H Tsuda

Summary

Affiliation: National Cancer Center
Country: Japan

Publications

  1. ncbi request reprint Value of GST-P positive preneoplastic hepatic foci in dose-response studies of hepatocarcinogenesis: evidence for practical thresholds with both genotoxic and nongenotoxic carcinogens. A review of recent work
    Hiroyuki Tsuda
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Toxicol Pathol 31:80-6. 2003
  2. ncbi request reprint Prevention of colon carcinogenesis and carcinoma metastasis by orally administered bovine lactoferrin in animals
    H Tsuda
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Biofactors 12:83-8. 2000
  3. ncbi request reprint Cancer prevention by bovine lactoferrin and underlying mechanisms--a review of experimental and clinical studies
    Hiroyuki Tsuda
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Biochem Cell Biol 80:131-6. 2002
  4. ncbi request reprint Milk and dairy products in cancer prevention: focus on bovine lactoferrin
    H Tsuda
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tsukiji 5 1 1, Chuo Ku, Tokyo, Japan
    Mutat Res 462:227-33. 2000
  5. ncbi request reprint Carcinogenesis and its modification by environmental endocrine disruptors: in vivo experimental and epidemiological findings
    Hiroyuki Tsuda
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Jpn J Clin Oncol 33:259-70. 2003
  6. ncbi request reprint Mammary carcinomas induced in human c-Ha-ras proto-oncogene transgenic rats are estrogen-independent, but responsive to d-limonene treatment
    Makoto Asamoto
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Cancer Res 93:32-5. 2002
  7. ncbi request reprint High susceptibility of transgenic rats carrying the human c-Ha-ras proto-oncogene to chemically-induced mammary carcinogenesis
    H Tsuda
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, 104 0045, Tokyo, Japan
    Mutat Res 477:173-82. 2001
  8. ncbi request reprint Orally administered lactoferrin exerts an antimetastatic effect and enhances production of IL-18 in the intestinal epithelium
    T Kuhara
    Experimental Pathology and Chemotherapy Division, National Cancer Research Institute, Tokyo, Japan
    Nutr Cancer 38:192-9. 2000
  9. ncbi request reprint Accuracy of contrast-enhanced computed tomography in the prediction of residual breast cancer after neoadjuvant chemotherapy
    S Akashi-Tanaka
    Division of Surgical Oncology, National Cancer Center Hospital, Tokyo, Japan
    Int J Cancer 96:66-73. 2001
  10. ncbi request reprint Distinct outcome of stage I lung adenocarcinoma with ACTN4 cell motility gene amplification
    R Noro
    Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo
    Ann Oncol 24:2594-600. 2013

Collaborators

Detail Information

Publications123 found, 100 shown here

  1. ncbi request reprint Value of GST-P positive preneoplastic hepatic foci in dose-response studies of hepatocarcinogenesis: evidence for practical thresholds with both genotoxic and nongenotoxic carcinogens. A review of recent work
    Hiroyuki Tsuda
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Toxicol Pathol 31:80-6. 2003
    ....
  2. ncbi request reprint Prevention of colon carcinogenesis and carcinoma metastasis by orally administered bovine lactoferrin in animals
    H Tsuda
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Biofactors 12:83-8. 2000
    ..Results of those experiments indicate that bLF remarkably prevents colon carcinogenesis and lung metastasis of colon carcinoma cells, possibly due to increasing cytotoxic cells in the peripheral blood...
  3. ncbi request reprint Cancer prevention by bovine lactoferrin and underlying mechanisms--a review of experimental and clinical studies
    Hiroyuki Tsuda
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Biochem Cell Biol 80:131-6. 2002
    ..More extensive clinical trials are now underway in the National Cancer Center Hospital and other institutes to further explore the preventive potential against colon carcinogenesis...
  4. ncbi request reprint Milk and dairy products in cancer prevention: focus on bovine lactoferrin
    H Tsuda
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tsukiji 5 1 1, Chuo Ku, Tokyo, Japan
    Mutat Res 462:227-33. 2000
    ..01 and P<0.05, respectively). Results in other animal models have provided further indications that bLF might find application as a natural ingredient of milk with potential for chemoprevention of colon and other cancers...
  5. ncbi request reprint Carcinogenesis and its modification by environmental endocrine disruptors: in vivo experimental and epidemiological findings
    Hiroyuki Tsuda
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Jpn J Clin Oncol 33:259-70. 2003
    ..Thus, careful in vivo assessment is required before drawing any conclusions regarding agents capable of affecting the mammalian endocrine system...
  6. ncbi request reprint Mammary carcinomas induced in human c-Ha-ras proto-oncogene transgenic rats are estrogen-independent, but responsive to d-limonene treatment
    Makoto Asamoto
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Cancer Res 93:32-5. 2002
    ..These results indicate that aberrant c-Ha-ras gene expression is involved in ovarian hormone-independent growth and c-Ha-ras protein isoprenylation plays an important role in mammary carcinogenesis...
  7. ncbi request reprint High susceptibility of transgenic rats carrying the human c-Ha-ras proto-oncogene to chemically-induced mammary carcinogenesis
    H Tsuda
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, 104 0045, Tokyo, Japan
    Mutat Res 477:173-82. 2001
    ..Furthermore, irrespective of the mechanism of enhanced susceptibility, the Hras128 transgenic rats can be utilized for the screening of mammary carcinogens...
  8. ncbi request reprint Orally administered lactoferrin exerts an antimetastatic effect and enhances production of IL-18 in the intestinal epithelium
    T Kuhara
    Experimental Pathology and Chemotherapy Division, National Cancer Research Institute, Tokyo, Japan
    Nutr Cancer 38:192-9. 2000
    ....
  9. ncbi request reprint Accuracy of contrast-enhanced computed tomography in the prediction of residual breast cancer after neoadjuvant chemotherapy
    S Akashi-Tanaka
    Division of Surgical Oncology, National Cancer Center Hospital, Tokyo, Japan
    Int J Cancer 96:66-73. 2001
    ..In conclusion, CE-CT is the most accurate noninvasive technique for identifying the extent of the residual carcinoma after neoadjuvant chemotherapy if cases of IBC and ILC are excluded...
  10. ncbi request reprint Distinct outcome of stage I lung adenocarcinoma with ACTN4 cell motility gene amplification
    R Noro
    Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo
    Ann Oncol 24:2594-600. 2013
    ..Even if detected at an early stage, a substantial number of lung cancers relapse after curative surgery. However, no method for distinguishing such tumors has yet been established...
  11. pmc Predictors of recurrence in breast cancer patients with a pathologic complete response after neoadjuvant chemotherapy
    M Tanioka
    Breast and Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    Br J Cancer 103:297-302. 2010
    ..This study was designed to identify factors predictive of recurrence in patients with pCR...
  12. ncbi request reprint A ferulic acid derivative, ethyl 3-(4'-geranyloxy-3-methoxyphenyl)-2-propenoate, as a new candidate chemopreventive agent for colon carcinogenesis in the rat
    B S Han
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan
    Jpn J Cancer Res 92:404-9. 2001
    ..The findings thus suggest that EGMP and FA, especially the former, might have potential as chemopreventive agents against colon tumor development...
  13. pmc Inhibitory effects of docosahexaenoic acid on colon carcinoma 26 metastasis to the lung
    M Iigo
    Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Br J Cancer 75:650-5. 1997
    ..The results indicate that uptake of DHA into tumour cells results in altered tumour cell membrane characteristics and a decreased ability to metastasize...
  14. ncbi request reprint Correlation of numerical and structural status of chromosome 16 with histological type and grade of non-invasive and invasive breast carcinomas
    H Tsuda
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Int J Cancer 84:381-7. 1999
    ..Int. J. Cancer (Pred. Oncol.) 84:381-387, 1999...
  15. ncbi request reprint The chemosensitivity of nodal metastases in recurrent epithelial ovarian cancer
    F Kataoka
    Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan
    Eur J Gynaecol Oncol 32:160-3. 2011
    ..In this study, we compared second-line chemotherapy effects of nodal metastases with other metastases sites...
  16. ncbi request reprint European registry comparisons provide evidence of shared risk factors for renal, colon and gallbladder cancer development
    M A Moore
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Eur J Cancer Prev 8:137-46. 1999
    ..The present findings also underline the necessity of distinguishing between tumour types within organs in epidemiological investigations of causal influences...
  17. ncbi request reprint Retrospective study comparing irinotecan and pegylated liposomal doxorubicin in treatment of recurrent platinum-refractory/resistant epithelial ovarian cancer
    H Nomura
    Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan
    Eur J Gynaecol Oncol 33:86-9. 2012
    ..In this study, we retrospectively compared the effect of irinotecan (CPT-11) and pegylated liposomal doxorubicin (PLD) in the treatment of platinum-resistant recurrent EOC...
  18. ncbi request reprint Diagnostic value of contrast-enhanced computed tomography for diagnosing the intraductal component of breast cancer
    S Akashi-Tanaka
    Department of Surgical Oncology, National Cancer Center Hospital, Tokyo, Japan
    Breast Cancer Res Treat 49:79-86. 1998
    ..We therefore tried to detect the intraductal components and small invasive foci of breast cancers by contrast-enhanced helical computed tomography (CE-CT)...
  19. pmc Modified primary tumour/vessel tumour/nodal tumour classification for patients with invasive ductal carcinoma of the breast
    T Hasebe
    Pathology Consultation Service, Clinical Trials and Practice Support Division, Center for Cancer Control and Information Services, National Cancer Center, 5 1 1, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Br J Cancer 105:698-708. 2011
    ....
  20. ncbi request reprint Inhibitory effects of bovine lactoferrin on intestinal polyposis in the Apc(Min) mouse
    Y Ushida
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Lett 134:141-5. 1998
    ..No toxic effects were observed in the intestinal epithelium. Although not as obvious as observed for the rat case, the data suggest that bLF may be a chemopreventor of intestinal polyposis...
  21. ncbi request reprint Pattern of chromosome 16q loss differs between an atypical proliferative lesion and an intraductal or invasive ductal carcinoma occurring subsequently in the same area of the breast
    H Tsuda
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Mod Pathol 14:382-8. 2001
    ..Although atypical proliferative lesions were frequently confirmed to be of clonal nature with LOH on 16q, these lesions and carcinomas were considered to be clones, probably originated from a field with these clones...
  22. ncbi request reprint Absence of endothelial cells, central necrosis, and fibrosis are associated with aggressive inflammatory breast cancer
    K Shirakawa
    Pharmacology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 61:445-51. 2001
    ..The molecular basis and these unique histological features may be associated with aggressive IBC on angiogenic and nonangiogenic pathways...
  23. ncbi request reprint Concordance in judgments among c-erbB-2 (HER2/neu) overexpression detected by two immunohistochemical tests and gene amplification detected by Southern blot hybridization in breast carcinoma
    H Tsuda
    Pathology Division, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Pathol Int 51:26-32. 2001
    ..Further examination would be necessary to decide the significance of breast cancers of HercepTestTM score 2...
  24. ncbi request reprint A case of malignant phyllodes tumor of the breast with osteosarcomatous features
    K Matsuo
    Department of Surgical Oncology, National Cancer Center Hospital, Tsukiji, 5-chome, Chuo-ku, Tokyo 104-0045, Japan
    Breast Cancer 8:79-83. 2001
    ..There was no evidence of generalized disease. She has been well 6 months after surgery without adjuvant therapy...
  25. pmc Squamoid features and expression of involucrin in primary breast carcinoma associated with high histological grade, tumour cell necrosis and recurrence sites
    H Tsuda
    Pathology Division, National Cancer Center Research Institute and Hospital, Chuo Ku, Tokyo, Japan
    Br J Cancer 75:1519-24. 1997
    ....
  26. ncbi request reprint Preferential occurrence of breast carcinomas with loss of chromosome 16q and der (16) t (1;16) / der (1;16) in middle-aged patients with hyperplasia of mammary glands
    H Tsuda
    Pathology Division, National Cancer Center Research Institute and Hospital, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Cancer Res 91:692-9. 2000
    ..High-level estrogens and / or sensitivity of mammary glandular cells to estrogens might induce breast cancers with structural changes of chromosome 16...
  27. ncbi request reprint Immunohistochemical study of c-erbB-2 oncoprotein overexpression in human major salivary gland carcinoma: an indicator of aggressiveness
    S Sugano
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Laryngoscope 102:923-7. 1992
    ..05). We conclude that immunohistochemical positivity for c-erbB-2 is an indicator of aggressiveness in both adenocarcinoma and adenocarcinoma in pleomorphic adenoma of the major salivary glands...
  28. ncbi request reprint Two special types of breast cancer presenting as progressive disease after neoadjuvant chemotherapy with docetaxel plus doxorubicin
    T Takahashi
    Breasr Surgery Division, National Cancer Hospital, Tokyo, Japan
    Breast Cancer 8:234-7. 2001
    ..There were 4 cases of IBC and one case of SCC of the breast who received neoadjuvant chemotherapy in this series. Our observations suggest that this regimen might not be effective for these types of breast cancer...
  29. ncbi request reprint Organotropic chemopreventive effects of n-3 unsaturated fatty acids in a rat multi-organ carcinogenesis model
    H Toriyama-Baba
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tokyo
    Jpn J Cancer Res 92:1175-83. 2001
    ..The data thus provide evidence that an organotropism exists with regard to the influence of UFAs on carcinogenesis, which correlates with reduction of tissue AA levels in the target organs...
  30. ncbi request reprint Marriage of a medium-term liver model to surrogate markers--a practical approach for risk and benefit assessment
    M A Moore
    Division of Chemotherapy, National Cancer Research Center, Tokyo, Japan
    Toxicol Pathol 27:237-42. 1999
    ....
  31. ncbi request reprint Heterozygous p53-deficient mice are not susceptible to 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) carcinogenicity
    C B Park
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Lett 139:177-82. 1999
    ..The results indicate that p53+/- mice have no practical advantages for use in short-term carcinogenicity tests of HCAs...
  32. ncbi request reprint der(16)t(1;16)/der(1;16) in breast cancer detected by fluorescence in situ hybridization is an indicator of better patient prognosis
    H Tsuda
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Genes Chromosomes Cancer 24:72-7. 1999
    ..05). der(16)t(1;16)/der(1;16) detected by FISH is considered helpful in identifying patients with a better prognosis and for stratification of patients in randomized clinical trials of adjuvant chemo-endocrine therapies...
  33. ncbi request reprint Histogenetic stereological reconstruction of rat basophilic, clear, and oncocytic neoplastic renal cell lesions using carbonic anhydrase type II-PAS double-stained sections
    H Tsuda
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Toxicol Pathol 26:769-76. 1998
    ..The results indicate that the origins of renal cell neoplasia are proximal tubules for the basophilic cell lesions, either proximal or distal tubules for their clear cell counterparts, and collecting ducts for oncocytic lesions...
  34. ncbi request reprint Enhanced quinone reductase (QR) activity correlates with promotion potential of diethyl maleate (DEM) in rat forestomach and glandular stomach carcinogenesis initiated with N-methyl-N'-nitrosoguanidine (MNNG)
    D J Kim
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Lett 137:193-200. 1999
    ..Induction of QR, a Phase II enzyme, activity in the rat stomach by DEM may be associated with promotion of stomach carcinogenesis rather than inhibition...
  35. ncbi request reprint The efficacy and limitations of repeated slide conferences for improving interobserver agreement when judging nuclear atypia of breast cancer. The Japan National Surgical Adjuvant Study of Breast Cancer (NSAS-BC) Pathology Section
    H Tsuda
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Jpn J Clin Oncol 29:68-73. 1999
    ....
  36. ncbi request reprint Cholangiocarcinomas in Japanese and Thai patients: difference in etiology and incidence of point mutation of the c-Ki-ras proto-oncogene
    H Tsuda
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Mol Carcinog 6:266-9. 1992
    ..On the other hand, point-mutational activation of the c-Ki-ras proto-oncogene may be involved in cholangiocarcinogenesis in liver without preexisting liver-fluke or viral infection...
  37. ncbi request reprint Contrast-enhanced computed tomography detection of occult breast cancers presenting as axillary masses
    S Akashi-Tanaka
    Department of Surgical Oncology, National Cancer Center Hospital, Tokyo, Japan
    Breast Cancer Res Treat 55:97-101. 1999
    ..We performed contrast-enhanced computed tomography (CE-CT) in order to locate the primary tumors in five cases of OBC and succeeded in locating all of them...
  38. pmc Frequent GNAS mutations in low-grade appendiceal mucinous neoplasms
    G Nishikawa
    Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo 104 0045, Japan
    Br J Cancer 108:951-8. 2013
    ..The molecular basis for the development of appendiceal mucinous tumours, which can be a cause of pseudomyxoma peritonei, remains largely unknown...
  39. doi request reprint SIX1 promotes epithelial-mesenchymal transition in colorectal cancer through ZEB1 activation
    H Ono
    Department of Molecular Cytogenetics, Tokyo Medical and Dental University, Tokyo, Japan
    Oncogene 31:4923-34. 2012
    ..Taken together, SIX1 overexpression is suggested to occur in carcinogenesis, and contribute to repression of CDH1 expression and promotion of EMT partly through repression of miR-200-family expression and activation of ZEB1 in CRC...
  40. ncbi request reprint Frequent methylation-associated silencing of a candidate tumor-suppressor, CRABP1, in esophageal squamous-cell carcinoma
    K Tanaka
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    Oncogene 26:6456-68. 2007
    ..Its expression status in biopsies or resected tumors might serve as an index for identifying ESCC patients for whom combined therapeutic modalities would be recommended...
  41. ncbi request reprint Combined measurement of the c-erbB-2 protein in breast carcinoma tissues and sera is useful as a sensitive tumor marker for monitoring tumor relapse
    K Sugano
    Division of Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan
    Int J Cancer 89:329-36. 2000
    ....
  42. doi request reprint Expression of cIAP-1 correlates with nodal metastasis in squamous cell carcinoma of the tongue
    S Qi
    Oral and Maxillofacial Surgery, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Int J Oral Maxillofac Surg 37:1047-53. 2008
    ..These results suggest that both patterns of cIAP-1 are useful markers for predicting cervical lymph node metastasis in tongue SCC...
  43. ncbi request reprint Detection of alterations in chromosomes 16 and 1 by fluorescence in situ hybridization in breast tumors cytologically or histologically equivocal for malignancy
    H Tsuda
    Pathology Division, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Pathobiology 66:268-73. 1998
    ..As a supportive diagnostic procedure, FISH analysis may give information about the nature of lesions, when the lesions are clinically or pathologically equivocal for cancer...
  44. ncbi request reprint Multiple developmental pathways of highly aggressive breast cancers disclosed by comparison of histological grades and c-erbB-2 expression patterns in both the non-invasive and invasive portions
    H Tsuda
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Pathol Int 48:518-25. 1998
    ..The histological grade and c-erbB-2 overexpression appeared to be largely established during the early microscopic stages of a DCIS or invasive carcinoma...
  45. ncbi request reprint Cross-country comparisons suggest shared risk factors for carcinomas, including male lung adenocarcinoma and colon cancer development
    M A Moore
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Lung Cancer 24:149-55. 1999
    ..The results suggest that blood borne factors, like hormones, may be important as determinants for the increasingly prevalent lung AC...
  46. ncbi request reprint A quantitative model using mean and standard deviation for evaluation of interobserver agreement in nuclear atypia scoring of breast carcinomas in a protocol study
    H Tsuda
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Pathol Int 50:119-25. 2000
    ..The present method was considered to be complementary to conventional methods for evaluating interobserver agreement of cancer histology in protocol studies...
  47. ncbi request reprint Differences in estrogen receptor status, HER2, and p53 comparing metachronous bilateral breast carcinoma
    K Matsuo
    Department of Surgical Oncology, National Cancer Center Hospital, Tokyo, Japan
    J Surg Oncol 77:31-4. 2001
    ....
  48. pmc Molecular detection of lymph node metastasis in breast cancer patients treated with preoperative systemic chemotherapy: a prospective multicentre trial using the one-step nucleic acid amplification assay
    T Osako
    1 Division of Pathology, The Cancer Institute of Japanese Foundation for Cancer Research, Tokyo, Japan 2 Department of Pathology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan
    Br J Cancer 109:1693-8. 2013
    ..In this prospective multicentre trial, we assessed the performance of the OSNA assay in detecting nodal metastasis after chemotherapy...
  49. doi request reprint Comparison of chemotherapeutic treatment outcomes of advanced extrapulmonary neuroendocrine carcinomas and advanced small-cell lung carcinoma
    T Terashima
    Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    Neuroendocrinology 96:324-32. 2012
    ..The aim of this study was to clarify the efficacy of standard SCLC regimens when used to treat EP-NECs and to compare the outcome with that for SCLC...
  50. doi request reprint Diagnostic and prognostic significance of the alternatively spliced ACTN4 variant in high-grade neuroendocrine pulmonary tumours
    A Miyanaga
    Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Tokyo, Japan
    Ann Oncol 24:84-90. 2013
    ..High-grade neuroendocrine tumours (HGNTs) of the lung manifest a wide spectrum of clinical behaviour, but no method for predicting their outcome has been established...
  51. ncbi request reprint Unargued issues on the pathological assessment of response in primary systemic therapy for breast cancer
    K Kuroi
    c o Komagome Hospital, Honkomagome, Bunkyo ku, Tokyo, Japan
    Biomed Pharmacother 59:S387-92. 2005
    ..In this review, we highlight the issues of pathologic evaluation after PST...
  52. pmc Radical hysterectomy for FIGO stage I-IIB adenocarcinoma of the uterine cervix
    T Kasamatsu
    Division of Gynecology, National Cancer Center Hospital, Tokyo, Japan
    Br J Cancer 100:1400-5. 2009
    ..FIGO stage I-IIB patients with AC or SCC, who underwent radical hysterectomy, have similar prognosis and spread pattern, but different ovarian metastasis rates...
  53. pmc Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion
    K Honda
    Pathology Division, National Cancer Center Research Institute, Tokyo 104, Japan
    J Cell Biol 140:1383-93. 1998
    ..These findings suggest that cytoplasmic actinin-4 regulates the actin cytoskeleton and increases cellular motility and that its inactivation by transfer to the nucleus abolishes the metastatic potential of human cancers...
  54. ncbi request reprint Evaluation of the interobserver agreement in the number of mitotic figures of breast carcinoma as simulation of quality monitoring in the Japan National Surgical Adjuvant Study of Breast Cancer (NSAS-BC) protocol
    H Tsuda
    Pathology Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Cancer Res 91:451-7. 2000
    ..The selection of the counting area was confirmed to be important for the acquisition of high-level agreement level in mitotic counts...
  55. ncbi request reprint Global effects of anchorage on gene expression during mammary carcinoma cell growth reveal role of tumor necrosis factor-related apoptosis-inducing ligand in anoikis
    G S Goldberg
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 61:1334-7. 2001
    ..These findings suggest that TRAIL may be used as a means to target circulating epithelial tumor cells before their attachment and colonization at new sites...
  56. doi request reprint Human epidermal growth factor receptor 2 protein overexpression and gene amplification in extramammary Paget disease
    R Tanaka
    Department of Dermatologic Oncology, National Cancer Center Hospital, Tokyo, Japan
    Br J Dermatol 168:1259-66. 2013
    ..However, there are only a few cases in which both overexpression and gene amplification of HER2 have been examined...
  57. ncbi request reprint Mutations of the p53 tumor suppressor gene and the ras gene family in intrahepatic cholangiocellular carcinomas in Japan and Thailand
    T Kiba
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Mol Carcinog 8:312-8. 1993
    ..Therefore, in contrast to the ras oncogenes, mutation of the p53 gene was frequently involved in the development of CCCs in both Japanese and Thai patients, irrespective of any difference in etiology...
  58. ncbi request reprint Primary epithelioid sarcoma of the vulva
    T Kasamatsu
    Division of Gynecology, National Cancer Center Hospital, Tokyo, Japan
    Int J Gynecol Cancer 11:316-20. 2001
    ..Radical vulvectomy or extensive local excision with inguinal lymphadenectomy at the time of diagnosis is recommended as the treatment of choice...
  59. ncbi request reprint Detection of numerical alterations of chromosome 1 in cytopathological specimens of breast tumors by chromogen in situ hybridization
    T Takarabe
    Pathology Division, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Pathol Int 51:786-91. 2001
    ..In addition, the CISH method was superior in the detection of numerical alterations in carcinoma cells by referring to the morphology of cells and in the detection of significant clones which might be missed under dark-field microscopy...
  60. ncbi request reprint Genomic loss and epigenetic silencing of very-low-density lipoprotein receptor involved in gastric carcinogenesis
    H Takada
    Department of Molecular Cytogenetics, Medical Research Institute and Graduate School of Biomedical Science, Tokyo, Japan
    Oncogene 25:6554-62. 2006
    ..These results suggest that not only the expression of VLDLR but also genetic or epigenetic silencing of this gene may contribute to tumor formation and be involved in gastric carcinogenesis...
  61. ncbi request reprint Decreased CD161+CD8+ T cells in the peripheral blood of patients suffering from rheumatic diseases
    A Mitsuo
    Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, 2 1 1 Hongo, Tokyo, Japan
    Rheumatology (Oxford) 45:1477-84. 2006
    ....
  62. ncbi request reprint Effects of third-line chemotherapy for women with recurrent ovarian cancer who received platinum/taxane regimens as first-line chemotherapy
    T Chiyoda
    Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan
    Eur J Gynaecol Oncol 31:364-8. 2010
    ..At present, it remains unclear whether the third-line chemotherapy has clinical benefit. In this study, we retrospectively evaluated the effect of third-line chemotherapy...
  63. ncbi request reprint Current topics on cytapheresis technologies
    K Yamaji
    Department of Internal Medicine and Rheumatology, Juntendo University, Tokyo, Japan
    Ther Apher 5:287-92. 2001
    ..This review introduces current cytapheresis technologies and attempts to elucidate the effective mechanism of cytapheresis for immune disorders, focused on LCAP and/or GCAP for RA or IBD...
  64. pmc c-MET expression in myofibroblasts: role in autocrine activation and prognostic significance in lung adenocarcinoma
    M Tokunou
    Pathology Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
    Am J Pathol 158:1451-63. 2001
    ..0019 by log-rank test). These data suggest that the HGF/c-MET system constitutes an autocrine activation loop in cancer-stromal myofibroblasts. This autocrine system may play a role in invasion and metastasis of lung adenocarcinoma...
  65. ncbi request reprint Molecular cloning of rat phosphoprotein phosphatase 2A beta cDNA and increased expressions of phosphatase 2A alpha and 2A beta in rat liver tumors
    Y Kitagawa
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Biochem Biophys Res Commun 157:821-7. 1988
    ..0 kb mRNA transcript and a minor 1.4 kb mRNA transcript. These transcripts were both greatly increased in rat liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) regardless of the carcinoma or hyperplastic nodule...
  66. pmc Tumour necrosis is a postoperative prognostic marker for pancreatic cancer patients with a high interobserver reproducibility in histological evaluation
    N Hiraoka
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Br J Cancer 103:1057-65. 2010
    ..The aim of this study was to investigate whether histological necrosis is a useful predictor of outcome in patients with pancreatic ductal carcinoma (PDC)...
  67. ncbi request reprint Rat neuronal leucine-rich repeat protein-3: cloning and regulation of the gene expression
    K Fukamachi
    Experimental Pathology and Chemotherapy Division, Biophysics Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Biochem Biophys Res Commun 287:257-63. 2001
    ..LY294002, a PI3 kinase inhibitor, showed a lesser effect on expression of the gene. These results indicate that rNLRR-3 gene expression is regulated mainly through the Ras-MAPK signaling pathway in fibroblasts...
  68. ncbi request reprint A 2-Mb sequence-ready contig map and a novel immunoglobulin superfamily gene IGSF4 in the LOH region of chromosome 11q23.2
    H Gomyo
    Radiobiology Division, Oncogene Division, Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Genomics 62:139-46. 1999
    ..The IGSF4 gene, a novel gene that is shown to be located in the common loss of heterozygosity region, possesses a number of interesting features and may be good candidate for a tumor suppressor gene...
  69. ncbi request reprint Nested polymerase chain reaction for assessing the clinical course of tuberculous meningitis
    T Takahashi
    Division of Neurology, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan
    Neurology 64:1789-93. 2005
    ..During anti-tuberculosis treatments, N-PCR results converted from positive to negative, correlating with the improvement of the patient's clinical condition...
  70. ncbi request reprint Point mutation of the E-cadherin gene in invasive lobular carcinoma of the breast
    Y Kanai
    Pathology Division, National Cancer Center Research Institute, Tokyo
    Jpn J Cancer Res 85:1035-9. 1994
    ..This mutation may abolish the E-cadherin-mediated cell-cell adhesion and be at least partly responsible for the weak intercellular adhesiveness and scattered histological pattern of the tumor...
  71. doi request reprint Butyrate, a bacterial metabolite, induces apoptosis and autophagic cell death in gingival epithelial cells
    H Tsuda
    Department of Biochemistry, Nihon University School of Dentistry, Tokyo, Japan
    J Periodontal Res 45:626-34. 2010
    ..Although butyrate reportedly has a variety of effects in many mammalian cells, its effect on gingival epithelial cells is not well known. In this study, we investigated the effect of butyrate on gingival epithelial Ca9-22 cell death...
  72. ncbi request reprint Update results of FEC followed by docetaxel neoadjuvant trials for primary breast cancer
    S Ohnoa
    Japan Breast Cancer Research Group, c o Komagome Hospital, Bunkyo ku, Tokyo, Japan
    Biomed Pharmacother 59:S323-4. 2005
    ..The pathologic response rate was 17%. In this ongoing trial, FEC followed by DOC was active and well tolerated...
  73. ncbi request reprint Temperament and job stress in Japanese company employees
    Y Sakai
    Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan
    J Affect Disord 85:101-12. 2005
    ..This study aims to demonstrate the relevance of temperament to job stress...
  74. ncbi request reprint Down-regulation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced CYP1A2 expression is associated with bovine lactoferrin inhibition of MeIQx-induced liver and colon carcinogenesis in rats
    Ken ichi Fujita
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045
    Jpn J Cancer Res 93:616-25. 2002
    ..One possible mechanism is a normalizing down-regulation of CYP1A2 expression by bLF, with consequent reduction of carcinogen activation and adduct formation...
  75. ncbi request reprint Possible application of human c-Ha-ras proto-oncogene transgenic rats in a medium-term bioassay model for carcinogens
    Takamasa Ohnishi
    Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Toxicol Pathol 35:436-43. 2007
    ..Thus various carcinogens, not necessarily limited to those normally targeting the breast, were found to induce mammary carcinomas in Hras128 rats, especially in females, pointing to potential use for medium-term screening...
  76. ncbi request reprint Can risk assessment and chemoprevention research rely on surrogates for tumour yield?
    Malcolm A Moore
    Asian Pac J Cancer Prev 4:167-8. 2003
  77. ncbi request reprint Possible enhancing activity of diacylglycerol on 4-nitroquinoline 1-oxide induced carcinogenesis of the tongue in human c-Ha-ras proto-oncogene transgenic rats
    Hiroyuki Tsuda
    Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Food Chem Toxicol 45:1013-9. 2007
    ..Tongue SCC induction of wild males and all females was not significant. The present results suggest that DAG oil may have enhancing and/or promotion potential for tongue carcinogenesis in male Tg featuring elevated ras expression...
  78. ncbi request reprint Molecular analysis of rat mammary carcinogenesis: an approach from carcinogenesis research to cancer prevention
    Yoichiro Matsuoka
    Second Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi, Osaka, Japan
    Med Mol Morphol 40:185-90. 2007
    ..In this review, we summarize molecular aspects of mammary carcinogenesis in transgenic rats and the potential application of this model for studies of breast cancer prevention...
  79. ncbi request reprint Ductal origin of pancreatic adenocarcinomas induced by conditional activation of a human Ha-ras oncogene in rat pancreas
    Shinobu Ueda
    Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Carcinogenesis 27:2497-510. 2006
    ..This model exhibits important similarities to the human disease and promises to advance our understanding of the behavior of pancreas adenocarcinomas and expedite screening and therapy...
  80. ncbi request reprint Rapid emergence of mammary preneoplastic and malignant lesions in human c-Ha-ras proto-oncogene transgenic rats: possible application for screening of chemopreventive agents
    Yoichiro Matsuoka
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Toxicol Pathol 31:632-7. 2003
    ..These results suggest that this model has practical utility for short-term screening of chemopreventive agents for mammary carcinogenesis...
  81. ncbi request reprint Lack of effect of human c-Ha-ras proto-oncogene overexpression on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats
    Naomi Hokaiwado
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601
    Cancer Sci 94:1042-5. 2003
    ....
  82. ncbi request reprint Gpx2 is an overexpressed gene in rat breast cancers induced by three different chemical carcinogens
    Aya Naiki-Ito
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya, Japan
    Cancer Res 67:11353-8. 2007
    ..Thus, these data suggested that GPX2 may be involved in mammary carcinogenesis and cell proliferation in both rats and humans, indicating that GPX2 may be a novel target for the prevention and therapy of breast cancer...
  83. doi request reprint Induction of a novel histone deacetylase 1/c-Myc/Mnt/Max complex formation is implicated in parity-induced refractoriness to mammary carcinogenesis
    Yoichiro Matsuoka
    Second Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi, Osaka 570 8506, Japan
    Cancer Sci 99:309-15. 2008
    ....
  84. ncbi request reprint Inhibitory effects of 17beta-estradiol and 4-n-octylphenol on 7,12-dimethylbenz[a]anthracene-induced mammary tumor development in human c-Ha-ras proto-oncogene transgenic rats
    Beom Seok Han
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 23:1209-15. 2002
    ..In addition, the results suggest that Tg rats can be used in medium-term bioassay models to test for the modifying effects of estrogenic environmental compounds on mammary tumor development...
  85. ncbi request reprint Transgenic rats carrying human c-Ha-ras proto-oncogene are highly susceptible to N-nitrosomethylbenzylamine induction of esophageal tumorigenesis
    Makoto Asamoto
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Cancer Res 93:744-51. 2002
    ....
  86. ncbi request reprint Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats
    Hiroyuki Kohno
    First Department of Pathology, Kanazawa Medical University, Ishikawa, Japan
    Int J Cancer 101:461-8. 2002
    ....
  87. ncbi request reprint Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine
    Shoji Fukushima
    Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Jpn J Cancer Res 93:1076-82. 2002
    ..These results imply that there is a no-observed effect level for hepatocarcinogenesis by these genotoxic carcinogens...
  88. ncbi request reprint A novel geranylated derivative, ethyl 3-(4'-geranyloxy-3'-methoxyphenyl)-2-propenoate, synthesized from ferulic acid suppresses carcinogenesis and inducible nitric oxide synthase in rat tongue
    Takuji Tanaka
    Department of Pathology, Kanazawa Medical University, Ishikawa, Japan
    Oncology 64:166-75. 2003
    ....
  89. ncbi request reprint Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline
    Shoji Fukushima
    Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Cancer Lett 191:35-40. 2003
    ..001-1 ppm. The results imply a no-observed effect level for hepatocarcinogenicity with this genotoxic agent...
  90. ncbi request reprint Appropriate models and an understanding of carcinogenic mechanisms--requirements for hazard risk assessment
    Shoji Fukushima
    Department of Pathology, Osaka City University Medical School, Asahi machi, Osaka 545 8585, Japan
    Asian Pac J Cancer Prev 4:75-8. 2003
    ..The onus is on all members of the scientific community to impartially view all the epidemiological and experimental data which are available in decision-making...
  91. ncbi request reprint Possible enhancing effects of atrazine and nonylphenol on 7,12-dimethylbenz[a]anthracene-induced mammary tumor development in human c-Ha-ras proto-oncogene transgenic rats
    Katsumi Fukamachi
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 95:404-10. 2004
    ..The doses applied, moreover, were all extremely high compared to the possible environmental human exposure levels...
  92. ncbi request reprint Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis
    Masaaki Iigo
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cytokine 25:36-44. 2004
    ....
  93. ncbi request reprint Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats
    Keiichirou Morimura
    Department of Pathology, Osaka City University Medical School, Osaka, Japan
    Toxicol Pathol 33:764-7. 2005
    ..In conclusion, Na-AsA did not show tumorigenicity in highly bladder-cancer-susceptible transgenic Hras128 rats. These results suggest that Na-AsA is a pure promoter but not a complete carcinogen in rats...
  94. ncbi request reprint Lactoferrin enhances Fas expression and apoptosis in the colon mucosa of azoxymethane-treated rats
    Ken ichi Fujita
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 25:1961-6. 2004
    ..These results suggest that apoptosis caused by elevated expression of Fas is involved in chemoprevention by lactoferrin of colon carcinogenesis...
  95. ncbi request reprint Establishment of human osteosarcoma cell lines with high metastatic potential to lungs and their utilities for therapeutic studies on metastatic osteosarcoma
    Kenji Kimura
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Clin Exp Metastasis 19:477-85. 2002
    ..These results indicate that both ADR and IL-12 are effective agents against pulmonary metastatic osteosarcoma, and that these sublines are useful for studies on the biological behavior and treatment of pulmonary metastatic osteosarcoma...
  96. ncbi request reprint Preferential mammary carcinogenic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human c-Ha-ras proto-oncogene transgenic rats
    Akihiro Naito
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 95:399-403. 2004
    ....
  97. ncbi request reprint Lactoferrin modifies apoptosis-related gene expression in the colon of the azoxymethane-treated rat
    Ken ichi Fujita
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Lett 213:21-9. 2004
    ..These results indicate that Fas and pro-apoptotic Bcl-2 members participate in the lactoferrin action and may contribute to suppressive effects on tumor development in the rat colon...
  98. ncbi request reprint Chemoprevention of colorectal cancer by grape seed proanthocyanidin is accompanied by a decrease in proliferation and increase in apoptosis
    Hiroshi Nomoto
    Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Nutr Cancer 49:81-8. 2004
    ..PA at fairly low doses in the long term might serve as an effective means for preventing colon carcinogenesis...
  99. ncbi request reprint Bovine lactoferrin inhibits tumor-induced angiogenesis
    Mariko Shimamura
    Medical R and D Center, The Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
    Int J Cancer 111:111-6. 2004
    ..Antitumor activity of bLF may thus be partly mediated by angiogenesis inhibition...
  100. ncbi request reprint Lack of potential of low dose N-nitrosodimethylamine to induce preneoplastic lesions, glutathione S-transferase placental form-positive foci, in rat liver
    Shoji Fukushima
    Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Cancer Lett 222:11-5. 2005
    ....
  101. ncbi request reprint Lack of modifying effects of 4-ter t-octylphenol and benzyl butyl phthalate on 3,2-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in rats
    Hiroyuki Kohno
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Cancer Sci 95:300-5. 2004
    ..These results might suggest that dietary feeding of the estrogenic compounds tOP and BBP did not modulate DMAB-induced prostatic carcinogenesis in rats...