Hirohiko Tsujii

Summary

Affiliation: National Institute of Radiological Sciences
Country: Japan

Publications

  1. ncbi request reprint Overview of clinical experiences on carbon ion radiotherapy at NIRS
    Hirohiko Tsujii
    Research Center for Charged Particle Therapy National Institute of Radiological Sciences, Chiba, Japan
    Radiother Oncol 73:S41-9. 2004
  2. pmc A review of update clinical results of carbon ion radiotherapy
    Hirohiko Tsujii
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Jpn J Clin Oncol 42:670-85. 2012
  3. pmc In vitro characterization of cells derived from chordoma cell line U-CH1 following treatment with X-rays, heavy ions and chemotherapeutic drugs
    Takamitsu A Kato
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba shi, 263 8555 Japan
    Radiat Oncol 6:116. 2011
  4. ncbi request reprint Carbon ion radiotherapy: clinical experiences at National Institute of Radiological Science (NIRS)
    Tohru Okada
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage, Chiba 263 8555, Japan
    J Radiat Res 51:355-64. 2010
  5. doi request reprint Application of carbon-ion beams or gamma-rays on primary tumors does not change the expression profiles of metastatic tumors in an in vivo murine model
    Tomoaki Tamaki
    RadGenomics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 74:210-8. 2009
  6. doi request reprint Carbon ion radiotherapy for unresectable retroperitoneal sarcomas
    Itsuko Serizawa
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    Int J Radiat Oncol Biol Phys 75:1105-10. 2009
  7. ncbi request reprint Carbon ion radiation therapy for prostate cancer: results of a prospective phase II study
    Hitoshi Ishikawa
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage Ku, Chiba City, Japan
    Radiother Oncol 81:57-64. 2006
  8. ncbi request reprint Carbon ion radiotherapy for stage I non-small cell lung cancer using a regimen of four fractions during 1 week
    Tadaaki Miyamoto
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    J Thorac Oncol 2:916-26. 2007
  9. doi request reprint Carbon ion radiotherapy for elderly patients 80 years and older with stage I non-small cell lung cancer
    Toshio Sugane
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Lung Cancer 64:45-50. 2009
  10. ncbi request reprint Carbon ion radiotherapy for stage I non-small cell lung cancer
    Tadaaki Miyamoto
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, 9 1 Anagawa, 4 chome, Inage Ku, Chiba shi 263 8555, Japan
    Radiother Oncol 66:127-40. 2003

Collaborators

Detail Information

Publications82

  1. ncbi request reprint Overview of clinical experiences on carbon ion radiotherapy at NIRS
    Hirohiko Tsujii
    Research Center for Charged Particle Therapy National Institute of Radiological Sciences, Chiba, Japan
    Radiother Oncol 73:S41-9. 2004
    ..This study summarizes the experiences of carbon ion radiotherapy at the Heavy Ion Medical Accelerator in Chiba (HIMAC) at the National Institute of Radiological Sciences...
  2. pmc A review of update clinical results of carbon ion radiotherapy
    Hirohiko Tsujii
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Jpn J Clin Oncol 42:670-85. 2012
    ..This review describes clinical results of carbon ion radiotherapy together with physical, biological and technological aspects of carbon ions...
  3. pmc In vitro characterization of cells derived from chordoma cell line U-CH1 following treatment with X-rays, heavy ions and chemotherapeutic drugs
    Takamitsu A Kato
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba shi, 263 8555 Japan
    Radiat Oncol 6:116. 2011
    ..In order to overcome this situation, we successfully derived a cell line with a shorter doubling time from the first validated chordoma line U-CH1 and obtained invaluable cell biological data...
  4. ncbi request reprint Carbon ion radiotherapy: clinical experiences at National Institute of Radiological Science (NIRS)
    Tohru Okada
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage, Chiba 263 8555, Japan
    J Radiat Res 51:355-64. 2010
    ..This means that carbon ion radiotherapy can offer treatment for larger numbers of patients than is possible with other modalities over the same time period...
  5. doi request reprint Application of carbon-ion beams or gamma-rays on primary tumors does not change the expression profiles of metastatic tumors in an in vivo murine model
    Tomoaki Tamaki
    RadGenomics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 74:210-8. 2009
    ..To clarify how carbon-ion radiotherapy (C-ion) on primary tumors affects the characteristics of subsequently arising metastatic tumor cells...
  6. doi request reprint Carbon ion radiotherapy for unresectable retroperitoneal sarcomas
    Itsuko Serizawa
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    Int J Radiat Oncol Biol Phys 75:1105-10. 2009
    ..To evaluate the applicability of carbon ion radiotherapy (CIRT) for unresectable retroperitoneal sarcomas with regard to normal tissue morbidity and local tumor control...
  7. ncbi request reprint Carbon ion radiation therapy for prostate cancer: results of a prospective phase II study
    Hitoshi Ishikawa
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage Ku, Chiba City, Japan
    Radiother Oncol 81:57-64. 2006
    ..To determine the efficacy and feasibility of carbon ion radiotherapy (C-ion RT) for prostate cancer...
  8. ncbi request reprint Carbon ion radiotherapy for stage I non-small cell lung cancer using a regimen of four fractions during 1 week
    Tadaaki Miyamoto
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    J Thorac Oncol 2:916-26. 2007
    ..On the basis on the results, a phase II study using a regimen of four fractions during 1 week was performed. The purpose of the present study was to determine the local control and 5-year survival rates...
  9. doi request reprint Carbon ion radiotherapy for elderly patients 80 years and older with stage I non-small cell lung cancer
    Toshio Sugane
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Lung Cancer 64:45-50. 2009
    ..8%, and the 5-year overall survival rate was 30.7%, but there were no patients who started home oxygen therapy or had decreased ADL. Our data demonstrate that CIRT was effective in treating elderly patients with stage I NSCLC...
  10. ncbi request reprint Carbon ion radiotherapy for stage I non-small cell lung cancer
    Tadaaki Miyamoto
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, 9 1 Anagawa, 4 chome, Inage Ku, Chiba shi 263 8555, Japan
    Radiother Oncol 66:127-40. 2003
    ..Using carbon beams, a dose escalation study was conducted for the treatment of stage I non-small cell lung cancer (NSCLC) to determine the optimal dose...
  11. doi request reprint Adverse effects of androgen deprivation therapy on persistent genitourinary complications after carbon ion radiotherapy for prostate cancer
    Hitoshi Ishikawa
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 72:78-84. 2008
    ..To determine the risk factors for persistent late genitourinary (GU) morbidity after carbon ion radiotherapy (C-ion RT) for prostate cancer...
  12. doi request reprint Susceptible genes and molecular pathways related to heavy ion irradiation in oral squamous cell carcinoma cells
    Kazuaki Fushimi
    Department of Clinical Molecular Biology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Radiother Oncol 89:237-44. 2008
    ..The aim of the current study was to determine the difference of gene expression between heavy ion beams and X-rays in oral squamous cell carcinoma (OSCC)-derived cells...
  13. ncbi request reprint Carbon-ion radiotherapy for locally advanced or unfavorably located choroidal melanoma: a Phase I/II dose-escalation study
    Hiroshi Tsuji
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 67:857-62. 2007
    ..To evaluate the applicability of carbon ion beams for the treatment of choroidal melanoma with regard to normal tissue morbidity and local tumor control...
  14. doi request reprint Carbon ion radiotherapy in advanced hypofractionated regimens for prostate cancer: from 20 to 16 fractions
    Tohru Okada
    National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 84:968-72. 2012
    ..To assess the effects of differences in dose fractionation on late radiation toxicity and biochemical control in patients with prostate cancer treated with carbon ion radiotherapy (C-ion RT)...
  15. ncbi request reprint Carbon beam therapy overcomes the radiation resistance of uterine cervical cancer originating from hypoxia
    Takashi Nakano
    Research Center Hospital of Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Clin Cancer Res 12:2185-90. 2006
    ..However, no proof of this effect has been provided by clinical trials and related clinical research. Hence, we investigated the radiation biological aspects of high LET carbon beam therapy on cervical cancer...
  16. doi request reprint Effect of carbon ion radiotherapy for sacral chordoma: results of Phase I-II and Phase II clinical trials
    Reiko Imai
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 77:1470-6. 2010
    ..To summarize the results of treatment for sacral chordoma in Phase I-II and Phase II carbon ion radiotherapy trials for bone and soft-tissue sarcomas...
  17. ncbi request reprint Risk factors of late rectal bleeding after carbon ion therapy for prostate cancer
    Hitoshi Ishikawa
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 66:1084-91. 2006
    ..The aim of this study was to determine the risk factors for late gastrointestinal (GI) morbidity after hypofractionated carbon ion radiotherapy (C-ion RT) for prostate cancer...
  18. ncbi request reprint Upregulation of stress-response genes with cell cycle arrest induced by carbon ion irradiation in multiple murine tumors models
    Kaori Imadome
    RadGenomics Project, National Institute of Radiological Sciences, Inage, Chiba, Japan
    Cancer Biol Ther 7:208-17. 2008
    ..To elucidate the in vivo biological effects induced by carbon-ion irradiation using comprehensive expression analysis...
  19. doi request reprint Malignant mucosal melanoma treated with carbon ion radiotherapy with concurrent chemotherapy: prognostic value of pretreatment apparent diffusion coefficient (ADC)
    Keiichi Jingu
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Japan
    Radiother Oncol 98:68-73. 2011
    ..To evaluate the potential of apparent diffusion coefficient (ADC) value before carbon ion radiotherapy (C-ion RT) for malignant mucosal melanoma (MMM) to predict prognosis...
  20. ncbi request reprint Local control and recurrence of stage I non-small cell lung cancer after carbon ion radiotherapy
    Masashi Koto
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba shi, Chiba 263 8555, Japan
    Radiother Oncol 71:147-56. 2004
    ....
  21. ncbi request reprint Dose escalation study of carbon ion radiotherapy for locally advanced carcinoma of the uterine cervix
    Shingo Kato
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 65:388-97. 2006
    ..To evaluate the toxicity and efficacy of carbon ion radiotherapy (CIRT) for locally advanced cervical cancer by two phase I/II clinical trials...
  22. doi request reprint Changes in tumor volume of sacral chordoma after carbon ion radiotherapy
    Itsuko Serizawa
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Anagawa 4 9 1, Inage Ku, Chiba 263 8555, Japan
    J Comput Assist Tomogr 33:795-8. 2009
    ..We evaluated changes in tumor volume in cases of sacral chordoma after carbon ion radiotherapy...
  23. doi request reprint Compensatory enlargement of the liver after treatment of hepatocellular carcinoma with carbon ion radiotherapy - relation to prognosis and liver function
    Hiroshi Imada
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    Radiother Oncol 96:236-42. 2010
    ..To examine whether liver volume changes affect prognosis and hepatic function in patients treated with carbon ion radiotherapy (CIRT) for hepatocellular carcinoma (HCC)...
  24. ncbi request reprint Late rectal complications evaluated by computed tomography-based dose calculations in patients with cervical carcinoma undergoing high-dose-rate brachytherapy
    Shin Ei Noda
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Anagawa, Chiba, Japan
    Int J Radiat Oncol Biol Phys 69:118-24. 2007
    ....
  25. doi request reprint Influence of multiple genetic polymorphisms on genitourinary morbidity after carbon ion radiotherapy for prostate cancer
    Tomo Suga
    RadGenomics Research Group, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 72:808-13. 2008
    ..To investigate the genetic risk of late urinary morbidity after carbon ion radiotherapy in prostate cancer patients...
  26. doi request reprint Carbon ion radiation therapy improves the prognosis of unresectable adult bone and soft-tissue sarcoma of the head and neck
    Keiichi Jingu
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences NIRS, Chiba, Japan
    Int J Radiat Oncol Biol Phys 82:2125-31. 2012
    ..To evaluate the safety and efficacy of carbon ion radiotherapy (C-ion RT) with 70.4 GyE for unresectable bone and soft-tissue sarcoma of the adult head and neck...
  27. doi request reprint The proangiogenic factor ephrin-A1 is up-regulated in radioresistant murine tumor by irradiation
    Kazunori Nojiri
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Exp Biol Med (Maywood) 234:112-22. 2009
    ..Our results suggest that radiotherapy-induced changes in gene expression related with angiogenesis might also modulate microenvironment and influence responsiveness of tumors...
  28. ncbi request reprint Results of the first prospective study of carbon ion radiotherapy for hepatocellular carcinoma with liver cirrhosis
    Hirotoshi Kato
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba shi 263 8555, Japan
    Int J Radiat Oncol Biol Phys 59:1468-76. 2004
    ..To evaluate the toxicity and antitumor effect of carbon ion radiotherapy for hepatocellular carcinoma within a Phase I-II trial...
  29. ncbi request reprint Carbon-11-methionine positron emission tomography imaging of chordoma
    Hong Zhang
    Department of Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan
    Skeletal Radiol 33:524-30. 2004
    ..This is the first trial to investigate the utility of (11)C-methionine (MET) positron emission tomography (PET) in the imaging of chordoma before and after carbon-ion radiotherapy (CIRT)...
  30. ncbi request reprint Noise properties for three weighted Feldkamp algorithms using a 256-detecotor row CT-scanner: case study for hepatic volumetric cine imaging
    Shinichiro Mori
    Department of Medical Physics, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Eur J Radiol 59:289-94. 2006
    ..We concluded that, considering the trade-off between image quality and temporal resolution, the NHS-FDK algorithm is useful in volumetric cine imaging for the abdomen...
  31. doi request reprint Carbon ion radiation therapy for primary renal cell carcinoma: initial clinical experience
    Takuma Nomiya
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences NIRS, Chiba, Japan
    Int J Radiat Oncol Biol Phys 72:828-33. 2008
    ..Renal cell carcinoma (RCC) is known as a radioresistant tumor, and there are few reports on radiotherapy for primary RCC. We evaluated the efficacy of carbon ion radiotherapy (CIRT) for patients with RCC...
  32. ncbi request reprint Curative treatment of Stage I non-small-cell lung cancer with carbon ion beams using a hypofractionated regimen
    Tadaaki Miyamoto
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences NIRS, Chiba, Japan
    Int J Radiat Oncol Biol Phys 67:750-8. 2007
    ..Second, a Phase II study using the optimal dose was performed. The purpose of the present study was to clarify the local control and 5-year survival rates...
  33. doi request reprint Mucosal malignant melanoma of the head and neck treated by carbon ion radiotherapy
    Takeshi Yanagi
    National Institute of Radiological Sciences, Research Center Hospital for Charged Particle Therapy, Chiba, Japan
    Int J Radiat Oncol Biol Phys 74:15-20. 2009
    ..To evaluate the efficacy of carbon ion radiotherapy for mucosal malignant melanoma of the head and neck...
  34. ncbi request reprint Examination of GyE system for HIMAC carbon therapy
    Tatsuaki Kanai
    Department of Medical Physics, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 64:650-6. 2006
    ....
  35. doi request reprint Dose-volume histogram and dose-surface histogram analysis for skin reactions to carbon ion radiotherapy for bone and soft tissue sarcoma
    Takeshi Yanagi
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Radiother Oncol 95:60-5. 2010
    ....
  36. doi request reprint 11C-methionine-PET for evaluation of carbon ion radiotherapy in patients with pelvic recurrence of rectal cancer
    Mitsuru Koizumi
    Diagnostic Imaging, Molecular Imaging Center, National Institute of Radiological Sciences, Anagawa 4 9 1, Inageku, Chiba, Japan
    Mol Imaging Biol 10:374-80. 2008
    ..We investigated whether L-[11C]methyl-methionine (11C-methionine) uptake at pre- and post-CIRT could be an early response predictor in patients with pelvic recurrence of rectal cancer...
  37. ncbi request reprint Dosimetric factors used for thoracic X-ray radiotherapy are not predictive of the occurrence of radiation pneumonitis after carbon-ion radiotherapy
    Masashi Koto
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Tohoku J Exp Med 213:149-56. 2007
    ..The dosimetric factors used for XRT are not applicable for CRT in patients with NSCLC. The dosimetric factors for CRT remain to be developed...
  38. doi request reprint Multi-institutional phase II clinical study of concurrent chemoradiotherapy for locally advanced cervical cancer in East and Southeast Asia
    Shingo Kato
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 77:751-7. 2010
    ....
  39. doi request reprint Gene expression analysis in human malignant melanoma cell lines exposed to carbon beams
    Yoshitaka Matsumoto
    Graduate School of Medicine, Chiba University, Chiba, Japan
    Int J Radiat Biol 84:299-314. 2008
    ..To elucidate the molecular changes in response to carbon beams (C-ions) in melanoma...
  40. doi request reprint Comparison of efficacy and toxicity of short-course carbon ion radiotherapy for hepatocellular carcinoma depending on their proximity to the porta hepatis
    Hiroshi Imada
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    Radiother Oncol 96:231-5. 2010
    ..To compare the efficacy and toxicity of short-course carbon ion radiotherapy (C-ion RT) for patients with hepatocellular carcinoma (HCC) in terms of tumor location: adjacent to the porta hepatis or not...
  41. ncbi request reprint Hypofractionated radiotherapy with carbon ion beams for prostate cancer
    Hiroshi Tsuji
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 63:1153-60. 2005
    ..Analysis of the results of hypofractionated conformal carbon ion radiotherapy for localized prostate cancer was performed, with special regard to normal tissue morbidity and biochemical relapse-free rate (bNED)...
  42. ncbi request reprint Enhancement of SPHK1 in vitro by carbon ion irradiation in oral squamous cell carcinoma
    Morihiro Higo
    Department of Clinical Molecular Biology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Int J Radiat Oncol Biol Phys 65:867-75. 2006
    ..The purpose of this study was to assess the gene expression changes in oral squamous cell carcinoma (OSCC) cells after carbon ion irradiation...
  43. ncbi request reprint Analysis of non-genetic risk factors for adverse skin reactions to radiotherapy among 284 breast cancer patients
    Mayumi Iwakawa
    RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba shi, Chiba ken 263 8555, Japan
    Breast Cancer 13:300-7. 2006
    ....
  44. ncbi request reprint Carbon ion radiotherapy for unresectable sacral chordomas
    Reiko Imai
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba
    Clin Cancer Res 10:5741-6. 2004
    ..The purpose is to evaluate the efficacy and toxicity of carbon ion radiotherapy for unresectable sacral chordomas...
  45. ncbi request reprint Carbon ion therapy for ocular melanoma: planning orthogonal two-port treatment
    Hiroko Koyama-Ito
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Phys Med Biol 52:5341-52. 2007
    ..For nine patients two-port treatment was assessed to be more effective than mono-port therapy and these patients were treated with two fractions of vertical beams and three fractions of horizontal beams...
  46. ncbi request reprint Preoperative carbon ion radiotherapy for non-small cell lung cancer with chest wall invasion--pathological findings concerning tumor response and radiation induced lung injury in the resected organs
    Naoyoshi Yamamoto
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, 9 1 Anagawa, 4 chome, Inage Ku, Chiba shi, Chiba 263 8555, Japan
    Lung Cancer 42:87-95. 2003
    ..The pathological findings have thus provided evidence of the safety and effectiveness of carbon beam therapy in the treatment of NSCLC...
  47. ncbi request reprint Dose escalation study of carbon ion radiotherapy for locally advanced head-and-neck cancer
    Jun etsu Mizoe
    Hospital, Research Center of Charged Particle, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 60:358-64. 2004
    ..To evaluate the toxicity and efficacy of carbon ion radiotherapy for head-and-neck cancer in a Phase I/II dose escalation clinical trial...
  48. ncbi request reprint Carbon ion radiotherapy for treatment of prostate cancer and subsequent outcomes after biochemical failure
    Jun Shimazaki
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Anticancer Res 30:5105-11. 2010
    ..The aim of this study was to examine long-term results and subsequent outcomes after biochemical failure...
  49. ncbi request reprint Phase I/II clinical trial of carbon ion radiotherapy for malignant gliomas: combined X-ray radiotherapy, chemotherapy, and carbon ion radiotherapy
    Jun etsu Mizoe
    Hospital, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 69:390-6. 2007
    ..To report the results of a Phase I/II clinical trial for patients with malignant gliomas, treated with combined X-ray radiotherapy (XRT), chemotherapy, and carbon ion radiotherapy (CRT)...
  50. doi request reprint Psychological distress and quality of life in cervical cancer survivors after radiotherapy: do treatment modalities, disease stage, and self-esteem influence outcomes?
    Mika Kobayashi
    Department of Social Psychiatry, National Institute of Mental Health, Chiba, Gunma, Japan
    Int J Gynecol Cancer 19:1264-8. 2009
    ..Psychosocial support with consideration of a patient's self-esteem is necessary throughout and beyond radiotherapy for cervical cancer...
  51. doi request reprint Prediction of early response to radiotherapy of uterine carcinoma with dynamic contrast-enhanced MR imaging using pixel analysis of MR perfusion imaging
    Yukihisa Takayama
    Biophysics Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Magn Reson Imaging 27:370-6. 2009
    ..To assess the predictability of the response to radiotherapy of uterine carcinoma, this study retrospectively analyzed dynamic contrast-enhanced magnetic resonance images (DCE-MRI) taken before radiotherapy...
  52. ncbi request reprint Clinical potentials for dynamic contrast-enhanced hepatic volumetric cine imaging with the prototype 256-MDCT scanner
    Shinichiro Mori
    Department of Medical Physics, National Institute of Radiological Sciences, Chiba, 4 9 1 Anagawa, Inage Ku, Chiba shi, Chiba, 263 8555, Japan
    AJR Am J Roentgenol 185:253-6. 2005
    ..To achieve dynamic contrast-enhanced hepatic volumetric cine imaging, we developed a prototype 256-MDCT scanner. This study examined the feasibility of the technique for human hepatic imaging in three hepatocellular carcinoma patients...
  53. doi request reprint Results of carbon ion radiotherapy for head and neck cancer
    Jun etsu Mizoe
    National Institute of Radiological Sciences, Chiba, Japan
    Radiother Oncol 103:32-7. 2012
    ..To evaluate the efficacy of carbon ion radiotherapy for head-and-neck cancer in a phase II clinical trial...
  54. ncbi request reprint MR imaging of brain injury induced by carbon ion radiotherapy for head and neck tumors
    Riwa Kishimoto
    Center Hospital, National Institute of Radiological Sciences, Chiba, Japan
    Magn Reson Med Sci 4:159-64. 2005
    ..Careful observation is recommended because cystic lesions can enlarge enough to require surgical treatment in some cases...
  55. doi request reprint Experience with carbon ion radiotherapy for WHO Grade 2 diffuse astrocytomas
    Azusa Hasegawa
    Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 83:100-6. 2012
    ..To assess outcomes of carbon ion radiotherapy for diffuse astrocytomas in adults...
  56. doi request reprint Carbon-ion beam treatment induces systemic antitumor immunity against murine squamous cell carcinoma
    Akinao Matsunaga
    Department of Gene Therapy, Chiba University Graduate School of Medicine, Chiba, Japan
    Cancer 116:3740-8. 2010
    ..However, to date, few clinical or experimental studies have investigated the effects of CIB treatment on tumor recurrence and antitumor immunity...
  57. ncbi request reprint Cyclooxygenase-2 impairs treatment effects of radiotherapy for cervical cancer by inhibition of radiation-induced apoptosis
    Hitoshi Ishikawa
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences NIRS, Chiba, Japan
    Int J Radiat Oncol Biol Phys 66:1347-55. 2006
    ..Cyclooxygenase-2 (COX-2) plays a pivotal role in regulation of radiation-induced apoptosis. The aim of this study was to analyze the relationship between COX-2 expression and postradiotherapy outcomes of patients with cervical cancer...
  58. ncbi request reprint [(11)C]methionine positron emission tomography and survival in patients with bone and soft tissue sarcomas treated by carbon ion radiotherapy
    Hong Zhang
    Department of Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan
    Clin Cancer Res 10:1764-72. 2004
    ..We evaluated whether L-[methyl-(11)C]-methionine (MET) uptake and its change after CIRT were the early survival predictors in patients with unresectable bone and soft tissue sarcomas...
  59. doi request reprint Long-term results of carbon ion radiation therapy for locally advanced or unfavorably located choroidal melanoma: usefulness of CT-based 2-port orthogonal therapy for reducing the incidence of neovascular glaucoma
    Shingo Toyama
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 86:270-6. 2013
    ..To determine the long-term results of carbon ion radiation therapy (C-ion RT) in patients with choroidal melanoma, and to assess the usefulness of CT-based 2-port irradiation in reducing the risk of neovascular glaucoma (NVG)...
  60. ncbi request reprint Biochemical failure after carbon ion radiotherapy for prostate cancer
    Jun Shimazaki
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Anticancer Res 32:3267-73. 2012
    ..Biochemical failure after radiotherapy for prostate cancer occurs infrequently, but some cases progress to a poor outcome. The aim of this study was to examine prognosis after biochemical failure...
  61. ncbi request reprint Carbon-11-methionine PET imaging of choroidal melanoma and the time course after carbon ion beam radiotherapy
    Katsumi Tamura
    Clinical Diagnosis Section, Research Center, Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba shi, Chiba ken, Japan
    Anticancer Res 29:1507-14. 2009
    ..The aim of this study was to assess the feasibility of MET-PET as an evaluation method of the therapeutic effect of carbon ion beam radiotherapy...
  62. doi request reprint A phase I/II clinical trial of preoperative short-course carbon-ion radiotherapy for patients with squamous cell carcinoma of the esophagus
    Yasunori Akutsu
    Investigators of the Working Group for Gastrointestinal Tumors, Chiba, Japan
    J Surg Oncol 105:750-5. 2012
    ..Carbon-ion radiotherapy (CIR) has been under development. We report the results of a phase I/II clinical trial of preoperative CIR for esophageal squamous cell carcinoma (ESCC)...
  63. ncbi request reprint Chemoradiation-induced expression of fibroblast growth factor-2 and laminin in patients with cervical cancer
    Miyako Nakawatari
    RadGenomics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Cancer Biol Ther 6:1780-6. 2007
    ..In addition, we sought to examine the predictive value of such changes in expression for disease failure after chemoradiotherapy...
  64. pmc Carbon ion radiotherapy for basal cell adenocarcinoma of the head and neck: preliminary report of six cases and review of the literature
    Keiichi Jingu
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Radiat Oncol 5:89. 2010
    ..Basal cell adenocarcinoma accounts for approximately 1.6% of all salivary gland neoplasms. In this report, we describe our experiences of treatment for BCAC with carbon ion radiotherapy in our institution...
  65. ncbi request reprint Outcomes of visual acuity in carbon ion radiotherapy: analysis of dose-volume histograms and prognostic factors
    Azusa Hasegawa
    Hospital, Charged Particle Research Center, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 64:396-401. 2006
    ..To analyze the tolerance dose for retention of visual acuity in patients with head-and-neck tumors treated with carbon ion radiotherapy...
  66. ncbi request reprint Radiographic pulmonary and pleural changes after carbon ion irradiation
    Hideki Nishimura
    Research Center of Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 55:861-6. 2003
    ..In the present study, we focus on posttreatment radiographic lung damage: specifically, its timing, features, and relation to dose-volume factors...
  67. ncbi request reprint Chromosomal aberrations in lymphocytes of lung cancer patients treated with carbon ions
    Ryonfa Lee
    Heavy Ion Radiobiology Research Group, National Institute of Radiological Sciences, Chiba, Japan
    J Radiat Res 45:195-9. 2004
    ....
  68. doi request reprint ADC value and diffusion tensor imaging of prostate cancer: changes in carbon-ion radiotherapy
    Yukihisa Takayama
    Biophysics Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Magn Reson Imaging 27:1331-5. 2008
    ..To assess the apparent diffusion coefficient (ADC) value and diffusion tensor image (DTI) including fractional anisotropy (FA) of the noncancerous prostate and prostate cancer before and after carbon-ion radiotherapy (CIRT)...
  69. doi request reprint A study on the prognostic evaluation of carbon ion radiotherapy for head and neck adenocarcinoma with C-11 methionine PET
    Mitsuhiko Hasebe
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba shi, Chiba, Japan
    Mol Imaging Biol 12:554-62. 2010
    ..We evaluated whether the L-methyl [11C]-methionine (MET) uptake could be an early predictor for local recurrence, metastasis, and the prognosis in patients with adenocarcinoma in the head and neck region...
  70. ncbi request reprint Long-term survival and risk of second cancers after radiotherapy for cervical cancer
    Tatsuya Ohno
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 69:740-5. 2007
    ..To evaluate the risk of second cancers after cervical cancer treated with radiotherapy for Asian populations...
  71. ncbi request reprint CD44 and Bak expression in IL-6 or TNF-alpha gene knockout mice after whole lung irradiation
    Minako Sakai
    RadGenomics Research Group, National Institute of Radiological Sciences, Inage, Chiba, Japan
    J Radiat Res 49:409-16. 2008
    ..In conclusion, the radioresistant status of IL-6 KO mice in the acute phase of alveolar damage after irradiation suggested an important role for IL-6 in radiation pneumonitis...
  72. ncbi request reprint Accelerated hyperfractionated radiotherapy for cervical cancer: multi-institutional prospective study of forum for nuclear cooperation in Asia among eight Asian countries
    Tatsuya Ohno
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 70:1522-9. 2008
    ..To evaluate the toxicity and efficacy of accelerated hyperfractionated radiotherapy (RT) for locally advanced cervical cancer...
  73. ncbi request reprint The radiation-induced cell-death signaling pathway is activated by concurrent use of cisplatin in sequential biopsy specimens from patients with cervical cancer
    Mayumi Iwakawa
    RadGenomics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
    Cancer Biol Ther 6:905-11. 2007
    ..To identify changes in gene expression related to the concurrent use of platinum compounds with radiotherapy, in the treatment of cervical cancer...
  74. ncbi request reprint Synergistic growth suppression induced in esophageal squamous cell carcinoma cells by combined treatment with docetaxel and heavy carbon-ion beam irradiation
    Hiroyuki Kitabayashi
    Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Oncol Rep 15:913-8. 2006
    ..These data suggest that heavy carbon-ion beam irradiation combined with docetaxel may be a potentially useful therapeutic strategy for locally advanced esophageal SCC...
  75. ncbi request reprint Risk factors for neovascular glaucoma after carbon ion radiotherapy of choroidal melanoma using dose-volume histogram analysis
    Naoki Hirasawa
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences NIRS, Chiba, Japan
    Int J Radiat Oncol Biol Phys 67:538-43. 2007
    ..To determine the risk factors for neovascular glaucoma (NVG) after carbon ion radiotherapy (C-ion RT) of choroidal melanoma...
  76. ncbi request reprint Efficacy and safety of carbon ion radiotherapy in bone and soft tissue sarcomas
    Tadashi Kamada
    Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, and Chiba University Graduate School of Medicine, Chiba, Japan
    J Clin Oncol 20:4466-71. 2002
    ..To evaluate the tolerance for and effectiveness of carbon ion radiotherapy in patients with unresectable bone and soft tissue sarcomas...
  77. ncbi request reprint Phosphorous-31 magnetic resonance spectroscopy of cervical cancer using transvaginal surface coil
    Takuya Morimoto
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Magn Reson Med Sci 4:197-201. 2005
    ..Results suggests that this method will be useful for assessing uterine cervical cancer...
  78. doi request reprint Effects of carbon ion beam on putative colon cancer stem cells and its comparison with X-rays
    Xing Cui
    Heavy Ion Radiobiology Research Group, Research Center for Radiation Emergency Medicine, National Institute of Radiological Sciences NIRS, Chiba, Japan
    Cancer Res 71:3676-87. 2011
    ..Taken together, carbon ion beam therapy may have an advantage over photon beam therapy by improved targeting of putative colon cancer stem-like cells...
  79. ncbi request reprint Phase I/II clinical trials of carbon ion therapy for prostate cancer
    Koichiro Akakura
    National Institute of Radiological Science, Chiba, Japan
    Prostate 58:252-8. 2004
    ..To establish heavy ion therapy techniques for the treatment of prostate cancer, phase I/II clinical trials were initiated...
  80. ncbi request reprint LOH analysis of free DNA in the plasma of patients with mucosal malignant melanoma in the head and neck
    Ryo Takagi
    Hospital, Research Center for Charged Particle Therapy, National Institute of Radiological Science, 4 9 1 Anagawa, Inage, Chiba, 263 8555, Japan
    Int J Clin Oncol 12:199-204. 2007
    ..We conducted research on the assumption that, in MMM, the detection of loss of heterozygosity (LOH) from free DNA in the circulating plasma may be of practical use in the diagnosis of recurrence and metastasis...
  81. pmc Carbon ion radiotherapy for skull base chordoma
    Jun etsu Mizoe
    Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences NIRS, Chiba, Japan
    Skull Base 19:219-24. 2009
    ..Conclusions: Preliminary results of the phase II clinical study of CIRT for skull base chordoma showed local control at 5 years at 100%, and normal tissues showed a mild reaction without any severe morbidity of important organs...
  82. ncbi request reprint [Current status and perspective of heavy ion beam therapy for patients with pelvic recurrence after primarily resected rectal cancer]
    Shigeru Yamada
    National Institute of Radiological Sciences, Research Center for Charged Particle Therapy, Inage Ku, Chiba, Japan
    Gan To Kagaku Ryoho 36:1263-6. 2009
    ..To evaluate the tolerance for and effectiveness of carbon ion radiotherapy in patients with locally recurrent rectal cancer...