Minoru Ikeda

Summary

Affiliation: Nihon University
Country: Japan

Publications

  1. ncbi request reprint Causative factors of taste disorders in the elderly, and therapeutic effects of zinc
    M Ikeda
    Department of Otolaryngology Head and Neck Surgery, Nihon University School of Medicine, Tokyo, Japan
    J Laryngol Otol 122:155-60. 2008
  2. ncbi request reprint Facial nerve paralysis caused by middle ear cholesteatoma and effects of surgical intervention
    Minoru Ikeda
    Department of Otolaryngology, Nihon University School of Medicine, Oyaguchi Kamimachi, Tokyo, Japan
    Acta Otolaryngol 126:95-100. 2006
  3. ncbi request reprint Clinical factors that influence the prognosis of facial nerve paralysis and the magnitudes of influence
    Minoru Ikeda
    Department of Otolaryngology, Nihon University School of Medicine, Tokyo, Japan
    Laryngoscope 115:855-60. 2005
  4. ncbi request reprint Canal wall down tympanoplasty with canal reconstruction for middle-ear cholesteatoma: post-operative hearing, cholesteatoma recurrence, and status of re-aeration of reconstructed middle-ear cavity
    Minoru Ikeda
    Department of Otolaryngology, Nihon University School of Medicine, Tokyo, Japan
    J Laryngol Otol 117:249-55. 2003
  5. ncbi request reprint To what extent do evaluations of facial paralysis by physicians coincide with self-evaluations by patients: comparison of the Yanagihara method, the House-Brackmann method, and self-evaluation by patients
    Minoru Ikeda
    Department of Otolaryngology, Nihon University School of Medicine, Tokyo, Japan
    Otol Neurotol 24:334-8. 2003
  6. ncbi request reprint Use of digital subtraction fluoroscopy to diagnose radiolucent aspirated foreign bodies in infants and children
    M Ikeda
    Department of Otolaryngology, Nihon University School of Medicine, 30 1 Oyaguchi, Itabashi ku, Tokyo 173 8610, Japan
    Int J Pediatr Otorhinolaryngol 61:233-42. 2001
  7. ncbi request reprint Taste disorders: a survey of the examination methods and treatments used in Japan
    Minoru Ikeda
    Department of Otorhinolaryngology, Nihon University School of Medicine, Tokyo, Japan
    Acta Otolaryngol 125:1203-10. 2005
  8. doi request reprint Laryngeal preservation in advanced piriform sinus squamous cell carcinomas using superselective intra-arterial chemoradiation therapy with three agents
    Tohru Furusaka
    Department of Otolaryngology Head and Neck Surgery, Nihon University School of Medicine, Tokyo, Japan
    Acta Otolaryngol 133:318-26. 2013
  9. doi request reprint Concurrent chemoradiation therapy with docetaxel (DOC) for laryngeal preservation in T2N0M0 glottic squamous cell carcinomas
    Tohru Furusaka
    Department of Otolaryngology Head and Neck Surgery, Nihon University School of Medicine, Tokyo, Japan
    Acta Otolaryngol 133:99-112. 2013
  10. doi request reprint A zinc-containing compound, Polaprezinc, is effective for patients with taste disorders: randomized, double-blind, placebo-controlled, multi-center study
    Masafumi Sakagami
    Department of Otolaryngology, Hyogo College of Medicine, Hyogo, Japan
    Acta Otolaryngol 129:1115-20. 2009

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Causative factors of taste disorders in the elderly, and therapeutic effects of zinc
    M Ikeda
    Department of Otolaryngology Head and Neck Surgery, Nihon University School of Medicine, Tokyo, Japan
    J Laryngol Otol 122:155-60. 2008
    ..To determine the characteristics of causative factors of taste disorders amongst the elderly, and to examine the therapeutic effect of a zinc agent, taking into account age-related factors...
  2. ncbi request reprint Facial nerve paralysis caused by middle ear cholesteatoma and effects of surgical intervention
    Minoru Ikeda
    Department of Otolaryngology, Nihon University School of Medicine, Oyaguchi Kamimachi, Tokyo, Japan
    Acta Otolaryngol 126:95-100. 2006
    ..The outcome of facial paralysis was good. Poor outcomes were observed in cases with petrosal cholesteatoma and in those who underwent surgery > or = 2 months after the onset of paralysis...
  3. ncbi request reprint Clinical factors that influence the prognosis of facial nerve paralysis and the magnitudes of influence
    Minoru Ikeda
    Department of Otolaryngology, Nihon University School of Medicine, Tokyo, Japan
    Laryngoscope 115:855-60. 2005
    ..To show the significance of various factors when predicting the outcome of facial nerve paralysis...
  4. ncbi request reprint Canal wall down tympanoplasty with canal reconstruction for middle-ear cholesteatoma: post-operative hearing, cholesteatoma recurrence, and status of re-aeration of reconstructed middle-ear cavity
    Minoru Ikeda
    Department of Otolaryngology, Nihon University School of Medicine, Tokyo, Japan
    J Laryngol Otol 117:249-55. 2003
    ..It was revealed that the post-operative outcome of this surgical technique was significantly related to the state of re-aeration of the reconstructed middle-ear cavity...
  5. ncbi request reprint To what extent do evaluations of facial paralysis by physicians coincide with self-evaluations by patients: comparison of the Yanagihara method, the House-Brackmann method, and self-evaluation by patients
    Minoru Ikeda
    Department of Otolaryngology, Nihon University School of Medicine, Tokyo, Japan
    Otol Neurotol 24:334-8. 2003
    ..To understand to what extent evaluations of facial paralysis by physicians coincide with self-evaluations by patients...
  6. ncbi request reprint Use of digital subtraction fluoroscopy to diagnose radiolucent aspirated foreign bodies in infants and children
    M Ikeda
    Department of Otolaryngology, Nihon University School of Medicine, 30 1 Oyaguchi, Itabashi ku, Tokyo 173 8610, Japan
    Int J Pediatr Otorhinolaryngol 61:233-42. 2001
    ..This can result in delay of diagnosis or misdiagnosis of foreign body aspiration. We report the usefulness and pitfalls of use of digital subtraction fluoroscopy (DSF) to diagnose radiolucent aspirated foreign bodies in infants...
  7. ncbi request reprint Taste disorders: a survey of the examination methods and treatments used in Japan
    Minoru Ikeda
    Department of Otorhinolaryngology, Nihon University School of Medicine, Tokyo, Japan
    Acta Otolaryngol 125:1203-10. 2005
    ..Taste examinations are routinely conducted in almost all university hospitals; testing is not as common in private clinics. Administration of zinc is the main treatment for taste disorders in Japan...
  8. doi request reprint Laryngeal preservation in advanced piriform sinus squamous cell carcinomas using superselective intra-arterial chemoradiation therapy with three agents
    Tohru Furusaka
    Department of Otolaryngology Head and Neck Surgery, Nihon University School of Medicine, Tokyo, Japan
    Acta Otolaryngol 133:318-26. 2013
    ..Superselective intra-arterial chemotherapy, which enables local control and laryngeal preservation, is a safe and useful therapy for preservation of nutrition, speech, and swallowing functions...
  9. doi request reprint Concurrent chemoradiation therapy with docetaxel (DOC) for laryngeal preservation in T2N0M0 glottic squamous cell carcinomas
    Tohru Furusaka
    Department of Otolaryngology Head and Neck Surgery, Nihon University School of Medicine, Tokyo, Japan
    Acta Otolaryngol 133:99-112. 2013
    ..Concurrent chemoradiation therapy with docetaxel (DOC) at a dose of 10 mg/m(2) twice a week contributed to laryngeal preservation...
  10. doi request reprint A zinc-containing compound, Polaprezinc, is effective for patients with taste disorders: randomized, double-blind, placebo-controlled, multi-center study
    Masafumi Sakagami
    Department of Otolaryngology, Hyogo College of Medicine, Hyogo, Japan
    Acta Otolaryngol 129:1115-20. 2009
    ..The effect of a zinc-containing compound, Polaprezinc, was shown to clinically improve the disease conditions of idiopathic taste disorders with no serious side effects in a well controlled double-blinded clinical study...
  11. doi request reprint Superselective intra-arterial chemoradiation therapy for functional laryngeal preservation in advanced squamous cell carcinoma of the glottic larynx
    Tohru Furusaka
    Department of Otolaryngology Head and Neck Surgery, Nihon University School of Medicine, Tokyo, Japan
    Acta Otolaryngol 133:633-40. 2013
    ....
  12. doi request reprint Long-term follow-up and salvage surgery in patients with T2N0M0 squamous cell carcinoma of the glottic larynx following concurrent chemoradiation therapy with cisplatin and 5-fluorouracil for laryngeal preservation
    Tohru Furusaka
    Department of Otolaryngology Head and Neck Surgery, Nihon University School of Medicine, Tokyo, Japan
    Acta Otolaryngol 133:91-8. 2013
    ..5%, 95.3%, and 75.1%, respectively. Statistically, concurrent chemoradiation therapy contributes to laryngeal preservation but not to the survival rate...
  13. ncbi request reprint [The effect of zinc agent in 219 patients with zinc deficiency-inductive/ idiopathic taste disorder: a placebo controlled randomized study]
    Minoru Ikeda
    Department of Otolaryngology Head and Neck Surgery, Nihon University School of Medicine
    Nihon Jibiinkoka Gakkai Kaiho 116:17-26. 2013
    ....
  14. doi request reprint Long-term follow-up and salvage surgery in patients with T2N0M0 squamous cell carcinoma of the glottic larynx who received concurrent chemoradiation therapy with carboplatin (CBDCA) - AUC 1.5 vs AUC 2.0
    Tohru Furusaka
    Department of Otolaryngology Head and Neck Surgery, Nihon University School of Medicine, Tokyo, Japan
    Acta Otolaryngol 132:1215-23. 2012
    ..0 mg/ml, the complete response (CR), 10-year survival, and 10-year larynx preservation rates were 96.0%, 91.1%, and 75.2%, respectively, and the safety margin for partial laryngectomy was 4 mm from the gross tumor...
  15. ncbi request reprint Efficacy of multidrug superselective intra-arterial chemotherapy (docetaxel, cisplatin, and 5-fluorouracil) using the Seldinger technique for tongue cancer
    Tohru Furusaka
    Department of Otolaryngology Head and Neck Surgery, School of Medicine, Nihon University, Itabashi ku, Tokyo, Japan
    Acta Otolaryngol 132:1108-14. 2012
    ..Cervical lymph node metastasis was treated with neck dissection in some patients. The results indicate that this therapy is useful to control primary tumor without resection for organ preservation...
  16. pmc A mutation at IVS1 + 5 of the von Hippel-Lindau gene resulting in intron retention in transcripts is not pathogenic in a patient with a tongue cancer?: case report
    Takeshi Asakawa
    Department of Otorhinolaryngology Head and Neck Surgery, Nihon University School of Medicine, Tokyo 173 8610, Japan
    BMC Med Genet 13:23. 2012
    ..Previously, we reported that the loss of heterozygosity (LOH) of the VHL gene is common in squamous cell carcinoma tissues of the tongue...
  17. doi request reprint Multidrug resistance in mucoepidermoid carcinoma of the parotid gland--immunohistochemical investigations of P-glycoprotein expression
    Tohru Furusaka
    Department of Otolaryngology Head and Neck Surgery, Nihon University School of Medicine, Itabashi ku, Tokyo, Japan
    Acta Otolaryngol 133:552-7. 2013
    ..The tumor size-related difference in P-glycoprotein expression was only significant for staining with one antibody, and no significant differences were observed with or without induction chemotherapy...
  18. doi request reprint Superselective intra-arterial chemotherapy for laryngeal preservation in carcinoma of the anterior oropharyngeal wall
    Tohru Furusaka
    Department of Otolaryngology Head and Neck Surgery, Nihon University School of Medicine, Tokyo, Japan
    Acta Otolaryngol 133:194-202. 2013
    ..Superselective intra-arterial chemotherapy, which can provide local control and laryngeal preservation, is safe and useful for preserving pharyngeal and laryngeal functions...
  19. ncbi request reprint Patients with phantogeusia show increased expression of T2R taste receptor genes in their tongues
    Ryoji Hirai
    Department of Otolaryngology Head and Neck Surgery, Nihon University School of Medicine, Tokyo, Japan
    Ann Otol Rhinol Laryngol 121:113-8. 2012
    ..Phantogeusia is a spontaneous abnormal taste with no external stimulus. We analyzed the expression of T2R taste receptor genes in the tongues of patients with phantogeusia to assess their role in the pathogenesis of phantogeusia...
  20. ncbi request reprint A high-concentration NaCl solution does not stimulate the human trigeminal nerve at the tip of the tongue
    Ayako Komiyama
    Department of Otolaryngology, Nihon University School of Medicine, Tokyo
    Acta Otolaryngol 127:754-9. 2007
    ..4 M or greater. We have attempted to clarify whether or not relatively high concentrations of NaCl stimulate the trigeminal nerves of the human tongue...
  21. ncbi request reprint Expression and localization of taste receptor genes in the vallate papillae of rats: effect of zinc deficiency
    Atsuo Ikeda
    Department of Otolaryngology Head and Neck Surgery, Tokyo, Japan
    Acta Otolaryngol 133:957-64. 2013
    ..These findings suggest that decreased expression of taste receptor genes may play an important role in the onset of zinc deficiency-associated taste disorder...
  22. doi request reprint Effects of zinc deficiency and supplementation on gene expression of bitter taste receptors (TAS2Rs) on the tongue in rats
    Hiroki Sekine
    Department of Otolaryngology Head and Neck Surgery, Zeria Pharmaceutical Company, Ltd, Saitama, Japan
    Laryngoscope 122:2411-7. 2012
    ..We examined the effect of zinc deficiency and supplementation on the expression of bitter taste receptor (TAS2R) and epithelial sodium ion channel (ENaC) genes on the tongue in rats...
  23. doi request reprint Patients with hypogeusia show changes in expression of T2R taste receptor genes in their tongues
    Keiko Onoda
    Department of Otolaryngology Head and Neck Surgery, Nihon University School of Medicine, Tokyo, Japan
    Laryngoscope 121:2592-7. 2011
    ..In this study, we compared the expression of genes of the T2R family in the tongues of patients with hypogeusia to those in healthy subjects and examined the possibility that T2R genes are involved in the pathogenesis of hypogeusia...
  24. doi request reprint Assessment of human papilloma virus infection in adult laryngeal papilloma using a screening test
    Kiyoshi Makiyama
    Department of Otorhinolaryngology, Nihon University Surugadai Hospital, Chiyoda, Tokyo 101 8309, Japan
    J Voice 27:230-5. 2013
    ..We hypothesized that multiple-site and recurrent papillomas would have a strong relationship to HPV and conducted the present study to test this hypothesis...
  25. ncbi request reprint [An assessment of psychological stress in patients with facial palsy]
    Mutsumi Sugiura
    Department of Otolaryngology, Tokyo Metropolitan Geriatric Hospital, Tokyo
    Nihon Jibiinkoka Gakkai Kaiho 106:491-8. 2003
    ..Facial palsy may cause excessive stress due to the obviousness of its manifestations. We evaluated psychological stress in patients with facial palsy...
  26. ncbi request reprint Cefaclor concentration in radicular granuloma after a single oral administration
    Y Akimoto
    Department of Oral Surgery, Nihon University School of Dentistry at Matsudo, Chiba, Japan
    Gen Pharmacol 31:283-5. 1998
    ..35. 3. All cefaclor concentrations in radicular granuloma at the peak time exceeded the minimal inhibitory concentration for 90% of oral streptococci (1 mcg/ml) isolated from odontogenic infection...
  27. ncbi request reprint Why do patients with fibromyalgia complain of ear-related symptoms? Ear-related symptoms and otological findings in patients with fibromyalgia
    Fusako Iikuni
    Department of Otolaryngology Head and Neck Surgery, Nihon University School of Medicine, 30 1, Oyaguchi kamicho, Itabashi ku, Tokyo, 173 8610, Japan
    Clin Rheumatol 32:1437-41. 2013
    ..Given our findings, we suspect that onset of ear fullness may be associated not with abnormal findings in the middle and inner ear function tests but with other causes, such as central desensitization. ..
  28. ncbi request reprint Pharyngeal squamous cell papilloma in adult Japanese: comparison with laryngeal papilloma in clinical manifestations and HPV infection
    Ryoji Hirai
    Department of Otolaryngology Head and Neck Surgery, Nihon University School of Medicine, 30 1 Oyaguchi kamicho, Itabashi ku, Tokyo 173 8610, Japan
    Eur Arch Otorhinolaryngol 269:2271-6. 2012
    ..Pharyngeal papilloma occurred as a solitary lesion in females more frequently. Contrary to our hypothesis, the involvement of HPV infection was unlikely in the occurrence of pharyngeal papilloma...
  29. ncbi request reprint Laterality of human primary gustatory cortex studied by MEG
    Keiko Onoda
    Department of Otolaryngology, Nihon University School of Medicine, 30 1 Oyaguchi kamicho, Itabashi ku, Tokyo 173 8610, Japan
    Chem Senses 30:657-66. 2005
    ..These results suggest that unilateral gustatory stimulation will activate the transitional cortex between the insula and the parietal operculum bilaterally in humans...
  30. doi request reprint Long-term observations and salvage operations on patients with T2N0M0 squamous cell carcinoma of the glottic larynx treated with radiation therapy alone
    Tohru Furusaka
    Department of Otolaryngology Head and Neck Surgery, Nihon University School of Medicine, Tokyo, Japan
    Acta Otolaryngol 132:546-51. 2012
    ..Thirty-four patients underwent salvage operations and a safe margin for the partial laryngectomy was evaluated by histopathological examination of serial sections of the surgical specimen...
  31. ncbi request reprint p53 mutation, but not in vitro predictor genes of therapeutic efficacy of cisplatin, is clinically relevant in comparing partial and complete responder cases of maxillary squamous cell carcinoma
    Itsuhiro Kudo
    Department of Otorhinolaryngology Head and Neck Surgery, Nihon University School of Medicine, Itabashi ku, Tokyo 173 8610, Japan
    Oncol Rep 24:851-6. 2010
    ..In responder cases, the drug-resistant genes that were determined in cell lines by culture do not necessarily translate into clinical relevance...
  32. ncbi request reprint Tongue cancer patients have a high frequency of allelic loss at the von Hippel-Lindau gene and other loci on 3p
    Takeshi Asakawa
    Department of Otolaryngology Head and Neck Surgery, Nihon University School of Medicine, Japan
    Cancer 112:527-34. 2008
    ..In addition, the coding region of the intact VHL allele was screened for sequence mutations...
  33. ncbi request reprint Optokinetic nystagmus and after-nystagmus during a 6 hour bedrest study
    Kazue Hida
    Department of Otolaryngology Head and Neck Surgery, Nihon University School of Medicine, Tokyo, Japan
    Acta Otolaryngol 128:761-7. 2008
    ..A lengthy alteration of gravity direction produced different effects on the intrinsic horizontal and vertical optokinetic oculomotor systems...
  34. ncbi request reprint Phase I trial of gemcitabine in patients with advanced pancreatic cancer
    S Okada
    Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    Jpn J Clin Oncol 31:7-12. 2001
    ..CONCLUSION: Gemcitabine 1000 mg/m2 weekly x7 followed by a week of rest and weekly x3 every 4 weeks thereafter may be tolerated in Japanese patients with advanced pancreatic cancer...
  35. ncbi request reprint Optimal initial dose of orally administered cyclosporine following intravenous cyclosporine therapy
    T Ishizawa
    Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Transplant Proc 37:4370-2. 2005
    ....
  36. ncbi request reprint The salivary protein profiles in the patients with taste disorders: the comparison of salivary protein profiles by two-dimensional gel electrophoresis between the patients with taste disorders and healthy subjects
    Atsuko Igarashi
    Clin Chim Acta 388:204-6. 2008
  37. ncbi request reprint Measurements of several metallic elements and matrix metalloproteinases (MMPs) in saliva from patients with taste disorder
    Mamoru Watanabe
    Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Chem Senses 30:121-5. 2005
    ..8 (P < 0.049). These differences may be closely related with this disease. ICP-MS is an easy and accurate instrument for measurements of salivary metallic elements and may be useful in establishing a diagnosis of taste disorder...