Hiroshi Tanahashi

Summary

Affiliation: National Institute of Neuroscience
Country: Japan

Publications

  1. ncbi request reprint Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Hum Mol Genet 9:2281-9. 2000
  2. ncbi request reprint Association between tau polymorphism and male early-onset Alzheimer's disease
    Hiroshi Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neuroreport 15:175-9. 2004
  3. pmc Characterization of an amyloid precursor protein-binding protein Fe65L2 and its novel isoforms lacking phosphotyrosine-interaction domains
    Hiroshi Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Biochem J 367:687-95. 2002
  4. ncbi request reprint Three novel alternatively spliced isoforms of the human beta-site amyloid precursor protein cleaving enzyme (BACE) and their effect on amyloid beta-peptide production
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurosci Lett 307:9-12. 2001
  5. ncbi request reprint A novel beta-site amyloid precursor protein cleaving enzyme (BACE) isoform regulated by nonsense-mediated mRNA decay and proteasome-dependent degradation
    Hiroshi Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurosci Lett 428:103-8. 2007
  6. ncbi request reprint Genomic organization of the human X11L2 gene (APBA3), a third member of the X11 protein family interacting with Alzheimer's beta-amyloid precursor protein
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, Kodaira, Tokyo, Japan
    Neuroreport 10:2575-8. 1999
  7. ncbi request reprint Cloning of the cDNA encoding rat presenilin-2
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, Tokyo, Japan
    Biochim Biophys Acta 1396:259-62. 1998
  8. ncbi request reprint Genome structure and chromosomal mapping of the gene for Fe65L2 interacting with Alzheimer's beta-amyloid precursor protein
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, 187 8502, Japan
    Biochem Biophys Res Commun 258:385-9. 1999
  9. ncbi request reprint Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, Tokyo, Japan
    Neurosci Lett 261:143-6. 1999
  10. ncbi request reprint X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Tokyo, Kodaira, 187 8502, Japan
    Biochem Biophys Res Commun 255:663-7. 1999

Detail Information

Publications13

  1. ncbi request reprint Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Hum Mol Genet 9:2281-9. 2000
    ..The potential role of DRAL in the cellular signaling suggests that DRAL functions as an adaptor protein that links PS2 to an intracellular signaling...
  2. ncbi request reprint Association between tau polymorphism and male early-onset Alzheimer's disease
    Hiroshi Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neuroreport 15:175-9. 2004
    ..30-5.42), suggesting that age and gender modify the risk effect. However, we failed to replicate the reported association between the Saitohin gene located in the tau intron 9 and Japanese Alzheimer's disease...
  3. pmc Characterization of an amyloid precursor protein-binding protein Fe65L2 and its novel isoforms lacking phosphotyrosine-interaction domains
    Hiroshi Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Biochem J 367:687-95. 2002
    ..These results suggest that Fe65L2 affects Abeta production and a possible regulation of Fe65L2 function by alternative splicing...
  4. ncbi request reprint Three novel alternatively spliced isoforms of the human beta-site amyloid precursor protein cleaving enzyme (BACE) and their effect on amyloid beta-peptide production
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurosci Lett 307:9-12. 2001
    ..Moreover, the beta-secretase activity of BACE-I-457 and BACE-I-476 was significantly weaker than that of BACE-501. Thus, these isoforms may contribute to a physiological function of BACE...
  5. ncbi request reprint A novel beta-site amyloid precursor protein cleaving enzyme (BACE) isoform regulated by nonsense-mediated mRNA decay and proteasome-dependent degradation
    Hiroshi Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurosci Lett 428:103-8. 2007
    ..Finally, I-127 was degraded in a proteasome-dependent manner. Thus, I-127 is regulated by both nonsense-mediated mRNA decay (NMD) and proteasome-dependent degradation...
  6. ncbi request reprint Genomic organization of the human X11L2 gene (APBA3), a third member of the X11 protein family interacting with Alzheimer's beta-amyloid precursor protein
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, Kodaira, Tokyo, Japan
    Neuroreport 10:2575-8. 1999
    ..The APBA3 was localized by the radiation hybrid mapping to chromosome 19. Determination of the APBA3 genome structure will facilitate the linkage analysis and search for mutations in the APBA3 in patients with Alzheimer's disease...
  7. ncbi request reprint Cloning of the cDNA encoding rat presenilin-2
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, Tokyo, Japan
    Biochim Biophys Acta 1396:259-62. 1998
    ..9%), mouse (96.4%) and Xenopus (70.8%). A minor splicing variant lacking a single glutamate was detected, while the product corresponding to the exon 9 deleted splicing variant observed in human was not detected...
  8. ncbi request reprint Genome structure and chromosomal mapping of the gene for Fe65L2 interacting with Alzheimer's beta-amyloid precursor protein
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, 187 8502, Japan
    Biochem Biophys Res Commun 258:385-9. 1999
    ..Characterization of the Fe65L2 gene structure will be useful in the linkage analysis and search for mutations in the Fe65L2 gene in patients with Alzheimer's disease...
  9. ncbi request reprint Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, Tokyo, Japan
    Neurosci Lett 261:143-6. 1999
    ..We also confirmed that the carboxyl-terminal region of PID/PTB of the Fe65L2 interacted with the intracellular domain of the Alzheimer's beta-amyloid precursor protein (APP) and APP-like proteins...
  10. ncbi request reprint X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Tokyo, Kodaira, 187 8502, Japan
    Biochem Biophys Res Commun 255:663-7. 1999
    ..Unlike other members of the X11 protein family, X11L2 mRNA was expressed in various tissues...
  11. ncbi request reprint Isolation of human delta-catenin and its binding specificity with presenilin 1
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, Kodaira, Tokyo, Japan
    Neuroreport 10:563-8. 1999
    ..These results suggest that PS1 and PS2 partly differ in function. PS1 loop fragment containing the pathogenic mutation retained the binding ability. We also found another armadillo-protein, p0071, interacted with PS1...
  12. ncbi request reprint c954C-->T polymorphism in the Fe65L2 gene is associated with early-onset Alzheimer's disease
    Hiroshi Tanahashi
    Ann Neurol 52:691-3. 2002
  13. doi request reprint RNA interference silencing of DRAL affects processing of amyloid precursor protein
    Hiroshi Tanahashi
    Division of Molecular Cell Signaling, Cancer Research Institute, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa 920 0934, Japan
    Neurosci Lett 439:293-7. 2008
    ..We also found that in addition to a disintegrin and metalloprotease (ADAM)-17, DRAL binds to ADAM-10. Thus, DRAL may be involved in the processing of APP through the alpha-secretase pathway...