Kazuhiro Furukawa

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. ncbi request reprint The binding of lamin B receptor to chromatin is regulated by phosphorylation in the RS region
    Makoto Takano
    Course of Biosphere Science, Graduate School of Science and Technology, Niigata University, Japan
    Eur J Biochem 269:943-53. 2002
  2. ncbi request reprint [Nuclear envelopathies]
    Kazuhiro Furukawa
    Tanpakushitsu Kakusan Koso 51:2263-8. 2006
  3. doi request reprint A-type and B-type lamins initiate layer assembly at distinct areas of the nuclear envelope in living cells
    Kazuhiro Furukawa
    Department of Chemistry, Faculty of Science, Niigata University, Niigata 950 2181, Japan
    Exp Cell Res 315:1181-9. 2009
  4. ncbi request reprint Barrier-to-autointegration factor plays crucial roles in cell cycle progression and nuclear organization in Drosophila
    Kazuhiro Furukawa
    Department of Chemistry, Faculty of Science, Niigata University, Niigata 950 2181, Japan
    J Cell Sci 116:3811-23. 2003
  5. ncbi request reprint BAF as a caspase-dependent mediator of nuclear apoptosis in Drosophila
    Kazuhiro Furukawa
    Department of Chemistry, Faculty of Science, Niigata University, Niigata 950 2181, Japan
    J Struct Biol 160:125-34. 2007
  6. ncbi request reprint Nuclear envelope precursor vesicle targeting to chromatin is stimulated by protein phosphatase 1 in Xenopus egg extracts
    Hiromi Ito
    Courses of Fundamental Sciences, Graduate School of Science and Technology, Niigata University, Igarashi 2, Niigata 950 2181, Japan
    Exp Cell Res 313:1897-910. 2007
  7. ncbi request reprint Regulation of binding of lamin B receptor to chromatin by SR protein kinase and cdc2 kinase in Xenopus egg extracts
    Makoto Takano
    Course of Biosphere Science, Graduate School of Science and Technology, Faculty of Science, Niigata University, Igarashi 2, Niigata 950 2181, Japan
    J Biol Chem 279:13265-71. 2004
  8. ncbi request reprint Null mutants of Drosophila B-type lamin Dm(0) show aberrant tissue differentiation rather than obvious nuclear shape distortion or specific defects during cell proliferation
    Shinichi Osouda
    Department of Chemistry, Faculty of Science, Niigata University, Niigata 950 2181, Japan
    Dev Biol 284:219-32. 2005
  9. doi request reprint Purification and proteomic analysis of a nuclear-insoluble protein fraction
    Tsuneyoshi Horigome
    Department of Chemistry, Faculty of Science, Niigata University, Niigata, Japan
    Methods Mol Biol 432:139-48. 2008
  10. doi request reprint Nuclear matrix contains novel WD-repeat and disordered-region-rich proteins
    Kohei Ishii
    Graduate School of Science and Technology, Niigata University, Igarashi 2, Nishi ku, Niigata 950 2181, Japan
    FEBS Lett 582:3515-9. 2008

Collaborators

Detail Information

Publications20

  1. ncbi request reprint The binding of lamin B receptor to chromatin is regulated by phosphorylation in the RS region
    Makoto Takano
    Course of Biosphere Science, Graduate School of Science and Technology, Niigata University, Japan
    Eur J Biochem 269:943-53. 2002
    ..These results suggested that the cell cycle-dependent binding of LBR to chromatin is regulated by phosphorylation in the arginine-serine repeat-containing region by multiple kinases...
  2. ncbi request reprint [Nuclear envelopathies]
    Kazuhiro Furukawa
    Tanpakushitsu Kakusan Koso 51:2263-8. 2006
  3. doi request reprint A-type and B-type lamins initiate layer assembly at distinct areas of the nuclear envelope in living cells
    Kazuhiro Furukawa
    Department of Chemistry, Faculty of Science, Niigata University, Niigata 950 2181, Japan
    Exp Cell Res 315:1181-9. 2009
    ..This previously unknown complexity in the assembly of the nuclear lamina could be the basis for intricate nuclear envelope functions...
  4. ncbi request reprint Barrier-to-autointegration factor plays crucial roles in cell cycle progression and nuclear organization in Drosophila
    Kazuhiro Furukawa
    Department of Chemistry, Faculty of Science, Niigata University, Niigata 950 2181, Japan
    J Cell Sci 116:3811-23. 2003
    ..We thus conclude that BAF plays essential roles in nuclear organization and that these BAF functions are required in both M phase and interphase of the cell cycle...
  5. ncbi request reprint BAF as a caspase-dependent mediator of nuclear apoptosis in Drosophila
    Kazuhiro Furukawa
    Department of Chemistry, Faculty of Science, Niigata University, Niigata 950 2181, Japan
    J Struct Biol 160:125-34. 2007
    ..In summary, BAF disappears at an early stage due to caspase activity when apoptosis is induced by hid, and its depletion in mutants is sufficient in itself to induce cell death, suggesting it is an apoptotic mediator...
  6. ncbi request reprint Nuclear envelope precursor vesicle targeting to chromatin is stimulated by protein phosphatase 1 in Xenopus egg extracts
    Hiromi Ito
    Courses of Fundamental Sciences, Graduate School of Science and Technology, Niigata University, Igarashi 2, Niigata 950 2181, Japan
    Exp Cell Res 313:1897-910. 2007
    ..A possible mechanism involving PP1 and LBR for the regulation of nuclear membrane targeting to chromatin was discussed...
  7. ncbi request reprint Regulation of binding of lamin B receptor to chromatin by SR protein kinase and cdc2 kinase in Xenopus egg extracts
    Makoto Takano
    Course of Biosphere Science, Graduate School of Science and Technology, Faculty of Science, Niigata University, Igarashi 2, Niigata 950 2181, Japan
    J Biol Chem 279:13265-71. 2004
    ..Experiments involving a mutant NK fragment showed that the phosphorylation of serine 71 by cdc2 kinase is responsible for the suppression...
  8. ncbi request reprint Null mutants of Drosophila B-type lamin Dm(0) show aberrant tissue differentiation rather than obvious nuclear shape distortion or specific defects during cell proliferation
    Shinichi Osouda
    Department of Chemistry, Faculty of Science, Niigata University, Niigata 950 2181, Japan
    Dev Biol 284:219-32. 2005
    ..In contrast, both gonadal and CNS tissues exhibited underdevelopment...
  9. doi request reprint Purification and proteomic analysis of a nuclear-insoluble protein fraction
    Tsuneyoshi Horigome
    Department of Chemistry, Faculty of Science, Niigata University, Niigata, Japan
    Methods Mol Biol 432:139-48. 2008
    ..Using this protocol, 138 were separated, 29 were identified, among which one appears as a novel nuclear constituent localized in the interchromatin space...
  10. doi request reprint Nuclear matrix contains novel WD-repeat and disordered-region-rich proteins
    Kohei Ishii
    Graduate School of Science and Technology, Niigata University, Igarashi 2, Nishi ku, Niigata 950 2181, Japan
    FEBS Lett 582:3515-9. 2008
    ..Seven WD-repeat proteins and 16 disordered region-rich proteins, which act frequently as scaffolding proteins for macro-protein complexes, were found amongst the novel proteins...
  11. doi request reprint Loss of Drosophila A-type lamin C initially causes tendon abnormality including disintegration of cytoskeleton and nuclear lamina in muscular defects
    Ryo Uchino
    Department of Chemistry, Faculty of Science, Niigata University, Niigata 950 2181, Japan
    Dev Biol 373:216-27. 2013
    ..Thus the critical function of A-type lamin C proteins in Drosophila musculature is to maintain proper function and morphology of tendon cells...
  12. doi request reprint A fully automated phosphopeptide purification system for large-scale phosphoproteome analysis
    Yuka Iwase
    Graduate School of Science and Technology, Department of Chemistry, Faculty of Science, Niigata University, Igarashi 2, Nishi ku, Niigata 950 2181, Japan
    J Biochem 147:689-96. 2010
    ..e. a Xenopus egg cytosol fraction, without any pre-treatment...
  13. ncbi request reprint Proteome analysis of a rat liver nuclear insoluble protein fraction and localization of a novel protein, ISP36, to compartments in the interchromatin space
    Masashi Segawa
    Natural Science Course, Graduate School of Science and Technology, Niigata University, Japan
    FEBS J 272:4327-38. 2005
    ..The protein was designated 'interchromatin space protein of 36 kDa', ISP36...
  14. ncbi request reprint [Proteomic analyses of nuclei]
    Tsuneyoshi Horigome
    Tanpakushitsu Kakusan Koso 51:2013-9. 2006
  15. ncbi request reprint Participation of a fusogenic protein, glyceraldehyde-3-phosphate dehydrogenase, in nuclear membrane assembly
    Tomoaki Nakagawa
    Course of Functional Biology, Graduate School of Science and Technology, Niigata University, Igarashi 2, Japan
    J Biol Chem 278:20395-404. 2003
    ..We propose that GAPDH plays a crucial role in the membrane fusion step in nuclear assembly in a Xenopus egg extract cell-free system...
  16. ncbi request reprint Dissociation of emerin from barrier-to-autointegration factor is regulated through mitotic phosphorylation of emerin in a xenopus egg cell-free system
    Yasuhiro Hirano
    Graduate School of Biostudies, Kyoto University, Kitashirakawa ohiwakecho, Sakyo ku, Kyoto 606 8205, Japan
    J Biol Chem 280:39925-33. 2005
    ..An in vitro binding assay involving an emerin S175A point mutant protein suggested that phosphorylation at Ser175 regulates the dissociation of emerin from BAF...
  17. ncbi request reprint LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly
    Thomas Dechat
    Max F Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Medical Biochemistry, Medical University of Vienna, 1030 Vienna, Austria
    J Cell Sci 117:6117-28. 2004
    ..We propose that LAP2alpha and a subfraction of BAF form defined complexes in chromatin core regions and may be involved in chromatin reorganization during early stages of nuclear assembly...
  18. pmc HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication
    Sandra Martins
    Institute of Medical Biochemistry, University of Oslo, Oslo 0317, Norway
    J Cell Biol 160:177-88. 2003
    ..Rescue of Cdc6 degradation with proteasome inhibitors restores replication. We propose that an interaction of LAP2beta, or LAP2 proteins, with HA95 is involved in the control of initiation of DNA replication...
  19. ncbi request reprint [Nuclear membrane and nuclear lamina]
    Kazuhiro Furukawa
    Tanpakushitsu Kakusan Koso 51:1931-6. 2006
  20. ncbi request reprint Rapid DNA chemical ligation for amplification of RNA and DNA signal
    Hiroshi Abe
    Nano Medical Engineering Laboratory, Discovery Research Institute, RIKEN, 2 1, Hirosawa, Wako Shi, Saitama, 351 0198 Japan
    Bioconjug Chem 19:327-33. 2008
    ..The reaction also exhibits a significant level of signal amplification under thermal cycling in periods as short as 100-120 min, with the RNA or DNA target acting in a catalytic way to ligate multiple pairs of probes...