Hideki Ueno

Summary

Affiliation: National Defense Medical College
Country: Japan

Publications

  1. doi request reprint Histogenesis and prognostic value of myenteric spread in colorectal cancer: a Japanese multi-institutional study
    Hideki Ueno
    Department of Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama, 359 8513, Japan
    J Gastroenterol 49:400-7. 2014
  2. doi request reprint Peritumoral deposits as an adverse prognostic indicator of colorectal cancer
    Hideki Ueno
    Department of Surgery, National Defense Medical College, 3 2, Namiki, Tokorozawa, Saitama 359 8513, Japan Electronic address
    Am J Surg 207:70-7. 2014
  3. pmc Study protocol of the SACURA trial: a randomized phase III trial of efficacy and safety of UFT as adjuvant chemotherapy for stage II colon cancer
    Megumi Ishiguro
    Department of Surgical Oncology, Tokyo Medical and Dental University, Graduate School, 1 5 45 Yushima, Tokyo 113 8519, Japan
    BMC Cancer 12:281. 2012
  4. doi request reprint Objective criteria for crohn-like lymphoid reaction in colorectal cancer
    Hideki Ueno
    Dept of Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Am J Clin Pathol 139:434-41. 2013
  5. doi request reprint Optimal colorectal cancer staging criteria in TNM classification
    Hideki Ueno
    National Defense Medical College, Tokorozawa, Japan
    J Clin Oncol 30:1519-26. 2012
  6. doi request reprint Multicenter study for optimal categorization of extramural tumor deposits for colorectal cancer staging
    Hideki Ueno
    Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
    Ann Surg 255:739-46. 2012
  7. doi request reprint New criteria for histologic grading of colorectal cancer
    Hideki Ueno
    Department of Surgery, National Defense Medical College Hospital, Japan
    Am J Surg Pathol 36:193-201. 2012
  8. pmc Potential prognostic benefit of lateral pelvic node dissection for rectal cancer located below the peritoneal reflection
    Hideki Ueno
    Department of Surgery I, National Defense Medical College, Tokorozawa, Saitama, Japan
    Ann Surg 245:80-7. 2007
  9. doi request reprint Growth pattern in the muscular layer reflects the biological behaviour of colorectal cancer
    H Ueno
    Department of Surgery, National Defense Medical College, 3 2, Namiki, Tokorozawa, Saitama 359 8513, Japan
    Colorectal Dis 11:951-9. 2009
  10. doi request reprint Actual status of distribution and prognostic impact of extramural discontinuous cancer spread in colorectal cancer
    Hideki Ueno
    Department of Surgery, National Defense Medical College, 3 2, Namiki, Tokorozawa, Saitama 359 8513, Japan
    J Clin Oncol 29:2550-6. 2011

Detail Information

Publications76

  1. doi request reprint Histogenesis and prognostic value of myenteric spread in colorectal cancer: a Japanese multi-institutional study
    Hideki Ueno
    Department of Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama, 359 8513, Japan
    J Gastroenterol 49:400-7. 2014
    ..The histogenesis of the pattern of cancer spread along Auerbach's plexus (myenteric spread: MS) remains unclear and its prognostic value in colorectal cancer (CRC) has not been thoroughly investigated...
  2. doi request reprint Peritumoral deposits as an adverse prognostic indicator of colorectal cancer
    Hideki Ueno
    Department of Surgery, National Defense Medical College, 3 2, Namiki, Tokorozawa, Saitama 359 8513, Japan Electronic address
    Am J Surg 207:70-7. 2014
    ..The aim of this study was to determine the prognostic value of peritumoral deposits (PTDs) in colorectal cancer (CRC)...
  3. pmc Study protocol of the SACURA trial: a randomized phase III trial of efficacy and safety of UFT as adjuvant chemotherapy for stage II colon cancer
    Megumi Ishiguro
    Department of Surgical Oncology, Tokyo Medical and Dental University, Graduate School, 1 5 45 Yushima, Tokyo 113 8519, Japan
    BMC Cancer 12:281. 2012
    ..The major Western guidelines recommend adjuvant chemotherapy for "high-risk stage II" cancer, but this is not clearly defined and the efficacy has not been confirmed...
  4. doi request reprint Objective criteria for crohn-like lymphoid reaction in colorectal cancer
    Hideki Ueno
    Dept of Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Am J Clin Pathol 139:434-41. 2013
    ..67 for the 1-mm rule and 0.50 for Graham's criteria. The size of the largest LA best reflects the specific characteristics of CLR, and the 1-mm rule is expected to improve assessment reproducibility...
  5. doi request reprint Optimal colorectal cancer staging criteria in TNM classification
    Hideki Ueno
    National Defense Medical College, Tokorozawa, Japan
    J Clin Oncol 30:1519-26. 2012
    ..TNM classification revisions provide different criteria for categorizing tumor nodules without residual lymph node structure (ND). However, there are few systematic evaluations regarding the effectiveness of these revisions...
  6. doi request reprint Multicenter study for optimal categorization of extramural tumor deposits for colorectal cancer staging
    Hideki Ueno
    Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
    Ann Surg 255:739-46. 2012
    ..This study aimed to determine the optimal categorization of extramural tumor deposits lacking residual lymph node (LN) structure (EX) in colorectal cancer staging...
  7. doi request reprint New criteria for histologic grading of colorectal cancer
    Hideki Ueno
    Department of Surgery, National Defense Medical College Hospital, Japan
    Am J Surg Pathol 36:193-201. 2012
    ..It could be valuable in determining individualized postoperative CRC treatment...
  8. pmc Potential prognostic benefit of lateral pelvic node dissection for rectal cancer located below the peritoneal reflection
    Hideki Ueno
    Department of Surgery I, National Defense Medical College, Tokorozawa, Saitama, Japan
    Ann Surg 245:80-7. 2007
    ..To identify the parameters related to the effective selection of patients who could receive prognostic benefit from lateral pelvic node dissection...
  9. doi request reprint Growth pattern in the muscular layer reflects the biological behaviour of colorectal cancer
    H Ueno
    Department of Surgery, National Defense Medical College, 3 2, Namiki, Tokorozawa, Saitama 359 8513, Japan
    Colorectal Dis 11:951-9. 2009
    ..To determine the clinical value of evaluating the cancer morphology in muscularis propria (MP) for colorectal cancer (CRC) patients...
  10. doi request reprint Actual status of distribution and prognostic impact of extramural discontinuous cancer spread in colorectal cancer
    Hideki Ueno
    Department of Surgery, National Defense Medical College, 3 2, Namiki, Tokorozawa, Saitama 359 8513, Japan
    J Clin Oncol 29:2550-6. 2011
    ..To clarify the prognostic impact of tumor nodules without residual lymph node (LN) structure (ND) in colorectal cancer and to determine optimal categorization of ND in tumor staging...
  11. doi request reprint Histological grading of colorectal cancer: a simple and objective method
    Hideki Ueno
    Department of Surgery, National Defense Medical College, Tokorozawa, Saitama 359 8513, Japan
    Ann Surg 247:811-8. 2008
    ..The aim of this study was to determine whether the extent of the poorly differentiated component (POR) could be a valuable criterion for a grading system...
  12. ncbi request reprint Extramural cancer deposits without nodal structure in colorectal cancer: optimal categorization for prognostic staging
    Hideki Ueno
    Department of Surgery, National Defense Medical College, Namiki, Tokorozawa, Saitama, Japan
    Am J Clin Pathol 127:287-94. 2007
    ..The clinical significance of the TNM grading system for colorectal cancer would be enhanced if we treat EX as a new categorization...
  13. doi request reprint Pretreatment CD133 and cyclooxygenase-2 expression as the predictive markers of the pathological effect of chemoradiotherapy in rectal cancer patients
    Eiji Shinto
    Department of Surgery, National Defense Medical College, Saitama, Japan
    Dis Colon Rectum 54:1098-106. 2011
    ..CD133 confers chemoradioresistance properties to cells and has recently been used to identify cancer-initiating cells...
  14. doi request reprint Objective criteria for the grading of venous invasion in colorectal cancer
    Taichi Sato
    Department of Surgery, National Defense Medical College, Tokorozawa, Japan
    Am J Surg Pathol 34:454-62. 2010
    ..To establish an objective histologic grading system of venous invasion...
  15. doi request reprint Predicting oncologic outcomes by stratifying mesorectal extension in patients with pT3 rectal cancer: a Japanese multi-institutional study
    Yoshito Akagi
    Department of Surgery, Kurume University School of Medicine, Fukuoka, Japan
    Int J Cancer 131:1220-7. 2012
    ..These findings warrant further prospective studies to determine the reliability and validity of this cut-off point...
  16. pmc Preoperative parameters expanding the indication of sphincter preserving surgery in patients with advanced low rectal cancer
    Hideki Ueno
    Department of Surgery I, National Defense Medical College, Saitama, Japan
    Ann Surg 239:34-42. 2004
    ..To clarify the preoperative parameters of the required distal margin that can be applied to the criteria of sphincter-preserving surgery in rectal cancer...
  17. doi request reprint Differential clinical benefits of 5-fluorouracil-based adjuvant chemotherapy for patients with stage III colorectal cancer according to CD133 expression status
    Atsushi Shikina
    Department of Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama, Japan
    Jpn J Clin Oncol 44:42-8. 2014
    ..The objective of the study was to determine the relationship between clinical benefits of adjuvant chemotherapy and CD133 expression status in colorectal cancer...
  18. doi request reprint Site-specific tumor grading system in colorectal cancer: multicenter pathologic review of the value of quantifying poorly differentiated clusters
    Hideki Ueno
    Departments of Surgery Laboratory Medicine Laboratory for Mathematics, National Defense Medical College, Saitama Department of Surgery, Teikyo University School of Medicine Department of Surgery, International Medical Center of Japan Department of Surgery, Kyorin University School of Medicine Department of Surgery II, Tokyo Women s Medical University Department of Surgery, Tokyo Medical and Dental University, Tokyo Department of Surgery, Coloproctology Center, Takano Hospital, Kumamoto Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata Division of Gastrointestinal Surgery, Shizuoka Cancer Center Hospital, Shizuoka First Department of Surgery, University of Yamanashi, Yamanashi Department of Surgical Pathology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto Department of Surgical Oncology, Colorectal and Pelvic Surgery Division, National Cancer Center Hospital East, Chiba Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan
    Am J Surg Pathol 38:197-204. 2014
    ..40 for Grade(AJCC) and 0.52 for Grade(PDC). Grade(PDC) has a robust prognostic power and promises to be of sufficient clinical value to merit implementation as a site-specific grading system in CRC...
  19. doi request reprint Impact of race/ethnicity on prognosis in patients who underwent surgery for colon cancer: analysis for white, African, and East Asian Americans
    Yojiro Hashiguchi
    Department of Surgery, National Defense Medical College, Saitama, Japan
    Ann Surg Oncol 19:1517-28. 2012
    ..We retrospectively investigated the impact of race/ethnicity on prognosis in patients who underwent surgery for colon cancer...
  20. doi request reprint Clinical significance of the mesorectal extension of rectal cancer: a Japanese multi-institutional study
    Kazuo Shirouzu
    Department of Surgery, Kurume University School of Medicine, Fukuoka, Japan
    Ann Surg 253:704-10. 2011
    ..The aim of this study was to emphasize the importance of a subclassification in the TNM staging system of rectal cancer...
  21. ncbi request reprint Differential prognostic significance of morphologic invasive markers in colorectal cancer: tumor budding and cytoplasmic podia
    Eiji Shinto
    Department of Pathology II, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Dis Colon Rectum 49:1422-30. 2006
    ..In this study, we have investigated the prognostic significance of cytoplasmic podia...
  22. doi request reprint Risk factors of nodal involvement in T2 colorectal cancer
    Yoshiki Kajiwara
    Department of Surgery, National Defense Medical College, Saitama, Japan
    Dis Colon Rectum 53:1393-9. 2010
    ..We therefore conducted a retrospective study of patients with T2 colorectal cancer to identify risk factors for nodal involvement that might be used in selecting patients for local excision...
  23. doi request reprint Characterization of perineural invasion as a component of colorectal cancer staging
    Hideki Ueno
    Departments of Surgery Laboratory Medicine Laboratory for Mathematics, National Defense Medical College, Tokorozawa Department of Surgery, Kurume University Faculty of Medicine, Kurume Departments of Human Pathology Surgery, Tokyo Medical and Dental University Department of Pathology, National Cancer Center Hospital Department of Pathology, Jikei University School of Medicine, Tokyo Department of Surgery, Coloproctology Center, Takano Hospital, Kumamoto Department of Surgery, Keiyukai Sappro Hospital, Sapporo Department of Surgery, Hirosaki University School of Medicine, Hirosaki Department of Surgery, Kinki University School of Medicine, Osakasayama Department of Surgery, Yamagata Prefectural Central Hospital, Yamagata Division of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Sciences, Course for Molecular and Cellular Medicine, Niigata University, Niigata Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    Am J Surg Pathol 37:1542-9. 2013
    ..The value of cancer staging could be enhanced by PN assessment using site-specific criteria and a simple grading system based on PN location within the bowel. ..
  24. ncbi request reprint Prognostic implication of laminin-5 gamma 2 chain expression in the invasive front of colorectal cancers, disclosed by area-specific four-point tissue microarrays
    Eiji Shinto
    Department of Pathology II, National Defense Medical College, Tokorozawa, Japan
    Lab Invest 85:257-66. 2005
    ..Analysis using area-specific four-point TMAs clearly demonstrated that LN-5gamma2 expression in the invasive front largely influences the degree of clinical aggressiveness of CRC and its tendency to metastasize...
  25. ncbi request reprint T1 neuroendocrine carcinoma of anal canal after transanal resection for intramucosal adenocarcinoma
    Hirotoshi Kobayashi
    Department of Surgery I, National Defense Medical College, Tokorozawa, Saitama, Japan
    Jpn J Clin Oncol 36:325-8. 2006
    ..In this case, it is likely that the neuroendocrine tumor, which infiltrated into the submucosal layer with venous invasion, had developed over the intervening 13 months following the original transanal excision of the adenocarcinoma...
  26. doi request reprint Proposed objective criteria for "grade 3" in early invasive colorectal cancer
    Hideki Ueno
    Dept of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
    Am J Clin Pathol 134:312-22. 2010
    ..016). In cases of locally excised T1 CRC, G3 as determined by the proposed criteria, vascular invasion, and budding would comprise a useful combination of parameters for determining the indication for additional laparotomy...
  27. ncbi request reprint Heterogeneity of metalloproteinase expression in colorectal cancer - relation of molecular findings to basic morphology
    Yoshiki Kajiwara
    Department of Surgery, National Defense Medical College, Saitama, Japan
    Anticancer Res 31:1567-75. 2011
    ..To clarify the correlation between morphological features and the mRNA expression of a disintegrin and metalloproteinases (ADAMs) and matrix metalloproteinases (MMPs) in colorectal cancer...
  28. pmc Extent of mesorectal tumor invasion as a prognostic factor after curative surgery for T3 rectal cancer patients
    Masayoshi Miyoshi
    National Defense Medical College, Saitama, Japan
    Ann Surg 243:492-8. 2006
    ..To determine the significance of the extent of mesorectal tumor invasion as a prognostic factor for T3 rectal cancer patients...
  29. ncbi request reprint Histologic indices in biopsy specimens for estimating the probability of extended local spread in patients with rectal carcinoma
    Hideki Ueno
    Department of Surgery I, National Defense Medical College, Tokorozawa, Saitama, Japan
    Cancer 94:2882-91. 2002
    ..The aim of this study was to establish effective preoperative indices that would predict the degree of local spread in patients with rectal carcinoma...
  30. ncbi request reprint Absence of cyclooxygenase-2 protein expression is a predictor of tumor regression in rectal cancer treated with preoperative short-term chemoradiotherapy
    Hirotoshi Kobayashi
    Department of Surgery, National Defense Medical College, Saitama, Japan
    Dis Colon Rectum 50:1354-62. 2007
    ..This study was designed to determine whether pretreatment cyclooxygenase-2 and p53 protein expression were predictors of histopathologic response in patients with rectal cancer treated with preoperative short-term chemoradiotherapy...
  31. doi request reprint Lack of preoperative enteral nutrition reduces gut-associated lymphoid cell numbers in colon cancer patients: a possible mechanism underlying increased postoperative infectious complications during parenteral nutrition
    Koichi Okamoto
    Department of Surgery, National Defense Medical College, Saitama Surgical center, the University of Tokyo Department of Surgery, Teikyo University School of Medicine, Tokyo Division of Basic Traumatology, National Defense Medical College Research Institute, Saitama, Japan
    Ann Surg 258:1059-64. 2013
    ..To examine preoperative dietary influences on gut-associated lymphoid tissue (GALT) cell number in the context of postoperative infectious complications...
  32. doi request reprint Prognostic significance of the number of lymph nodes examined in colon cancer surgery: clinical application beyond simple measurement
    Yojiro Hashiguchi
    Department of Surgery, National Defense Medical College, Saitama, Japan
    Ann Surg 251:872-81. 2010
    ....
  33. doi request reprint Expression of l1 cell adhesion molecule and morphologic features at the invasive front of colorectal cancer
    Yoshiki Kajiwara
    Department of Surgery, National Defense Medical College, 3 2, Namiki, Tokorozawa, Saitama 359 8513, Japan
    Am J Clin Pathol 136:138-44. 2011
    ..0004). L1CAM expression was correlated with nodal involvement in protein and mRNA levels (P = .0007 and P = .036, respectively). Tumor regulation of L1CAM expression is associated with morphologic features at the invasive front in CRC...
  34. ncbi request reprint The subserosal elastic lamina: an anatomic landmark for stratifying pT3 colorectal cancer
    Eiji Shinto
    Department of Surgery 1, National Defense Medical College, Saitama, Japan
    Dis Colon Rectum 47:467-73. 2004
    ..The purpose of this study is to evaluate the significance of histologic invasion beyond subserosal elastic lamina by colorectal carcinoma for postoperative recurrence and long-term survival after resection...
  35. ncbi request reprint Risk factors for an adverse outcome in early invasive colorectal carcinoma
    Hideki Ueno
    Department of Surgery I, National Defense Medical College, Saitama, Japan
    Gastroenterology 127:385-94. 2004
    ..Various histologic findings exist for managing patients with malignant polyps. Our goal was to determine the criteria for a conservative approach to patients with locally excised early invasive carcinoma...
  36. ncbi request reprint Extranodal cancer deposit at the primary tumor site and the number of pulmonary lesions are useful prognostic factors after surgery for colorectal lung metastases
    Keiichi Ishikawa
    Department of Surgery I, National Defense Medical College, Tokorozawa, Saitama, Japan
    Dis Colon Rectum 46:629-36. 2003
    ..This study was undertaken to identify prognostic factors that can be used to predict prognosis after surgery for lung metastases from colorectal carcinoma...
  37. ncbi request reprint Tumor budding at the invasive margin can predict patients at high risk of recurrence after curative surgery for stage II, T3 colon cancer
    Masafumi Tanaka
    Department of Surgery I, National Defense Medical College, Tokorozawa, Japan
    Dis Colon Rectum 46:1054-9. 2003
    ..The aim of this study was to identify indicators that can predict patients at high risk of tumor recurrence in Stage II, T3 colon cancer...
  38. ncbi request reprint Distribution of lymph node metastasis is a prognostic index in patients with stage III colon cancer
    Hirotoshi Kobayashi
    Department of Surgery I, National Defense Medical College, Saitama, Japan
    Surgery 139:516-22. 2006
    ..The aim of our study was to examine whether the concept of the distribution of nodal metastasis could improve the TNM classification for colorectal cancer...
  39. ncbi request reprint [Chemoradiation combined with total mesorectal excision for patients with locally advanced rectal cancer]
    Kazuo Hase
    Department of Surgery, National Defense Medical College, Tokorozawa, Japan
    Nihon Geka Gakkai Zasshi 112:313-7. 2011
    ..The precise prediction of tumor response and advances in CRT regimens resulting in better survival may improve the treatment of rectal cancer in the future...
  40. ncbi request reprint [A case of long-term survival after resection of advanced undifferentiated rectal cancer treated by short-term preoperative chemoradiotherapy and postoperative adjuvant chemotherapy]
    Yoshihisa Naito
    Dept of Surgery, National Defense Medical College, Japan
    Gan To Kagaku Ryoho 38:117-20. 2011
    ....
  41. pmc A new prognostic staging system for rectal cancer
    Hideki Ueno
    Department of Surgery I, National Defense Medical College, Japan
    Ann Surg 240:832-9. 2004
    ..To clarify the appropriateness of tumor "budding," a quantifiable histologic variable, as 1 parameter in the construction of a new prognostic grading system for rectal cancer...
  42. ncbi request reprint [Surveillance after curative resection for colorectal cancer]
    Yojiro Hashiguchi
    Department of Surgery, National Defense Medical College, Tokorozawa, Japan
    Nihon Geka Gakkai Zasshi 108:125-30. 2007
    ..Periodic follow-up for metachronous multicentric colorectal cancers should be recommended. Further studies will be necessary to validate the efficacy of intensive follow-up...
  43. ncbi request reprint [Risk factors and prevention of surgical site infection for colorectal surgery]
    Suefumi Aosasa
    Department of Surgery, National Defense Medical College
    Nihon Rinsho 72:150-3. 2014
    ..Furthermore, this review will focus on the prevention of SSI and refer to colon preparation and preventive antibiotics for colorectal surgery...
  44. doi request reprint Elevated preoperative C-reactive protein levels are a risk factor for the development of postoperative infectious complications following elective colorectal surgery
    Toru Kubo
    Department of Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama, 359 8513, Japan
    Langenbecks Arch Surg 398:965-71. 2013
    ..The present study was designed to evaluate the relationship between the preoperative C-reactive protein levels and the incidence of postoperative infectious complications in patients undergoing colorectal surgery...
  45. doi request reprint Right-sided retrocaval approach using guidance via the lesser sac for Spieghel lobe resection
    Junji Yamamoto
    Department of Surgery, National Defense Medical College, Saitama, Japan
    Surgery 153:282-6. 2013
    ..Few reports describe technical problems encountered in resections of the Spieghel lobe of the liver...
  46. ncbi request reprint [Oncologic emergencies in colorectal cancer patients]
    Hideki Ueno
    Department of Surgery I, National Defense Medical College, Saitama, Japan
    Nihon Geka Gakkai Zasshi 105:286-91. 2004
    ..Intensive management to prevent sepsis including continuous blood purification methods such as polymixin B-immobilized fiber hemofiltration and continuous hemodiafiltration is required to improve the perioperative mortality rate...
  47. doi request reprint Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo, 173 8605, Japan
    Int J Clin Oncol 17:1-29. 2012
    ..Here we present the English version of the JSCCR Guidelines 2010...
  48. ncbi request reprint Analysis of prognostic factors affecting survival after initial recurrence and treatment efficacy for recurrence in patients undergoing potentially curative hepatectomy for hepatocellular carcinoma
    Kazuaki Shimada
    Division of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Tokyo, Japan
    Ann Surg Oncol 14:2337-47. 2007
    ..In addition, selections of the most effective treatments for patients with recurrent HCC still remain controversial...
  49. ncbi request reprint Prognostic factors in patients with advanced biliary tract cancer receiving chemotherapy
    Toshimitsu Saisho
    Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    Hepatogastroenterology 52:1654-8. 2005
    ..Prognostic factors in patients with advanced biliary tract cancer receiving chemotherapy have not been fully examined. This study investigated prognostic factors in patients with advanced biliary tract cancer receiving chemotherapy...
  50. ncbi request reprint Phase II study of uracil-tegafur in patients with metastatic pancreatic cancer
    Hideki Ueno
    Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    Oncology 62:223-7. 2002
    ..However, its activity in pancreatic cancer has not been fully evaluated. The aim of the present study was to evaluate the anti-tumor activity and toxicity of UFT in patients with metastatic pancreatic cancer...
  51. ncbi request reprint Early phase II study of uracil-tegafur plus doxorubicin in patients with unresectable advanced biliary tract cancer
    Junji Furuse
    National Cancer Center Hospital East, Kashiwa, Chiba 277 8577, Japan
    Jpn J Clin Oncol 36:552-6. 2006
    ..The purpose of this study was to evaluate the efficacy and toxicity of a combination chemotherapy of uracil-tegafur (UFT) and doxorubicin in patients with unresectable advanced biliary tract cancer...
  52. ncbi request reprint Long-term outcomes in patients with metastatic melanoma vaccinated with melanoma peptide-pulsed CD34(+) progenitor-derived dendritic cells
    Joseph W Fay
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
    Cancer Immunol Immunother 55:1209-18. 2006
    ..The present results therefore justify the design of larger follow-up studies to assess the immunological and clinical outcomes in patients with metastatic melanoma vaccinated with peptide-pulsed CD34-derived DCs...
  53. ncbi request reprint Phase I study of fixed dose rate infusion of gemcitabine in patients with unresectable pancreatic cancer
    Junji Furuse
    Division of Hepatobiliary and Pancreatic Medical Oncology, National Cancer Center Hospital East, Kashiwa, Chiba 277 8577, Japan
    Jpn J Clin Oncol 35:733-8. 2005
    ..The purpose of this study was to determine the feasible dose of gemcitabine when administered as a fixed dose rate infusion (10 mg/m(2)/min) on a weekly schedule to Japanese patients with unresectable advanced pancreatic cancer...
  54. ncbi request reprint Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon
    Jacques Banchereau
    Baylor Institute for Immunology Research, Dallas, TX, USA
    J Immunother 28:505-16. 2005
    ..Overall, these results suggest that IFN-alpha-activated CD34-DCs are safe but elicit only limited immune responses, underscoring the need to test different DC maturation factors...
  55. ncbi request reprint A phase II trial of Uracil-tegafur (UFT) in patients with advanced biliary tract carcinoma
    Masafumi Ikeda
    Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 35:439-43. 2005
    ..However, its activity in biliary tract carcinoma has not been fully evaluated. The aim of this study was to evaluate the antitumor activity and toxicity of UFT in chemotherapy-naive patients with advanced biliary tract carcinoma...
  56. ncbi request reprint Chemoradiotherapy for locally advanced pancreatic carcinoma in elderly patients
    Chigusa Morizane
    Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    Oncology 68:432-7. 2005
    ..This study investigated the outcome and tolerability of this treatment in elderly patients...
  57. ncbi request reprint A phase II trial of continuous infusion of 5-fluorouracil, mitoxantrone, and cisplatin for metastatic hepatocellular carcinoma
    Masafumi Ikeda
    Division of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan
    Cancer 103:756-62. 2005
    ....
  58. ncbi request reprint [Chemotherapy for hepatocellular carcinoma]
    Takuji Okusaka
    Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Gan To Kagaku Ryoho 31:2122-8. 2004
    ..No agent has reproducibly documented a high response rate, and few chemotherapeutic regimens show meaningful impact on patient survival. Numerous clinical trials have been conducted to establish effective treatment for patients with HCC...
  59. ncbi request reprint Phase I study of hyperfractionated radiation therapy with protracted 5-fluorouracil infusion in patients with locally advanced pancreatic cancer
    Hideki Ueno
    Division of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan
    Oncology 67:215-21. 2004
    ..This study investigated the maximum-tolerated dose of hyperfractionated radiation therapy with protracted 5-fluorouracil (5-FU) infusion in patients with locally advanced, unresectable pancreatic cancer...
  60. ncbi request reprint Small-field radiotherapy in combination with concomitant chemotherapy for locally advanced pancreatic carcinoma
    Koichi Tokuuye
    Radiation Oncology Division, The National Cancer Center Hospital, Tokyo, Japan
    Radiother Oncol 67:327-30. 2003
    ..To evaluate the effectiveness of small-field radiotherapy in combination with concomitant 5-fluorouracil (5FU) or cisplatin for locally advanced pancreatic carcinoma...
  61. ncbi request reprint Prognostic factors in patients with hepatocellular carcinoma treated by transcatheter arterial embolization
    Masafumi Ikeda
    Division of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan
    Jpn J Clin Oncol 32:455-60. 2002
    ..This study investigated prognostic factors in patients with advanced hepatocellular carcinoma treated by transcatheter arterial embolization...
  62. ncbi request reprint Prognostic factors in patients with small hepatocellular carcinoma treated by percutaneous ethanol injection
    Hitoshi Kuriyama
    Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    J Gastroenterol Hepatol 17:1205-10. 2002
    ..However, only a few extensive investigations have been conducted regarding the prognostic factors for HCC patients treated with PEI...
  63. ncbi request reprint Tumor buds show reduced expression of laminin-5 gamma 2 chain in DNA mismatch repair deficient colorectal cancer
    Eiji Shinto
    Department of Pathology, McGill University, Montreal, Canada
    Dis Colon Rectum 49:1193-202. 2006
    ..It is hypothesized that tumor budding in this subset may lack biologic aggressiveness because it is not associated with aberrant expression of the independent prognostic factor, laminin-5 gamma 2...
  64. ncbi request reprint A phase I/II study of combination chemotherapy with gemcitabine and 5-fluorouracil for advanced pancreatic cancer
    Takuji Okusaka
    Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, Tokyo, 104 0045, Japan
    Jpn J Clin Oncol 36:557-63. 2006
    ..We thus conducted a phase I/II study of gemcitabine and infusional 5-FU in Japanese patients to determine a recommended dosage for this combination and clarify efficacy and toxicity...
  65. doi request reprint Predictive factors of outcome and tumor response to systemic chemotherapy in patients with metastatic hepatocellular carcinoma
    Masafumi Ikeda
    Division of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Jpn J Clin Oncol 38:675-82. 2008
    ..The aim of this study was to identify factors that could be used to predict outcome and tumor response to systemic chemotherapy in patients with metastatic HCC...
  66. doi request reprint His595Tyr polymorphism in the methionine synthase reductase (MTRR) gene is associated with pancreatic cancer risk
    Shumpei Ohnami
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 135:477-88. 2008
    ..This study attempts to elucidate a part of the genetic predisposition to the sporadic invasive ductal adenocarcinoma of the pancreas focusing on the genes implicated in the gene-environment interactions in carcinogenesis...
  67. doi request reprint Ultrasound-guided percutaneous pancreatic tumor biopsy in pancreatic cancer: a comparison with metastatic liver tumor biopsy, including sensitivity, specificity, and complications
    Junichi Matsubara
    Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Tokyo, 104 0045, Japan
    J Gastroenterol 43:225-32. 2008
    ....
  68. ncbi request reprint FP therapy for controlling malignant ascites in advanced pancreatic cancer patients
    Kan Yonemori
    Division of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan
    Hepatogastroenterology 54:2383-6. 2007
    ..We conducted a retrospective analysis to evaluate the efficacy of 5-fluorouracil (5-FU) plus cisplatin (FP therapy) for controlling malignant ascites in patients with advanced pancreatic cancer...
  69. ncbi request reprint Hepatic arterial infusion chemotherapy with epirubicin in patients with advanced hepatocellular carcinoma and portal vein tumor thrombosis
    Masafumi Ikeda
    Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    Oncology 72:188-93. 2007
    ..The objective of this study was to evaluate the antitumor, survival, and adverse effects of hepatic arterial infusion chemotherapy using epirubicin in patients with advanced hepatocellular carcinoma and portal vein tumor thrombosis...
  70. ncbi request reprint [Two cases of advanced extrahepatic bile duct cancer successfully treated by S-1 monotherapy]
    Hideki Ueno
    Division of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital
    Gan To Kagaku Ryoho 34:1311-4. 2007
    ..0%. In this article,we report two patients with advanced extrahepatic bile duct cancer enrolled in the study who showed a partial response to S-1 monotherapy...
  71. ncbi request reprint Phase II study of combination chemotherapy with gemcitabine and cisplatin for patients with metastatic pancreatic cancer
    Hideki Ueno
    Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    Jpn J Clin Oncol 37:515-20. 2007
    ..The objectives of this study were to evaluate the efficacy and toxicity of combination chemotherapy with gemcitabine and cisplatin in patients with metastatic pancreatic cancer...
  72. ncbi request reprint A phase II trial of transcatheter arterial infusion chemotherapy with an epirubicin-Lipiodol emulsion for advanced hepatocellular carcinoma refractory to transcatheter arterial embolization
    Tsutomu Tanaka
    Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    Cancer Chemother Pharmacol 61:683-8. 2008
    ..The aim of this study was to evaluate the antitumor activity and toxicity of transcatheter arterial infusion chemotherapy using an epirubicin-Lipiodol emulsion in patients with TAE-refractory HCC...
  73. ncbi request reprint [Two patients effectively treated by S-1 monotherapy for metastatic pancreatic cancer]
    Masafumi Ikeda
    Division of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital
    Gan To Kagaku Ryoho 33:1515-9. 2006
    ..S-1 showed a promising antitumor effect and tolerability in patients with metastatic pancreatic cancer, and it was also considered to be beneficial for patients in terms of convenience of administration, that is, by the oral route...
  74. ncbi request reprint Dendritic cells loaded with killed allogeneic melanoma cells can induce objective clinical responses and MART-1 specific CD8+ T-cell immunity
    Anna K Palucka
    Baylor Institute for Immunology Research, Sammons Cancer Center, 3434 Live Oak, Dallas, TX 75204, USA
    J Immunother 29:545-57. 2006
    ..Thus, the present results justify the design of larger follow-up studies to assess the clinical response to DC vaccines loaded with killed allogeneic tumor cells in patients with metastatic melanoma...
  75. ncbi request reprint [S-1 monotherapy for pancreatic cancer]
    Takuji Okusaka
    Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    Gan To Kagaku Ryoho 33:207-12. 2006
    ..S-1 is active and well tolerated in patients with metastatic pancreatic cancer. Randomized trials are warranted to determine the effectiveness of S-1 for the treatment of pancreatic cancer...
  76. ncbi request reprint Transcatheter arterial embolization with zinostatin stimalamer for hepatocellular carcinoma
    Takuji Okusaka
    Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    Oncology 62:228-33. 2002
    ..Grade 3 and 4 non-hematological toxicity (liver dysfunction) occurred in 17 (34%) and 7 patients (14%), respectively. TAE using SMANCS, which was well tolerated, may be an effective treatment for advanced HCC...