Tesshi Yamada

Summary

Affiliation: National Cancer Center
Country: Japan

Publications

  1. pmc Altered plasma apolipoprotein modifications in patients with pancreatic cancer: protein characterization and multi-institutional validation
    Kazufumi Honda
    Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo, Japan
    PLoS ONE 7:e46908. 2012
  2. ncbi request reprint Traf2- and Nck-interacting kinase is essential for Wnt signaling and colorectal cancer growth
    Miki Shitashige
    Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 70:5024-33. 2010
  3. doi request reprint Combined functional genome survey of therapeutic targets for hepatocellular carcinoma
    Reiko Satow
    Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Clin Cancer Res 16:2518-28. 2010
  4. pmc Survival prediction for pancreatic cancer patients receiving gemcitabine treatment
    Junichi Matsubara
    Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan mail
    Mol Cell Proteomics 9:695-704. 2010
  5. doi request reprint Reduced argininosuccinate synthetase is a predictive biomarker for the development of pulmonary metastasis in patients with osteosarcoma
    Eisuke Kobayashi
    Chemotherapy Division, National Cancer Centre Research Institute, Chuo Ku, Tokyo, Japan
    Mol Cancer Ther 9:535-44. 2010
  6. ncbi request reprint Involvement of splicing factor-1 in beta-catenin/T-cell factor-4-mediated gene transactivation and pre-mRNA splicing
    Miki Shitashige
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 132:1039-54. 2007
  7. ncbi request reprint Regulation of Wnt signaling by the nuclear pore complex
    Miki Shitashige
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 134:1961-71, 1971.e1-4. 2008
  8. ncbi request reprint Large-scale quantitative clinical proteomics by label-free liquid chromatography and mass spectrometry
    Ayako Negishi
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 100:514-9. 2009
  9. doi request reprint Quantitative proteomics using formalin-fixed paraffin-embedded tissues of oral squamous cell carcinoma
    Ayako Negishi
    Chemotherapy Division, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Cancer Sci 100:1605-11. 2009
  10. pmc Prolyl 4-hydroxylation of alpha-fibrinogen: a novel protein modification revealed by plasma proteomics
    Masaya Ono
    Chemotherapy Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Biol Chem 284:29041-9. 2009

Collaborators

Detail Information

Publications59

  1. pmc Altered plasma apolipoprotein modifications in patients with pancreatic cancer: protein characterization and multi-institutional validation
    Kazufumi Honda
    Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo, Japan
    PLoS ONE 7:e46908. 2012
    ..Among the more common human malignancies, invasive ductal carcinoma of the pancreas has the worst prognosis. The poor outcome seems to be attributable to difficulty in early detection...
  2. ncbi request reprint Traf2- and Nck-interacting kinase is essential for Wnt signaling and colorectal cancer growth
    Miki Shitashige
    Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 70:5024-33. 2010
    ..Our findings suggest TNIK as a feasible target for pharmacologic intervention to ablate aberrant Wnt signaling in colorectal cancer...
  3. doi request reprint Combined functional genome survey of therapeutic targets for hepatocellular carcinoma
    Reiko Satow
    Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Clin Cancer Res 16:2518-28. 2010
    ..The outcome of patients with advanced hepatocellular carcinoma (HCC) has remained unsatisfactory. Patients with HCC suffer from chronic hepatitis or liver cirrhosis, and their reserve liver function is often limited...
  4. pmc Survival prediction for pancreatic cancer patients receiving gemcitabine treatment
    Junichi Matsubara
    Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan mail
    Mol Cell Proteomics 9:695-704. 2010
    ..Although an external validation study will be necessary, the current model may be useful for identifying patients unsuitable for the standardized therapy...
  5. doi request reprint Reduced argininosuccinate synthetase is a predictive biomarker for the development of pulmonary metastasis in patients with osteosarcoma
    Eisuke Kobayashi
    Chemotherapy Division, National Cancer Centre Research Institute, Chuo Ku, Tokyo, Japan
    Mol Cancer Ther 9:535-44. 2010
    ..Our data indicate that in patients with osteosarcoma, reduced expression of ASS is not only a novel predictive biomarker for the development of metastasis, but also a potential target for pharmacologic intervention...
  6. ncbi request reprint Involvement of splicing factor-1 in beta-catenin/T-cell factor-4-mediated gene transactivation and pre-mRNA splicing
    Miki Shitashige
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 132:1039-54. 2007
    ....
  7. ncbi request reprint Regulation of Wnt signaling by the nuclear pore complex
    Miki Shitashige
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 134:1961-71, 1971.e1-4. 2008
    ..However, beta-catenin has no nuclear localization signal, and the mechanisms by which beta-catenin is imported into the nucleus and forms a complex with the TCF-4 nuclear protein are poorly understood...
  8. ncbi request reprint Large-scale quantitative clinical proteomics by label-free liquid chromatography and mass spectrometry
    Ayako Negishi
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 100:514-9. 2009
    ..2DICAL was is highly advantageous for large-scale clinical proteomics because of its simple procedure, high throughput, and quantification accuracy...
  9. doi request reprint Quantitative proteomics using formalin-fixed paraffin-embedded tissues of oral squamous cell carcinoma
    Ayako Negishi
    Chemotherapy Division, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Cancer Sci 100:1605-11. 2009
    ....
  10. pmc Prolyl 4-hydroxylation of alpha-fibrinogen: a novel protein modification revealed by plasma proteomics
    Masaya Ono
    Chemotherapy Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Biol Chem 284:29041-9. 2009
    ..Prolyl-hydroxylated alpha-fibrinogen is presumably controlled by multiple biological mechanisms, which remain to be clarified in future studies...
  11. doi request reprint β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells
    Reiko Satow
    Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 142:572-81. 2012
    ..However, genetic alteration of PML is rarely observed in these tumors; the exact mechanisms that mediate loss of PML function are not known...
  12. doi request reprint Identification of adipophilin as a potential plasma biomarker for colorectal cancer using label-free quantitative mass spectrometry and protein microarray
    Junichi Matsubara
    Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 20:2195-203. 2011
    ..The aim of this study was to identify a new plasma biomarker for use in early detection of colorectal cancer...
  13. ncbi request reprint Functional interaction of DNA topoisomerase IIalpha with the beta-catenin and T-cell factor-4 complex
    Lin Huang
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 133:1569-78. 2007
    ..DNA topoisomerase IIalpha (Topo IIalpha) is a component of the beta-catenin/T-cell factor-4 (TCF-4) nuclear complex. We examined the functional significance of Topo IIalpha in Wnt signaling...
  14. doi request reprint Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas
    Satoru Kikuchi
    Chemotherapy Division, Cancer Proteomics Project, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Clin Cancer Res 14:5348-56. 2008
    ..Actinin-4 is an actin-binding protein associated with enhanced cell motility, invasive growth, and lymph node metastasis. Actinin-4 might play an important role in the development and progression of pancreatic cancer...
  15. doi request reprint MicroRNA expression and functional profiles of osteosarcoma
    Eisuke Kobayashi
    Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo, Japan
    Oncology 86:94-103. 2014
    ..In order to develop new therapeutic approaches, elucidation of the entire molecular pathway regulating OS cell proliferation would be desirable...
  16. ncbi request reprint Label-free quantitative proteomics using large peptide data sets generated by nanoflow liquid chromatography and mass spectrometry
    Masaya Ono
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Mol Cell Proteomics 5:1338-47. 2006
    ..39 and correlation coefficient of over 0.92 between duplicates), and accurate quantification with a wide dynamic range (over 10(3)) of our platform warrant its application to various types of experimental and translational proteomics...
  17. doi request reprint Functional genome screen for therapeutic targets of osteosarcoma
    Umio Yamaguchi
    Chemotherapy Division, National Cancer Centre Research Institute, Tokyo, Japan
    Cancer Sci 100:2268-74. 2009
    ..Recently, phase I clinical trials of PLK1 chemical inhibitors have been reported. Our results indicate that PLK1 is a promising molecular target for pharmacologic intervention in OS...
  18. ncbi request reprint Plasma proteomics of pancreatic cancer patients by multi-dimensional liquid chromatography and two-dimensional difference gel electrophoresis (2D-DIGE): up-regulation of leucine-rich alpha-2-glycoprotein in pancreatic cancer
    Tatsuhiko Kakisaka
    Proteome Bioinformatics Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 852:257-67. 2007
    ..Our results demonstrate the application of a combination of multi-dimensional liquid chromatography with 2D-DIGE for plasma proteomics and suggest the clinical utility of LRG plasma level measurement...
  19. ncbi request reprint Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling
    Masashi Idogawa
    Chemotherapy Division and ADP Ribosylation in Oncology Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Res 67:911-8. 2007
    ..Identification of the functional interaction of Ku70 as well as PARP-1 with the TCF-4 and beta-catenin transcriptional complex may provide insights into a novel linkage between DNA damage recognition/repair and Wnt signaling...
  20. doi request reprint Combined functional genome survey of therapeutic targets for clear cell carcinoma of the kidney
    Hideaki Ito
    Division of Chemotherapy and Clinical Research, National Cancer Centre Research Institute, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 41:847-53. 2011
    ..The aim of this study was to catalog potential therapeutic target molecules for renal cell carcinoma...
  21. doi request reprint Plasma biomarker discovery and validation for colorectal cancer by quantitative shotgun mass spectrometry and protein microarray
    Yusuke Murakoshi
    Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 102:630-8. 2011
    ..01×10(-3) and P=1.13×10(-5) , respectively). Although the significance of the present study must be validated in an independent clinical study, the increment of plasma C9 may be applicable to the early detection of colorectal cancer...
  22. ncbi request reprint E-cadherin regulates the association between beta-catenin and actinin-4
    Yasuharu Hayashida
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 65:8836-45. 2005
    ..Shutting down the signals mediating this association may be worth considering as a therapeutic approach to cancer invasion and metastasis...
  23. ncbi request reprint Beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing
    Satoshi Sato
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 129:1225-36. 2005
    ..In this study, we used a proteomics approach to obtain further insight into the functional properties of nuclear beta-catenin...
  24. ncbi request reprint Possible detection of pancreatic cancer by plasma protein profiling
    Kazufumi Honda
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute 5 1 1 Tsukiji Chuoh ku, Tokyo, Japan
    Cancer Res 65:10613-22. 2005
    ..Although a multi-institutional large-scale study will be necessary to confirm clinical significance, the biomarker set identified in this study may be applicable to using plasma samples to diagnose pancreatic cancer...
  25. ncbi request reprint Mass spectrometry analysis of the native protein complex containing actinin-4 in prostate cancer cells
    Tomohiko Hara
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Tokyo 104 0045, Japan
    Mol Cell Proteomics 6:479-91. 2007
    ..The decreased expression of actinin-4 protein in prostate cancer cells may cause aberrations in the intracellular trafficking of various cell surface molecules and contribute to carcinogenesis...
  26. ncbi request reprint Increased susceptibility of Sf1(+/-) mice to azoxymethane-induced colon tumorigenesis
    Miki Shitashige
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 98:1862-7. 2007
    ..The increased susceptibility of Sf1(+/-) mice to AOM-induced colon tumorigenesis indicates the crucial involvement of SF1 in the beta-catenin-mediated regulation of proliferation and differentiation of intestinal epithelial cells...
  27. ncbi request reprint Database of two-dimensional polyacrylamide gel electrophoresis of proteins labeled with CyDye DIGE Fluor saturation dye
    Kazuyasu Fujii
    Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Proteomics 6:1640-53. 2006
    ....
  28. pmc Traf2- and Nck-interacting kinase is essential for canonical Wnt signaling in Xenopus axis formation
    Reiko Satow
    Chemotherapy Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    J Biol Chem 285:26289-94. 2010
    ..These results demonstrate that XTNIK is an essential factor for the transcriptional activity of the beta-catenin-TCF complex and dorsal axis determination in Xenopus embryos...
  29. doi request reprint Proteomic approaches to the discovery of cancer biomarkers for early detection and personalized medicine
    Kazufumi Honda
    Department of Chemotherapy and Clinical Research, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 43:103-9. 2013
    ..In this review, we introduce the proteomic platforms that are currently being used for cancer biomarker discovery, and describe examples of novel cancer biomarkers that were identified with each proteomic technology...
  30. ncbi request reprint Possible prediction of chemoradiosensitivity of esophageal cancer by serum protein profiling
    Yasuharu Hayashida
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo Medical University, Tokyo, Japan
    Clin Cancer Res 11:8042-7. 2005
    ..We investigated whether proteomic profiles of serum samples obtained from untreated patients were capable of being used to predict the efficacy of combined preoperative chemoradiotherapy against esophageal cancer...
  31. ncbi request reprint Serum albumin-associated peptides of patients with uterine endometrial cancer
    Satoru Kikuchi
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tsukiji, Tokyo, Japan
    Cancer Sci 98:822-9. 2007
    ....
  32. doi request reprint Distinct gene expression-defined classes of gastrointestinal stromal tumor
    Umio Yamaguchi
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    J Clin Oncol 26:4100-8. 2008
    ..GISTs are considered to invariably arise through gain of function KIT or PDGFA mutation of the interstitial cells of Cajal (ICC). However, the genetic basis of the malignant progression of GISTs are poorly understood...
  33. doi request reprint CXCL17 and ICAM2 are associated with a potential anti-tumor immune response in early intraepithelial stages of human pancreatic carcinogenesis
    Nobuyoshi Hiraoka
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 140:310-21. 2011
    ..We investigated when and how the human anti-tumor immune reaction changes during pancreatic tumor development...
  34. ncbi request reprint [Biological role of actinin-4 for cancer invasion and metastasis]
    Kazufumi Honda
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Seikagaku 79:643-54. 2007
  35. ncbi request reprint Protein expression pattern distinguishes different lymphoid neoplasms
    Kazuyasu Fujii
    Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Proteomics 5:4274-86. 2005
    ..These proteins may have potential as differential diagnostic markers for lymphoid neoplasms...
  36. doi request reprint Reduced plasma level of CXC chemokine ligand 7 in patients with pancreatic cancer
    Junichi Matsubara
    Chemotherapy Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Epidemiol Biomarkers Prev 20:160-71. 2011
    ..Early detection is essential to improve the outcome of patients with pancreatic cancer. A noninvasive and cost-effective diagnostic test using plasma/serum biomarkers would facilitate the detection of pancreatic cancer at the early stage...
  37. doi request reprint Identification of a predictive biomarker for hematologic toxicities of gemcitabine
    Junichi Matsubara
    Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    J Clin Oncol 27:2261-8. 2009
    ..This study aimed to discover a new diagnostic method for predicting the hematologic toxicities of gemcitabine...
  38. pmc Biomarker Discovery of Pancreatic and Gastrointestinal Cancer by 2DICAL: 2-Dimensional Image-Converted Analysis of Liquid Chromatography and Mass Spectrometry
    Masaya Ono
    Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Int J Proteomics 2012:897412. 2012
    ....
  39. pmc MicroRNA-143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease-13 expression
    Mitsuhiko Osaki
    Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan
    Mol Ther 19:1123-30. 2011
    ....
  40. doi request reprint Wnt signaling inside the nucleus
    Miki Shitashige
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuoh ku, Tokyo 104 0045, Japan
    Cancer Sci 99:631-7. 2008
    ..We also summarize current strategies in the development of drugs against Wnt signaling...
  41. ncbi request reprint Two-dimensional electrophoresis database of fluorescence-labeled proteins of colon cancer cells
    Yasuharu Mori
    Cancer Proteomics Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Tokyo 104 0045, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 823:82-97. 2005
    ..Proteins of DLD-1 cells and of laser-microdissected colon cancer tissues showed similar distribution on 2D gels, suggesting the utility of our database for clinical proteomics...
  42. ncbi request reprint Morphological and transcriptional responses of untransformed intestinal epithelial cells to an oncogenic beta-catenin protein
    Yasuyoshi Naishiro
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Oncogene 24:3141-53. 2005
    ..The IGFBP2 protein interacts with integrins. Disruption of the multigene network system regulating cell adhesion and cytoskeleton may be crucial in the initiation of colorectal carcinogenesis...
  43. ncbi request reprint Copy number increase of ACTN4 is a prognostic indicator in salivary gland carcinoma
    Yukio Watabe
    Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo, 104 0045, Japan Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Chiba, 261 8502, Japan
    Cancer Med 3:613-22. 2014
    ..98-28.06) and CNI of ACTN4 (HR: 3.23; 95% CI: 1.08-9.68) remained as risk factors for cancer death in multivariate analysis. Thus, CNI of ACTN4 is a novel indicator for an unfavorable outcome in patients with salivary gland carcinoma...
  44. pmc Alternative mammalian target of rapamycin (mTOR) signal activation in sorafenib-resistant hepatocellular carcinoma cells revealed by array-based pathway profiling
    Mari Masuda
    From the Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo, 104 0045 Japan
    Mol Cell Proteomics 13:1429-38. 2014
    ..p-RPS6 S235/236 is a potential biomarker that predicts unresponsiveness of HCC to sorafenib. The use of mTOR inhibitors may be considered for the treatment of such tumors. ..
  45. doi request reprint Developments for a growing Japanese patient population: facilitating new technologies for future health care
    Harubumi Kato
    Dept of Surgery, Tokyo Medical University, Tokyo, Japan
    J Proteomics 74:759-64. 2011
    ....
  46. doi request reprint SOX10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors: a clue to the histogenesis for tumor diagnosis
    Rie Ohtomo
    Department of Pathology and Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan
    Mod Pathol 26:1041-50. 2013
    ..Thus, SOX10 is a novel marker for diagnosing and understanding the histogenesis of salivary gland tumors...
  47. pmc Carbonic anhydrase I as a new plasma biomarker for prostate cancer
    Michiko Takakura
    Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    ISRN Oncol 2012:768190. 2012
    ..CAI can potentially serve as a valuable plasma biomarker and the combination of PSA and CAI may have great advantages for diagnosing prostate cancer in patients with gray-zone PSA level...
  48. ncbi request reprint Nemo-like kinase suppresses a wide range of transcription factors, including nuclear factor-kappaB
    Jun Yasuda
    Cancer Transcriptome Project, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 95:52-7. 2004
    ..The extent of suppression by NLK was similar among the transcription factors tested (50-60% reduction). Our results suggest that NLK may suppress a wide range of gene expression, possibly through CBP...
  49. ncbi request reprint Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice
    Tesshi Yamada
    Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Cancer Res 63:895-901. 2003
    ..Inhibitors of P-glycoprotein may be included in a novel class of chemopreventive agents against colorectal carcinogenesis...
  50. ncbi request reprint Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells
    Jun Yasuda
    Cancer Transcriptome Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Biochem Biophys Res Commun 308:227-33. 2003
    ..Apoptosis induction by wild-type NLK was confirmed using TUNEL assays. Our results suggest that overexpression of NLK may have targets other than TCF for induction of apoptosis in human colon carcinoma cells...
  51. ncbi request reprint Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex
    Masashi Idogawa
    Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 128:1919-36. 2005
    ..We explored the molecular composition of the TCF-4/beta-catenin transcriptional complex by means of proteomics...
  52. ncbi request reprint Identification of 2 serum biomarkers of renal cell carcinoma by surface enhanced laser desorption/ionization mass spectrometry
    Tomohiko Hara
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tsukiji, Tokyo, Japan
    J Urol 174:1213-7. 2005
    ..In this study we identified novel diagnostic biomarkers of renal cell carcinoma (RCC) by large-scale serum protein profiling using surface enhanced laser desorption/ionization mass spectrometry...
  53. ncbi request reprint Proteomic signatures for histological types of lung cancer
    Masahiro Seike
    Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Proteomics 5:2939-48. 2005
    ..In conclusion, our results demonstrate the utility of quantitative proteomic analysis for molecular diagnosis and classification of lung cancer cells...
  54. doi request reprint Immunohistochemical actinin-4 expression in infiltrating gliomas: association with WHO grade and differentiation
    Shintaro Fukushima
    Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    Brain Tumor Pathol 31:11-6. 2014
    ..Although diagnostic utility of this marker awaits future exploration, actinin-4 may help distinguish between astrocytic and oligodendroglial lines of differentiation. ..
  55. doi request reprint Soluble interleukin-6 receptor is a serum biomarker for the response of esophageal carcinoma to neoadjuvant chemoradiotherapy
    Yosuke Makuuchi
    Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 104:1045-51. 2013
    ..Persistent systemic inflammation is implicated as a possible mechanism of resistance to this therapy...
  56. ncbi request reprint Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma
    Nobuhiro Nitori
    Pathology, National Cancer Center Research Institute, Tokyo, Japan
    Clin Cancer Res 11:2531-9. 2005
    ....
  57. pmc Galectin-7 as a potential predictive marker of chemo- and/or radio-therapy resistance in oral squamous cell carcinoma
    Sho Matsukawa
    Oral and Maxillofacial Surgery, Department of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8510, Japan
    Cancer Med 3:349-61. 2014
    ..Therefore, our findings suggest that galectin-7 is a potential predictive marker of chemotherapy and/or radiotherapy resistance in patients with OSCC. ..
  58. ncbi request reprint Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma
    Yoshio Tomizawa
    Biology Division, Pathology Division, National Cancer Center Hospital, Tokyo 104 0045, Japan
    Clin Cancer Res 8:2362-8. 2002
    ..In this study, we investigated the pathogenetic and clinicopathological significances of RASSF1A methylation in the development and/or progression of lung adenocarcinoma...
  59. ncbi request reprint Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer
    Kazufumi Honda
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuoh ku, Tokyo 104 0045, Japan
    Gastroenterology 128:51-62. 2005
    ..However, its involvement in the mechanisms of cancer invasion and metastasis remains undetermined. The current study tested the role of actinin-4 in the motility and metastatic potential of colorectal cancer cells...