B Wang

Summary

Affiliation: National Institute of Radiological Sciences
Country: Japan

Publications

  1. doi request reprint Total-body low-dose irradiation of mice induces neither learning disability and memory impairment in Morris water maze test nor Alzheimer's disease-like pathogensis in the brain
    Bing Wang
    National Institute of Radiological Sciences, Anagawa 4 9 1, Inage Ku, Chiba 263 8555, Japan
    J Radiat Res 55:i20-i21. 2014
  2. pmc Total body 100-mGy X-irradiation does not induce Alzheimer's disease-like pathogenesis or memory impairment in mice
    Bing Wang
    Research Center for Radiation Protection, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba 263 8555, Japan
    J Radiat Res 55:84-96. 2014
  3. pmc Sodium orthovanadate (vanadate), a potent mitigator of radiation-induced damage to the hematopoietic system in mice
    Bing Wang
    Radiation Risk Reduction Research Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Anagawa 4 9 1, Inage Ku, Chiba 263 8555, Japan
    J Radiat Res 54:620-9. 2013
  4. pmc Relieved residual damage in the hematopoietic system of mice rescued by radiation-induced adaptive response (Yonezawa Effect)
    Bing Wang
    Radiation Risk Reduction Research Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Anagawa 4 9 1, Inage Ku, Chiba 263 8555, Japan
    J Radiat Res 54:45-51. 2013
  5. doi request reprint X-ray-induced radioresistance against high-LET radiations from accelerated heavy ions in mice
    Bing Wang
    Research Center for Radiation Protection, National Institute of Radiological Sciences, Anagawa 4 9 1, Inage Ku, Chiba 263 8555, Japan
    Radiat Res 174:532-6. 2010
  6. ncbi request reprint Adaptive response in embryogenesis: V. Existence of two efficient dose-rate ranges for 0.3 Gy of priming irradiation to adapt mouse fetuses
    Bing Wang
    Radiation Hazards Research Group, Radiation Safety Research Center, National Institute of Radiological Sciences, Anagawa 4 9 1, Inage Ku, Chiba 263 8555, Japan
    Radiat Res 161:264-72. 2004
  7. ncbi request reprint Adaptive response in embryogenesis: IV. Protective and detrimental bystander effects induced by X radiation in cultured limb bud cells of fetal mice
    Bing Wang
    Radiation Hazards Research Group, Radiation Safety Research Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Radiat Res 161:9-16. 2004
  8. ncbi request reprint Involvement of p53-dependent apoptosis in radiation teratogenesis and in the radioadaptive response in the late organogenesis of mice
    B Wang
    Division of Radiobiology and Biodosimetry, National Institute of Radiological Sciences, Anagawa 4 9 1, Inage Ku, Chiba 263 8555, Japan
    J Radiat Res 42:1-10. 2001
  9. ncbi request reprint Rescue of lethally irradiated mice from hematopoietic death by pre-exposure to 0.5 Gy X rays without recovery from peripheral blood cell depletion and its modification by OK432
    M Nose
    Radiation Hazards Research Group, National Institute of Radiological Sciences, Chiba, 263-8555, Japan
    Radiat Res 156:195-204. 2001
  10. doi request reprint Adaptive response in embryogenesis: vi. Comparative microarray analysis of gene expressions in mouse fetuses
    G Vares
    National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba, Japan
    Int J Radiat Biol 85:70-86. 2009

Collaborators

Detail Information

Publications34

  1. doi request reprint Total-body low-dose irradiation of mice induces neither learning disability and memory impairment in Morris water maze test nor Alzheimer's disease-like pathogensis in the brain
    Bing Wang
    National Institute of Radiological Sciences, Anagawa 4 9 1, Inage Ku, Chiba 263 8555, Japan
    J Radiat Res 55:i20-i21. 2014
    ..10 Gy could hardly induce significant early or late transcriptional alterations in most of the AD-related genes in the hippocampus, learning disability and memory impairment, and AD-like pathological change in the brain in mice [ 3]. ..
  2. pmc Total body 100-mGy X-irradiation does not induce Alzheimer's disease-like pathogenesis or memory impairment in mice
    Bing Wang
    Research Center for Radiation Protection, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba 263 8555, Japan
    J Radiat Res 55:84-96. 2014
    ..TBI induced early or late transcriptional alteration in only a few AD-related genes but did not significantly affect spatial learning, memory or AD-like pathological change in mice. ..
  3. pmc Sodium orthovanadate (vanadate), a potent mitigator of radiation-induced damage to the hematopoietic system in mice
    Bing Wang
    Radiation Risk Reduction Research Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Anagawa 4 9 1, Inage Ku, Chiba 263 8555, Japan
    J Radiat Res 54:620-9. 2013
    ....
  4. pmc Relieved residual damage in the hematopoietic system of mice rescued by radiation-induced adaptive response (Yonezawa Effect)
    Bing Wang
    Radiation Risk Reduction Research Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Anagawa 4 9 1, Inage Ku, Chiba 263 8555, Japan
    J Radiat Res 54:45-51. 2013
    ..These findings provide new knowledge of the characterization of the Yonezawa Effect by providing new insight into the mechanistic study of AR in vivo...
  5. doi request reprint X-ray-induced radioresistance against high-LET radiations from accelerated heavy ions in mice
    Bing Wang
    Research Center for Radiation Protection, National Institute of Radiological Sciences, Anagawa 4 9 1, Inage Ku, Chiba 263 8555, Japan
    Radiat Res 174:532-6. 2010
    ..These findings would provide new insight into the radiation-induced adaptive response in vivo...
  6. ncbi request reprint Adaptive response in embryogenesis: V. Existence of two efficient dose-rate ranges for 0.3 Gy of priming irradiation to adapt mouse fetuses
    Bing Wang
    Radiation Hazards Research Group, Radiation Safety Research Center, National Institute of Radiological Sciences, Anagawa 4 9 1, Inage Ku, Chiba 263 8555, Japan
    Radiat Res 161:264-72. 2004
    ..This paper provides the first evidence for the existence of two dose-rate ranges for the same dose of priming radiation to successfully induce an adaptive response in mouse fetuses...
  7. ncbi request reprint Adaptive response in embryogenesis: IV. Protective and detrimental bystander effects induced by X radiation in cultured limb bud cells of fetal mice
    Bing Wang
    Radiation Hazards Research Group, Radiation Safety Research Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Radiat Res 161:9-16. 2004
    ..Gap junction-mediated intercellular communication was suggested to be involved in the induction of the bystander effect...
  8. ncbi request reprint Involvement of p53-dependent apoptosis in radiation teratogenesis and in the radioadaptive response in the late organogenesis of mice
    B Wang
    Division of Radiobiology and Biodosimetry, National Institute of Radiological Sciences, Anagawa 4 9 1, Inage Ku, Chiba 263 8555, Japan
    J Radiat Res 42:1-10. 2001
    ..p53-heterozygous embryos did not show the radioadaptive response, indicating the involvement of p53 in the radioadaptive response in embryogenesis...
  9. ncbi request reprint Rescue of lethally irradiated mice from hematopoietic death by pre-exposure to 0.5 Gy X rays without recovery from peripheral blood cell depletion and its modification by OK432
    M Nose
    Radiation Hazards Research Group, National Institute of Radiological Sciences, Chiba, 263-8555, Japan
    Radiat Res 156:195-204. 2001
    ..These results suggest that radioresistance induced by pre-exposure to 0.5 Gy X rays is not stable, but rather varies with the physiological conditions, and can be modulated by factors such as OK432...
  10. doi request reprint Adaptive response in embryogenesis: vi. Comparative microarray analysis of gene expressions in mouse fetuses
    G Vares
    National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba, Japan
    Int J Radiat Biol 85:70-86. 2009
    ..We previously demonstrated the existence of AR in mice during late organogenesis. In this study, we investigated molecular mechanisms underlying AR in this model...
  11. ncbi request reprint Radio-sensitive murine thymoma cell line 3SB: characterization of its apoptosis-resistant variants induced by repeated X-irradiation
    H Hama-Inaba
    Bioregulation Research Group, National Institute of Radiological Sciences, Chiba, Japan
    Mutat Res 403:85-94. 1998
    ..Present result suggests that the induction of X-ray resistance by repeated X-irradiation might be achieved, at least partly, by the enhanced resistance to the ceramide-mediated apoptosis...
  12. ncbi request reprint Fas-independent apoptosis induced by UVC in p53-mutated human epithelial tumor A431 cells through activation of caspase-8 and JNK/SAPK
    H Hama-Inaba
    Radiation Hazards Research Group, National Institute of Radiological Sciences, Chiba, Japan
    J Radiat Res (Tokyo) 42:201-15. 2001
    ..prior to apoptotic chromatin condensation. Our data suggest that the activation of caspase-8 occurs independent of Fas upregulation, and that JNK/ SAPK contributes to UVC-induced apoptosis in human epithelial A431 cells...
  13. ncbi request reprint Adaptive response in embryogenesis. III. Relationship to radiation-induced apoptosis and Trp53 gene status
    B Wang
    Division of Radiobiology and Biodosimetry, National Institute of Radiological Sciences, Anagawa 4 9 1, Inage Ku, Chiba 263 8555, Japan
    Radiat Res 154:277-82. 2000
    ..These findings indicate that induction of a radioadaptive response in embryogenesis is related to Trp53 gene status and the occurrence of radiation-induced apoptosis...
  14. ncbi request reprint A mouse carrying genetic defect in the choice between T and B lymphocytes
    Y Tokoro
    Department of Immunology, University of Tsukuba, Tennodai, Japan
    J Immunol 161:4591-8. 1998
    ..Thus, tg epsilon26 mice provide a novel mouse model in that lineage choice between T and B lymphocytes is genetically defective...
  15. ncbi request reprint Gold sodium thiomalate suppresses the differentiation and function of human dendritic cells from peripheral blood monocytes
    Z Y Wang
    Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
    Clin Exp Rheumatol 20:683-8. 2002
    ..To clarify the mechanism of therapeutic effects of GST on RA, we investigated if GST affects the differentiation of dendritic cells (DC), which are thought to play a pivotal role in RA pathogenesis...
  16. ncbi request reprint [Substituting esophagus with colon in the treatment of hypopharyngeal and esophageal disease]
    B Wang
    Department of Otolaryngology, First Clinical Hospital of Shanxi Medical University, Taiyuan 030001
    Lin Chuang Er Bi Yan Hou Ke Za Zhi 15:389-90. 2001
    ..5% with cervical esophagus cancer, respectively. CONCLUSION: Substituting esophagus with colon is in conformity with physical demand, can reduce complication and improve life quality...
  17. ncbi request reprint Alternative splicing of human NrCAM in neural and nonneural tissues
    B Wang
    University of Cambridge Department of Medicine, Addenbrooke s Hospital, United Kingdom
    Mol Cell Neurosci 10:287-95. 1998
    ....
  18. pmc Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice
    J Y Chan
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
    EMBO J 17:1779-87. 1998
    ..To determine the function of Nrf-1, targeted disruption of the Nrf-1 gene was carried out. Homozygous Nrf-1 mutant mice are anemic due to a non-cell autonomous defect in definitive erythropoiesis and die in utero...
  19. ncbi request reprint Pregnancy-associated uterine granulated metrial gland cells in mutant and transgenic mice
    M J Guimond
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Canada
    Am J Reprod Immunol 35:501-9. 1996
    ..Pregnancy-specific functions have been postulated for GMG cells, but no successful depletion of these cells has been achieved that would permit assessment of any critical roles that might influence gestational outcome...
  20. pmc Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae
    S F Law
    Division of Basic Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Biol 16:3327-37. 1996
    ..We anticipate that HEF1 may prove to be an important linking element between extracellular signalling and regulation of the cytoskeleton...
  21. pmc Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine
    C P Liu
    Division of Immunology, Beth Israel Hospital Harvard Medical School, Boston, MA 02215
    EMBO J 12:4863-75. 1993
    ..In comparison to thymus-derived peripheral T cells in the spleen and lymph nodes, the preferential expression of normal levels of TCR/CD3 in intestinal IELs suggested they mature via an independent extrathymic pathway...
  22. ncbi request reprint Over-expression of CD3 epsilon transgenes blocks T lymphocyte development
    B Wang
    Division of Immunology, Beth Israel Hospital, Harvard Medical School, Boston, MA 02115, USA
    Int Immunol 7:435-48. 1995
    ..We therefore speculate that in the homozygous tg epsilon 26 animals the arrest in T cell development was caused by excessive signal transduction events rather than by a toxic effect of the transgenic protein...
  23. ncbi request reprint Inhibitory effect of recombinant TGFalpha-PE40 on neointimal proliferation after arterial balloon injury
    B Wang
    Department of Cardiology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
    Acta Pharmacol Sin 22:15-20. 2001
    ..01). CONCLUSION: Recombinant TP40 greatly inhibited neointimal proliferation after arterial balloon injury...
  24. ncbi request reprint MCF-10A-NeoST: a new cell system for studying cell-ECM and cell-cell interactions in breast cancer
    N D Zantek
    Department of Basic Medical Sciences, Purdue University, West Lafayette, IN 47905, USA
    Clin Cancer Res 7:3640-8. 2001
    ..CONCLUSIONS: MCF-10A and these new derivatives provide a genetically matched model to study defects in cell adhesion and signaling that are relevant to cellular behaviors that often typify aggressive breast cancer cells...
  25. ncbi request reprint T lymphocyte development in the absence of CD3 epsilon or CD3 gamma delta epsilon zeta
    B Wang
    Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 162:88-94. 1999
    ..Moreover, CD3 proteins are dispensable for NK cell development...
  26. ncbi request reprint Prolonged eosinophil accumulation in allergic lung interstitium of ICAM-2 deficient mice results in extended hyperresponsiveness
    N Gerwin
    Millennium BioTherapeutics, Cambridge, Massachusetts 02139, USA
    Immunity 10:9-19. 1999
    ..ICAM-2 is not essential for lymphocyte homing or the development of leukocytes, with the exception of megakaryocyte progenitors, which are significantly reduced...
  27. ncbi request reprint Expression of CD1d2 on thymocytes is not sufficient for the development of NK T cells in CD1d1-deficient mice
    Y H Chen
    Gwen Knapp Center for Lupus and Immunology Research, Committee on Immunology, Department of Pathology, University of Chicago, IL 60637, USA
    J Immunol 162:4560-6. 1999
    ..Given the structural similarities, it is possible that the low levels of surface expression and limited tissue distribution of CD1d2 may prevent it from functioning in the selection and expansion of NK T cells...
  28. ncbi request reprint Comparative contribution of CD1 on the development of CD4+ and CD8+ T cell compartments
    B Wang
    Gwen Knapp Center for Lupus, Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 164:739-45. 2000
    ..Our data suggest that, unlike other MHC class I molecules, CD1 does not contribute in a major way to the development of CD8+ T cells...
  29. ncbi request reprint Cutting edge: the Ets1 transcription factor is required for the development of NK T cells in mice
    T L Walunas
    Department of Medicine and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL 60637, USA
    J Immunol 164:2857-60. 2000
    ..We conclude that Ets1 defines a novel transcriptional regulatory pathway that is required for the development of both the NK and NK T cell lineages...
  30. ncbi request reprint Intact nitric oxide synthase II gene is required for interferon-beta-mediated suppression of growth and metastasis of pancreatic adenocarcinoma
    B Wang
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 61:71-5. 2001
    ..These data suggested that IFN-beta secreted from tumor cells stimulates NO production by host cells and suppresses tumor growth and metastasis...
  31. ncbi request reprint Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway
    H Miao
    Rammelkamp Center for Research, MetroHealth Campus, Case Western Reserve University School of Medicine, 2500 MetroHealth Drive, Cleveland, Ohio 44109 USA
    Nat Cell Biol 3:527-30. 2001
    ..Our results identify EphA kinases as negative regulators of the Ras/MAPK pathway that exert anti-mitogenic functions in a cell-type-specific manner...
  32. ncbi request reprint p202, an interferon-inducible protein, mediates multiple antitumor activities in human pancreatic cancer xenograft models
    Y Wen
    Department of Molecular and Cellular Oncology, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 61:7142-7. 2001
    ..Together, our results strongly suggest that p202 expression mediates multiple antitumor activities against pancreatic cancer and may provide a scientific basis for developing a p202-based gene therapy in pancreatic cancer treatment...
  33. ncbi request reprint Genetic disruption of host interferon-gamma drastically enhances the metastasis of pancreatic adenocarcinoma through impaired expression of inducible nitric oxide synthase
    B Wang
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, TX 77030, USA
    Oncogene 20:6930-7. 2001
    ..These data suggested that the tumor cells stimulated IFN-gamma secretion from host cells, which in turn stimulated NO production by host cells and suppressed tumor growth and metastasis...
  34. ncbi request reprint Regulation of thymocyte development through CD3: functional dissociation between p56lck and CD3 sigma in early thymic selection
    C N Levelt
    Max Planck Institut für Immunobiologie, Freiburg, Federal Republic of Germany
    Immunity 3:215-22. 1995
    ..Thus, CD3 sigma and p56lck are functionally not tightly associated and their deficiencies cause distinct developmental defects...