Research Topics
Genomes and Genes
| Taro MatsumotoSummaryAffiliation: Nihon University Country: Japan Publications
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Detail Information
Publications
Signal transduction via vascular endothelial growth factor (VEGF) receptors and their roles in atherogenesisTaro Matsumoto
Division of Cell Regeneration and Transplantation, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan
J Atheroscler Thromb 13:130-5. 2006..These phosphorylation sites may be useful targets for the development of anti-angiogenic therapies to treat atherosclerosis and cancer...
Differences in adipocytokines and fatty acid composition between two adipocyte fractions of small and large cells in high-fat diet-induced obese miceYoshiyuki Matsubara
Division of Cell Regeneration and Transplantation, Advanced Medical Research Center, Nihon University School of Medicine, 30 1 Ohyaguchi Kamimachi Itabashi ku, Tokyo 173 8610, Japan
Ann Nutr Metab 54:258-67. 2009..This study was conducted to compare the differences in adipocytokines and fatty acid composition between two fraction sizes of small and large cells from subcutaneous and visceral fat of mice receiving a high-fat diet (HFD)...- Losartan improves the impaired function of endothelial progenitor cells in hypertension via an antioxidant effectEn Hui Yao
Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
Hypertens Res 30:1119-28. 2007..This is the first report to show that losartan improves the proliferation and function of EPCs in hypertension, suggesting that ARBs are useful to repair hypertensive vascular injuries... - Effects of the antioxidative beta-blocker celiprolol on endothelial progenitor cells in hypertensive ratsEn Hui Yao
Division of Nephrology Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
Am J Hypertens 21:1062-8. 2008..EPC function is impaired by oxidative stress. We examined the effects of an antioxidative beta1-adrenoceptor blocker on the number and function of EPCs in hypertensive rats... - Transplantation of mature adipocyte-derived dedifferentiated fat (DFAT) cells improves urethral sphincter contractility in a rat modelDaisuke Obinata
Department of Urology, Division of Cell Regeneration and Transplantation, Nihon University School of Medicine, Tokyo, Japan
Int J Urol 18:827-34. 2011..To examine the effects of mature adipocyte-derived dedifferentiated fat (DFAT) cell transplantation on urethral tissue regeneration and sphincter function... - Treatment with valsartan stimulates endothelial progenitor cells and renal label-retaining cells in hypertensive ratsYoshinori Yoshida
Division of Nephrology Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
J Hypertens 29:91-101. 2011..We examined effects of treatment with valsartan on endothelial progenitor cells (EPCs) and renal LRCs in stroke-prone spontaneously hypertensive rats (SHR-SP)... - Mature, adipocyte derived, dedifferentiated fat cells can differentiate into smooth muscle-like cells and contribute to bladder tissue regenerationTakahiro Sakuma
Department of Urology, Nihon University School of Medicine, Nihon University, Tokyo, Japan
J Urol 182:355-65. 2009..In the current study we investigated whether such cells could differentiate into a smooth muscle cell lineage and contribute to bladder tissue regeneration in a mouse bladder injury model... - Dedifferentiated fat cells convert to cardiomyocyte phenotype and repair infarcted cardiac tissue in ratsMedet Jumabay
Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo 173 8610, Japan
J Mol Cell Cardiol 47:565-75. 2009..We propose that DFAT cells represent a promising candidate cell source for cardiomyocyte regeneration in severe ischemic heart disease... - Effects of atorvastatin on angiogenesis in hindlimb ischemia and endothelial progenitor cell formation in ratsMitsuyasu Matsumura
Department of Cardiovascular Surgery, Nihon University School of Medicine, Tokyo, Japan
J Atheroscler Thromb 16:319-26. 2009..The function and number of endothelial progenitor cells (EPCs) were investigated in hypertensive rats... - A novel gene silencer, pyrrole-imidazole polyamide targeting human lectin-like oxidized low-density lipoprotein receptor-1 gene improves endothelial cell functionTakahiro Ueno
Department of Medicine, Division of Nephrology, Hypertension and Endocrinology, Itabashi, Nihon University School of Medicine, Itabashi, Tokyo, Japan
J Hypertens 27:508-16. 2009..Molecular recognition of DNA by small molecules could provide insight into the development of new human medicines... - Low invasive angiogenic therapy for myocardial infarction by retrograde transplantation of mononuclear cells expressing the VEGF geneKazuhiro Hagikura
Department of Advanced Medicine, Nihon University School of Medicine, Division of Cell Regeneration and Transplantation, 30 1, Oyaguchi, Kami machi, Itabashi ku, 173 8610, Tokyo, Japan
Int J Cardiol 142:56-64. 2010..We examined the effects of transplantation of peripheral MNCs expressing an exogenous vascular endothelial growth factor (VEGF) gene in a pig model of acute myocardial infarction (AMI)... - Appropriate doses of granulocyte-colony stimulating factor reduced atherosclerotic plaque formation and increased plaque stability in cholesterol-fed rabbitsTaro Matsumoto
Divsion of Cell Regeneration and Transplantation, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo 173 8610, Japan
J Atheroscler Thromb 17:84-96. 2010.... - Protective effects of statin on cardiac fibrosis and apoptosis in adrenomedullin-knockout mice treated with angiotensin II and high salt loadingChii Yamamoto
Division of Life Science, Advanced Research Institute for the Sciences and Humanities, Nihon University Graduate School, Tokyo, Japan
Hypertens Res 34:348-53. 2011..Thus, statins have potent cardioprotective effects that may be associated with anti-fibrotic, proangiogenic and anti-apoptotic effects in Ang II/salt-loading AM(+/-) mice... - Influence of genetic polymorphisms in oxidative stress related genes and smoking on plasma MDA-LDL, soluble CD40 ligand, E-selectin and soluble ICAM1 levels in patients with coronary artery diseaseTakahiro Ueno
Department of Medicine, Division of Nephrology, Hypertension and Endocrinology, Nihon University School of Medicine, Tokyo, Japan
Med Sci Monit 15:CR341-8. 2009..Previous studies have shown that oxidative stress plays an important role in coronary heart disease. Polymorphisms in key enzymes that regulate oxidative stress may play a role in atherogenicity and were investigated in this study... - Atherogenic dyslipidemia and altered hepatic gene expression in SHRSP.Z-Leprfa/IzmDmcr ratsTakahiro Ueno
Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Itabashi ku, Tokyo 173 8610, Japan
Int J Mol Med 23:313-20. 2009..Three of ten genes upregulated in liver tissues of SHRSP fatty rats play a role in this metabolic abnormality and are a therapeutic target of this metabolic syndrome... - Effects of G-CSF on cardiac remodeling and arterial hyperplasia in ratsYuxin Li
Department of Internal Medicine, Nihon University School of Medicine, Tokyo 173-8610, Japan
Eur J Pharmacol 549:98-106. 2006..The effect of G-CSF on cardiac and vascular remodeling may occur mainly through a direct action on the heart and arteries... 
Role of complement 3a in the synthetic phenotype and angiotensin II-production in vascular smooth muscle cells from spontaneously hypertensive ratsYing Han
Division of Nephrology, Hypertension, and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
Am J Hypertens 25:284-9. 2012..To evaluate the contribution of complement 3 (C3) or C3a toward these abnormalities in SHR, we examined effects of a C3a receptor inhibitor on proliferation, phenotype, and Ang II-production in VSMCs from SHR and Wistar-Kyoto (WKY) rats...- Mature adipocyte-derived dedifferentiated fat cells exhibit multilineage potentialTaro Matsumoto
Division of Cell Regeneration and Transplantation, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan
J Cell Physiol 215:210-22. 2008..These results indicate that DFAT cells represent a type of multipotent progenitor cell. The accessibility and ease of culture of DFAT cells support their potential application for cell-based therapies... - Effects of an ARB on endothelial progenitor cell function and cardiovascular oxidation in hypertensionYi Yu
Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
Am J Hypertens 21:72-7. 2008..We investigated the effects of an ARB, candesartan, on EPC function and cardiovascular oxidation in salt-loaded, stroke-prone, spontaneously hypertensive rats (SHR-SP) in vivo... - Zinc-finger transcriptional factor Sall1 induces angiogenesis by activation of the gene for VEGF-AChii Yamamoto
Advanced Research Institute of Science and Humanities, Nihon University, Tokyo, Japan
Hypertens Res 33:143-8. 2010..These results suggest that Sall1 induces angiogenesis by stimulating VEGF-A promoter activity... - Association of SLC6A9 gene variants with human essential hypertensionTakahiro Ueno
Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Itabashi 173 8610, Tokyo, Japan
J Atheroscler Thromb 16:201-6. 2009..In the present study, we therefore explored the role of SLC6A9 genetic variations in human essential hypertension (EH)... - Mouse embryonic stem cells give rise to gut-like morphogenesis, including intestinal stem cells, in the embryoid body modelNoriyoshi Konuma
Division of Cell Regeneration and Transplantation, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan
Stem Cells Dev 18:113-26. 2009..These results suggest the feasibility of cell-based therapy for intestinal failure based on ES cell culture systems... - Obesity alters the expression profile of clock genes in peripheral blood mononuclear cellsKazunobu Tahira
Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
Arch Med Sci 7:933-40. 2011..The aim of this study was to investigate the association between the variation in expression profile of clock genes and obesity using peripheral blood mononuclear (PMN) cells... - Implantation of dedifferentiated fat cells ameliorates habu snake venom-induced chronic renal dysfunction in tenascin-C-deficient miceRenaguli Nur
Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Nihon University, Tokyo, Japan
Nephron Exp Nephrol 110:e91-8. 2008..In this study, we evaluated the effect of implantation of DFAT cells on habu snake venom (HSV)-induced renal dysfunction in tenascin-C knockout (TC-KO) mice... - Moderate low temperature preserves the stemness of neural stem cells and suppresses apoptosis of the cells via activation of the cold-inducible RNA binding proteinKosuke Saito
Division of Life Science, Advanced Research Institute of the Sciences and Humanities, Nihon University Graduate School, Tokyo, Japan
Brain Res 1358:20-9. 2010.... - [Basic research for cardiovascular regeneration]Taro Matsumoto
Division of Cell Regeneration and Transplantation, Advanced Medical Research Center, Nihon University School of Medicine
Nippon Rinsho 64:547-51. 2006 - Paraoxonase1 polymorphism Leu-Met55 is associated with cerebral infarction in Japanese populationTakahiro Ueno
2nd Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
Med Sci Monit 9:CR208-12. 2003..We examined whether these polymorphisms relates with the incidence of cerebral infarction (CI) which is one of the major atherosclerotic disease in Japan... - Ubiquitin-positive foam cells are identified in the aortic and mitral valves with atherosclerotic involvementTsutomu Yamada
Department of Pathology, Nihon University School of Medicine, Tokyo, Japan
J Atheroscler Thromb 16:472-9. 2009.... - Postprandial plasma lipid levels are influenced by the interaction of functional polymorphisms in the microsome triglyceride transfer protein and beta3 adrenergic receptor genesTakahiro Ueno
Department of Medicine, Division of Nephrology and Endocrinology, Nihon University School of Medicine, Tokyo, Japan
Med Sci Monit 13:BR112-8. 2007..The effects of polymorphisms in the genes encoding microsome triglycerides transfer protein (MTP) and beta3-adrenergic receptor (beta3-AR) on lipid and glucose metabolism were investigated... - Hyperglycemia and lipopolysaccharide decrease depression effect of interleukin 8 production by hypothermia: an experimental study with endothelial cellsAkihiro Noda
Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Itabashi ku, Tokyo 173 8610, Japan
Intensive Care Med 34:109-15. 2008..This study assessed whether hyperglycemia and lipopolysaccharide (LPS) decrease the depression effect of interleukin (IL) 8 production by hypothermia in endothelial cells... - Development of angiogenic cell and gene therapy by transplantation of umbilical cord blood with vascular endothelial growth factor geneYukihiro Ikeda
Second Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
Hypertens Res 27:119-28. 2004.... - VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesisTaro Matsumoto
Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
EMBO J 24:2342-53. 2005..Tumor vascularization and growth was reduced in TSAd-deficient mice, indicating a critical role of Y951-TSAd signaling in pathological angiogenesis... - The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migrationKristina Holmqvist
Department of Medical Cell Biology, Uppsala University, Uppsala 75123, Sweden
J Biol Chem 279:22267-75. 2004..This is achieved by Shb binding to tyrosine 1175 in the VEGFR-2, which regulates VEGF-induced formation of focal adhesions and cell migration, of which the latter occurs in a phosphatidylinositol 3-kinase-dependent manner... - Endostatin regulates endothelial cell adhesion and cytoskeletal organizationJohan Dixelius
Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, 751 85 Uppsala, Sweden
Cancer Res 62:1944-7. 2002..These data provide a molecular basis both for the lack of effect of endostatin on the normal, quiescent vasculature, and its antagonistic effects on stimulated tumor vessels... - VEGF-receptor signal transductionMichael J Cross
Department of Genetics and Pathology, , 751 85 Uppsala, Sweden
Trends Biochem Sci 28:488-94. 2003..More recent data indicate essential roles for the VEGFs in haematopoietic cell function and in lymphangiogenesis... - Body distribution of trace elements in black-tailed gulls from Rishiri Island, Japan: age-dependent accumulation and transfer to feathers and eggsTetsuro Agusa
Center for Marine Environmental Studies, Ehime University, Bunkyo-cho 2-5, Matsuyama 790-8577, Japan
Environ Toxicol Chem 24:2107-20. 2005..To our knowledge, this is the first report on the maternal transfer rate of multielements and also on the usefulness of feathers to estimate contamination status of Hg in birds on a population basis... - [Dyslipidemia in renal failure]Takayuki Fujioka
Second Department of Internal Medicine, Nihon University School of Medicine
Nippon Rinsho 62:118-23. 2004 - Proteomic analysis of vascular endothelial growth factor-induced endothelial cell differentiation reveals a role for chloride intracellular channel 4 (CLIC4) in tubular morphogenesisSvante Bohman
Department of Genetics and Pathology, Uppsala University, Dag Hammarskjölds väg 20, S 751 85 Uppsala, Sweden
J Biol Chem 280:42397-404. 2005..Antisense- and small interfering RNA-mediated suppression of CLIC4 expression led to arrest in tubular morphogenesis. Our data implicate CLIC4 in formation of a vessel lumen... - Digoxin inhibits neuroblastoma tumor growth in miceAsa Svensson
Department of Medical Cell Biology, Children's Hospital, Uppsala University, Sweden
Anticancer Res 25:207-12. 2005..CONCLUSION: Our data suggest that digoxin may be a specific neuroblastoma growth inhibitor and an unspecific inhibitor of angiogenesis... - p38 MAP kinase negatively regulates endothelial cell survival, proliferation, and differentiation in FGF-2-stimulated angiogenesisTaro Matsumoto
Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, S-751 85, Sweden
J Cell Biol 156:149-60. 2002..These results implicate p38 in organization of new vessels and suggest that p38 is an essential regulator of FGF-2-driven angiogenesis...