Research Topics
| H KushiSummaryAffiliation: Nihon University Country: Japan Publications
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Detail Information
Publications
Neuronal damage in pericontusional edema zoneH Kushi
Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, Tokyo, Japan
Acta Neurochir Suppl 86:339-42. 2003..The PEZ is thought to be due to microvascular disturbance by neutrophils stimulated by inflammatory cytokines, and neuronal damage from migrated neutrophils...
Acute subdural hematoma because of boxingHidehiko Kushi
Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, Itabashi ku, Tokyo, Japan
J Trauma 66:298-303. 2009..To identify factors determining the clinical characteristics and prognosis of acute subdural hematoma (ASDH) arising from boxing injuries by comparing with ASDH due to any nonboxing cause...- Criteria for direct hemoperfusion with an immobilized polymyxin B fiber column based on oxygen metabolismHidehiko Kushi
Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, Tokyo, Japan
Ther Apher Dial 12:292-7. 2008..Based on these results, DHP-PMX should be introduced during the period when VO(2)I is still equal to or greater than 100 mL/min/m(2)... - Early hemoperfusion with a polymyxin b column improves gastric intramucosal pH in sepsisHidehiko Kushi
Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, Tokyo, Japan
Ther Apher Dial 12:278-84. 2008..Because this was a prospective uncontrolled observational study on a limited number of patients, larger multicenter clinical trials are required to more accurately assess the benefits of DHP-PMX... - Hemoperfusion with an immobilized polymyxin B fiber column improves tissue oxygen metabolismHidehiko Kushi
Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, Tokyo, Japan
Ther Apher Dial 10:430-5. 2006..8 mm Hg (P = 0.046) at 48 h, and 11 +/- 2.2 mm Hg (P = 0.045) at 72 h afterward, showing a significant decrease from 48 h onward compared with before treatment. These findings suggest that DHP-PMX improves tissue oxygen metabolism... - Hemoperfusion with an immobilized polymyxin B fiber column reduces circulating interleukin-8 concentrationsHidehiko Kushi
Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, Tokyo, Japan
Ther Apher Dial 10:425-9. 2006..0 +/- 0.9 at 72 h afterward, showing a significant decrease compared with before treatment (P < 0.05). The present findings indicate that DHP-PMX indirectly reduces circulating interleukin-8 concentration and improves SOFA score... - Hemoperfusion with an immobilized polymyxin B column reduces the blood level of neutrophil elastaseHidehiko Kushi
Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, Tokyo, Japan
Blood Purif 24:212-7. 2006..We investigated whether direct hemoperfusion with an immobilized polymyxin B column (DHP with PMX) could reduce the blood level of neutrophil elastase... 
Early hemoperfusion with an immobilized polymyxin B fiber column eliminates humoral mediators and improves pulmonary oxygenationHidehiko Kushi
Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Tokyo, 173 8610, Japan
Crit Care 9:R653-61. 2005....- Hemoperfusion with an immobilized polymyxin B fiber column inhibits activation of vascular endothelial cellsHidehiko Kushi
Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, Tokyo, Japan
Ther Apher Dial 9:303-7. 2005..0 ng/mL at 48 h after, and 64+/-18.3 ng/mL 72 h after. The values were significantly lower from 48 h onward compared with baseline. These data suggest that DHP with PMX inhibits vascular endothelial cell activation... - IL-8 is a key mediator of neuroinflammation in severe traumatic brain injuriesH Kushi
Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, Tokyo, Japan
Acta Neurochir Suppl 86:347-50. 2003..The fact that CSF IL-8 was 1000 times that in the peripheral blood at the time of admission, and decreased thereafter, indicates that IL-8 is a key mediator of neuroinflammation... - Hemoperfusion with a polymyxin B fiber column decreases clotting activityHidehiko Kushi
Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, Surugadai, Chiyoda ku, Tokyo 101 8306, Japan
Ther Apher Dial 13:528-33. 2009..This coagulation/fibrinolysis imbalance was improved by DHP-PMX. The present results suggest that indirect inhibition of clotting activity can be achieved in patients with sepsis through adsorption of lipopolysaccharide by DHP-PMX... - The risk factors for the occurrence of acute brain swelling in acute subdural hematomaT Saito
Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, Tokyo, Japan
Acta Neurochir Suppl 86:351-4. 2003..Conspicuous hypertension before the surgery was shown to be a possible risk factor for ABS. Therefore; MAP > or = 140 mmHg may be a warning sign for the occurrence of ABS... - Characteristics of parietal-parasagittal hemorrhage after mild or moderate traumatic brain injuryK Kinoshita
Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, Tokyo, Japan
Acta Neurochir Suppl 86:343-6. 2003..DISCUSSION: The incidence of parietal-parasagittal TICH is low, but the risk of neurological deterioration due to hematoma enlargement is significantly high. Parietal-parasagittal TICH may differ clinically from frontal-temporal TICH... - Risk factors for intraoperative hypotension in traumatic intracranial hematomaKosaku Kinoshita
Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, 30 1, Oyaguchi Kamimachi, Itabashi ku, Tokyo 173 8610, Japan
Resuscitation 60:151-5. 2004..We concluded that an important factor in the occurrence of IHT was not only the injury severity, but also the balance between sympathetic and parasympathetic activity before decompression surgery...