Tesshi Yamada

Summary

Affiliation: National Cancer Center
Country: Japan

Publications

  1. doi request reprint Combined functional genome survey of therapeutic targets for clear cell carcinoma of the kidney
    Hideaki Ito
    Division of Chemotherapy and Clinical Research, National Cancer Centre Research Institute, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 41:847-53. 2011
  2. ncbi request reprint Morphological and transcriptional responses of untransformed intestinal epithelial cells to an oncogenic beta-catenin protein
    Yasuyoshi Naishiro
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Oncogene 24:3141-53. 2005
  3. ncbi request reprint Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells
    Jun Yasuda
    Cancer Transcriptome Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Biochem Biophys Res Commun 308:227-33. 2003
  4. ncbi request reprint Nemo-like kinase suppresses a wide range of transcription factors, including nuclear factor-kappaB
    Jun Yasuda
    Cancer Transcriptome Project, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 95:52-7. 2004
  5. ncbi request reprint Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice
    Tesshi Yamada
    Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Cancer Res 63:895-901. 2003
  6. pmc Traf2- and Nck-interacting kinase is essential for canonical Wnt signaling in Xenopus axis formation
    Reiko Satow
    Chemotherapy Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    J Biol Chem 285:26289-94. 2010
  7. pmc Survival prediction for pancreatic cancer patients receiving gemcitabine treatment
    Junichi Matsubara
    Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan mail
    Mol Cell Proteomics 9:695-704. 2010
  8. pmc Prolyl 4-hydroxylation of alpha-fibrinogen: a novel protein modification revealed by plasma proteomics
    Masaya Ono
    Chemotherapy Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Biol Chem 284:29041-9. 2009
  9. doi request reprint CXCL17 and ICAM2 are associated with a potential anti-tumor immune response in early intraepithelial stages of human pancreatic carcinogenesis
    Nobuyoshi Hiraoka
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 140:310-21. 2011
  10. doi request reprint Wnt signaling inside the nucleus
    Miki Shitashige
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuoh ku, Tokyo 104 0045, Japan
    Cancer Sci 99:631-7. 2008

Collaborators

Detail Information

Publications19

  1. doi request reprint Combined functional genome survey of therapeutic targets for clear cell carcinoma of the kidney
    Hideaki Ito
    Division of Chemotherapy and Clinical Research, National Cancer Centre Research Institute, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 41:847-53. 2011
    ..The aim of this study was to catalog potential therapeutic target molecules for renal cell carcinoma...
  2. ncbi request reprint Morphological and transcriptional responses of untransformed intestinal epithelial cells to an oncogenic beta-catenin protein
    Yasuyoshi Naishiro
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Oncogene 24:3141-53. 2005
    ..The IGFBP2 protein interacts with integrins. Disruption of the multigene network system regulating cell adhesion and cytoskeleton may be crucial in the initiation of colorectal carcinogenesis...
  3. ncbi request reprint Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells
    Jun Yasuda
    Cancer Transcriptome Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Biochem Biophys Res Commun 308:227-33. 2003
    ..Apoptosis induction by wild-type NLK was confirmed using TUNEL assays. Our results suggest that overexpression of NLK may have targets other than TCF for induction of apoptosis in human colon carcinoma cells...
  4. ncbi request reprint Nemo-like kinase suppresses a wide range of transcription factors, including nuclear factor-kappaB
    Jun Yasuda
    Cancer Transcriptome Project, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 95:52-7. 2004
    ..The extent of suppression by NLK was similar among the transcription factors tested (50-60% reduction). Our results suggest that NLK may suppress a wide range of gene expression, possibly through CBP...
  5. ncbi request reprint Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice
    Tesshi Yamada
    Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Cancer Res 63:895-901. 2003
    ..Inhibitors of P-glycoprotein may be included in a novel class of chemopreventive agents against colorectal carcinogenesis...
  6. pmc Traf2- and Nck-interacting kinase is essential for canonical Wnt signaling in Xenopus axis formation
    Reiko Satow
    Chemotherapy Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    J Biol Chem 285:26289-94. 2010
    ..These results demonstrate that XTNIK is an essential factor for the transcriptional activity of the beta-catenin-TCF complex and dorsal axis determination in Xenopus embryos...
  7. pmc Survival prediction for pancreatic cancer patients receiving gemcitabine treatment
    Junichi Matsubara
    Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan mail
    Mol Cell Proteomics 9:695-704. 2010
    ..Although an external validation study will be necessary, the current model may be useful for identifying patients unsuitable for the standardized therapy...
  8. pmc Prolyl 4-hydroxylation of alpha-fibrinogen: a novel protein modification revealed by plasma proteomics
    Masaya Ono
    Chemotherapy Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Biol Chem 284:29041-9. 2009
    ..Prolyl-hydroxylated alpha-fibrinogen is presumably controlled by multiple biological mechanisms, which remain to be clarified in future studies...
  9. doi request reprint CXCL17 and ICAM2 are associated with a potential anti-tumor immune response in early intraepithelial stages of human pancreatic carcinogenesis
    Nobuyoshi Hiraoka
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 140:310-21. 2011
    ..We investigated when and how the human anti-tumor immune reaction changes during pancreatic tumor development...
  10. doi request reprint Wnt signaling inside the nucleus
    Miki Shitashige
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuoh ku, Tokyo 104 0045, Japan
    Cancer Sci 99:631-7. 2008
    ..We also summarize current strategies in the development of drugs against Wnt signaling...
  11. ncbi request reprint Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma
    Yoshio Tomizawa
    Biology Division, Pathology Division, National Cancer Center Hospital, Tokyo 104 0045, Japan
    Clin Cancer Res 8:2362-8. 2002
    ..In this study, we investigated the pathogenetic and clinicopathological significances of RASSF1A methylation in the development and/or progression of lung adenocarcinoma...
  12. ncbi request reprint Plasma proteomics of pancreatic cancer patients by multi-dimensional liquid chromatography and two-dimensional difference gel electrophoresis (2D-DIGE): up-regulation of leucine-rich alpha-2-glycoprotein in pancreatic cancer
    Tatsuhiko Kakisaka
    Proteome Bioinformatics Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 852:257-67. 2007
    ..Our results demonstrate the application of a combination of multi-dimensional liquid chromatography with 2D-DIGE for plasma proteomics and suggest the clinical utility of LRG plasma level measurement...
  13. doi request reprint Functional genome screen for therapeutic targets of osteosarcoma
    Umio Yamaguchi
    Chemotherapy Division, National Cancer Centre Research Institute, Tokyo, Japan
    Cancer Sci 100:2268-74. 2009
    ..Recently, phase I clinical trials of PLK1 chemical inhibitors have been reported. Our results indicate that PLK1 is a promising molecular target for pharmacologic intervention in OS...
  14. ncbi request reprint Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling
    Masashi Idogawa
    Chemotherapy Division and ADP Ribosylation in Oncology Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Res 67:911-8. 2007
    ..Identification of the functional interaction of Ku70 as well as PARP-1 with the TCF-4 and beta-catenin transcriptional complex may provide insights into a novel linkage between DNA damage recognition/repair and Wnt signaling...
  15. doi request reprint Reduced argininosuccinate synthetase is a predictive biomarker for the development of pulmonary metastasis in patients with osteosarcoma
    Eisuke Kobayashi
    Chemotherapy Division, National Cancer Centre Research Institute, Chuo Ku, Tokyo, Japan
    Mol Cancer Ther 9:535-44. 2010
    ..Our data indicate that in patients with osteosarcoma, reduced expression of ASS is not only a novel predictive biomarker for the development of metastasis, but also a potential target for pharmacologic intervention...
  16. ncbi request reprint Mass spectrometry analysis of the native protein complex containing actinin-4 in prostate cancer cells
    Tomohiko Hara
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Tokyo 104 0045, Japan
    Mol Cell Proteomics 6:479-91. 2007
    ..The decreased expression of actinin-4 protein in prostate cancer cells may cause aberrations in the intracellular trafficking of various cell surface molecules and contribute to carcinogenesis...
  17. ncbi request reprint Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer
    Kazufumi Honda
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuoh ku, Tokyo 104 0045, Japan
    Gastroenterology 128:51-62. 2005
    ..However, its involvement in the mechanisms of cancer invasion and metastasis remains undetermined. The current study tested the role of actinin-4 in the motility and metastatic potential of colorectal cancer cells...
  18. ncbi request reprint Increased susceptibility of Sf1(+/-) mice to azoxymethane-induced colon tumorigenesis
    Miki Shitashige
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 98:1862-7. 2007
    ..The increased susceptibility of Sf1(+/-) mice to AOM-induced colon tumorigenesis indicates the crucial involvement of SF1 in the beta-catenin-mediated regulation of proliferation and differentiation of intestinal epithelial cells...
  19. doi request reprint Distinct gene expression-defined classes of gastrointestinal stromal tumor
    Umio Yamaguchi
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    J Clin Oncol 26:4100-8. 2008
    ..GISTs are considered to invariably arise through gain of function KIT or PDGFA mutation of the interstitial cells of Cajal (ICC). However, the genetic basis of the malignant progression of GISTs are poorly understood...