Hitoshi Tsuda

Summary

Affiliation: National Defense Medical College
Country: Japan

Publications

  1. ncbi request reprint Concordance in judgments among c-erbB-2 (HER2/neu) overexpression detected by two immunohistochemical tests and gene amplification detected by Southern blot hybridization in breast carcinoma
    H Tsuda
    Pathology Division, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Pathol Int 51:26-32. 2001
  2. pmc Correlation of DNA hypomethylation at pericentromeric heterochromatin regions of chromosomes 16 and 1 with histological features and chromosomal abnormalities of human breast carcinomas
    Hitoshi Tsuda
    Pathology Division, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Am J Pathol 161:859-66. 2002
  3. ncbi request reprint Reproducible immunohistochemical criteria based on multiple raters' judgments for expression of thymidine phosphorylase in breast cancer tissue
    Hitoshi Tsuda
    Department of Pathology II, National Defense Medical College, Tokorozawa, Saitama, Japan
    Breast Cancer Res Treat 86:215-23. 2004
  4. ncbi request reprint Correlation of KIT and EGFR overexpression with invasive ductal breast carcinoma of the solid-tubular subtype, nuclear grade 3, and mesenchymal or myoepithelial differentiation
    Hitoshi Tsuda
    Department of Pathology II, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513
    Cancer Sci 96:48-53. 2005
  5. ncbi request reprint Reproducible and clinically meaningful differential diagnosis is possible between lobular endocervical glandular hyperplasia and 'adenoma malignum' based on common histopathological criteria
    Hitoshi Tsuda
    Department of Pathology II, National Defense Medical College, Tokorozawa, Japan
    Pathol Int 55:412-8. 2005
  6. ncbi request reprint Interobserver variation in the diagnosis of adenoma malignum (minimal deviation adenocarcinoma) of the uterine cervix
    Hitoshi Tsuda
    Department of Pathology II, National Defense Medical College, Tokorozawa, Saitama, Japan
    Pathol Int 53:440-9. 2003
  7. ncbi request reprint Different pattern of loss of heterozygosity among endocervical-type adenocarcinoma, endometrioid-type adenocarcinoma and adenoma malignum of the uterine cervix
    Hitoshi Tsuda
    Pathology Division, National Cancer Research Institute and Hospital, Tokyo, Japan
    Int J Cancer 98:713-7. 2002
  8. ncbi request reprint Detection of HER-2/neu (c-erb B-2) DNA amplification in primary breast carcinoma. Interobserver reproducibility and correlation with immunohistochemical HER-2 overexpression
    H Tsuda
    Department of Pathology II, National Defense Medical College, Saitama, Japan
    Cancer 92:2965-74. 2001
  9. ncbi request reprint Pattern of chromosome 16q loss differs between an atypical proliferative lesion and an intraductal or invasive ductal carcinoma occurring subsequently in the same area of the breast
    H Tsuda
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Mod Pathol 14:382-8. 2001
  10. doi request reprint Frequent inactivation of a putative tumor suppressor, angiopoietin-like protein 2, in ovarian cancer
    Ryoko Kikuchi
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Res 68:5067-75. 2008

Collaborators

Detail Information

Publications131 found, 100 shown here

  1. ncbi request reprint Concordance in judgments among c-erbB-2 (HER2/neu) overexpression detected by two immunohistochemical tests and gene amplification detected by Southern blot hybridization in breast carcinoma
    H Tsuda
    Pathology Division, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Pathol Int 51:26-32. 2001
    ..Further examination would be necessary to decide the significance of breast cancers of HercepTestTM score 2...
  2. pmc Correlation of DNA hypomethylation at pericentromeric heterochromatin regions of chromosomes 16 and 1 with histological features and chromosomal abnormalities of human breast carcinomas
    Hitoshi Tsuda
    Pathology Division, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Am J Pathol 161:859-66. 2002
    ..On the contrary, chromosome instability induced by mechanisms other than DNA hypomethylation in heterochromatin regions might cause the formation of der(16)t(1;16)/der(1;16) and less aggressive breast carcinomas...
  3. ncbi request reprint Reproducible immunohistochemical criteria based on multiple raters' judgments for expression of thymidine phosphorylase in breast cancer tissue
    Hitoshi Tsuda
    Department of Pathology II, National Defense Medical College, Tokorozawa, Saitama, Japan
    Breast Cancer Res Treat 86:215-23. 2004
    ..To accurately evaluate the TP status in breast cancer tissue, three or more raters are needed and the majority system and total scoring system appear appropriate...
  4. ncbi request reprint Correlation of KIT and EGFR overexpression with invasive ductal breast carcinoma of the solid-tubular subtype, nuclear grade 3, and mesenchymal or myoepithelial differentiation
    Hitoshi Tsuda
    Department of Pathology II, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513
    Cancer Sci 96:48-53. 2005
    ..KIT and EGFR appeared to be indicators of high-grade breast carcinoma groups that often contain the carcinomas with mesenchymal and/or myoepithelial differentiation, which are distinct from the group with c-erbB-2 overexpression...
  5. ncbi request reprint Reproducible and clinically meaningful differential diagnosis is possible between lobular endocervical glandular hyperplasia and 'adenoma malignum' based on common histopathological criteria
    Hitoshi Tsuda
    Department of Pathology II, National Defense Medical College, Tokorozawa, Japan
    Pathol Int 55:412-8. 2005
    ..01). It is clearly shown that reproducible differential diagnosis is possible between LEGH, LEGH with AIS, and MDA and that such a differentiation is clinically meaningful...
  6. ncbi request reprint Interobserver variation in the diagnosis of adenoma malignum (minimal deviation adenocarcinoma) of the uterine cervix
    Hitoshi Tsuda
    Department of Pathology II, National Defense Medical College, Tokorozawa, Saitama, Japan
    Pathol Int 53:440-9. 2003
    ....
  7. ncbi request reprint Different pattern of loss of heterozygosity among endocervical-type adenocarcinoma, endometrioid-type adenocarcinoma and adenoma malignum of the uterine cervix
    Hitoshi Tsuda
    Pathology Division, National Cancer Research Institute and Hospital, Tokyo, Japan
    Int J Cancer 98:713-7. 2002
    ..Chromosomal arms that are prone to show LOH appeared to differ between the 2 types of cervical adenocarcinoma. We could suggest that "pure" adenoma malignum is of clonal and neoplastic nature in view of the detection of LOH...
  8. ncbi request reprint Detection of HER-2/neu (c-erb B-2) DNA amplification in primary breast carcinoma. Interobserver reproducibility and correlation with immunohistochemical HER-2 overexpression
    H Tsuda
    Department of Pathology II, National Defense Medical College, Saitama, Japan
    Cancer 92:2965-74. 2001
    ..Fluorescent in situ hybridization (FISH) has been shown to be one of the most reliable methods with which to estimate the status of the HER-2/neu (or c-erb B-2) oncogene at the DNA level...
  9. ncbi request reprint Pattern of chromosome 16q loss differs between an atypical proliferative lesion and an intraductal or invasive ductal carcinoma occurring subsequently in the same area of the breast
    H Tsuda
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Mod Pathol 14:382-8. 2001
    ..Although atypical proliferative lesions were frequently confirmed to be of clonal nature with LOH on 16q, these lesions and carcinomas were considered to be clones, probably originated from a field with these clones...
  10. doi request reprint Frequent inactivation of a putative tumor suppressor, angiopoietin-like protein 2, in ovarian cancer
    Ryoko Kikuchi
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Res 68:5067-75. 2008
    ..These results suggest that, at least partly, epigenetic silencing by hypermethylation of the ANGPTL2 promoter leads to a loss of ANGPTL2 function, which may be a factor in the carcinogenesis of OC in a stage-dependent manner...
  11. doi request reprint c-MET/phospho-MET protein expression and MET gene copy number in non-small cell lung carcinomas
    Koji Tsuta
    Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan
    J Thorac Oncol 7:331-9. 2012
    ..The aim of this study was to examine the correlations between c-MET/phospho-MET expression as well as MET gene copy number alterations and overall survival (OS) in non-small cell lung carcinomas (NSCLCs)...
  12. pmc Utility of 18F-fluoro-deoxyglucose emission tomography/computed tomography fusion imaging (18F-FDG PET/CT) in combination with ultrasonography for axillary staging in primary breast cancer
    Shigeto Ueda
    Department of Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    BMC Cancer 8:165. 2008
    ....
  13. ncbi request reprint Potential crosstalk between insulin-like growth factor receptor type 1 and epidermal growth factor receptor in progression and metastasis of pancreatic cancer
    Shigeto Ueda
    Department of Surgery I, National Defense Medical College, Tokorozawa, Saitama, Japan
    Mod Pathol 19:788-96. 2006
    ..Crosstalk between differently localized IGF1R and EGFR might play a role in determining the biological aggressiveness of pancreatic cancer, although their cellular localization may often alter during the process of metastasis...
  14. doi request reprint Actinin-4 gene amplification in ovarian cancer: a candidate oncogene associated with poor patient prognosis and tumor chemoresistance
    Sohei Yamamoto
    Department of Basic Pathology, National Defense Medical College, Tokorozawa, Japan
    Mod Pathol 22:499-507. 2009
    ..The actinin-4 gene may be a target of the 19q amplicon, acting as a candidate oncogene, and serve as a predictor of poor outcome and tumor chemoresistance in patients with advanced-stage ovarian cancers...
  15. doi request reprint Clinicopathological and prognostic relevance of uptake level using 18F-fluorodeoxyglucose positron emission tomography/computed tomography fusion imaging (18F-FDG PET/CT) in primary breast cancer
    Shigeto Ueda
    Department of Basic Pathology, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Jpn J Clin Oncol 38:250-8. 2008
    ..Using integrated 18F-fluorodeoxyglucose positron emission tomography/computed tomography fusion imaging (18F-FDG PET/CT), the clinical significance of 18F-FDG uptake was evaluated in patients with primary breast cancer...
  16. doi request reprint The impact of complete surgical staging upon survival in early-stage ovarian clear cell carcinoma: a multi-institutional retrospective study
    Masashi Takano
    Department of Obstetrics and Gynecology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Int J Gynecol Cancer 19:1353-7. 2009
    ..More effective treatment modality was warranted, especially for CCC cases positive for malignant peritoneal cytology...
  17. ncbi request reprint Progression-free survival and overall survival of patients with clear cell carcinoma of the ovary treated with paclitaxel-carboplatin or irinotecan-cisplatin: retrospective analysis
    Masashi Takano
    Department of Obstetrics and Gynecology, National Defense Medical College, Namiki 3 2, Tokorozawa, Saitama, 359 8513, Japan
    Int J Clin Oncol 12:256-60. 2007
    ..Our aim was to compare progression-free survival (PFS) between patients treated with irinotecan hydrochloride and cisplatin (CPT-P) and those with treated with paclitaxel and carboplatin (TC)...
  18. doi request reprint Loss of ARID1A protein expression occurs as an early event in ovarian clear-cell carcinoma development and frequently coexists with PIK3CA mutations
    Sohei Yamamoto
    Department of Basic Pathology, National Defense Medical College, Tokorozawa, Japan
    Mod Pathol 25:615-24. 2012
    ....
  19. doi request reprint ACTN4 gene amplification and actinin-4 protein overexpression drive tumour development and histological progression in a high-grade subset of ovarian clear-cell adenocarcinomas
    Sohei Yamamoto
    Department of Basic Pathology, National Defense Medical College, Saitama, Japan
    Histopathology 60:1073-83. 2012
    ..2, enhances cell motility by bundling the actin cytoskeleton. We assessed how ACTN4/actinin-4 alterations contribute to the tumorigenesis of ovarian clear-cell adenocarcinomas (CCAs)...
  20. doi request reprint Accumulative copy number increase of MET drives tumor development and histological progression in a subset of ovarian clear-cell adenocarcinomas
    Sohei Yamamoto
    Department of Basic Pathology, National Defense Medical College, Tokorozawa, Japan
    Mod Pathol 25:122-30. 2012
    ....
  21. ncbi request reprint Analysis of sentinel node involvement in gastric cancer
    Daisaku Morita
    Department of Basic Pathology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Clin Gastroenterol Hepatol 5:1046-52. 2007
    ..Because sentinel nodes (SNs) to gastric cancer exist but they have not been well-described, we attempted to validate the SN concept at the micrometastasis level...
  22. doi request reprint Less impact of adjuvant chemotherapy for stage I clear cell carcinoma of the ovary: a retrospective Japan Clear Cell Carcinoma Study
    Masashi Takano
    Department of Obstetrics and Gynecology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Int J Gynecol Cancer 20:1506-10. 2010
    ..However, CCC often showed chemo-resistant phenotype, and the effect of adjuvant chemotherapy still remained uncertain...
  23. doi request reprint ROS1-rearranged lung cancer: a clinicopathologic and molecular study of 15 surgical cases
    Akihiko Yoshida
    Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan
    Am J Surg Pathol 37:554-62. 2013
    ..Fluorescence in situ hybridization signal patterns were unrelated to 5' fusion partner genes. All ROS1 fusion-positive tumors lacked alteration of EGFR, KRAS, HER2, ALK, and RET genes...
  24. doi request reprint Association of double-positive FOXA1 and FOXP1 immunoreactivities with favorable prognosis of tamoxifen-treated breast cancer patients
    Nobuhiro Ijichi
    Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan
    Horm Cancer 3:147-59. 2012
    ....
  25. doi request reprint Early metabolic response to neoadjuvant letrozole, measured by FDG PET/CT, is correlated with a decrease in the Ki67 labeling index in patients with hormone receptor-positive primary breast cancer: a pilot study
    Shigeto Ueda
    Department of Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama, 359 8513, Japan
    Breast Cancer 18:299-308. 2011
    ....
  26. ncbi request reprint High-level Skp2 expression in pancreatic ductal adenocarcinoma: correlation with the extent of lymph node metastasis, higher histological grade, and poorer patient outcome
    Takahiro Einama
    Department of Surgery I, National Defense Medical College, Tokorozawa, Japan
    Pancreas 32:376-81. 2006
    ..We examined the clinicopathologic significance and prognostic implication of Skp2 expression in pancreatic invasive ductal carcinoma...
  27. pmc Expression of centromere protein F (CENP-F) associated with higher FDG uptake on PET/CT, detected by cDNA microarray, predicts high-risk patients with primary breast cancer
    Shigeto Ueda
    Department of Basic Pathology, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    BMC Cancer 8:384. 2008
    ..The purpose of this study is to identify specific molecules upregulated in primary breast cancers with a high SUV and to examine their clinical significance...
  28. ncbi request reprint Clear cell adenocarcinoma associated with clear cell adenofibromatous components: a subgroup of ovarian clear cell adenocarcinoma with distinct clinicopathologic characteristics
    Sohei Yamamoto
    Department of Basic Pathology, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Am J Surg Pathol 31:999-1006. 2007
    ..These results suggest that CCAF besides endometriosis is associated with the development of CCA, and that the CCAF(+) group may be a distinct subgroup of CCA with less aggressive biologic behavior...
  29. ncbi request reprint Usefulness and limitation of multiple endoscopic biopsy sampling for epidermal growth factor receptor and c-erbB-2 testing in patients with gastric adenocarcinoma
    Mikihiko Kimura
    Department of Pathology II, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Jpn J Clin Oncol 35:324-31. 2005
    ..Our objective was to examine the utility of endoscopic biopsy specimens in judging the status of epidermal growth factor receptor (EGFR) and c-erbB-2 genes and proteins in the entire tumor...
  30. ncbi request reprint Alternative tyrosine phosphorylation of signaling kinases according to hormone receptor status in breast cancer overexpressing the insulin-like growth factor receptor type 1
    Shigeto Ueda
    Department of Surgery I, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Cancer Sci 97:597-604. 2006
    ..Taken together, these findings suggest that IGF1R overexpression might activate pERK1/2 and pAKT in hormone receptor-positive breast cancer, but activate only pAKT in hormone receptor-negative breast cancer...
  31. doi request reprint Prognostic significance of mitotic figures in metastatic mammary ductal carcinoma to the lymph nodes
    Takahiro Hasebe
    Pathology Consultation Service, Clinical Trials and Practice Support Division, Center for Cancer Control and Information Services, National Cancer Center, Chuo Ku, 104 0045, Tokyo, Japan
    Hum Pathol 42:1823-32. 2011
    ..In conclusion, this study clearly confirmed the excellent outcome predictive power of the number of mitotic figures in metastatic mammary carcinoma to the lymph nodes...
  32. doi request reprint Clinical implications of occult metastases and isolated tumor cells in sentinel and non-sentinel lymph nodes in early breast cancer patients: serial step section analysis with long-term follow-up
    Takashi Takeshita
    Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
    Ann Surg Oncol 19:1160-6. 2012
    ..This study was designed to clarify retrospectively the clinical significance of occult metastases in both sentinel lymph nodes (SLNs) and non-SLNs in patients with early breast cancer...
  33. ncbi request reprint The proposed factor structure of temperament and personality in Japan: combining traits from TEMPS-A and MPT
    Tsuyoshi Akiyama
    Department of Neuropsychiatry, Kanto Medical Center NTT EC, Tokyo, Japan
    J Affect Disord 85:93-100. 2005
    ..This research investigates the construct validity of these temperaments through factor analysis...
  34. doi request reprint Cumulative alterations of p27-related cell-cycle regulators in the development of endometriosis-associated ovarian clear cell adenocarcinoma
    Sohei Yamamoto
    Department of Basic Pathology, National Defence Medical College, Tokorozawa, Saitama, Japan
    Histopathology 56:740-9. 2010
    ..To identify the key cell-cycle dysregulations in the development of endometriosis-associated ovarian clear cell adenocarcinoma (CCA)...
  35. ncbi request reprint Survival analysis of ovarian clear cell carcinoma confined to the ovary with or without comprehensive surgical staging
    Masashi Takano
    Department of Obstetrics and Gynecology, National Defense Medical College, Saitama 359 8513, Japan
    Oncol Rep 19:1259-64. 2008
    ..03) and that the chemotherapeutic regimen was not a prognostic factor (p=0.43). The present study indicates that we should accomplish complete surgical staging procedures for CCC confined to the ovary...
  36. doi request reprint Identification of PAK4 as a putative target gene for amplification within 19q13.12-q13.2 in oral squamous-cell carcinoma
    Asma Begum
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Sci 100:1908-16. 2009
    ..These findings reveal that the PAK4 overexpression through amplification or other mechanisms promotes the proliferation and/or survival of OSCC cells, and that PAK4 might be a good diagnostic and/or therapeutic target...
  37. doi request reprint Comprehensive histologic analysis of ALK-rearranged lung carcinomas
    Akihiko Yoshida
    Pathology and Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan
    Am J Surg Pathol 35:1226-34. 2011
    ..ALK-positive cancers commonly showed coexpression of thyroid transcription factor-1 and p63, and its significance is currently unclear...
  38. doi request reprint Clear cell adenocarcinoma with a component of poorly differentiated histology: a poor prognostic subgroup of ovarian clear cell adenocarcinoma
    Sohei Yamamoto
    Department of Basic Pathology, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama, Japan
    Int J Gynecol Pathol 30:431-41. 2011
    ..On the basis of the prognostic impact and interobserver reproducibility, the present binary classification system for CCAs was deemed to be highly superior to the compared conventional histologic grading system...
  39. ncbi request reprint Expression of platelet-derived growth factors and their receptors in ovarian clear-cell carcinoma and its putative precursors
    Sohei Yamamoto
    Department of Basic Pathology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Mod Pathol 21:115-24. 2008
    ....
  40. doi request reprint Frequent GNAS and KRAS mutations in pyloric gland adenoma of the stomach and duodenum
    Akiko Matsubara
    Pathology and Clinical Laboratories, National Cancer Centre Hospital, Tokyo, Japan
    J Pathol 229:579-87. 2013
    ..In particular, the present study identified the frequent presence of activating GNAS mutations, which are often associated with KRAS mutations, as a characteristic genetic feature of PGAs of the stomach and duodenum...
  41. doi request reprint 18F-fluorodeoxyglucose positron emission tomography optimizes neoadjuvant chemotherapy for primary breast cancer to achieve pathological complete response
    Shigeto Ueda
    Medical Service School, National Defense Force, 1 2 24 Ikejiri, Setagaya Ku, Tokyo, 154 0001, Japan
    Int J Clin Oncol 17:276-82. 2012
    ..To assess the usefulness of positron emission tomography combined with computed tomography using (18)F-fluorodeoxyglucose (FDG PET/CT) for optimizing chemotherapy during neoadjuvant chemotherapy for primary breast cancer...
  42. doi request reprint Prognostic impact of pleural invasion in 1488 patients with surgically resected non-small cell lung carcinoma
    Mayumi Oyama
    Department of Pathology and Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan
    Jpn J Clin Oncol 43:540-6. 2013
    ..This study aimed to verify the prognostic impact of pleural invasion according to the revised TNM classification, seventh edition...
  43. doi request reprint The prognostic value of pfetin: a validation study in gastrointestinal stromal tumors using a commercially available antibody
    Daisuke Kubota
    Division of Pharmacoproteomics, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 43:669-75. 2013
    ..In the present study, we examine the usefulness of a commercially available polyclonal antibody against pfetin...
  44. doi request reprint Proteomic-based identification of the APC-binding protein EB1 as a candidate of novel tissue biomarker and therapeutic target for colorectal cancer
    Yutaka Sugihara
    Division of Pharmacoproteomics, National Cancer Center Research Institute, Japan
    J Proteomics 75:5342-55. 2012
    ..The present findings indicate that EB1 is a potential biomarker and therapeutic target in CRC...
  45. doi request reprint Aberrant expression of p27(Kip1)-interacting cell-cycle regulatory proteins in ovarian clear cell carcinomas and their precursors with special consideration of two distinct multistage clear cell carcinogenetic pathways
    Sohei Yamamoto
    Department of Basic Pathology, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama, 359 8513, Japan
    Virchows Arch 455:413-22. 2009
    ....
  46. doi request reprint Well-differentiated liposarcoma with low-grade osteosarcomatous component: an underrecognized variant
    Akihiko Yoshida
    Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan
    Am J Surg Pathol 34:1361-6. 2010
    ....
  47. doi request reprint Important histologic outcome predictors for patients with invasive ductal carcinoma of the breast
    Takahiro Hasebe
    Pathology Consultation Service, Clinical Trials and Practice Support Division, Center for Cancer Control and Information Services, National Cancer Center Hospital, Tokyo, Japan
    Am J Surg Pathol 35:1484-97. 2011
    ..These findings strongly suggest that these histologic factors are very useful for accurately predicting the outcomes of patients with invasive ductal carcinoma of the breast...
  48. doi request reprint Atypical tumor-stromal fibroblasts in invasive ductal carcinomas of the breast treated with neoadjuvant therapy
    Takahiro Hasebe
    Clinical Trials and Practice Support Division, Pathology Consultation Service, Center for Cancer Control and Information Services, National Cancer Center, Tokyo, 104 0045, Japan
    Hum Pathol 42:998-1006. 2011
    ....
  49. doi request reprint Anaplastic lymphoma kinase status in rhabdomyosarcomas
    Akihiko Yoshida
    Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan
    Mod Pathol 26:772-81. 2013
    ....
  50. doi request reprint Allelotyping analysis suggesting a consecutive progression from intratubular germ cell neoplasia to seminoma and then to embryonal carcinoma of the adult testis
    Kosuke Miyai
    Department of Basic Pathology, National Defense Medical College, Tokorozawa, Saitama 359 8513, Japan Electronic address
    Hum Pathol 44:2312-22. 2013
    ..These findings suggest that a consecutive progression from IGCNU to seminoma, and ultimately, to embryonal carcinoma mainly occurred in the testicular germ cell tumor cases. ..
  51. doi request reprint Cathepsin D as a potential prognostic marker for lung adenocarcinoma
    Takahiro Mimae
    Pathology and Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan
    Pathol Res Pract 208:534-40. 2012
    ..Cathepsin D expression is indicated to be a possible prognostic marker for lung AD and to correlate with a more poorly differentiated form...
  52. doi request reprint MDM2 and CDK4 immunohistochemical coexpression in high-grade osteosarcoma: correlation with a dedifferentiated subtype
    Akihiko Yoshida
    Departments of Pathology and Clinical Laboratories, National Cancer Center Research Institute, Tokyo, Japan
    Am J Surg Pathol 36:423-31. 2012
    ....
  53. doi request reprint Association between frequent CpG island methylation and HER2 amplification in human breast cancers
    Kotoe Terada
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Carcinogenesis 30:466-71. 2009
    ..001). These showed that frequent methylation had a strong association with HER2 amplification in breast cancers and suggested that frequent methylation can be a determinant of various characteristics in a fraction of human breast cancers...
  54. doi request reprint Clinicopathological analyses of triple negative breast cancer using surveillance data from the Registration Committee of the Japanese Breast Cancer Society
    Hirotaka Iwase
    Member of the Research Group, Japanese Breast Cancer Society, Tokyo, Japan
    Breast Cancer 17:118-24. 2010
    ..To clarify the characteristics of TN breast cancer, surveillance data of the Registration Committee of the Japanese Breast Cancer Society were analyzed...
  55. ncbi request reprint Frequent KIT and epidermal growth factor receptor overexpressions in undifferentiated-type breast carcinomas with 'stem-cell-like' features
    Hitoshi Tsuda
    Department of Pathology II, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Cancer Sci 96:333-9. 2005
    ..0002). The undifferentiated-type breast carcinomas appeared to show mammary epithelial stem cell-like features, and they could be identified by KIT and/or EGFR overexpressions...
  56. doi request reprint Expression pattern of stromal cell-derived factor-1 chemokine in invasive breast cancer is correlated with estrogen receptor status and patient prognosis
    Takayuki Kobayashi
    Department of Basic Pathology, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama, 359 8513, Japan
    Breast Cancer Res Treat 123:733-45. 2010
    ..046). SDF-1 status is a significant prognostic factor and may be clinically useful for assigning adjuvant therapy to patients with ER-positive invasive breast cancers...
  57. doi request reprint Gene amplification and protein overexpression of MET are common events in ovarian clear-cell adenocarcinoma: their roles in tumor progression and prognostication of the patient
    Sohei Yamamoto
    Department of Basic Pathology, National Defense Medical College, Saitama, Japan
    Mod Pathol 24:1146-55. 2011
    ..MET could serve as a biomarker for the prognostication of patients with clear-cell adenocarcinoma and tumor progression, and has potential as a novel therapeutic target for this carcinoma...
  58. doi request reprint Validation of the histologic grading for ovarian clear cell adenocarcinoma: a retrospective multi-institutional study by the Japan Clear Cell Carcinoma Study Group
    Sohei Yamamoto
    Department of Basic Pathology, National Defense Medical College, Ohki Memorial Kikuchi Cancer Clinic for Women, Tokorozawa, Saitama, Japan
    Int J Gynecol Pathol 30:129-38. 2011
    ..These results suggest that the 2 tested grading systems have limited value for the prognostication of patients with clear cell adenocarcinoma, and that a more effective grading system for this tumor may be required...
  59. ncbi request reprint Prognostic implication of laminin-5 gamma 2 chain expression in the invasive front of colorectal cancers, disclosed by area-specific four-point tissue microarrays
    Eiji Shinto
    Department of Pathology II, National Defense Medical College, Tokorozawa, Japan
    Lab Invest 85:257-66. 2005
    ..Analysis using area-specific four-point TMAs clearly demonstrated that LN-5gamma2 expression in the invasive front largely influences the degree of clinical aggressiveness of CRC and its tendency to metastasize...
  60. doi request reprint Follow-up data of 10 patients with B-cell non-Hodgkin lymphoma with a CD20-negative phenotypic change after rituximab-containing therapy
    Akiko M Maeshima
    Department of Pathology and Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan
    Am J Surg Pathol 37:563-70. 2013
    ..As the changes in morphology and CD20 expression after rituximab therapy vary widely, careful follow-up and rebiopsy are recommended...
  61. doi request reprint Laser microdissection and two-dimensional difference gel electrophoresis reveal proteomic intra-tumor heterogeneity in colorectal cancer
    Yutaka Sugihara
    Division of Pharmacoproteomics, National Cancer Center Research Institute, Tokyo, Japan
    J Proteomics 78:134-47. 2013
    ....
  62. doi request reprint Histological grading of ovarian clear cell adenocarcinoma: proposal for a simple and reproducible grouping system based on tumor growth architecture
    Sohei Yamamoto
    Department of Basic Pathology, National Defense Medical College, Japan
    Int J Gynecol Pathol 31:116-24. 2012
    ..The proposed grouping system could divide patients with CCA into 3 subgroups with distinct prognostic indications, providing a 3-tier histological grading system for ovarian CCA...
  63. doi request reprint Genetic clustering of clear cell renal cell carcinoma based on array-comparative genomic hybridization: its association with DNA methylation alteration and patient outcome
    Eri Arai
    Pathology Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Clin Cancer Res 14:5531-9. 2008
    ..The aim of this study was to clarify genetic and epigenetic alterations occurring during renal carcinogenesis...
  64. ncbi request reprint Clinicopathologic and technical factors associated with the uptake of radiocolloid by sentinel nodes in patients with breast cancer
    Kazuhiko Sato
    Department of Surgery I, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Surg Today 33:403-7. 2003
    ..The aim of this study was to identify the factors associated with the colloidal uptake of the sentinel nodes...
  65. ncbi request reprint BCL2L2 is a probable target for novel 14q11.2 amplification detected in a non-small cell lung cancer cell line
    Tsutomu Kawasaki
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo, Japan
    Cancer Sci 98:1070-7. 2007
    ..These findings demonstrate that overexpressed BCL2L2, through amplification or other mechanisms, promotes the growth of NSCLC, especially the adenocarcinoma subtype, and might be a therapeutic target...
  66. ncbi request reprint Reduced expression of GNA11 and silencing of MCT1 in human breast cancers
    Kiyoshi Asada
    Division of Carcinogenesis, National Cancer Center Research Institute, Tokyo, Japan
    Oncology 64:380-8. 2003
    ..MCT1 is involved in cellular transportation of butyrate, which induces cellular differentiation. Downregulation of these two genes was suggested to be involved in human breast cancers...
  67. doi request reprint NKX2.2 is a useful immunohistochemical marker for Ewing sarcoma
    Akihiko Yoshida
    Pathology and Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan
    Am J Surg Pathol 36:993-9. 2012
    ..All the other non-Ewing tumors tested were negative for this marker. NKX2.2 is a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors...
  68. doi request reprint Validation study on pfetin and ATP-dependent RNA helicase DDX39 as prognostic biomarkers in gastrointestinal stromal tumour
    Daisuke Kubota
    Division of Pharmacoproteomics, National Cancer Center Research Institute, Tokyo, Japan
    Jpn J Clin Oncol 42:730-41. 2012
    ..Prognostic biomarkers have long been required for the optimal use of kinase inhibitors in gastrointestinal stromal tumour...
  69. doi request reprint Immunohistochemical detection of breast cancer stem cells in hormone receptor-positive breast cancer and their role in response to endocrine therapy and clinical outcome
    Kenji Hashimoto
    Department of Breast Oncology and Medical Oncology, National Cancer Center Hospital, Tokyo, Japan
    Oncology 82:168-74. 2012
    ..Therefore, we launched this retrospective biomarker analysis to clarify the role of stem cells in relation with endocrine therapy in hormone receptor-positive breast cancer...
  70. doi request reprint Clinical proteomics identified ATP-dependent RNA helicase DDX39 as a novel biomarker to predict poor prognosis of patients with gastrointestinal stromal tumor
    Kazutaka Kikuta
    Division of Pharmacoproteomics, National Cancer Center Research Institute, Japan
    J Proteomics 75:1089-98. 2012
    ..ATP-dependent RNA helicase DDX39, a novel biomarker for GIST likely to be associated with metastatic disease, can identify patients likely to benefit from new therapeutic strategies such as tyrosine kinase inhibitors...
  71. doi request reprint PIK3CA mutations and loss of ARID1A protein expression are early events in the development of cystic ovarian clear cell adenocarcinoma
    Sohei Yamamoto
    Department of Basic Pathology, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama, Japan
    Virchows Arch 460:77-87. 2012
    ..013). PIK3CA gene mutations and ARID1A immunohistochemistry lacked prognostic significance. These data further support the idea that these molecular alterations occur as very early events during tumor development of ovarian CCA...
  72. doi request reprint Atypical tumor-stromal fibroblasts in invasive ductal carcinoma of the breast
    Takahiro Hasebe
    Clinical Trials and Practice Support Division, Pathology Consultation Service, Center for Cancer Control and Information Services, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Am J Surg Pathol 35:325-36. 2011
    ....
  73. ncbi request reprint Differential prognostic significance of morphologic invasive markers in colorectal cancer: tumor budding and cytoplasmic podia
    Eiji Shinto
    Department of Pathology II, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Dis Colon Rectum 49:1422-30. 2006
    ..In this study, we have investigated the prognostic significance of cytoplasmic podia...
  74. doi request reprint An allelotype analysis indicating the presence of two distinct ovarian clear-cell carcinogenic pathways: endometriosis-associated pathway vs. clear-cell adenofibroma-associated pathway
    Sohei Yamamoto
    Department of Basic Pathology, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama, 359 8513, Japan
    Virchows Arch 455:261-70. 2009
    ..These data further support the presence of two distinct carcinogenic pathways to ovarian clear-cell adenocarcinoma; the allelic status of the 3p, 5q, and 11q loci may provide a means to identify the precursor lesions of these carcinomas...
  75. ncbi request reprint The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: poor prognosis in patients with pancreatic ductal adenocarcinoma
    Shigeto Ueda
    Surgery I, National Defense Medical College, Saitama, Japan
    Pancreas 29:e1-8. 2004
    ..We examined the clinicopathological significance of the expression and localization of EGFr and HER-2 in both invasive and intraductal components of ductal adenocarcinomas of the pancreas...
  76. ncbi request reprint Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization
    Hisashi Takada
    Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima Bunkyo ku, Tokyo, 113 8510, Japan
    Cancer Sci 96:100-10. 2005
    ..Taken together, our data indicate that CDK6 might be involved in the pathogenesis of GC and, more generally, that CGH-arrays have a powerful potential for identifying novel cancer-related genetic changes in a variety of tumors...
  77. doi request reprint Protein overexpression and gene amplification of epidermal growth factor receptor in adult testicular germ cell tumors: potential role in tumor progression
    Kosuke Miyai
    Department of Basic Pathology, Tokorozawa, Saitama, Japan
    Cancer Sci 101:1970-6. 2010
    ....
  78. doi request reprint A histopathological study for evaluation of therapeutic effects of radiofrequency ablation in patients with breast cancer
    Hitoshi Tsuda
    Pathology and Clinical Laboratory Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo, Japan
    Breast Cancer 18:24-32. 2011
    ..To reveal the rate of complete therapeutic effect of radiofrequency ablation (RFA) and its correlation with tumor size by the histopathological examination of surgically resected early breast cancers...
  79. doi request reprint Malignant pulmonary epithelioid hemangioendothelioma with hilar lymph node metastasis
    Naobumi Tochigi
    Pathology Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Ann Diagn Pathol 15:207-12. 2011
    ....
  80. doi request reprint Utility of 10 immunohistochemical markers including novel markers (desmocollin-3, glypican 3, S100A2, S100A7, and Sox-2) for differential diagnosis of squamous cell carcinoma from adenocarcinoma of the Lung
    Koji Tsuta
    Division of Pathology and Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan
    J Thorac Oncol 6:1190-9. 2011
    ..Recent clinical trials revealed that accurate histologic typing of non-small cell lung cancer, especially squamous cell carcinoma (SCC), is essential...
  81. ncbi request reprint Actinin-4 expression in ovarian cancer: a novel prognostic indicator independent of clinical stage and histological type
    Sohei Yamamoto
    Department of Basic Pathology, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama, Japan
    Mod Pathol 20:1278-85. 2007
    ..Accumulation of actinin-4 in the cytoplasm may be related to a higher propensity for tumor invasiveness and metastasis, probably by enhancing cell motility, and could be a novel prognostic indicator for patients with ovarian carcinomas...
  82. ncbi request reprint Utility of axillary ultrasound examination to select breast cancer patients suited for optimal sentinel node biopsy
    Kazuhiko Sato
    Department of Surgery I, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Am J Surg 187:679-83. 2004
    ..Because sentinel node (SN) biopsy (SNB) is known to produce false-negative results, we examined the usefulness of axillary ultrasound (AUS) in selecting patients suitable for optimal SNB...
  83. ncbi request reprint Different expression patterns of KIT, EGFR, and HER-2 (c-erbB-2) oncoproteins between epithelial and mesenchymal components in uterine carcinosarcoma
    Morio Sawada
    Department of Gynecology, National Cancer Center Hospital, Tokyo, and Department of Pathology II, National Defense Medical College, Tokorozawa
    Cancer Sci 94:986-91. 2003
    ..Structural and/or numerical alterations of chromosomes might be in part involved in EGFR and/or HER-2 overexpression in this tumor type...
  84. ncbi request reprint Multicenter phase II trial of neoadjuvant exemestane for postmenopausal patients with hormone receptor-positive, operable breast cancer: Saitama Breast Cancer Clinical Study Group (SBCCSG-03)
    Hiroyuki Takei
    Division of Breast Surgery, Saitama Cancer Center, Kita adachi, Saitama, Japan
    Breast Cancer Res Treat 107:87-94. 2008
    ..Further studies are required to determine the optimal duration of neoadjuvant treatment and to identify response criteria that can more accurately predict long-term outcomes...
  85. ncbi request reprint Clinicopathological significance of WT1 expression in ovarian cancer: a possible accelerator of tumor progression in serous adenocarcinoma
    Sohei Yamamoto
    Department of Basic Pathology, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Virchows Arch 451:27-35. 2007
    ..003), Ki-67 LI (P = 0.012), Bcl-2 expression (P = 0.003), and poorer patient outcome (5-year survival, 36.5 vs 63.8%, P = 0.008 by log-rank test). The WT1 protein may be an accelerator of the progression of OSA...
  86. ncbi request reprint ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation
    Hisashi Takada
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    Oncogene 24:8051-60. 2005
    ..These results suggest that genetic or epigenetic silencing by hypermethylation of the ADAM23 CpG-rich promoter region leads to loss of ADAM23 function, which may be a factor in gastric carcinogenesis...
  87. doi request reprint Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas
    Satoru Kikuchi
    Chemotherapy Division, Cancer Proteomics Project, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Clin Cancer Res 14:5348-56. 2008
    ..Actinin-4 is an actin-binding protein associated with enhanced cell motility, invasive growth, and lymph node metastasis. Actinin-4 might play an important role in the development and progression of pancreatic cancer...
  88. ncbi request reprint Nuclear expression of cIAP-1, an apoptosis inhibiting protein, predicts lymph node metastasis and poor patient prognosis in head and neck squamous cell carcinomas
    Takao Tanimoto
    Department of Pathology II, National Defense Medical College, Tokorozawa, Saitama, Japan
    Cancer Lett 224:141-51. 2005
    ..Nuclear cIAP-1 expression appears to be a useful marker for predicting poor patient prognosis in HNSCCs, and may play roles in HNSCCs through the signaling pathway mediated by Smac/DIABLO and caspase-3...
  89. doi request reprint PIK3CA mutation is an early event in the development of endometriosis-associated ovarian clear cell adenocarcinoma
    Sohei Yamamoto
    Department of Basic Pathology, National Defence Medical College, 3 2 Namiki, Tokorozawa, Saitama, Japan
    J Pathol 225:189-94. 2011
    ..A specific kinase inhibitor to mutated PIK3CA may potentially be an effective therapeutic reagent against these carcinomas...
  90. ncbi request reprint Adjuvant chemotherapy with irinotecan hydrochloride and cisplatin for clear cell carcinoma of the ovary
    Masashi Takano
    Department of Obstetrics and Gynecology, National Defense Medical College, Saitama 359 8513, Japan
    Oncol Rep 16:1301-6. 2006
    ..However, this is a limited retrospective study, therefore we recommend that the CPT-P regimen be evaluated in a larger prospective study...
  91. ncbi request reprint Invasive ductal carcinoma associated with tubular adenoma of the breast
    Hideharu Domoto
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Pathol Int 52:244-8. 2002
    ..Both the long-term observation of this case and analysis of more cases may enable us to determine the histological characteristics and clinical significance of invasive ductal carcinoma associated with tubular adenoma...
  92. doi request reprint Clinicopathologic analysis of multiple (five or more) atypical adenomatous hyperplasias (AAHs) of the lung: evidence for the AAH-adenocarcinoma sequence
    Akiko Miyagi Maeshima
    Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan
    J Thorac Oncol 5:466-71. 2010
    ..Clarification of the clinicopathologic characteristics of patients with multiple atypical adenomatous hyperplasias (AAHs)...
  93. doi request reprint Prognostic significance of expression of CCL5/RANTES receptors in patients with gastric cancer
    Hidekazu Sugasawa
    Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
    J Surg Oncol 97:445-50. 2008
    ..The clinical significance of CCL5 has been reported in several malignancies. In this study, we examined the prognostic impact of serum CCL5 levels and the expression of CCL5 receptors on tumor cells in patients with gastric cancer...
  94. ncbi request reprint Photoacoustic diagnosis of burns in rats
    Shunichi Sato
    Division of Biomedical Information Sciences, National Defense Medical College Research Institute, National Defense Medical College, Tokorozawa, Japan
    J Trauma 59:1450-5; discussion 1455-6. 2005
    ..In this study, we investigated the validity of this method by an experiment using rat scald burn models...
  95. doi request reprint Individualization of breast cancer based on histopathological features and molecular alterations
    Hitoshi Tsuda
    Department of Basic Pathology, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama, 359 8513, Japan
    Breast Cancer 15:121-32. 2008
    ..It is expected that additional molecular markers and novel diagnostic tools will be developed in the future to facilitate a more accurate characterization of higher risk node-negative breast carcinomas...
  96. ncbi request reprint Invasive ductal carcinoma of the breast with a large central acellular zone associated with matrix-producing carcinoma
    Yukihiro Hama
    Department of Radiology, National Defense Medical College, Namiki, Tokorozawa, Saitama, Japan
    Tumori 90:498-500. 2004
    ....
  97. ncbi request reprint HER-2 (c-erbB-2) test update: present status and problems
    Hitoshi Tsuda
    Department of Pathology II, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Breast Cancer 13:236-48. 2006
    ..These tests should be performed in strict adherence to existing instructions. Quality control is of utmost importance when performing HER-2 tests, both internal and external, for routine diagnosis and in clinical protocol studies...
  98. ncbi request reprint Evaluation of interobserver agreement in scoring immunohistochemical results of HER-2/neu (c-erbB-2) expression detected by HercepTest, Nichirei polyclonal antibody, CB11 and TAB250 in breast carcinoma
    Hitoshi Tsuda
    Second Department of Pathology, National Defense Medical College, Tokorozawa, Japan
    Pathol Int 52:126-34. 2002
    ..When cases of score 2+ are entered into a protocol, evaluation should be given by multiple observers and/or by using other tests such as fluorescence in situ hybridization...
  99. ncbi request reprint Effect of HER-2/neu overexpression on chemoresistance and prognosis in ovarian carcinoma
    Naoki Sasaki
    Department of Gynecology and Obstetrics, National Defense Medical College, Saitama, Japan
    J Obstet Gynaecol Res 33:17-23. 2007
    ..To investigate the effect of HER-2/neu protein overexpression on chemoresistance and prognosis in patients with epithelial ovarian carcinoma...
  100. ncbi request reprint A proposal for diagnostically meaningful criteria to classify increased epidermal growth factor receptor and c-erbB-2 gene copy numbers in gastric carcinoma, based on correlation of fluorescence in situ hybridization and immunohistochemical measurements
    Mikihiko Kimura
    Department of Pathology II, National Defense Medical College, 3 2 Namiki, Tokorozawa, 359 8513 Saitama, Japan
    Virchows Arch 445:255-62. 2004
    ..7 and a mean c-erbB-2 gene copy number of 7.0 or more and/or a c-erbB-2/CEP17 ratio of 2.0 or more would be useful in defining increased EGFR and c-erbB-2 gene copy numbers, respectively, in gastric carcinomas...
  101. doi request reprint p53 expression in tumor-stromal fibroblasts forming and not forming fibrotic foci in invasive ductal carcinoma of the breast
    Takahiro Hasebe
    Pathology Consultation Service, Clinical Trials and Practice Support Division, Center for Cancer Control and Information Service, National Cancer Center, Chuo Ku, Tokyo, Japan
    Mod Pathol 23:662-72. 2010
    ....