Yasukazu Yoshida

Summary

Affiliation: National Institute of Advanced Industrial Science and Technology
Country: Japan

Publications

  1. pmc Singlet oxygen induced products of linoleates, 10- and 12-(Z,E)-hydroxyoctadecadienoic acids (HODE), can be potential biomarkers for early detection of type 2 diabetes
    Aya Umeno
    National Institute of Advanced Industrial Science and Technology, Takamatsu, Kagawa, Japan
    PLoS ONE 8:e63542. 2013
  2. pmc Lipid peroxidation biomarkers for evaluating oxidative stress and assessing antioxidant capacity in vivo
    Yasukazu Yoshida
    Health Research Institute HRI, National Institute of Advanced Industrial Science and Technology AIST, 2217 14 Hayashi Cho, Takamatsu, Kagawa 761 0395, Japan
    J Clin Biochem Nutr 52:9-16. 2013
  3. ncbi request reprint Action of DCFH and BODIPY as a probe for radical oxidation in hydrophilic and lipophilic domain
    Yasukazu Yoshida
    Human Stress Signal Research Center HSSRC, National Institute of Advanced Industrial Science and Technology AIST, Ikeda, Osaka 563 8577, Japan
    Free Radic Res 37:861-72. 2003
  4. doi request reprint Simultaneous measurement of F2-isoprostane, hydroxyoctadecadienoic acid, hydroxyeicosatetraenoic acid, and hydroxycholesterols from physiological samples
    Yasukazu Yoshida
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 563 8577, Japan
    Anal Biochem 379:105-15. 2008
  5. ncbi request reprint Lipid peroxidation induced by carbon tetrachloride and its inhibition by antioxidant as evaluated by an oxidative stress marker, HODE
    Yasukazu Yoshida
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology AIST, 1 8 31 Midorigaoka Ikeda, Osaka 563 8577, Japan
    Toxicol Appl Pharmacol 208:87-97. 2005
  6. doi request reprint Hydroxyoctadecadienoic acid as a potential biomarker for oxidative stress in patients with chronic hepatitis C
    Yasukazu Yoshida
    Health Technology Research Center, National Institute of Advanced Industrial Science and Technology, Osaka, Japan
    J Gastroenterol Hepatol 25:107-15. 2010
  7. ncbi request reprint Levels of lipid peroxidation in human plasma and erythrocytes: comparison between fatty acids and cholesterol
    Yasukazu Yoshida
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology AIST, 1 8 31 Midorigaoka, Ikeda, Osaka, Japan
    Lipids 42:439-49. 2007
  8. ncbi request reprint Total hydroxyoctadecadienoic acid as a marker for lipid peroxidation in vivo
    Yasukazu Yoshida
    National Institute of Advanced Industrial Science and Technology AIST, Human Stress Signal Research Center, Ikeda 563 8577, Japan
    Biofactors 24:7-15. 2005
  9. ncbi request reprint Antioxidant effects of 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran and alpha-tocopherol in hyperlipidemic mice as evaluated by hydroxyoctadecadienoic acid and 7-hydroxycholesterol
    Yasukazu Yoshida
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Biochem Pharmacol 74:1010-9. 2007
  10. ncbi request reprint Lipid peroxidation in mice fed a choline-deficient diet as evaluated by total hydroxyoctadecadienoic acid
    Yasukazu Yoshida
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, Osaka, Japan
    Nutrition 22:303-11. 2006

Detail Information

Publications98

  1. pmc Singlet oxygen induced products of linoleates, 10- and 12-(Z,E)-hydroxyoctadecadienoic acids (HODE), can be potential biomarkers for early detection of type 2 diabetes
    Aya Umeno
    National Institute of Advanced Industrial Science and Technology, Takamatsu, Kagawa, Japan
    PLoS ONE 8:e63542. 2013
    ..In conclusion, 10- and 12-(Z,E)-HODE may be prominent biomarkers for the early detection of IGT and "high-normal" type without OGTT...
  2. pmc Lipid peroxidation biomarkers for evaluating oxidative stress and assessing antioxidant capacity in vivo
    Yasukazu Yoshida
    Health Research Institute HRI, National Institute of Advanced Industrial Science and Technology AIST, 2217 14 Hayashi Cho, Takamatsu, Kagawa 761 0395, Japan
    J Clin Biochem Nutr 52:9-16. 2013
    ..The implications of lipid peroxidation products in vivo will be briefly reviewed and their practical applications will be discussed...
  3. ncbi request reprint Action of DCFH and BODIPY as a probe for radical oxidation in hydrophilic and lipophilic domain
    Yasukazu Yoshida
    Human Stress Signal Research Center HSSRC, National Institute of Advanced Industrial Science and Technology AIST, Ikeda, Osaka 563 8577, Japan
    Free Radic Res 37:861-72. 2003
    ....
  4. doi request reprint Simultaneous measurement of F2-isoprostane, hydroxyoctadecadienoic acid, hydroxyeicosatetraenoic acid, and hydroxycholesterols from physiological samples
    Yasukazu Yoshida
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 563 8577, Japan
    Anal Biochem 379:105-15. 2008
    ..t8-iso-PGF(2alpha), tHODE, tHETE, and t7-OHCh are measured satisfactorily and inclusively by the current method from biological fluids and tissues, and they can account for a large portion of oxidized lipids in vivo...
  5. ncbi request reprint Lipid peroxidation induced by carbon tetrachloride and its inhibition by antioxidant as evaluated by an oxidative stress marker, HODE
    Yasukazu Yoshida
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology AIST, 1 8 31 Midorigaoka Ikeda, Osaka 563 8577, Japan
    Toxicol Appl Pharmacol 208:87-97. 2005
    ..The lipophilic antioxidants such as gamma-tocopherol, gamma-tocotrienol and 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran (BO-653) were effective in suppressing the formation of HODE...
  6. doi request reprint Hydroxyoctadecadienoic acid as a potential biomarker for oxidative stress in patients with chronic hepatitis C
    Yasukazu Yoshida
    Health Technology Research Center, National Institute of Advanced Industrial Science and Technology, Osaka, Japan
    J Gastroenterol Hepatol 25:107-15. 2010
    ....
  7. ncbi request reprint Levels of lipid peroxidation in human plasma and erythrocytes: comparison between fatty acids and cholesterol
    Yasukazu Yoshida
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology AIST, 1 8 31 Midorigaoka, Ikeda, Osaka, Japan
    Lipids 42:439-49. 2007
    ..These products may be used as potential biomarker for assessment of lipid peroxidation and oxidative stress in vivo...
  8. ncbi request reprint Total hydroxyoctadecadienoic acid as a marker for lipid peroxidation in vivo
    Yasukazu Yoshida
    National Institute of Advanced Industrial Science and Technology AIST, Human Stress Signal Research Center, Ikeda 563 8577, Japan
    Biofactors 24:7-15. 2005
    ..It was found that the administration of free radical-generating azo compound increased the level of HODE and decreased the (Z, E)-HODE/(E, E)-HODE ratio in both plasma and liver. The level of HODE was much higher than 8-isoprostane...
  9. ncbi request reprint Antioxidant effects of 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran and alpha-tocopherol in hyperlipidemic mice as evaluated by hydroxyoctadecadienoic acid and 7-hydroxycholesterol
    Yasukazu Yoshida
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Biochem Pharmacol 74:1010-9. 2007
    ..In summary, it was demonstrated by biomarkers, tHODE and t7-OHCh, that the added BO-653 in their diets exerted antioxidative effects in vivo under the condition of reduced vitamin E...
  10. ncbi request reprint Lipid peroxidation in mice fed a choline-deficient diet as evaluated by total hydroxyoctadecadienoic acid
    Yasukazu Yoshida
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, Osaka, Japan
    Nutrition 22:303-11. 2006
    ..Further, the protective effects of antioxidants against oxidative damage were assessed by using HODE...
  11. ncbi request reprint Hydroxyoctadecadienoic acid and oxidatively modified peroxiredoxins in the blood of Alzheimer's disease patients and their potential as biomarkers
    Yasukazu Yoshida
    Human Stress Signal Research Center HSSRC, National Institute of Advanced Industrial Science and Technology AIST, Ikeda, Osaka 563 8577, Japan
    Neurobiol Aging 30:174-85. 2009
    ..These data further support that oxidative stress is indeed involved in AD and that the correlative measures of tHODE and oxPrx are potential biomarkers for its diagnosis...
  12. ncbi request reprint Evaluation of lipophilic antioxidant efficacy in vivo by the biomarkers hydroxyoctadecadienoic acid and isoprostane
    Yasukazu Yoshida
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology AIST, 1 8 31 Midorigaoka Ikeda, Osaka 563 8577, Japan
    Lipids 42:463-72. 2007
    ....
  13. ncbi request reprint Evaluation of the dietary effects of coenzyme Q in vivo by the oxidative stress marker, hydroxyoctadecadienoic acid and its stereoisomer ratio
    Yasukazu Yoshida
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology AIST, 1 8 31 Midorigaoka Ikeda, Osaka 563 8577, Japan
    Biochim Biophys Acta 1760:1558-68. 2006
    ....
  14. ncbi request reprint Acceleration of lipid peroxidation in alpha-tocopherol transfer protein-knockout mice following the consumption of drinking water containing a radical initiator
    Yasukazu Yoshida
    Health Technology Research Center, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka, Japan
    J Oleo Sci 57:577-83. 2008
    ..It was clearly demonstrated by the proposed biomarkers that maintaining alpha-TTP(-/-) mice on a VE-deficient diet results in a severe VE deficiency and promotes lipid peroxidation...
  15. ncbi request reprint Bio-markers of lipid peroxidation in vivo: hydroxyoctadecadienoic acid and hydroxycholesterol
    Yasukazu Yoshida
    National Institute of Advanced Industrial Science and Technology AIST, Human Stress Signal Research Center, 1 8 31 Midorigaoka, Ikeda 563 8577, Japan
    Biofactors 27:195-202. 2006
    ..In addition to this advantage, hydrogen-donor activity of antioxidants in vivo could be determined by the isomeric-ratio of HODE (9- and 13-(Z,E)-HODE/9- and 13-(E,E)-HODE)...
  16. ncbi request reprint Relative susceptibilities of linoleates and cholesterol to oxidation assessed by total hydroxyoctadecadienoic acid and 7-hydroxycholesterol
    Yasukazu Yoshida
    Human Stress Signal Research Center HSSRC, National Institute of Advanced Industrial Science and Technology AIST, Ikeda, Osaka, Japan
    J Oleo Sci 57:407-14. 2008
    ..Importantly, the oxidizability depends on the kinds of solvent, implying that the in vivo oxidation may be in part influenced by the milieu where the substrates exist...
  17. ncbi request reprint Comparative study on the action of tocopherols and tocotrienols as antioxidant: chemical and physical effects
    Yasukazu Yoshida
    Human Stress Signal Research Center HSSRC, National Institute of Advanced Industrial Science and Technology AIST, Ikeda, Osaka 563 8577, Japan
    Chem Phys Lipids 123:63-75. 2003
    ....
  18. ncbi request reprint Application of water-soluble radical initiator, 2,2'-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride, to a study of oxidative stress
    Yasukazu Yoshida
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Free Radic Res 38:375-84. 2004
    ..It may be concluded that AIPH is useful for kinetic and mechanistic studies on oxidative stress to membranes, lipoproteins, cells, and even animal models...
  19. ncbi request reprint Antioxidant effects of phytosterol and its components
    Yasukazu Yoshida
    Human Stress Signal Research Center HSSRC, National Institute of Advanced Industrial Science and Technology AIST, Midorigaoka, Ikeda, Osaka 563 8577, Japan
    J Nutr Sci Vitaminol (Tokyo) 49:277-80. 2003
    ..Taken together, the present study shows that phytosterol chemically acts as an antioxidant, a modest radical scavenger, and physically as a stabilizer in the membranes...
  20. ncbi request reprint Evaluation of the antioxidant effects of coffee and its components using the biomarkers hydroxyoctadecadienoic acid and isoprostane
    Yasukazu Yoshida
    Health Technology Research Center, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka, Japan
    J Oleo Sci 57:691-7. 2008
    ....
  21. ncbi request reprint Detection of lipid peroxidation in vivo: total hydroxyoctadecadienoic acid and 7-hydroxycholesterol as oxidative stress marker
    Yasukazu Yoshida
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, Japan 1 8 31 Midorigaoka, Ikeda, Osaka, 563 8577 Japan
    Free Radic Res 38:787-94. 2004
    ..As the concentrations of HODE were much higher than 8-iso-prostaglandin F2alpha, HODE may well be used as a good oxidative marker in vivo...
  22. doi request reprint The role of alpha-tocopherol in motor hypofunction with aging in alpha-tocopherol transfer protein knockout mice as assessed by oxidative stress biomarkers
    Yasukazu Yoshida
    Health Technology Research Center, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 563 8577, Japan
    J Nutr Biochem 21:66-76. 2010
    ....
  23. ncbi request reprint Antioxidant effects of alpha- and gamma-carboxyethyl-6-hydroxychromans
    Yasukazu Yoshida
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology AIST, 1 8 31Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Biofactors 16:93-103. 2002
    ..These results imply that CEHC may act as an antioxidant in vivo especially for those who take tocopherol supplement...
  24. doi request reprint Proteomic characterization of the striatum and midbrain treated with 6-hydroxydopamine: alteration of 58-kDa glucose-regulated protein and C/EBP homologous protein
    Yoko Ogawa Akazawa
    Health Technology Research Center, National Institute of Advanced Industrial Science and Technology AIST, Kansai Center, Ikeda, Osaka, Japan
    Free Radic Res 44:410-21. 2010
    ..Collectively, these findings suggest that ER stress involving the alteration of Grp58 and CHOP play a significant role in the induction of insults by 6-OHDA in vivo...
  25. doi request reprint Evaluation of cellular influences caused by calcium carbonate nanoparticles
    Masanori Horie
    Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health Japan, 1 1 Iseigaoka, Kitakyushu, Fukuoka 807 8555, Japan Health Research Institute HRI, National Institute of Advanced Industrial Science and Technology AIST, 1 8 31, Midorigaoka, Ikeda, Osaka 563 8577, Japan Electronic address
    Chem Biol Interact 210:64-76. 2014
    ..If inhaled CaCO₃ nanoparticles have the potential to influence cellular events. However, the effect might be not severe because calcium is omnipresent element in cell...
  26. doi request reprint Effects of ultrafine TiO2 particles on gene expression profile in human keratinocytes without illumination: involvement of extracellular matrix and cell adhesion
    Katsuhide Fujita
    Health Technology Research Center, National Institute of Advanced Industrial Science and Technology, Onogawa 16 1, Tsukuba, Ibaraki 305 8569, Japan
    Toxicol Lett 191:109-17. 2009
    ..These results suggest that the ultrafine TiO(2) particles without illumination have no significant impact on ROS-associated oxidative damage, but affect the cell-matrix adhesion in keratinocytes for extracellular matrix remodeling...
  27. doi request reprint Chromium(III) oxide nanoparticles induced remarkable oxidative stress and apoptosis on culture cells
    Masanori Horie
    Health Research Institute, National Institute of Advanced Industrial Science and Technology, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Environ Toxicol 28:61-75. 2013
    ..The cellular influences of Cr(2)O(3) nanoparticles matched those of hexavalent chromium. In conclusion, Cr(2)O(3) nanoparticles have a high cytotoxic potential...
  28. doi request reprint Identification of potential biomarkers from gene expression profiles in rat lungs intratracheally instilled with C(60) fullerenes
    Katsuhide Fujita
    Research Institute of Science for Safety and Sustainability, National Institute of Advanced Industrial Science and Technology AIST, Onogawa 16 1, Tsukuba, Ibaraki 305 8569, Japan
    Toxicology 274:34-41. 2010
    ..We propose that these genes are useful for identifying potential biomarkers in acute-phase or persistent responses to C(60) fullerenes in the lung tissue...
  29. doi request reprint Cellular responses by stable and uniform ultrafine titanium dioxide particles in culture-medium dispersions when secondary particle size was 100 nm or less
    Masanori Horie
    Health Technology Research Center HTRC, National Institute of Advanced Industrial Science and Technology AIST, Ikeda, Osaka, Japan
    Toxicol In Vitro 24:1629-38. 2010
    ..As a result, although the ultrafine TiO(2) particles induce some cellular responses, these cellular responses to ultrafine TiO(2) are weaker than those of other cytotoxic ultrafine metal oxide particles, such as nickel oxide...
  30. ncbi request reprint Evaluation of acute oxidative stress induced by NiO nanoparticles in vivo and in vitro
    Masanori Horie
    Health Research Institute, Ikeda, Osaka, Japan
    J Occup Health 53:64-74. 2011
    ..In the present study, we focused on the oxidative stress caused by NiO nanoparticles by examining and comparing in vitro and in vivo acute responses induced by NiO nanoparticles...
  31. ncbi request reprint Antioxidant action of 2,2,4,6-tetra-substituted 2,3-dihydro-5-hydroxybenzofuran against lipid peroxidation: effects of substituents and side chain
    Yasukazu Yoshida
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, Midorigaoaka, Ikeda, Osaka 563 8577, Japan
    Free Radic Res 36:1171-8. 2002
    ....
  32. ncbi request reprint Assessment of antioxidative activity of extract from fermented grain food mixture using chemical and cellular systems
    Yoko Ogawa
    Health Technology Research Center, National Institute of Advanced Industrial Science and Technology AIST, Ikeda, Osaka, Japan
    Biofactors 31:237-48. 2007
    ..This evidence suggests that AOB possesses both direct and indirect antioxidant activities to cope with oxidative insults...
  33. doi request reprint Induction of adaptive response and enhancement of PC12 cell tolerance by lipopolysaccharide primarily through the upregulation of glutathione S-transferase A3 via Nrf2 activation
    Yo Omata
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, 1 8 31, Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Free Radic Biol Med 45:1437-45. 2008
    ....
  34. doi request reprint Gamma-tocopheryl quinone, not alpha-tocopheryl quinone, induces adaptive response through up-regulation of cellular glutathione and cysteine availability via activation of ATF4
    Yoko Ogawa
    Human Stress Signal Research Center HSSRC, National Institute of Advanced Industrial Science and Technology AIST, Ikeda, Osaka, Japan
    Free Radic Res 42:674-87. 2008
    ....
  35. doi request reprint In vitro evaluation of cellular influences induced by stable fullerene C₇₀ medium dispersion: induction of cellular oxidative stress
    Masanori Horie
    Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan 1 1 Iseigaoka, Kitakyushu, Fukuoka 807 8555, Japan Health Research Institute HRI, National Institute of Advanced Industrial Science and Technology AIST, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan Electronic address
    Chemosphere 93:1182-8. 2013
    ..These results were similar to the cellular influences caused by C₆₀ which were reported by us previously. Although C₇₀ did not cause cell death, it caused the induction of intracellular oxidative stress...
  36. doi request reprint Cellular responses induced by cerium oxide nanoparticles: induction of intracellular calcium level and oxidative stress on culture cells
    Masanori Horie
    Health Research Institute, National Institute of Advanced Industrial Science and Technology AIST, 1 8 31, Midorigaoka, Ikeda, Osaka 563 8577, Japan
    J Biochem 150:461-71. 2011
    ..These results suggest that CeO(2) nanoparticles have a potential to induce intracellular oxidative stress and increase the intracellular Ca(2+) level, but these influences are small...
  37. doi request reprint Evaluation of cellular influences of platinum nanoparticles by stable medium dispersion
    Masanori Horie
    Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, Fukuoka 807 8555, Japan
    Metallomics 3:1244-52. 2011
    ..These results suggest that the physically and chemically inactive cellular influences of platinum nanoparticles are small...
  38. doi request reprint Dispersion characteristics of various metal oxide secondary nanoparticles in culture medium for in vitro toxicology assessment
    Haruhisa Kato
    Polymer Standards Section Japan, National Metrology Institute of Japan, National Institute of Advanced Industrial Science and Technology, Tsukuba Central 5, Higashi 1 1 1, Tsukuba, Ibaraki 305 8565, Japan
    Toxicol In Vitro 24:1009-18. 2010
    ..The estimation of particle dynamics in culture medium using this method would be significant to recognize the inherent toxicity of nanoparticles...
  39. ncbi request reprint Cholesterol is more susceptible to oxidation than linoleates in cultured cells under oxidative stress induced by selenium deficiency and free radicals
    Yoshiro Saito
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology AIST, Ikeda, Osaka 563 8577, Japan
    FEBS Lett 581:4349-54. 2007
    ..These results suggest that, in contrast to plasma oxidation where cholesterol is much more resistant to oxidation than linoleates, cellular cholesterol is more susceptible to oxidation than cellular linoleates...
  40. doi request reprint Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals
    Yoko Ogawa Akazawa
    Health Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Ikeda, Osaka, Japan
    Neurosci Lett 483:201-5. 2010
    ..These results suggest that the oxidative modification of DJ-1 in the brain and erythrocytes is involved in the pathogenesis of PD in animal models...
  41. ncbi request reprint Advantages and limitation of BODIPY as a probe for the evaluation of lipid peroxidation and its inhibition by antioxidants in plasma
    Nanako Itoh
    National Institute of Advanced Industrial Science and Technology AIST, Human Stress Signal Research Center, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Bioorg Med Chem Lett 17:2059-63. 2007
    ..These results show that BODIPY can be used as a convenient probe for radical scavenging, but that care should be taken for the evaluation of antioxidant capacity...
  42. ncbi request reprint Adaptive response induced by lipid peroxidation products in cell cultures
    Zhi Hua Chen
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, Midorigaoka, Ikeda, Osaka 563 8577, Japan
    FEBS Lett 580:479-83. 2006
    ..These findings suggest a general hormetic effect of such compounds in cell cultures and may lead to a reappraisal of the eventual role of reactive oxygen species and lipid peroxidation in organisms...
  43. ncbi request reprint Molecular mechanisms of 6-hydroxydopamine-induced cytotoxicity in PC12 cells: involvement of hydrogen peroxide-dependent and -independent action
    Yoshiro Saito
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, Kansai Center, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Free Radic Biol Med 42:675-85. 2007
    ..These findings may contribute to explain the importance of generated H2O2 and secondary products as a second messenger of 6-OHDA-induced cell death signal linked to Parkinson's disease...
  44. doi request reprint Cytoprotective effects of vitamin E homologues against glutamate-induced cell death in immature primary cortical neuron cultures: Tocopherols and tocotrienols exert similar effects by antioxidant function
    Yoshiro Saito
    Health Research Institute, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 563 8577, Japan
    Free Radic Biol Med 49:1542-9. 2010
    ..It is suggested that, considering the bioavailability, α-T should be more effective than α-T3 against glutamate toxicity in vivo...
  45. doi request reprint Action of 6-amino-3-pyridinols as novel antioxidants against free radicals and oxidative stress in solution, plasma, and cultured cells
    Yo Omata
    Health Technology Research Center, National Institute of Advanced Industrial Science and Technology, Osaka 563 8577, Japan
    Free Radic Biol Med 48:1358-65. 2010
    ..These results suggest that the novel 6-amino-3-pyridinols may be potent antioxidants against oxidative stress...
  46. ncbi request reprint Effect of oxygen concentration on free radical-induced cytotoxicity
    Zhi Hua Chen
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 563 8577, Japan
    Biosci Biotechnol Biochem 72:1491-7. 2008
    ..Taken together, the results indicate that free radicals induced hypoxic conditions, which accelerated mitochondria-dependent cell apoptosis...
  47. ncbi request reprint Protective effects of 15-deoxy-Delta12,14-prostaglandin J2 against glutamate-induced cell death in primary cortical neuron cultures: induction of adaptive response and enhancement of cell tolerance primarily through up-regulation of cellular glutathione
    Yoshiro Saito
    Human Stress Signal Research Center HSSRC, National Institute of Advanced Industrial Science and Technology AIST, Ikeda, Osaka, Japan
    J Neurochem 102:1625-34. 2007
    ..These findings indicate that at low levels, 15d-PGJ(2) acts as a potent survival mediator against glutamate-induced insults via the induction of an adaptive response primarily through the up-regulation of the intracellular GSH synthesis...
  48. ncbi request reprint Cytotoxic effects of various stressors on PC12 cells: involvement of oxidative stress and effect of antioxidants
    Rosaria Piga
    Human Stress Signal Research Center HSSRC, National Institute of Advanced Industrial Science and Technology AIST, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Neurotoxicology 28:67-75. 2007
    ..These results suggest that the involvement of ROS and the protective effect of antioxidants depend on the type of stressors...
  49. ncbi request reprint S-allyl cysteine prevents CCl(4)-induced acute liver injury in rats
    Shintaro Kodai
    Department of Hepato Biliary Pancreatic Surgery, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Free Radic Res 41:489-97. 2007
    ..These results suggest that SAC decreased CCl(4)-induced liver injury by attenuation of oxidative stress, and may be a better therapeutic tool for chronic liver disease...
  50. doi request reprint Assessment of radical scavenging capacity and lipid peroxidation inhibiting capacity of antioxidant
    Etsuo Niki
    National Institute of Advanced Industrial Science and Technology, Human Stress Signal Research Center, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    J Agric Food Chem 56:8255-60. 2008
    ..Thus, the capacity of antioxidants for inhibition of lipid peroxidation should be assessed from the effect on the extent of oxidation, not from the effect on probe decay...
  51. doi request reprint Capacity of peroxyl radical scavenging and inhibition of lipid peroxidation by β-carotene, lycopene, and commercial tomato juice
    Mizuki Takashima
    Health Research Institute, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka, Japan
    Food Funct 3:1153-60. 2012
    ..The peroxyl radical scavenging capacity of β-carotene and lycopene exhibited was about one-tenth of that observed for α-tocopherol, and the efficacy of lipid peroxidation inhibition was much smaller...
  52. doi request reprint Association of zinc ion release and oxidative stress induced by intratracheal instillation of ZnO nanoparticles to rat lung
    Hiroko Fukui
    Health Research Institute HRI, National Institute of Advanced Industrial Science and Technology AIST, Ikeda, Osaka, Japan
    Chem Biol Interact 198:29-37. 2012
    ..Intracellular ROS level had a high correlation with intracellular Zn(2+) level. ZnO nanoparticles will stay in the lung and continually release zinc ion, and thus stronger oxidative stress is induced...
  53. ncbi request reprint Inhibition of plasma lipid peroxidation by anti-atherogenic antioxidant BO-653, 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran
    Nanako Itoh
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology AIST, 1 8 31 Midorigaoka Ikeda, Osaka 563 8577, Japan
    Biochem Pharmacol 68:813-8. 2004
    ....
  54. doi request reprint In vitro evaluation of cellular responses induced by stable fullerene C60 medium dispersion
    Masanori Horie
    Health Research Institute HRI, National Institute of Advanced Industrial Science and Technology AIST, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    J Biochem 148:289-98. 2010
    ..The results obtained from this study indicate that C60 has oxidative stress induction potential. Further examinations including in vivo studies are necessary for a more accurate evaluation of biological influences by C60...
  55. doi request reprint Protein adsorption of ultrafine metal oxide and its influence on cytotoxicity toward cultured cells
    Masanori Horie
    Health Technology Research Center HTRC, National Institute of Advanced Industrial Science and Technology AIST, 1 8 31, Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Chem Res Toxicol 22:543-53. 2009
    ..In conclusion, the adsorption ability of metal oxide nanoparticles is an important factor for the estimation of cytotoxicity in vitro for low-toxicity materials...
  56. doi request reprint α-Tocopheryl phosphate: uptake, hydrolysis, and antioxidant action in cultured cells and mouse
    Keiko Nishio
    Health Research Institute, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 563 8577, Japan
    Free Radic Biol Med 50:1794-800. 2011
    ..These results suggest that α-TP is readily hydrolyzed in vivo to α-T, which acts as an antioxidant, and that α-TP may be used as a water-soluble α-T precursor in intravenous fluids, in eye drops, or as a dietary supplement...
  57. doi request reprint Reactivity toward oxygen radicals and antioxidant action of thiol compounds
    Mizuki Takashima
    Health Research Institute, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka, Japan
    Biofactors 38:240-8. 2012
    ..The reactivity toward free radicals and antioxidant capacity of these thiol compounds were less than that of ascorbic acid, but higher than that of uric acid...
  58. doi request reprint Assessment of antioxidant capacity for scavenging free radicals in vitro: a rational basis and practical application
    Mizuki Takashima
    Health Research Institute, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 563 8577, Japan
    Free Radic Biol Med 52:1242-52. 2012
    ..This method was applied to the assessment of radical-scavenging capacity of human plasma, wine, and green tea powder...
  59. doi request reprint Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults
    Keiko Nishio
    Health Technology Research Center, National Institute of Advanced Industrial Science and Technology AIST, Ikeda, Osaka 563 8577, Japan
    Bioorg Med Chem 16:10332-7. 2008
    ..These results suggest the beneficial effects of the furan compounds against disorders related to glutamate and lipopolysaccharide...
  60. ncbi request reprint Cytotoxic effect of formaldehyde with free radicals via increment of cellular reactive oxygen species
    Yoshiro Saito
    Human Stress Signal Research Center HSSRC, National Institute of Advanced Industrial Science and Technology AIST, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Toxicology 210:235-45. 2005
    ....
  61. doi request reprint Proteomics- and transcriptomics-based screening of differentially expressed proteins and genes in brain of Wig rat: a model for attention deficit hyperactivity disorder (ADHD) research
    Misato Hirano
    Human Stress Signal Research Center HSS, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba West, 16 1 Onogawa, Tsukuba 305 8569, Japan
    J Proteome Res 7:2471-89. 2008
    ....
  62. doi request reprint α-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome
    Mototada Shichiri
    Health Research Institute, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 563 8577, Japan
    Free Radic Biol Med 50:1801-11. 2011
    ..These results imply that α-tocopherol supplementation from an early stage may be an effective treatment for the cognitive deficits associated with Down syndrome...
  63. ncbi request reprint Turning point in apoptosis/necrosis induced by hydrogen peroxide
    Yoshiro Saito
    National Institute of Advanced Industrial Science and Technology AIST, Human Stress Signal Research Center HSSRC, Ikeda, Osaka 563 8577, Japan
    Free Radic Res 40:619-30. 2006
    ..These results suggest that ATP-dependent apoptosome formation determines whether H2O2-induced cell death is due to apoptosis or necrosis...
  64. doi request reprint Ultrafine NiO particles induce cytotoxicity in vitro by cellular uptake and subsequent Ni(II) release
    Masanori Horie
    Health Technology Research Center, National Institute of Advanced Industrial Science and Technology, 1 8 31, Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Chem Res Toxicol 22:1415-26. 2009
    ..Taken together, the present results suggest that the intracellular Ni(2+) release could be an important factor that determines the cytotoxicity of NiO. Ultrafine NiO is more cytotoxic than fine NiO in vitro...
  65. doi request reprint Clearance kinetics of fullerene C₆₀ nanoparticles from rat lungs after intratracheal C₆₀ instillation and inhalation C₆₀ exposure
    Naohide Shinohara
    Research Institute of Science for Safety and Sustainability RISS, National Institute of Advanced Industrial Science and Technology, Onogawa 16 1, Tsukuba, Ibaraki 305 8569, Japan
    Toxicol Sci 118:564-73. 2010
    ..This finding is consistent with the transmission electron microscopy finding that many particles were present in alveolar macrophages...
  66. ncbi request reprint Regulation of GCL activity and cellular glutathione through inhibition of ERK phosphorylation
    Zhi Hua Chen
    Human Stress Signal Research Center HSSRC, National Institute of Advanced Industrial Science and Technology AIST, Osaka, Japan
    Biofactors 33:1-11. 2008
    ..This study would also help us to understand the comprehensive role of the Raf/MEK/ERK pathway in overall physio/pathological conditions...
  67. ncbi request reprint Simultaneous determination of nitrate and nitrite in biological fluids by capillary electrophoresis and preliminary study on their determination by microchip capillary electrophoresis
    Takashi Miyado
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka, Japan
    J Chromatogr A 1051:185-91. 2004
    ..The method was applied to human serum and saliva. We obtained peaks due to nitrite and nitrate in 10-fold diluted saliva...
  68. ncbi request reprint Induction of adaptive response and enhancement of PC12 cell tolerance by 7-hydroxycholesterol and 15-deoxy-delta(12,14)-prostaglandin J2 through up-regulation of cellular glutathione via different mechanisms
    Zhi Hua Chen
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, 1 8 31, Midorigaoka, Ikeda, Osaka, 563 8577, Japan
    J Biol Chem 281:14440-5. 2006
    ..These results demonstrate that the adaptive response induced by both 7-OHCh and 15d-PGJ2 is mediated similarly through the up-regulation of GSH but via different mechanisms...
  69. ncbi request reprint Biomarkers for oxidative stress: measurement, validation, and application
    Etsuo Niki
    National Institute of Advanced Industrial Science and Technology, Human Stress Signal Research Center, Osaka, Japan
    J Med Invest 52:228-30. 2005
    ..Total hydroxyoctadecadienoic acid (HODE) and 7-hydroxycholesterol measured after reduction and saponification of biological fluids may be used as reliable biomarker...
  70. ncbi request reprint Antioxidant action of a lipophilic nitroxyl radical, cyclohexane-1-spiro-2'-(4'-oxyimidazolidine-1'-oxyl) -5'-spiro-1"-cyclohexane, against lipid peroxidation under hypoxic conditions
    Shuichi Shimakawa
    Human Stress Signal Research Center HSSRC, National Institute of Advanced Industrial Science and Technology AIST, Japan, Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Lipids 38:225-31. 2003
    ..The present study suggests that nitroxyl radical I and its hydroxylamine may act as potent antioxidants, especially in combination with ascorbic acid under hypoxic conditions...
  71. ncbi request reprint Susceptibility of plasma lipids to peroxidation
    Yasukazu Yoshida
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Biochem Biophys Res Commun 305:747-53. 2003
    ..It was confirmed that free radical-mediated oxidation gave both cis,trans and trans,trans, racemic, random hydroperoxides, while that by lipoxygenase gave only regio- and stereo-specific cis,trans-hydroperoxide...
  72. ncbi request reprint Proteomic characterization of oxidative dysfunction in human umbilical vein endothelial cells (HUVEC) induced by exposure to oxidized LDL
    Tomoya Kinumi
    Human Stress Signal Research Center HSSRC, National Institute of Advanced Industrial Science and Technology AIST, Ikeda, Osaka 563 8577, Japan
    Free Radic Res 39:1335-44. 2005
    ....
  73. doi request reprint Characterization of cellular uptake and distribution of coenzyme Q10 and vitamin E in PC12 cells
    Yoshiro Saito
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 563 8577, Japan
    J Nutr Biochem 20:350-7. 2009
    ..These results indicate that the cellular distribution of CoQ is completely different from that of alphaT; moreover, a certain system which accumulates CoQ preferentially in mitochondria may be suggested...
  74. ncbi request reprint Characterization of monochloramine toxicity on PC12 cells and protective effect of tocopherol via antioxidative function
    Rosaria Piga
    Human Stress Signal Research Center HSSRC, National Institute of Advanced Industrial Science and Technology AIST, Ikeda, Osaka 563 8577, Japan
    Arch Biochem Biophys 436:101-9. 2005
    ..These results suggest that free radical mediated process is involved in NH(2)Cl-induced PC12 cell death and that tocopherols inhibit this cell death via antioxidative function...
  75. doi request reprint Severe Vitamin E deficiency exacerbates acute hyperoxic lung injury associated with increased oxidative stress and inflammation
    Shigeo Yamaoka
    Department of Pediatrics, Perinatal Center, Osaka Medical College, Takatsuki, Osaka, Japan
    Free Radic Res 42:602-12. 2008
    ..It was concluded that severe vitamin E deficiency exacerbates acute hyperoxic lung injury associated with increased oxidative stress or inflammation...
  76. ncbi request reprint Characterization of cellular uptake and distribution of vitamin E
    Yoshiro Saito
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577 Japan
    Ann N Y Acad Sci 1031:368-75. 2004
    ..These results suggest that the apparent higher cytoprotective effect of alpha-Toc-3 than alpha-Toc is primarily ascribed to its higher cellular uptake...
  77. ncbi request reprint 4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2
    Zhi Hua Chen
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, 1 8 31, Midorigaoka, Ikeda, Osaka 563 8577
    J Biol Chem 280:41921-7. 2005
    ....
  78. ncbi request reprint gamma-Tocopherol attenuates MPTP-induced dopamine loss more efficiently than alpha-tocopherol in mouse brain
    Nanako Itoh
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, AIST, 1 8 31 Midorigaoka Ikeda, Osaka 563 8577, Japan
    Neurosci Lett 403:136-40. 2006
    ..Collectively, this is the first report showing that the protective effect of gammaT is stronger than that of alphaT against the MPTP-induced damage of dopaminergic neurons in the mouse...
  79. doi request reprint Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients
    Yoshiro Saito
    Health Technology Research Center, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka, Japan
    Neurosci Lett 465:1-5. 2009
    ..These results suggest the oxidative modification of DJ-1 in PD patients and the potential application of the antibody for diagnosis of PD at early-stage...
  80. ncbi request reprint Lipid peroxidation: mechanisms, inhibition, and biological effects
    Etsuo Niki
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, Osaka 563 8577, Japan
    Biochem Biophys Res Commun 338:668-76. 2005
    ..Furthermore, the biological role of lipid peroxidation products has recently received a great deal of attention, but its physiological significance must be demonstrated in future studies...
  81. ncbi request reprint Cell death caused by selenium deficiency and protective effect of antioxidants
    Yoshiro Saito
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    J Biol Chem 278:39428-34. 2003
    ....
  82. doi request reprint Antioxidant capacity of BO-653, 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran, and uric acid as evaluated by ORAC method and inhibition of lipid peroxidation
    Etsuo Niki
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology AIST, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Bioorg Med Chem Lett 18:2464-6. 2008
    ..The results suggest that ORAC method is suitable for the assessment of free radical scavenging capacity, but not for the assessment of antioxidant capacity against lipid peroxidation in plasma...
  83. doi request reprint Reliable size determination of nanoparticles using dynamic light scattering method for in vitro toxicology assessment
    Haruhisa Kato
    Polymer Standards Section Japan, National Metrology Institute of Japan, National Institute of Advanced Industrial Science and Technology, Tsukuba Central 5, Tsukuba, Ibaraki 305 8565, Japan
    Toxicol In Vitro 23:927-34. 2009
    ..Furthermore, TiO(2) secondary nanoparticle suspensions are well dispersed with slow gravity settling, no agglomeration, with the diffusion process as the primary transport mode of particles to cells...
  84. doi request reprint Gene expression profiles in rat lung after inhalation exposure to C60 fullerene particles
    Katsuhide Fujita
    Health Technology Research Center, National Institute of Advanced Industrial Science and Technology AIST, Onogawa 16 1, Tsukuba, Ibaraki 305 8569, Japan
    Toxicology 258:47-55. 2009
    ..We suggest that C(60) fullerene might not have a severe pulmonary toxicity under the inhalation exposure condition...
  85. ncbi request reprint Distribution of tocopherols and tocotrienols to rat ocular tissues after topical ophthalmic administration
    Masaki Tanito
    Department of Ophthalmology, Shimane University School of Medicine, Shimane, 693 8501, Japan
    Lipids 39:469-74. 2004
    ..Topical administration of tocotrienols is thus an effective way to increase ocular tissue vitamin E concentration...
  86. ncbi request reprint Adaptation to hydrogen peroxide enhances PC12 cell tolerance against oxidative damage
    Zhi Hua Chen
    Human Stress Signal Research Center HSSRC, National Institute of Advanced Industrial Science and Technology AIST, 1 8 31, Ikeda, Osaka 563 8577, Japan
    Neurosci Lett 383:256-9. 2005
    ....
  87. ncbi request reprint Effects of a novel gaseous antioxidative system containing a rosemary extract on the oxidation induced by nitrogen dioxide and ultraviolet radiation
    Yoshiro Saito
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka, Japan
    Biosci Biotechnol Biochem 68:781-6. 2004
    ..These data suggest that the volatile constituents of a rosemary extract had antioxidative properties and that gaseous exposure antioxidant is a promising method for promoting health...
  88. ncbi request reprint Chemical reactivities and physical effects in comparison between tocopherols and tocotrienols: physiological significance and prospects as antioxidants
    Yasukazu Yoshida
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    J Biosci Bioeng 104:439-45. 2007
    ..Moreover, the physiological significance and future prospects for using vitamin E, especially tocotrienols, for the prevention and treatment of disease are discussed...
  89. doi request reprint Comprehensive royal jelly (RJ) proteomics using one- and two-dimensional proteomics platforms reveals novel RJ proteins and potential phospho/glycoproteins
    Takako Furusawa
    Food Function Laboratory, School of Agriculture, Ibaraki University, Ami, Japan
    J Proteome Res 7:3194-229. 2008
    ..The 2-DGE data were integrated to develop a 2-D gel reference map, and all data are accessible through RJ proteomics portal (http://foodfunc.agr.ibaraki.ac.jp/RJP.html)...
  90. doi request reprint Simple assessment of radical scavenging capacity of beverages
    Yo Omata
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    J Agric Food Chem 56:3386-90. 2008
    ....
  91. ncbi request reprint Protection against oxidative stress-induced hepatic injury by intracellular type II platelet-activating factor acetylhydrolase by metabolism of oxidized phospholipids in vivo
    Nozomu Kono
    Graduate School of Pharmaceutical Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 283:1628-36. 2008
    ..These results indicate that PAF-AH (II) is involved in the metabolism of esterified 8-isoprostaglandin F(2alpha) and protects tissue from oxidative stress-induced injury...
  92. ncbi request reprint Oxidative status of human low density lipoprotein isolated by anion-exchange high-performance liquid chromatography--assessment by total hydroxyoctadecadienoic acid, 7-hydroxycholesterol, and 8-iso-prostaglandin F(2alpha)
    Soichi Kitano
    Technology Development Department, SRL Inc, 153 Komiya, Hachioji, Tokyo 192 0031, Japan
    Anal Chim Acta 585:86-93. 2007
    ....
  93. ncbi request reprint Acceleration of age-related changes in the retina in alpha-tocopherol transfer protein null mice fed a Vitamin E-deficient diet
    Masaki Tanito
    Department of Ophthalmology, Shimane University School of Medicine, Shimane, Japan
    Invest Ophthalmol Vis Sci 48:396-404. 2007
    ..To assess the role of vitamin E (VE) in age-related changes in the retinal tissues by using a mouse model of severe VE deficiency...
  94. ncbi request reprint Detection of lipid peroxidation in light-exposed mouse retina assessed by oxidative stress markers, total hydroxyoctadecadienoic acid and 8-iso-prostaglandin F2alpha
    Masaki Tanito
    Department of Ophthalmology, Shimane University School of Medicine, 89 1 Enya, Izumo, Shimane 693 8501, Japan
    Neurosci Lett 398:63-8. 2006
    ..These results demonstrate that tHODE and 8-iso-PGF2alpha assessed by the present method are appropriate biomarkers responding to retinal photooxidative stress in vivo...
  95. ncbi request reprint Action of 1-(11-selenadodecyl)-glycerol and 1-(11-selenadodecyl)-3-trolox-glycerol against lipid peroxidation
    Violeta Raneva
    First Department of Biochemistry, Teikyo University School of Medicine, Tokyo, Japan
    Lipids 37:633-40. 2002
    ..The two selenium-containing compounds showed inhibitory effects on lipid peroxidation that depended on their structure, the medium where they acted, and the oxidant used...
  96. doi request reprint Systematic investigation of the hemolymph proteome of Manduca sexta at the fifth instar larvae stage using one- and two-dimensional proteomics platforms
    Takako Furusawa
    Food Function Laboratory, School of Agriculture, Ibaraki University, Ami 300 0393, Japan
    J Proteome Res 7:938-59. 2008
    ..sexta. These proteins correlate well with the fifth instar stage, the transition from larvae to pupae...
  97. ncbi request reprint Cytoprotective effects of rebamipide and carteolol hydrochloride against ultraviolet B-induced corneal damage in mice
    Masaki Tanito
    Department of Ophthalmology, Shimane Medical University, Izumo, Shimane, Japan
    Invest Ophthalmol Vis Sci 44:2980-5. 2003
    ..To analyze whether rebamipide (REB) and carteolol hydrochloride (CH) protect against UVB-induced corneal damage in mice...
  98. ncbi request reprint Preparation of biotinylated cypridina luciferase and its use in bioluminescent enzyme immunoassay
    Chun Wu
    Research Institute for Cell Engineering, National Institute of Advanced Industrial Science and Technology AIST, Osaka 563 8577, Japan
    Anal Chem 79:1634-8. 2007
    ..The linearity of this immunoassay extended from 7.8 to 500 pg/mL interferon-alpha. Our results show that Cypridina luciferase is a very sensitive and versatile bioluminescent reporter...