Hideyuki Takahashi

Summary

Affiliation: National Institute of Infectious Diseases
Country: Japan

Publications

  1. pmc Meningococcal PilV potentiates Neisseria meningitidis type IV pilus-mediated internalization into human endothelial and epithelial cells
    Hideyuki Takahashi
    Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan
    Infect Immun 80:4154-66. 2012
  2. pmc Meningococcal internalization into human endothelial and epithelial cells is triggered by the influx of extracellular L-glutamate via GltT L-glutamate ABC transporter in Neisseria meningitidis
    Hideyuki Takahashi
    Department of Bacteriology I, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
    Infect Immun 79:380-92. 2011
  3. pmc Modification of lipooligosaccharide with phosphoethanolamine by LptA in Neisseria meningitidis enhances meningococcal adhesion to human endothelial and epithelial cells
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan
    Infect Immun 76:5777-89. 2008
  4. ncbi request reprint Differential in vitro infectious abilities of two common Japan-specific sequence-type (ST) clones of disease-associated ST-2032 and carrier-associated ST-2046 Neisseria meningitidis strains in human endothelial and epithelial cell lines
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    FEMS Immunol Med Microbiol 52:36-46. 2008
  5. ncbi request reprint A broad-host-range vector of incompatibility group Q can work as a plasmid vector in Neisseria meningitidis: a new genetical tool
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
    Microbiology 148:229-36. 2002
  6. pmc A gonococcal homologue of meningococcal gamma-glutamyl transpeptidase gene is a new type of bacterial pseudogene that is transcriptionally active but phenotypically silent
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan
    BMC Microbiol 5:56. 2005
  7. ncbi request reprint Post-translational processing of Neisseria meningitidis gamma-glutamyl aminopeptidase and its association with inner membrane facing to the cytoplasmic space
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
    FEMS Microbiol Lett 234:27-35. 2004
  8. ncbi request reprint Characterization of Neisseria meningitidis isolates collected from 1974 to 2003 in Japan by multilocus sequence typing
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan
    J Med Microbiol 53:657-62. 2004
  9. ncbi request reprint Reliability of the detection of meningococcal gamma-glutamyl transpeptidase as an identification marker for Neisseria meningitidis
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan
    Microbiol Immunol 48:485-7. 2004
  10. ncbi request reprint [Neisseria gonorrhoeae]
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases
    Nihon Rinsho 61:689-95. 2003

Collaborators

  • Haruo Watanabe
  • Yuko Watanabe
  • Toshiro Kuroki
  • Kwang Kim
  • Makoto Ohnishi
  • Kenji Hirose
  • Hiroshi Tanaka
  • Kenitiro Ito
  • Hidemasa Izumiya
  • Ken Shimuta
  • David Stephens
  • Masahiro Nishihara
  • Yoshitaka Yamaguchi
  • Takeshi Urano
  • Nobuharu Fujii
  • Tomoo Shimada
  • Ikuko Hara-Nishimura
  • Kentaro Tamura
  • Atsushi Higashitani
  • Motoshi Kamada
  • Yuko Saito
  • Kentaro Fuji
  • Hirofumi Uchimiya
  • Yutaka Miyazawa
  • Seiji Yamasaki
  • Takashi L Shimada
  • Misako Yamazaki
  • Juntaro Negi
  • Takashi Nakatsuka
  • Masaharu Takahashi
  • Maki Kawai-Yamada
  • Akie Kobayashi
  • Shin Nosuke Hashida
  • Takahiro Seki
  • Masatomo Morita
  • Minobu Shimizu
  • Naoki Tanaka
  • Daisuke Kitazawa
  • Takako Takanami
  • Yohei Sasagawa
  • Kentaro Yamada
  • Hiroaki Okamoto
  • Toshinori Tanaka
  • Yasuhiro Oba
  • Kei Sato
  • Yu Hoshino
  • Osamu Matsuda
  • Koh Iba
  • Yoichiro Fukao
  • Saburo Yamamura
  • Koji Ichiyama
  • Maki Kondo
  • Takashi Nagasawa
  • Mimi Hashimoto
  • Mikio Nishimura
  • Nobuyuki Maruyama
  • Keito Nishizawa
  • Yoko Kakimoto
  • Akiko Takahashi
  • Norio Sakai
  • Yasuko Koumoto
  • Tadashi Kunieda
  • Shigeru Utsumi
  • Naoaki Saito
  • Naoko Adachi
  • Nana Abe
  • Takayuki Shimahara
  • Mitsuhiro Matsuzaki
  • Keita Suzuki
  • Makoto Harada
  • Jun Terajima
  • Hiroshi Suge
  • Atsushi Hoshino
  • Masao Tasaka
  • Makoto Matsuoka
  • Setsuko Komatsu
  • Hidemi Kitano
  • Hidehiro Fukaki
  • Shoichiro Akao
  • Shigeru Iida
  • Yasuko Hatakeda
  • Miyo Terao Morita
  • Gretchen Hagen
  • Tom Guilfoyle
  • Akiyuki Mori
  • Yuji Kohara
  • Saburo Horiuchi

Detail Information

Publications38

  1. pmc Meningococcal PilV potentiates Neisseria meningitidis type IV pilus-mediated internalization into human endothelial and epithelial cells
    Hideyuki Takahashi
    Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan
    Infect Immun 80:4154-66. 2012
    ..meningitidis internalization into human cells...
  2. pmc Meningococcal internalization into human endothelial and epithelial cells is triggered by the influx of extracellular L-glutamate via GltT L-glutamate ABC transporter in Neisseria meningitidis
    Hideyuki Takahashi
    Department of Bacteriology I, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
    Infect Immun 79:380-92. 2011
    ..meningitidis strain but not of the ΔgltT-ΔgltM mutant. These findings suggest that l-glutamate influx via the GltT-GltM L-glutamate ABC transporter serves as a cue for N. meningitidis internalization into host cells...
  3. pmc Modification of lipooligosaccharide with phosphoethanolamine by LptA in Neisseria meningitidis enhances meningococcal adhesion to human endothelial and epithelial cells
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan
    Infect Immun 76:5777-89. 2008
    ..These results indicate that modification of LOS with PEA by LptA enhances meningococcal adhesion to human endothelial and epithelial cells in unencapsulated N. meningitidis...
  4. ncbi request reprint Differential in vitro infectious abilities of two common Japan-specific sequence-type (ST) clones of disease-associated ST-2032 and carrier-associated ST-2046 Neisseria meningitidis strains in human endothelial and epithelial cell lines
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    FEMS Immunol Med Microbiol 52:36-46. 2008
    ....
  5. ncbi request reprint A broad-host-range vector of incompatibility group Q can work as a plasmid vector in Neisseria meningitidis: a new genetical tool
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
    Microbiology 148:229-36. 2002
    ..meningitidis was demonstrated to be independent of natural transformation competence. All the results indicate that pHT128 is a useful vector for N. meningitidis as a new genetical tool...
  6. pmc A gonococcal homologue of meningococcal gamma-glutamyl transpeptidase gene is a new type of bacterial pseudogene that is transcriptionally active but phenotypically silent
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan
    BMC Microbiol 5:56. 2005
    ..meningitidis is the only bacterium with GGT activity. However, nucleotide sequences highly homologous to the meningococcal ggt gene were found in the genomes of N. gonorrhoeae isolates...
  7. ncbi request reprint Post-translational processing of Neisseria meningitidis gamma-glutamyl aminopeptidase and its association with inner membrane facing to the cytoplasmic space
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
    FEMS Microbiol Lett 234:27-35. 2004
    ..This cell localization might be unique for N. meningitidis compared to other GGTs...
  8. ncbi request reprint Characterization of Neisseria meningitidis isolates collected from 1974 to 2003 in Japan by multilocus sequence typing
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan
    J Med Microbiol 53:657-62. 2004
    ..Taken together, it was speculated that meningococcal isolates in Japan comprised heterogeneous clones, which were derived both from clones identified in other countries and clones unique to Japan...
  9. ncbi request reprint Reliability of the detection of meningococcal gamma-glutamyl transpeptidase as an identification marker for Neisseria meningitidis
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan
    Microbiol Immunol 48:485-7. 2004
    ..meningitidis isolates besides NIID113. The isolation frequency (1.2%) of ggt mutants among human isolates strongly confirmed the 98.8% reliability of GGT activity as the identification marker for N. meningitidis...
  10. ncbi request reprint [Neisseria gonorrhoeae]
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases
    Nihon Rinsho 61:689-95. 2003
  11. ncbi request reprint Development of a real-time PCR assay for detection of gyrA mutations associated with reduced susceptibility to ciprofloxacin in Salmonella enterica serovar typhi and paratyphi A
    Masatomo Morita
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan
    Microbiol Immunol 50:707-11. 2006
    ..This assay allows rapid screening of S. enterica serovar Typhi and Paratyphi A with reduced susceptibility to ciprofloxacin...
  12. ncbi request reprint [Neisseria meningitidis]
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases
    Nihon Rinsho 61:683-8. 2003
  13. pmc Necessity of meningococcal gamma-glutamyl aminopeptidase for Neisseria meningitidis growth in rat cerebrospinal fluid (CSF) and CSF-like medium
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    J Bacteriol 186:244-7. 2004
    ..These results suggested that, in the environment of cysteine shortage, meningococcal GGT provided an advantage for meningococcal multiplication by supplying cysteine from environmental gamma-glutamyl-cysteinyl peptides...
  14. pmc Isolation from a healthy carrier and characterization of a Neisseria meningitidis strain that is deficient in gamma-Glutamyl aminopeptidase activity
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan
    J Clin Microbiol 40:3035-7. 2002
    ..meningitidis isolate which lacked the activity due to the insertional mutation of the ggt gene, suggesting that naturally occurring N. meningitidis isolates do not always possess GGT activity...
  15. ncbi request reprint [Plague]
    Hideyuki Takahashi
    Department of Bacteriology, National Institute of Infectious Diseases
    Nihon Rinsho 65:54-9. 2007
  16. pmc A gene essential for hydrotropism in roots
    Akie Kobayashi
    Graduate School of Life Sciences, Tohoku University, 2 1 1 Katahira, Aoba ku, Sendai 980 8577, Japan
    Proc Natl Acad Sci U S A 104:4724-9. 2007
    ..In addition, a pMIZ1::GUS fusion gene was expressed strongly in columella cells of the root cap but not in the elongation zone, suggesting that MIZ1 functions in the early phase of the hydrotropic response...
  17. ncbi request reprint [Gravity-induced asymmetry of localization of auxin-carrier proteins (CS-AUX1 and CS-PIN1) for peg formation in cucumber seedlings]
    Motoshi Kamada
    Graduate School of Life Sciences, Tohoku University
    Biol Sci Space 16:153-4. 2002
  18. ncbi request reprint Aggregate formation of mutant protein kinase C gamma found in spinocerebellar ataxia type 14 impairs ubiquitin-proteasome system and induces endoplasmic reticulum stress
    Takahiro Seki
    Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734 8551, Japan
    Eur J Neurosci 26:3126-40. 2007
    ..These results indicate that aggregate formation of mutant gamma PKC found in SCA14 impairs UPS and induces ER stress, leading to apoptotic cell death...
  19. doi request reprint Arabidopsis VPS35, a retromer component, is required for vacuolar protein sorting and involved in plant growth and leaf senescence
    Misako Yamazaki
    Graduate School of Science, Kyoto University, Kyoto 606 8502 Japan
    Plant Cell Physiol 49:142-56. 2008
    ..Our findings suggest that VPS35, mainly VPS35b, is involved in sorting proteins to PSVs in seeds, possibly by recycling VSR from PVCs to the Golgi complex, and is also involved in plant growth and senescence in vegetative organs...
  20. doi request reprint CO2 regulator SLAC1 and its homologues are essential for anion homeostasis in plant cells
    Juntaro Negi
    Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    Nature 452:483-6. 2008
    ..These results suggest that SLAC1-family proteins have an evolutionarily conserved function that is required for the maintenance of organic/inorganic anion homeostasis on the cellular level...
  21. ncbi request reprint Cloning and characterization of the UDP-glucose:anthocyanin 5-O-glucosyltransferase gene from blue-flowered gentian
    Takashi Nakatsuka
    Iwate Biotechnology Research Center, 22 174 4, Narita, Kitakami, Iwate 024 0003, Japan
    J Exp Bot 59:1241-52. 2008
    ..Heterologous expression of Gt5GT7 in tobacco plants led to additional accumulation of cyanidin 3-rutinoside-5-glucoside, confirming that Gt5GT7 has a valid enzymatic activity in planta...
  22. ncbi request reprint A novel role for oleosins in freezing tolerance of oilseeds in Arabidopsis thaliana
    Takashi L Shimada
    Department of Botany, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Plant J 55:798-809. 2008
    ..Taken together, our findings suggest that oleosins increase the viability of over-wintering oilseeds by preventing abnormal fusion of oil bodies during imbibition in the spring...
  23. ncbi request reprint Monoclonal antibodies raised against the ORF3 protein of hepatitis E virus (HEV) can capture HEV particles in culture supernatant and serum but not those in feces
    Masaharu Takahashi
    Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311 1 Yakushiji, Shimotsuke shi, Tochigi Ken 329 0498, Japan
    Arch Virol 153:1703-13. 2008
    ....
  24. pmc Identification of tet(B), encoding high-level tetracycline resistance, in Neisseria meningitidis
    Hideyuki Takahashi
    Antimicrob Agents Chemother 46:4045-6. 2002
  25. pmc Arabidopsis vacuolar sorting mutants (green fluorescent seed) can be identified efficiently by secretion of vacuole-targeted green fluorescent protein in their seeds
    Kentaro Fuji
    Department of Botany, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Plant Cell 19:597-609. 2007
    ..This method should provide valuable insights into the complex molecular mechanisms underlying vacuolar sorting of storage proteins...
  26. ncbi request reprint Arabidopsis thaliana nicotinate/nicotinamide mononucleotide adenyltransferase (AtNMNAT) is required for pollen tube growth
    Shin Nosuke Hashida
    Institute of Molecular and Cellular Biosciences IMCB, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Plant J 49:694-703. 2007
    ..Our results suggest that metabolic fulfillment via the NAD pathway is indispensable for normal pollen growth and subsequent normal seed production...
  27. ncbi request reprint Caenorhabditis elegans RBX1 is essential for meiosis, mitotic chromosomal condensation and segregation, and cytokinesis
    Yohei Sasagawa
    Graduate School of Life Sciences, Tohoku University, Sendai 980 8577, Japan
    Genes Cells 8:857-72. 2003
    ..RBX1 protein sequences are highly conserved in various species, including yeasts, Drosophila melanogaster, mice and humans. In Saccharomyces cerevisiae, RBX1 is essential for the G1/S transition...
  28. ncbi request reprint Caenorhabditis elegans Ce-rdh-1/rad-51 functions after double-strand break formation of meiotic recombination
    Takako Takanami
    Graduate School of Life Sciences, Tohoku University, 2 1 1 Katahira, Sendai 980 8577, Japan
    Chromosome Res 11:125-35. 2003
    ..These results indicate that Ce-rdh-1/rad51 functions after both endogenous and exogenous DSB formation during meiosis, but not as 'pairing centers' for meiotic synapsis...
  29. ncbi request reprint Isolation of cucumber CsARF cDNAs and expression of the corresponding mRNAs during gravity-regulated morphogenesis of cucumber seedlings
    Yuko Saito
    Graduate School of Life Sciences, Tohoku University, 2 1 1 Katahira, Aoba ku, Sendai 980 8577, Japan
    J Exp Bot 55:1315-23. 2004
    ....
  30. ncbi request reprint Differential localization of tonoplast intrinsic proteins on the membrane of protein body Type II and aleurone grain in rice seeds
    Hideyuki Takahashi
    Laboratory of Genetic Engineering, Graduate School of Agriculture, Kyoto Prefectural University, Shimogamo, Kyoto 606 8522, Japan
    Biosci Biotechnol Biochem 68:1728-36. 2004
    ..Although both the PB-II and the aleurone grain are derived from vacuoles, these results suggest that they may be derived from different types of vacuoles...
  31. pmc Effect of intramammary injection of rboGM-CSF on milk levels of chemiluminescence activity, somatic cell count, and Staphylococcus aureus count in Holstein cows with S. aureus subclinical mastitis
    Hideyuki Takahashi
    Department of Production Animal Diseases, National Institute of Animal Health, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    Can J Vet Res 68:182-7. 2004
    ..The results suggest that the rboGM-CSF has a potential as a therapeutic agent for S. aureus infection causing subclinical mastitis of dairy cows, if the cytokine is applied at the initial stage of infection...
  32. pmc Possible involvement of CS-ACS1 and ethylene in auxin-induced peg formation of cucumber seedlings
    Yuko Saito
    Graduate School of Life Sciences, Tohoku University, 2 1 1 Katahira, Aoba ku, Sendai 980 8577, Japan
    Ann Bot 95:413-22. 2005
    ..Ethylene also plays an important role in peg formation, but its relationship to auxin in this event is not understood. Here, the role ethylene plays in auxin-induced peg formation is studied...
  33. ncbi request reprint [Isolation of Neisseria meningitidis from healthy persons in Japan]
    Hiroshi Tanaka
    Ishikawa Prefectural Institute of Public Health and Environmental Science
    Kansenshogaku Zasshi 79:527-33. 2005
    ..One of the strains was found to be deficient in gamma-glutamyl aminopeptidase activity, which is an identification marker for N. meningitidis...
  34. pmc Shoot circumnutation and winding movements require gravisensing cells
    Daisuke Kitazawa
    Graduate School of Life Sciences, Tohoku University, 2 1 1 Katahira, Aoba ku, Sendai 980 8577, Japan
    Proc Natl Acad Sci U S A 102:18742-7. 2005
    ..Thus, our data show that gravisensing endodermal cells are indispensable for shoot circumnutation and the winding response and that PnSCR is responsible for the abnormal phenotypes of weeping...
  35. ncbi request reprint Differential accumulation of the mRNA of the auxin-repressed gene CsGRP1 and the auxin-induced peg formation during gravimorphogenesis of cucumber seedlings
    Minobu Shimizu
    Graduate School of Life Sciences, Tohoku University, 2 1 1 Katahira, Aoba ku, Sendai 980 8577, Japan
    Planta 225:13-22. 2006
    ..These results suggest that the transition zone responds to gravistimulation in a specific manner by an asymmetric expression of CsGRP1 gene during regulation of peg formation...
  36. ncbi request reprint Gravity-induced modification of auxin transport and distribution for peg formation in cucumber seedlings: possible roles for CS-AUX1 and CS-PIN1
    Motoshi Kamada
    Graduate School of Life Sciences, Tohoku University, Katahira, Aoba ku, 980 8577 Sendai, Japan
    Planta 218:15-26. 2003
    ..It is therefore possible that a balance in the activities of auxin influx and efflux carriers controls intracellular auxin concentration at the transition zone, which results in lateral placement of a peg in cucumber seedlings...
  37. pmc Arabidopsis KAM2/GRV2 is required for proper endosome formation and functions in vacuolar sorting and determination of the embryo growth axis
    Kentaro Tamura
    Department of Botany, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Plant Cell 19:320-32. 2007
    ..Our findings suggest that KAM2/GRV2 is required for proper formation of the endosomes involving protein trafficking to the vacuoles and determination of growth axis of the embryo...
  38. ncbi request reprint Proteome approach to characterize the methylmalonate-semialdehyde dehydrogenase that is regulated by gibberellin
    Naoki Tanaka
    Department of Molecular Genetics, National Institute of Agrobiological Sciences, Tsukuba 305 8602, Japan
    J Proteome Res 4:1575-82. 2005
    ..These results suggest that one of the regulations by GA signal transduction including SLR1 is the expression of MMSDH, and that MMSDH may play a role in root development and leaf sheath elongation in rice...