Masakazu Yamada

Summary

Affiliation: National Institute of Sensory Organs
Country: Japan

Publications

  1. pmc Impact of dry eye on work productivity
    Masakazu Yamada
    National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, Tokyo, Japan
    Clinicoecon Outcomes Res 4:307-12. 2012
  2. pmc Turnover rate of tear-film lipid layer determined by fluorophotometry
    H Mochizuki
    Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, 2 5 1 Higashigaoka, Meguro ku, Tokyo 152 8902, Japan
    Br J Ophthalmol 93:1535-8. 2009
  3. pmc Annual direct cost of dry eye in Japan
    Yoshinobu Mizuno
    Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
    Clin Ophthalmol 6:755-60. 2012
  4. pmc Evaluation of ocular surface glycocalyx using lectin-conjugated fluorescein
    Hiroshi Mochizuki
    Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
    Clin Ophthalmol 4:925-30. 2010
  5. pmc Decreased tear lipocalin concentration in patients with meibomian gland dysfunction
    M Yamada
    Department of Ophthalmology, Keigo University School of Medicine, Tokyo, Japan
    Br J Ophthalmol 89:803-5. 2005
  6. doi request reprint In vitro susceptibilities of bacterial isolates from conjunctival flora to gatifloxacin, levofloxacin, tosufloxacin, and moxifloxacin
    Masakazu Yamada
    Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, 2 5 1 Higashigaoka, Meguro ku, Tokyo 152 8902, Japan
    Eye Contact Lens 34:109-12. 2008
  7. ncbi request reprint Prevalence of visual impairment in the adult Japanese population by cause and severity and future projections
    Masakazu Yamada
    National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
    Ophthalmic Epidemiol 17:50-7. 2010
  8. ncbi request reprint A multicenter study on the health-related quality of life of cataract patients: baseline data
    Masakazu Yamada
    Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
    Jpn J Ophthalmol 53:470-6. 2009
  9. ncbi request reprint Corneal penetration of simultaneously applied topical levofloxacin, norfloxacin and lomefloxacin in human eyes
    Masakazu Yamada
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Acta Ophthalmol Scand 84:192-6. 2006
  10. ncbi request reprint Phospholipids and their degrading enzyme in the tears of soft contact lens wearers
    Masakazu Yamada
    Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, 2 5 1 Higashigaoka, Meguro ku, Tokyo 152 8902, Japan
    Cornea 25:S68-72. 2006

Detail Information

Publications51

  1. pmc Impact of dry eye on work productivity
    Masakazu Yamada
    National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, Tokyo, Japan
    Clinicoecon Outcomes Res 4:307-12. 2012
    ..The purpose of this study was to evaluate the impact of dry eye on work productivity of office workers, especially in terms of presenteeism...
  2. pmc Turnover rate of tear-film lipid layer determined by fluorophotometry
    H Mochizuki
    Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, 2 5 1 Higashigaoka, Meguro ku, Tokyo 152 8902, Japan
    Br J Ophthalmol 93:1535-8. 2009
    ..This study was performed to independently assess the turnover rates of aqueous and lipid layers of the tear film...
  3. pmc Annual direct cost of dry eye in Japan
    Yoshinobu Mizuno
    Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
    Clin Ophthalmol 6:755-60. 2012
    ..This study was performed to estimate the annual direct cost incurred by dry eye patients, which includes expenses for treatment and drugs, as well as the cost of punctal plugs...
  4. pmc Evaluation of ocular surface glycocalyx using lectin-conjugated fluorescein
    Hiroshi Mochizuki
    Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
    Clin Ophthalmol 4:925-30. 2010
    ..We tested a wheat germ agglutinin conjugate of fluorescein (F-WGA) as a marker to demonstrate ocular surface glycocalyx in vivo...
  5. pmc Decreased tear lipocalin concentration in patients with meibomian gland dysfunction
    M Yamada
    Department of Ophthalmology, Keigo University School of Medicine, Tokyo, Japan
    Br J Ophthalmol 89:803-5. 2005
    ..The level of TL in patients with meibomian gland dysfunction (MGD) was examined and these data were correlated with the severity of their clinical disorder...
  6. doi request reprint In vitro susceptibilities of bacterial isolates from conjunctival flora to gatifloxacin, levofloxacin, tosufloxacin, and moxifloxacin
    Masakazu Yamada
    Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, 2 5 1 Higashigaoka, Meguro ku, Tokyo 152 8902, Japan
    Eye Contact Lens 34:109-12. 2008
    ..To evaluate and compare the in vitro susceptibilities of various fluoroquinolones (i.e., gatifloxacin, levofloxacin, tosufloxacin, and moxifloxacin) against conjunctival bacterial flora...
  7. ncbi request reprint Prevalence of visual impairment in the adult Japanese population by cause and severity and future projections
    Masakazu Yamada
    National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
    Ophthalmic Epidemiol 17:50-7. 2010
    ....
  8. ncbi request reprint A multicenter study on the health-related quality of life of cataract patients: baseline data
    Masakazu Yamada
    Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
    Jpn J Ophthalmol 53:470-6. 2009
    ..This study examines the impact of cataracts on health-related quality of life (HR-QOL) and health events in the older population...
  9. ncbi request reprint Corneal penetration of simultaneously applied topical levofloxacin, norfloxacin and lomefloxacin in human eyes
    Masakazu Yamada
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Acta Ophthalmol Scand 84:192-6. 2006
    ..This study was performed to assess the corneal penetration of three topically applied fluoroquinolones (levofloxacin, norfloxacin and lomefloxacin) in corneal buttons obtained from patients undergoing penetrating keratoplasty...
  10. ncbi request reprint Phospholipids and their degrading enzyme in the tears of soft contact lens wearers
    Masakazu Yamada
    Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, 2 5 1 Higashigaoka, Meguro ku, Tokyo 152 8902, Japan
    Cornea 25:S68-72. 2006
    ..We assayed levels of phospholipids and their degrading enzyme secretory phospholipase A2 (sPLA2) both in tears and deposited on contact lenses composed of 2 hydrophilic materials after 1 day of routine use...
  11. pmc Mutations in the quinolone resistance determining region in Staphylococcus epidermidis recovered from conjunctiva and their association with susceptibility to various fluoroquinolones
    M Yamada
    Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, 2 5 1 Higashigaoka, Meguro ku, Tokyo 152 8902, Japan
    Br J Ophthalmol 92:848-51. 2008
    ..The prevalence of mutations in the quinolone resistance determining region (QRDR) area in S epidermidis isolated from the ocular surface and its association with fluoroquinolone resistance has not been fully elucidated...
  12. ncbi request reprint New grading system for the evaluation of chronic ocular manifestations in patients with Stevens-Johnson syndrome
    Chie Sotozono
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Ophthalmology 114:1294-302. 2007
    ..To evaluate and grade the extent and severity of chronic ocular manifestations in Stevens-Johnson syndrome (SJS)...
  13. doi request reprint Association between clinical diagnostic tests and health-related quality of life surveys in patients with dry eye syndrome
    Yoshinobu Mizuno
    Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, Meguro ku, Tokyo, Japan
    Jpn J Ophthalmol 54:259-65. 2010
    ..This study was performed to assess the impact of dry eye on patients' quality of life (QOL) and to analyze the association between subjective symptoms and ocular surface findings of dry eye...
  14. ncbi request reprint Substance P in human tears
    Masakazu Yamada
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Cornea 22:S48-54. 2003
    ..To determine the levels and biochemical characteristics of substance P-like immunoreactivity (SPLI) in human tears and ascertain whether substance P (SP) concentrations in tears reflect the condition of the ocular surface...
  15. ncbi request reprint Aqueous humor levels of topically applied levofloxacin, norfloxacin, and lomefloxacin in the same human eyes
    Masakazu Yamada
    Departments of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    J Cataract Refract Surg 29:1771-5. 2003
    ..To assess the relative penetration of topical eyedrops of 3 fluoroquinolones into the aqueous humor in human eyes...
  16. doi request reprint Comparison of corneal and aqueous humor penetration of moxifloxacin, gatifloxacin and levofloxacin during keratoplasty
    Masahiko Fukuda
    Department of Ophthalmology, Kinki University Faculty of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka, 589 8511, Japan
    Adv Ther 29:339-49. 2012
    ..5% moxifloxacin, 0.3% gatifloxacin, and 0.5% levofloxacin in the corneal tissue and aqueous humor after topical instillation in patients undergoing penetrating keratoplasty...
  17. ncbi request reprint Role of insulin in regulation of Na+-/K+-dependent ATPase activity and pump function in corneal endothelial cells
    Shin Hatou
    Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
    Invest Ophthalmol Vis Sci 51:3935-42. 2010
    ..The role of insulin in the regulation of Na,K-ATPase activity and pump function in corneal endothelial cells was investigated...
  18. ncbi request reprint The relation between visual performance and clinical ocular manifestations in Stevens-Johnson syndrome
    Minako Kaido
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Am J Ophthalmol 154:499-511.e1. 2012
    ..To investigate the relation between visual function, clinical findings, and visual symptoms in Stevens-Johnson syndrome (SJS) and to compare the results with Sjögren syndrome (SS) patients and normal subjects...
  19. doi request reprint The effects of dexamethasone on the Na,K-ATPase activity and pump function of corneal endothelial cells
    Shin Hatou
    Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
    Curr Eye Res 34:347-54. 2009
    ..We investigated the possible role of dexamethasone in the regulation of Na,K-ATPase activity and pump function in corneal endothelial cells...
  20. doi request reprint Deposition of lipid, protein, and secretory phospholipase A2 on hydrophilic contact lenses
    Hiroshi Mochizuki
    Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
    Eye Contact Lens 34:46-9. 2008
    ..This study was performed to determine the levels of sPLA2 from the deposition on two different frequent-replacement contact lens materials...
  21. ncbi request reprint Substance P and its metabolites in normal human tears
    Masakazu Yamada
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 43:2622-5. 2002
    ..To determine amounts and biochemical characteristics of substance P-like immunoreactivity (SPLI) in tears of normal human subjects...
  22. ncbi request reprint Increasing ofloxacin resistance of bacterial flora from conjunctival sac of preoperative ophthalmic patients in Japan
    Naoyuki Kurokawa
    Department of Ophthalmology, National Tokyo Medical Center, The Policy Based Medical Services Network Study Group for Sensory Organ, Tokyo, Japan
    Jpn J Ophthalmol 46:586-9. 2002
    ..To examine the in vitro resistance to ofloxacin of preoperative bacterial isolates from the conjunctival sac of Japanese patients...
  23. doi request reprint The disease burden of keratoconus in patients' lives: comparisons to a Japanese normative sample
    Yukako Tatematsu-Ogawa
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Eye Contact Lens 34:13-6. 2008
    ..The objective of this study was to evaluate vision-related quality of life (VR-QOL) in patients with keratoconus by using the Japanese version of the National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25)...
  24. ncbi request reprint Quantitative evaluation of tear meniscus height from fluorescein photographs
    Masataka Kawai
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Cornea 26:403-6. 2007
    ..To describe a method of quantifying the tear meniscus height (TMH) and using these values to diagnose patients with dry eye...
  25. doi request reprint Clinical features of anterior segment dysgenesis associated with congenital corneal opacities
    Chika Shigeyasu
    Division for Vision Research, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, Megurao ku, Tokyo, Japan
    Cornea 31:293-8. 2012
    ..Anterior segment dysgenesis is one of the main causes of congenital corneal opacities. In this study, we investigated the clinical features and visual outcomes of patients with anterior segment dysgenesis in a large number of cases...
  26. doi request reprint Evaluation of the frequency of ophthalmic solution application: washout effects of topical saline application on tear components
    Chika Shigeyasu
    National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, Meguro ku, Tokyo, Japan
    Curr Eye Res 38:722-8. 2013
    ..To determine and compare the effects of single and frequent topical applications of saline solution on tear protein concentration in clinically normal subjects...
  27. ncbi request reprint Aqueous humor levels of topically applied levofloxacin in human eyes
    Masakazu Yamada
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Curr Eye Res 24:403-6. 2002
    ..To evaluate transcorneal penetration of topically applied 0.5% levofloxacin into the aqueous humor in human eyes...
  28. pmc Prevalence of pterygium in a population in Northern Japan: the Locomotive Syndrome and Health Outcome in Aizu Cohort Study
    Takatoshi Tano
    Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
    Acta Ophthalmol 91:e232-6. 2013
    ..The aim of the study was to determine the prevalence and risk factors for pterygium in a population aged 40-74 years in Fukushima Prefecture, Japan...
  29. doi request reprint Quality of life and cost-utility assessment after strabismus surgery in adults
    Keiko Fujiike
    Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, 2 5 1 Higashigaoka, Meguro ku, Tokyo, 152 8902, Japan
    Jpn J Ophthalmol 55:268-76. 2011
    ..In this study, we assessed quality of life and utility in adult patients who had undergone strabismus surgery, and we modeled the cost of providing this intervention in order to calculate the cost-utility of strabismus surgery in adults...
  30. ncbi request reprint Functional visual acuity in Stevens-Johnson syndrome
    Minako Kaido
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Am J Ophthalmol 142:917-22. 2006
    ..To evaluate the correlation of functional visual acuity (FVA) measurement with ocular surface findings in patients with Stevens-Johnson syndrome (SJS)...
  31. doi request reprint Role of protein kinase C in regulation of Na+- and K +-dependent ATPase activity and pump function in corneal endothelial cells
    Shin Hatou
    Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
    Jpn J Ophthalmol 53:235-42. 2009
    ..We investigated the possible role of protein kinase C (PKC) in regulation of Na,K-ATPase activity and pump function in corneal endothelial cells...
  32. ncbi request reprint Topical diclofenac sodium decreases the substance P content of tears
    Masakazu Yamada
    Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160, Japan
    Arch Ophthalmol 120:51-4. 2002
    ..To explore the mechanism by which diclofenac sodium eyedrops exert an adverse effect on the cornea...
  33. ncbi request reprint Keratomycosis caused by Aspergillus viridinutans: an Aspergillus fumigatus-resembling mold presenting distinct clinical and antifungal susceptibility patterns
    Chika Shigeyasu
    Division for Vision Research, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, Tokyo
    Med Mycol 50:525-8. 2012
    ..viridinutans. These species may show clinical manifestations distinct from those of A. fumigatus, including clinical resistance to amphotericin B and voriconazole and relatively low susceptibility to other antifungal agents...
  34. pmc Presumed stromal graft rejection after automated lamellar therapeutic keratoplasty: case report
    Motoko Kawashima
    Department of Ophthalmology, Tokyo Dental College, Chiba, Japan
    J Med Case Reports 1:10. 2007
    ..To describe the development of presumed immune-mediated stromal rejection after automated lamellar therapeutic keratoplasty (ALTK) and its reversal after initiation of intensive topical corticosteroid therapy...
  35. ncbi request reprint Evaluation of corneal endothelial pump function with a cold stress test
    Reiko Arita
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Cornea 24:571-5. 2005
    ..This study was designed to evaluate corneal endothelial pump function with a cold-stress test...
  36. ncbi request reprint Secondary amyloidosis in a corneal graft
    Masakazu Yamada
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Jpn J Ophthalmol 46:305-7. 2002
    ..To describe a case of secondary amyloidosis that occurred in a corneal graft...
  37. ncbi request reprint [Six cases of late-onset lattice corneal dystrophy associated with gene mutations induced by the transforming growth factor-beta]
    Motoko Kawashima
    Department of Ophthalmology, Keio University School of Medicine, Japan
    Nihon Ganka Gakkai Zasshi 109:93-100. 2005
    ..To investigate mutations in the transforming growth factor beta induced (TGFBI) gene and clinical features in 6 Japanese patients who were clinically diagnosed as having late-onset lattice corneal dystrophy (LCD)...
  38. ncbi request reprint Vitreous concentrations of triamcinolone acetonide in human eyes after intravitreal or subtenon injection
    Makoto Inoue
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Am J Ophthalmol 138:1046-8. 2004
    ..To compare vitreous concentrations of triamcinolone acetonide (TA) achieved by prior therapeutic intravitreal and subtenon injections...
  39. ncbi request reprint Periductal area as the primary site for T-cell activation in lacrimal gland chronic graft-versus-host disease
    Yoko Ogawa
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 44:1888-96. 2003
    ..To examine immune processes in the lacrimal gland of patients with chronic graft-versus-host disease (cGVHD) by evaluating the expression of surface molecules associated with T-cell activation...
  40. pmc Establishment of functioning human corneal endothelial cell line with high growth potential
    Tadashi Yokoi
    Department of Ophthalomology, National Center for Child Health and Development, Tokyo, Japan
    PLoS ONE 7:e29677. 2012
    ..This study shows that HCEC cell cycle activation can be achieved by inhibiting CKIs even while maintaining critical pump function and morphology...
  41. ncbi request reprint Fluorophotometric measurement of the buffering action of human tears in vivo
    M Yamada
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Curr Eye Res 17:1005-9. 1998
    ..The buffering action of human tears is thought to be important to keep its pH constant. We measured the change in pH in the precorneal tear film in vivo when the acidic solution is challenged, using a fluorophotometric technique...
  42. ncbi request reprint Fluorophotometric measurement of the precorneal residence time of topically applied hyaluronic acid
    H Mochizuki
    Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, 2 5 1 Higashigaoka, Meguro, Tokyo 152 8902, Japan
    Br J Ophthalmol 92:108-11. 2008
    ..This study was performed to separately assess the aqueous flow applied with hyaluronic acid, and the behaviour of hyaluronic acid itself on the ocular surface...
  43. ncbi request reprint Decreased substance P concentrations in tears from patients with corneal hypesthesia
    M Yamada
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Am J Ophthalmol 129:671-2. 2000
    ..To determine whether substance P concentrations in tears reflect corneal hypesthesia...
  44. ncbi request reprint Linkage disequilibrium and association with methamphetamine dependence/psychosis of mu-opioid receptor gene polymorphisms
    S Ide
    Division of Psychobiology, Tokyo Institute of Psychiatry, Tokyo, Japan
    Pharmacogenomics J 6:179-88. 2006
    ..There was also a significant association between IVS2+G691C and patients with transient psychosis. These results suggest that the OPRM1 gene variations may be a factor in development and prognosis of MAP psychosis...
  45. ncbi request reprint Missense mutations in the PAX6 gene in aniridia
    N Azuma
    Department of Ophthalmology, National Children s Hospital, Tokyo, Japan
    Invest Ophthalmol Vis Sci 39:2524-8. 1998
    ..Only two missense mutations have been detected in aniridia pedigrees, each of which occurs in its paired domain or homeodomain. In this study, four novel missense mutations were found in three aniridia pedigrees...
  46. pmc Missense mutation in the alternative splice region of the PAX6 gene in eye anomalies
    N Azuma
    Department of Ophthalmology, National Children s Hospital, Tokyo 154 8509, Japan
    Am J Hum Genet 65:656-63. 1999
    ..Functional analyses demonstrated that the V54D mutation slightly increased NTS binding and decreased CTS transactivation activity to almost half...
  47. ncbi request reprint Successful treatment of dry eye in two patients with chronic graft-versus-host disease with systemic administration of FK506 and corticosteroids
    Y Ogawa
    Department of Ophthalmology, Division of Hematology, The Department of Medicine, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
    Cornea 20:430-4. 2001
    ..We present two cases of severe dry eye in patients with chronic graft-versus-host disease (CGVHD) after hematopoietic stem cell transplantation (SCT) who were successfully treated by the systemic administration of FK506 and corticosteroids...
  48. ncbi request reprint Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family
    M U
    Department of Genetics, National Children s Medical Research Center, 3 35 31 Taishido, Setagayaku, 154 8509, Tokyo, Japan
    FEBS Lett 509:135-41. 2001
    ....
  49. ncbi request reprint Autologous serum eye drops for the treatment of severe dry eye in patients with chronic graft-versus-host disease
    Y Ogawa
    Department of Ophthalmology, School of Medicine, Keio University, Tokyo, Japan
    Bone Marrow Transplant 31:579-83. 2003
    ....
  50. ncbi request reprint Missense mutation at the C terminus of the PAX6 gene in ocular anterior segment anomalies
    N Azuma
    Department of Ophthalmology, National Children s Hospital, Tokyo, Japan
    Invest Ophthalmol Vis Sci 39:828-30. 1998
    ..To report a rare case of ocular anterior segment anomalies including uveal ectropion of the iris, invasion of the conjunctival epithelia into the cornea, and posterior embryotoxon with a missense mutation of the PAX6 gene...
  51. ncbi request reprint Lattice corneal dystrophy type III in patients with a homozygous L527R mutation in the TGFBI gene
    Tomoyo Funayama
    Jpn J Ophthalmol 50:62-4. 2006