Affiliation: National Institute of Advanced Industrial Science and Technology
Yoshida Y, Hayakawa M, Niki E. Evaluation of the antioxidant effects of coffee and its components using the biomarkers hydroxyoctadecadienoic acid and isoprostane. J Oleo Sci. 2008;57:691-7 pubmed
Yoshida Y, Hayakawa M, Niki E. Total hydroxyoctadecadienoic acid as a marker for lipid peroxidation in vivo. Biofactors. 2005;24:7-15 pubmed
..It was found that the administration of free radical-generating azo compound increased the level of HODE and decreased the (Z, E)-HODE/(E, E)-HODE ratio in both plasma and liver. The level of HODE was much higher than 8-isoprostane. ..
Yoshida Y, Hayakawa M, Cynshi O, Jishage K, Niki E. Acceleration of lipid peroxidation in alpha-tocopherol transfer protein-knockout mice following the consumption of drinking water containing a radical initiator. J Oleo Sci. 2008;57:577-83 pubmed
..It was clearly demonstrated by the proposed biomarkers that maintaining alpha-TTP(-/-) mice on a VE-deficient diet results in a severe VE deficiency and promotes lipid peroxidation. ..
Yoshida Y, Niki E, Noguchi N. Comparative study on the action of tocopherols and tocotrienols as antioxidant: chemical and physical effects. Chem Phys Lipids. 2003;123:63-75 pubmed
Yoshida Y, Niki E. Antioxidant effects of alpha- and gamma-carboxyethyl-6-hydroxychromans. Biofactors. 2002;16:93-103 pubmed
..These results imply that CEHC may act as an antioxidant in vivo especially for those who take tocopherol supplement. ..
Yoshida Y, Yoshikawa A, Kinumi T, Ogawa Y, Saito Y, Ohara K, et al
. Hydroxyoctadecadienoic acid and oxidatively modified peroxiredoxins in the blood of Alzheimer's disease patients and their potential as biomarkers. Neurobiol Aging. 2009;30:174-85 pubmed
..These data further support that oxidative stress is indeed involved in AD and that the correlative measures of tHODE and oxPrx are potential biomarkers for its diagnosis. ..
Yoshida Y, Hayakawa M, Habuchi Y, Itoh N, Niki E. Evaluation of lipophilic antioxidant efficacy in vivo by the biomarkers hydroxyoctadecadienoic acid and isoprostane. Lipids. 2007;42:463-72 pubmed
Yoshida Y, Kodai S, Takemura S, Minamiyama Y, Niki E. Simultaneous measurement of F2-isoprostane, hydroxyoctadecadienoic acid, hydroxyeicosatetraenoic acid, and hydroxycholesterols from physiological samples. Anal Biochem. 2008;379:105-15 pubmed publisher
..t8-iso-PGF(2alpha), tHODE, tHETE, and t7-OHCh are measured satisfactorily and inclusively by the current method from biological fluids and tissues, and they can account for a large portion of oxidized lipids in vivo. ..
Umeno A, Horie M, Murotomi K, Nakajima Y, Yoshida Y. Antioxidative and Antidiabetic Effects of Natural Polyphenols and Isoflavones. Molecules. 2016;21: pubmed publisher
..Appropriate analytical approaches for evaluating antioxidants in studies on the prevention of diabetes are comprehensively reviewed. ..