncbi request reprint [Novel functional molecules of slit membrane]
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences
    Nihon Rinsho 62:1823-8. 2004
    ..These studies indicated that the precise arrangement and the interaction of these molecules are essential for maintaining the barrier function of slit membrane...
  23. ncbi request reprint Decreased collagen-degrading activity could be a marker of prolonged mesangial matrix expansion
    Masayuki Tomita
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, 951 8510, Niigata, Japan
    Clin Exp Nephrol 8:17-26. 2004
    ..We aimed to elucidate the relative role of the matrix metalloproteinase (MMP)/tissue inhibitors of metalloproteinases (TIMPs) system in the development of prolonged mesangial matrix expansion...
  24. ncbi request reprint Monoclonal antibody against rat podocyte-derived macrophagic cells reacts with crescent-forming cells in an experimental model
    Michiaki Orikasa
    Department of Biomedical Technology, School of Health Science, Faculty of Medicine, Niigata University, Niigata, Japan
    Nephrology (Carlton) 8:217-23. 2003
    ..We propose a novel concept of crescent formation, suggesting that crescents may be partly composed of phenotypically changed cells, which could not be detected by typical markers for glomerular epithelial cells or monocytes/macrophages...
  25. ncbi request reprint Fractalkine expression and the recruitment of CX3CR1+ cells in the prolonged mesangial proliferative glomerulonephritis
    Yumi Ito
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Kidney Int 61:2044-57. 2002
    ..However, the essential factors leading to the prolonged glomerular alterations have not been identified...
  26. ncbi request reprint [Structure and function of podocyte]
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences
    Nihon Rinsho 64:70-3. 2006
  27. ncbi request reprint IFN-inducible protein-10 plays a pivotal role in maintaining slit-diaphragm function by regulating podocyte cell-cycle balance
    Gi Dong Han
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    J Am Soc Nephrol 17:442-53. 2006
    ..These results raise the possibility that IP-10 could become a novel therapeutic target in nephrotic syndrome and several diseases with altered cell-cycle balance...
  28. ncbi request reprint Multi-glycoside of Tripterygium wilfordii Hook f. ameliorates proteinuria and acute mesangial injury induced by anti-Thy1.1 monoclonal antibody
    Yigang Wan
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Nephron Exp Nephrol 99:e121-9. 2005
    ..1.1 glomerulonephritis (Thy1.1GN) model and then to clarify the action mechanism of GTW at molecular level by examining its effects on various injurious factors in this model...
  29. ncbi request reprint SM22alpha: the novel phenotype marker of injured glomerular epithelial cells in anti-glomerular basement membrane nephritis
    Asa Ogawa
    Division of Clinical Nephrology and Rheumatology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Nephron Exp Nephrol 106:e77-87. 2007
    ..SM22alpha is a 22-kDa cytoskeletal protein that is exclusively expressed in smooth muscle cells. We investigated the localization of SM22alpha at mRNA and protein levels, and its pathological significance in anti-GBM nephritis kidneys...
  30. doi request reprint Activated macrophages down-regulate podocyte nephrin and podocin expression via stress-activated protein kinases
    Yohei Ikezumi
    Department of Pediatrics, Niigata University Medical and Dental Hospital, 1 757 Asahimachi dori, Chuo Ku, Asahimachi Dori, Niigata 951 8510, Japan
    Biochem Biophys Res Commun 376:706-11. 2008
    ..This study demonstrates that activated macrophages can induce podocyte injury via a TNFalpha-JNK/p38-dependent mechanism. This may explain, in part, the protective effects of JNK and p38 blockade in experimental kidney disease...
  31. ncbi request reprint Attenuation of mouse acute colitis by naked hepatocyte growth factor gene transfer into the liver
    Takayasu Hanawa
    Department of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City, Niigata 951 8510, Japan
    J Gene Med 8:623-35. 2006
    ..Hepatocyte growth factor (HGF) has multiple biological effects on a wide variety of cells. It modulates intestinal epithelial proliferation and migration, and critically regulates intestinal wound healing...
  32. ncbi request reprint Use of mizoribine as a rescue drug for steroid-resistant pediatric IgA nephropathy
    Yohei Ikezumi
    Department of Pediatrics, Niigata University Medical and Dental Hospital, Asahimachi Dori, Niigata, Japan
    Pediatr Nephrol 23:645-50. 2008
    ..The ability of Miz to reduce the number of activated macrophages may be an important mechanism by which this drug ameliorated renal disease in these patients...
  33. ncbi request reprint Altered expression of junctional adhesion molecule 4 in injured podocytes
    Yutaka Harita
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Am J Physiol Renal Physiol 290:F335-44. 2006
    ..JAM4 may have a different role at the apical membrane besides the role as a junctional molecule and is likely associated with the unique structure of this epithelium...
  34. ncbi request reprint The sialoadhesin (CD169) expressing a macrophage subset in human proliferative glomerulonephritis
    Yohei Ikezumi
    Division of Pediatrics, Niigata University Medical and Dental Hospital, Asahimachi Dori, Niigata 951 8510, Japan
    Nephrol Dial Transplant 20:2704-13. 2005
    ..The current study examined the significance of Sn+ macrophages in human proliferative glomerulonephritis...
  35. ncbi request reprint Kidney-targeted naked DNA transfer by retrograde renal vein injection in rats
    Hiroki Maruyama
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8120, Japan
    Hum Gene Ther 13:455-68. 2002
    ..This novel technique is simple and safe, allowing high-level and long-term stable gene expression specific to the fibroblasts near the PTC, and should have therapeutic value for future applications in humans...
  36. doi request reprint Contrasting effects of steroids and mizoribine on macrophage activation and glomerular lesions in rat thy-1 mesangial proliferative glomerulonephritis
    Yohei Ikezumi
    Department of Pediatrics, Niigata University Medical and Dental Hospital, Japan
    Am J Nephrol 31:273-82. 2010
    ..In addition, clinical studies have suggested that the ability of mizoribine (MZR) to suppress steroid-resistant proliferative glomerulonephritis may operate via inhibiting pro-inflammatory macrophage activation...
  37. ncbi request reprint Histological differences in new-onset IgA nephropathy between children and adults
    Yohei Ikezumi
    Department of Pediatrics, Niigata University Medical and Dental Hospital, Asahimachi Dori, Niigata 951 8510, Japan
    Nephrol Dial Transplant 21:3466-74. 2006
    ..We addressed this question by comparing both histology and leucocyte accumulation in biopsies of recently diagnosed childhood and adult IgAN...
  38. ncbi request reprint Kinetic analysis of the development of pancreatic lesions in mice infected with a murine retrovirus
    Shiro Watanabe
    Department of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Clin Immunol 109:212-23. 2003
    ..Thus, MAIDS mice could be valuable for analyzing the pathogenesis of autoimmune-related pancreatitis associated with SjS...
  39. ncbi request reprint Genetic polymorphism of NPHS1 modifies the clinical manifestations of Ig A nephropathy
    Ichiei Narita
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi Dori, Niigata, Japan
    Lab Invest 83:1193-200. 2003
    ..This study suggests that the NPHS1 G349A polymorphism may be associated with heavy proteinuria and a decline in renal function in patients with IgAN...
  40. doi request reprint Effects of mineralocorticoid and angiotensin II receptor blockers on proteinuria and glomerular podocyte protein expression in a model of minimal change nephrotic syndrome
    Akihiro Fukuda
    Division of Circulatory and Body Fluid Regulation, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki, 889 1692, Japan
    Nephrology (Carlton) 15:321-6. 2010
    ..However, the effects of AR and/or MR blockers in a model of acute nephrotic syndrome remain unknown. The effects of AR and MR blockers were examined in puromycin aminonucleoside (PAN)-treated rats...
  41. doi request reprint Analysis of intestinal fibrosis in chronic colitis in mice induced by dextran sulfate sodium
    Kenji Suzuki
    Department of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata City, Niigata, Japan
    Pathol Int 61:228-38. 2011
    ..In conclusion, profibrogenic mesenchymal cells play an important role in the development of intestinal fibrosis in this chronic DSS-induced colitis model...
  42. ncbi request reprint IFN-inducible protein-10 has a differential role in podocyte during Thy 1.1 glomerulonephritis
    Gi Dong Han
    Department of Cell Biology, Institute of Nephrology, Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Am Soc Nephrol 14:3111-26. 2003
    ..Also, the findings suggested that anti-IP-10 treatment exacerbated the glomerular alterations in Thy1.1 GN by disturbing the podocyte function...
  43. doi request reprint Identification of alternatively activated macrophages in new-onset paediatric and adult immunoglobulin A nephropathy: potential role in mesangial matrix expansion
    Yohei Ikezumi
    Department of Pediatrics, Niigata University Medical and Dental Hospital, Niigata 951 8510 Japan
    Histopathology 58:198-210. 2011
    ..Therefore, the aim of this study was to investigate whether M2 macrophages are present in new-onset IgAN and if they are related to pathological differences between paediatric and adult disease...
  44. ncbi request reprint Blockade of interferon-gamma-inducible protein-10 attenuates chronic experimental colitis by blocking cellular trafficking and protecting intestinal epithelial cells
    Kenji Suzuki
    Department of Gastroenterology, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Pathol Int 57:413-20. 2007
    ....
  45. doi request reprint Rectal administration of tranilast ameliorated acute colitis in mice through increased expression of heme oxygenase-1
    Xiaomei Sun
    Department of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Pathol Int 60:93-101. 2010
    ..Tranilast might exert these effects partly through enhanced HO-1 expression in the colon, suggesting a potential adjunctive therapy for IBD...
  46. ncbi request reprint Molecular structure and function of the slit diaphragm: expression of nephrin in proteinuric states and in developing glomeruli
    Hiroshi Kawachi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Nephrol Dial Transplant 17:20-2. 2002
    ..With the interdigitation of foot processes, nephrin becomes concentrated in the slit pore, and finally restricted in the site of the slit diaphragm bridging two adjacent foot processes...
  47. ncbi request reprint Role of IP-10/CXCL10 in the progression of pancreatitis-like injury in mice after murine retroviral infection
    Yusuke Kawauchi
    Department of Gastroenterology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
    Am J Physiol Gastrointest Liver Physiol 291:G345-54. 2006
    ....
  48. ncbi request reprint Novel expression of sodium/myo-inositol co-transporter in podocytes in puromycin aminonucleoside nephrosis
    Yusuke Watanabe
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, 1 757 Asahimachi dori, Niigata, 951 8510, Japan
    Nephrol Dial Transplant 19:817-22. 2004
    ..In the present study, we investigated SMIT expression in podocytes in experimental nephrosis...
  49. ncbi request reprint Blockade of CXCL10 protects mice from acute colitis and enhances crypt cell survival
    Shunya Sasaki
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Eur J Immunol 32:3197-205. 2002
    ..Thus, CXCL10 can be a new therapeutic target for inflammatory bowel disease by controlling the dynamics of epithelial homeostasis...
  50. ncbi request reprint The role of lymphocytes in the experimental progressive glomerulonephritis
    Yohei Ikezumi
    Department of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Kidney Int 66:1036-48. 2004
    ..We examined the role of lymphocytes in the development of progressive mesangial proliferative glomerulonephritis induced by two injections of monoclonal antibody 1-22-3 in rats...
  51. ncbi request reprint A notable case report of May-Hegglin anomaly with immune complex-related nephropathy: a genetic and histological analysis
    Y Ohtsuka
    Department of Pediatrics, Faculty of Medicine, Saga University, Saga City, Japan
    Clin Nephrol 75:255-62. 2011
    ..Moreover, the expression of nephrin and podocin, slit diagram protein, was normal. An inflammatory mechanism may occur separately from MYH9-related disease. This report presents a case of MHA with immune complex-related nephropathy...
  52. ncbi request reprint Hydrodynamics-based delivery of the viral interleukin-10 gene suppresses experimental crescentic glomerulonephritis in Wistar-Kyoto rats
    N Higuchi
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Gene Ther 10:1297-310. 2003
    ..These results demonstrate that pCAGGS-vIL-10 gene transfer by hydrodynamics-based transfection suppresses crescentic glomerulonephritis...
  53. ncbi request reprint Urinary sediment podocalyxin in children with glomerular diseases
    Katsue Kanno
    Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan
    Nephron Clin Pract 95:c91-9. 2003
    ..However, this method has some problems, since it is basically urine cytology. To overcome problems with this test, we measured whole podocalyxin content in urine sediment by enzyme-linked immunosorbent assay (ELISA)...
  54. doi request reprint Neurexin-1, a presynaptic adhesion molecule, localizes at the slit diaphragm of the glomerular podocytes in kidneys
    Akira Saito
    Dept of Cell Biology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Chuo Ku, Niigata, 951 8510, Japan
    Am J Physiol Regul Integr Comp Physiol 300:R340-8. 2011
    ..These observations suggest that neurexin is involved in the formation of the slit diaphragm and the maintenance of its function...
  55. ncbi request reprint Tumor suppressor carcinoembryonic antigen-related cell adhesion molecule 1 potentates the anchorage-independent growth of human hepatoma HepG2 cells
    Mariko Hokari
    Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi dori 1 757, Niigata 951 8510, Japan
    Life Sci 81:336-45. 2007
    ....
  56. pmc Selective loss of podoplanin protein expression accompanies proteinuria and precedes alterations in podocyte morphology in a spontaneous proteinuric rat model
    Klaas Koop
    Department of Pathology, Leiden University Medical Center, Building 1, L1 Q, PO Box 9600, 2300 RC Leiden, The Netherlands
    Am J Pathol 173:315-26. 2008
    ..Our study suggests that decreased expression of podoplanin plays a role in the decrease of glomerular permselectivity...
  57. doi request reprint Suppressive activity of pemirolast potassium, an antiallergic drug, on glomerulonephritis. Studies in glomerulonephritis model rats and in patients with chronic glomerulonephritis concurrently affected by allergic rhinitis
    Tomohito Gohda
    Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Arzneimittelforschung 58:18-23. 2008
    ..Therefore, an alternative approach is greatly required. Pemirolast potassium (CAS 100299-08-9) is an antiallergic drug with high safety...
  58. doi request reprint Rosuvastatin is additive to high-dose candesartan in slowing progression of experimental mesangioproliferative glomerulosclerosis
    Stephanie Kramer
    Dept of Nephrology, Charite Universitatsmedizin Berlin, Campus Mitte, Humboldt Univ, Chariteplatz 1, D 10098 Berlin, Germany
    Am J Physiol Renal Physiol 294:F801-11. 2008
    ..The results suggest that rosuvastatin and an AT(1) blocker independently interfere with separate key pathways involved in the progression of chronic mesangioproliferative GS...
  59. ncbi request reprint Low-dose mTOR inhibition by rapamycin attenuates progression in anti-thy1-induced chronic glomerulosclerosis of the rat
    Stephanie Kramer
    Department of Nephrology and Center for Cardiovascular Research, Charite Universitatsmedizin Berlin, Charite Campus Mitte, Humboldt University, Berlin, Germany
    Am J Physiol Renal Physiol 294:F440-9. 2008
    ..e., proteinuria, extracellular matrix accumulation, renal cell proliferation, and inflammatory cell infiltration...
  60. ncbi request reprint [Function of the podocyte slit diaphragm]
    Hiroshi Kawachi
    Nihon Jinzo Gakkai Shi 49:77-81. 2007
  61. ncbi request reprint Blockade of IP-10/CXCR3 promotes progressive renal fibrosis
    Izaya Nakaya
    Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Nephron Exp Nephrol 107:e12-21. 2007
    ..However, the involvement of IP-10 in the pathogenesis of renal diseases via its receptor, CXCR3, remains unclear. To contribute to the clarification of this issue was the aim of this study...
  62. ncbi request reprint Modulation of nephrin in the diabetic kidney: association with systemic hypertension and increasing albuminuria
    Josephine M Forbes
    Department of Medicine and Endocrinology, University of Melbourne, Austin, Australia
    J Hypertens 20:985-92. 2002
    ..This study examines the possible relationship between nephrin expression and albuminuria in normotensive and hypertensive diabetic rats...
  63. ncbi request reprint Rat nephrin modulates cell morphology via the adaptor protein Nck
    Hongping Li
    Department of Medicine, McGill University, Montreal, Que, Canada
    Biochem Biophys Res Commun 349:310-6. 2006
    ..Taken together, we propose that Nck couples nephrin to the actin cytoskeleton in glomerular podocytes and contributes to the maintenance of normal morphology and function of podocytes...
  64. ncbi request reprint Mycophenolate mofetil slows progression in anti-thy1-induced chronic renal fibrosis but is not additive to a high dose of enalapril
    Stephanie Kramer
    Department of Nephrology, Charite University Medicine Berlin, Germany
    Am J Physiol Renal Physiol 289:F359-68. 2005
    ..The dual anti-inflammatory/anti-fibrotic intervention does not yield additive renoprotective effects, indicating that MMF and enalapril interfere with similar or very closely related pathways involved in progression of renal disease...
  65. ncbi request reprint SRC-family kinase Fyn phosphorylates the cytoplasmic domain of nephrin and modulates its interaction with podocin
    Hongping Li
    McGill University Health Centre, 3775 University Street, Room 236, Montreal, Quebec, Canada H3A 2B4
    J Am Soc Nephrol 15:3006-15. 2004
    ..In summary, Fyn phosphorylates the cytoplasmic domain of nephrin on tyrosine, leading to enhanced association with podocin and downstream signaling of nephrin...
  66. ncbi request reprint Prevention and reversal of renal injury by leptin in a new mouse model of diabetic nephropathy
    Takayoshi Suganami
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    FASEB J 19:127-9. 2005
    ..The model presented here will serve as a novel tool to analyze the molecular mechanism underlying not only the progression but also the regression of diabetic nephropathy...
  67. ncbi request reprint [Current topics. 1. Molecular mechanism involved in proteinuria]
    Hiroshi Kawachi
    Nihon Naika Gakkai Zasshi 93:954-9. 2004
  68. ncbi request reprint Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat
    Matthias Schaier
    Department of Nephrology, University Hospital, University of Heidelberg, Bergheimer Strasse 56a, 69115, Heidelberg, Germany
    J Mol Med (Berl) 82:116-25. 2004
    ..Receptor-specific retinoids may provide a novel therapeutic approach for the treatment of chronic glomerulonephritis...
  69. ncbi request reprint [Molecular mechanism responsible for the development of proteinuria: clinical significance of nephrin nephrotic syndrome]
    Fujio Shimizu
    Nihon Naika Gakkai Zasshi 92:1337-43. 2003
  70. ncbi request reprint Expression of podocyte-associated molecules in acquired human kidney diseases
    Klaas Koop
    Departments of Pathology and Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Soc Nephrol 14:2063-71. 2003
    ..This suggests that the alterations in the expression of podocyte-associated molecules represent a compensatory reaction of the podocyte that results from damage associated with proteinuria...
  71. ncbi request reprint Moderate alcohol intake has no impact on acute and chronic progressive anti-thy1 glomerulonephritis
    Harm Peters
    Division of Nephrology, Charite, Campus Mitte, Humboldt University, D 10098 Berlin, Germany
    Am J Physiol Renal Physiol 284:F1105-14. 2003
    ..The study suggests that, in contrast to cardiovascular disorders, moderate alcohol consumption might not provide specific protection in renal fibrotic disease...
  72. ncbi request reprint Disparate effects of angiotensin II antagonists and calcium channel blockers on albuminuria in experimental diabetes and hypertension: potential role of nephrin
    Belinda J Davis
    Department of Medicine, University of Melbourne, Repatriation Campus, Heidelberg West, Victoria 3081, Australia
    J Hypertens 21:209-16. 2003
    ....
  73. ncbi request reprint Therapeutic effect of sulphated hyaluronic acid, a potential selectin-blocking agent, on experimental progressive mesangial proliferative glomerulonephritis
    Mitsuhiro Matsuda
    Department of Medicine III, Okayama University Medical School, Japan
    J Pathol 198:407-14. 2002
    ..Sulphated oligosaccharides may be beneficial for the therapy of mesangial proliferative glomerulonephritis...
  74. ncbi request reprint Expression and regulation of adrenomedullin in renal glomerular podocytes
    Masayo Hino
    Department of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 330:178-85. 2005
    ..These results indicated that AM expression in the podocytes was upregulated by stimuli or condition relevant to podocyte injury, suggesting its potential role in podocyte pathophysiology...
  75. ncbi request reprint Spironolactone in combination with cilazapril ameliorates proteinuria and renal interstitial fibrosis in rats with anti-Thy-1 irreversible nephritis
    Masaki Asai
    Department of Internal Medicine, Keio University School of Medicine, Shinanomachi, Tokyo, Japan
    Hypertens Res 27:971-8. 2004
    ..These data suggest that concomitant treatment with spironolactone and an ACE inhibitor has beneficial effects on immune-initiated progressive kidney disease...
  76. ncbi request reprint Stimulation of soluble guanylate cyclase slows progression in anti-thy1-induced chronic glomerulosclerosis
    Yingrui Wang
    Department of Nephrology and Center of Cardiovascular Research, Charite University Medicine Berlin, Charite Campus Mitte, Humboldt University, Berlin, Germany
    Kidney Int 68:47-61. 2005
    ....
  77. ncbi request reprint Antagonism of PDGF-D by human antibody CR002 prevents renal scarring in experimental glomerulonephritis
    Tammo Ostendorf
    Division of Nephrology, University Hospital Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    J Am Soc Nephrol 17:1054-62. 2006
    ..In conclusion, these data provide evidence for a causal role of PDGF-D in the pathogenesis of renal scarring and point to a new therapeutic approach to progressive mesangioproliferative renal disease...
  78. ncbi request reprint Addition of the antioxidant probucol to angiotensin II type I receptor antagonist arrests progressive mesangioproliferative glomerulonephritis in the rat
    Shuji Kondo
    Department of Pediatrics, The Institute of Health Bioscience, The University of Tokushima Graduate School, Kuramoto cho 3 chome, Tokushima 770 8503, Japan
    J Am Soc Nephrol 17:783-94. 2006
    ..The combination of probucol and candesartan may represent a novel route of therapy for patients with progressive GN...
  79. pmc Pathophysiologic implications of reduced podocyte number in a rat model of progressive glomerular injury
    Daniela Macconi
    Mario Negri Institute for Pharmacological Research, Via Gavazzeni 11, 24125 Bergamo, Italy
    Am J Pathol 168:42-54. 2006
    ....
  80. ncbi request reprint Exogenous 5'-nucleotidase improves glomerular autoregulation in Thy-1 nephritic rats
    Tsuneo Takenaka
    Department of Nephrology, Saitama Medical College, Iruma Saitama 350 0495, Japan
    Am J Physiol Renal Physiol 290:F844-53. 2006
    ..Finally, our findings suggest that mesangial cells and/or 5'-nucleotidase plays an important role in mediating renal autoregulation...
  81. ncbi request reprint MAGI-1 is a component of the glomerular slit diaphragm that is tightly associated with nephrin
    Susumu Hirabayashi
    Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Lab Invest 85:1528-43. 2005
    ..MAGI-1 may play a role in determining the boundary between the apical and the bosolateral domain at the level of slit diaphragm...
  82. ncbi request reprint Continuous, noninvasive monitoring of local microscopic inflammation using a genetically engineered cell-based biosensor
    Yiman Meng
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan and Organ Transplantation Unit, 1st Affiliated Hospital, China Medical University, Shenyang, China
    Lab Invest 85:1429-39. 2005
    ..These results suggested that, without invasive procedures like tissue biopsies, continuous monitoring of microscopic inflammation is feasible in vivo via locally created, cell-based biosensors...
  83. ncbi request reprint Monoclonal antibody 1-22-3-induced glomerulonephritis in uninephrectomized rats as a model of progressive renal failure
    Masayuki Tomita
    Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co, Ltd, Osaka, Japan
    Nephrol Dial Transplant 20:2358-67. 2005
    ..In the current study, we examined the usefulness of anti-Thy-1 monoclonal antibody (mAb) 1-22-3-induced GN in uninephrectomized rats as a model of progressive renal failure by analysing the similarities to human disease...
  84. ncbi request reprint Enhancing cGMP in experimental progressive renal fibrosis: soluble guanylate cyclase stimulation vs. phosphodiesterase inhibition
    Yingrui Wang
    Dept of Nephrology, Charite, Campus Mitte, Humboldt Univ, Schumannstrasse 20 21, D 10098 Berlin, Germany
    Am J Physiol Renal Physiol 290:F167-76. 2006
    ..The findings indicate that pharmacological enhancement of renal cGMP levels by sGC stimulation represents a novel and effective antifibrotic approach in progressive kidney disorders...
  85. ncbi request reprint Infusion of angiotensin II reduces loss of glomerular capillary area in the early phase of anti-Thy-1.1 nephritis possibly via regulating angiogenesis-associated factors
    Yuki Takazawa
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Kidney Int 68:704-22. 2005
    ....
  86. ncbi request reprint Role of p38 mitogen-activated protein kinase activation in podocyte injury and proteinuria in experimental nephrotic syndrome
    Masao Koshikawa
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Am Soc Nephrol 16:2690-701. 2005
    ..These findings indicate that the activation of MAPK is necessary for podocyte injury, suggesting that p38 MAPK and, possibly, ERK should become a potential target for therapeutic intervention in proteinuric glomerulopathies...
  87. ncbi request reprint Nephrin expression in the post-natal developing kidney in normotensive and hypertensive rats
    Fabrice Bonnet
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg West, Victoria, Australia
    Clin Exp Hypertens 24:371-81. 2002
    ....