Research Topics
Genomes and Genes | Kazuhiro FurukawaSummaryAffiliation: Niigata University Country: Japan Publications
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Detail Information
Publications
The binding of lamin B receptor to chromatin is regulated by phosphorylation in the RS regionMakoto Takano
Course of Biosphere Science, Graduate School of Science and Technology, Niigata University, Japan
Eur J Biochem 269:943-53. 2002..These results suggested that the cell cycle-dependent binding of LBR to chromatin is regulated by phosphorylation in the arginine-serine repeat-containing region by multiple kinases...- [Nuclear envelopathies]Kazuhiro Furukawa
Tanpakushitsu Kakusan Koso 51:2263-8. 2006 
A-type and B-type lamins initiate layer assembly at distinct areas of the nuclear envelope in living cellsKazuhiro Furukawa
Department of Chemistry, Faculty of Science, Niigata University, Niigata 950 2181, Japan
Exp Cell Res 315:1181-9. 2009..This previously unknown complexity in the assembly of the nuclear lamina could be the basis for intricate nuclear envelope functions...- Barrier-to-autointegration factor plays crucial roles in cell cycle progression and nuclear organization in DrosophilaKazuhiro Furukawa
Department of Chemistry, Faculty of Science, Niigata University, Niigata 950 2181, Japan
J Cell Sci 116:3811-23. 2003..We thus conclude that BAF plays essential roles in nuclear organization and that these BAF functions are required in both M phase and interphase of the cell cycle... - BAF as a caspase-dependent mediator of nuclear apoptosis in DrosophilaKazuhiro Furukawa
Department of Chemistry, Faculty of Science, Niigata University, Niigata 950 2181, Japan
J Struct Biol 160:125-34. 2007..In summary, BAF disappears at an early stage due to caspase activity when apoptosis is induced by hid, and its depletion in mutants is sufficient in itself to induce cell death, suggesting it is an apoptotic mediator... - Nuclear envelope precursor vesicle targeting to chromatin is stimulated by protein phosphatase 1 in Xenopus egg extractsHiromi Ito
Courses of Fundamental Sciences, Graduate School of Science and Technology, Niigata University, Igarashi 2, Niigata 950 2181, Japan
Exp Cell Res 313:1897-910. 2007..A possible mechanism involving PP1 and LBR for the regulation of nuclear membrane targeting to chromatin was discussed... - Regulation of binding of lamin B receptor to chromatin by SR protein kinase and cdc2 kinase in Xenopus egg extractsMakoto Takano
Course of Biosphere Science, Graduate School of Science and Technology, Faculty of Science, Niigata University, Igarashi 2, Niigata 950 2181, Japan
J Biol Chem 279:13265-71. 2004..Experiments involving a mutant NK fragment showed that the phosphorylation of serine 71 by cdc2 kinase is responsible for the suppression... - Null mutants of Drosophila B-type lamin Dm(0) show aberrant tissue differentiation rather than obvious nuclear shape distortion or specific defects during cell proliferationShinichi Osouda
Department of Chemistry, Faculty of Science, Niigata University, Niigata 950 2181, Japan
Dev Biol 284:219-32. 2005..In contrast, both gonadal and CNS tissues exhibited underdevelopment... - Purification and proteomic analysis of a nuclear-insoluble protein fractionTsuneyoshi Horigome
Department of Chemistry, Faculty of Science, Niigata University, Niigata, Japan
Methods Mol Biol 432:139-48. 2008..Using this protocol, 138 were separated, 29 were identified, among which one appears as a novel nuclear constituent localized in the interchromatin space... - Nuclear matrix contains novel WD-repeat and disordered-region-rich proteinsKohei Ishii
Graduate School of Science and Technology, Niigata University, Igarashi 2, Nishi ku, Niigata 950 2181, Japan
FEBS Lett 582:3515-9. 2008..Seven WD-repeat proteins and 16 disordered region-rich proteins, which act frequently as scaffolding proteins for macro-protein complexes, were found amongst the novel proteins... - A fully automated phosphopeptide purification system for large-scale phosphoproteome analysisYuka Iwase
Graduate School of Science and Technology, Department of Chemistry, Faculty of Science, Niigata University, Igarashi 2, Nishi ku, Niigata 950 2181, Japan
J Biochem 147:689-96. 2010..e. a Xenopus egg cytosol fraction, without any pre-treatment... - Loss of Drosophila A-type lamin C initially causes tendon abnormality including disintegration of cytoskeleton and nuclear lamina in muscular defectsRyo Uchino
Department of Chemistry, Faculty of Science, Niigata University, Niigata 950 2181, Japan
Dev Biol 373:216-27. 2013..Thus the critical function of A-type lamin C proteins in Drosophila musculature is to maintain proper function and morphology of tendon cells... - Proteome analysis of a rat liver nuclear insoluble protein fraction and localization of a novel protein, ISP36, to compartments in the interchromatin spaceMasashi Segawa
Natural Science Course, Graduate School of Science and Technology, Niigata University, Japan
FEBS J 272:4327-38. 2005..The protein was designated 'interchromatin space protein of 36 kDa', ISP36... - [Proteomic analyses of nuclei]Tsuneyoshi Horigome
Tanpakushitsu Kakusan Koso 51:2013-9. 2006 - Participation of a fusogenic protein, glyceraldehyde-3-phosphate dehydrogenase, in nuclear membrane assemblyTomoaki Nakagawa
Course of Functional Biology, Graduate School of Science and Technology, Niigata University, Igarashi 2, Japan
J Biol Chem 278:20395-404. 2003..We propose that GAPDH plays a crucial role in the membrane fusion step in nuclear assembly in a Xenopus egg extract cell-free system... - Dissociation of emerin from barrier-to-autointegration factor is regulated through mitotic phosphorylation of emerin in a xenopus egg cell-free systemYasuhiro Hirano
Graduate School of Biostudies, Kyoto University, Kitashirakawa ohiwakecho, Sakyo ku, Kyoto 606 8205, Japan
J Biol Chem 280:39925-33. 2005..An in vitro binding assay involving an emerin S175A point mutant protein suggested that phosphorylation at Ser175 regulates the dissociation of emerin from BAF... - LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assemblyThomas Dechat
Max F Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Medical Biochemistry, Medical University of Vienna, 1030 Vienna, Austria
J Cell Sci 117:6117-28. 2004..We propose that LAP2alpha and a subfraction of BAF form defined complexes in chromatin core regions and may be involved in chromatin reorganization during early stages of nuclear assembly... 
HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replicationSandra Martins
Institute of Medical Biochemistry, University of Oslo, Oslo 0317, Norway
J Cell Biol 160:177-88. 2003..Rescue of Cdc6 degradation with proteasome inhibitors restores replication. We propose that an interaction of LAP2beta, or LAP2 proteins, with HA95 is involved in the control of initiation of DNA replication...- [Nuclear membrane and nuclear lamina]Kazuhiro Furukawa
Tanpakushitsu Kakusan Koso 51:1931-6. 2006 - Rapid DNA chemical ligation for amplification of RNA and DNA signalHiroshi Abe
Nano Medical Engineering Laboratory, Discovery Research Institute, RIKEN, 2 1, Hirosawa, Wako Shi, Saitama, 351 0198 Japan
Bioconjug Chem 19:327-33. 2008..The reaction also exhibits a significant level of signal amplification under thermal cycling in periods as short as 100-120 min, with the RNA or DNA target acting in a catalytic way to ligate multiple pairs of probes...