Research Topics
Genomes and GenesSpecies | Takeshi IkeuchiSummaryAffiliation: Niigata University Country: Japan Publications
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Detail Information
Publications
Coordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alcα with a new ELISA systemTomoko Konno
Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
Mol Neurodegener 6:76. 2011....
Mutational analysis in early-onset familial dementia in the Japanese population. The role of PSEN1 and MAPT R406W mutationsTakeshi Ikeuchi
Department of Molecular Neuroscience, Brain Research Institute, Niigata University, Niigata, Japan
Dement Geriatr Cogn Disord 26:43-9. 2008..Although rare, a tau-related dementia with mutations in the microtubule-associated protein tau gene (MAPT) has been identified in patients showing clinical presentations similar to those of AD...- Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementiaTakeshi Ikeuchi
Department of Molecular Neuroscience, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951 8585, Japan
Arch Neurol 65:514-9. 2008..Multiplication of the alpha-synuclein gene (SNCA) (OMIM 163890) has been identified as a causative mutation in hereditary Parkinson disease or dementia with Lewy bodies... - Increased levels of soluble LR11 in cerebrospinal fluid of patients with Alzheimer diseaseTakeshi Ikeuchi
Department of Molecular Neuroscience, Brain Research Institute, Niigata University, Niigata, Japan
Dement Geriatr Cogn Disord 30:28-32. 2010..We have recently established a novel sandwich ELISA, which enabled the sensitive quantification of a soluble LR11 (sLR11). By this ELISA, we attempted to determine the difference in the levels of CSF sLR11 in AD patients... - Involvement of Onuf's nucleus in Machado-Joseph disease: a morphometric and immunohistochemical studyHiroshi Shimizu
Department of Pathology, Brain Research Institute, University of Niigata, Chuo Ku, Niigata 951 8585, Japan
Acta Neuropathol 120:439-48. 2010..In conclusion, the present findings strongly suggest that neuronal loss in ON, the degree of which is highly influenced by the extent of expansion of CAG repeats, is a consistent feature in MJD... - Differential levels of alpha-synuclein, beta-amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's diseaseKensaku Kasuga
Department of Molecular Neuroscience, Brain Research Institute, Niigata University, Asahimachi 1 757, Chuo Ku, Niigata 951 8585, Japan
J Neurol Neurosurg Psychiatry 81:608-10. 2010..Here the utility of quantification of alpha-synuclein, beta-amyloid42 (Abeta42) and tau in the CSF of patients with DLB, Alzheimer's disease (AD) and other dementias was examined... - Genotype-phenotype correlations in early onset ataxia with ocular motor apraxia and hypoalbuminaemiaAkio Yokoseki
Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute, Niigata University, 1 757 Asahimachi dori, Chuo Ku, Niigata City, Niigata 951 8585, Japan
Brain 134:1387-99. 2011..In conclusion, patients with early onset ataxia with ocular motor apraxia and hypoalbuminaemia homozygous for the c.689_690insT mutation show a more severe phenotype than those with a p.Pro206Leu or p.Val263Gly mutation... 
Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's diseaseHiroyuki Kaneko
Department of Molecular Neuroscience, Center for Bioresources, Niigata University, Niigata 951 8585, Japan
J Neurosci 27:13092-7. 2007....- Long-term disability and prognosis in dentatorubral-pallidoluysian atrophy: a correlation with CAG repeat lengthArika Hasegawa
Department of Molecular Neuroscience, Brain Research Institute, Niigata University, Chuo Ku, Niigata, Japan
Mov Disord 25:1694-700. 2010..These effects of CAG repeat length may be relevant in designing future clinical therapeutic trials... - Sporadic four-repeat tauopathy with frontotemporal lobar degeneration, Parkinsonism, and motor neuron disease: a distinct clinicopathological and biochemical disease entityYong juan Fu
Department of Pathology, Brain Research Institute, University of Niigata, Chuo Ku, Japan
Acta Neuropathol 120:21-32. 2010..Based on these clinicopathological, biochemical, and genetic findings, we consider that the present three patients form a distinct 4R tauopathy associated with sporadic FTLD... - Selective occurrence of TDP-43-immunoreactive inclusions in the lower motor neurons in Machado-Joseph diseaseChun Feng Tan
Department of Pathology, Brain Research Institute, University of Niigata, 1 757 Asahimachi, Niigata, Japan
Acta Neuropathol 118:553-60. 2009..However, the immunohistochemical findings strongly suggested that in MJD, in addition to the polyglutamine-dependent disease process, TDP-43-related pathogenesis is associated with degeneration and death of the lower motor neurons... - Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-β1 via cleavage of proTGF-β1Atsushi Shiga
Department of Neurology, Brain Research Institute, Niigata University, Niigata 951 8122, Japan
Hum Mol Genet 20:1800-10. 2011..Consequently, the amount of mature TGF-β1 is reduced. These results establish a novel mechanism for regulating the amount of TGF-β1, specifically, the intracellular cleavage of proTGF-β1 in the ER... - [A late-onset case of oculopharyngeal muscular dystrophy carrying a (GCG)8 repeat expansion in the PAPBN1 gene]Takayoshi Tokutake
Department of Neurology, Brain Research Institute, Niigata University
Rinsho Shinkeigaku 45:437-40. 2005..The case of this patient emphasizes the importance of the PABPN1 gene analysis for patients showing muscular weakness involving oculopharyngeal and proximal limb muscles even when a familial occurrence of the disease is not apparent... - Alzheimer's disease: report of two autopsy cases with a clinical diagnosis of corticobasal degenerationKenichi Okazaki
Department of Pathology, Brain Research Institute, University of Niigata, Niigata, Japan
Neuropathology 30:140-8. 2010.... - TDP-43 mutation in familial amyotrophic lateral sclerosisAkio Yokoseki
Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan
Ann Neurol 63:538-42. 2008..Our findings provide a new insight into the molecular pathogenesis of ALS... - Association of HTRA1 mutations and familial ischemic cerebral small-vessel diseaseKenju Hara
Niigata University, Niigata, Japan
N Engl J Med 360:1729-39. 2009.... - Clinical and genetic characterizations of 16q-linked autosomal dominant spinocerebellar ataxia (AD-SCA) and frequency analysis of AD-SCA in the Japanese populationHiroaki Nozaki
Department of Molecular Neuroscience, Brain Research Institute, Niigata University, Niigata, Japan
Mov Disord 22:857-62. 2007..16q-SCA is not a rare subtype of Japanese AD-SCA, particularly in patients with ages at onset over 60... - A patient with fragile x-associated tremor/ataxia syndrome presenting with executive cognitive deficits and cerebral white matter lesionsKensaku Kasuga
Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan
Case Rep Neurol 3:118-23. 2011..Recognizing FXTAS patients with predominant cognitive impairment from various ethnic backgrounds would contribute to our understanding of the phenotypic variation of this disease... - Prevention of stroke and dementia by statin therapy: experimental and clinical evidence of their pleiotropic effectsTakashi Miida
Division of Clinical Preventive Medicine, Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
Pharmacol Ther 113:378-93. 2007..We include current trials in which statin therapy is initiated within 24 hr of onset of acute ischemic stroke... - [A case of amyotrophic lateral sclerosis/frontotemporal lobar degeneration with apraxia of eyelid opening]Ryuji Yajima
Department of Neurology, Brain Research Institute, Niigata University
Rinsho Shinkeigaku 50:645-50. 2010..Considering the findings of this case along with those of previous reports, we propose that there is a relatively homogeneous development of ALS-D/FTLD-MND with AEO... - α-Synuclein as CSF and Blood Biomarker of Dementia with Lewy BodiesKensaku Kasuga
Department of Neurology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA 92093, USA
Int J Alzheimers Dis 2012:437025. 2012..Here, the recent progress in the studies of α-synuclein as a biomarker of DLB and their potential clinical applications are reviewed... - Can statin therapy really reduce the risk of Alzheimer's disease and slow its progression?Takashi Miida
Division of Clinical Preventive Medicine, Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Curr Opin Lipidol 16:619-23. 2005..Statins are the most used cholesterol-lowering agents worldwide. Earlier studies suggested that they may have preventive effects in Alzheimer's disease. However, prospective studies have questioned this hypothesis... - [Progression of cluster headache to Raeder's syndrome with marked response to corticosteroid therapy: a case report]Takeshi Ikeuchi
Department of Neurology, Brain Research Institute, Niigata University
Rinsho Shinkeigaku 45:321-3. 2005..Thus, this case showed a progression from cluster headache to idiopathic Raeder's syndrome, which suggests that these two disorders might share common pathological and anatomical lesions... - A novel mutation in the GNE gene and a linkage disequilibrium in Japanese pedigreesAki Arai
Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan
Ann Neurol 52:516-9. 2002.... - DIRECT technologies for molecular cloning of genes containing expanded CAG repeatsKazuhiro Sanpei
Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan
Methods Mol Biol 217:73-81. 2003 - Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatratesSeong Hun Kim
Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Chicago, Illinois 60637, USA
J Biol Chem 278:33992-4002. 2003.... - The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavageTakeshi Ikeuchi
Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Illinois 60637, USA
J Biol Chem 278:7751-4. 2003..Our findings offer the proposal that Delta1 and Jagged2 play dual roles as activators of Notch receptor signaling and as receptors that mediate nuclear signaling events via gamma-secretase-generated cytoplasmic domains... - Multiple founder effects in Japanese families with primary torsion dystonia harboring the GAG deletion in the Tor1A (DYT1) geneTakeshi Ikeuchi
Neurogenetics 4:105-6. 2002 - Dementia and delirium in 4 patients with Machado-Joseph diseaseAtsushi Ishikawa
Department of Neurology, Niigata National Hospital, Akasaka 3 52, Kashiwazaki 945 8585, Japan
Arch Neurol 59:1804-8. 2002..Patients with MJD usually present with cerebellar ataxia, external ophthalmoplegia, pyramidal and extrapyramidal signs, and muscle wasting. However, it has been reported that these patients do not demonstrate dementia...