Takashi Asada

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. ncbi Efficacy of milnacipran on the depressive state in patients with Alzheimer's disease
    Katsuyoshi Mizukami
    Department of Psychiatry, Institute of Clinical Medicine University of Tsukuba, Japan, 1 1 1Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1342-6. 2006
  2. ncbi [Concept of cognition rehabilitation in Alzheimer disease and a preliminary trial]
    Takashi Asada
    Seishin Shinkeigaku Zasshi 107:1310-3. 2005
  3. ncbi Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease
    Ryozo Kuwano
    Genome Science Branch, Center for Bioresource based Researches, Brain Research Institute, Niigata University, Niigata, Japan
    Hum Mol Genet 15:2170-82. 2006
  4. pmc GAB2 is not associated with late-onset Alzheimer's disease in Japanese
    Akinori Miyashita
    Department of Molecular Genetics, Bioresource Science Branch, Center for Bioresources, Brain Research Institute, Niigata University, Niigata, Japan
    Eur J Hum Genet 17:682-6. 2009
  5. ncbi Genetic association of CTNNA3 with late-onset Alzheimer's disease in females
    Akinori Miyashita
    Center for Bioresources, Brain Research Institute, Niigata University, Niigata, Japan
    Hum Mol Genet 16:2854-69. 2007
  6. pmc SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians
    Akinori Miyashita
    Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan
    PLoS ONE 8:e58618. 2013
  7. doi Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese
    Norihiro Takei
    Department of Molecular Genetics, Bioresource Science Branch, Center for Bioresources, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    Genomics 93:441-8. 2009
  8. ncbi Association between tau polymorphism and male early-onset Alzheimer's disease
    Hiroshi Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neuroreport 15:175-9. 2004
  9. ncbi Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population
    Yoshiko Tamura
    National Center of Neurology and Psychiatry, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurosci Lett 379:149-51. 2005
  10. ncbi Genetic and expression analyses of FZD3 in schizophrenia
    Masayuki Ide
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako City, Saitama, Japan
    Biol Psychiatry 56:462-5. 2004

Collaborators

Detail Information

Publications47

  1. ncbi Efficacy of milnacipran on the depressive state in patients with Alzheimer's disease
    Katsuyoshi Mizukami
    Department of Psychiatry, Institute of Clinical Medicine University of Tsukuba, Japan, 1 1 1Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1342-6. 2006
    ..In addition, the treatment had no negative effects on cognitive function of the patients. Our study results suggest that milnacipran is a promising medicine for depressive state in AD patients...
  2. ncbi [Concept of cognition rehabilitation in Alzheimer disease and a preliminary trial]
    Takashi Asada
    Seishin Shinkeigaku Zasshi 107:1310-3. 2005
  3. ncbi Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease
    Ryozo Kuwano
    Genome Science Branch, Center for Bioresource based Researches, Brain Research Institute, Niigata University, Niigata, Japan
    Hum Mol Genet 15:2170-82. 2006
    ..0169). Thus, we confirmed the association of DNMBP with AD individuals with the APOE-epsilon3*3 genotype or lacking the epsilon4 allele, and DNMBP may be one of the susceptibility genes for AD...
  4. pmc GAB2 is not associated with late-onset Alzheimer's disease in Japanese
    Akinori Miyashita
    Department of Molecular Genetics, Bioresource Science Branch, Center for Bioresources, Brain Research Institute, Niigata University, Niigata, Japan
    Eur J Hum Genet 17:682-6. 2009
    ..Here, we attempted to replicate the finding by genotyping these SNPs in a large clinical cohort of Japanese. We observed no association of any of the SNPs with LOAD. GAB2 may not be a disease susceptibility gene for LOAD in Japanese...
  5. ncbi Genetic association of CTNNA3 with late-onset Alzheimer's disease in females
    Akinori Miyashita
    Center for Bioresources, Brain Research Institute, Niigata University, Niigata, Japan
    Hum Mol Genet 16:2854-69. 2007
    ..Furthermore, we found that this SNP exhibited no interaction with the APOE-epsilon4 allele. Our data suggest that CTNNA3 may affect LOAD through a female-specific mechanism independent of the APOE-epsilon4 allele...
  6. pmc SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians
    Akinori Miyashita
    Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan
    PLoS ONE 8:e58618. 2013
    ..Our study highlights the importance of examining associations in multiple ethnic populations...
  7. doi Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese
    Norihiro Takei
    Department of Molecular Genetics, Bioresource Science Branch, Center for Bioresources, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    Genomics 93:441-8. 2009
    ..Strong LD between these SNPs was observed (mean |D'|=0.914). These data suggest that the three genes other than APOE, i.e. PVRL2, TOMM40 and APOC1, could also yield a predisposition to LOAD...
  8. ncbi Association between tau polymorphism and male early-onset Alzheimer's disease
    Hiroshi Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neuroreport 15:175-9. 2004
    ..30-5.42), suggesting that age and gender modify the risk effect. However, we failed to replicate the reported association between the Saitohin gene located in the tau intron 9 and Japanese Alzheimer's disease...
  9. ncbi Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population
    Yoshiko Tamura
    National Center of Neurology and Psychiatry, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurosci Lett 379:149-51. 2005
    ..Therefore, the data presented here suggests that the CXCL1 gene could not be associated with the susceptibility to AD in a Japanese population...
  10. ncbi Genetic and expression analyses of FZD3 in schizophrenia
    Masayuki Ide
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako City, Saitama, Japan
    Biol Psychiatry 56:462-5. 2004
    ..Our study attempted to confirm associations between FZD3 and schizophrenia in Japanese family and case-control samples...
  11. ncbi Alcohol consumption and risk of dementia
    Noriko Tanaka
    Lancet 360:491. 2002
  12. ncbi Autotaxin expression is enhanced in frontal cortex of Alzheimer-type dementia patients
    Ken Umemura
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Neurosci Lett 400:97-100. 2006
    ..These observations suggest that expression of the autotaxin gene and cell signaling by lysophosphatidic acid may be involved in the pathology of ATD, and that this cell signaling pathway may be a potential target of treatments for ATD...
  13. ncbi Association of treatment-resistant schizophrenia with the G2677A/T and C3435T polymorphisms in the ATP-binding cassette subfamily B member 1 gene
    Tetsuya Takao
    Psychiatr Genet 16:47-8. 2006
  14. ncbi Lack of association between TrkA single nucleotide polymorphisms and sporadic Alzheimer's disease in a Japanese population
    Yuji Sakasegawa
    Department of Cortical Function Disorders, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187 8502, Japan
    Neurosci Lett 353:49-52. 2003
    ..Thus, the TrkA genotype does not appear to influence the risk of developing sporadic AD in a Japanese population...
  15. ncbi Absence of association between codon 129/219 polymorphisms of the prion protein gene and Alzheimer's disease in Japan
    Takuya Ohkubo
    Ann Neurol 54:553-4; author reply 555. 2003
  16. ncbi Apolipoprotein E genotype and early Alzheimer's disease: a longitudinal SPECT study
    Shigeki Sakamoto
    Department of Radiology, National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, 187 8551 Tokyo, Japan
    J Neuroimaging 13:113-23. 2003
    ..To determine the association of the apolipoprotein E (APOE) genotype and longitudinal changes of regional cerebral blood flow (rCBF) in Alzheimer's disease (AD). Previous reports have yielded conflicting results concerning this association...
  17. ncbi Log-linear models for assessing gene-age interaction and their application to case-control studies of the apolipoprotein E (apoE) gene in Alzheimer's disease
    Noriko Tanaka
    Department of Biostatistics, School of Health Sciences and Nursing, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Hum Genet 48:520-4. 2003
    ..We were able to derive an appropriate inference on whether the interaction was a gene-age interaction or merely a bias due to death from other diseases...
  18. ncbi Association analysis of an (AC)n repeat polymorphism in the GABA(B) receptor gene and schizophrenia
    Koubun Imai
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Am J Med Genet 114:605-8. 2002
    ..0015). These differences, however, were not significant after Bonferroni correction. These data did not support our hypothesis that polymorphisms of the GABA(B) receptor gene may confer vulnerability for schizophrenia...
  19. ncbi Brain SPET abnormalities in Alzheimer's disease before and after atrophy correction
    Hiroshi Matsuda
    Department of Radiology, National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, 187 8551, Tokyo, Japan
    Eur J Nucl Med Mol Imaging 29:1502-5. 2002
    ..This correction seems to be essential in order to achieve accurate measurements of rCBF in SPET, which has limited spatial resolution...
  20. ncbi [A 7-year follow-up study of cases with dementia to identify predictors of mortality]
    Takuro Motonaga
    Department of Psychology, Faculty of Letters, Teikyo University
    Nihon Koshu Eisei Zasshi 49:620-30. 2002
    ..To identify factors associated with mortality in cases with Alzheimer's disease (AD) and vascular dementia (VD), we conducted a seven-year follow-up study...
  21. ncbi A new EEG method for estimating cortical neuronal impairment that is sensitive to early stage Alzheimer's disease
    Toshimitsu Musha
    Brain Functions Laboratory Inc, KSP Building E211, Sakado, Takatsu Kawasaki, Kanagawa pref 213 0012, Japan
    Clin Neurophysiol 113:1052-8. 2002
    ..To test the hypothesis that elecetroencephalographic (EEG) analysis is sensitive to cortical neuronal impairment in early stage Alzheimer's disease (AD), and that this analysis correlates with corresponding changes in cerebral blood flow...
  22. ncbi Failure to support a genetic contribution of AKT1 polymorphisms and altered AKT signaling in schizophrenia
    Masayuki Ide
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    J Neurochem 99:277-87. 2006
    ..Collectively, this study failed to support reduced signaling of the AKT-GSK3beta molecular cascade in schizophrenia...
  23. ncbi [Cognitive disorders]
    Takashi Asada
    Seishin Shinkeigaku Zasshi 108:772-6. 2006
  24. ncbi MDR1 gene polymorphism in Japanese patients with schizophrenia and mood disorders including depression
    Wen Qian
    Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Biol Pharm Bull 29:2446-50. 2006
    ..These findings suggested that predispose to mood disorders, not schizophrenia, was associated with possible alteration of P-gp activities corresponding MDR1 polymorphism at least partly...
  25. ncbi Incidence of dementia and associated risk factors in Japan: The Osaki-Tajiri Project
    Kenichi Meguro
    Department of Geriatric Behavioral Neurology, Tohoku University Graduate School of Medicine, Japan
    J Neurol Sci 260:175-82. 2007
    ..A comprehensive system including CDR, cognitive tests, and MRI, is recommended in community-based health policy planning...
  26. ncbi Superiority of 3-dimensional stereotactic surface projection analysis over visual inspection in discrimination of patients with very early Alzheimer's disease from controls using brain perfusion SPECT
    Etsuko Imabayashi
    Department of Radiology, National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Nucl Med 45:1450-7. 2004
    ..We compared a 3-dimensional stereotactic surface projection (3D-SSP) technique with visual inspection in the discrimination of patients with very early AD from age-matched controls using brain perfusion SPECT...
  27. doi Cigarette smoking and risk of disabling dementia in a Japanese rural community: a nested case-control study
    Ai Ikeda
    Public Health, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
    Cerebrovasc Dis 25:324-31. 2008
    ..Previous prospective cohort studies have examined the association between smoking and the risk of dementia, but the results were inconsistent...
  28. doi Donepezil treatment of patients with severe Alzheimer's disease in a Japanese population: results from a 24-week, double-blind, placebo-controlled, randomized trial
    Akira Homma
    Dementia Interventional Research Group, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Dement Geriatr Cogn Disord 25:399-407. 2008
    ..A 24-week, randomized, parallel-group, double-blind placebo-controlled study was conducted to evaluate the efficacy and tolerability of donepezil in severe Alzheimer's disease (AD)...
  29. ncbi Brain hydrogen sulfide is severely decreased in Alzheimer's disease
    Ko Eto
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8551, Japan
    Biochem Biophys Res Commun 293:1485-8. 2002
    ..These observations suggest that CBS activity is reduced in AD brains and the decrease in H2S may be involved in some aspects of the cognitive decline in AD...
  30. ncbi c954C-->T polymorphism in the Fe65L2 gene is associated with early-onset Alzheimer's disease
    Hiroshi Tanahashi
    Ann Neurol 52:691-3. 2002
  31. ncbi Beneficial effects of perospirone on aggressive behavior associated with dementia
    Shinji Sato
    Department of Psychiatry, Tsukuba Memorial Hospital, Tsukuba, Japan
    Psychiatry Clin Neurosci 60:106-9. 2006
    ..This study suggests that perospirone is effective in improving aggressive and agitated behavioral symptoms in demented patients and is safe to use in elderly patients...
  32. ncbi Functional interactions between entorhinal cortex and posterior cingulate cortex at the very early stage of Alzheimer's disease using brain perfusion single-photon emission computed tomography
    Kentaro Hirao
    Department of Radiology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Tokyo, Japan
    Nucl Med Commun 27:151-6. 2006
    ..To test the hypothesis, we investigated the functional connectivity between the entorhinal cortex and posterior cingulate cortex...
  33. ncbi Effects of partial volume correction on discrimination between very early Alzheimer's dementia and controls using brain perfusion SPECT
    Hidekazu Kanetaka
    Department of Radiology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Eur J Nucl Med Mol Imaging 31:975-80. 2004
    ..9% to 83.7% with global mean normalization. The PVC mildly enhanced the accuracy from 73.1% to 76.3% with cerebellar normalization. This result suggests that early diagnosis of AD requires PVC in a SPECT study...
  34. ncbi [Non-pharmacological therapy for Alzheimer's disease]
    Takashi Asada
    Department of Neuropsychiatry, Institute of Clinical Medicine, University of Tsukuba
    Nihon Rinsho 62:72-5. 2004
  35. ncbi [Behave-AD]
    Takashi Asada
    Department of Neuropsychiatry, Institute of Clinical Medicine, University of Tsukuba
    Nihon Rinsho 62:31-8. 2004
  36. ncbi Longitudinal evaluation of both morphologic and functional changes in the same individuals with Alzheimer's disease
    Hiroshi Matsuda
    Department of Radiology, National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Nucl Med 43:304-11. 2002
    ..The aim of this study was to determine the initial abnormality and the longitudinal changes in both morphologic and functional measurements for the same individuals with AD...
  37. ncbi Clinical characteristics of Alzheimer's disease
    Takashi Asada
    Department of Neuropsychiatry, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki
    Intern Med 42:310-1. 2003
  38. ncbi Immunohistochemical study of hnRNP B1 in the postmortem temporal cortices of patients with Alzheimer's disease
    Masanori Ishikawa
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
    Neurosci Res 50:481-4. 2004
    ..Our study suggests that hnRNP B1-associated post-transcriptional regulations are preserved in the inferior temporal cortex of Alzheimer's disease...
  39. ncbi EEG filtering based on blind source separation (BSS) for early detection of Alzheimer's disease
    Andrzej Cichocki
    Laboratory for Advanced Brain Signal Processing, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Clin Neurophysiol 116:729-37. 2005
    ..The technique is based on filtering of EEG data using blind source separation (BSS) and projection of components which are possibly sensitive to cortical neuronal impairment found in early stages of AD...
  40. ncbi Changes in hippocampal GABABR1 subunit expression in Alzheimer's patients: association with Braak staging
    Masahiko Iwakiri
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, 305 8575, Tsukuba City, Ibaraki, Japan
    Acta Neuropathol 109:467-74. 2005
    ..Thus, changes in hippocampal GBR1 may reflect alterations in the balance between excitatory and inhibitory neurotransmitter systems, which likely contributes to dysfunction of hippocampal circuitry in AD...
  41. ncbi [Clinical course of Alzheimer disease]
    Takashi Asada
    Nihon Naika Gakkai Zasshi 91:144-7. 2002
  42. ncbi Voxel-based morphometry to discriminate early Alzheimer's disease from controls
    Yoko Hirata
    Department of Radiology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8551, Japan
    Neurosci Lett 382:269-74. 2005
    ..8%. This result would open up a possibility for early diagnosis of AD using VBM...
  43. ncbi Immunohistochemical study of the hnRNP A2 and B1 in the hippocampal formations of brains with Alzheimer's disease
    Katsuyoshi Mizukami
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki 305 8575, Japan
    Neurosci Lett 386:111-5. 2005
    ..Our study suggests that hnRNP A2 and B1 display different responses in the AD hippocampus, and further suggests that the post-transcriptional regulation is disturbed in neurons of the AD hippocampus...
  44. ncbi Genetic association analyses of PHOX2B and ASCL1 in neuropsychiatric disorders: evidence for association of ASCL1 with Parkinson's disease
    Masayuki Ide
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    Hum Genet 117:520-7. 2005
    ..The present genetic data may thus suggest that polyglutamine length polymorphisms in ASCL1 could influence predispositions to PD through the fine-tuning of LC integrity...
  45. ncbi The prediction of rapid conversion to Alzheimer's disease in mild cognitive impairment using regional cerebral blood flow SPECT
    Kentaro Hirao
    Department of Radiology, National Center Hospital of Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry, Tokyo, Japan
    Neuroimage 28:1014-21. 2005
    ....
  46. pmc Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p
    Tadao Arinami
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki Ken, 305 8577, Japan
    Am J Hum Genet 77:937-44. 2005
    ....
  47. ncbi A preliminary open-label study of 5-HT1A partial agonist tandospirone for behavioural and psychological symptoms associated with dementia
    Shinji Sato
    Department of Psychiatry, Tsukuba Memorial Hospital, Tsukuba, Japan
    Int J Neuropsychopharmacol 10:281-3. 2007
    ..No patients experienced severe adverse effects. The results suggest that tandospirone was effective at improving BPSD symptoms and well-tolerated in elderly demented patients...