Jun Yokota

Summary

Affiliation: National Cancer Center
Country: Japan

Publications

  1. ncbi request reprint Molecular footprints of human lung cancer progression
    Jun Yokota
    Biology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 95:197-204. 2004
  2. ncbi request reprint Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers
    Masaki Fujieda
    Laboratory of Drug Metabolism, Division of Pharmacobio dynamics, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Carcinogenesis 25:2451-8. 2004
  3. ncbi request reprint Tumor progression and metastasis
    J Yokota
    Biology Division, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 21:497-503. 2000
  4. ncbi request reprint Genetic alterations responsible for metastatic phenotypes of lung cancer cells
    Jun Yokota
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Clin Exp Metastasis 20:189-93. 2003
  5. ncbi request reprint Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk
    Tokuki Sakiyama
    Center for Medical Genomics, National Cancer Center Research Institute, Tokyo, Japan
    Int J Cancer 114:730-7. 2005
  6. doi request reprint Whole genome comparison of allelic imbalance between noninvasive and invasive small-sized lung adenocarcinomas
    Hirofumi Nakanishi
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 69:1615-23. 2009
  7. doi request reprint Association of KRAS polymorphisms with risk for lung adenocarcinoma accompanied by atypical adenomatous hyperplasias
    Takashi Kohno
    Biology Division, National Cancer Center Research Institute, Tokyo 1040045, Japan
    Carcinogenesis 29:957-63. 2008
  8. ncbi request reprint Identification of D19S246 as a novel lung adenocarcinoma susceptibility locus by genome survey with 10-cM resolution microsatellite markers
    Noriko Yanagitani
    Biology Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Cancer Epidemiol Biomarkers Prev 12:366-71. 2003
  9. ncbi request reprint Biological properties and gene expression associated with metastatic potential of human osteosarcoma
    Tetsuhiro Nakano
    Division of Biology, National Cancer Center Research Institute, Tokyo, Japan
    Clin Exp Metastasis 20:665-74. 2003
  10. ncbi request reprint Pathogenetic and biologic significance of TP14ARF alterations in nonsmall cell lung carcinoma
    Myung Jae Park
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Genet Cytogenet 141:5-13. 2003

Detail Information

Publications91

  1. ncbi request reprint Molecular footprints of human lung cancer progression
    Jun Yokota
    Biology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 95:197-204. 2004
    ..Thus, identification of environmental as well as genetic factors inducing or suppressing the occurrence of such alterations would be a clue to find novel ways of lung cancer prevention...
  2. ncbi request reprint Evaluation of CYP2A6 genetic polymorphisms as determinants of smoking behavior and tobacco-related lung cancer risk in male Japanese smokers
    Masaki Fujieda
    Laboratory of Drug Metabolism, Division of Pharmacobio dynamics, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Carcinogenesis 25:2451-8. 2004
    ..10) were lower than that of adenocarcinoma (OR of 0.39) in group 4. These results suggest that the CYP2A6 is one of the principal determinants affecting not only smoking behavior but also susceptibility to tobacco-related lung cancer...
  3. ncbi request reprint Tumor progression and metastasis
    J Yokota
    Biology Division, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 21:497-503. 2000
    ..Here, I review the progress on molecular studies of tumor progression and metastasis of the past 20 years and discuss the future direction in this field of science...
  4. ncbi request reprint Genetic alterations responsible for metastatic phenotypes of lung cancer cells
    Jun Yokota
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Clin Exp Metastasis 20:189-93. 2003
    ..Further functional and biological studies of the MYO18B gene will help us understand the molecular pathway of human lung cancer progression...
  5. ncbi request reprint Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk
    Tokuki Sakiyama
    Center for Medical Genomics, National Cancer Center Research Institute, Tokyo, Japan
    Int J Cancer 114:730-7. 2005
    ..The present results suggest that these 4 SNPs function as genetic factors underlying lung cancer susceptibility by modulating activities to maintain the genome integrity of each individual...
  6. doi request reprint Whole genome comparison of allelic imbalance between noninvasive and invasive small-sized lung adenocarcinomas
    Hirofumi Nakanishi
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 69:1615-23. 2009
    ..04) and, thus, would be involved in invasion and/or metastasis of adenocarcinoma cells and useful for the prediction of prognosis of patients with small-sized lung adenocarcinoma...
  7. doi request reprint Association of KRAS polymorphisms with risk for lung adenocarcinoma accompanied by atypical adenomatous hyperplasias
    Takashi Kohno
    Biology Division, National Cancer Center Research Institute, Tokyo 1040045, Japan
    Carcinogenesis 29:957-63. 2008
    ..Thus, KRAS polymorphisms were indicated to be involved in risk for the development of AAHs that progress to ADC by causing differential KRAS oncogene expression in the lungs...
  8. ncbi request reprint Identification of D19S246 as a novel lung adenocarcinoma susceptibility locus by genome survey with 10-cM resolution microsatellite markers
    Noriko Yanagitani
    Biology Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Cancer Epidemiol Biomarkers Prev 12:366-71. 2003
    ..These results suggest that the chromosome 19q13.3 region encompassing D19S246 contains a gene(s) of which the genetic polymorphisms are associated with lung adenocarcinoma risk and are in linkage disequilibrium with the D19S246 locus...
  9. ncbi request reprint Biological properties and gene expression associated with metastatic potential of human osteosarcoma
    Tetsuhiro Nakano
    Division of Biology, National Cancer Center Research Institute, Tokyo, Japan
    Clin Exp Metastasis 20:665-74. 2003
    ..These results suggest that the differences in motility/invasiveness and adhesive abilities are key determinants of lung metastasis in osteosarcoma...
  10. ncbi request reprint Pathogenetic and biologic significance of TP14ARF alterations in nonsmall cell lung carcinoma
    Myung Jae Park
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Genet Cytogenet 141:5-13. 2003
    ..Thus, the pathogenetic and biologic significance of TP14ARF inactivation is different between NSCLC cells with wild-type TP53 and those with mutated TP53...
  11. pmc MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer
    Michiho Nishioka
    National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Proc Natl Acad Sci U S A 99:12269-74. 2002
    ..These results indicate that the MYO18B gene is a strong candidate for a novel tumor suppressor gene whose inactivation is involved in lung cancer progression...
  12. ncbi request reprint Effect of exogenous MSH6 and POLD1 expression on the mutation rate of the HPRT locus in a human colon cancer cell line with mutator phenotype, DLD-1
    Tomonori Yabuta
    Biology Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Oncol 24:697-702. 2004
    ..Thus, it was indicated that mutations in the MSH6 gene, and not in the POLD1 gene, are primarily responsible for the elevated mutation rates in DLD-1 cells...
  13. ncbi request reprint Clonality and heterogeneity of pulmonary blastoma from the viewpoint of genetic alterations: a case report
    Kenji Takahashi
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Lung Cancer 57:103-8. 2007
    ..These results indicate that this biphasic tumor is of monoclonal origin and the phenotypic heterogeneity of the tumor is due to the differences in the accumulated genetic alterations in each component of the tumor...
  14. ncbi request reprint Clonal and parallel evolution of primary lung cancers and their metastases revealed by molecular dissection of cancer cells
    Kenji Takahashi
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Clin Cancer Res 13:111-20. 2007
    ..The purpose of this study is to investigate the authenticity of these models by comparison of accumulated genetic alterations between primary and corresponding metastatic lung cancers...
  15. ncbi request reprint Association of the OGG1-Ser326Cys polymorphism with lung adenocarcinoma risk
    Takashi Kohno
    Biology Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045
    Cancer Sci 97:724-8. 2006
    ..43 (95% CI = 1.11-1.84, P = 0.0045). These results indicate that OGG1-326Cys functions as a risk allele for lung ADC development...
  16. doi request reprint Association of p16 homozygous deletions with clinicopathologic characteristics and EGFR/KRAS/p53 mutations in lung adenocarcinoma
    Reika Iwakawa
    Biology Division, National Cancer Center Hospital, Tokyo, Japan
    Clin Cancer Res 14:3746-53. 2008
    ..The purpose of this study was to elucidate the prevalence and the timing for the occurrence of p16 HDs in lung adenocarcinoma progression in vivo...
  17. doi request reprint Contribution of the TP53, OGG1, CHRNA3, and HLA-DQA1 genes to the risk for lung squamous cell carcinoma
    Takashi Kohno
    Biology Division, National Cancer Center Research Institute Division of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan
    J Thorac Oncol 6:813-7. 2011
    ..Therefore, significance of these functional polymorphisms was evaluated in a population, in which polymorphisms in the GWAS genes showed associations with lung SQC risk...
  18. ncbi request reprint Identification of genes whose expression is upregulated in lung adenocarcinoma cells in comparison with type II alveolar cells and bronchiolar epithelial cells in vivo
    Keiko Kobayashi
    Biology Division, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Oncogene 23:3089-96. 2004
    ..These results strongly indicate that the MMP15 and MX2 genes could be novel markers for molecular diagnosis and therapy of lung AdC...
  19. ncbi request reprint Mutations and deletions of the CBP gene in human lung cancer
    Masahiro Kishimoto
    Biology Division, National Cancer Center Research Institute, 1 1 Tsukiji 5 Chome Chuo Ku, Tokyo 104 0045, Japan
    Clin Cancer Res 11:512-9. 2005
    ....
  20. ncbi request reprint Homozygous deletion and reduced expression of the DOCK8 gene in human lung cancer
    Kenji Takahashi
    Division of Biology, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Oncol 28:321-8. 2006
    ..Thus, the present results suggest that genetic and epigenetic inactivation of DOCK8 is involved in the development and/or progression of lung and other cancers by disturbing such regulations...
  21. pmc A catalog of genes homozygously deleted in human lung cancer and the candidacy of PTPRD as a tumor suppressor gene
    Takashi Kohno
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Genes Chromosomes Cancer 49:342-52. 2010
    ..Genetic/epigenetic as well as functional studies of these 176 genes will increase our understanding of molecular mechanisms behind lung carcinogenesis...
  22. pmc CUB domain-containing protein 1 is a novel regulator of anoikis resistance in lung adenocarcinoma
    Takamasa Uekita
    Growth Factor Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Mol Cell Biol 27:7649-60. 2007
    ..Loss of CDCP1 also inhibited the metastatic potential of the A549 cells in vivo. Our findings indicate that CDCP1 is a novel target for treating cancer-specific disorders, such as metastasis, by regulating anoikis in lung adenocarcinoma...
  23. ncbi request reprint Differential ability of polymorphic OGG1 proteins to suppress mutagenesis induced by 8-hydroxyguanine in human cell in vivo
    Arito Yamane
    Biology Division, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 25:1689-94. 2004
    ....
  24. ncbi request reprint Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer
    Nozomu Yanaihara
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Int J Cancer 112:150-4. 2004
    ..The present results suggest that MYO18B alterations, including both epigenetic and genetic alterations, play an important role in ovarian carcinogenesis...
  25. doi request reprint Individuals susceptible to lung adenocarcinoma defined by combined HLA-DQA1 and TERT genotypes
    Takashi Kohno
    Biology Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Carcinogenesis 31:834-41. 2010
    ..76 (95% CI = 2.53-9.47, P = 4.2 x 10(-7)). The present results indicated that individuals susceptible to lung ADC can be defined by combined genotypes of HLA-DQA1 and TERT...
  26. doi request reprint A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population
    Kouya Shiraishi
    Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan
    Nat Genet 44:900-3. 2012
    ..4 × 10(-11), OR = 1.20) and 6p21.3 (rs3817963, P(combined) = 2.7 × 10(-10), OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma...
  27. doi request reprint MYC amplification as a prognostic marker of early-stage lung adenocarcinoma identified by whole genome copy number analysis
    Reika Iwakawa
    Biology Division, National Cancer Center Research Institute Cancer Genomics Project, The University of Tokyo, Tokyo, Japan
    Clin Cancer Res 17:1481-9. 2011
    ..The purpose of this study was to identify genetic alterations that define prognosis of patients with early-stage lung ADC...
  28. ncbi request reprint Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma
    Yoshio Tomizawa
    Biology Division, Pathology Division, National Cancer Center Hospital, Tokyo 104 0045, Japan
    Clin Cancer Res 8:2362-8. 2002
    ..In this study, we investigated the pathogenetic and clinicopathological significances of RASSF1A methylation in the development and/or progression of lung adenocarcinoma...
  29. ncbi request reprint Homozygous deletion scanning of the lung cancer genome at a 100-kb resolution
    Kazuhiro Nagayama
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Genes Chromosomes Cancer 46:1000-10. 2007
    ..The present study provides a list of protein- and miRNA-encoding genes whose inactivation is possibly involved in lung carcinogenesis...
  30. ncbi request reprint Contribution of the NQO1 and GSTT1 polymorphisms to lung adenocarcinoma susceptibility
    Noriaki Sunaga
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 11:730-8. 2002
    ..Therefore, carcinogens in tobacco smoke, which are activated by NQO1 and detoxified by GSTT1, could have a role in lung adenocarcinoma development...
  31. doi request reprint Involvement of LKB1 in epithelial-mesenchymal transition (EMT) of human lung cancer cells
    Badal C Roy
    Biology Division, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Lung Cancer 70:136-45. 2010
    ..These results strongly indicate that LKB1 inactivation triggers EMT in lung cancer cells through the induction of ZEB1...
  32. ncbi request reprint Activation of the AKT and STAT3 pathways and prolonged survival by a mutant EGFR in human lung cancer cells
    Hakan Akca
    Biology Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Lung Cancer 54:25-33. 2006
    ..This specific property due to EGFR mutation could be an important step of multistage lung cancer progression...
  33. ncbi request reprint Association of polymorphisms in the MTH1 gene with small cell lung carcinoma risk
    Takashi Kohno
    Center for Medical Genomics, Tokyo, Japan
    Carcinogenesis 27:2448-54. 2006
    ..0 (95% CI: 1.2-3.2, P=0.002). The present results indicate that inter-individual differences in MTH1 activities due to SNPs are involved in susceptibility to SCLC...
  34. ncbi request reprint Genetic and epigenetic alterations of the candidate tumor-suppressor gene MYO18B, on chromosome arm 22q, in colorectal cancer
    Tetsuhiro Nakano
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Genes Chromosomes Cancer 43:162-71. 2005
    ..These results suggest that genetic and epigenetic inactivation of the MYO18B gene play an important role in colorectal carcinogenesis...
  35. ncbi request reprint Frequent EGFR mutations in brain metastases of lung adenocarcinoma
    Shingo Matsumoto
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Int J Cancer 119:1491-4. 2006
    ..These results indicate that EGFR mutations are present frequently in brain metastases and occur preceding brain metastasis. These findings will be highly informative for treatment of metastatic lung adenocarcinoma to the brain...
  36. doi request reprint Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas
    Hirokazu Okayama
    Divisions of Multistep Carcinogenesis, Genome Biology, Cancer Genomics and Genetics, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 72:100-11. 2012
    ....
  37. ncbi request reprint Identification of chromosome arm 9p as the most frequent target of homozygous deletions in lung cancer
    Masamitsu Sato
    Biology Division, National Cancer Center Research Institute, 1 1 Tsukiji, 5 Chome, Chuo Ku, Tokyo, Japan
    Genes Chromosomes Cancer 44:405-14. 2005
    ..Thus, it was indicated that 9p is the most frequent target of homozygous deletions in lung cancer, suggesting that the arm contains multiple lung tumor suppressor genes and/or genomic features fragile during lung carcinogenesis...
  38. doi request reprint Contribution of nicotine acetylcholine receptor polymorphisms to lung cancer risk in a smoking-independent manner in the Japanese
    Kouya Shiraishi
    Biology Division, National Cancer Center Research Institute, National Cancer Center Hospital, Tokyo, Japan
    Carcinogenesis 30:65-70. 2009
    ..These results strongly indicate that CHRNA SNPs confer lung cancer susceptibility in a small subset of Japanese in a smoking-independent manner...
  39. ncbi request reprint Molecular processes of chromosome 9p21 deletions in human cancers
    Shigeru Sasaki
    Biology Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Oncogene 22:3792-8. 2003
    ..It was also indicated that two broken DNA ends are rejoined by nonhomologous end-joining repair, preferentially utilizing microhomologies of DNA ends, in the occurrence of 9p21 deletions...
  40. doi request reprint Association of DNA repair gene polymorphisms with response to platinum-based doublet chemotherapy in patients with non-small-cell lung cancer
    Kouya Shiraishi
    National Cancer Center Research Institute, Tokyo, Japan
    J Clin Oncol 28:4945-52. 2010
    ..To identify polymorphisms in DNA repair genes that affect responses to platinum-based doublet chemotherapy in patients with non-small-cell lung cancer (NSCLC)...
  41. ncbi request reprint Suppressive activities of OGG1 and MYH proteins against G:C to T:A mutations caused by 8-hydroxyguanine but not by benzo[a]pyrene diol epoxide in human cells in vivo
    Arito Yamane
    Biology Division, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo, Japan
    Carcinogenesis 24:1031-7. 2003
    ..These results indicate that OGG1 and MYH function as suppressors for G:C to T:A transversions by 8OHG but not by BPDE in human cells...
  42. doi request reprint KIF5B-RET fusions in lung adenocarcinoma
    Takashi Kohno
    Division of Genome Biology, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Nat Med 18:375-7. 2012
    ....
  43. doi request reprint Association of CYP19A1 polymorphisms with risks for atypical adenomatous hyperplasia and bronchioloalveolar carcinoma in the lungs
    Takashi Kohno
    Biology Division, National Cancer Center Research Institute Tokyo 104 0045, Japan
    Carcinogenesis 31:1794-9. 2010
    ..079) in a population of 363 postmenopausal women without cancer. These results indicate that CYP19A1 polymorphisms are involved in the risk for lung AAH and BAC in the lungs by causing differences in estrogen levels...
  44. ncbi request reprint Correlation between histone acetylation and expression of the MYO18B gene in human lung cancer cells
    Masachika Tani
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Genes Chromosomes Cancer 40:146-51. 2004
    ....
  45. ncbi request reprint Localization of a human lung adenocarcinoma susceptibility locus, possibly syntenic to the mouse Pas1 locus, in the vicinity of the D12S1034 locus on chromosome 12p11.2-p12.1
    Noriko Yanagitani
    Biology Division, National Cancer Center Research Institute, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 23:1177-83. 2002
    ..These results indicate that the PAS1 locus is located in the vicinity of D12S1034 and a genetic variation(s) at this locus is involved in susceptibility to human lung adenocarcinoma...
  46. doi request reprint Prevalence of human papillomavirus 16/18/33 infection and p53 mutation in lung adenocarcinoma
    Reika Iwakawa
    Division of Biology, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 101:1891-6. 2010
    ..These results indicate that HPV 16/18/33 infection does not play a major role in the development of lung AdC in Japan nor in the USA...
  47. ncbi request reprint Rapid assessment of two major repair activities against DNA double-strand breaks in vertebrate cells
    Shigeru Sasaki
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Biochem Biophys Res Commun 339:583-90. 2006
    ..Thus, this assay will be helpful in studies on mechanisms and inter-cellular variations of DSB repair...
  48. pmc NuMA is required for the selective induction of p53 target genes
    Hirokazu Ohata
    Division of Cancer Differentiation, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Mol Cell Biol 33:2447-57. 2013
    ..These data demonstrate that NuMA is critical for the target selectivity of p53-mediated transcription...
  49. doi request reprint Genome-wide identification of genes with amplification and/or fusion in small cell lung cancer
    Reika Iwakawa
    Division of Multistep Carcinogenesis, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Genes Chromosomes Cancer 52:802-16. 2013
    ....
  50. doi request reprint Contribution of germline mutations to PARK2 gene inactivation in lung adenocarcinoma
    Reika Iwakawa
    Division of Multistep Carcinogenesis, National Cancer Center Research Institute, Tokyo, Japan
    Genes Chromosomes Cancer 51:462-72. 2012
    ..These results strongly indicate that somatic PARK2 mutations occur rarely (or do not occur) in LADC development and that germline PARK2 mutations could contribute to LADC progression but not to LADC development...
  51. ncbi request reprint Establishment of human osteosarcoma cell lines with high metastatic potential to lungs and their utilities for therapeutic studies on metastatic osteosarcoma
    Kenji Kimura
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Clin Exp Metastasis 19:477-85. 2002
    ..These results indicate that both ADR and IL-12 are effective agents against pulmonary metastatic osteosarcoma, and that these sublines are useful for studies on the biological behavior and treatment of pulmonary metastatic osteosarcoma...
  52. pmc Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences
    Masami Kodama
    Radiobiology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Mol Cell Biol 30:1620-33. 2010
    ..These results suggest that ATM phosphorylates a noncanonical serine residue on p53 by mechanisms different from those for the phosphorylation of Ser15...
  53. doi request reprint The usefulness of mutation-specific antibodies in detecting epidermal growth factor receptor mutations and in predicting response to tyrosine kinase inhibitor therapy in lung adenocarcinoma
    Yoshiki Kozu
    Division of Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan
    Lung Cancer 73:45-50. 2011
    ..The ability to detecting such mutations using immunohistochemistry (IHC) would be advantageous...
  54. ncbi request reprint Frequent EGFR mutations in noninvasive bronchioloalveolar carcinoma
    Shingo Matsumoto
    Biology Division, National Cancer Center Research Institute, Tokyo, and Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, Japan
    Int J Cancer 118:2498-504. 2006
    ..EGFR mutations are present frequently in BACs, and are thus likely to be a critical genetic alteration for the formation of noninvasive lung adenocarcinoma...
  55. pmc Cancer susceptibility polymorphism of p53 at codon 72 affects phosphorylation and degradation of p53 protein
    Chikako Ozeki
    Radiobiology Division, National Cancer Center Research Institute, Tsukiji 5 1 1, Tokyo 104 0045, Japan
    J Biol Chem 286:18251-60. 2011
    ..Collectively, we demonstrate a novel molecular difference and simultaneously suggest a difference in the tumor-suppressing function of the variants...
  56. ncbi request reprint Causation of Borrmann type 4 gastric cancer: heritable factors or environmental factors?
    Ying Liu
    Cancer Information and Epidemiology Division, Research Institute, National Cancer Center, Tokyo 104 0045, Japan
    Gastric Cancer 6:17-23. 2003
    ..the study of family history and spousal history of cancer may play an important role in the assessment of causation of this severe gastric cancer...
  57. doi request reprint Deficiency of Myo18B in mice results in embryonic lethality with cardiac myofibrillar aberrations
    Rieko Ajima
    Biology Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Genes Cells 13:987-99. 2008
    ..5. Thus, Myo18B is a unique unconventional myosin that is predominantly expressed in myocytes and whose expression is essential for the development and/or maintenance of myofibrillar structure...
  58. ncbi request reprint Prevalent involvement of illegitimate V(D)J recombination in chromosome 9p21 deletions in lymphoid leukemia
    Yukiko Kitagawa
    Biology Division, National Cancer Center Research Institute, Tokyo 1040045, Japan
    J Biol Chem 277:46289-97. 2002
    ..These results indicated that illegitimate V(D)J recombination, which was targeted at several ectopic recombination signal sequences widely distributed in 9p21, caused a large fraction of 9p21 deletions in lymphoid leukemia...
  59. doi request reprint Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
    Tsutomu Ohta
    Center for Medical Genomics, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Cancer Res 68:1303-9. 2008
    ..Thus, inhibition of NRF2 may provide new therapeutic approaches in lung cancers with activation of Nrf2...
  60. doi request reprint Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma
    Mitsuhiro Yoneda
    Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Cancer Sci 100:225-32. 2009
    ..Taken together, we propose that ana functions as a tumor suppressor and that its product inhibits tumor progression as well by suppressing angiogenesis, invasion, and metastasis...
  61. doi request reprint Identification of a function-specific mutation of clathrin heavy chain (CHC) required for p53 transactivation
    Hirokazu Ohata
    Radiobiology Division, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    J Mol Biol 394:460-71. 2009
    ..Surprisingly, this mutation had little effect on receptor-mediated endocytosis. Thus, the function-specific mutation of CHC will clarify physiological roles of CHC in the regulation of the p53 pathway...
  62. doi request reprint Genetic basis for susceptibility to lung cancer: Recent progress and future directions
    Jun Yokota
    Biology Division, National Cancer Center Research Institute, Tsukiji, Chuo Ku, Tokyo, Japan
    Adv Cancer Res 109:51-72. 2010
    ....
  63. ncbi request reprint Involvement of Ku80 in microhomology-mediated end joining for DNA double-strand breaks in vivo
    Yukitaka Katsura
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    DNA Repair (Amst) 6:639-48. 2007
    ..The results suggest that the increase in DSBs makes the cell more predominant for MMEJ. MMEJ might function as a salvage pathway for DSBs that cannot be repaired by NHEJ...
  64. ncbi request reprint Molecular processes of chromosome 9p21 deletions causing inactivation of the p16 tumor suppressor gene in human cancer: deduction from structural analysis of breakpoints for deletions
    Takashi Kohno
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    DNA Repair (Amst) 5:1273-81. 2006
    ..Further structural analysis of other hot spots of chromosomal DNA breaks as well as the evaluation of the activity and specificity of NHEJ in human cells will elucidate the mechanisms of chromosome interstitial deletions in human cells...
  65. ncbi request reprint Evaluation of a whole-genome amplification method based on adaptor-ligation PCR of randomly sheared genomic DNA
    Chikako Tanabe
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Genes Chromosomes Cancer 38:168-76. 2003
    ..These data show that PRSG can provide a sufficient amount of genomic sequence for a variety of genetic analyses as well as for long-term storage for future work...
  66. ncbi request reprint Mutation and expression of the beta-catenin-interacting protein ICAT in human colorectal tumors
    Toru Koyama
    Second Department of Surgery, Gunma University School of Medicine, Maebashi, Laboratory of Molecular and Genetic Information, Institution of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
    Jpn J Clin Oncol 32:358-62. 2002
    ..We have recently identified the ICAT gene, which encodes a small protein that interacts with beta-catenin and represses Wnt signaling...
  67. ncbi request reprint Tyrosine phosphorylation of paxillin affects the metastatic potential of human osteosarcoma
    Kotaro Azuma
    Growth Factor Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Oncogene 24:4754-64. 2005
    ..These findings suggest that enhanced activity of Src family kinases and overexpression of paxillin synergistically contribute to the high metastatic potential of human osteosarcoma through the hyperphosphorylation of paxillin...
  68. ncbi request reprint [Genes involved in metastasis of lung cancer]
    Masachika Tani
    Biology Division, National Cancer Center Research Institute
    Nihon Rinsho 60:116-9. 2002
  69. ncbi request reprint Probing the chromosome 9p21 region susceptible to DNA double-strand breaks in human cells in vivo by restriction enzyme transfer
    Masanori Sato
    Biology Division, National Cancer Center Research Institute, Tokyo 1040045, Japan
    Oncogene 24:6108-18. 2005
    ..This method could help us understand the pathogenic significance of differential susceptibility to DSBs among genomic regions in human carcinogenesis...
  70. ncbi request reprint HOMER2 binds MYO18B and enhances its activity to suppress anchorage independent growth
    Rieko Ajima
    Biology Division, National Cancer Center Research Institute, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Biochem Biophys Res Commun 356:851-6. 2007
    ..Expression of HOMER2 enhanced the ability of MYO18B to suppress anchorage-independent growth. These results indicate that HOMER2 and MYO18B cooperate together in tumor suppression...
  71. ncbi request reprint [Genetic factors involved in cancer susceptibility]
    Takashi Kohno
    Biology Division, National Cancer Center Research Institute
    Gan To Kagaku Ryoho 29:1255-62. 2002
    ..Case-control studies, mainly focusing on the genes involved in drug metabolisms and DNA repair, have shown that dozens of genes are associated with cancer risks...
  72. pmc Frequent co-localization of Cox-2 and laminin-5 gamma2 chain at the invasive front of early-stage lung adenocarcinomas
    Toshiro Niki
    Pathology and Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Am J Pathol 160:1129-41. 2002
    ..Further investigations are warranted concerning the role of cox-2 and laminin-5 in cancer cell invasion and the significance of p53 and EGFR signaling in the regulation of cox-2 and laminin-5 expression...
  73. ncbi request reprint [Wnt signaling abnormalities in human lung cancer]
    Noriaki Sunaga
    Biology Division, National Cancer Center Research Institute
    Nihon Rinsho 60:733-6. 2002
  74. ncbi request reprint Alterations in the INK4a/ARF locus and their effects on the growth of human osteosarcoma cell lines
    Yong Bum Park
    Biology Division, National Cancer Center Research Institute, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo, Japan
    Cancer Genet Cytogenet 133:105-11. 2002
    ....
  75. ncbi request reprint Infrequent mutations of the activating transcription factor-2 gene in human lung cancer, neuroblastoma and breast cancer
    In Sook Woo
    Biology Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Oncol 20:527-31. 2002
    ..The present result indicates that the ATF-2 gene is not a major tumor suppressor gene on chromosome 2q, however, it is possible that ATF-2 alterations may be involved in the development of a small subset of lung cancers...
  76. ncbi request reprint A single nucleotide polymorphism at the splice donor site of the human MYH base excision repair genes results in reduced translation efficiency of its transcripts
    Satoru Yamaguchi
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Genes Cells 7:461-74. 2002
    ....
  77. ncbi request reprint OCIA domain containing 2 is highly expressed in adenocarcinoma mixed subtype with bronchioloalveolar carcinoma component and is associated with better prognosis
    Tadashi Ishiyama
    Department of Pathology, Institute of Basic Medical Science, Graduate School of Comprehensive Human Science, University of Tsukuba, 1 1 1 Tennoudai, Ibaraki shi, Ibaraki, Japan
    Cancer Sci 98:50-7. 2007
    ..These results suggest that OCIAD2 begins to express at the progression from in situ to invasive carcinoma, and is associated with the favorable prognosis of adenocarcinoma mixed subtype with BAC component...
  78. ncbi request reprint Full length and delta lactoferrin display differential cell localization dynamics, but do not act as tumor markers or significantly affect the expression of other genes
    Gary S Goldberg
    Department of Molecular Biology, University of Medicine and Dentistry of New Jersey, 2 Medical Center Drive, Stratford, NJ 08084, USA
    Med Chem 1:57-64. 2005
    ..Moreover, both forms of lactoferrin failed to substantially modulate the expression of other genes. Thus, lactoferrin does not seem to directly control gene expression or inhibit tumor cell growth...
  79. ncbi request reprint Restored expression of the MYO18B gene suppresses orthotopic growth and the production of bloody pleural effusion by human malignant pleural mesothelioma cells in SCID mice
    Nobutaka Edakuni
    Department of Internal Medicine and Molecular Therapeutics, University of Tokushima Graduate School, Tokushima 770 8503, Japan
    Oncol Res 16:235-43. 2006
    ..These findings suggest that the restored expression of MYO18B may be a useful therapeutic strategy for the treatment of locally advanced MPM in humans...
  80. pmc Reduced levels of ATF-2 predispose mice to mammary tumors
    Toshio Maekawa
    Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    Mol Cell Biol 27:1730-44. 2007
    ..Thus, ATF-2 acts as a tumor susceptibility gene of mammary tumors, at least partly, by activating a group of target genes, including Maspin and Gadd45alpha...
  81. ncbi request reprint Overexpression of autocrine motility factor receptor (AMFR) in NIH3T3 fibroblasts induces cell transformation
    Yasuharu Onishi
    Tumor Progression and Metastasis Program, Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Clin Exp Metastasis 20:51-8. 2003
    ..Interestingly, the enhanced expression of AMFR produced tumors in nude mice. Our findings provide a direct evidence that overexpression of the AMFR is associated with the acquisition of a transformation phenotype...
  82. ncbi request reprint EVI1 is expressed in megakaryocyte cell lineage and enforced expression of EVI1 in UT-7/GM cells induces megakaryocyte differentiation
    Seiichi Shimizu
    Department of Biochemistry, Miyazaki Medical College, Miyazaki, Japan
    Biochem Biophys Res Commun 292:609-16. 2002
    ....
  83. ncbi request reprint MYO18B interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway
    Takeshi Inoue
    Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, 3 8 1 Komaba, Tokyo 153 8902, Japan
    Biochem Biophys Res Commun 342:829-34. 2006
    ..Collectively, these results suggested that MYO18B is a substrate for proteasomal degradation...
  84. ncbi request reprint Suppression of chemically induced and spontaneously occurring oxidative mutagenesis by three alleles of human OGG1 gene encoding 8-hydroxyguanine DNA glycosylase
    Su Ryang Kim
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Mutat Res 554:365-74. 2004
    ..These results suggest that three alleles of the hOGG1 gene efficiently suppress chemically induced and spontaneously occurring oxidative mutagenesis, and that hOGG1-Gln46 may have a weaker ability to suppress the mutations...
  85. ncbi request reprint Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
    Nozomu Yanaihara
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Cell 9:189-98. 2006
    ..These results indicate that miRNA expression profiles are diagnostic and prognostic markers of lung cancer...
  86. ncbi request reprint Genetic polymorphism of CYP2A6 gene and tobacco-induced lung cancer risk in male smokers
    Noritaka Ariyoshi
    Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Cancer Epidemiol Biomarkers Prev 11:890-4. 2002
    ..These data suggest that male smokers possessing the *1A/*1A genotype have higher risk for tobacco-induced lung cancers...
  87. doi request reprint Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines
    Pedro P Medina
    Lung Cancer Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    Hum Mutat 29:617-22. 2008
    ..In conclusion, our data strongly support that BRG1 is a bona fide tumor suppressor and a major factor in lung tumorigenesis...
  88. ncbi request reprint Use of a cytokine gene expression signature in lung adenocarcinoma and the surrounding tissue as a prognostic classifier
    Masahiro Seike
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4258, USA
    J Natl Cancer Inst 99:1257-69. 2007
    ..We examined whether the cytokine gene expression profile of noncancerous lung tissue could predict the metastatic capability of adjacent lung adenocarcinoma...
  89. ncbi request reprint A novel splice-site variant of the base excision repair gene MYH is associated with production of an aberrant mRNA transcript encoding a truncated MYH protein not localized in the nucleus
    Hong Tao
    First Department of Pathology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka 431 3192, Japan
    Carcinogenesis 25:1859-66. 2004
    ....
  90. doi request reprint CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations
    Kyoung Mu Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 17:1120-6. 2008
    ..However, further investigation is warranted considering the relatively small sample size when subgroup analyses were done and the lack of environmental exposure data other than smoking...
  91. doi request reprint Down-regulation of TCF8 is involved in the leukemogenesis of adult T-cell leukemia/lymphoma
    Tomonori Hidaka
    Division of Tumor and Cellular Biochemistry, Department of Medical Sciences, University of Miyazaki, Miyazaki, Japan
    Blood 112:383-93. 2008
    ..These findings indicate that TCF8 has a tumor suppressor role in ATLL...