Makoto Tominaga

Summary

Affiliation: National Institute for Physiological Sciences
Country: Japan

Publications

  1. ncbi request reprint [Molecular mechanisms of thermosensation]
    Makoto Tominaga
    Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki, Aichi 444 8787, Japan
    Nihon Yakurigaku Zasshi 124:219-27. 2004
  2. pmc Activation of polycystic kidney disease-2-like 1 (PKD2L1)-PKD1L3 complex by acid in mouse taste cells
    Hitoshi Kawaguchi
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    J Biol Chem 285:17277-81. 2010
  3. ncbi request reprint Thermosensation and pain
    Makoto Tominaga
    Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    J Neurobiol 61:3-12. 2004
  4. ncbi request reprint Regulation mechanisms of vanilloid receptors
    Makoto Tominaga
    Department of Cellular and Molecular Physiology, Mie University School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    Novartis Found Symp 261:4-12; discussion 12-8, 47-54. 2004
  5. pmc Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins
    Tomoko Moriyama
    Dept of Cellular and Molecular Physiology, Mie University School of Medicine, Mie 514 8507, Japan
    Mol Pain 1:3. 2005
  6. ncbi request reprint Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1
    Yasunori Takayama
    1Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    FASEB J 28:2238-48. 2014
  7. pmc Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice
    Kunitoshi Uchida
    National Institutes of Natural Sciences, Okazaki, Japan
    Diabetes 60:119-26. 2011
  8. pmc TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP
    Sravan Mandadi
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, Okazaki, Japan
    Pflugers Arch 458:1093-102. 2009
  9. pmc Involvement of TRPA1 activation in acute pain induced by cadmium in mice
    Saeko Miura
    Department of Veterinary Pharmacology, Faculty of Agriculture, Tottori University, Tottori 680 8553, Japan
    Mol Pain 9:7. 2013
  10. pmc TRPM8 mechanism of autonomic nerve response to cold in respiratory airway
    Hong Xing
    Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, McKnight Brain Institute and College of Dentistry, University of Florida, Gainesville, Florida 32610, USA
    Mol Pain 4:22. 2008

Detail Information

Publications79

  1. ncbi request reprint [Molecular mechanisms of thermosensation]
    Makoto Tominaga
    Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki, Aichi 444 8787, Japan
    Nihon Yakurigaku Zasshi 124:219-27. 2004
    ..With these clones in hand, we can begin to understand thermosensation from a molecular standpoint...
  2. pmc Activation of polycystic kidney disease-2-like 1 (PKD2L1)-PKD1L3 complex by acid in mouse taste cells
    Hitoshi Kawaguchi
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    J Biol Chem 285:17277-81. 2010
    ..Thus, PKD2L1-PKD1L3-mediated acid-evoked off responses occurred both in HEK293 cells and in native taste cells, suggesting the involvement of the PKD2L1-PKD1L3 complex in acid sensing in vivo...
  3. ncbi request reprint Thermosensation and pain
    Makoto Tominaga
    Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    J Neurobiol 61:3-12. 2004
    ..TRPV2, TRPM8, and TRPA1 are also very likely to be involved in thermal nociception, because their activation thresholds are within the noxious range of temperatures...
  4. ncbi request reprint Regulation mechanisms of vanilloid receptors
    Makoto Tominaga
    Department of Cellular and Molecular Physiology, Mie University School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    Novartis Found Symp 261:4-12; discussion 12-8, 47-54. 2004
    ..The Ca2+ -binding protein calmodulin binds to the C-terminus of TRPV1. We found that disruption of the calmodulin binding segment prevented TRPV1 desensitization even in the presence of extracellular Ca2+...
  5. pmc Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins
    Tomoko Moriyama
    Dept of Cellular and Molecular Physiology, Mie University School of Medicine, Mie 514 8507, Japan
    Mol Pain 1:3. 2005
    ..Thus, the potentiation or sensitization of TRPV1 activity through EP1 or IP activation might be one important mechanism underlying the peripheral nociceptive actions of PGE2 or PGI2...
  6. ncbi request reprint Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1
    Yasunori Takayama
    1Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    FASEB J 28:2238-48. 2014
    ..Takayama, Y., Shibasaki, K., Suzuki, Y., Yamanaka, A., Tominaga, M. Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1. ..
  7. pmc Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice
    Kunitoshi Uchida
    National Institutes of Natural Sciences, Okazaki, Japan
    Diabetes 60:119-26. 2011
    ..To clarify the involvement of TRPM2 in insulin secretion, we analyzed TRPM2 knockout (TRPM2-KO) mice...
  8. pmc TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP
    Sravan Mandadi
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, Okazaki, Japan
    Pflugers Arch 458:1093-102. 2009
    ..This study provides evidence that ATP is a messenger molecule for mainly TRPV3-mediated thermotransduction in skin...
  9. pmc Involvement of TRPA1 activation in acute pain induced by cadmium in mice
    Saeko Miura
    Department of Veterinary Pharmacology, Faculty of Agriculture, Tottori University, Tottori 680 8553, Japan
    Mol Pain 9:7. 2013
    ..In addition, we examined whether Cd caused acute pain in vivo...
  10. pmc TRPM8 mechanism of autonomic nerve response to cold in respiratory airway
    Hong Xing
    Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, McKnight Brain Institute and College of Dentistry, University of Florida, Gainesville, Florida 32610, USA
    Mol Pain 4:22. 2008
    ..This putative autonomic response may be associated with cold-induced exacerbation of asthma and other pulmonary disorders, making TRPM8 receptors a possible target for prevention of cold-associated respiratory disorders...
  11. pmc Evolutionary conservation and changes in insect TRP channels
    Hironori Matsuura
    Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464 8601, Japan
    BMC Evol Biol 9:228. 2009
    ....
  12. ncbi request reprint Structure and function of TRPV1
    Makoto Tominaga
    Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    Pflugers Arch 451:143-50. 2005
    ..Given the fact that TRPV1 is a key molecule in peripheral nociception, these regions and amino acids could prove useful for the development of novel anti-nociceptive or anti-inflammatory agents...
  13. ncbi request reprint [Activation and regulation of nociceptive transient receptor potential (TRP) channels, TRPV1 and TRPA1]
    Makoto Tominaga
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience National Institute for Physiological Sciences, National Institutes of Natural Sciences, Japan
    Yakugaku Zasshi 130:289-94. 2010
    ..These results suggest that alkaline pH causes pain sensation through activation of TRPA1...
  14. ncbi request reprint [TRP channels and nociception]
    Makoto Tominaga
    Nihon Yakurigaku Zasshi 127:128-32. 2006
  15. ncbi request reprint [TRPV1 in gastrointestinal organs]
    Makoto Tominaga
    Nihon Yakurigaku Zasshi 128:78-81. 2006
  16. ncbi request reprint Molecular mechanisms of trigeminal nociception and sensation of pungency
    Makoto Tominaga
    Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Japan
    Chem Senses 30:i191-2. 2005
  17. pmc Conditional ablation of orexin/hypocretin neurons: a new mouse model for the study of narcolepsy and orexin system function
    Sawako Tabuchi
    Research Institute of Environmental Medicine, Nagoya University, Nagoya, 464 8601, Japan, Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki 444 8585, Japan, Japan Society for the Promotion of Science, Tokyo 102 8472, Japan, Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California 94025, Division of Cell Signaling, National Institute for Physiological Sciences, National Institute of Natural Sciences, Okazaki 444 8787, Japan, Center for Multidisciplinary Brain Research, National Institute for Physiological Sciences, National Institute of Natural Sciences, Okazaki 444 8585, Japan, Division of Endocrinology and Metabolism, National Institute for Physiological Sciences, National Institute of Natural Sciences, Okazaki 444 8585, Japan, and Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa 920 8640, Japan
    J Neurosci 34:6495-509. 2014
    ....
  18. pmc Influence of inhibitory serotonergic inputs to orexin/hypocretin neurons on the diurnal rhythm of sleep and wakefulness
    Sawako Tabuchi
    National Institute for Physiological Sciences, National Institute of Natural Sciences, Okazaki, Japan
    Sleep 36:1391-404. 2013
    ..However, the physiological significance of this negative feedback circuit for sleep/wakefulness regulation is little understood...
  19. doi request reprint Identification of a splice variant of mouse TRPA1 that regulates TRPA1 activity
    Yiming Zhou
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan
    Nat Commun 4:2399. 2013
    ..These results suggest that TRPA1 may be regulated through alternative splicing under these pathological conditions. ..
  20. ncbi request reprint Effects of body temperature on neural activity in the hippocampus: regulation of resting membrane potentials by transient receptor potential vanilloid 4
    Koji Shibasaki
    Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    J Neurosci 27:1566-75. 2007
    ..We conclude that TRPV4 is activated by physiological temperature in hippocampal neurons and thereby controls their excitability...
  21. doi request reprint Involvement of TRPV2 activation in intestinal movement through nitric oxide production in mice
    Hiroshi Mihara
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    J Neurosci 30:16536-44. 2010
    ..In conclusion, TRPV2 may contribute to intestinal motility through NO production, and TRPV2 is a promising target for controlling intestinal movement...
  22. doi request reprint Metabolic adaptation of mice in a cool environment
    Kunitoshi Uchida
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience National Institute for Physiological Sciences, National Institutes of Natural Sciences, Higashiyama 5 1 Myodaiji, Okazaki, Aichi 444 8787, Japan
    Pflugers Arch 459:765-74. 2010
    ..These adaptations can be interpreted as preparation for a further reduction in ambient temperature...
  23. pmc Activation of transient receptor potential A1 by a non-pungent capsaicin-like compound, capsiate
    Kenji Shintaku
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Aichi, Japan
    Br J Pharmacol 165:1476-86. 2012
    ..We previously reported that capsiate could activate transient receptor potential vanilloid 1 (TRPV1), a capsaicin receptor. The purpose of the present study is to investigate whether capsinoids activate other TRP channels...
  24. doi request reprint Ambient temperature affects the temperature threshold for TRPM8 activation through interaction of phosphatidylinositol 4,5-bisphosphate
    Fumitaka Fujita
    Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    J Neurosci 33:6154-9. 2013
    ..These findings suggest that ambient temperature does affect the temperature threshold for TRPM8 activation through interaction of PIP2...
  25. doi request reprint Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner
    Tomoko Komatsu
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience National Institute for Physiological Sciences, National Institutes of Natural Sciences, Higashiyama 5 1, Myodaiji, Okazaki, Aichi, Japan
    Pflugers Arch 463:549-59. 2012
    ..We conclude that primary and secondary alcohols activate hTRPA1 in a carbon chain length-dependent manner. TRPA1 could be a sensor of alcohols inducing skin, eye and nasal irritation in human...
  26. pmc Transient receptor potential vanilloid 4 (TRPV4)-dependent calcium influx and ATP release in mouse oesophageal keratinocytes
    Hiroshi Mihara
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki, Aichi 444 8787, Japan
    J Physiol 589:3471-82. 2011
    ..In conclusion, in response to heat, chemical and possibly mechanical stimuli, TRPV4 contributes to ATP release in the oesophagus. Thus, TRPV4 could be involved in oesophageal mechano- and heat hypersensitivity...
  27. pmc Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice
    Tomomi Tsunematsu
    Division of Cell Signaling, National Institute for Physiological Sciences, Okazaki 444 8787, Japan
    J Neurosci 31:10529-39. 2011
    ..The results presented here advance our understanding of the role of orexin neurons in the regulation of sleep/wakefulness and may be relevant to the mechanisms that underlie symptom progression in narcolepsy...
  28. pmc The TRPV4 channel contributes to intercellular junction formation in keratinocytes
    Takaaki Sokabe
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    J Biol Chem 285:18749-58. 2010
    ..Our results suggest a novel role for TRPV4 in the development and maturation of cell-cell junctions in epithelia of the skin...
  29. pmc Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions
    Makiko Kashio
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    Proc Natl Acad Sci U S A 109:6745-50. 2012
    ..Our results suggest that TRPM2 sensitization plays important roles in macrophage functions...
  30. pmc DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze
    Suhail Asrar
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience National Institute for Physiological Sciences, Japan
    Mol Brain 4:39. 2011
    ....
  31. doi request reprint Drosophila painless is a Ca2+-requiring channel activated by noxious heat
    Takaaki Sokabe
    Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    J Neurosci 28:9929-38. 2008
    ..Our results demonstrate that Painless is a direct sensor for noxious heat in Drosophila...
  32. pmc Intracellular alkalization causes pain sensation through activation of TRPA1 in mice
    Fumitaka Fujita
    Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institute of Natural Sciences, Okazaki, Japan
    J Clin Invest 118:4049-57. 2008
    ..These results suggest that alkaline pH causes pain sensation through activation of TRPA1 and may provide a molecular explanation for some of the human alkaline pH-related sensory disorders whose mechanisms are largely unknown...
  33. doi request reprint DIP/WISH-deficient mice reveal Dia- and N-WASP-interacting protein as a regulator of cytoskeletal dynamics in embryonic fibroblasts
    Tomoko Fukumi-Tominaga
    Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    Genes Cells 14:1197-207. 2009
    ..Thus, DIP/WISH is a negative regulator of Rho and modulates cell adhesion by controlling the integration of adhesion molecules...
  34. doi request reprint Heat and noxious chemical sensor, chicken TRPA1, as a target of bird repellents and identification of its structural determinants by multispecies functional comparison
    Shigeru Saito
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience National Institute for Physiological Sciences, National Institute of Natural Sciences, Okazaki, Aichi, Japan
    Mol Biol Evol 31:708-22. 2014
    ..Furthermore, TRPA1 responses to MA varied among five diverse vertebrate species. Utilizing species diversity and mutagenesis experiments, three amino acids were identified as critical residues for MA-induced activation of chicken TRPA1. ..
  35. pmc 1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1
    Masayuki Takaishi
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, 444 8787, Japan
    Mol Pain 8:86. 2012
    ..TRPM8 is a thermosensitive receptor that detects cool temperatures and menthol whereas TRPA1 is a sensor of noxious cold. Ideally, an effective analgesic compound would activate TRPM8 and inhibit TRPA1...
  36. doi request reprint Long-lasting silencing of orexin/hypocretin neurons using archaerhodopsin induces slow-wave sleep in mice
    Tomomi Tsunematsu
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, Okazaki 444 8787, Japan The Japan Society for the Promotion of Sciences, Tokyo 102 8472, Japan
    Behav Brain Res 255:64-74. 2013
    ..These results suggest that orexin neuronal activity plays a crucial role in the maintenance of wakefulness especially in the active phase in mice. ..
  37. doi request reprint Isothiocyanates from Wasabia japonica activate transient receptor potential ankyrin 1 channel
    Kunitoshi Uchida
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Aichi 444 8787, Japan
    Chem Senses 37:809-18. 2012
    ..These results indicate the following: 1) 6-MSITC and 6-MTITC activate both mTRPA1 and hTRPA1; 2) 6-MSITC activates mTRPV1; and 3) the pharmacological functions of these isothiocyanates could be derived from TRPA1 activation...
  38. doi request reprint Orexin directly excites orexin neurons through orexin 2 receptor
    Akihiro Yamanaka
    Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institute of Natural Sciences, Okazaki 444 8787, Japan
    J Neurosci 30:12642-52. 2010
    ..Therefore, the activation of orexin neurons through OX2R might have an important role in the maintenance of arousal...
  39. pmc Extracellular zinc ion regulates transient receptor potential melastatin 5 (TRPM5) channel activation through its interaction with a pore loop domain
    Kunitoshi Uchida
    Division of Cell Signaling, National Institute for Physiological Sciences Okazaki Institutes for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    J Biol Chem 288:25950-5. 2013
    ..From these results, we conclude that extracellular Zn(2+) inhibits TRPM5 channels, and the residues in the outer pore loop of TRPM5 are critically involved in the inhibition...
  40. pmc Off-response property of an acid-activated cation channel complex PKD1L3-PKD2L1
    Hitoshi Inada
    Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, Higashiyama 5 1, Myodaiji, Okazaki, Aichi 444 8787, Japan
    EMBO Rep 9:690-7. 2008
    ..The off-response property of PKD1L3-PKD2L1 channels might explain the physiological phenomena occurring during sour taste sensation...
  41. pmc TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion
    Kazuya Togashi
    Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Aichi, Japan
    EMBO J 25:1804-15. 2006
    ....
  42. ncbi request reprint The role of thermosensitive TRP (transient receptor potential) channels in insulin secretion
    Kunitoshi Uchida
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience National Institute for Physiological Sciences, National Institutes of Natural Sciences, Aichi 444 8787 Japan
    Endocr J 58:1021-8. 2011
    ....
  43. doi request reprint TRPV2 enhances axon outgrowth through its activation by membrane stretch in developing sensory and motor neurons
    Koji Shibasaki
    Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    J Neurosci 30:4601-12. 2010
    ..Thus, for the first time we revealed that TRPV2 is an important regulator for axon outgrowth through its activation by membrane stretch during development...
  44. pmc Analysis of transient receptor potential ankyrin 1 (TRPA1) in frogs and lizards illuminates both nociceptive heat and chemical sensitivities and coexpression with TRP vanilloid 1 (TRPV1) in ancestral vertebrates
    Shigeru Saito
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience National Institute for Physiological Sciences, National Institute of Natural Sciences, Okazaki, Aichi, 444 8787, Japan
    J Biol Chem 287:30743-54. 2012
    ..In addition, our results also demonstrated that two mammalian TRPA1 inhibitors elicited different effect on the TRPA1s of WC frogs and green anoles, which can be utilized to clarify the structural bases for inhibition of TRPA1...
  45. ncbi request reprint [Molecular mechanisms underlying thermosensation in mammals]
    Takaaki Sokabe
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience National Institute for Physiological Sciences, National Institutes of Natural Sciences, Higashiyama 5 1, Myodaiji cho, Okazaki, Aichi 444 8787, Japan
    Brain Nerve 61:867-73. 2009
    ..In this review, I summarize the molecular mechanisms of thermosensation in mammals by focusing on thermosensitive TRP channels...
  46. doi request reprint Incubation type Si-based planar ion channel biosensor
    Tsuneo Urisu
    Institute for Molecular Science, Myodaiji, Okazaki, 444 8585, Japan
    Anal Bioanal Chem 391:2703-9. 2008
    ....
  47. ncbi request reprint Potential role of transient receptor potential (TRP) channels in bladder cancer cells
    Hideki Mizuno
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience National Institute for Physiological Sciences, National Institutes of Natural Sciences, 5 1 Higashiyama, Myodaiji, Okazaki, 444 8787, Japan
    J Physiol Sci 64:305-14. 2014
    ..These results suggested that TRPV2 and TRPM7 were functionally expressed in bladder cancer cells and served as negative regulators of bladder cancer cell proliferation, most likely to prevent excess mechanical stresses. ..
  48. ncbi request reprint Different expression patterns of TRP genes in murine B and T lymphocytes
    Hitoshi Inada
    Section of Cell Signaling, Department of Bio environmental Science, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Science, Higashiyama 5 1, Myodaiji, Okazaki, Aichi 444 8787, Japan
    Biochem Biophys Res Commun 350:762-7. 2006
    ..RT-PCR analysis revealed different expression patterns of the TRP channel genes in B and T lymphocytes isolated from the spleen. Therefore, our results provide an appropriate reference of TRP gene expression in murine lymphocytes...
  49. pmc Evolution of vertebrate transient receptor potential vanilloid 3 channels: opposite temperature sensitivity between mammals and western clawed frogs
    Shigeru Saito
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Aichi, Japan
    PLoS Genet 7:e1002041. 2011
    ....
  50. ncbi request reprint TRPM2 modulates insulin secretion in pancreatic β-cells
    Kunitoshi Uchida
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institute of Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Aichi, Japan
    Islets 3:209-11. 2011
    ..Although further examination is needed to clarify the mechanism of TRPM2-mediated insulin secretion, TRPM2 may be a key player in regulation of insulin secretion and could represent a new target for diabetes therapy...
  51. ncbi request reprint [Capsaicin receptor TRPV1]
    Makoto Tominaga
    Section of Cell Signaling, Okazaki Institute for Integrative Bioscience National Institute for Physiological Sciences, National Institutes of Natural Sciences, Higashiyama 5 1, Myodaiji, Okazaki, Aichi 444 8787, Japan
    Brain Nerve 60:493-501. 2008
    ..Furthermore, several clinical trials involving the use of TRPV1 antagonists as analgesic agents are currently underway. With success, some of these agents may enter the market in the near future...
  52. ncbi request reprint Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues
    Mitsuko Numazaki
    Department of Physiology, Mie University School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    J Biol Chem 277:13375-8. 2002
    ..The two sites would be promising targets for the development of substance modulating VR1 function, thereby reducing pain...
  53. ncbi request reprint Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain
    Yi Dai
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo 663 8501, Japan
    J Neurosci 24:4293-9. 2004
    ..These represent a novel mechanism through which trypsin or tryptase released in response to tissue inflammation might trigger the sensation of pain by PAR2 activation...
  54. ncbi request reprint [Function of TRP channel as a thermal receptor]
    Makoto Tominaga
    Nihon Seirigaku Zasshi 65:130-7. 2003
  55. ncbi request reprint Nociception and TRP Channels
    Mitsuko Numazaki
    Department of Anesthesiology, University of Tsukuba School of Medicine, Tsukuba 305 0006, Japan
    Curr Drug Targets CNS Neurol Disord 3:479-85. 2004
    ..Some of the thermosensitive TRP channels are likely to be involved in thermal nociception, since their activation thresholds are within the noxious range of temperatures...
  56. ncbi request reprint Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity
    Tomoko Moriyama
    Department of Cellular and Molecular Physiology, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    J Neurosci 23:6058-62. 2003
    ..These data indicate the importance of metabotropic P2Y2 receptors in nociception through TRPV1...
  57. pmc TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury
    Koichi Obata
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, Japan
    J Clin Invest 115:2393-401. 2005
    ..Thus, blocking TRPA1 in sensory neurons might provide a fruitful strategy for treating cold hyperalgesia caused by inflammation and nerve damage...
  58. ncbi request reprint [Molecular mechanisms of nociception and thermosensation: structures, expressions and functions of capsaicin receptor and its homologues]
    Mitsuko Numazaki
    Mie University School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    Seikagaku 75:359-71. 2003
  59. pmc Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain
    Yi Dai
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo, Japan
    J Clin Invest 117:1979-87. 2007
    ....
  60. ncbi request reprint Heat-evoked activation of the ion channel, TRPV4
    Ali Deniz Güler
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 22:6408-14. 2002
    ..Together, these data implicate TRPV4 as a possible transducer of warm stimuli within the hypothalamus...
  61. doi request reprint Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain
    Shenglan Wang
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Brain 131:1241-51. 2008
    ..Collectively, these results represent a novel mechanism through which bradykinin released in response to tissue inflammation might trigger the sensation of pain by TRPA1 activation...
  62. ncbi request reprint [Molecular mechanisms of nociception]
    Makoto Tominaga
    Department of Cellular and Molecular Physiology, Mie University School of Medicine, 2 174, Edobashi, Tsu, 514 8507 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 23:139-47. 2003
    ..This represents a novel mechanism through which ATP or bradykinin in response to tissue trauma might trigger the sensation of pain...
  63. pmc Structural determinant of TRPV1 desensitization interacts with calmodulin
    Mitsuko Numazaki
    Department of Cellular and Molecular Physiology, Mie University School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    Proc Natl Acad Sci U S A 100:8002-6. 2003
    ..Compounds that interfere with the 35-aa segment could therefore prove useful in the treatment of pain...
  64. ncbi request reprint Decreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Japanese Population: the Funagata study
    Makoto Daimon
    Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Diabetes Care 26:2015-20. 2003
    ..To examine whether decreased serum levels of adiponectin are an independent risk factor for the progression to type 2 diabetes in a Japanese population...
  65. ncbi request reprint Large-scale search of SNPs for type 2 DM susceptibility genes in a Japanese population
    Makoto Daimon
    The Third Department of Internal Medicine, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Biochem Biophys Res Commun 302:751-8. 2003
    ..Six genes (met proto-oncogene, ATP-binding cassette transporter A1, fatty acid binding protein 2, LDL receptor defect C complementing, aldolase B, and sulfonylurea receptor) were shown to be associated with DM...
  66. ncbi request reprint Local inflammation increases vanilloid receptor 1 expression within distinct subgroups of DRG neurons
    Fumimasa Amaya
    Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kamikyo ku, Kyoto, Japan
    Brain Res 963:190-6. 2003
    ..Local inflammation thus increases in VR1 protein level within distinct subgroups of DRG neurons that may participate in the development and maintenance of inflammatory hyperalgesia...
  67. ncbi request reprint Bradykinin lowers the threshold temperature for heat activation of vanilloid receptor 1
    Takeshi Sugiura
    Department of Anesthesiology and Resuscitology, Nagoya City University Medical School, Nagoya 467 0001, Japan
    J Neurophysiol 88:544-8. 2002
    ..These data further support the supposition that modulation of VR1 is a mechanism for the BK-induced excitation of nociceptors and their sensitization to heat...
  68. pmc DIP (mDia interacting protein) is a key molecule regulating Rho and Rac in a Src-dependent manner
    Wenxiang Meng
    Department of Cellular and Molecular Physiology, Mie University School of Medicine, Tsu, Japan
    EMBO J 23:760-71. 2004
    ..Thus, DIP acts as a regulatory molecule causing Src kinase-dependent feedback modulation of Rho GTPases downstream of Rho-mDia upon EGF stimulation, and plays an important role in cell motility...
  69. ncbi request reprint Activation of protein kinase C reverses capsaicin-induced calcium-dependent desensitization of TRPV1 ion channels
    Sravan Mandadi
    Faculty of Pharmacy, Bldg A 15, Science Road, University of Sydney, NSW 2006, Australia
    Cell Calcium 35:471-8. 2004
    ..This study provides evidence for a role of PKC in reversing capsaicin-induced calcium-dependent desensitization of TRPV1 ion channels...
  70. ncbi request reprint The metabolic syndrome identifies a heterogeneous group of metabolic component combinations in the Asia-Pacific region
    Crystal Man Ying Lee
    The George Institute for International Health, University of Sydney, Sydney, NSW 2050, Australia
    Diabetes Res Clin Pract 81:377-80. 2008
    ..To compare the prevalence of metabolic syndrome (MetS) by combinations of MetS components derived from the National Cholesterol Education Program Adult Treatment Panel III (ATPIII) and International Diabetes Federation (IDF) definitions...
  71. ncbi request reprint Characterization of activation of MAP kinase superfamily in vasculature from diabetic rats
    Masahiko Igarashi
    Department of Laboratory Medicine, Yamagata University School of Medicine, Yamagata, Japan
    J Atheroscler Thromb 14:235-44. 2007
    ..This study was investigated to characterize the activation mechanism of a mitogen-activated protein (MAP) kinase superfamily in diabetes in aortae and cultured vascular smooth muscle cells (VSMCs) from rats...
  72. ncbi request reprint Effect of pioglitazone on atherogenic outcomes in type 2 diabetic patients: a comparison of responders and non-responders
    Masahiko Igarashi
    Department of Laboratory Medicine, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Diabetes Res Clin Pract 77:389-98. 2007
    ..These results strongly suggest that pioglitazone is beneficial for type 2 diabetic patients with high levels of BMI, HOMA-IR, LDL-C, and RLP-C, as it helps to prevent the progression of atherosclerosis, including coronary heart diseases...
  73. ncbi request reprint Effects of skin surface temperature on epidermal permeability barrier homeostasis
    Mitsuhiro Denda
    Shiseido Research Center, Kanazawa Ku, Yokohama, Japan
    J Invest Dermatol 127:654-9. 2007
    ..Previous reports suggest the existence of a water flux sensor in the epidermis, and as TRPV4 is known to be activated by osmotic pressure, our results indicate that it might be this sensor...
  74. ncbi request reprint Lipophilicity of capsaicinoids and capsinoids influences the multiple activation process of rat TRPV1
    Akihito Morita
    School of Food and Nutritional Sciences and COE Program in the 21st Century, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Life Sci 79:2303-10. 2006
    ..These results suggest that highly lipophilic compounds cause only a slight Ca2+ influx, via TRPV1 in the plasma membrane, and are not able to activate TRPV1 in the endoplasmic reticulum...
  75. pmc Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor
    Yoshiro Ishimaru
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 103:12569-74. 2006
    ..Finally, PKD1L3 and PKD2L1 are activated by various acids when coexpressed in heterologous cells but not by other classes of tastants. These results suggest that PKD1L3 and PKD2L1 heteromers may function as sour taste receptors...
  76. ncbi request reprint Increased sensitivity of desensitized TRPV1 by PMA occurs through PKCepsilon-mediated phosphorylation at S800
    Sravan Mandadi
    Faculty of Pharmacy, University of Sydney, NSW 2006, Australia
    Pain 123:106-16. 2006
    ..This study, therefore, identifies PKCepsilon and S800 as important therapeutic targets that may help regulate inhibitory effects on TRPV1 and hence its desensitization...
  77. ncbi request reprint [Pain and Bradykinin Receptors--sensory transduction mechanism in the nociceptor terminals and expression change of bradykinin receptors in inflamed condition]
    Kazue Mizumura
    Department of Neural Regulation, Research Institute of Environmental Medicine, Nagoya University, Nagoya, 464 8601, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 25:33-8. 2005
    ..In addition nociceptor sensitivity to BK was augmented in inflamed animals, with B2R mRNA and protein upregulated. The mechanism for prostaglandin-induced augmentation of BK response is left open for future study...
  78. ncbi request reprint Altered PDGF-BB-induced p38 MAP kinase activation in diabetic vascular smooth muscle cells: roles of protein kinase C-delta
    Hiroshi Yamaguchi
    Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan
    Arterioscler Thromb Vasc Biol 24:2095-101. 2004
    ..We investigated the regulation of p38 mitogen-activated protein kinase (MAPK) by platelet-derived growth factor (PDGF)-BB and its biological effects in cultured normal and diabetic rat vascular smooth muscle cells (VSMCs)...
  79. ncbi request reprint Nitric oxide activates TRP channels by cysteine S-nitrosylation
    Takashi Yoshida
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615 8510, Japan
    Nat Chem Biol 2:596-607. 2006
    ..These findings reveal the structural motif for the NO-sensitive activation gate in TRP channels and indicate that NO sensors are a new functional category of cellular receptors extending over different TRP families...