Seiichiro Yamamoto

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..The original FFQ and the shorter versions have sufficient validity and reproducibility to be used in epidemiologic studies...

..We evaluated the relationship between isoflavone consumption and breast cancer risk among women in the Japan Public Health Center-Based Prospective Study on Cancer and Cardiovascular Diseases (JPHC Study)...

..By site, decreased risks were observed for cancers of the colon, liver, and pancreas in men and for cancer of the stomach in women. Increased daily physical activity may be beneficial in preventing cancer in a relatively lean population...

..The aim of this study was to analyze the risk factors for local and distant recurrence after intersphincteric resection (ISR) for very low rectal adenocarcinoma...

..Total colectomy with ileorectal anastomosis (IRA) for familial adenomatous polyposis (FAP) carries a potential risk of metachronous cancer in the residual rectum. This study evaluated the risk of cancer development in the residual rectum...

..We prospectively examined the association between daily total physical activity level (METs/day) and subsequent risk of all-cause mortality and mortalities from cancer, heart disease, and cerebrovascular disease...

..Surgical indication for stage IV colorectal cancer patients with bilobar hepatic metastases may be controversial...

..The purpose of this study was to evaluate the long-term efficacy of hepatic arterial infusion (HAI) chemotherapy and hepatectomy following HAI for such condition...

..We conducted a randomized, controlled trial at 24 hospitals in Japan to compare D2 lymphadenectomy alone with D2 lymphadenectomy plus PAND in patients undergoing gastrectomy for curable gastric cancer...

..We examined the clinicopathological characteristics of rectal cancer patients with lateral pelvic lymph node (LPLN) metastasis in order to clarify their associated prognostic factors...

..Thus, KRAS polymorphisms were indicated to be involved in risk for the development of AAHs that progress to ADC by causing differential KRAS oncogene expression in the lungs...

..To identify polymorphisms in DNA repair genes that affect responses to platinum-based doublet chemotherapy in patients with non-small-cell lung cancer (NSCLC)...

..By defining perineural invasion of colorectal cancer as invasion to Auerbach's plexus, we examined the usefulness of this pathologic finding as a prognostic factor...

..Patients with stage T4 rectal cancer are known to have poor survival and often require pelvic exenteration (PE). We describe the oncologic outcome of PE for patients with clinical T4 rectal cancer over a 30-year period...

..The study aims to investigate the association between leisure-time physical activity and breast cancer risk in consideration of tumor estrogen-receptor/progesterone-receptor status...

..Nevertheless, no prospective study from Asia has assessed blood or urine levels as biomarkers of isoflavone intake...

..To clarify the oncological outcome of rectal well-differentiated neuroendocrine tumors (W/D NETs), we examined the clinicopathological characteristics and prognosis of patients with this neoplasm...

..Therefore, we conducted a phase II study to evaluate the efficacy and toxicity of sequential treatment with methotrexate (MTX) and also 5-FU as second-line chemotherapy in patients with advanced gastric cancer...

..Therefore, significance of these functional polymorphisms was evaluated in a population, in which polymorphisms in the GWAS genes showed associations with lung SQC risk...

..The aim of this study was to evaluate accuracy of high-resolution magnetic resonance imaging (HRMRI) for preoperative staging of rectal cancer...

..Mucinous adenocarcinoma (MUC) is a histological variant of colorectal adenocarcinoma. The aim of the present study was to characterize clinicopathological features and identify prognostic factors of MUCs...

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..CONCLUSION: Despite changes in intake levels for many nutrients, the validity of our FFQ using rank correlation by nutrient intake was not influenced by revision of the nutrient database in Japan...

..We performed a prospective study to examine the usefulness of these features as prognostic factors...

..76 (95% CI = 2.53-9.47, P = 4.2 x 10(-7)). The present results indicated that individuals susceptible to lung ADC can be defined by combined genotypes of HLA-DQA1 and TERT...

..Possible effect modification by CagA status, and serum pepsinogen status, as a marker of atrophic gastritis, was also considered to see its effect on developing gastric cancer. Subjects and..

..The aim of the study is to evaluate the current status of treatment-related death (TRD) in lung cancer patients...

..In addition, the presence of signet-ring cells is a non-significant indicator of a poor prognosis...

..Correlation coefficients for reproducibility ranged from 0.42 to 0.82, similar to those of Cohort I...

..Conclusion: CD10 mRNA showed significantly higher expression in tumor tissues than in matched normal tissues. Although CD10 mRNA was associated with invasion depth, lymph node status and TNM stage, it was not associated with prognosis...

..The aim of this study was to evaluate the incidence and patterns of recurrence, or oncologic safety, after intersphincteric resection (ISR) without radiotherapy for very low rectal adenocarcinoma...

..This study was designed to evaluate short-term outcomes and risk factors for conversion to open operation in laparoscopic operations for rectal carcinoma...

..This study investigated appropriate level of upward lymph node (LN) dissection in advanced lower rectal carcinoma...

..The aim of this study was to evaluate various clinical parameters that would influence the occurrence of wound infection (WI) in elective laparoscopic surgery (LS) for colorectal carcinoma...

..This study aims to search for independent predictors of lateral node metastasis in low rectal cancers...

..These findings support the Japanese social belief that "liver holidays," abstaining from alcohol for more than 2 days per week, are important for heavy drinkers...

..For simultaneous abdominal primary malignancies, laparoscopic surgery should be considered proactively if the procedure is technically feasible and judged to be curative...

..Surgery is indicated for patients with adverse factors...

..On the basis of a retrospective review, we aimed to clarify the optimum extent of lymph node dissection in patients with cT1 and cT2 colorectal cancer...

..No anastomotic leakage was observed. Laparoscopic intracorporeal rectal transection with double-stapling technique anastomosis can be performed safely without increased morbidity or mortality...

..Laparoscopic appendectomy and partial cecectomy was performed, and on pathologic examination, thickening and fibrosis of the muscle layer owing to endometriosis were judged to have caused intussusception-like changes...

..This study evaluated the risk factors for anastomotic leakage after laparoscopic surgery for rectal cancer using a stapling technique...

..We investigated multiple primary malignancies occurring in a large number of colorectal carcinoma patients who had undergone surgery in the 1980s at our institution...

..The purpose of this study was to evaluate the results of ASR for posterior pelvic recurrence of rectal carcinoma and to analyze prognostic factors and recurrence patterns...

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..In addition, the value of CEA in postoperative surveillance is discussed...

..In this study, we verified the accuracy of EGFR mutation analysis in small samples by high-resolution melting analysis (HRMA), which is a rapid method using PCR amplification with a dye to analyze the melting curves in NSCLC...

..06). Our results suggest that even for RRs, the extrapolation of estimates for a sample from a well-defined population to a general population may not be possible...

..The aim of the present study was to investigate the difference in surgical outcomes between laparoscopic surgery for transverse/descending colon carcinomas and that for other colon carcinomas...

..To evaluate the short-term surgical outcomes of laparoscopic intersphincteric resection (ISR) for lower rectal cancer, and to compare them with a case-control series of open ISR...

..The coexistence of two huge abdominal tumors as potential causes of PE and DVT is extremely rare, and we could have safely undergone the operation, using two vena cava filters in the supra- and infrarenal IVC...

..We report a rare case of recurrent advanced colonic cancer diagnosed 11 years after initial EPMR treatment...

..There is no consensus on the indication of surgical treatment for adenocarcinoid tumor. However, in advanced cases, an aggressive surgical procedure might result in long-term survival when resectable...

..We report the first case of isolated right external iliac lymph node recurrence from a primary cecum carcinoma, successfully treated by surgical resection...

..There were no deaths in either group. Advanced age should not be regarded as a contraindication for laparoscopic colonic surgery...

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..The purpose of this study is to investigate the authenticity of these models by comparison of accumulated genetic alterations between primary and corresponding metastatic lung cancers...

..Laparoscopic surgery is oncologically appropriate at least for patients with pT1 and pT2 colorectal carcinoma...

..These results need to be confirmed and validated in another data set or future prospective trial according to the scoring scheme we outline...

..The objectives of our study were to 1) validate a FFQ for estimating folate intake, and to identify the foods that contribute to inter-individual variation of folate intake in the Japanese population...

..Morbidity and mortality rates and oncologic outcome appear to be comparable with conventional surgery...

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..The objective of our study was to investigate the association between supplement use and demographics, lifestyles, health characteristics, and dietary intake in a population-based cohort study in Japan...

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..EGFR mutations are present frequently in BACs, and are thus likely to be a critical genetic alteration for the formation of noninvasive lung adenocarcinoma...

..This study aimed to examine this association in Japan by improving measurement techniques, and by extending measurement to a whole week...

..In addition, women may benefit from risk reduction if they consume at least moderate amounts of isoflavones...

..0 (95% CI: 1.2-3.2, P=0.002). The present results indicate that inter-individual differences in MTH1 activities due to SNPs are involved in susceptibility to SCLC...

..2-52.5%). CONCLUSIONS: Sequential MTX/5FU therapy is effective against AGC with malignant ascites with acceptable toxicity and warrants further investigations in a phase III setting...

..This study was undertaken to evaluate the long-term prognostic significance of conventional peritoneal cytology in patients with advanced colorectal carcinoma after curative resection...

..We conducted a randomized controlled trial to compare the Japanese standard D2 and D2 + para-aortic nodal dissection...

..The risk-benefit ratio must be carefully considered...

..06-0.77). We found no remarkable difference for the rs743572 and rs10046 polymorphisms. Our findings suggest that polymorphisms in the 17beta-HSD1 and SHBG genes may modify the association between isoflavone intake and breast cancer risk...

..The aim of this study was to perform a retrospective analysis of the risk factors for anastomotic leakage following intersphincteric resection (ISR) for very low rectal cancer...

..Progression-free survival (PFS) is a common endpoint in cancer clinical trials. This study was undertaken to assess the impact of data errors and data handling on the statistical estimation of PFS...

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..We are currently conducting a double-blind randomized controlled trial comparing bLF with placebo to clarify the anti-HCV activity of bLF in patients with CH-C...

..This study investigated prognostic factors in patients with advanced hepatocellular carcinoma treated by transcatheter arterial embolization...

..The aim of the present study was to project cancer mortality among Japanese males under different future scenarios of smoking prevalence...

..Effectiveness trials are a fundamental step toward bridging the gap between clinical research and clinical practice and effectively implementing new therapies in clinical practice...

..To compare fluorouracil (FU) alone with FU plus cisplatin (FP) and with uracil and tegafur plus mitomycin (UFTM) for patients with advanced gastric cancer in a prospective, randomized, controlled trial...

..To investigate the relationship between green tea consumption and subsequent risk of gastric cancer at different anatomical subsites in a population-based prospective study...

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..6; 95% CI = 1.3-5.2) but not in postmenopausal women (RR = 0.7; 95% CI = 0.4-1.0). We conclude that tobacco smoking increases the risk of female breast cancer in premenopausal women...

..Secondary end-points are relapse-free survival, short-term clinical outcome, adverse events, the rate of histologically curative operation, the proportion of completion of LS and the conversion rate...

..To clarify the indications for preoperative adjuvant radiotherapy for rectal cancer, the outcome of patients who underwent curative surgery without adjuvant radiotherapy was investigated...

..The virologic responses were not different between two groups in any subgroup analysis. In conclusion, orally administered bLF does not demonstrate any significant efficacy in patients with chronic hepatitis C...

..The current study was performed to quantify the risk of development of multiple primary malignancies in adult patients with soft tissue sarcoma...

..If contraindications of laparoscopy are not present, laparoscopic resection can be performed safely and should be considered for diagnosis and treatment for intussusception in ileocecal lesions in adults...

..There is no guideline for the treatment of patients with isolated lateral lymph node recurrence; however, surgery should be considered for such patients...

..43 (95% CI = 1.11-1.84, P = 0.0045). These results indicate that OGG1-326Cys functions as a risk allele for lung ADC development...

..CONCLUSIONS: LS for rectal carcinoma provides benefits during the early postoperative period without increase in morbidity or mortality...

..The predictive value of histologic grading and staging systems for overall survival in different types of adult soft tissue sarcoma of the extremities and trunk is unclear...

..The impact of overweight on the outcome of gastrectomy with lymphadenectomy is controversial, and data from a well-controlled, randomized study are needed to identify a possible relationship...

..CONCLUSIONS: Irinotecan plus cisplatin is an effective treatment for metastatic small-cell lung cancer...

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..The present study consists of a phase II trial of a cisplatin (CDDP)/5-fluorouracil (5-FU) infusion with concurrent radiotherapy in patients with unresectable, advanced esophageal cancer...