N Sugano

Summary

Affiliation: Nihon University
Country: Japan

Publications

  1. ncbi request reprint Biological plaque control: novel therapeutic approach to periodontal disease
    Naoyuki Sugano
    Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan
    J Oral Sci 54:1-5. 2012
  2. ncbi request reprint Nicotine inhibits the production of inflammatory mediators in U937 cells through modulation of nuclear factor-kappaB activation
    N Sugano
    Department of Periodontology, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo, 101 8310, Japan
    Biochem Biophys Res Commun 252:25-8. 1998
  3. ncbi request reprint Relationship between Porphyromonas gingivalis, Epstein-Barr virus infection and reactivation in periodontitis
    Naoyuki Sugano
    Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan
    J Oral Sci 46:203-6. 2004
  4. ncbi request reprint Differential cytokine induction by two types of Porphyromonas gingivalis
    N Sugano
    Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan
    Oral Microbiol Immunol 19:121-3. 2004
  5. ncbi request reprint Detection of Streptococcus anginosus and 8-hydroxydeoxyguanosine in saliva
    Naoyuki Sugano
    Department of Periodontology, Nihon University School of Dentistry, Tokyo 101 8310, Japan
    J Oral Sci 45:181-4. 2003
  6. ncbi request reprint Nicotine inhibits UV-induced activation of the apoptotic pathway
    N Sugano
    Department of Periodontololgy, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, 101 8310, Tokyo, Japan
    Toxicol Lett 125:61-5. 2001
  7. ncbi request reprint Detection of mitochondrial DNA mutations in human gingival tissues
    N Sugano
    Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan
    J Oral Sci 42:221-3. 2000
  8. ncbi request reprint Nicotine switches the form of H(2)O(2)-induced cell death from apoptosis to necrosis in U937 cells
    N Sugano
    Department of Periodontology, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, 101 8310, Tokyo, Japan
    Immunol Lett 72:163-6. 2000
  9. ncbi request reprint Cyclosporin A inhibits collagenase gene expression via AP-1 and JNK suppression in human gingival fibroblasts
    N Sugano
    Nihon University School of Dentistry, Department of Periodontology, Tokyo, Japan
    J Periodontal Res 33:448-52. 1998
  10. ncbi request reprint Cyclosporin A inhibits H2O2-induced apoptosis of human fibroblasts
    N Sugano
    Nihon University School of Dentistry, Department of Periodontology, Tokyo, Japan
    FEBS Lett 447:274-6. 1999

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Biological plaque control: novel therapeutic approach to periodontal disease
    Naoyuki Sugano
    Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan
    J Oral Sci 54:1-5. 2012
    ..Further study to evaluate the possible effects of these biological plaque control methods against periodontal disease is warranted...
  2. ncbi request reprint Nicotine inhibits the production of inflammatory mediators in U937 cells through modulation of nuclear factor-kappaB activation
    N Sugano
    Department of Periodontology, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo, 101 8310, Japan
    Biochem Biophys Res Commun 252:25-8. 1998
    ..These inhibitory effects of nicotine may contribute to cigarette smoke-induced immunosuppression...
  3. ncbi request reprint Relationship between Porphyromonas gingivalis, Epstein-Barr virus infection and reactivation in periodontitis
    Naoyuki Sugano
    Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan
    J Oral Sci 46:203-6. 2004
    ..gingivalis is bi-directional, with EBV reactivation suppressing host defenses and permitting overgrowth of P. gingivalis, and P. gingivalis having the potential to induce EBV reactivation...
  4. ncbi request reprint Differential cytokine induction by two types of Porphyromonas gingivalis
    N Sugano
    Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan
    Oral Microbiol Immunol 19:121-3. 2004
    ..Although other factors may also be involved, the sustained cytokine response induced by type II P. gingivalis may play an important role in enhanced periodontal tissue inflammation and destruction...
  5. ncbi request reprint Detection of Streptococcus anginosus and 8-hydroxydeoxyguanosine in saliva
    Naoyuki Sugano
    Department of Periodontology, Nihon University School of Dentistry, Tokyo 101 8310, Japan
    J Oral Sci 45:181-4. 2003
    ..anginosus are relatively low, there is a correlation between the salivary level of S. anginosus and 8-OHdG, and that periodontal treatment can decrease the levels of these hazard factors...
  6. ncbi request reprint Nicotine inhibits UV-induced activation of the apoptotic pathway
    N Sugano
    Department of Periodontololgy, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, 101 8310, Tokyo, Japan
    Toxicol Lett 125:61-5. 2001
    ..Thus, our results suggest that the inhibition of apoptosis by nicotine contributes to the increased incidence of cancer in smokers...
  7. ncbi request reprint Detection of mitochondrial DNA mutations in human gingival tissues
    N Sugano
    Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan
    J Oral Sci 42:221-3. 2000
    ..0-kb and 7.4-kb deletions were found in the mitochondrial genomes of these subjects. This is the first report of mitochondrial DNA deletion detectable in human gingival tissues...
  8. ncbi request reprint Nicotine switches the form of H(2)O(2)-induced cell death from apoptosis to necrosis in U937 cells
    N Sugano
    Department of Periodontology, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, 101 8310, Tokyo, Japan
    Immunol Lett 72:163-6. 2000
    ..These results suggest that nicotine can alter the cell death pathway by reducing the level of intracellular ATP, and that this effect may contribute to cigarette smoke-induced tissue destruction...
  9. ncbi request reprint Cyclosporin A inhibits collagenase gene expression via AP-1 and JNK suppression in human gingival fibroblasts
    N Sugano
    Nihon University School of Dentistry, Department of Periodontology, Tokyo, Japan
    J Periodontal Res 33:448-52. 1998
    ..These activations were blocked by CsA. We suggest that inhibitory effects of CsA on LPS-induced signal transduction may contribute to the mechanism of CsA-induced gingival overgrowth...
  10. ncbi request reprint Cyclosporin A inhibits H2O2-induced apoptosis of human fibroblasts
    N Sugano
    Nihon University School of Dentistry, Department of Periodontology, Tokyo, Japan
    FEBS Lett 447:274-6. 1999
    ..Thus, our results suggest that the inhibition of apoptosis by CsA may at least partly contribute to the anti-inflammatory effect of CsA...
  11. doi request reprint Relationship between salivary antioxidant capacity and phases of the menstrual cycle
    A Kawamoto
    Dental Hygienist Section, Nihon University School of Dentistry Dental Hospital, Tokyo, Japan
    J Periodontal Res 47:593-8. 2012
    ..This study examined changes in salivary antioxidant activities, clinical parameters and bacterial levels during the menstrual cycle...
  12. doi request reprint Differential effects of five Aggregatibacter actinomycetemcomitans strains on gingival epithelial cells
    T Shimada
    Nihon University Graduate School of Dentistry, Tokyo, Japan
    Oral Microbiol Immunol 23:455-8. 2008
    ..We investigated gingival epithelial cell proliferation and expression of interleukin-8 (IL-8) and intercellular adhesion molecule 1 (ICAM-1) in response to Aggregatibacter actinomycetemcomitans serotypes a, b, and c...
  13. doi request reprint Salivary microbial levels in relation to periodontal status and caries development
    Y Iwano
    Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan
    J Periodontal Res 45:165-9. 2010
    ..The aim of the present study was to examine the relationship between caries and periodontal disease...
  14. ncbi request reprint Protease-activated receptor 2 mediates interleukin-8 and intercellular adhesion molecule-1 expression in response to Aggregatibacter actinomycetemcomitans
    T Shimada
    Nihon University Graduate School of Dentistry, Tokyo 101 8310, Japan
    Oral Microbiol Immunol 24:285-91. 2009
    ..We investigated the mechanisms by which extracts of Aggregatibacter actinomycetemcomitans affect the inflammatory response in gingival epithelial cells...
  15. ncbi request reprint Detection of periodontopathic bacteria and an oxidative stress marker in saliva from periodontitis patients
    Y Sawamoto
    Department of Periodontology, Division of Advanced Dental Treatment, Dental Research Center, Tokyo, Japan
    Oral Microbiol Immunol 20:216-20. 2005
    ..These results suggest that the 8-OHdG levels in saliva reflect the load of periodontal pathogens. 8-OHdG could be a useful biomarker for assessing periodontal status accurately, and for evaluating the efficacy of periodontal treatment...
  16. ncbi request reprint Detection of Epstein-Barr virus in saliva by real-time PCR
    M Idesawa
    Department of Periodontology, Dental Reseach Center, Nihon University Graduate School of Dentistry, Tokyo, Japan
    Oral Microbiol Immunol 19:230-2. 2004
    ..A significant decrease in EBV levels was observed after initial periodontal treatment. Our findings indicate that levels of EBV in saliva may reflect the status of periodontal inflammation...
  17. doi request reprint Relationship between oral malodor and the menstrual cycle
    A Kawamoto
    Dental Hygienist Section, Nihon University Dental Hospital, Tokyo, Japan
    J Periodontal Res 45:681-7. 2010
    ..This study examined changes in volatile sulfur compounds (VSC) levels, clinical parameters and bacterial levels during the menstrual cycle...
  18. ncbi request reprint The effect of Porphyromonas gingivalis infection on cytokine levels in type 2 diabetic mice
    R Nishihara
    Nihon University Graduate School of Dentistry, Tokyo, Japan
    J Periodontal Res 44:305-10. 2009
    ..The aim of this study was to compare the inflammatory response to Porphyromonas gingivalis infection in normal and diabetic mice...
  19. doi request reprint The effect of butyric acid on adhesion molecule expression by human gingival epithelial cells
    S Takigawa
    Nihon University Graduate School of Dentistry, Chiyoda ku, Tokyo, Japan
    J Periodontal Res 43:386-90. 2008
    ..In the present study, we examined the effects of butyric acid on adhesion molecule expression by human gingival epithelial cells...
  20. ncbi request reprint Activity of anti-Porphyromonas gingivalis egg yolk antibody against gingipains in vitro
    K Yokoyama
    Nihon University Graduate School of Dentistry, Tokyo, Japan
    Oral Microbiol Immunol 22:352-5. 2007
    ..We investigated the effect of anti-Porphyromonas gingivalis egg yolk antibody against gingipains [immunoglobulin Y (IgY)-GP] on gingipain activity in vitro...
  21. doi request reprint Hepatocytes produce tumor necrosis factor-α and interleukin-6 in response to Porphyromonas gingivalis
    M Takano
    Nihon University Graduate School of Dentistry, Tokyo, Japan Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan
    J Periodontal Res 47:89-94. 2012
    ..The aim of this study was to investigate the production of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) by hepatocytes in response to periodontal pathogens...
  22. ncbi request reprint Microarray analysis of nicotine-induced changes in gene expression in a macrophage-like human cell line
    R Koshi
    Nihon University Graduate School of Dentistry, Tokyo, Japan
    J Periodontal Res 42:518-26. 2007
    ..However, the mechanisms underlying these effects are unclear. Using DNA microarrays, we monitored differentially expressed genes, responsive to nicotine, in a macrophage-like human cell line...
  23. ncbi request reprint Detection of Streptococcus anginosus from saliva by real-time polymerase chain reaction
    K Kumagai
    Department of Periodontology, Nihon University School of Dentistry, Kanda Surugadai, Chiyoda ku, Tokyo, Japan
    Lett Appl Microbiol 37:370-3. 2003
    ..The purpose of the present investigation was to assess the salivary levels of Streptococcus anginosus in periodontitis patients...
  24. ncbi request reprint Effects of egg yolk antibody against Porphyromonas gingivalis gingipains in periodontitis patients
    Kyosuke Yokoyama
    Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan
    J Oral Sci 49:201-6. 2007
    ..gingivalis was sustained in the IgY-GP group. Within the limitations of the present study, IgY-GP was shown to be an effective immunotherapeutic agent in the treatment of periodontitis...
  25. ncbi request reprint New biomarker evidence of oxidative DNA damage in whole saliva from clinically healthy and periodontally diseased individuals
    Masatoshi Takane
    Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan
    J Periodontol 73:551-4. 2002
    ..The aim of the present study was to evaluate 8-OHdG levels in whole saliva of patients with periodontitis and to assess the changes after initial treatment...
  26. ncbi request reprint A marker of oxidative stress in saliva: association with periodontally-involved teeth of a hopeless prognosis
    Masatoshi Takane
    Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan
    J Oral Sci 47:53-7. 2005
    ..These data suggest that periodontally-involved teeth of hopeless prognosis are a major source of salivary 8-OHdG. Measurement of salivary 8-OHdG levels may prove to be useful in identifying patients with teeth of hopeless prognosis...
  27. ncbi request reprint Surgical technique for management of Takayasu's arteritis
    T Iwai
    First Department of Surgery, School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Int J Cardiol 75:S135-40. 2000
    ..Careful differential diagnosis is essential to the success of this method, which may also be used to treat aortic aneurysm resulting from Behcet's disease but which is not appropriate for mid-aortic syndrome or Buerger's disease...
  28. ncbi request reprint Oral bacteria are a possible risk factor for valvular incompetence in primary varicose veins
    N Kurihara
    Department of Vascular and Applied Surgery and Periodontology, Tokyo Medical and Dental University Graduate School of Medicine and Dentisty, Tokyo, Japan
    Eur J Vasc Endovasc Surg 34:102-6. 2007
    ....
  29. ncbi request reprint Profiling the cytokines in gingival crevicular fluid using a cytokine antibody array
    Akihiko Sakai
    Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan
    J Periodontol 77:856-64. 2006
    ..This study sought novel marker proteins specific to chronic periodontitis by profiling cytokines in GCF using a cytokine antibody array system...
  30. doi request reprint The effect of systemic anti-tumor necrosis factor-alpha treatment on Porphyromonas gingivalis infection in type 2 diabetic mice
    Mayuko Takano
    Nihon University Graduate School of Dentistry, Tokyo, Japan
    Arch Oral Biol 55:379-84. 2010
    ..This study examined the effect of anti-TNF-alpha antibody treatment on Porphyromonas gingivalis infection in diabetic mice...
  31. ncbi request reprint Differential gene induction in macrophage-like human cells by two types of Porphyromonas gingivalis: a microarray study
    Maiko Oshikawa
    Nihon University Graduate School of Dentistry, Tokyo, Japan
    J Oral Sci 46:9-14. 2004
    ..Our results indicate that compared with Pg-I, Pg-II induces a low host response as measured by its weak induction of gene expression...