Research Topics
Species | Shoji YamamotoSummaryAffiliation: National Institute for Environmental Studies Country: Japan Publications
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Detail Information
Publications
Suppression of pulmonary antibacterial defenses mechanisms and lung damage in mice exposed to fluoride aerosolS Yamamoto
Regional Environment Division, National Institute for Environmental Studies, Tsukuba, Japan
J Toxicol Environ Health A 62:485-94. 2001..Data indicate that fluoride inhalation produces pulmonary cellular alterations that are associated with a diminished ability to cope with infectious bacteria...
Suppression of Th1- and Th2-type immune responses in infant mouse spleen after prenatal and postnatal exposure to low-level toluene and peptidoglycanShoji Yamamoto
National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Inhal Toxicol 21:793-802. 2009..These findings suggest that low-level toluene exposure and PGN stimulation from the late prenatal to early postnatal stage suppressed the splenic parameter related to Th1/Th2 immunity in infant mice...- Children's immunology, what can we learn from animal studies (2): Modulation of systemic Th1/Th2 immune response in infant mice after prenatal exposure to low-level toluene and toll-like receptor (TLR) 2 ligandShoji Yamamoto
National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
J Toxicol Sci 34:SP341-8. 2009..Our findings indicate that modulation of Th1- and Th2-responses may occur in low-level toluene exposure and/or combination with PGN stimulation in infant mice... - Effect of ultrafine carbon black particles on lipoteichoic acid-induced early pulmonary inflammation in BALB/c miceShoji Yamamoto
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
Toxicol Appl Pharmacol 213:256-66. 2006..We suggest that early pulmonary inflammatory responses in male BALB/c mice may be induced in a size-specific manner of the CB particles used in our study... - Athymic nude mice are insensitive to low-level toluene-induced up-regulation of memory-related gene expressions in the hippocampusTin Tin Win Shwe
National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
Neurotoxicology 28:957-64. 2007.... - Up-regulation of neurotrophin-related gene expression in mouse hippocampus following low-level toluene exposureTin Tin Win-Shwe
Research Center for Environmental Risk, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Neurotoxicology 31:85-93. 2010.... - Extracellular glutamate level and NMDA receptor subunit expression in mouse olfactory bulb following nanoparticle-rich diesel exhaust exposureTin Tin Win-Shwe
National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Inhal Toxicol 21:828-36. 2009..This is the first study to show the correlation between glutamate toxicity and memory function-related gene expressions in the mouse olfactory bulb following exposure to NRDE... - Nanoparticle-rich diesel exhaust affects hippocampal-dependent spatial learning and NMDA receptor subunit expression in female miceTin Tin Win-Shwe
Center for Environmental Risk Research, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki, Japan
Nanotoxicology 6:543-53. 2012..These results indicate that three months of exposure to NRDE affected spatial learning and memory function-related gene expressions in the female mouse hippocampus... - Effects of low-level formaldehyde exposure on synaptic plasticity-related gene expression in the hippocampus of immunized miceSohel Ahmed
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Ibaraki, Japan
J Neuroimmunol 186:104-11. 2007..These results indicate that FA exposure selectively up-regulates hippocampal gene expression in immunologically sensitized mice. The FA effects are presumably mediated by glutamatergic neurotransmission through NMDA receptors... - Role of CD4(+) T cells in the modulation of neurotrophin production in mice exposed to low-level tolueneHidekazu Fujimaki
National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Immunopharmacol Immunotoxicol 31:146-9. 2009..However, treatment with anti-CD4 mAb completely abrogated these effects. These findings suggest that the CD4(+) T cells may be involved in the toluene-induced modulation of neurotrophin production... - Modulation of neurological related allergic reaction in mice exposed to low-level tolueneShoji Yamamoto
Research Center for Environmental Risk, National Institute for Environmental Studies 16 2, Onogawa, Tsukuba, Ibaraki 305 8506, Japan
Toxicol Appl Pharmacol 222:17-24. 2007..These findings suggest that low-level toluene exposure aggravates the airway inflammatory responses in ovalbumin-immunized mice by modulating neuroimmune crosstalk... - Spatial learning and memory function-related gene expression in the hippocampus of mouse exposed to nanoparticle-rich diesel exhaustTin Tin Win-Shwe
National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
Neurotoxicology 29:940-7. 2008..These results indicate that co-exposure of NRDE and LTA could affect spatial learning and memory function-related gene expressions in mouse hippocampus... - Effect of long-term exposure to low-level toluene on airway inflammatory response in miceHidekazu Fujimaki
National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Toxicol Lett 168:132-9. 2007..Our findings suggest that long-term (12-week) exposure of mice to low-level toluene modulates airway inflammatory response via neurological signaling... - Effect of intratracheal instillation of ultrafine carbon black on proinflammatory cytokine and chemokine release and mRNA expression in lung and lymph nodes of miceTin Tin Win Shwe
National Institute for Environmental Studies, Environmental Health Sciences Division, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
Toxicol Appl Pharmacol 209:51-61. 2005.... - Strain differences in extracellular amino acid neurotransmitter levels in the hippocampi of major histocompatibility complex congenic mice in response to toluene exposureTin Tin Win-Shwe
Research Center for Environmental Risk, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Neuroimmunomodulation 16:185-90. 2009..The aim of the present study was to investigate the possible role of the major histocompatibility complex locus in neurotransmitter systems in the mouse hippocampus following toluene exposure... - Changes in neurotransmitter levels and proinflammatory cytokine mRNA expressions in the mice olfactory bulb following nanoparticle exposure- Tin-Tin-Win-Shwe
National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
Toxicol Appl Pharmacol 226:192-8. 2008..These findings suggest that nanoparticle CB may modulate the extracellular amino acid neurotransmitter levels and proinflammatory cytokine IL-1 beta mRNA expressions synergistically with LTA in the mice olfactory bulb... - The expression of nerve growth factor in mice lung following low-level toluene exposureHidekazu Fujimaki
National Institute for Environmental Studies, Tsukuba, Ibaraki, 305 8506, Japan
Toxicol Lett 191:240-5. 2009..These findings suggest that the exposure with volatile organic compounds enhanced NGF expression and airway inflammation stronger in allergic individuals than in healthy individuals... - Establishment of a mouse model to assess brain neurotransmitter level and learning performance simultaneously following toxic chemical exposure: using in vivo microdialysis and schedule-controlled operant behaviorTin Tin Win-Shwe
Research Center for Environmental Risk, National Institute for Environmental Studies, Onogawa, Tsukuba, Ibaraki 305 8506, Japan
J UOEH 31:1-11. 2009..This is the first time to establish a new method to assess the effect of environmental chemical exposure on the brain neurotransmitter level during learning performance in an animal model... - Brain cytokine and chemokine mRNA expression in mice induced by intranasal instillation with ultrafine carbon black- Tin-Tin-Win-Shwe
National Institute for Environmental Studies, Environmental Health Sciences Division, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
Toxicol Lett 163:153-60. 2006..To our knowledge, this is the first study to demonstrate region-specific brain cytokine and chemokine mRNA-induction in mice triggered by intranasal instillation of specific-sized ufCB, in a physiologically relevant condition... - Different sensitivity in expression of transcription factor mRNAs in congenic mice following exposure to low-level tolueneHidekazu Fujimaki
National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Inhal Toxicol 22:903-9. 2010..Although there may be other differences unrelated to H-2 locus between the congenic mice of the same background, the findings of the present study strongly suggest a possible role of H-2 locus in the toluene-induced immune disturbance... - Inhalation of low-level formaldehyde increases the Bcl-2/Bax expression ratio in the hippocampus of immunologically sensitized miceShinji Tsukahara
National Institute for Environmental Studies, Tsukuba, Japan
Neuroimmunomodulation 13:63-8. 2006..In the present study, we examined the effects of FA on apoptotic mechanisms regulating survival and death of cells and on N-methyl-D-aspartate (NMDA) receptors related to hippocampal functions in the mouse hippocampus... - Increased hippocampal mRNA expression of neuronal synaptic plasticity related genes in mice chronically exposed to toluene at a low-level human occupational-exposureSohel Ahmed
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Ibaraki, Japan
Neurotoxicology 28:168-74. 2007.... - Strain differences influence N-methyl-D-aspartate receptor subunit gene expression in the olfactory bulb of an allergic mouse model following toluene exposureTin Tin Win-Shwe
National Institute for Environmental Studies, Tsukuba, Japan
Neuroimmunomodulation 17:340-7. 2010..The present study explored whether differences in mouse strains influence N-methyl-D-aspartate (NMDA) receptor expression in the olfactory bulb after low-level toluene exposure... - Distinct requirements for interleukin-6 in airway inflammation induced by diesel exhaust in miceHidekazu Fujimaki
National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Immunopharmacol Immunotoxicol 28:703-14. 2006..These findings suggest that interleukin-6 plays a critical role in airway inflammatory responses induced by diesel exhaust inhalation... - The effect of high temperature on alveolar macrophage counts in bronchoalveolar lavage fluid of F344 ratsShoji Yamamoto
Environmental Health Sciences Division, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-0053, Japan
Exp Anim 51:505-8. 2002..The results might suggest that high temperature (35 degrees C) affects the pulmonary defense mechanism... - Effect of diesel exhaust on immune responses in C57BL/6 mice intranasally immunized with pollen antigenHidekazu Fujimaki
Environmental Health Sciences Division, National Institute for Environmental Studies, Onogawa, Tsukubashi, Ibaraki 305-8506, Japan
J UOEH 27:11-24. 2005..These facts indicate that concurrent exposure to allergen and diesel exhaust or diesel gas modulates chemokine production in cervical lymph nodes cells and antibody production in plasma differentially... - [Involvement of acidic carbohydrates in learning and memory]Shoji Yamamoto
Tanpakushitsu Kakusan Koso 48:934-9. 2003 - Molecular cloning and genomic analysis of mouse glucuronyltransferase involved in biosynthesis of the HNK-1 epitopeShoji Yamamoto
Department of Biological Chemistry and CREST Core Research for Educational Science and Technology Project, Japan Science and Technology Corporation, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
J Biochem 131:337-47. 2002..Thus, this minimal promoter region of GlcAT-P is suggested to be associated with the regulation of HNK-1 expression... - Mice deficient in nervous system-specific carbohydrate epitope HNK-1 exhibit impaired synaptic plasticity and spatial learningShoji Yamamoto
Department of Biological Chemistry and CREST Core Research for Educational Science and Technology Project, Japan Science and Technology Corporation, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
J Biol Chem 277:27227-31. 2002..This is the first evidence that the loss of a single non-reducing terminal carbohydrate residue attenuates brain higher functions... - [Biodistribution of ultrafine particles of titanium dioxide by intratracheal administration to mice]Nobumitsu Sakai
Department of Urban and Environmental Engineering, Graduate School of Engineering, Kyoto University, Nishigyo ku, Kyoto 615 8540, Japan
J UOEH 30:27-38. 2008..That diameter was about 1 microm. We concluded that the particles had aggregated before administration to mice, so they didn't invade the blood vessels or organs from the pulmonary alveolus in the lung...