Taro Matsumoto

Summary

Affiliation: Nihon University
Country: Japan

Publications

  1. ncbi request reprint Differences in adipocytokines and fatty acid composition between two adipocyte fractions of small and large cells in high-fat diet-induced obese mice
    Yoshiyuki Matsubara
    Division of Cell Regeneration and Transplantation, Advanced Medical Research Center, Nihon University School of Medicine, 30 1 Ohyaguchi Kamimachi Itabashi ku, Tokyo 173 8610, Japan
    Ann Nutr Metab 54:258-67. 2009
  2. ncbi request reprint Signal transduction via vascular endothelial growth factor (VEGF) receptors and their roles in atherogenesis
    Taro Matsumoto
    Division of Cell Regeneration and Transplantation, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 13:130-5. 2006
  3. doi request reprint Losartan improves the impaired function of endothelial progenitor cells in hypertension via an antioxidant effect
    En Hui Yao
    Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Hypertens Res 30:1119-28. 2007
  4. ncbi request reprint Effects of the antioxidative beta-blocker celiprolol on endothelial progenitor cells in hypertensive rats
    En Hui Yao
    Division of Nephrology Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Am J Hypertens 21:1062-8. 2008
  5. ncbi request reprint Dedifferentiated fat cells convert to cardiomyocyte phenotype and repair infarcted cardiac tissue in rats
    Medet Jumabay
    Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo 173 8610, Japan
    J Mol Cell Cardiol 47:565-75. 2009
  6. doi request reprint Transplantation of mature adipocyte-derived dedifferentiated fat (DFAT) cells improves urethral sphincter contractility in a rat model
    Daisuke Obinata
    Department of Urology, Division of Cell Regeneration and Transplantation, Nihon University School of Medicine, Tokyo, Japan
    Int J Urol 18:827-34. 2011
  7. ncbi request reprint Low invasive angiogenic therapy for myocardial infarction by retrograde transplantation of mononuclear cells expressing the VEGF gene
    Kazuhiro Hagikura
    Department of Advanced Medicine, Nihon University School of Medicine, Division of Cell Regeneration and Transplantation, 30 1, Oyaguchi, Kami machi, Itabashi ku, 173 8610, Tokyo, Japan
    Int J Cardiol 142:56-64. 2010
  8. ncbi request reprint Effects of atorvastatin on angiogenesis in hindlimb ischemia and endothelial progenitor cell formation in rats
    Mitsuyasu Matsumura
    Department of Cardiovascular Surgery, Nihon University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 16:319-26. 2009
  9. doi request reprint Mature, adipocyte derived, dedifferentiated fat cells can differentiate into smooth muscle-like cells and contribute to bladder tissue regeneration
    Takahiro Sakuma
    Department of Urology, Nihon University School of Medicine, Nihon University, Tokyo, Japan
    J Urol 182:355-65. 2009
  10. doi request reprint Treatment with valsartan stimulates endothelial progenitor cells and renal label-retaining cells in hypertensive rats
    Yoshinori Yoshida
    Division of Nephrology Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    J Hypertens 29:91-101. 2011

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Differences in adipocytokines and fatty acid composition between two adipocyte fractions of small and large cells in high-fat diet-induced obese mice
    Yoshiyuki Matsubara
    Division of Cell Regeneration and Transplantation, Advanced Medical Research Center, Nihon University School of Medicine, 30 1 Ohyaguchi Kamimachi Itabashi ku, Tokyo 173 8610, Japan
    Ann Nutr Metab 54:258-67. 2009
    ..This study was conducted to compare the differences in adipocytokines and fatty acid composition between two fraction sizes of small and large cells from subcutaneous and visceral fat of mice receiving a high-fat diet (HFD)...
  2. ncbi request reprint Signal transduction via vascular endothelial growth factor (VEGF) receptors and their roles in atherogenesis
    Taro Matsumoto
    Division of Cell Regeneration and Transplantation, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 13:130-5. 2006
    ..These phosphorylation sites may be useful targets for the development of anti-angiogenic therapies to treat atherosclerosis and cancer...
  3. doi request reprint Losartan improves the impaired function of endothelial progenitor cells in hypertension via an antioxidant effect
    En Hui Yao
    Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Hypertens Res 30:1119-28. 2007
    ..This is the first report to show that losartan improves the proliferation and function of EPCs in hypertension, suggesting that ARBs are useful to repair hypertensive vascular injuries...
  4. ncbi request reprint Effects of the antioxidative beta-blocker celiprolol on endothelial progenitor cells in hypertensive rats
    En Hui Yao
    Division of Nephrology Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Am J Hypertens 21:1062-8. 2008
    ..EPC function is impaired by oxidative stress. We examined the effects of an antioxidative beta1-adrenoceptor blocker on the number and function of EPCs in hypertensive rats...
  5. ncbi request reprint Dedifferentiated fat cells convert to cardiomyocyte phenotype and repair infarcted cardiac tissue in rats
    Medet Jumabay
    Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo 173 8610, Japan
    J Mol Cell Cardiol 47:565-75. 2009
    ..We propose that DFAT cells represent a promising candidate cell source for cardiomyocyte regeneration in severe ischemic heart disease...
  6. doi request reprint Transplantation of mature adipocyte-derived dedifferentiated fat (DFAT) cells improves urethral sphincter contractility in a rat model
    Daisuke Obinata
    Department of Urology, Division of Cell Regeneration and Transplantation, Nihon University School of Medicine, Tokyo, Japan
    Int J Urol 18:827-34. 2011
    ..To examine the effects of mature adipocyte-derived dedifferentiated fat (DFAT) cell transplantation on urethral tissue regeneration and sphincter function...
  7. ncbi request reprint Low invasive angiogenic therapy for myocardial infarction by retrograde transplantation of mononuclear cells expressing the VEGF gene
    Kazuhiro Hagikura
    Department of Advanced Medicine, Nihon University School of Medicine, Division of Cell Regeneration and Transplantation, 30 1, Oyaguchi, Kami machi, Itabashi ku, 173 8610, Tokyo, Japan
    Int J Cardiol 142:56-64. 2010
    ..We examined the effects of transplantation of peripheral MNCs expressing an exogenous vascular endothelial growth factor (VEGF) gene in a pig model of acute myocardial infarction (AMI)...
  8. ncbi request reprint Effects of atorvastatin on angiogenesis in hindlimb ischemia and endothelial progenitor cell formation in rats
    Mitsuyasu Matsumura
    Department of Cardiovascular Surgery, Nihon University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 16:319-26. 2009
    ..The function and number of endothelial progenitor cells (EPCs) were investigated in hypertensive rats...
  9. doi request reprint Mature, adipocyte derived, dedifferentiated fat cells can differentiate into smooth muscle-like cells and contribute to bladder tissue regeneration
    Takahiro Sakuma
    Department of Urology, Nihon University School of Medicine, Nihon University, Tokyo, Japan
    J Urol 182:355-65. 2009
    ..In the current study we investigated whether such cells could differentiate into a smooth muscle cell lineage and contribute to bladder tissue regeneration in a mouse bladder injury model...
  10. doi request reprint Treatment with valsartan stimulates endothelial progenitor cells and renal label-retaining cells in hypertensive rats
    Yoshinori Yoshida
    Division of Nephrology Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    J Hypertens 29:91-101. 2011
    ..We examined effects of treatment with valsartan on endothelial progenitor cells (EPCs) and renal LRCs in stroke-prone spontaneously hypertensive rats (SHR-SP)...
  11. doi request reprint Complement 3 activates the renal renin-angiotensin system by induction of epithelial-to-mesenchymal transition of the nephrotubulus in mice
    Xueli Zhou
    Div of Nephrology, Hypertension, and Endocrinology, Dept of Medicine, Nihon Univ School of Medicine, Tokyo 173 8610, Japan
    Am J Physiol Renal Physiol 305:F957-67. 2013
    ..These data indicate for the first time that C3 may be a primary factor to activate the renal RA systems to induce hypertension...
  12. ncbi request reprint Appropriate doses of granulocyte-colony stimulating factor reduced atherosclerotic plaque formation and increased plaque stability in cholesterol-fed rabbits
    Taro Matsumoto
    Divsion of Cell Regeneration and Transplantation, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo 173 8610, Japan
    J Atheroscler Thromb 17:84-96. 2010
    ....
  13. doi request reprint Protective effects of statin on cardiac fibrosis and apoptosis in adrenomedullin-knockout mice treated with angiotensin II and high salt loading
    Chii Yamamoto
    Division of Life Science, Advanced Research Institute for the Sciences and Humanities, Nihon University Graduate School, Tokyo, Japan
    Hypertens Res 34:348-53. 2011
    ..Thus, statins have potent cardioprotective effects that may be associated with anti-fibrotic, proangiogenic and anti-apoptotic effects in Ang II/salt-loading AM(+/-) mice...
  14. ncbi request reprint A novel gene silencer, pyrrole-imidazole polyamide targeting human lectin-like oxidized low-density lipoprotein receptor-1 gene improves endothelial cell function
    Takahiro Ueno
    Department of Medicine, Division of Nephrology, Hypertension and Endocrinology, Itabashi, Nihon University School of Medicine, Itabashi, Tokyo, Japan
    J Hypertens 27:508-16. 2009
    ..Molecular recognition of DNA by small molecules could provide insight into the development of new human medicines...
  15. ncbi request reprint Influence of genetic polymorphisms in oxidative stress related genes and smoking on plasma MDA-LDL, soluble CD40 ligand, E-selectin and soluble ICAM1 levels in patients with coronary artery disease
    Takahiro Ueno
    Department of Medicine, Division of Nephrology, Hypertension and Endocrinology, Nihon University School of Medicine, Tokyo, Japan
    Med Sci Monit 15:CR341-8. 2009
    ..Previous studies have shown that oxidative stress plays an important role in coronary heart disease. Polymorphisms in key enzymes that regulate oxidative stress may play a role in atherogenicity and were investigated in this study...
  16. ncbi request reprint Atherogenic dyslipidemia and altered hepatic gene expression in SHRSP.Z-Leprfa/IzmDmcr rats
    Takahiro Ueno
    Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Itabashi ku, Tokyo 173 8610, Japan
    Int J Mol Med 23:313-20. 2009
    ..Three of ten genes upregulated in liver tissues of SHRSP fatty rats play a role in this metabolic abnormality and are a therapeutic target of this metabolic syndrome...
  17. pmc Role of complement 3a in the synthetic phenotype and angiotensin II-production in vascular smooth muscle cells from spontaneously hypertensive rats
    Ying Han
    Division of Nephrology, Hypertension, and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Am J Hypertens 25:284-9. 2012
    ..To evaluate the contribution of complement 3 (C3) or C3a toward these abnormalities in SHR, we examined effects of a C3a receptor inhibitor on proliferation, phenotype, and Ang II-production in VSMCs from SHR and Wistar-Kyoto (WKY) rats...
  18. ncbi request reprint Effects of G-CSF on cardiac remodeling and arterial hyperplasia in rats
    Yuxin Li
    Department of Internal Medicine, Nihon University School of Medicine, Tokyo 173 8610, Japan
    Eur J Pharmacol 549:98-106. 2006
    ..The effect of G-CSF on cardiac and vascular remodeling may occur mainly through a direct action on the heart and arteries...
  19. ncbi request reprint Mature adipocyte-derived dedifferentiated fat cells exhibit multilineage potential
    Taro Matsumoto
    Division of Cell Regeneration and Transplantation, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan
    J Cell Physiol 215:210-22. 2008
    ..These results indicate that DFAT cells represent a type of multipotent progenitor cell. The accessibility and ease of culture of DFAT cells support their potential application for cell-based therapies...
  20. pmc Osteogenic effects of dedifferentiated fat cell transplantation in rabbit models of bone defect and ovariectomy-induced osteoporosis
    Shinsuke Kikuta
    Department of Orthopedic Surgery, Nihon University School of Medicine, Tokyo, Japan
    Tissue Eng Part A 19:1792-802. 2013
    ..DFAT cells may be an attractive cell source for cell-based bone tissue engineering to treat nonunion fractures in all patients, including those with osteoporosis. ..
  21. ncbi request reprint Effects of an angiotensin II receptor blocker on the impaired function of endothelial progenitor cells in patients with essential hypertension
    Ryo Suzuki
    Division of Nephrology Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Am J Hypertens 27:695-701. 2014
    ..In this study, we investigated basal EPC functions in normotensive control subjects and patients with essential hypertension and the effect of losartan on EPC function in hypertensive patients...
  22. doi request reprint Zinc-finger transcriptional factor Sall1 induces angiogenesis by activation of the gene for VEGF-A
    Chii Yamamoto
    Advanced Research Institute of Science and Humanities, Nihon University, Tokyo, Japan
    Hypertens Res 33:143-8. 2010
    ..These results suggest that Sall1 induces angiogenesis by stimulating VEGF-A promoter activity...
  23. doi request reprint Mouse embryonic stem cells give rise to gut-like morphogenesis, including intestinal stem cells, in the embryoid body model
    Noriyoshi Konuma
    Division of Cell Regeneration and Transplantation, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan
    Stem Cells Dev 18:113-26. 2009
    ..These results suggest the feasibility of cell-based therapy for intestinal failure based on ES cell culture systems...
  24. ncbi request reprint Effects of an ARB on endothelial progenitor cell function and cardiovascular oxidation in hypertension
    Yi Yu
    Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Am J Hypertens 21:72-7. 2008
    ..We investigated the effects of an ARB, candesartan, on EPC function and cardiovascular oxidation in salt-loaded, stroke-prone, spontaneously hypertensive rats (SHR-SP) in vivo...
  25. ncbi request reprint Association of SLC6A9 gene variants with human essential hypertension
    Takahiro Ueno
    Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Itabashi 173 8610, Tokyo, Japan
    J Atheroscler Thromb 16:201-6. 2009
    ..In the present study, we therefore explored the role of SLC6A9 genetic variations in human essential hypertension (EH)...
  26. ncbi request reprint A novel gene regulator, pyrrole-imidazole polyamide targeting ABCA1 gene increases cholesterol efflux from macrophages and plasma HDL concentration
    Akiko Tsunemi
    Department of Medicine, Division of Nephrology, Hypertension and Endocrinology, Nihon University School of Medicine, 30 1 Oyaguchi Kami, Itabashi, Tokyo, Japan
    J Mol Med (Berl) 92:509-21. 2014
    ..The designed PI polyamide that targeted ABCA1 successfully increased ABCA1 expression and HDL biogenesis. This novel gene-regulating agent is promising as a useful compound to increase plasma HDL concentration...
  27. pmc Obesity alters the expression profile of clock genes in peripheral blood mononuclear cells
    Kazunobu Tahira
    Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Arch Med Sci 7:933-40. 2011
    ..The aim of this study was to investigate the association between the variation in expression profile of clock genes and obesity using peripheral blood mononuclear (PMN) cells...
  28. doi request reprint Moderate low temperature preserves the stemness of neural stem cells and suppresses apoptosis of the cells via activation of the cold-inducible RNA binding protein
    Kosuke Saito
    Division of Life Science, Advanced Research Institute of the Sciences and Humanities, Nihon University Graduate School, Tokyo, Japan
    Brain Res 1358:20-9. 2010
    ....
  29. doi request reprint Implantation of dedifferentiated fat cells ameliorates habu snake venom-induced chronic renal dysfunction in tenascin-C-deficient mice
    Renaguli Nur
    Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Nihon University, Tokyo, Japan
    Nephron Exp Nephrol 110:e91-8. 2008
    ..In this study, we evaluated the effect of implantation of DFAT cells on habu snake venom (HSV)-induced renal dysfunction in tenascin-C knockout (TC-KO) mice...
  30. ncbi request reprint [Basic research for cardiovascular regeneration]
    Taro Matsumoto
    Division of Cell Regeneration and Transplantation, Advanced Medical Research Center, Nihon University School of Medicine
    Nihon Rinsho 64:547-51. 2006
  31. ncbi request reprint Paraoxonase1 polymorphism Leu-Met55 is associated with cerebral infarction in Japanese population
    Takahiro Ueno
    2nd Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
    Med Sci Monit 9:CR208-12. 2003
    ..We examined whether these polymorphisms relates with the incidence of cerebral infarction (CI) which is one of the major atherosclerotic disease in Japan...
  32. ncbi request reprint Hyperglycemia and lipopolysaccharide decrease depression effect of interleukin 8 production by hypothermia: an experimental study with endothelial cells
    Akihiro Noda
    Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Itabashi ku, Tokyo 173 8610, Japan
    Intensive Care Med 34:109-15. 2008
    ..This study assessed whether hyperglycemia and lipopolysaccharide (LPS) decrease the depression effect of interleukin (IL) 8 production by hypothermia in endothelial cells...
  33. ncbi request reprint Ubiquitin-positive foam cells are identified in the aortic and mitral valves with atherosclerotic involvement
    Tsutomu Yamada
    Department of Pathology, Nihon University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 16:472-9. 2009
    ....
  34. ncbi request reprint Postprandial plasma lipid levels are influenced by the interaction of functional polymorphisms in the microsome triglyceride transfer protein and beta3 adrenergic receptor genes
    Takahiro Ueno
    Department of Medicine, Division of Nephrology and Endocrinology, Nihon University School of Medicine, Tokyo, Japan
    Med Sci Monit 13:BR112-8. 2007
    ..The effects of polymorphisms in the genes encoding microsome triglycerides transfer protein (MTP) and beta3-adrenergic receptor (beta3-AR) on lipid and glucose metabolism were investigated...
  35. doi request reprint Current status of drug therapies for osteoporosis and the search for stem cells adapted for bone regenerative medicine
    Yoshikazu Mikami
    Department of Pathology, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo, 101 8310, Japan
    Anat Sci Int 89:1-10. 2014
    ....
  36. ncbi request reprint Development of angiogenic cell and gene therapy by transplantation of umbilical cord blood with vascular endothelial growth factor gene
    Yukihiro Ikeda
    Second Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
    Hypertens Res 27:119-28. 2004
    ....
  37. ncbi request reprint The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration
    Kristina Holmqvist
    Department of Medical Cell Biology, Uppsala University, Uppsala 75123, Sweden
    J Biol Chem 279:22267-75. 2004
    ..This is achieved by Shb binding to tyrosine 1175 in the VEGFR-2, which regulates VEGF-induced formation of focal adhesions and cell migration, of which the latter occurs in a phosphatidylinositol 3-kinase-dependent manner...
  38. pmc VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis
    Taro Matsumoto
    Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
    EMBO J 24:2342-53. 2005
    ..Tumor vascularization and growth was reduced in TSAd-deficient mice, indicating a critical role of Y951-TSAd signaling in pathological angiogenesis...
  39. ncbi request reprint Endostatin regulates endothelial cell adhesion and cytoskeletal organization
    Johan Dixelius
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, 751 85 Uppsala, Sweden
    Cancer Res 62:1944-7. 2002
    ..These data provide a molecular basis both for the lack of effect of endostatin on the normal, quiescent vasculature, and its antagonistic effects on stimulated tumor vessels...
  40. pmc p38 MAP kinase negatively regulates endothelial cell survival, proliferation, and differentiation in FGF-2-stimulated angiogenesis
    Taro Matsumoto
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, S 751 85, Sweden
    J Cell Biol 156:149-60. 2002
    ..These results implicate p38 in organization of new vessels and suggest that p38 is an essential regulator of FGF-2-driven angiogenesis...
  41. ncbi request reprint VEGF-receptor signal transduction
    Michael J Cross
    Department of Genetics and Pathology, Dag Hammarskjöldsväg 20, 751 85 Uppsala, Sweden
    Trends Biochem Sci 28:488-94. 2003
    ..More recent data indicate essential roles for the VEGFs in haematopoietic cell function and in lymphangiogenesis...
  42. ncbi request reprint [Dyslipidemia in renal failure]
    Takayuki Fujioka
    Second Department of Internal Medicine, Nihon University School of Medicine
    Nihon Rinsho 62:118-23. 2004
  43. ncbi request reprint Body distribution of trace elements in black-tailed gulls from Rishiri Island, Japan: age-dependent accumulation and transfer to feathers and eggs
    Tetsuro Agusa
    Center for Marine Environmental Studies, Ehime University, Bunkyo cho 2 5, Matsuyama 790 8577, Japan
    Environ Toxicol Chem 24:2107-20. 2005
    ..To our knowledge, this is the first report on the maternal transfer rate of multielements and also on the usefulness of feathers to estimate contamination status of Hg in birds on a population basis...
  44. ncbi request reprint Proteomic analysis of vascular endothelial growth factor-induced endothelial cell differentiation reveals a role for chloride intracellular channel 4 (CLIC4) in tubular morphogenesis
    Svante Bohman
    Department of Genetics and Pathology, Uppsala University, Dag Hammarskjölds väg 20, S 751 85 Uppsala, Sweden
    J Biol Chem 280:42397-404. 2005
    ..Antisense- and small interfering RNA-mediated suppression of CLIC4 expression led to arrest in tubular morphogenesis. Our data implicate CLIC4 in formation of a vessel lumen...
  45. ncbi request reprint Digoxin inhibits neuroblastoma tumor growth in mice
    Asa Svensson
    Department of Medical Cell Biology, Children s Hospital, Uppsala University, Sweden
    Anticancer Res 25:207-12. 2005
    ..Epidemiological data suggest a more favorable outcome of breast carcinoma in women taking cardiac glycosides. This study investigated whether digoxin could inhibit tumor growth in mice...