Yoshihiro Suzuki

Summary

Affiliation: Nihon University
Country: Japan

Publications

  1. doi The high-affinity immunoglobulin E receptor (FcepsilonRI) regulates mitochondrial calcium uptake and a dihydropyridine receptor-mediated calcium influx in mast cells: Role of the FcepsilonRIbeta chain immunoreceptor tyrosine-based activation motif
    Yoshihiro Suzuki
    Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Sciences, 30 1 Oyaguchikami cho Itabashi ku, Tokyo 173 8610, Japan
    Biochem Pharmacol 75:1492-503. 2008
  2. doi L-type Ca2+ channels: a new player in the regulation of Ca2+ signaling, cell activation and cell survival in immune cells
    Yoshihiro Suzuki
    Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Science, 30 1 Oyaguchikami cho Itabashi ku, Tokyo 173 8610, Japan
    Mol Immunol 47:640-8. 2010
  3. ncbi Analysis of the mechanism for the development of allergic skin inflammation and the application for its treatment: aspirin modulation of IgE-dependent mast cell activation: role of aspirin-induced exacerbation of immediate allergy
    Yoshihiro Suzuki
    Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Science, Japan
    J Pharmacol Sci 110:237-44. 2009
  4. ncbi Exposure of RBL-2H3 mast cells to Ag(+) induces cell degranulation and mediator release
    Y Suzuki
    Department of Immunology and Microbiology, Nihon University School of Medicine, Tokyo, 173 8610, Japan
    Biochem Biophys Res Commun 283:707-14. 2001
  5. doi Ca v 1.2 L-type Ca2+ channel protects mast cells against activation-induced cell death by preventing mitochondrial integrity disruption
    Yoshihiro Suzuki
    Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Science, Tokyo, Japan
    Mol Immunol 46:2370-80. 2009
  6. ncbi Silver activates calcium signals in rat basophilic leukemia-2H3 mast cells by a mechanism that differs from the Fc epsilon RI-activated response
    Yoshihiro Suzuki
    Department of Immunology and Microbiology, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan
    J Immunol 169:3954-62. 2002
  7. ncbi Fc epsilon RI signaling of mast cells activates intracellular production of hydrogen peroxide: role in the regulation of calcium signals
    Yoshihiro Suzuki
    Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Sciences, Tokyo, Japan
    J Immunol 171:6119-27. 2003
  8. doi Endothelial nitric oxide synthase is essential for nitric oxide generation, L-type Ca2+ channel activation and survival in RBL-2H3 mast cells
    Yoshihiro Suzuki
    Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Science, 30 1 Oyaguchikami cho Itabashi ku, Tokyo 173 8610, Japan
    Biochim Biophys Acta 1803:372-85. 2010
  9. ncbi Role of oxidants in mast cell activation
    Yoshihiro Suzuki
    Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Sciences, Tokyo, Japan
    Chem Immunol Allergy 87:32-42. 2005
  10. doi Galectin-3 but not galectin-1 induces mast cell death by oxidative stress and mitochondrial permeability transition
    Yoshihiro Suzuki
    Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Sciences, Tokyo, Japan
    Biochim Biophys Acta 1783:924-34. 2008

Collaborators

Detail Information

Publications66

  1. doi The high-affinity immunoglobulin E receptor (FcepsilonRI) regulates mitochondrial calcium uptake and a dihydropyridine receptor-mediated calcium influx in mast cells: Role of the FcepsilonRIbeta chain immunoreceptor tyrosine-based activation motif
    Yoshihiro Suzuki
    Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Sciences, 30 1 Oyaguchikami cho Itabashi ku, Tokyo 173 8610, Japan
    Biochem Pharmacol 75:1492-503. 2008
    ..These data demonstrate that the FcepsilonRIbeta regulates [Ca2+]m uptake in mast cells via the ITAM and suggest that this plays a key role in regulating calcium influx especially that induced via a DHPR-mediated calcium channel...
  2. doi L-type Ca2+ channels: a new player in the regulation of Ca2+ signaling, cell activation and cell survival in immune cells
    Yoshihiro Suzuki
    Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Science, 30 1 Oyaguchikami cho Itabashi ku, Tokyo 173 8610, Japan
    Mol Immunol 47:640-8. 2010
    ..In this article, we review recent advances in our understanding of Ca(2+) signaling in immune cells with a special interest in mast cells. We highlight roles for LTCCs in antigen receptor-mediated mast cell activation and survival...
  3. ncbi Analysis of the mechanism for the development of allergic skin inflammation and the application for its treatment: aspirin modulation of IgE-dependent mast cell activation: role of aspirin-induced exacerbation of immediate allergy
    Yoshihiro Suzuki
    Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Science, Japan
    J Pharmacol Sci 110:237-44. 2009
    ..We also introduced our recent findings that mast cells express dihydropyridine-sensitive L-type Ca(2+) channels (LTCCs) and that Ca(2+) channels of this kind mediate aspirin modulation of LTC(4) secretion in mast cells...
  4. ncbi Exposure of RBL-2H3 mast cells to Ag(+) induces cell degranulation and mediator release
    Y Suzuki
    Department of Immunology and Microbiology, Nihon University School of Medicine, Tokyo, 173 8610, Japan
    Biochem Biophys Res Commun 283:707-14. 2001
    ..These results show that Ag(+) activates RBL-2H3 mast cells through a tyrosine phosphorylation-linked mechanism, which is distinct from that involved in FcepsilonRI-mediated activation...
  5. doi Ca v 1.2 L-type Ca2+ channel protects mast cells against activation-induced cell death by preventing mitochondrial integrity disruption
    Yoshihiro Suzuki
    Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Science, Tokyo, Japan
    Mol Immunol 46:2370-80. 2009
    ..These findings suggest that Ca(v)1.2 LTCC protects mast cells against activation-induced cell death by preventing mitochondrial integrity disruption...
  6. ncbi Silver activates calcium signals in rat basophilic leukemia-2H3 mast cells by a mechanism that differs from the Fc epsilon RI-activated response
    Yoshihiro Suzuki
    Department of Immunology and Microbiology, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan
    J Immunol 169:3954-62. 2002
    ..Our data strongly suggest the existence of an alternative pathway bypassing the early signaling events in mast cell activation and indicate that silver may be useful for analyses of such alternative mechanisms...
  7. ncbi Fc epsilon RI signaling of mast cells activates intracellular production of hydrogen peroxide: role in the regulation of calcium signals
    Yoshihiro Suzuki
    Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Sciences, Tokyo, Japan
    J Immunol 171:6119-27. 2003
    ..These studies demonstrate that activation of the intracellular oxidative burst is an important regulatory mechanism of mast cell responses...
  8. doi Endothelial nitric oxide synthase is essential for nitric oxide generation, L-type Ca2+ channel activation and survival in RBL-2H3 mast cells
    Yoshihiro Suzuki
    Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Science, 30 1 Oyaguchikami cho Itabashi ku, Tokyo 173 8610, Japan
    Biochim Biophys Acta 1803:372-85. 2010
    ..Taken together, the present findings demonstrate the key roles of the eNOS-NO-LTCC axis in mast cell survival after FcvarepsilonRI engagement...
  9. ncbi Role of oxidants in mast cell activation
    Yoshihiro Suzuki
    Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Sciences, Tokyo, Japan
    Chem Immunol Allergy 87:32-42. 2005
    ..This review summarizes current knowledge on the role of endogenous oxidants in mast cell activation...
  10. doi Galectin-3 but not galectin-1 induces mast cell death by oxidative stress and mitochondrial permeability transition
    Yoshihiro Suzuki
    Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Sciences, Tokyo, Japan
    Biochim Biophys Acta 1783:924-34. 2008
    ..These data suggest that galectin-3 induces oxidative stress, PTP opening, and the caspase-dependent death pathway by binding to putative surface receptors including RAGE via the carbohydrate recognition domain...
  11. doi Discrete generations of intracellular hydrogen peroxide and superoxide in antigen-stimulated mast cells: reciprocal regulation of store-operated Ca2+ channel activity
    Yoshihiro Suzuki
    Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Science, 30 1 Oyaguchikami cho Itabashi ku, Tokyo, Japan
    Mol Immunol 46:2200-9. 2009
    ..Such generations of multiple oxidant species and their distinct roles in the regulation of SOC activity may facilitate the fine tuning of Ca(2+) signaling in mast cells...
  12. ncbi Mitochondrial Ca2+ flux is a critical determinant of the Ca2+ dependence of mast cell degranulation
    Yoshihiro Suzuki
    Divisionof Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Sciences, 30 1 Oyaguchikami cho Itabashi ku, Tokyo 173 8610, Japan
    J Leukoc Biol 79:508-18. 2006
    ..This finding may shed light on a new role for mitochondria in the regulation of mast cell activation...
  13. ncbi Involvement of reactive oxygen species produced via NADPH oxidase in tyrosine phosphorylation in human B- and T-lineage lymphoid cells
    Y Suzuki
    Department of Microbiology, Nihon University School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 255:262-7. 1999
    ..Our results suggest a close link between ROS production and tyrosine phosphorylation induced by divergent extracellular stimuli and the possible role of NADPH oxidase or its related enzyme...
  14. ncbi Silver activates mast cells through reactive oxygen species production and a thiol-sensitive store-independent Ca2+ influx
    Tetsuro Yoshimaru
    Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Sciences, 30 1 Oyaguchikami cho, Itabashi ku, Tokyo 173 8610, Japan
    Free Radic Biol Med 40:1949-59. 2006
    ..Such a novel ROS-dependent pathway might play a role in mast cell degranulation in metal-induced allergic and autoimmune reactions...
  15. doi Extracellular superoxide released from mitochondria mediates mast cell death by advanced glycation end products
    Tetsuro Yoshimaru
    Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Sciences, 30 1 Oyaguchikami cho Itabashi ku, Tokyo 173 8610, Japan
    Biochim Biophys Acta 1783:2332-43. 2008
    ..AGE-induced mast cell apoptosis may contribute to the immunocompromised and inflammatory conditions...
  16. ncbi Fungal metabolite gliotoxin blocks mast cell activation by a calcium- and superoxide-dependent mechanism: implications for immunosuppressive activities
    Osamu Niide
    Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Sciences, 30 1 Oyaguchikami cho Itabashi ku, Tokyo 173 8610, Japan
    Clin Immunol 118:108-16. 2006
    ..These findings suggest that suppression of mast cell activation might contribute to the establishment of infections with gliotoxin-producing fungi...
  17. ncbi Positive and negative regulation of high affinity IgE receptor signaling by Src homology region 2 domain-containing phosphatase 1
    Kazuko Nakata
    Department of Immunology and Signal Transduction, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Science, Fuchu, Tokyo, Japan
    J Immunol 181:5414-24. 2008
    ....
  18. doi SHP-1 exhibits a pro-apoptotic function in antigen-stimulated mast cells: positive regulation of mitochondrial death pathways and negative regulation of survival signaling pathways
    Toshio Inoue
    Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Science, 30 1 Oyaguchikami cho, Itabashi ku, Tokyo 173 8610, Japan
    Mol Immunol 47:222-32. 2009
    ..These findings suggest that SHP-1 positively regulates mitochondrial death pathways and negatively regulates pro-survival signaling pathways...
  19. doi Reactive oxygen species produced up- or downstream of calcium influx regulate proinflammatory mediator release from mast cells: role of NADPH oxidase and mitochondria
    Toshio Inoue
    Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Sciences, Tokyo, Japan
    Biochim Biophys Acta 1783:789-802. 2008
    ..These results suggest that ROS produced upstream of Ca(2+) influx by NADPH oxidase and downstream of Ca(2+) influx by the mitochondria regulate the proinflammatory response of mast cells...
  20. ncbi Role of the FcepsilonRI beta-chain ITAM as a signal regulator for mast cell activation with monomeric IgE
    Satoshi Nunomura
    Division of Molecular Cell Immunology and Allergology, Nihon University School of Medicine, Itabashi ku, Tokyo 173 8910, Japan
    Int Immunol 17:685-94. 2005
    ..These findings for the first time revealed the unique functions of the beta-chain ITAM in both chemical mediator release and cytokine production of mast cells upon monomeric IgE stimulation...
  21. doi L-type Ca2+ channels in mast cells: activation by membrane depolarization and distinct roles in regulating mediator release from store-operated Ca2+ channels
    Tetsuro Yoshimaru
    Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Science, 30 1 Oyaguchikami cho Itabashi ku, Tokyo 173 8610, Japan
    Mol Immunol 46:1267-77. 2009
    ..These results demonstrate that mast cells express LTCCs, which becomes activated by membrane depolarization to regulate cytosolic and mitochondrial Ca(2+), thereby controlling mast cell activation in a distinct manner from SOCs...
  22. doi Deficiency of SHP1 leads to sustained and increased ERK activation in mast cells, thereby inhibiting IL-3-dependent proliferation and cell death
    Kazuko Nakata
    Department of Immunology and Signal Transduction, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Science, Fuchu, Tokyo, Japan
    Mol Immunol 48:472-80. 2011
    ..Furthermore, our results indicate that ERK would act as a negative regulator for cell proliferation and induce apoptosis when its activity is highly increased...
  23. doi Ca2+-dependent mast cell death induced by Ag (I) via cardiolipin oxidation and ATP depletion
    Toshio Inoue
    Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Science, Tokyo, Japan
    J Leukoc Biol 86:167-79. 2009
    ..This necrotic cell death may play roles in Ag-induced inflammation and autoimmune disorders...
  24. doi Nitric Oxide positively regulates Ag (I)-induced Ca(2+) influx and mast cell activation: role of a Nitric Oxide Synthase-independent pathway
    Toshio Inoue
    Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Science, Oyaguchikamicho Itabashi ku, Tokyo, Japan
    J Leukoc Biol 86:1365-75. 2009
    ..These data show that NOS-independent NO regulates mast cell activation positively via a unique store-independent Ca(2+) influx pathway. The present findings suggest multiple sources and functions of NO in mast cell biology...
  25. doi Epigallocatechin-3-gallate induces cytokine production in mast cells by stimulating an extracellular superoxide-mediated calcium influx
    Toshio Inoue
    Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Science, Tokyo, Japan
    Biochem Pharmacol 82:1930-9. 2011
    ..EGCG can serve as a powerful tool for studying O(2)(ยท-)-regulated Ca(2+) channels, which may be selectively involved in the regulation of cytokine production but have yet to be elucidated...
  26. ncbi Autoimmunity-inducing metals (Hg, Au and Ag) modulate mast cell signaling, function and survival
    Yoshihiro Suzuki
    Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Science, 30 1 Oyaguchikami cho Itabashi ku, Tokyo, Japan
    Curr Pharm Des 17:3805-14. 2011
    ..In this review, we provide an overview of recent advances in our understanding of the impacts of the three metals on mast cell signaling, function and survival and their possible roles in the pathologies of metal-induced autoimmunity...
  27. doi Nitric oxide protects mast cells from activation-induced cell death: the role of the phosphatidylinositol-3 kinase-Akt-endothelial nitric oxide synthase pathway
    Toshio Inoue
    Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Sciences, 30 1 Oyaguchikami cho Itabashi ku, Tokyo 173 8610, Japan
    J Leukoc Biol 83:1218-29. 2008
    ..The data suggest that the NO produced by the PI-3K-Akt-eNOS pathway is involved in protecting mast cells from cell death...
  28. doi Aspirin and salicylates modulate IgE-mediated leukotriene secretion in mast cells through a dihydropyridine receptor-mediated Ca(2+) influx
    Kana Togo
    Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Sciences, Itabashi ku, Tokyo, Japan
    Clin Immunol 131:145-56. 2009
    ..Instead, aspirin facilitated a dihydropyridine receptor-mediated Ca(2+) influx, resulting in increased LTC(4) secretion. This novel action of aspirin may play roles in exacerbation of immediate allergy and aspirin intolerance...
  29. doi Calcium signaling in mast cells: focusing on L-type calcium channels
    Yoshihiro Suzuki
    Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Science, 30 1 Oyaguchikami cho Itabashi ku, Tokyo 173 8610, Japan
    Adv Exp Med Biol 740:955-77. 2012
    ..In this chapter, we provide an overview of recent advances in our understanding of Ca(2+) signaling in mast cells with a special attention to the emerging role for the L-type Ca(2+) channels as a regulator of mast cell survival...
  30. doi Gold activates mast cells via calcium influx through multiple H2O2-sensitive pathways including L-type calcium channels
    Koremasa Hayama
    Division of Molecular Cell Immunology and Allergology, Graduate School of Medical Science, Nihon University, and Department of Dermatology, Nihon University Surugadai Hospital, Tokyo 173 8610, Japan
    Free Radic Biol Med 50:1417-28. 2011
    ..These findings provide insight into the roles of these Ca2+ channels in the Th2-independent process of gold-induced immunological disorders...
  31. doi Epigallocatechin-3-gallate inhibits mast cell degranulation, leukotriene C4 secretion, and calcium influx via mitochondrial calcium dysfunction
    Toshio Inoue
    Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Sciences, Tokyo, Japan
    Free Radic Biol Med 49:632-40. 2010
    ..These events may lead to [Ca(2+)](m) dysfunction and impair mitochondria-mediated facilitation of SOCE, thereby attenuating mast cell activation...
  32. pmc Depolarization potentiates TRAIL-induced apoptosis in human melanoma cells: role for ATP-sensitive K+ channels and endoplasmic reticulum stress
    Yoshihiro Suzuki
    Nihon University Graduate School of Medical Science, Tokyo, Japan
    Int J Oncol 41:465-75. 2012
    ..Thus, membrane-depolarizing agents such as KATP channel inhibitors may have therapeutic potential in the treatment of TRAIL-resistant cancer cells without impairing tumor-selectivity...
  33. ncbi Natural history of extensive Mongolian spots in mucopolysaccharidosis type II (Hunter syndrome): a survey among 52 Japanese patients
    T Ochiai
    Department of Dermatology, Surugadai Nihon University Hospital, Tokyo, Japan
    J Eur Acad Dermatol Venereol 21:1082-5. 2007
    ..However, a statistical survey of the incidence and natural history of extensive Mongolian spots among the patients with Hunter syndrome is lacking...
  34. ncbi Blockade of superoxide generation prevents high-affinity immunoglobulin E receptor-mediated release of allergic mediators by rat mast cell line and human basophils
    T Yoshimaru
    Department of Immunology and Microbiology, Nihon University School of Medicine, Tokyo, Japan
    Clin Exp Allergy 32:612-8. 2002
    ..However, the physiological significance of the burst of ROS is poorly understood...
  35. ncbi Possible involvement of mast cells in renal fibrosis in patients with IgA nephropathy
    T Sakamoto-Ihara
    Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    Inflamm Res 56:421-7. 2007
    ....
  36. ncbi Incidence of the appearance of the red color sign on esophageal varices and its predictive factors: long-term observations of 359 patients with cirrhosis
    N Murachima
    Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan
    J Gastroenterol 36:368-74. 2001
    ..001), size of varices (P = 0.027), and platelet count (P = 0.0315). CONCLUSIONS: Endoscopic signs of esophageal varices and platelet count were significant predictors for the appearance of the red color sign...
  37. pmc Primary human immunodeficiency virus type 1 viremia and central nervous system invasion in a novel hu-PBL-immunodeficient mouse strain
    Y Koyanagi
    Department of Microbiology, Tokyo Medical and Dental University, Bunkyo ku, Japan
    J Virol 71:2417-24. 1997
    ..The hu-PBL-NOD-scid mouse represents a useful model for the study of the pathogenesis of HIV-1 in vivo, especially brain involvement, and therapy of primary HIV-1 viremia...
  38. ncbi Antibody-forming cells in the nasal-associated lymphoid tissue during primary influenza virus infection
    S Tamura
    Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
    J Gen Virol 79:291-9. 1998
    ..These results suggest that virus-specific IgA antibodies, produced by IgA AFCs in NALT, play an important role in recovery from infection...
  39. ncbi Differential effects of protein tyrosine kinase inhibitors on interferon-gamma-induction of major histocompatibility complex class II and intercellular adhesion molecule-1 expression in human corneal epithelial cells
    M Iwata
    Department of Ophthalmology, Nihon University School of Medicine, Tokyo, Japan
    Jpn J Ophthalmol 45:13-21. 2001
    ....
  40. pmc Intercellular adhesion molecule-1 expression on human corneal epithelial outgrowth from limbal explant in culture
    M Iwata
    Department of Ophthalmology, Nihon University School of Medicine, Tokyo, Japan
    Br J Ophthalmol 87:203-7. 2003
    ..To investigate the relation between intercellular adhesion molecule (ICAM)-1 expression and cellular dynamics occurring concomitantly with epithelial cell movement...
  41. ncbi An increase in multi-drug-resistant isolates of Salmonella typhimurium from healty carriers in Aichi, Japan
    M Matsumoto
    Department of Microbiology, Aichi Prefectural Institute of Public Health, Nagoya 462 8576, Japan
    Jpn J Infect Dis 53:164-5. 2000
    ..Typhimurium have existed in healthy carriers as well as in diarrhea patients in 1980 to 1999...
  42. ncbi Long-term interferon therapy for 1 year or longer reduces the hepatocellular carcinogenesis rate in patients with liver cirrhosis caused by hepatitis C virus: a pilot study
    K Ikeda
    Department of Gastroenterology, Toranomon Hospital and Okinaka Memorial Institute for Medical Research, Tokyo, Japan
    J Gastroenterol Hepatol 16:406-15. 2001
    ..A total of 113 patients underwent interferon therapy, including 25 patients with a long-term administration of interferon for 1 year or more, and the other 581 patients received no antiviral drugs...
  43. ncbi T cell immune responses against melanoma and melanocytes in cancer and autoimmunity
    Y Kawakami
    Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Shinjukuku, Tokyo, Japan
    Pigment Cell Res 13:163-9. 2000
    ....
  44. ncbi Phylogenetic analysis of field isolates of feline calcivirus (FCV) in Japan by sequencing part of its capsid gene
    Y Sato
    Department of Microbiology, School of Veterinary Medicine, Azabu University, Fuchinobe, Kanagawa Ken, Japan
    Vet Res Commun 26:205-19. 2002
    ....
  45. ncbi Accelerated transport and maturation of lysosomal alpha-galactosidase A in Fabry lymphoblasts by an enzyme inhibitor
    J Q Fan
    Department of Membrane Biochemistry, Tokyo, Japan
    Nat Med 5:112-5. 1999
    ..We propose a new molecular therapeutic strategy for genetic metabolic diseases of administering competitive inhibitors as 'chemical chaperons' at sub-inhibitory intracellular concentrations...
  46. ncbi Novel cytochrome P4501B1 (CYP1B1) gene mutations in Japanese patients with primary congenital glaucoma
    Y Mashima
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 42:2211-6. 2001
    ..To investigate CYP1B1 gene mutations in Japanese patients with primary congenital glaucoma (PCG)...
  47. ncbi Mouse coq7/clk-1 orthologue rescued slowed rhythmic behavior and extended life span of clk-1 longevity mutant in Caenorhabditis elegans
    M Takahashi
    Department of Molecular Genetics, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakae cho, Itabashi ku, Tokyo, 173 0015, Japan
    Biochem Biophys Res Commun 286:534-40. 2001
    ..These data strongly suggested that coq7 plays a pivotal role in the regulation of biological rhythms and the determination of life span in mammalian species...
  48. ncbi GM1-gangliosidosis: abnormalities in biosynthesis and early processing of beta-galactosidase in fibroblasts
    E Nanba
    Division of Inherited Metabolic Disease, National Institute of Neuroscience, Tokyo, Japan
    Biochem Biophys Res Commun 152:794-800. 1988
    ..No further processing occurred to the 88 kDa form. It was concluded that the enzyme deficiency was caused by heterogeneous molecular mutations of beta-galactosidase with a defect in early processing in this disease...
  49. ncbi Hemorrhagic transformation after fibrinolysis with tissue plasminogen activator: evaluation of role of hypertension with rat thromboembolic stroke model
    E Tejima
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    Stroke 32:1336-40. 2001
    ....
  50. ncbi Blockade of TGF-beta signaling in T cells prevents the development of experimental glomerulonephritis
    Y Kanamaru
    Allergy Research Center, Division of Nephrology Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 166:2818-23. 2001
    ..Our findings suggest that the development of anti-GBM Ab-induced GN requires TGF-beta/Smad signaling in T cells...
  51. ncbi Association of amino acid sequence in the PKR-eIF2 phosphorylation homology domain and response to interferon therapy
    K Chayama
    Department of Gastroenterology, Toranomon Hospital, Okinaka, Memorial Institute for Medical Research, Tokyo, Japan
    Hepatology 32:1138-44. 2000
    ..Our results suggest that amino-acid sequences of the PePHD domain may be related to viral resistance to IFN but do not predict the outcome of IFN therapy as amino-acid substitutions in this domain are rare...
  52. ncbi Heterogeneous mutations in the glycogen-debranching enzyme gene are responsible for glycogen storage disease type IIIa in Japan
    M Okubo
    Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan
    Hum Genet 106:108-15. 2000
    ..These results demonstrate the importance of the integrity of the carboxy terminal domain in the AGL protein and the molecular heterogeneity of GSD IIIa in Japan...
  53. ncbi Novel mutations of the autoimmune regulator gene in two siblings with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy
    T Ishii
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
    J Clin Endocrinol Metab 85:2922-6. 2000
    ..The results imply that the C-terminus of AIRE protein including the third LXXLL motif plays a critical role in the development of APECED, and that the phenotypic spectrum can vary between siblings with the same mutations...
  54. ncbi Compound heterozygous patient with glycogen storage disease type III: identification of two novel AGL mutations, a donor splice site mutation of Chinese origin and a 1-bp deletion of Japanese origin
    M Okubo
    Department of Endocrinology and Metabolism, Toranomon Hospital and Okinaka Memorial Institute for Medical Research, Tokyo, Japan
    Am J Med Genet 93:211-4. 2000
    ..To our knowledge, this is the first report of a mutation identified in a GSD III patient from the Chinese population...
  55. ncbi Mother-to-infant transmission of TT virus in Japan
    K Iso
    Department of Obstetrics and Gynecology, Tokyo Medical University, 6 7 1, Nishishinjuku, Shinjuku ku, Tokyo, Japan
    Int J Gynaecol Obstet 75:11-9. 2001
    ..In the present study, we determined the percentage of TTV carriers among pregnant women with no history of blood transfusion, and evaluated the possibility of mother-child transmission...
  56. ncbi Relationship between mast cells in the tubulointerstitium and prognosis of patients with IgA nephropathy
    A Kurusu
    Division of Nephrology, Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Nephron 89:391-7. 2001
    ..It appears that the number of mast cells in the nonfibrotic areas may be one of the predictive factors for the prognosis of patients with IgA nephropathy...
  57. ncbi Enterobacterial repetitive intergenic consensus sequence-based PCR (ERIC-PCR); its ability to differentiate Streptococcus pyogenes strains and applicability to the study of outbreaks of streptococcal infection
    M Matsumoto
    Department of Microbiology, Aichi Prefectural Institute of Public Health, Nagoya, Japan
    Tohoku J Exp Med 194:205-12. 2001
    ..ERIC-PCR has sufficient discriminatory power and is a quick and relatively easy technique, making it useful for routine epidemiological investigations...
  58. ncbi Familial clustering in subgroups of gastric cancer stratified by histology, age group and location
    K Eto
    Department of Surgery, The Cancer Institute Hospital, Toshima ku, Tokyo, Japan
    Eur J Surg Oncol 32:743-8. 2006
    ..To assess the risk of gastric cancer in a Japanese patient population with the disease by stratification with histology, age, tumour location and the association with family history of gastric or non-gastric tumours...
  59. ncbi Epidemiological investigation of a fatal case of cholera in Japan by phenotypic techniques and pulsed-field gel electrophoresis
    M Matsumoto
    Department of Microbiology, Aichi Prefectural Institute of Public Health, Nagoya, Aichi, Japan
    J Med Microbiol 51:264-8. 2002
    ..These results suggest that a new clone was introduced after 1993 from overseas and then disseminated into Aichi, and this may have been an important step in triggering the fatal case of cholera...
  60. doi Occult hepatitis B virus infection increases hepatocellular carcinogenesis by eight times in patients with non-B, non-C liver cirrhosis: a cohort study
    K Ikeda
    Department of Hepatology, Toranomon Hospital, Minato ku, Tokyo, Japan
    J Viral Hepat 16:437-43. 2009
    ..005) were independently associated with hepatocellular carcinogenesis. Existence of serum HBV DNA predicted a high hepatocellular carcinogenesis rate in a cohort of patients with non-B, non-C cirrhosis...
  61. ncbi Intake of conjugated eicosapentaenoic acid suppresses lipid accumulation in liver and epididymal adipose tissue in rats
    Tsuyoshi Tsuzuki
    Department of Food Management, School of Food, Agricultural and Environment Sciences, Miyagi University, Sendai 982 0215, Japan
    Lipids 40:1117-23. 2005
    ..These results suggest that intake of CEPA suppresses lipid accumulation in the liver and epididymal adipose tissue while increasing lipid catabolism in rats...
  62. ncbi Fredericamycin A affects mitochondrial inheritance and morphology in Saccharomyces cerevisiae
    Yuko Imamura
    Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Japan
    Biosci Biotechnol Biochem 69:2213-8. 2005
    ..Our results suggest that mitochondria are the primary target site of FMA...
  63. ncbi Induction of apoptosis in human leukemia cells by naturally fermented sugar cane vinegar (kibizu) of Amami Ohshima Island
    Akio Mimura
    Department of Biotechnology, Faculty of Engineering, University of Yamanashi, Kofu, Japan
    Biofactors 22:93-7. 2004
    ..These results led us the consideration that active components in sugar cane juice could be converted to more lipophilic compounds with activity to induce apoptosis in HL-60 by microbial fermentation with yeast and acetic acid bacteria...
  64. ncbi Biotransformation of cystothiazole A, a myxobacterial antibiotic, into novel derivatives by the mother producer, Cystobacter fuscus
    Yoshihiro Suzuki
    Graduate School of Bioagricultural Sciences, Nagoya University, Japan
    Biosci Biotechnol Biochem 68:390-6. 2004
    ..Based on the time-dependent production profile and chemical structures of these derivatives, pathways for the conversion of cystothiazole A to the more polar derivatives of this antibiotic by C. fuscus are proposed...
  65. ncbi IL-12-induced production of IL-10 and interferon-gamma by mononuclear cells in lung cancer-associated malignant pleural effusions
    Eiji Takeuchi
    Third Department of Internal Medicine, The University of Tokushima School of Medicine, Kuramoto Cho 3, Tokushima 770 8503, Japan
    Lung Cancer 35:171-7. 2002
    ..These observations suggest that control of IL-10 production at the microenvironment level may be important for the efficacy of human lung cancer immunotherapy with IL-12...
  66. ncbi Effect of etidronate on COX-2 expression and PGE(2) production in macrophage-like RAW 264.7 cells stimulated by titanium particles
    Yoshihiro Suzuki
    Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    J Orthop Sci 12:568-77. 2007
    ..However, the mechanism of bisphosphonates that reduces periprosthetic bone resorption remains unclear. The purpose of this study was to investigate one of the mechanisms by which etidronate (EHDP) inhibits periprosthetic bone resorption...