Takeshi Ikeuchi

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. pmc Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects
    Saori Hata
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Mol Neurodegener 7:16. 2012
  2. pmc Coordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alcα with a new ELISA system
    Tomoko Konno
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Mol Neurodegener 6:76. 2011
  3. doi request reprint Mutational analysis in early-onset familial dementia in the Japanese population. The role of PSEN1 and MAPT R406W mutations
    Takeshi Ikeuchi
    Department of Molecular Neuroscience, Brain Research Institute, Niigata University, Niigata, Japan
    Dement Geriatr Cogn Disord 26:43-9. 2008
  4. doi request reprint Increased levels of soluble LR11 in cerebrospinal fluid of patients with Alzheimer disease
    Takeshi Ikeuchi
    Department of Molecular Neuroscience, Brain Research Institute, Niigata University, Niigata, Japan
    Dement Geriatr Cogn Disord 30:28-32. 2010
  5. doi request reprint Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia
    Takeshi Ikeuchi
    Department of Molecular Neuroscience, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951 8585, Japan
    Arch Neurol 65:514-9. 2008
  6. doi request reprint Involvement of Onuf's nucleus in Machado-Joseph disease: a morphometric and immunohistochemical study
    Hiroshi Shimizu
    Department of Pathology, Brain Research Institute, University of Niigata, Chuo Ku, Niigata 951 8585, Japan
    Acta Neuropathol 120:439-48. 2010
  7. doi request reprint Genotype-phenotype correlations in early onset ataxia with ocular motor apraxia and hypoalbuminaemia
    Akio Yokoseki
    Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute, Niigata University, 1 757 Asahimachi dori, Chuo Ku, Niigata City, Niigata 951 8585, Japan
    Brain 134:1387-99. 2011
  8. doi request reprint Differential levels of alpha-synuclein, beta-amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's disease
    Kensaku Kasuga
    Department of Molecular Neuroscience, Brain Research Institute, Niigata University, Asahimachi 1 757, Chuo Ku, Niigata 951 8585, Japan
    J Neurol Neurosurg Psychiatry 81:608-10. 2010
  9. ncbi request reprint Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease
    Hiroyuki Kaneko
    Department of Molecular Neuroscience, Center for Bioresources, Niigata University, Niigata 951 8585, Japan
    J Neurosci 27:13092-7. 2007
  10. pmc Hyperphosphorylation of Tau induced by naturally secreted amyloid-β at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3β signaling pathway
    Takayoshi Tokutake
    Department of Neurology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    J Biol Chem 287:35222-33. 2012

Detail Information

Publications33

  1. pmc Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects
    Saori Hata
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Mol Neurodegener 7:16. 2012
    ..Aβ and p3-Alcα can be recovered from human cerebrospinal fluid (CSF). We have previously reported alternative processing of APP and Alcα in the CSF of some patients with sporadic mild cognitive impairment (MCI) and AD (SAD)...
  2. pmc Coordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alcα with a new ELISA system
    Tomoko Konno
    Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Mol Neurodegener 6:76. 2011
    ....
  3. doi request reprint Mutational analysis in early-onset familial dementia in the Japanese population. The role of PSEN1 and MAPT R406W mutations
    Takeshi Ikeuchi
    Department of Molecular Neuroscience, Brain Research Institute, Niigata University, Niigata, Japan
    Dement Geriatr Cogn Disord 26:43-9. 2008
    ..Although rare, a tau-related dementia with mutations in the microtubule-associated protein tau gene (MAPT) has been identified in patients showing clinical presentations similar to those of AD...
  4. doi request reprint Increased levels of soluble LR11 in cerebrospinal fluid of patients with Alzheimer disease
    Takeshi Ikeuchi
    Department of Molecular Neuroscience, Brain Research Institute, Niigata University, Niigata, Japan
    Dement Geriatr Cogn Disord 30:28-32. 2010
    ..We have recently established a novel sandwich ELISA, which enabled the sensitive quantification of a soluble LR11 (sLR11). By this ELISA, we attempted to determine the difference in the levels of CSF sLR11 in AD patients...
  5. doi request reprint Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia
    Takeshi Ikeuchi
    Department of Molecular Neuroscience, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951 8585, Japan
    Arch Neurol 65:514-9. 2008
    ..Multiplication of the alpha-synuclein gene (SNCA) (OMIM 163890) has been identified as a causative mutation in hereditary Parkinson disease or dementia with Lewy bodies...
  6. doi request reprint Involvement of Onuf's nucleus in Machado-Joseph disease: a morphometric and immunohistochemical study
    Hiroshi Shimizu
    Department of Pathology, Brain Research Institute, University of Niigata, Chuo Ku, Niigata 951 8585, Japan
    Acta Neuropathol 120:439-48. 2010
    ..In conclusion, the present findings strongly suggest that neuronal loss in ON, the degree of which is highly influenced by the extent of expansion of CAG repeats, is a consistent feature in MJD...
  7. doi request reprint Genotype-phenotype correlations in early onset ataxia with ocular motor apraxia and hypoalbuminaemia
    Akio Yokoseki
    Department of Neurology, Clinical Neuroscience Branch, Brain Research Institute, Niigata University, 1 757 Asahimachi dori, Chuo Ku, Niigata City, Niigata 951 8585, Japan
    Brain 134:1387-99. 2011
    ..In conclusion, patients with early onset ataxia with ocular motor apraxia and hypoalbuminaemia homozygous for the c.689_690insT mutation show a more severe phenotype than those with a p.Pro206Leu or p.Val263Gly mutation...
  8. doi request reprint Differential levels of alpha-synuclein, beta-amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's disease
    Kensaku Kasuga
    Department of Molecular Neuroscience, Brain Research Institute, Niigata University, Asahimachi 1 757, Chuo Ku, Niigata 951 8585, Japan
    J Neurol Neurosurg Psychiatry 81:608-10. 2010
    ..Here the utility of quantification of alpha-synuclein, beta-amyloid42 (Abeta42) and tau in the CSF of patients with DLB, Alzheimer's disease (AD) and other dementias was examined...
  9. ncbi request reprint Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease
    Hiroyuki Kaneko
    Department of Molecular Neuroscience, Center for Bioresources, Niigata University, Niigata 951 8585, Japan
    J Neurosci 27:13092-7. 2007
    ....
  10. pmc Hyperphosphorylation of Tau induced by naturally secreted amyloid-β at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3β signaling pathway
    Takayoshi Tokutake
    Department of Neurology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    J Biol Chem 287:35222-33. 2012
    ....
  11. doi request reprint Sporadic ALS with compound heterozygous mutations in the SQSTM1 gene
    Hiroshi Shimizu
    Department of Pathology, Brain Research Institute, University of Niigata, 1 757 Asahimachi, Chuo Ku, Niigata, 951 8585, Japan
    Acta Neuropathol 126:453-9. 2013
    ..Another feature of interest was concomitant Lewy body pathology. The occurrence of distinct p62 pathology in the LMNs in this patient indicates the pathogenic role of SQSTM1 mutations in the development of a subset of ALS. ..
  12. doi request reprint Sporadic four-repeat tauopathy with frontotemporal lobar degeneration, Parkinsonism, and motor neuron disease: a distinct clinicopathological and biochemical disease entity
    Yong juan Fu
    Department of Pathology, Brain Research Institute, University of Niigata, Chuo Ku, Japan
    Acta Neuropathol 120:21-32. 2010
    ..Based on these clinicopathological, biochemical, and genetic findings, we consider that the present three patients form a distinct 4R tauopathy associated with sporadic FTLD...
  13. doi request reprint Long-term disability and prognosis in dentatorubral-pallidoluysian atrophy: a correlation with CAG repeat length
    Arika Hasegawa
    Department of Molecular Neuroscience, Brain Research Institute, Niigata University, Chuo Ku, Niigata, Japan
    Mov Disord 25:1694-700. 2010
    ..These effects of CAG repeat length may be relevant in designing future clinical therapeutic trials...
  14. doi request reprint Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-β1 via cleavage of proTGF-β1
    Atsushi Shiga
    Department of Neurology, Brain Research Institute, Niigata University, Niigata 951 8122, Japan
    Hum Mol Genet 20:1800-10. 2011
    ..Consequently, the amount of mature TGF-β1 is reduced. These results establish a novel mechanism for regulating the amount of TGF-β1, specifically, the intracellular cleavage of proTGF-β1 in the ER...
  15. doi request reprint Selective occurrence of TDP-43-immunoreactive inclusions in the lower motor neurons in Machado-Joseph disease
    Chun Feng Tan
    Department of Pathology, Brain Research Institute, University of Niigata, 1 757 Asahimachi, Niigata, Japan
    Acta Neuropathol 118:553-60. 2009
    ..However, the immunohistochemical findings strongly suggested that in MJD, in addition to the polyglutamine-dependent disease process, TDP-43-related pathogenesis is associated with degeneration and death of the lower motor neurons...
  16. ncbi request reprint [A late-onset case of oculopharyngeal muscular dystrophy carrying a (GCG)8 repeat expansion in the PAPBN1 gene]
    Takayoshi Tokutake
    Department of Neurology, Brain Research Institute, Niigata University
    Rinsho Shinkeigaku 45:437-40. 2005
    ..The case of this patient emphasizes the importance of the PABPN1 gene analysis for patients showing muscular weakness involving oculopharyngeal and proximal limb muscles even when a familial occurrence of the disease is not apparent...
  17. doi request reprint Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease
    Kenju Hara
    Niigata University, Niigata, Japan
    N Engl J Med 360:1729-39. 2009
    ....
  18. doi request reprint TDP-43 mutation in familial amyotrophic lateral sclerosis
    Akio Yokoseki
    Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan
    Ann Neurol 63:538-42. 2008
    ..Our findings provide a new insight into the molecular pathogenesis of ALS...
  19. doi request reprint Alzheimer's disease: report of two autopsy cases with a clinical diagnosis of corticobasal degeneration
    Kenichi Okazaki
    Department of Pathology, Brain Research Institute, University of Niigata, Niigata, Japan
    Neuropathology 30:140-8. 2010
    ....
  20. pmc A patient with fragile x-associated tremor/ataxia syndrome presenting with executive cognitive deficits and cerebral white matter lesions
    Kensaku Kasuga
    Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan
    Case Rep Neurol 3:118-23. 2011
    ..Recognizing FXTAS patients with predominant cognitive impairment from various ethnic backgrounds would contribute to our understanding of the phenotypic variation of this disease...
  21. ncbi request reprint Clinical and genetic characterizations of 16q-linked autosomal dominant spinocerebellar ataxia (AD-SCA) and frequency analysis of AD-SCA in the Japanese population
    Hiroaki Nozaki
    Department of Molecular Neuroscience, Brain Research Institute, Niigata University, Niigata, Japan
    Mov Disord 22:857-62. 2007
    ..16q-SCA is not a rare subtype of Japanese AD-SCA, particularly in patients with ages at onset over 60...
  22. ncbi request reprint Prevention of stroke and dementia by statin therapy: experimental and clinical evidence of their pleiotropic effects
    Takashi Miida
    Division of Clinical Preventive Medicine, Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
    Pharmacol Ther 113:378-93. 2007
    ..We include current trials in which statin therapy is initiated within 24 hr of onset of acute ischemic stroke...
  23. ncbi request reprint [A case of amyotrophic lateral sclerosis/frontotemporal lobar degeneration with apraxia of eyelid opening]
    Ryuji Yajima
    Department of Neurology, Brain Research Institute, Niigata University
    Rinsho Shinkeigaku 50:645-50. 2010
    ..Considering the findings of this case along with those of previous reports, we propose that there is a relatively homogeneous development of ALS-D/FTLD-MND with AEO...
  24. pmc SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians
    Akinori Miyashita
    Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan
    PLoS ONE 8:e58618. 2013
    ..Our study highlights the importance of examining associations in multiple ethnic populations...
  25. pmc α-Synuclein as CSF and Blood Biomarker of Dementia with Lewy Bodies
    Kensaku Kasuga
    Department of Neurology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA 92093, USA
    Int J Alzheimers Dis 2012:437025. 2012
    ..Here, the recent progress in the studies of α-synuclein as a biomarker of DLB and their potential clinical applications are reviewed...
  26. ncbi request reprint Can statin therapy really reduce the risk of Alzheimer's disease and slow its progression?
    Takashi Miida
    Division of Clinical Preventive Medicine, Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Curr Opin Lipidol 16:619-23. 2005
    ..Statins are the most used cholesterol-lowering agents worldwide. Earlier studies suggested that they may have preventive effects in Alzheimer's disease. However, prospective studies have questioned this hypothesis...
  27. ncbi request reprint A novel mutation in the GNE gene and a linkage disequilibrium in Japanese pedigrees
    Aki Arai
    Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan
    Ann Neurol 52:516-9. 2002
    ....
  28. ncbi request reprint [Progression of cluster headache to Raeder's syndrome with marked response to corticosteroid therapy: a case report]
    Takeshi Ikeuchi
    Department of Neurology, Brain Research Institute, Niigata University
    Rinsho Shinkeigaku 45:321-3. 2005
    ..Thus, this case showed a progression from cluster headache to idiopathic Raeder's syndrome, which suggests that these two disorders might share common pathological and anatomical lesions...
  29. ncbi request reprint DIRECT technologies for molecular cloning of genes containing expanded CAG repeats
    Kazuhiro Sanpei
    Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan
    Methods Mol Biol 217:73-81. 2003
  30. ncbi request reprint The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage
    Takeshi Ikeuchi
    Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Illinois 60637, USA
    J Biol Chem 278:7751-4. 2003
    ..Our findings offer the proposal that Delta1 and Jagged2 play dual roles as activators of Notch receptor signaling and as receptors that mediate nuclear signaling events via gamma-secretase-generated cytoplasmic domains...
  31. ncbi request reprint Multiple founder effects in Japanese families with primary torsion dystonia harboring the GAG deletion in the Tor1A (DYT1) gene
    Takeshi Ikeuchi
    Neurogenetics 4:105-6. 2002
  32. ncbi request reprint Dementia and delirium in 4 patients with Machado-Joseph disease
    Atsushi Ishikawa
    Department of Neurology, Niigata National Hospital, Akasaka 3 52, Kashiwazaki 945 8585, Japan
    Arch Neurol 59:1804-8. 2002
    ..Patients with MJD usually present with cerebellar ataxia, external ophthalmoplegia, pyramidal and extrapyramidal signs, and muscle wasting. However, it has been reported that these patients do not demonstrate dementia...
  33. ncbi request reprint Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates
    Seong Hun Kim
    Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 278:33992-4002. 2003
    ....