Yasushi Toh

Summary

Affiliation: National Kyushu Cancer Center
Country: Japan

Publications

  1. doi request reprint Epigenetic alterations and their clinical implications in esophageal squamous cell carcinoma
    Yasushi Toh
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka, 811 1395, Japan
    Gen Thorac Cardiovasc Surg 61:262-9. 2013
  2. ncbi request reprint Molecular analysis of a candidate metastasis-associated gene, MTA1: possible interaction with histone deacetylase 1
    Y Toh
    Dept of Gastroenterologic Surgery, National Kyushu Cancer Center, Fukuoka, Japan
    J Exp Clin Cancer Res 19:105-11. 2000
  3. ncbi request reprint Treatment results of radical surgery and definitive chemoradiotherapy for patients with submucosal esophageal squamous cell cancinomas
    Yasushi Toh
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka, 811 1395, Japan
    Anticancer Res 26:2487-91. 2006
  4. doi request reprint The role of the MTA family and their encoded proteins in human cancers: molecular functions and clinical implications
    Yasushi Toh
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka, Japan
    Clin Exp Metastasis 26:215-27. 2009
  5. ncbi request reprint Expression of the metastasis-associated MTA1 protein and its relationship to deacetylation of the histone H4 in esophageal squamous cell carcinomas
    Yasushi Toh
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, Fukuoka, Japan
    Int J Cancer 110:362-7. 2004
  6. doi request reprint Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: molecular mechanisms of carcinogenesis
    Yasushi Toh
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka 811 1395, Japan
    Int J Clin Oncol 15:135-44. 2010
  7. ncbi request reprint End-to-end anastomosis using a surgical instrument after a segmental resection of the distal duodenum
    Yasushi Toh
    Department of Gastroenterologic Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka 811 1395, Japan
    J Surg Oncol 85:88-90. 2004
  8. ncbi request reprint Histone H4 acetylation and histone deacetylase 1 expression in esophageal squamous cell carcinoma
    Yasushi Toh
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, Fukuoka 811 1395, Japan
    Oncol Rep 10:333-8. 2003
  9. ncbi request reprint Reduced expression of manganese superoxide dismutase mRNA may correlate with invasiveness in esophageal carcinoma
    Y Toh
    Department of Gastroenterologic Surgery, National Kyushu Cancer Center, Fukuoka, Japan
    Oncology 59:223-8. 2000
  10. ncbi request reprint Prognostic significance of tumor markers in peritoneal lavage in advanced gastric cancer
    Manabu Yamamoto
    Department of Gastroenterologic Surgery, Kyushu Cancer Center, Fukuoka, Japan
    Oncology 67:19-26. 2004

Detail Information

Publications39

  1. doi request reprint Epigenetic alterations and their clinical implications in esophageal squamous cell carcinoma
    Yasushi Toh
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka, 811 1395, Japan
    Gen Thorac Cardiovasc Surg 61:262-9. 2013
    ..Clinical implications of these epigenetic alterations in ESCC will be also discussed...
  2. ncbi request reprint Molecular analysis of a candidate metastasis-associated gene, MTA1: possible interaction with histone deacetylase 1
    Y Toh
    Dept of Gastroenterologic Surgery, National Kyushu Cancer Center, Fukuoka, Japan
    J Exp Clin Cancer Res 19:105-11. 2000
    ....
  3. ncbi request reprint Treatment results of radical surgery and definitive chemoradiotherapy for patients with submucosal esophageal squamous cell cancinomas
    Yasushi Toh
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka, 811 1395, Japan
    Anticancer Res 26:2487-91. 2006
    ..However, the treatment outcomes have not yet been extensively investigated...
  4. doi request reprint The role of the MTA family and their encoded proteins in human cancers: molecular functions and clinical implications
    Yasushi Toh
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka, Japan
    Clin Exp Metastasis 26:215-27. 2009
    ..MTA proteins are proposed to be important new tools for clinical application in cancer diagnosis and treatment...
  5. ncbi request reprint Expression of the metastasis-associated MTA1 protein and its relationship to deacetylation of the histone H4 in esophageal squamous cell carcinomas
    Yasushi Toh
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, Fukuoka, Japan
    Int J Cancer 110:362-7. 2004
    ..Thus, strategies involving inhibition of MTA1 function as well as inhibition of histone deacetylation could be novel approaches for the treatment of esophageal squamous cell carcinomas...
  6. doi request reprint Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: molecular mechanisms of carcinogenesis
    Yasushi Toh
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka 811 1395, Japan
    Int J Clin Oncol 15:135-44. 2010
    ..This brief review summarizes the general mechanisms of alcohol- and smoking-induced carcinogenesis and then discusses the mechanisms of the development of ESCC, with special attention to alcohol consumption and cigarette smoking...
  7. ncbi request reprint End-to-end anastomosis using a surgical instrument after a segmental resection of the distal duodenum
    Yasushi Toh
    Department of Gastroenterologic Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka 811 1395, Japan
    J Surg Oncol 85:88-90. 2004
  8. ncbi request reprint Histone H4 acetylation and histone deacetylase 1 expression in esophageal squamous cell carcinoma
    Yasushi Toh
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, Fukuoka 811 1395, Japan
    Oncol Rep 10:333-8. 2003
    ....
  9. ncbi request reprint Reduced expression of manganese superoxide dismutase mRNA may correlate with invasiveness in esophageal carcinoma
    Y Toh
    Department of Gastroenterologic Surgery, National Kyushu Cancer Center, Fukuoka, Japan
    Oncology 59:223-8. 2000
    ....
  10. ncbi request reprint Prognostic significance of tumor markers in peritoneal lavage in advanced gastric cancer
    Manabu Yamamoto
    Department of Gastroenterologic Surgery, Kyushu Cancer Center, Fukuoka, Japan
    Oncology 67:19-26. 2004
    ..The predictive value of the levels of tumor markers in peritoneal lavage for peritoneal metastasis from gastric carcinoma was thus studied...
  11. doi request reprint Lymph node metastasis from cancer of the esophagogastric junction, and determination of the appropriate nodal dissection
    Yoshihiro Kakeji
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, 812 8582, Japan
    Surg Today 42:351-8. 2012
    ..Both squamous cell carcinomas and adenocarcinomas can develop in the esophagogastric junction. To clarify the appropriate lymph node dissection range, lymph node metastases from cancers in the esophagogastric junction were investigated...
  12. doi request reprint Clinical results of definitive chemoradiotherapy for patients with synchronous head and neck squamous cell carcinoma and esophageal cancer
    Makoto Shinoto
    Department of Radiology, National Kyushu Cancer Center, Fukuoka, Japan
    Am J Clin Oncol 34:362-6. 2011
    ..To assess the efficacy and toxicity of radical chemoradiotherapy for patients with synchronous head and neck squamous cell carcinoma (HNSCC) and esophageal cancer (EC)...
  13. doi request reprint Advantages of totally laparoscopic distal gastrectomy over laparoscopically assisted distal gastrectomy for gastric cancer
    Osamu Ikeda
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, Notame 3 1 1, Minami Ku, Fukuoka, 811 1395, Japan
    Surg Endosc 23:2374-9. 2009
    ..Although laparoscopically assisted distal gastrectomy (LADG) has several advantages over open distal gastrectomy, little has been reported about the safety and feasibility of totally laparoscopic distal gastrectomy (TLDG)...
  14. doi request reprint Clinical characteristics of gastric cancer with metastasis to the lymph node along the superior mesenteric vein (14v)
    Taka aki Masuda
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, Minami Ku, Fukuoka, Japan
    Dig Surg 25:351-8. 2008
    ..We investigated the clinical significance of metastasis to the lymph node (LN) along the superior mesenteric vein (14v) in gastric cancer...
  15. ncbi request reprint Clinical efficacy of S-1 combined with cisplatin for advanced gastric cancer
    Hideo Baba
    Department of Gastroenterologic Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka 811 1395, Japan
    Gastric Cancer 6:45-9. 2003
    ..Further study with a large number of patients may be needed to confirm the combination of S-1 and CDDP to be an appropriate first-line chemotherapy for gastric cancer...
  16. doi request reprint Multiple and metachronous esophageal intramural metastases from a gastric adenocarcinoma
    Osamu Ikeda
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka 811 1395, Japan
    Gastric Cancer 11:119-22. 2008
    ..Esophageal intramural metastases from a gastric cancer imply a systemic expansion of the gastric cancer, and portend a poor prognosis...
  17. doi request reprint Evaluation of oncological adequacy of laparoscopic distal gastrectomy with special attention to lymph node dissection: a comparison with conventional open gastrectomy
    Osamu Ikeda
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, Fukuoka, Japan
    Hepatogastroenterology 59:627-32. 2012
    ..Laparoscopic distal gastrectomy (LDG) with lymphadenectomy has been revealed to be a useful treatment for early gastric cancer but oncological adequacy is controversial...
  18. doi request reprint Long-term survival following radical surgery after chemotherapy for esophagogastric adenocarcinoma with extensive lymph node metastases: report of a case
    Yoshiro Aoki
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka, 811 1395, Japan
    Surg Today 41:1255-9. 2011
    ..Finally, we performed transthoracic subtotal esophagectomy with extensive lymph node dissection reconstructed using a gastric tube through a retrosternal route. The patient remains recurrence-free 7 years later...
  19. doi request reprint Risk factors for early recurrence after curative hepatectomy for colorectal liver metastases
    Yo ichi Yamashita
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka, 811 1395, Japan
    Surg Today 41:526-32. 2011
    ..The aim of this study is to identify risk factors of early recurrence, defined as recurrence within 1 year after surgery...
  20. doi request reprint The triangulating stapling technique for cervical esophagogastric anastomosis after esophagectomy
    Yasushi Toh
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka, 811 1395, Japan
    Surg Today 39:201-6. 2009
    ..To evaluate the safety and feasibility of the triangulating stapling technique (TST) for cervical esophagogastric anastomosis after esophagectomy (CEGA)...
  21. ncbi request reprint Postoperative morbidity/mortality and survival rates after total gastrectomy, with splenectomy/pancreaticosplenectomy for patients with advanced gastric cancer
    Manabu Yamamoto
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, Fukuoka, Japan
    Hepatogastroenterology 51:298-302. 2004
    ..We investigated characteristic findings in patients with lymph node metastasis to the splenic hilus and the indication of splenectomy with total gastectomy for T2 and T3 advanced gastric cancer...
  22. doi request reprint Gastric cancer in the reconstructed gastric tube after radical esophagectomy: a single-center experience
    Eiji Oki
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka, 811 1395, Japan
    Surg Today 41:966-9. 2011
    ..This study investigated 10 cases of gastric tube cancer in order to clarify the characteristics and the outcome of these patients...
  23. doi request reprint Surgical complications and the risk factors of totally laparoscopic distal gastrectomy
    Eiji Oki
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, Nodame, Minami Ku, Japan
    Surg Laparosc Endosc Percutan Tech 21:146-50. 2011
    ..It has not yet been elucidated whether there are specific complications associated with totally laparoscopic distal gastrectomy (TLDG). We evaluated the complications and the risk factors associated with TLDG...
  24. doi request reprint New technique for the retraction of the liver in laparoscopic gastrectomy
    Yoshihisa Sakaguchi
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka, 811 1395, Japan
    Surg Endosc 22:2532-4. 2008
    ..We developed a new technique for the retraction of the liver using a Penrose drain and a J-shaped retractor, which is both an easy and time-saving method that provides a good view during laparoscopic gastrectomy without damaging the liver...
  25. doi request reprint Surgical indications for gastrectomy combined with distal or partial pancreatectomy in patients with gastric cancer
    Yasuo Sakamoto
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka, 811 1395, Japan
    World J Surg 36:2412-9. 2012
    ..The purpose of this study was to clarify the surgical indications for gastrectomy combined with distal or partial pancreatectomy (GP) in patients with gastric cancer...
  26. doi request reprint The significance of fibroblast growth factor receptor 2 expression in differentiation of hepatocellular carcinoma
    Norifumi Harimoto
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, Fukuoka, Japan
    Oncology 78:361-8. 2010
    ..These data suggest that FGFR2 may be a potentially useful biological marker of tumor invasiveness in HCC as well as a novel molecular target for HCC...
  27. doi request reprint Safe laparoscopic resection of a gastric gastrointestinal stromal tumor close to the esophagogastric junction
    Yasuo Sakamoto
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka, 811 1395, Japan
    Surg Today 42:708-11. 2012
    ..Five patients with GIST close to EGJ underwent this procedure, followed by a good postoperative course. Thus, we consider our procedure to be safe and effective for gastric GISTs close to the EGJ...
  28. pmc The impact of obesity on the use of a totally laparoscopic distal gastrectomy in patients with gastric cancer
    Eiji Oki
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Gastric Cancer 12:108-12. 2012
    ..This study evaluated the feasibility of performing a totally laparoscopic distal gastrectomy, with intracorporeal anastomosis, in obese patients suffering from gastric cancer...
  29. doi request reprint Surgical outcomes after resection of both hepatic and pulmonary metastases from colorectal cancer
    Yasuo Sakamoto
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka 811 1395, Japan
    World J Surg 36:2708-13. 2012
    ..This study retrospectively reviewed the cases of CRC patients who underwent both liver and lung resection to define the appropriate indications for surgical resection in patients with hepatic and pulmonary metastases...
  30. doi request reprint Soft coagulation, polyglycolic acid felt, and fibrin glue for prevention of pancreatic fistula after distal pancreatectomy
    Toru Ikegami
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Surg Today 41:1224-7. 2011
    ..To evaluate the effectiveness of using soft coagulation followed by the application of polyglycolic acid (PGA) felt and fibrin glue to prevent pancreatic fistula (PF) after distal pancreatectomy (DP)...
  31. pmc Totally Laparoscopic Gastrectomy for Gastric Cancer Associated with Recklinghausen's Disease
    Yoshihisa Sakaguchi
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka 811 1395, Japan
    Diagn Ther Endosc 2010:682401. 2010
    ..Since the totally laparoscopic gastrectomy has many advantages over open surgery, it should therefore be preferentially used as a less invasive treatment in the field of gastric cancer...
  32. doi request reprint Superdrainage of the ileocolic vein to the internal jugular vein interposed by an inferior mesenteric vein graft in replacing the esophagus with the right hemicolon
    Hideaki Uchiyama
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Surg Today 40:578-82. 2010
    ..Superdrainage of the ileocolic vein to the internal jugular vein interposed by an IMV graft effectively improves the blood circulation in intestinal conduits brought up to the neck as an esophageal replacement...
  33. ncbi request reprint Protracted hepatic arterial infusion with low-dose cisplatin plus 5-fluorouracil for unresectable liver metastases from colorectal cancer
    Shunji Kohnoe
    National Kyushu Cancer Center and the Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Surgery 131:S128-34. 2002
    ..The aims of this study were to demonstrate the efficacy of protracted HAI chemotherapy with low-dose cisplatin plus 5-fluorouracil for patients with unresectable liver metastases from colorectal cancer...
  34. ncbi request reprint Overt lymph node metastases from a gastrointestinal stromal tumor of the esophagus
    Takaaki Masuda
    Department of Gastroenterogical Surgery, National Kyushu Cancer Center, Fukuoka, Japan
    J Thorac Cardiovasc Surg 134:810-1. 2007
  35. ncbi request reprint Endoscopic mucosal resection for early cardia cancer by minimum laparotomy
    Kazuya Endo
    Department of Gastroenterologic Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka 811 1395, Japan
    Am J Surg 185:285-7. 2003
    ..We report here a new approach to EMR for early cancers of the cardia located close to the esophagocardia junction that are outside the indications for ordinary EMR...
  36. ncbi request reprint Treatment outcomes of radiotherapy for patients with stage I esophageal cancer: a single institute experience
    Tomonari Sasaki
    Department of Radiology, National Kyushu Cancer Center, Fukuoka, Japan
    Am J Clin Oncol 30:514-9. 2007
    ..To evaluate the effectiveness of radiotherapy for patients with stage I esophageal cancer...
  37. ncbi request reprint Identification and characterization of the variants of metastasis-associated protein 1 generated following alternative splicing
    Masahiro Yaguchi
    Institute for Clinical Research, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka 811 1395, Japan
    Biochim Biophys Acta 1732:8-14. 2005
    ..Knowledge of the Mta1 gene expression pattern will be useful in better understanding its functional diversity...
  38. ncbi request reprint Direct interaction between metastasis-associated protein 1 and endophilin 3
    Yuko Aramaki
    Institute for Clinical Research, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka 811 1395, Japan
    FEBS Lett 579:3731-6. 2005
    ..But, Mta1 localized mainly in nucleus and to a lesser extent in cytoplasm while endophilin 3 localized mainly in cytoplasm. If Mta1 functions in cytoplasm, it might be involved in the regulation of endocytosis mediated by endophilin 3...
  39. ncbi request reprint [Reoperation for the reconstruction organ necrosis after esophagectomy]
    Akinori Egashira
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, Fukuoka, Japan
    Kyobu Geka 66:767-71. 2013
    ..Here, we will summarize the way of diagnosis and treatment for the necrosis of reconstructed organs and present 2 cases of reconstruction organ necrosis (gastric tube and ascending colon) after esophagectomy in our institute. ..