Research Topics
Genomes and Genes | Naoko InamuraSummaryAffiliation: Niigata University Country: Japan Publications
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Detail Information
Publications
BDNF and NT-3 but not CNTF counteract the Ca2+ ionophore-induced apoptosis of cultured cortical neurons: involvement of dual pathwaysN Takei
Department of Applied Biology, Kyoto Institute of Technology, Sakyo, Japan
Neuropharmacology 38:283-8. 1999..These results suggest that the neuroprotective effect of BDNF requires activation of both phosphatidylinositol-3 kinase and the Ras/MAP kinase cascade and that CNTF signaling through other pathways is without an effect in this system...- [Critical roles of translational control on higher brain function]Nobuyuki Takei
Tanpakushitsu Kakusan Koso 51:2617-23. 2006 - Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendritesNobuyuki Takei
Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
J Neurosci 24:9760-9. 2004..Taken together, these data indicate that mTOR-dependent translation activation is essential for the upregulation of local protein synthesis in neuronal dendrites... 
Brain-derived neurotrophic factor enhances the basal rate of protein synthesis by increasing active eukaryotic elongation factor 2 levels and promoting translation elongation in cortical neuronsNobuyuki Takei
Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
J Biol Chem 284:26340-8. 2009..Taken together, our results demonstrate that the increased level of active eEF2 induced by chronic BDNF stimulation enhances translational elongation processes and increases the total rate of protein synthesis in neurons...- Brain-derived neurotrophic factor enhances neuronal translation by activating multiple initiation processes: comparison with the effects of insulinN Takei
Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi 1, Niigata 951 8585, Japan
J Biol Chem 276:42818-25. 2001..These results suggest strongly that BDNF simultaneously activates multiple signaling cascades consisting of phosphatidylinositol 3-kinase, mammalian TOR, and MAPK to enhance translation initiation in neurons... - Enhancement of translation elongation in neurons by brain-derived neurotrophic factor: implications for mammalian target of rapamycin signalingNaoko Inamura
Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
J Neurochem 95:1438-45. 2005..These results strongly suggest that BDNF enhances translation elongation through the activation of the mTOR-eEF2 pathway... - Developmental changes of eukaryotic initiation factor 2B subunits in rat hippocampusNaoko Inamura
Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi 1, Niigata Niigata 951 8585, Japan
Neurosci Lett 346:117-9. 2003..Aged hippocampus contained only trace amounts of these subunits. The finding that eIF2B subunit levels are high in developing hippocampus suggests that regulated protein synthesis is active in young, highly plastic brain... - Cellular and subcellular distributions of translation initiation, elongation and release factors in rat hippocampusNaoko Inamura
Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi 1, Niigata 951-8585, Japan
Brain Res Mol Brain Res 111:165-74. 2003..These results suggest that regulated protein synthesis occurs in the hippocampus, with differences existing between different subregions such as CA1, CA3 and dentate gyrus... - Müller Cells as a source of brain-derived neurotrophic factor in the retina: noradrenaline upregulates brain-derived neurotrophic factor levels in cultured rat Müller cellsMasaaki Seki
Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi, 951 8585, Nigata, Nigata, Japan
Neurochem Res 30:1163-70. 2005..These results suggest that Müller cells may act as an endogenous source of BDNF in the retina. Furthermore, induction of BDNF expression by adrenergic agonists may provide a therapeutic approach to retinal neurodegenerative disorders... - Possible involvement of BDNF release in long-lasting synapse formation induced by repetitive PKA activationNaoko Taniguchi
Department of Neuroscience, Osaka University Graduate School of Frontier Biosciences, Machikaneyama cho 1 1, Toyonaka, Osaka 560 0043, Japan
Neurosci Lett 406:38-42. 2006..The release of BDNF upon PKA activation was confirmed by phosphorylation of TrkB. These results indicate that the release of BDNF is involved in the putative signaling cascade connecting PKA activation and synapse formation... - Quantitative analyses of mRNA and protein levels of neurotrophin-3 in the rat retina during postnatal development and agingMasaaki Seki
Division of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951 8585, Japan
Jpn J Ophthalmol 48:460-4. 2004..In this study, we sought to elucidate changes in the levels of neurotrophin-3 (NT-3) in the rat retina throughout postnatal development and aging... - [Local translational control at synapse]Nobuyuki Takei
Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1, Asahimachi, Niigata 951-8585, Japan
Seikagaku 78:939-48. 2006 
Leucine induces phosphorylation and activation of p70S6K in cortical neurons via the system L amino acid transporterYuta Ishizuka
Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
J Neurochem 106:934-42. 2008..We propose that leucine plays important roles in regulating signaling by p70S6 kinase by acting as an intercellular communicator in the CNS...- Influences of dopaminergic lesion on epidermal growth factor-ErbB signals in Parkinson's disease and its model: neurotrophic implication in nigrostriatal neuronsYuriko Iwakura
Molecular Neurobiology, Brain Research Institute, Niigata University, Japan
J Neurochem 93:974-83. 2005..These findings suggest that the neurotrophic activity of EGF is maintained by afferent signals of midbrain dopaminergic neurons and is impaired in patients with Parkinson's disease... - Brain-derived neurotrophic factor signal enhances and maintains the expression of AMPA receptor-associated PDZ proteins in developing cortical neuronsHussam Jourdi
Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, 951 8585, Japan
Dev Biol 263:216-30. 2003..This work reveals a novel function of BDNF in postsynaptic development by regulating the PDZ protein expression... - PACAP and NGF cooperatively enhance choline acetyltransferase activity in postnatal basal forebrain neurons by complementary induction of its different mRNA speciesAki Yuhara
Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, 565-0871, Osaka, Japan
Biochem Biophys Res Commun 301:344-9. 2003..These results explain the cooperative neurotrophic action of NGF and PACAP on postnatal cholinergic neurons... - Involvement of brain-derived neurotrophic factor in early retinal neuropathy of streptozotocin-induced diabetes in rats: therapeutic potential of brain-derived neurotrophic factor for dopaminergic amacrine cellsMasaaki Seki
Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata, Niigata 951 8585, Japan
Diabetes 53:2412-9. 2004..These findings suggest that the early retinal neuropathy of diabetes involves the reduced expression of BDNF and can be ameliorated by an exogenous supply of this neurotrophin... - [Modulation of brain function by neurotrophins]Nobuyuki Takei
Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951-8585, Japan
Seikagaku 76:111-23. 2004 - BDNF is upregulated by postnatal development and visual experience: quantitative and immunohistochemical analyses of BDNF in the rat retinaMasaaki Seki
Department of Molecular Neurobiology, Brain Research Institute, and Division of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
Invest Ophthalmol Vis Sci 44:3211-8. 2003..CONCLUSIONS: These observations indicate that BDNF expression in RGCs is upregulated in an activity-dependent manner, whereas that in Müller cells is regulated only by development... - A novel rat orthologue and homologue for the Drosophila crooked neck gene in neural stem cells and their immediate descendantsNaoki Amada
Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi dori 1 757, Niigata 951 8585, Japan
J Biochem 133:615-23. 2003..These findings suggest that both TPR-motif-containing proteins are involved in RNA processing of mammalian neural stem cells and their immediate descendants... - In vivo administration of epidermal growth factor and its homologue attenuates developmental maturation of functional excitatory synapses in cortical GABAergic neuronsTadasato Nagano
Molecular Neurobiology, Brain Research Institute, Niigata University, 951 8585 Japan
Eur J Neurosci 25:380-90. 2007..We conclude that EGF or other ErbB1 ligand(s) attenuates a developmental increase in AMPA receptor expression and function in cortical GABAergic neurons... - Brain-derived neurotrophic factor regulates surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptors by enhancing the N-ethylmaleimide-sensitive factor/GluR2 interaction in developing neocortical neuronsMako Narisawa-Saito
Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
J Biol Chem 277:40901-10. 2002..These results reveal a novel role of BDNF in regulating the surface expression of AMPA receptors through a GluR2-NSF interaction... - Transforming growth factor alpha attenuates the functional expression of AMPA receptors in cortical GABAergic neuronsHisaaki Namba
Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata 951 8585, Japan
Mol Cell Neurosci 31:628-41. 2006..These observations reveal a negative regulatory activity of the ErbB1 ligand, TGFalpha, which reduces the input sensitivity of cortical GABAergic neurons to attenuate their inhibitory function... - Differential distributions of peptides in the epidermal growth factor family and phosphorylation of ErbB 1 receptor in adult rat brainYing shan Piao
Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi dori 1 757, Niigata 951 8585, Japan
Neurosci Lett 390:21-4. 2005..These observations suggest that the activation of brain ErbB 1 involves post-translational regulation of multiple EGF family members in a region-specific manner... - Establishment of a novel enzyme-linked immunosorbent assay for Thy-1; quantitative assessment of neuronal degenerationMasaaki Seki
Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi 1, 951-8585 Niigata, Japan
Neurosci Lett 329:185-8. 2002..We found that injection of a neurotoxin, N-methyl-D-aspartate, into the vitreous cavity reduced the Thy-1 level in the retina. Thy-1 ELISA will be useful for quantitative assessment of neurodegeneration in the CNS... - Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicityRyota Hashimoto
Molecular Neurobiology Section, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1363, USA
Neuropharmacology 43:1173-9. 2002..Taken together, these data suggest that the BDNF/TrkB pathway plays an essential role in mediating the neuroprotective effect of lithium...